Cancer Epidemiology最新文献

{"title":"Evaluating sex-specific prediction models for colorectal cancer risk using a genome-wide polygenic risk score and lifestyle factors in a Japanese population","authors":"Shiori Nakano ,&nbsp;Taiki Yamaji ,&nbsp;Tsuyoshi Hachiya ,&nbsp;Aya Kuchiba ,&nbsp;Atsushi Shimizu ,&nbsp;Norie Sawada ,&nbsp;Manami Inoue ,&nbsp;Shoichiro Tsugane ,&nbsp;Motoki Iwasaki ,&nbsp;for the Japan Public Health Center-based Prospective Study Group","doi":"10.1016/j.canep.2025.102878","DOIUrl":"10.1016/j.canep.2025.102878","url":null,"abstract":"<div><h3>Background</h3><div>The predictive performance of a colorectal cancer (CRC) risk prediction model incorporating genome-wide polygenic risk scores (PRSs) and lifestyle factors remains unclear in Asian populations. This study aimed to develop and evaluate the Asian-specific models using a Japanese population-based prospective study.</div></div><div><h3>Methods</h3><div>We derived 31 genome-wide PRSs using a genome-wide association study of CRC from the Biobank Japan and selected the best-performing PRS with the highest C-index in development case-cohort, including 200 incident cases. In evaluation case-cohort, including 693 incident cases, we assessed the discrimination accuracy (C-index, integrated discrimination improvement (IDI), and net reclassification improvement (NRI)) of lifestyle, PRS, and combined models using 5-fold cross-validation methods and estimated 10-year absolute risk.</div></div><div><h3>Results</h3><div>Of the 31 derived PRSs, the PRS aggregating 104,677 variant risks performed best in the development case-cohort. The men and women in the highest quintiles of the PRS had an approximately three-fold and two-fold higher risk of CRC, respectively, than those in the lowest in the evaluation case-cohort. Meanwhile, the association of lifestyle factors with CRC risk was observed only in men. Incorporating the PRS into a lifestyle model improved the C-index from 0.64 to 0.66 for men and from 0.61 to 0.63 for women. The IDI and NRI values supported this improvement. The 10-year absolute risk was 3.3 % and 1.6 % for high-risk men and women, respectively, and 0.5 % for both low-risk men and women.</div></div><div><h3>Conclusions</h3><div>This study suggests that the CRC risk prediction model utilizing genome-wide PRS for Asians is valuable; however, further improvement is needed before clinical implementation.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"Article 102878"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of type 2 diabetes and its complications with the risk of colorectal cancer","authors":"Eetu Mäkinen ,&nbsp;Sanna Heikkinen ,&nbsp;Janne Pitkäniemi ,&nbsp;Karri Seppä","doi":"10.1016/j.canep.2025.102879","DOIUrl":"10.1016/j.canep.2025.102879","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of type 2 diabetes (T2D) has increased worldwide during the 21st century. T2D and colorectal cancers (CRC) share risk factors such as obesity. This study aims to estimate the association between T2D and the incidence of primary CRC, and furthermore the association of diabetic complications with the risk of CRC.</div></div><div><h3>Methods</h3><div>We linked exposure data on T2D by severity (presence or absence of complications), overweight and obesity and alcohol related disorders from Care Register for Health Care and CRC cases from the Finnish Cancer Registry to a random sample of 2.5 million Finnish individuals of all ages that were followed from 2000 to 2017. To account for the cumulative burden of exposures, we employed a multi-state model where transition rates to CRC were modeled with Poisson regression, adjusted for age, calendar period, sex, overweight and obesity and alcohol related disorders.</div></div><div><h3>Results</h3><div>The cohort included 171,789 people diagnosed with T2D, with a median age of 67.6 at diagnosis. From the 23 533 CRCs diagnosed in the entire cohort, 2430 were in people with diabetes. Individuals diagnosed with T2D were at a higher risk of CRC (Hazard ratio 1.26, 95 % confidence interval 1.20–1.32). Persons with diabetic complications had a higher risk of CRC than those without complications after 10 years since the initial T2D diagnosis (1.21, 1.02–1.45, p = 0.033). Men with diabetic nephropathy had a significantly higher risk of CRC (1.51, 1.23–1.86) than men with diabetes without nephropathy.