Cancer Epidemiology最新文献

{"title":"Favorable trends in lung cancer incidence with unfavorable survival prognosis: A spatiotemporal analysis by histology in Córdoba, Argentina","authors":"Marcela Guadalupe Canale ,&nbsp;Fabian Leonardo Muñoz ,&nbsp;Sonia Edith Muñoz ,&nbsp;Maria del Pilar Diaz","doi":"10.1016/j.canep.2025.102796","DOIUrl":"10.1016/j.canep.2025.102796","url":null,"abstract":"<div><div>Lung cancer (LC) represents the leading cause of cancer-related death and the third in incidence in Argentina. Survival rates are low. Objective: To analyze the spatial distribution of LC incidence in Córdoba-Argentina (2004‐2014), explore trends in histological types, and estimate the probability of survival.</div></div><div><h3>Methods</h3><div>A longitudinal ecological study was conducted using data from the Provincial Cancer Registry. Age-specific and standardized incidence rates for LC (ICD-10: C33–34) were calculated, truncated (35–84 years), and stratified by sex, year (2004–2014), and histology (small cell carcinoma and non-small cell: adenocarcinoma, squamous cells, large cells, and other carcinomas). Temporal analysis employed Joinpoint regression models, estimating annual percentage changes (APC). Median times estimated survival curves and semiparametric Cox regression models were employed for survival. Statistical significance: log-rank tests and proportional hazards tests. Software: Joinpoint-Regression-Program and Stata17.</div></div><div><h3>Results</h3><div>From 2004–2014, 8246 LC cases were diagnosed in individuals aged 35–84. The highest incidence occurred in males aged 75–79 and females aged 80–84. The Age-standardized incidence rates for males and females were 57.9 and 23.6 cases per 100,000 person-years, respectively. In both sexes, the temporal incidence trend was decreasing (APC −3.21 %; p = 0.001), more pronounced in males (APC −3.99 %, p = 0.011), with negative APCs in all histological subtypes. The probability of survival decreased to 32 % (95 %CI: 31 %-34 %) within just 12 months (38 % in females, 30 % in males). The risk of death increased proportionally with age (males HR: 1.007, (95 %CI: 1.004–1.01, p = 0.000); females HR: 1.005, (95 %CI: 1.00–1.01, p = 0.031)) and across all histological types, with lower proportional risks in females and disparities based on histology: in males, the highest risk was in large cells (p = 0.008) and SMCC, while in females, it was SCLC (p = 0.055).</div></div><div><h3>Conclusions</h3><div>Despite estimating a favorable trend in LC incidence since 2004, the survival prognosis remains unfavorable one-year post-diagnosis, dependent on sex, age, and histological type.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102796"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer characteristics in low- and middle-income countries: An umbrella review","authors":"Lisbeth Tolentino-Rodriguez ,&nbsp;Mohamad Chkeir ,&nbsp;Vanina Pofagi ,&nbsp;Irénée Ahindu ,&nbsp;Jean Toniolo ,&nbsp;Andrea Erazo ,&nbsp;Pierre-Marie Preux ,&nbsp;Véronique Blanquet ,&nbsp;Marion Vergonjeanne ,&nbsp;Alexis Parenté","doi":"10.1016/j.canep.2025.102797","DOIUrl":"10.1016/j.canep.2025.102797","url":null,"abstract":"<div><div>Breast cancer presents significant challenges in low- and middle-income countries (LMICs) due to disparities in healthcare access and outcomes. This umbrella review synthesizes data on breast cancer characteristics—age at diagnosis, staging, and molecular subtypes—to guide targeted healthcare strategies in LMICs. Our umbrella review was conducted following PRISMA 2020 and JBI guidelines. Systematic reviews from 2009 to 2024 were sourced from PubMed, Google Scholar, and Cochrane. Reviews were assessed with AMSTAR 2, and only those rated moderate or higher were included. Data synthesis and meta-analyses were performed using R. From 1165 records, 35 systematic reviews met initial criteria; nine were included in the final synthesis, representing 305 primary studies (195 relevant to LMICs). Of those, 50 % were hospital-based and 22 % population-based, limiting the generalizability of the data and the importance of promoting more population-based studies. The overall quality of systematic reviews was variable, with only a few meeting high standards. Geographic analysis revealed a significant underrepresentation of high-quality reviews in sub-Saharan Africa and Latin America. Age at diagnosis varied: sub-Saharan Africa (45–52 years), Middle East (36–56 years), and Latin America (∼49–53 years). Advanced-stage diagnoses (stages III and IV) were common, worsening prognostic outcomes. Molecular subtype analysis indicated a predominance of luminal A but highlighted treatment challenges due to limited targeted therapy access. The results emphasize a pressing need to enhance the availability and quality of primary data, including both hospital-based and population-based studies, particularly in underrepresented regions like sub-Saharan Africa and Latin America. Addressing these gaps with rigorous, locally focused studies is essential for improving breast cancer prevention, diagnosis, and treatment. Enhancing methodological standards and expanding research in these areas will be crucial to bridging global breast cancer outcomes disparities.