JMIR Medical Informatics最新文献

筛选
英文 中文
Information Source Characteristics of Personal Data Leakage During the COVID-19 Pandemic in China: Observational Study. 中国 COVID-19 大流行期间个人数据泄露的信息源特征:观察研究。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-12-10 DOI: 10.2196/51219
Zhong Wang, Fangru Hu, Jie Su, Yuyao Lin
{"title":"Information Source Characteristics of Personal Data Leakage During the COVID-19 Pandemic in China: Observational Study.","authors":"Zhong Wang, Fangru Hu, Jie Su, Yuyao Lin","doi":"10.2196/51219","DOIUrl":"10.2196/51219","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, in the period of preventing and controlling the spread of the virus, a large amount of personal data was collected in China, and privacy leakage incidents occurred.</p><p><strong>Objective: </strong>We aimed to examine the information source characteristics of personal data leakage during the COVID-19 pandemic in China.</p><p><strong>Methods: </strong>We extracted information source characteristics of 40 personal data leakage cases using open coding and analyzed the data with 1D and 2D matrices.</p><p><strong>Results: </strong>In terms of organizational characteristics, data leakage cases mainly occurred in government agencies below the prefecture level, while few occurred in the medical system or in high-level government organizations. The majority of leakers were regular employees or junior staff members rather than temporary workers or senior managers. Family WeChat groups were the primary route for disclosure; the forwarding of documents was the main method of divulgence, while taking screenshots and pictures made up a comparatively smaller portion.</p><p><strong>Conclusions: </strong>We propose the following suggestions: restricting the authority of nonmedical institutions and low-level government agencies to collect data, strengthening training for low-level employees on privacy protection, and restricting the flow of data on social media through technical measures.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e51219"},"PeriodicalIF":3.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development, Implementation, and Evaluation Methods for Dashboards in Health Care: Scoping Review. 医疗保健仪表板的开发、实施和评估方法:范围审查。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-12-10 DOI: 10.2196/59828
Danielle Helminski, Jeremy B Sussman, Paul N Pfeiffer, Alex N Kokaly, Allison Ranusch, Anjana Deep Renji, Laura J Damschroder, Zach Landis-Lewis, Jacob E Kurlander
{"title":"Development, Implementation, and Evaluation Methods for Dashboards in Health Care: Scoping Review.","authors":"Danielle Helminski, Jeremy B Sussman, Paul N Pfeiffer, Alex N Kokaly, Allison Ranusch, Anjana Deep Renji, Laura J Damschroder, Zach Landis-Lewis, Jacob E Kurlander","doi":"10.2196/59828","DOIUrl":"10.2196/59828","url":null,"abstract":"<p><strong>Background: </strong>Dashboards have become ubiquitous in health care settings, but to achieve their goals, they must be developed, implemented, and evaluated using methods that help ensure they meet the needs of end users and are suited to the barriers and facilitators of the local context.</p><p><strong>Objective: </strong>This scoping review aimed to explore published literature on health care dashboards to characterize the methods used to identify factors affecting uptake, strategies used to increase dashboard uptake, and evaluation methods, as well as dashboard characteristics and context.</p><p><strong>Methods: </strong>MEDLINE, Embase, Web of Science, and the Cochrane Library were searched from inception through July 2020. Studies were included if they described the development or evaluation of a health care dashboard with publication from 2018-2020. Clinical setting, purpose (categorized as clinical, administrative, or both), end user, design characteristics, methods used to identify factors affecting uptake, strategies to increase uptake, and evaluation methods were extracted.</p><p><strong>Results: </strong>From 116 publications, we extracted data for 118 dashboards. Inpatient (45/118, 38.1%) and outpatient (42/118, 35.6%) settings were most common. Most dashboards had ≥2 stated purposes (84/118, 71.2%); of these, 54 of 118 (45.8%) were administrative, 43 of 118 (36.4%) were clinical, and 20 of 118 (16.9%) had both purposes. Most dashboards included frontline clinical staff as end users (97/118, 82.2%). To identify factors affecting dashboard uptake, half involved end users in the design process (59/118, 50%); fewer described formative usability testing (26/118, 22%) or use of any theory or framework to guide development, implementation, or evaluation (24/118, 20.3%). The most common strategies used to increase uptake included education (60/118, 50.8%); audit and feedback (59/118, 50%); and advisory boards (54/118, 45.8%). Evaluations of dashboards (84/118, 71.2%) were mostly quantitative (60/118, 50.8%), with fewer using only qualitative methods (6/118, 5.1%) or a combination of quantitative and qualitative methods (18/118, 15.2%).