Cancer Epidemiology最新文献_第6页

Understanding female breast cancer risk in the Indian population: Evidence from a systematic review and meta-analysis 了解印度人群中的女性乳腺癌风险：来自系统回顾和荟萃分析的证据。

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.canep.2025.102979

Saravanan Vijayakumar, Thilagavathi Ramamoorthy , Abhishek David George, Anita Nath

{"title":"Understanding female breast cancer risk in the Indian population: Evidence from a systematic review and meta-analysis","authors":"Saravanan Vijayakumar, Thilagavathi Ramamoorthy , Abhishek David George, Anita Nath","doi":"10.1016/j.canep.2025.102979","DOIUrl":"10.1016/j.canep.2025.102979","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer incidence in India is expected to rise by about 5.6 % annually, translating to an estimated increase of 0.05 million new cases per year. This systematic review and meta-analysis aim to investigate the influence of India's unique context on breast cancer risk by identifying and synthesising population-specific risk factors.</div></div><div><h3>Methods</h3><div>We conducted a systematic literature search across the PubMed, Scopus, and Embase databases up to December 22, 2024. Observational studies assessing breast cancer risk factors among Indian women were included, and quality was assessed using the Joanna Briggs Institute Checklist. A meta-analysis using a random-effects model estimated pooled associations between key risk factors and breast cancer.</div></div><div><h3>Results</h3><div>Among the 1871 articles identified, 31 studies met the inclusion criteria of which case-control studies were of moderate to high quality. The meta-analysis revealed significant positive associations with breast cancer risk for late menopause (age >50 years), delayed first pregnancy or childbirth (age >30 years), multiple abortions, higher age at marriage, increased waist-to-hip ratio (≥0.85), and family history of cancer, particularly breast cancer. Among lifestyle factors, poor sleep quality, irregular sleep patterns, sleeping in a lighted room, and elevated stress levels were also positively associated with risk in individual studies. In contrast, higher levels of physical activity showed an inverse association.</div></div><div><h3>Conclusions</h3><div>Reproductive timing, hormonal exposure, central obesity, and family history influence breast cancer risk primarily among Indian women. In conclusion, the review highlights the critical need for large, extensive, population-based prospective cohort studies in India to define breast cancer prevention and early detection strategies with greater precision.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"100 ","pages":"Article 102979"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer in the oldest old 癌症发生在最老的时候

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.canep.2025.102980

Charline Jean, Esther Bastiaannet, Melody K. Schiaffino, Sophie Pilleron , Florence Canouï-Poitrine

引用次数: 0

Association between blood cholesterol profile and risk of lung cancer: A meta-analysis of prospective cohort studies 血胆固醇与肺癌风险之间的关系：前瞻性队列研究的荟萃分析。

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI: 10.1016/j.canep.2025.102955

Anindita Bhattacharya , Ritabrata Mitra , Ankan Bandyopadhyay , Amitabha Sengupta , Koel Chaudhury

{"title":"Association between blood cholesterol profile and risk of lung cancer: A meta-analysis of prospective cohort studies","authors":"Anindita Bhattacharya , Ritabrata Mitra , Ankan Bandyopadhyay , Amitabha Sengupta , Koel Chaudhury","doi":"10.1016/j.canep.2025.102955","DOIUrl":"10.1016/j.canep.2025.102955","url":null,"abstract":"<div><div>Research findings on the relationship between blood cholesterol levels and lung cancer (LC) risk have been inconsistent, leading to inconclusive evidence regarding a definitive association. The present meta-analysis aimed to comprehensively assess the association of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) with the risk of LC, taking into consideration all relevant prospective cohort studies. Three databases (PubMed, Scopus, and Web of Science) were systematically searched from January 2005 to Dec 2024 to identify potentially relevant articles. This meta-analysis included articles reporting the hazard ratio (HR) with a 95 % confidence interval (CI) for the highest vs. lowest categories of at least one blood cholesterol component (TC, HDL-C, or LDL-C) or sufficient data to calculate the same in relation to the risk of LC. Based on the eligibility criteria, a total of 13 prospective cohort studies involving 2,718,010 individuals and 24,842 LC cases were included. The main analysis revealed a significant inverse association between HDL-C and the risk of LC (pooled HR = 0.83, 95 % CI: 0.74–0.92). No statistically significant associations were observed for TC or LDL-C in relation to LC risk. In conclusion, higher HDL-C levels appear to be significantly associated with a lower risk of LC, whereas no significant associations is evident for TC or LDL-C. Maintaining healthy HDL-C levels through a balanced diet and regular exercise may help reduce LC incidence. Nonetheless, further large-scale prospective studies with adequate adjustment for confounding and preclinical bias are warranted to ascertain the potential causality.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102955"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description and recent trends (2011–2019) of early-onset colorectal cancer incidence in Texas 德克萨斯州早发性结直肠癌发病率描述及近期趋势（2011-2019）