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102797"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and an age-period-cohort analysis of testicular cancer incidence and mortality in China from 1990 to 2021","authors":"Lei Ren ,&nbsp;Jinping Xie ,&nbsp;Jiahao Wang ,&nbsp;Gaonie Chen ,&nbsp;Rong Shao","doi":"10.1016/j.canep.2024.102736","DOIUrl":"10.1016/j.canep.2024.102736","url":null,"abstract":"<div><h3>Background</h3><div>The testicular cancer incidence rate in China has been rising since 1990, which has brought a huge burden to China, but its influencing factors are still under discussion. This study aims to investigate the trends of testicular cancer incidence and mortality in China from 1990 to 2021.</div></div><div><h3>Methods</h3><div>The trends were estimated by the Estimated Annual Percentage Change model and Joinpoint regression analysis model using the data from GBD 2021, and the influence of age, period, and birth cohort on testicular cancer within the analysis model of age-period-cohort.</div></div><div><h3>Results</h3><div>The age-standardized incidence rate (per 100,000) became 2.24 (95 % UI 2.16–2.35) in 2021 from 1.50(95 % UI 1.45–1.55) in 1990; the age-standardized mortality rate (per 100,000) became 0.29 (95 % UI 0.27–0.30) in 2021 from 0.33(95 % UI 0.32–0.35) in 1990. The incidence and mortality in different age groups were different under the influence of various periods. The risk of incidence and mortality of testicular cancer peaks for the first time in young adulthood (around age 30–34) and starts to increase again from the age of 55–59; the incidence risk has shown a continuous upward trend, while the mortality risk has exhibited a fluctuating downward trend in period effects; the mortality risk has shown a decreasing trend, but the incidence risk among recent birth cohorts has been increasing in birth cohort effects.</div></div><div><h3>Conclusion</h3><div>It is crucial to focus on cancer screening for both adolescents and older adults for testicular cancer, and pay more appropriate interventions to individuals born in recent years.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102736"},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there inequalities in ovarian cancer diagnosis and treatment in England? A population-based study","authors":"Benjamin A. Pickwell-Smith ,&nbsp;Lewis W. Paton ,&nbsp;Ireneous Soyiri ,&nbsp;Michael Lind ,&nbsp;Una Macleod","doi":"10.1016/j.canep.2025.102778","DOIUrl":"10.1016/j.canep.2025.102778","url":null,"abstract":"<div><h3>Introduction</h3><div>Ovarian cancer ranks as the sixth leading cause of cancer-related mortality among women. Notably, there is a deprivation gradient in survival rates, with individuals from more affluent socioeconomic groups more likely to be alive at five years following diagnosis. This study examines disparities in treatment received and the timeliness of diagnosis and treatment across different socioeconomic groups in England, a country with universal healthcare.</div></div><div><h3>Methods</h3><div>The Cancer Registry identified a retrospective cohort of patients diagnosed with ovarian cancer in England between 2016 and 2017. Registry data were linked to Hospital Episode Statistics, Cancer Pathway, Systematic Anti-Cancer Dataset, and Diagnostic Imaging Datasets. The odds of surgery and chemotherapy were evaluated using logistic regression. The secondary care diagnostic interval methodology was used to calculate the starting point for the measurement of time to diagnosis and treatment and was analysed using quantile regression. All analyses were conducted using Stata v17. The study was registered on ClinicalTrials.gov (NCT05185388).</div></div><div><h3>Results</h3><div>A total of 9572 patients were included in the analysis. Area deprivation was a significant predictor of receipt of surgery and chemotherapy. The odds of having surgery and chemotherapy were 0.68 (95 % CI 0.57–0.82) and 0.68 (95 % CI 0.56–0.81), respectively, for patients from the most deprived quintile, adjusting for other factors. The interval measured from the beginning of the diagnostic pathway to treatment was significantly longer for patients from the most, compared with the least deprived areas after adjusting for important factors (median difference 4.50 days [95 % CI 2.72–6.28]).