</p><p><strong>Conclusions: </strong>Most dashboards forego steps during development to ensure they suit the needs of end users and the clinical context; qualitative evaluation-which can provide insight into ways to improve dashboard effectiveness-is uncommon. Education and audit and feedback are frequently used to increase uptake. These findings illustrate the need for promulgation of best practices in dashboard development and will be useful to dashboard planners.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e59828"},"PeriodicalIF":3.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Progressive Web Applications to Leverage Medical Imaging for Visualization of Digital Imaging and Communications in Medicine and Multiplanar Reconstruction: Software Development and Validation Study. 推进渐进式Web应用程序以利用医学成像实现医学和多平面重建中的数字成像和通信的可视化:软件开发和验证研究。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-12-09 DOI: 10.2196/63834
Mohammed A AboArab, Vassiliki T Potsika, Alexis Theodorou, Sylvia Vagena, Miltiadis Gravanis, Fragiska Sigala, Dimitrios I Fotiadis
{"title":"Advancing Progressive Web Applications to Leverage Medical Imaging for Visualization of Digital Imaging and Communications in Medicine and Multiplanar Reconstruction: Software Development and Validation Study.","authors":"Mohammed A AboArab, Vassiliki T Potsika, Alexis Theodorou, Sylvia Vagena, Miltiadis Gravanis, Fragiska Sigala, Dimitrios I Fotiadis","doi":"10.2196/63834","DOIUrl":"10.2196/63834","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In medical imaging, 3D visualization is vital for displaying volumetric organs, enhancing diagnosis and analysis. Multiplanar reconstruction (MPR) improves visual and diagnostic capabilities by transforming 2D images from computed tomography (CT) and magnetic resonance imaging into 3D representations. Web-based Digital Imaging and Communications in Medicine (DICOM) viewers integrated into picture archiving and communication systems facilitate access to pictures and interaction with remote data. However, the adoption of progressive web applications (PWAs) for web-based DICOM and MPR visualization remains limited. This paper addresses this gap by leveraging PWAs for their offline access and enhanced performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to evaluate the integration of DICOM and MPR visualization into the web using PWAs, addressing challenges related to cross-platform compatibility, integration capabilities, and high-resolution image reconstruction for medical image visualization.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Our paper introduces a PWA that uses a modular design for enhancing DICOM and MPR visualization in web-based medical imaging. By integrating React.js and Cornerstone.js, the application offers seamless DICOM image processing, ensures cross-browser compatibility, and delivers a responsive user experience across multiple devices. It uses advanced interpolation techniques to make volume reconstructions more accurate. This makes MPR analysis and visualization better in a web environment, thus promising a substantial advance in medical imaging analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In our approach, the performance of DICOM- and MPR-based PWAs for medical image visualization and reconstruction was evaluated through comprehensive experiments. The application excelled in terms of loading time and volume reconstruction, particularly in Google Chrome, whereas Firefox showed superior performance in viewing slices. This study uses a dataset comprising 22 CT scans of peripheral artery patients to demonstrate the application's robust performance, with Google Chrome outperforming other browsers in both the local area network and wide area network settings. In addition, the application's accuracy in MPR reconstructions was validated with an error margin of &lt;0.05 mm and outperformed the state-of-the-art methods by 84% to 98% in loading and volume rendering time.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This paper highlights advancements in DICOM and MPR visualization using PWAs, addressing the gaps in web-based medical imaging. By exploiting PWA features such as offline access and improved performance, we have significantly advanced medical imaging technology, focusing on cross-platform compatibility, integration efficiency, and speed. Our application outperforms existing platforms for handling complex MPR analyses and accurate analysis of medical imaging as validated through peripheral artery CT imaging.","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e63834"},"PeriodicalIF":3.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EyeMatics: An Ophthalmology Use Case Within the German Medical Informatics Initiative. eyeematics:德国医学信息学倡议中的眼科用例。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-12-05 DOI: 10.2196/60851