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-09-16 DOI: 10.1016/j.canep.2025.102927

Yahan Zhang , Hyeun Ah Kang , Srinivas Joga Ivatury , Claire Sokas

{"title":"Description and recent trends (2011–2019) of early-onset colorectal cancer incidence in Texas","authors":"Yahan Zhang , Hyeun Ah Kang , Srinivas Joga Ivatury , Claire Sokas","doi":"10.1016/j.canep.2025.102927","DOIUrl":"10.1016/j.canep.2025.102927","url":null,"abstract":"<div><h3>Background</h3><div>Early-onset colorectal cancer (EO-CRC), diagnosed in individuals under 50, has seen rising incidence rates, while average-onset colorectal cancer rates decline. To understand EO-CRC burden across regions and patient characteristics, detailed incidence data are essential. With Texas's large population and unique demographics, this study examines recent trends in age-adjusted EO-CRC incidence.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis used 2011–2019 Texas Cancer Registry (TCR) data. The incidence rate of EO-CRC was adjusted to the 2000 US standard population and was stratified by cancer type, sex, race/ethnicity, and stage at diagnosis. The number of EO-CRC cases between 2011 and 2019 was mapped to the Texas counties.</div></div><div><h3>Results</h3><div>In the study period, a total of 11,848 EO-CRC (7511 colon cancer [EO-CC] and 4337 rectal cancer [EO-RC]) cases were identified. Over 50 % of cases were diagnosed before the age of 45. The age-adjusted incidence rate (AAIR) of EO-CRC showed a slightly increasing trend over the study period (AAIR range: 10.4/100,000 persons [95 % CI = 9.8–11.0]- 12.7/100,000 persons [95 % CI = 12.0–13.3]). The AAIRs of EO-CRC among males were higher than that of females. Non-Hispanic (NH) White population had the highest AAIR, followed by the Black population and Hispanic population, while other races/ethnicities had the lowest AAIR of EO-CRC. The incidence rate of EO-CRC diagnosed at the regional stage was the highest and showed the steepest increasing trend. While EO-CRC case density by county reflects the population density, incidence rates were higher in rural counties.</div></div><div><h3>Conclusion</h3><div>The incidence of EO-CRC in Texas showed an increasing trend from 2011 to 2019, with notable disparities by sex, race/ethnicity, and cancer stage.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102927"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium intake and gastric cancer risk: A systematic review and dose–response meta-analysis of observational studies 钙摄入与胃癌风险：观察性研究的系统回顾和剂量反应荟萃分析

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI: 10.1016/j.canep.2025.102939

Alex Richard Costa Silva , Marcela de Araújo Fagundes , Valdete Regina Guandalini , Maria Paula Curado