</div></div><div><h3>Conclusion</h3><div>In this large cohort of patients with ovarian cancer in England, we demonstrated that patients from more deprived areas are less likely to receive surgery or chemotherapy and wait longer to commence treatment. Further research is needed to understand why and what evidence-based actions can reduce these inequalities in treatment and timeliness.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102778"},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notification of locoregional breast cancer recurrence based on pathology reports: A nationwide validation study with the Netherlands Cancer Registry","authors":"Marissa C. van Maaren ,&nbsp;Quirinus J.M. Voorham ,&nbsp;Eveline M. Wijnen ,&nbsp;Linda de Munck ,&nbsp;Jelle Wesseling ,&nbsp;Otto Visser ,&nbsp;Sabine Siesling","doi":"10.1016/j.canep.2025.102780","DOIUrl":"10.1016/j.canep.2025.102780","url":null,"abstract":"<div><h3>Background</h3><div>Usually, data on locoregional recurrent breast cancer (LRR) are collected by reviewing all patient files of a specific cohort, despite only few patients actually have a LRR. We describe and validate a new procedure in which notifications of LRRs are obtained via pathology reports, which could improve efficiency.</div></div><div><h3>Methods</h3><div>Patients diagnosed with nonmetastatic invasive breast cancer between 2012 and 2016 were identified from the Netherlands Cancer Registry (NCR) and linked to the Dutch Nationwide Pathology Databank (Palga). LRRs were identified using a complex algorithm based on codes and text in pathology reports, whereafter only files from patients with a notification – i.e. patients who were suspected of having had a LRR – were consulted for confirmation and additional information.</div><div>To validate this procedure, patients diagnosed between January-March 2012 – of whom data on LRRs were previously collected manually by registrars from the Netherlands Cancer Registry – were used as the gold standard. Subsequently, patients with LRRs not notified by the new method were identified and original pathology reports and clinical reports were evaluated to find reasons for the lack of notification.</div></div><div><h3>Results</h3><div>In total, 88,257 patients were linked to Palga, and 5069 patients were labelled with a notification. In patients diagnosed between January-March 2012 (validation cohort, n = 3092), 270 patients were labelled with a notification. Of these patients, 82 (2.7 %) were diagnosed with a LRR. The notification method identified 63 patients (77 %) with LRRs.</div><div>Missed notifications were due to clinical diagnoses (not available in Palga, 53 %) or incomplete/incorrect pathological reporting (47 %). The notification method resulted in cost savings of €2.949.127,- as compared to the manual scenario.</div></div><div><h3>Conclusion</h3><div>Using the notification method, almost 80 % of the patients with LRRs were identified, with huge reductions in registration burden and costs. The incompleteness should be considered in future analyses. Improvement in pathology reporting could increase completeness.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102780"},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival predictors of older cancer patients in Bangladesh: A multicenter study","authors":"Muhammad Rafiqul Islam ,&nbsp;Syeda Masuma Siddiqua ,&nbsp;Salman Bashar Al Ayub ,&nbsp;Rashedul Islam ,&nbsp;Beauty Saha ,&nbsp;Mohammad Habibur Rahman ,&nbsp;Nazrina Khatun ,&nbsp;Izabela Ono Adriazola ,&nbsp;Mohammad Hasan Shahriar ,&nbsp;Muhammad Ashique Haider Chowdhury ,&nbsp;Saira Tasmin ,&nbsp;Andrew Craver ,&nbsp;Habibul Ahsan","doi":"10.1016/j.canep.2025.102794","DOIUrl":"10.1016/j.canep.2025.102794","url":null,"abstract":"<div><h3>Introduction</h3><div>The aging of the global population has led to an increased prevalence of cancer among older adults, particularly in Asia and in low- and middle-income countries. This demographic shift presents unique challenges to healthcare delivery, especially in developing countries like Bangladesh. This study aims to analyze survival outcomes and epidemiological patterns of elderly cancer patients in Bangladesh, addressing a critical knowledge gap in geriatric oncology in low- and middle-income countries</div></div><div><h3>Methods</h3><div>A 27-month prospective cohort study, conducted from October 2021 to January 2024 across three hospitals in Bangladesh, included 862 cancer patients aged 60 and older, 581 of whom completed the full study period. Demographic data, medical history, physical status, and treatment records were collected