Cancer Epidemiology最新文献

{"title":"Bridging data gaps: Methodological advances in extracting and analyzing genetic information from unstructured clinical records in hereditary cancer","authors":"Danny Styvens Cardona ,&nbsp;Juan Pablo Valencia-Arango ,&nbsp;Juan Pablo Gallo ,&nbsp;Catalina Andrea Bustamante ,&nbsp;Richard Orlando Salazar ,&nbsp;Carlos Andrés Carmona ,&nbsp;Melisa Naranjo Vanegas ,&nbsp;Carolina Jaramillo Jaramillo ,&nbsp;Juliana Espinosa Moncada ,&nbsp;Harvy Mauricio Velasco ,&nbsp;Natalia Gallego Lopera","doi":"10.1016/j.canep.2025.102940","DOIUrl":"10.1016/j.canep.2025.102940","url":null,"abstract":"<div><h3>Introduction</h3><div>The global impact of cancer, driven by both acquired and hereditary mutations, underscores the necessity for extensive research efforts. Despite the increasing volume of genetic data, significant gaps remain in data science research, particularly in Latinos and admixed populations. This study utilizes advanced data science techniques to integrate genetic and clinical data, aiming to improve the understanding of hereditary cancer in Colombia and demonstrating the transformative potential of data-driven approaches in cancer research.</div></div><div><h3>Methods</h3><div>This observational study analyzed healthcare databases from four regions and 11 cities in Colombia. Genetic data were extracted from PDF reports within SURA Colombia's Electronic Health Records (a Latin American health insurance provider) for individuals referred for hereditary cancer testing between October 2019 and November 2021. Variants in 30 genes, aligned with NCCN guidelines, were examined using Next-Generation Sequencing (NGS). Data extraction was automated using Python and R, followed by integration and analysis of genetic, clinical, and sociodemographic data using advanced data science tools hosted on Azure infrastructure. These tools enabled predictive modeling and cross-referencing to explore correlations between genetic variants and clinical outcomes.</div></div><div><h3>Results</h3><div>The study included 1377 patients, with a predominance of women (92.81 %) and 63 % from the northwestern region of Colombia. The largest age group (40.37 %) was between 31 and 44 years, and 95.35 % had a personal cancer history, primarily breast cancer (75.86 %). Hereditary cancer testing revealed 145 positive results and 587 uncertain outcomes. Data science-driven analysis identified higher positivity rates in patients aged 31–44 and over 50, particularly in the northeast and central regions. Among positive results, 42.6 % included variants of uncertain significance, with 95.9 % of these patients having a personal cancer history.</div></div><div><h3>Conclusion</h3><div>This study highlights the significant role of data science in analyzing hereditary cancer data. Advanced computational techniques can aid in genetic variant reclassification, uncover patterns in underrepresented populations, and inform personalized interventions for hereditary cancer management in Latin America.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102940"},"PeriodicalIF":2.3,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational heat exposure and stomach cancer risk in a pooled analysis of two Spanish case-control studies in the stomach cancer pooling project – StoP consortium","authors":"Alice Hinchliffe ,&nbsp;Miquel Vallbona-Vistós ,&nbsp;Juan Alguacil ,&nbsp;Manolis Kogevinas ,&nbsp;Sanni Uuksulainen ,&nbsp;Nuria Aragonés ,&nbsp;Adonina Tardón ,&nbsp;Jesus Vioque ,&nbsp;Mary H. Ward ,&nbsp;Charles S. Rabkin ,&nbsp;M. Constanza Camargo ,&nbsp;Claudio Pelucchi ,&nbsp;Carlo La Vecchia ,&nbsp;Paolo Boffetta ,&nbsp;Michelle C. Turner","doi":"10.1016/j.canep.2025.102938","DOIUrl":"10.1016/j.canep.2025.102938","url":null,"abstract":"<div><h3>Background</h3><div>Occupational heat stress occurs frequently and is increasing with climate change. Studies of occupational heat exposure and stomach cancer risk are limited. We used data from the international Stomach cancer Pooling (StoP) Project to investigate the relationship between occupational heat exposure and stomach cancer risk in a pooled analysis of two Spanish case-control studies, including 566 stomach cancer cases and 2984 controls.</div></div><div><h3>Methods</h3><div>The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to participant occupations. We evaluated three exposure indices: ever vs. never exposed, cumulative exposure and duration (years). We calculated odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) using unconditional logistic regression models including terms for potential confounders.