{"title":"Calcium intake and gastric cancer risk: A systematic review and dose–response meta-analysis of observational studies","authors":"Alex Richard Costa Silva , Marcela de Araújo Fagundes , Valdete Regina Guandalini , Maria Paula Curado","doi":"10.1016/j.canep.2025.102939","DOIUrl":"10.1016/j.canep.2025.102939","url":null,"abstract":"<div><div>Calcium has been proposed as a protective factor against certain types of cancer, but findings related to gastric cancer (GC) are inconsistent. This meta-analysis aimed to assess the association between calcium intake and the risk of GC. A comprehensive search was conducted in PubMed, Scopus, EMBASE, LILACS, and Web of Science for cohort and case-control studies published up to August 19, 2024. The quality of the studies was assessed using the Newcastle–Ottawa Scale. Publication bias was tested using Egger’s and Begg’s tests. Relative risks (RRs) and 95 % confidence intervals (CIs) were pooled through a random-effects model. Given the substantial heterogeneity and potential variation in intake levels across populations, a dose-response analysis was conducted to explore potential trends across the full range of calcium consumption. Thirteen studies involving 1,610,992 participants met the inclusion criteria. A non-significant inverse association was observed between total calcium intake and GC risk when comparing the highest vs lowest intake categories (RR: 0.85; 95 % CI: 0.70–1.05). While this categorical comparison was not statistically significant, the dose-response analysis revealed a significant linear protective effect, with a 10 % reduction in risk per 300 mg/day increase in dietary calcium intake (RR: 0.90; 95 % CI: 0.82–0.99). To account for potential variations across intake levels, a non-linear model was also applied, indicating a clearer risk reduction above 400 mg/day (p for non-linearity < 0.001). Overall, this dose-response meta-analysis suggests that higher dietary calcium intake may have a protective effect against GC, reinforcing the importance of considering calcium in dietary strategies for GC prevention, although more studies are needed to confirm these findings.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102939"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intersection of climate change and cancer across global populations: A bibliometric analysis (2000–2024) 全球人口中气候变化和癌症的交集：文献计量分析（2000-2024）。

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.canep.2025.102926

Shibaji Gupta , Priyadharshini Babu , Debdutta Haldar , Subhadip Bag , Ilham Zaidi , Sonu Goel

{"title":"The intersection of climate change and cancer across global populations: A bibliometric analysis (2000–2024)","authors":"Shibaji Gupta , Priyadharshini Babu , Debdutta Haldar , Subhadip Bag , Ilham Zaidi , Sonu Goel","doi":"10.1016/j.canep.2025.102926","DOIUrl":"10.1016/j.canep.2025.102926","url":null,"abstract":"<div><h3>Background</h3><div>The convergence of climate change and cancer is an emerging research area with significant implications for public health. This bibliometric analysis aimed to map the growth, trends, contributors, collaboration networks, and thematic areas related to this field.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed and Scopus databases for peer-reviewed literature published between 2000 and 2024 using predefined keywords. One-hundred and nineteen eligible articles were analyzed for metrics like co-authorship networks and keywords co-occurrence.</div></div><div><h3>Results</h3><div>The volume of research has seen a significant rise since the 2010s. The United States, China, and the United Kingdom were leading contributors, while the Low- and Middle-Income Countries were underrepresented. Dominant research themes included climate change and cancer, pollution and cancer, sun exposure, temperature and skin cancer, and air pollution and climate change. Air pollution and particulate matter were identified as high-density and centrality motor themes.</div></div><div><h3>Conclusion</h3><div>This analysis provides a first-of-its-kind mapping of 2 decades of global research at the intersection of climate change and cancer. Future research should prioritize global South perspectives, context-specific investigations, and longitudinal studies integrating registry data for in-depth studies to elucidate the causal relationships between climate change and cancer types. The oncology community should engage in climate action through mitigation and adaptation strategies.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102926"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and disparities in locoregional treatment of programme-detected ductal carcinoma in situ in New Zealand women, 1999–2022 1999-2022年新西兰妇女原位导管癌局部区域治疗的趋势和差异

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.canep.2025.102934

Qian Chen , Ian Campbell , Mark Elwood , Alana Cavadino , Phyu Sin Aye , Sandar Tin Tin

