Prognostic factors of Mucoepidermoid Carcinoma within the head and neck: A NCDB analysis

IF 3 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI:10.1016/j.canep.2025.102945

Sebastian Respicio , Daniel Ryan , Christopher Bine , Stone Zhang , Peter Silberstein , Marco DiBlasi

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引用次数: 0

Abstract

Objectives

To characterize the prognostic profile of head and neck Mucoepidermoid Carcinoma (MEC) and correlate findings with survival and surgical likelihood.

Methods

This retrospective cohort study queried the National Cancer Database from 2004 to 2021 for all head and neck structures with histologically confirmed MEC. Using SPSS and GraphPad Prism, statistical analyses were conducted via Kaplan Meier Survival with Log-Rank Pairwise Comparisons, Cox Proportional Hazards Regressions, and Binomial and Multinomial Logistic Regressions.

Results

A total of 17,713 patients were included. Significant findings include worsened overall survival (OS) and hazard ratios (HR) in relation to male sex, white race, non-Hispanic ethnicity, non-Private Insurances, non-Academic/Research treatment facilities, and not undergoing surgery. MEC in the Gum & Other Mouth and in the Lip had better OS and HR while MEC of the Nose, Nasal Cavity, & Middle Ear, MEC of the Tongue, and MEC of the Pharynx had worsened OS and HR in comparison to Salivary Gland MEC. Gum & Other Mouth MEC patients had significantly increased likelihood for Local Tumor Excision and Partial Organ Removal surgeries. Tongue MEC had significantly increased likelihood for Partial Organ Removal. Nose, Nasal Cavity, & Middle Ear MEC and Pharynx MEC had significantly decreased likelihoods for Local Tumor Excision or Total/Radical Organ Removal Surgeries.

Conclusion

By identifying key determinants of survival and surgical likelihood, this work provides valuable clinical insight into patient management and outcomes for a clinically significant malignancy. Additionally, this study comments on the role of accessible surgical care and social determinants of health regarding MEC.

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头颈部黏液表皮样癌的预后因素：NCDB分析。

目的：探讨头颈部黏液表皮样癌（MEC）的预后特征，并将其与生存和手术可能性联系起来。方法：这项回顾性队列研究查询了2004年至2021年国家癌症数据库中所有组织学证实的MEC头颈部结构。使用SPSS和GraphPad Prism进行Kaplan Meier生存分析，采用Log-Rank两两比较、Cox比例风险回归、二项和多项Logistic回归进行统计分析。结果：共纳入17713例患者。重要的发现包括与男性、白人、非西班牙裔、非私人保险、非学术/研究治疗设施和未接受手术相关的总生存率（OS）和风险比（HR）恶化。与唾液腺MEC相比，牙龈及其他口腔和唇部MEC的OS和HR较好，而鼻、鼻腔和中耳MEC、舌部MEC和咽部MEC的OS和HR较差。牙龈和其他口腔MEC患者进行局部肿瘤切除和部分器官切除手术的可能性显著增加。舌MEC明显增加部分器官切除的可能性。鼻、鼻腔、中耳MEC和咽MEC进行局部肿瘤切除或全/根治性器官切除手术的可能性显著降低。结论：通过确定生存和手术可能性的关键决定因素，这项工作为临床显著恶性肿瘤的患者管理和结果提供了有价值的临床见解。此外，本研究还评论了外科护理的可及性和MEC健康的社会决定因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.