</div></div><div><h3>Conclusion</h3><div>Our research shows that people with uncomplicated T2D are at an increased risk of CRC in the first 10 years after T2D diagnosis. The risk of CRC among individuals with complicated T2D remains elevated also in longer term follow-up.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"Article 102879"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic access to colonoscopy, neighborhood social vulnerability, and associations with late-stage colorectal cancers in Maryland: 2010–2021","authors":"Samuel Roubin ,&nbsp;Broderick Yoerg ,&nbsp;Michael R. Desjardins","doi":"10.1016/j.canep.2025.102880","DOIUrl":"10.1016/j.canep.2025.102880","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of colorectal cancer (CRC) significantly improves survival. However, geographic inaccessibility of colonoscopies may prevent timely and effective screenings. The relationship between spatial access to colonoscopy providers, social determinants of health, and stage at CRC diagnosis remains understudied. We evaluated how place-based factors and individual characteristics are related to CRC diagnosis stage.</div></div><div><h3>Methods</h3><div>This cross-sectional, population-based study includes all CRC patients aged 50–84 at diagnosis between 2010 and 2021 from the Maryland Department of Health’s Cancer Registry (n = 21,599). We measured the spatial (geographic) accessibility to colonoscopy providers across Maryland at the census tract level using the Enhanced Two-Step Floating Catchment Area (E2SFCA) method. Multilevel logistic regression models were used to examine associations between late-stage CRC diagnosis and spatial accessibility, four census tract-level social vulnerability themes, rurality, and individual-level covariates.</div></div><div><h3>Results</h3><div>Among colorectal cancer cases with known stage (n = 19,239), 63.2 % (n = 12,151) were diagnosed at late-stage. Increasing socioeconomic vulnerability quartiles were associated with greater odds of late-stage diagnosis (Q4 vs Q1: OR, 1.17; 95 % CI, 1.04–1.32), while rural residence was associated with lower odds (OR, 0.69; 95 % CI, 0.59–0.80). Geographic access to colonoscopy providers was not significantly associated with late-stage diagnosis.</div></div><div><h3>Conclusion</h3><div>Findings suggest that non-spatial accessibility factors and place-based social determinants of health are more important than geographic access alone in influencing risk of late-stage colorectal cancer diagnosis. Public health interventions in Maryland should aim to target communities of high social vulnerability, particularly those with low socioeconomic status. Although our analysis is limited to Maryland, the results are broadly consistent with similar studies across U.S. settings and may be relevant in other states. Future studies should examine the barriers to CRC screening and diagnosis beyond geographic access.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"Article 102880"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharyngeal squamous cell carcinoma and risk of later esophageal squamous cell carcinoma – A nationwide population-based matched case-control study","authors":"Peter Elbe ,&nbsp;Isabella Ekheden ,&nbsp;Miroslav Vujasinovic ,&nbsp;John Maret-Ouda ,&nbsp;Elin Marsk ,&nbsp;Marcus Thuresson ,&nbsp;Weimin Ye ,&nbsp;Jonas F. Ludvigsson","doi":"10.1016/j.canep.2025.102876","DOIUrl":"10.1016/j.canep.2025.102876","url":null,"abstract":"<div><h3>Background</h3><div>Pharyngeal squamous cell carcinoma has been linked to later squamous cell carcinoma of the esophagus, but it is unclear if risks are similar to that of Barrett’s esophagus and would justify routine gastroscopy surveillance.</div></div><div><h3>Method</h3><div>Data on pharyngeal and esophageal cancers in 1980–2016 were retrieved through histopathology reports from Sweden’s 28 pathology departments and linked to national population-based healthcare registers. We calculated hazard ratios (HRs) for esophageal cancer and death in patients with pharyngeal carcinoma compared to a matched general population, and in a secondary analysis also compared to siblings of patients.</div></div><div><h3>Results</h3><div>We identified 1055 adults with pharyngeal cancer without prior or concomitant cancer. 78 % were men and median age at diagnosis of pharyngeal cancer was 64 years. During a median follow-up of 2.5 years four (0.4 %) patients developed esophageal squamous cell carcinoma, equal to 1 in 263 patients (HR = 14.3; 95 % CI = 1.6–132.3). In a competing risk analysis, the risk estimate for ESCC dropped and did not attain statistical significance (subdistribution HR=1.9 (95 % CI=0.7–5.2)). Some 855 patients (81 %) died during follow-up, representing a 7.7-fold increased risk of death among patients with pharyngeal cancer (Cox regression: HR=7.7; 95 % CI = 6.8–8.6).