through questionnaires and follow-up. Survival analysis was performed using the Kaplan-Meier method and Cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>Of 581 patients with a mean age of 65.9 years, 67.47 % died during the study. Lung cancer was the most common diagnosis (43.5 %), while breast cancer patients had the highest survival rate of the cohort (56.61 %). Mortality risk slightly increased with age (HR 1.02, 95 % CI:1.01, 1.04, p = 0.04), while sex had no significant impact. Advanced stage cancer increased mortality risk (HR 1.67, 95 % CI:1.10, 2.54, p = 0.01), while adequate food intake (HR 0.47, 95 % CI:0.31, 0.72, p = 0.00), better mobility (HR 0.62, 95 % CI: 0.40, 0.94, p = 0.02), and positive health perception (HR 0.54, 95 % CI:0.38,0.75, p = 0.00), were linked to improved survival. Treatment with more than two drugs alongside platinum-based chemotherapy increased mortality (HR 2.03, 95 % CI:1.14, 3.63, p = 0.01) compared to non-platinum or oral drugs, while a history of post-diagnosis surgery was associated with reduced mortality. Comorbidities and BMI were not significant in the multivariate analysis.</div></div><div><h3>Conclusion</h3><div>The study underscores the need for comprehensive, individualized care plans for older cancer patients, considering both the type of cancer and the patient's overall health. Future research should focus on optimizing treatment strategies and care models tailored to older cancer patients in resource-limited settings.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102794"},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and survival of patients with melanoma in Colombia","authors":"Henry Oliveros ,&nbsp;Juliana Usta Stavoli ,&nbsp;Nadia Juliana Proaños ,&nbsp;Julio Roberto Amador ,&nbsp;Luis Felipe Reyes","doi":"10.1016/j.canep.2025.102784","DOIUrl":"10.1016/j.canep.2025.102784","url":null,"abstract":"<div><h3>Background</h3><div>Melanoma accounts for less than 2 % of all skin cancers but exhibits highly aggressive behaviour, rapidly leading to metastasis. Various individual and environmental risk factors are associated with its occurrence.</div></div><div><h3>Methods</h3><div>A cohort study was conducted using data from the Integrated Social Protection Information System (SISPRO) of the Colombian Ministry of Health. Patients with newly diagnosed melanoma in 2019 were included. Demographic, clinical, and mortality characteristics were analysed, and crude and age- and sex-adjusted incidence rates were calculated. The association between the altitude of populations and melanoma rates was evaluated using Pearson’s correlation coefficient and an analysis of variance. The Fine and Gray model was used to estimate survival.</div></div><div><h3>Results</h3><div>In 2019, 5255 new cases of melanoma were reported in the health insurance system. The crude incidence rate was 22 cases per 100,000 inhabitants, and the age-adjusted incidence rate was 21. The overall three-year mortality rate was 18.8 %, with melanoma-attributable mortality at 7 %. As expected, the mortality rate was higher in patients with invasive melanoma, COPD, and among men. Melanoma rates were positively correlated with greater exposure to UV radiation, determined by the altitude of the municipalities.</div></div><div><h3>Conclusion</h3><div>Colombia has high melanoma incidence rates, with significant regional variations. UV radiation exposure and altitude are key factors.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102784"},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radon exposure and cancer burden: A regional spatial analysis in Finland","authors":"Saqib Amin","doi":"10.1016/j.canep.2025.102783","DOIUrl":"10.1016/j.canep.2025.102783","url":null,"abstract":"<div><div>This study investigates the regional disparities in the association between radon exposure and cancer burdens in Finland using spatial panel data analysis. We analyze data from 19 Finnish regions spanning the years 1990–2023, focusing on variations in radon concentrations and their association with regional cancer incidence and mortality rates. Our approach integrates both temporal and spatial dimensions, allowing for a comprehensive assessment of the relationship between radon exposure levels and cancer outcomes while accounting for regional heterogeneity and spatial dependencies. The results suggest a significant positive association between elevated radon exposure and increased cancer incidence and mortality, with notable regional differences in the strength of this effect. The findings have important implications for public health interventions and policies aimed at reducing radon exposure and mitigating its cancer-related risks in Finland and other radon-prone regions.