Julian Varghese, Alexander Schuster, Broder Poschkamp, Kemal Yildirim, Johannes Oehm, Philipp Berens, Sarah Müller, Julius Gervelmeyer, Lisa Koch, Katja Hoffmann, Martin Sedlmayr, Vinodh Kakkassery, Oliver Kohlbacher, David Merle, Karl Ulrich Bartz-Schmidt, Marius Ueffing, Dana Stahl, Torsten Leddig, Martin Bialke, Christopher Hampf, Wolfgang Hoffmann, Sebastian Berthe, Dagmar Waltemath, Peter Walter, Myriam Lipprandt, Rainer Röhrig, Jens Julian Storp, Julian Alexander Zimmermann, Lea Holtrup, Tobias Brix, Andreas Stahl, Nicole Eter
{"title":"EyeMatics: An Ophthalmology Use Case Within the German Medical Informatics Initiative.","authors":"Julian Varghese, Alexander Schuster, Broder Poschkamp, Kemal Yildirim, Johannes Oehm, Philipp Berens, Sarah Müller, Julius Gervelmeyer, Lisa Koch, Katja Hoffmann, Martin Sedlmayr, Vinodh Kakkassery, Oliver Kohlbacher, David Merle, Karl Ulrich Bartz-Schmidt, Marius Ueffing, Dana Stahl, Torsten Leddig, Martin Bialke, Christopher Hampf, Wolfgang Hoffmann, Sebastian Berthe, Dagmar Waltemath, Peter Walter, Myriam Lipprandt, Rainer Röhrig, Jens Julian Storp, Julian Alexander Zimmermann, Lea Holtrup, Tobias Brix, Andreas Stahl, Nicole Eter","doi":"10.2196/60851","DOIUrl":"10.2196/60851","url":null,"abstract":"<p><strong>Unlabelled: </strong>The EyeMatics project, embedded as a clinical use case in Germany's Medical Informatics Initiative, is a large digital health initiative in ophthalmology. The objective is to improve the understanding of the treatment effects of intravitreal injections, the most frequent procedure to treat eye diseases. To achieve this, valuable patient data will be meaningfully integrated and visualized from different IT systems and hospital sites. EyeMatics emphasizes a governance framework that actively involves patient representatives, strictly implements interoperability standards, and employs artificial intelligence methods to extract biomarkers from tabular and clinical data as well as raw retinal scans. In this perspective paper, we delineate the strategies for user-centered implementation and health care-based evaluation in a multisite observational technology study.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e60851"},"PeriodicalIF":3.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital Solutions for Health Services and Systems Management: Narrative Review of Certified Software Features in the Brazilian Market. 卫生服务和系统管理的数字解决方案:巴西市场认证软件功能的叙述回顾。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-29 DOI: 10.2196/65281
Ericles Andrei Bellei, Pedro Rafael Domenighi, Carla Maria Dal Sasso Freitas, Ana Carolina Bertoletti De Marchi
{"title":"Digital Solutions for Health Services and Systems Management: Narrative Review of Certified Software Features in the Brazilian Market.","authors":"Ericles Andrei Bellei, Pedro Rafael Domenighi, Carla Maria Dal Sasso Freitas, Ana Carolina Bertoletti De Marchi","doi":"10.2196/65281","DOIUrl":"10.2196/65281","url":null,"abstract":"<p><strong>Unlabelled: </strong>The paper reviews digital solutions for health services management in Brazil, focusing on certified software features. It reveals the integration of various functionalities in operational, financial, and clinical needs simultaneously, which are critical for enhancing operational efficiency and patient care. This study highlights the integration of critical features like interoperability, compliance management, and data-driven decision support, although advancing innovation and integration remains essential for broader impact.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e65281"},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: The University Medicine Greifswald's Trusted Third Party Dispatcher: State-of-the-Art Perspective Into Comprehensive Architectures and Complex Research Workflows. 作者回复:大学医学Greifswald的可信第三方调度员:综合架构和复杂研究工作流程的最新视角。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-29 DOI: 10.2196/67429
Eric Wündisch, Peter Hufnagl, Peter Brunecker, Sophie Meier Zu Ummeln, Sarah Träger, Fabian Prasser, Joachim Weber
{"title":"Authors' Reply: The University Medicine Greifswald's Trusted Third Party Dispatcher: State-of-the-Art Perspective Into Comprehensive Architectures and Complex Research Workflows.","authors":"Eric Wündisch, Peter Hufnagl, Peter Brunecker, Sophie Meier Zu Ummeln, Sarah Träger, Fabian Prasser, Joachim Weber","doi":"10.2196/67429","DOIUrl":"10.2196/67429","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e67429"},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The University Medicine Greifswald's Trusted Third Party Dispatcher: State-of-the-Art Perspective Into Comprehensive Architectures and Complex Research Workflows. 大学医学Greifswald的可信第三方调度员:最先进的视角进入综合架构和复杂的研究工作流程。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-29 DOI: 10.2196/65784
Martin Bialke, Dana Stahl, Torsten Leddig, Wolfgang Hoffmann