</div></div><div><h3>Conclusion</h3><div>The yearly risk of developing esophageal squamous cell carcinoma was 0.07 %. This is lower than in Barrett’s esophagus and argues against long-term endoscopic surveillance among patients with pharyngeal cancer.</div></div><div><h3>Level of Evidence</h3><div>3</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"Article 102876"},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute leukaemia: Patient factors associated with unplanned diagnostic pathways and the impact on survival – A nationwide register-based cohort study in Denmark","authors":"Line Flytkjær Virgilsen ,&nbsp;Peter Vedsted ,&nbsp;Henry Jensen ,&nbsp;Henrik Frederiksen ,&nbsp;Tarec Christoffer El-Galaly ,&nbsp;Anne Stidsholt Roug ,&nbsp;Linda Aagaard Rasmussen","doi":"10.1016/j.canep.2025.102874","DOIUrl":"10.1016/j.canep.2025.102874","url":null,"abstract":"<div><h3>Background</h3><div>Acute leukaemia (AL) is an aggressive haematological cancer. This study investigated patient factors in unplanned diagnostic pathways and the association with the prognosis and mortality of patients.</div></div><div><h3>Methods</h3><div>This nationwide register-based study included all patients diagnosed with AL in Denmark in 2014–2018. Diagnostic pathways were divided into elective pathways and unplanned pathways (acute admission within up to 30 days before diagnosis and no planned admissions).</div></div><div><h3>Results</h3><div>We included 1495 patients with AL. Diagnostic pathway did not differ by sociodemographic characteristics. Patients with a WHO performance score of 2–4 had a 64 % probability of being diagnosed in an unplanned pathway (95 % confidence interval (CI) 59–69 %) versus 47 % (95 % CI 44–50 %) in patients with a WHO performance score of 0–1. High comorbidity level was associated with higher probability of unplanned pathways. Patients in unplanned pathways had lower one-year survival than patients in elective pathways (adjusted all-cause mortality hazard ratio: 1.44 (95 % CI 1.29–1.62). This survival difference disappeared in landmark analyses with three-month delayed entry.</div></div><div><h3>Conclusions</h3><div>Patients with impaired performance score and high comorbidity level more often experienced an unplanned diagnostic pathway. Unplanned pathway was associated with lower survival and death within 3 months after the diagnosis.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"Article 102874"},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of the COVID-19 pandemic on invasive breast cancer incidence in Ireland: A population-based study","authors":"Jessica O’Driscoll ,&nbsp;Paula A. Tierney ,&nbsp;Joe McDevitt ,&nbsp;Aline Brennan ,&nbsp;Maria Theresa Redaniel ,&nbsp;Mengyang Zhang ,&nbsp;Kathleen Bennett ,&nbsp;Deirdre Murray ,&nbsp;Maeve Mullooly","doi":"10.1016/j.canep.2025.102864","DOIUrl":"10.1016/j.canep.2025.102864","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the COVID-19 impact on invasive breast cancer incidence and one-year survival in Ireland.</div></div><div><h3>Methods</h3><div>Anonymised aggregate population data from the National Cancer Registry Ireland were used to examine incidence between 2014 and 2020 and differences in the distribution of clinical characteristics using chi-squared tests. Negative binomial regression examined the association between incidence and year of diagnosis. One-year survival was examined by year of diagnosis using Cox proportional hazards regression modelling.</div></div><div><h3>Results</h3><div>For 2020, the age-standardised incidence rate (ASR, per 100,000 females) was 131.9, compared to 163.9 for 2019. In 2020, the incidence rate significantly declined (IRR = 0.41, 95 % CI = 0.22, 0.75) relative to 2019. Fewer cases presented through organised screening (-62.3 %), while similar or increased numbers presented with symptoms (0.1 %) and via other methods (9.0 %) respectively in 2020, compared to 2019. Significant differences were observed in case distribution by ER status (p = 0.02) and stage (p &lt; 0.01) between 2019 and 2020. One-year survival was similar for cases diagnosed during 2014–2019 and in 2020 (HR = 1.07, 95 % CI = 0.89, 1.27).