{"title":"Trends and disparities in locoregional treatment of programme-detected ductal carcinoma in situ in New Zealand women, 1999–2022","authors":"Qian Chen , Ian Campbell , Mark Elwood , Alana Cavadino , Phyu Sin Aye , Sandar Tin Tin","doi":"10.1016/j.canep.2025.102934","DOIUrl":"10.1016/j.canep.2025.102934","url":null,"abstract":"<div><h3>Purpose</h3><div>Ethnic and socioeconomic disparities exist in treatment of invasive breast cancer in New Zealand. This study investigated trends and disparities in locoregional treatment of ductal carcinoma in situ (DCIS) detected by BreastScreen Aotearoa (BSA), the national breast screening programme.</div></div><div><h3>Methods</h3><div>Women with programme-detected DCIS from 1999 to 2022 were identified from BSA records linked to the national cancer registry and hospital discharge records. Logistic regression identified associated factors.</div></div><div><h3>Results</h3><div>Of the 6087 cases identified, 39.7 % received breast-conserving surgery (BCS) with radiotherapy (RT), 31.5 % had mastectomy and 28.8 % had BCS alone. BCS with RT increased from 27.6 % in 1999 to 41.1 % in 2006, followed by a modest increase to 46.7 % in 2022, while mastectomy decreased from 33.3 % in 1999 to 25.4 % in 2022. The post-BCS RT use was less common among Pacific women. Sentinel lymph node biopsy (SLNB) increased from 6.2 % in 2004 (when it was implemented nationwide) to 26.0 % in 2007, then reached 37.1 % in 2013, before declining to 24.5 % in 2022. Pacific and Asian women who had mastectomy were more likely to have SLNB. Immediate breast reconstruction (IBR) after a mastectomy increased from 11.4 % in 1999 to 39.8 % in 2009, then underwent a modest decline to 22.7 % in 2022. Māori, older women, and those living in the deprived or rural areas were less likely to receive IBR.</div></div><div><h3>Conclusion</h3><div>Locoregional treatment for programme-detected DCIS has improved over time; however, ethnic and socioeconomic disparities persist, underscoring the need to improve equity of cancer care in New Zealand.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102934"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological trends of lymphoma in Sri Lanka: A national cancer registry study (2005–2021) 斯里兰卡淋巴瘤的流行病学趋势：一项国家癌症登记研究（2005-2021）

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.canep.2025.102951

Bhawani Yasassri Alvitigala, Lallindra Viranjan Gooneratne, Chandu de Silva

{"title":"Epidemiological trends of lymphoma in Sri Lanka: A national cancer registry study (2005–2021)","authors":"Bhawani Yasassri Alvitigala, Lallindra Viranjan Gooneratne, Chandu de Silva","doi":"10.1016/j.canep.2025.102951","DOIUrl":"10.1016/j.canep.2025.102951","url":null,"abstract":"<div><h3>Background</h3><div>Globally, lymphoma incidence has been steadily rising, with notable regional and gender-based variations. Understanding these trends in developing countries like Sri Lanka is essential to address cancer control strategies.</div></div><div><h3>Methodology</h3><div>Cancer incidence and mortality data from the National Cancer Control Program (NCCP) registries (2005–2021) were analyzed. Temporal trends in age-standardized rates (ASR) were assessed using Joinpoint Regression to estimate annual percent change (APC) and average APC (AAPC).</div></div><div><h3>Results</h3><div>A total of new 15,577 lymphoma cases were reported with male predominance (60 %, n = 9346) and non-Hodgkin lymphoma (NHL) being the predominant subtype (79 %, n = 9561). The overall incidence increased significantly over 16 years (AAPC: 4.1 %; p < 0.05), with a 1.4-fold rise in both sexes and a marked rise among 0–19-year-olds, exclusively post-2019 (p < 0.05). NHL incidence was highest in individuals aged ≥ 60 years, with a 2-fold rise in both gender (APC: 3.2; 95 % CI: 0.4 – 6.1; p < 0.05) during 2011–2021. Hodgkin lymphoma (HL) showed a significant 3-fold increase in females, while trends in males fluctuated, with a significant average AAPC in both sexes from 2011 to 2021 (p < 0.05). Despite the non-significant rise in female incidence across most age groups, males in 40–59 and > 60 years age groups showed a decline. A significant rise in NHL-related deaths among males (p < 0.05) was noted, with a non-significant increase in females.</div></div><div><h3>Conclusions</h3><div>Our findings indicate an apparent rising burden of lymphoma in Sri Lanka, particularly among males and the elderly. However, this observed increase may be partly attributable to improvements in cancer diagnostics and NCCP reporting over time. Additionally, evolving WHO classifications and their gradual adoption may also have influenced the observed trends.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102951"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors of Mucoepidermoid Carcinoma within the head and neck: A NCDB analysis 头颈部黏液表皮样癌的预后因素：NCDB分析。

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.canep.2025.102945

Sebastian Respicio , Daniel Ryan , Christopher Bine , Stone Zhang , Peter Silberstein , Marco DiBlasi