{"title":"The University Medicine Greifswald's Trusted Third Party Dispatcher: State-of-the-Art Perspective Into Comprehensive Architectures and Complex Research Workflows.","authors":"Martin Bialke, Dana Stahl, Torsten Leddig, Wolfgang Hoffmann","doi":"10.2196/65784","DOIUrl":"10.2196/65784","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e65784"},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analyzing Patient Experience on Weibo: Machine Learning Approach to Topic Modeling and Sentiment Analysis. 微博患者体验分析:主题建模和情感分析的机器学习方法。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-29 DOI: 10.2196/59249
Xiao Chen, Zhiyun Shen, Tingyu Guan, Yuchen Tao, Yichen Kang, Yuxia Zhang
{"title":"Analyzing Patient Experience on Weibo: Machine Learning Approach to Topic Modeling and Sentiment Analysis.","authors":"Xiao Chen, Zhiyun Shen, Tingyu Guan, Yuchen Tao, Yichen Kang, Yuxia Zhang","doi":"10.2196/59249","DOIUrl":"10.2196/59249","url":null,"abstract":"<p><strong>Background: </strong>Social media platforms allow individuals to openly gather, communicate, and share information about their interactions with health care services, becoming an essential supplemental means of understanding patient experience.</p><p><strong>Objective: </strong>We aimed to identify common discussion topics related to health care experience from the public's perspective and to determine areas of concern from patients' perspectives that health care providers should act on.</p><p><strong>Methods: </strong>This study conducted a spatiotemporal analysis of the volume, sentiment, and topic of patient experience-related posts on the Weibo platform developed by Sina Corporation. We applied a supervised machine learning approach including human annotation and machine learning-based models for topic modeling and sentiment analysis of the public discourse. A multiclassifier voting method based on logistic regression, multinomial naïve Bayes, and random forest was used.</p><p><strong>Results: </strong>A total of 4008 posts were manually classified into patient experience topics. A patient experience theme framework was developed. The accuracy, precision, recall, and F-measure of the method integrating logistic regression, multinomial naïve Bayes, and random forest for patient experience themes were 0.93, 0.95, 0.80, 0.77, and 0.84, respectively, indicating a satisfactory prediction. The sentiment analysis revealed that negative sentiment posts constituted the highest proportion (3319/4008, 82.81%). Twenty patient experience themes were discussed on the social media platform. The majority of the posts described the interpersonal aspects of care (2947/4008, 73.53%); the five most frequently discussed topics were \"health care professionals' attitude,\" \"access to care,\" \"communication, information, and education,\" \"technical competence,\" and \"efficacy of treatment.\"</p><p><strong>Conclusions: </strong>Hospital administrators and clinicians should consider the value of social media and pay attention to what patients and their family members are communicating on social media. To increase the utility of these data, a machine learning algorithm can be used for topic modeling. The results of this study highlighted the interpersonal and functional aspects of care, especially the interpersonal aspects, which are often the \"moment of truth\" during a service encounter in which patients make a critical evaluation of hospital services.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e59249"},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Implementation of a Dashboard for Drug Interactions Mediated by Cytochromes Using a Health Care Data Warehouse in a University Hospital Center: Development Study. 利用大学医院中心的卫生保健数据仓库设计和实现细胞色素介导的药物相互作用仪表板:发展研究。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-28 DOI: 10.2196/57705
Laura Gosselin, Alexandre Maes, Kevin Eyer, Badisse Dahamna, Flavien Disson, Stefan Darmoni, Julien Wils, Julien Grosjean
{"title":"Design and Implementation of a Dashboard for Drug Interactions Mediated by Cytochromes Using a Health Care Data Warehouse in a University Hospital Center: Development Study.","authors":"Laura Gosselin, Alexandre Maes, Kevin Eyer, Badisse Dahamna, Flavien Disson, Stefan Darmoni, Julien Wils, Julien Grosjean","doi":"10.2196/57705","DOIUrl":"10.2196/57705","url":null,"abstract":"<p><strong>Background: </strong>The enzymatic system of cytochrome P450 (CYP450) is a group of enzymes involved in the metabolism of drugs present in the liver. Literature records instances of underdosing of drugs due to the concurrent administration of another drug that strongly induces the same cytochrome for which the first drug is a substrate and overdosing due to strong inhibition. IT solutions have been proposed to raise awareness among prescribers to mitigate these interactions.</p><p><strong>Objective: </strong>This study aimed to develop a drug interaction dashboard for Cytochrome-mediated drug interactions (DIDC) using a health care data warehouse to display results that are easily readable and interpretable by clinical experts.