</div></div><div><h3>Conclusions</h3><div>These findings demonstrate reductions in invasive breast cancer incidence and no difference in one-year survival following the pandemic onset. Additional studies to determine the longer-term COVID-19 impact are needed.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102864"},"PeriodicalIF":2.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response relationship between aspirin and gastric cancer risk: A systematic review and meta-analysis","authors":"Shan Zhang ,&nbsp;Hongwei Wang ,&nbsp;Jingjing Ji ,&nbsp;Ruiyu Chai ,&nbsp;Shiyi Song ,&nbsp;Jikang Shi ,&nbsp;Siyu Liu","doi":"10.1016/j.canep.2025.102873","DOIUrl":"10.1016/j.canep.2025.102873","url":null,"abstract":"<div><div>Gastric cancer (GC) continues to be a significant global health burden, ranking as the fifth most prevalent malignancy and the fourth leading cause of cancer-related mortality worldwide. Emerging evidence suggests that aspirin, a well-known cyclooxygenase (COX) inhibitor, may play a role in reducing the risk of gastric cancer. However, the dose-response relationship between aspirin use and gastric cancer risk remains unclear. This systematic review and meta-analysis aimed to elucidate this relationship by analyzing data from cohort studies published between January 1, 2014, and January 1, 2024. A comprehensive search of PubMed, Embase, and Web of Science yielded six eligible studies involving over 1.5 million participants. The results demonstrated a significant inverse association between aspirin dose and gastric cancer risk, with a relative risk (RR) of 0.73 (95 % CI: 0.57–0.94) for the highest versus lowest aspirin dose. Dose-response analysis revealed a nonlinear relationship, suggesting that higher doses of aspirin were associated with a greater reduction in gastric cancer risk. Subgroup analyses suggested regional variations in the protective effect of aspirin, with stronger associations observed in Asian populations. Our results provide strong evidence of the association between dose of aspirin use and risk of gastric cancer. These findings highlight the potential role of aspirin in gastric cancer chemoprevention and offer valuable insights for future research and clinical applications.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102873"},"PeriodicalIF":2.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of occupational and recreational solar ultraviolet radiation with the risk of prostate cancer: A Canadian cohort study","authors":"Momtafin Khan ,&nbsp;Will D. King ,&nbsp;Darren R. Brenner ,&nbsp;Cheryl E. Peters ,&nbsp;Dylan E. O’Sullivan","doi":"10.1016/j.canep.2025.102872","DOIUrl":"10.1016/j.canep.2025.102872","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study was to examine the relationship of recreational and occupational exposure to solar ultraviolet radiation (UVR) with the risk of developing prostate cancer (PC).</div></div><div><h3>Methods</h3><div>Data from three provincial prospective cohorts in Canada (Ontario Health Study, Québec’s CARTaGENE, and Alberta’s Tomorrow Project) were used. A nested case-cohort approach was applied for the examination of occupational solar UVR and was based on longest held job at baseline. Cox proportional hazards models with age as the time-scale were used to estimate the risk of PC associated with self-reported time spent in the sun and occupational solar UVR (weighted model). Effect modification by body mass index (BMI) was explored.</div></div><div><h3>Results</h3><div>A total of 543 PC cases were included in the analysis of time spent in the sun and 1667 PC cases were included in the analysis of occupational solar UVR. Compared to &lt; 1 h/day in the sun, 1-&lt; 2 h (Hazard Ratio [HR] 0.96, 95 % CI: 0.81–1.13) and ≥ 2 h (HR 0.89, 95 % CI: 0.76–1.05) were not significantly associated with PC risk. Occupational solar UVR was also not significantly associated with PC risk (HR 1.08, 95 % CI: 0.90–1.30). Compared to &lt; 1 h/day, individuals who spent 1-&lt; 2 h in the sun were at a reduced risk of PC if they had a normal BMI (HR 0.64, 95 % CI: 0.44–0.92), but not if they were overweight (HR 0.99, 95 % CI: 0.76–1.30) or obese (HR 1.20, 95 % CI: 0.90–1.61).</div></div><div><h3>Conclusion</h3><div>Overall, results do not support an association between solar UVR exposure and PC risk, but larger studies are needed to confirm these findings. There is some indication of effect modification by BMI that should be explored in future studies.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102872"},"PeriodicalIF":2.