{"title":"Prognostic factors of Mucoepidermoid Carcinoma within the head and neck: A NCDB analysis","authors":"Sebastian Respicio , Daniel Ryan , Christopher Bine , Stone Zhang , Peter Silberstein , Marco DiBlasi","doi":"10.1016/j.canep.2025.102945","DOIUrl":"10.1016/j.canep.2025.102945","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize the prognostic profile of head and neck Mucoepidermoid Carcinoma (MEC) and correlate findings with survival and surgical likelihood.</div></div><div><h3>Methods</h3><div>This retrospective cohort study queried the National Cancer Database from 2004 to 2021 for all head and neck structures with histologically confirmed MEC. Using SPSS and GraphPad Prism, statistical analyses were conducted via Kaplan Meier Survival with Log-Rank Pairwise Comparisons, Cox Proportional Hazards Regressions, and Binomial and Multinomial Logistic Regressions.</div></div><div><h3>Results</h3><div>A total of 17,713 patients were included. Significant findings include worsened overall survival (OS) and hazard ratios (HR) in relation to male sex, white race, non-Hispanic ethnicity, non-Private Insurances, non-Academic/Research treatment facilities, and not undergoing surgery. MEC in the Gum & Other Mouth and in the Lip had better OS and HR while MEC of the Nose, Nasal Cavity, & Middle Ear, MEC of the Tongue, and MEC of the Pharynx had worsened OS and HR in comparison to Salivary Gland MEC. Gum & Other Mouth MEC patients had significantly increased likelihood for Local Tumor Excision and Partial Organ Removal surgeries. Tongue MEC had significantly increased likelihood for Partial Organ Removal. Nose, Nasal Cavity, & Middle Ear MEC and Pharynx MEC had significantly decreased likelihoods for Local Tumor Excision or Total/Radical Organ Removal Surgeries.</div></div><div><h3>Conclusion</h3><div>By identifying key determinants of survival and surgical likelihood, this work provides valuable clinical insight into patient management and outcomes for a clinically significant malignancy. Additionally, this study comments on the role of accessible surgical care and social determinants of health regarding MEC.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102945"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional assessment of US cancer diagnoses during the COVID-19 pandemic COVID-19大流行期间美国癌症诊断的横断面评估

IF 2.3 3区医学

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.canep.2025.102944

Todd Burus , Uriel Kim , Johnie Rose , Siran M. Koroukian , Krystle A. Lang Kuhs

{"title":"A cross-sectional assessment of US cancer diagnoses during the COVID-19 pandemic","authors":"Todd Burus , Uriel Kim , Johnie Rose , Siran M. Koroukian , Krystle A. Lang Kuhs","doi":"10.1016/j.canep.2025.102944","DOIUrl":"10.1016/j.canep.2025.102944","url":null,"abstract":"<div><h3>Background</h3><div>Disruptions to cancer diagnoses were widely reported in the US during the early COVID-19 pandemic. Whether any cases remained unaccounted-for by the end of the pandemic has not been fully assessed.</div></div><div><h3>Methods</h3><div>We collected data on invasive cancer diagnoses occurring among individuals aged 20–89 years between January 2020 and December 2022 from the Surveillance, Epidemiology, and End Results database. Expected cancer case counts and incidence rates with 95 % credibility intervals (95 %CrIs) were estimated for 2020–2022 from pre-pandemic trends (2005–2019) using Bayesian Age-Period-Cohort models. We compared observed rates with expected rates, and estimated unaccounted-for cases. Additional site-, stage-, and subgroup-specific analyses were performed.</div></div><div><h3>Results</h3><div>Among 2260,704 cancer cases diagnosed in 2020–2022, the observed incidence rate was 595.5 per 100,000 persons (95 %CI, 594.7–596.2), which was 6.7 % lower than the expected rate of 638.1 (95 %CrI, 620.1–656.1) and corresponded to 160,475 fewer-than-expected cases (95 %CrI, 99,777–221,174). Annual observed rates were significantly lower than expected in 2020 (565.8 vs. 630.7), with recovery in 2021 and 2022, though not enough to overcome the existing case deficit. Incidence rates for persons aged ≥ 65 years, nonmetropolitan residents, and non-Hispanic White individuals, as well as site-specific rates for lung and kidney cancers and non-Hodgkin lymphoma, remained below expected levels beyond 2020. Early-stage colorectal cancer diagnoses were 14.2 % lower than expected over the period.</div></div><div><h3>Conclusion</h3><div>While annual cancer incidence rates returned to expected levels by the end of the COVID-19 pandemic, substantial numbers of unaccounted-for cases remained, raising concerns for future increases in cancer morbidity and mortality.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102944"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0