</p><p><strong>Methods: </strong>The initial step involved defining requirements with expert pharmacologists. An existing model of interactions involving the (CYP450) was used. A program for the automatic detection of cytochrome-mediated drug interactions (DI) was developed. Finally, the development and visualization of the DIDC were carried out by an IT engineer. An evaluation of the tool was carried out.</p><p><strong>Results: </strong>The development of the DIDC was successfully completed. It automatically compiled cytochrome-mediated DIs in a comprehensive table and provided a dedicated dashboard for each potential DI. The most frequent interaction involved paracetamol and carbamazepine with CYP450 3A4 (n=50 patients). The prescription of tacrolimus with CYP3A5 genotyping pertained to 675 patients. Two experts qualitatively evaluated the tool, resulting in overall satisfaction scores of 6 and 5 out of 7, respectively.</p><p><strong>Conclusions: </strong>At our hospital, measurements of molecules that could have altered concentrations due to cytochrome-mediated DIs are not systematic. These DIs can lead to serious clinical consequences. The purpose of this DIDC is to provide an overall view and raise awareness among prescribers about the importance of measuring concentrations of specific drugs and metabolites. Ultimately, the tool could lead to an individualized approach and become a prescription support tool if integrated into prescription assistance software.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e57705"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Machine Learning to Predict the Duration of Atrial Fibrillation: Model Development and Validation. 使用机器学习预测心房颤动的持续时间:模型开发与验证。
IF 3.1 3区 医学
JMIR Medical Informatics Pub Date : 2024-11-22 DOI: 10.2196/63795
Satoshi Shimoo, Keitaro Senoo, Taku Okawa, Kohei Kawai, Masahiro Makino, Jun Munakata, Nobunari Tomura, Hibiki Iwakoshi, Tetsuro Nishimura, Hirokazu Shiraishi, Keiji Inoue, Satoaki Matoba
{"title":"Using Machine Learning to Predict the Duration of Atrial Fibrillation: Model Development and Validation.","authors":"Satoshi Shimoo, Keitaro Senoo, Taku Okawa, Kohei Kawai, Masahiro Makino, Jun Munakata, Nobunari Tomura, Hibiki Iwakoshi, Tetsuro Nishimura, Hirokazu Shiraishi, Keiji Inoue, Satoaki Matoba","doi":"10.2196/63795","DOIUrl":"10.2196/63795","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is a progressive disease, and its clinical type is classified according to the AF duration: paroxysmal AF, persistent AF (PeAF; AF duration of less than 1 year), and long-standing persistent AF (AF duration of more than 1 year). When considering the indication for catheter ablation, having a long AF duration is considered a risk factor for recurrence, and therefore, the duration of AF is an important factor in determining the treatment strategy for PeAF.</p><p><strong>Objective: </strong>This study aims to improve the accuracy of the cardiologists' diagnosis of the AF duration, and the steps to achieve this goal are to develop a predictive model of the AF duration and validate the support performance of the prediction model.</p><p><strong>Methods: </strong>The study included 272 patients with PeAF (aged 20-90 years), with data obtained between January 1, 2015, and December 31, 2023. Of those, 189 (69.5%) were included in the study, excluding 83 (30.5%) who met the exclusion criteria. Of the 189 patients included, 145 (76.7%) were used as training data to build the machine learning (ML) model and 44 (23.3%) were used as test data for predictive ability of the ML model. Using a questionnaire, 10 cardiologists (group A) evaluated whether the test data (44 patients) included AF of more than a 1-year duration (phase 1). Next, the same questionnaire was performed again after providing the ML model's answer (phase 2). Subsequently, another 10 cardiologists (group B) were shown the test results of group A, were made aware of the limitations of their own diagnostic abilities, and were then administered the same 2-stage test as group A.</p><p><strong>Results: </strong>The prediction results with the ML model using the test data provided 81.8% accuracy (72% sensitivity and 89% specificity). The mean percentage of correct answers in group A was 63.9% (SD 9.6%) for phase 1 and improved to 71.6% (SD 9.3%) for phase 2 (P=.01). The mean percentage of correct answers in group B was 59.8% (SD 5.3%) for phase 1 and improved to 68.2% (SD 5.9%) for phase 2 (P=.007). The mean percentage of answers that differed from the ML model's prediction for phase 2 (percentage of answers where cardiologists did not trust the ML model and believed their own determination) was 17.3% (SD 10.3%) in group A and 20.9% (SD 5%) in group B and was not significantly different (P=.85).</p><p><strong>Conclusions: </strong>ML models predicting AF duration improved the diagnostic ability of cardiologists. However, cardiologists did not entirely rely on the ML model's prediction, even if they were aware of their diagnostic capability limitations.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"12 ","pages":"e63795"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信