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between sleep-related factors and bladder cancer: A cross-sectional study in the UK Biobank","authors":"Yiming Chen ,&nbsp;Enyu Tong ,&nbsp;Yufeng Rao ,&nbsp;Evan YW Yu ,&nbsp;Yating Chen ,&nbsp;Maurice Zeegers ,&nbsp;Anke Wesselius","doi":"10.1016/j.canep.2025.102871","DOIUrl":"10.1016/j.canep.2025.102871","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to explore the associations between various sleep-related factors and bladder cancer risk. These factors included sleep duration, ease of getting up in the morning, daytime napping, insomnia, snoring, daytime dozing, and chronotype.</div></div><div><h3>Methods</h3><div>This study is cross-sectional, and the data were obtained from UK Biobank. A total of 502,492 participants at recruitment (2006–2010) were included. Multiple imputation was performed to address missing data. Univariable logistic regression models adjusted for covariates were used to examine associations between sleep-related factors and bladder cancer, and if there were factors associated with bladder cancer, a multivariable logistic regression would be conducted to evaluate potential mutual confounding between these factors. A stratified analysis was conducted to assess if the associations would be applicable for both genders. A <em>P</em>-value below 0.05 was considered to indicate statistical significance.</div></div><div><h3>Results</h3><div>There were 1414 (0.28 %) participants had been diagnosed with bladder cancer at recruitment. After adjusting for all covariables, daytime napping and insomnia with a frequency of “usually” were associated with a higher prevalence of bladder cancer. The multivariable logistic regression suggested that daytime napping and insomnia remained independently associated with bladder cancer and there was no significant evidence of confounding effects. Stratified analyses indicated a potential trend suggesting that frequent daytime napping or insomnia may be associated with an increased risk of bladder cancer in both genders.</div></div><div><h3>Conclusion</h3><div>Daytime napping and insomnia are associated with an increased risk of bladder cancer. Future research is needed to explore the underlying mechanisms and establish causative relationships.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102871"},"PeriodicalIF":2.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right versus left lung cancer: Findings from the Japanese cancer registry database","authors":"Nobuaki Michihata ,&nbsp;Aya Washio ,&nbsp;Yoshihide Terada ,&nbsp;Naoto Kaneko ,&nbsp;Yohko Nakamura ,&nbsp;Yoshitaka Hippo","doi":"10.1016/j.canep.2025.102870","DOIUrl":"10.1016/j.canep.2025.102870","url":null,"abstract":"<div><div>Laterality, which is the biological difference between the left and right sides of the body, has been identified as a potential factor in cancer development and progression. Previous studies have suggested that lung cancer incidence may differ between the right and left lungs, influenced by anatomical, genetic, and environmental factors. In this study, we investigated the relationship among lung cancer laterality, incidence, and prognosis. This cohort study used data from the Chiba Prefecture Cancer Registry (2013–2020) and included 36,502 patients with primary lung cancer. Patient characteristics were compared between patients with right- and left-sided lung cancers. Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards models were used to assess laterality differences in mortality, adjusted for age, sex, summary stage, histological type, and other covariates. Right-sided lung cancer was more prevalent (60 %) than left-sided (40 %). The Cox model revealed a slightly higher mortality rate for right-sided lung cancer than for left-sided cancer (hazard ratio [HR]: 1.05, 95 % confidence interval [CI]: 1.02–1.08, <em>p</em> = 0.003). Sex-stratified analysis showed a higher mortality risk for male with right-sided cancer (HR: 1.08, 95 % CI: 1.04–1.12, <em>p</em> &lt; 0.001) but no significant laterality difference in female. The higher prevalence of right-sided lung cancer may be due to anatomical differences and genetic factors, such as the higher prevalence of the L858R mutation. Although the clinical impact of laterality differences is minimal, these findings provide insights into lung cancer pathogenesis and may contribute to advancing personalized medicine.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102870"},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}