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102783"},"PeriodicalIF":2.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive appraisal of the association between sexually transmitted infections and prostate cancer: A scoping review of empirical studies, reviews, and meta-analyses","authors":"Rodrigo Noorani,&nbsp;Sarah Botting-Provost,&nbsp;George Kas Barsoum,&nbsp;Cassandra Laurie,&nbsp;Mariam El-Zein,&nbsp;Eduardo L. Franco","doi":"10.1016/j.canep.2025.102781","DOIUrl":"10.1016/j.canep.2025.102781","url":null,"abstract":"<div><div>We performed a scoping review on the association of sexually transmitted infections (STIs) with prostate cancer and identified knowledge gaps. Searching four databases (Medline, Embase, Scopus, and Cochrane) identified 286 eligible records. Most empirical studies (n = 191) were cross-sectional (n = 66) and case-control (n = 52). The most studied STIs were human papillomavirus (HPV) (n = 82), human immunodeficiency virus (HIV) (n = 52), and herpes simplex virus (HSV) (n = 30). We included 68 narrative reviews, 10 systematic reviews, and 17 meta-analyses. Most effect estimates (odds ratios, hazard ratios, risk ratios and standardised incidence ratios) did not support an association between STIs and prostate cancer: 373 and 218 of 591 effect estimates were above and below the null, respectively, except for HIV where 74 of 108 estimates were below the null. Knowledge gaps included case-control studies, insights into HIV-related mechanisms for a lower risk for prostate cancer, studies on <em>Mycoplasma</em> and <em>Ureaplasma</em>, studies adjusting for co-infection with other STIs, and studies assessing whether STIs predispose men to a more aggressive form of prostate cancer. A key research priority identified is the need for more evidence on the biological mechanisms driving infection-mediated prostate carcinogenesis.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"96 ","pages":"Article 102781"},"PeriodicalIF":2.4,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of survival in women diagnosed with breast cancer between 2008 and 2017: An analysis of a cohort using data from four Population-Based Cancer Registries of Colombia","authors":"Karen Cárdenas-Garzón ,&nbsp;Daniel Jurado ,&nbsp;Karen Coronell ,&nbsp;Karen Florez-Lozano ,&nbsp;Nelson Arias-Ortiz ,&nbsp;Luisa M. Bravo ,&nbsp;Claudia Uribe-Perez ,&nbsp;Edgar Navarro-Lechuga ,&nbsp;Gloria I. Sanchez","doi":"10.1016/j.canep.2025.102765","DOIUrl":"10.1016/j.canep.2025.102765","url":null,"abstract":"<div><h3>Background</h3><div>Breast Cancer (BC) is the leading cause of cancer-related mortality in women, especially in low- and middle-income countries. Population-Based Cancer Registries (PBCRs) play a crucial role in monitoring cancer trends and guiding evaluation and planning of cancer control programs. In Colombia, there are no national analyses of BC survival. The aim was to estimate the overall survival up to 5-year of women diagnosed with BC, as well as its determinants, in Colombia using population-based data from four Colombian PBCRs.</div></div><div><h3>Methods</h3><div>We conducted a cohort study with women diagnosed with invasive BC between 2008 and 2017, identified by the corresponding PBCRs as residents of the Colombian cities of Barranquilla, Bucaramanga metropolitan area, Manizales, and Pasto. We performed follow-up up to 5 years after the BC diagnosis, or until death (all-cause). We estimated the overall survival (Kaplan Meier). We evaluated the simultaneous effect of multiple risk factors on death risk using Cox proportional hazards analysis, obtaining adjusted Hazard Ratios (aHR) and Confidence Intervals (CI).</div></div><div><h3>Results</h3><div>The analysis cohort included 8020 BC cases. The observed overall survival was 72.5 %. The likelihood of 5-year survival was lowest for women aged 70 or older (aHR 1.61; 95 % CI 1.42–1.83), those living in a middle Socioeconomic Stratum (SES) (aHR 1.32; 95 % CI 1.05–1.66), those affiliated to the subsidized Health Insurance Regime (HIR) (aHR 1.47; 95 % CI 1.32–1.63), and those diagnosed in stages III-IV (aHR 2.29; 95 % CI 2.03–2.57) compared to women with a diagnosis age between 50 and 70 years, residents in high SES, those affiliated to the contributory HIR, and those diagnosed at stages I-II, respectively.</div></div><div><h3>Conclusion</h3><div>Social disparities are linked to BC survival in Colombia, likely due to limited access to healthcare services. This suggests the importance of strengthening screening and diagnostic care, especially for vulnerable populations.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"95 ","pages":"Article 102765"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}