The antibacterial and drug-loaded bilayer poly(ε-caprolactone) fibrous membrane with a shish-kebab structure

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2024-12-09 DOI:10.1007/s11706-024-0703-y

Chang Mao, Shan Liang, Yinchun Hu, Yan Wei, Di Huang

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引用次数: 0

Abstract

Electrospinning has been widely used in the field of biomedical materials characterized with high porosity and good breathability as well as similarity to the natural extracellular matrix. This study employs the microsol-electrospinning technology combined with the self-induced crystallization method to fabricate the functionalized bilayer poly(ε-caprolactone) (PCL) fibrous membrane with a shish-kebab (SK) structure. The outer layer consists of the antibacterial SK-structured fibrous membrane showing favorable mechanical properties and notable inhibitory effects on the growth of E. coli and S. aureus, while salvianic acid A sodium (SAS) is encapsulated in the inner core–shell and SK-structured PCL fibrous membrane, achieving the controlled and sustained release of SAS. Moreover, good biocompatibility and enhanced cell adhesion of this membrane are also revealed. This antibacterial and drug-loaded bilayer PCL fibrous membrane with a SK structure demonstrates superior mechanical characteristics, exceptional antibacterial properties, and notable biocompatibility, suggesting its favorable outlook for future development in the area of tissue engineering.

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具有羊肉串结构的抗菌载药双层聚ε-己内酯纤维膜

静电纺丝具有气孔率高、透气性好、与天然细胞外基质相似等特点，已广泛应用于生物医用材料领域。本研究采用微溶胶-静电纺丝技术结合自诱导结晶法制备了羊肉串（SK）结构的功能化双层聚ε-己内酯（PCL）纤维膜。外层为抗菌的sk结构纤维膜，具有良好的力学性能，对大肠杆菌和金黄色葡萄球菌的生长有明显的抑制作用，而内层的核壳和sk结构的PCL纤维膜包裹着丹丹酸A钠（SAS），实现了SAS的控释和缓释。此外，该膜具有良好的生物相容性和增强的细胞粘附性。这种具有SK结构的抗菌载药双层PCL纤维膜具有优异的力学特性、抗菌性能和显著的生物相容性，在组织工程领域具有良好的发展前景。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.