</div></div><div><h3>Results</h3><div>Overall, 60.6 % of cases and 42.7 % of controls were ever occupationally exposed to heat. Occupational heat exposure was associated with a moderately elevated risk of stomach cancer (OR 1.31; 95 % CI 1.05, 1.63) when comparing ever vs. never exposed individuals in both studies combined. Elevated ORs were also observed across categories of cumulative exposure and duration (p-trend = 0.01 and 0.03, respectively). Findings were robust to additional covariate adjustment and in analysis of never smokers. There was no clear evidence for interaction according to exposure status to other suspected occupational stomach carcinogens.</div></div><div><h3>Conclusion</h3><div>Findings from this study provide some evidence for a positive association between occupational heat exposure and stomach cancer risk. Further research is needed to advance occupational heat assessment tools for epidemiological research as well as studies in more geographically diverse populations.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102938"},"PeriodicalIF":2.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium intake and gastric cancer risk: A systematic review and dose–response meta-analysis of observational studies","authors":"Alex Richard Costa Silva ,&nbsp;Marcela de Araújo Fagundes ,&nbsp;Valdete Regina Guandalini ,&nbsp;Maria Paula Curado","doi":"10.1016/j.canep.2025.102939","DOIUrl":"10.1016/j.canep.2025.102939","url":null,"abstract":"<div><div>Calcium has been proposed as a protective factor against certain types of cancer, but findings related to gastric cancer (GC) are inconsistent. This meta-analysis aimed to assess the association between calcium intake and the risk of GC. A comprehensive search was conducted in PubMed, Scopus, EMBASE, LILACS, and Web of Science for cohort and case-control studies published up to August 19, 2024. The quality of the studies was assessed using the Newcastle–Ottawa Scale. Publication bias was tested using Egger’s and Begg’s tests. Relative risks (RRs) and 95 % confidence intervals (CIs) were pooled through a random-effects model. Given the substantial heterogeneity and potential variation in intake levels across populations, a dose-response analysis was conducted to explore potential trends across the full range of calcium consumption. Thirteen studies involving 1,610,992 participants met the inclusion criteria. A non-significant inverse association was observed between total calcium intake and GC risk when comparing the highest vs lowest intake categories (RR: 0.85; 95 % CI: 0.70–1.05). While this categorical comparison was not statistically significant, the dose-response analysis revealed a significant linear protective effect, with a 10 % reduction in risk per 300 mg/day increase in dietary calcium intake (RR: 0.90; 95 % CI: 0.82–0.99). To account for potential variations across intake levels, a non-linear model was also applied, indicating a clearer risk reduction above 400 mg/day (p for non-linearity &lt; 0.001). Overall, this dose-response meta-analysis suggests that higher dietary calcium intake may have a protective effect against GC, reinforcing the importance of considering calcium in dietary strategies for GC prevention, although more studies are needed to confirm these findings.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102939"},"PeriodicalIF":2.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of using general and cancer-specific health administrative data to identify treatment exposures in adolescents and young adults with cancer: A population-based study using the IMPACT cohort.","authors":"Louise Guolla, Cindy Lau, Kelvin K W Chan, Paul C Nathan, Sumit Gupta","doi":"10.1016/j.canep.2025.102902","DOIUrl":"10.1016/j.canep.2025.102902","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer treatment details (i.e., radiation site, chemotherapy dose) are required to conduct rigorous health services research but are difficult to obtain from administrative data. We conducted a validation study to ascertain the optimal algorithm for defining cancer treatment details in cancer-specific and general health administrative data using available chart-abstracted data from adolescent and young adult (AYA) cancer patients.</p><p><strong>Methods: </strong>Health administrative data and cancer treatment data reported by visit in Ontario, Canada were compared separately and in a combined algorithm to a reference-standard chart-abstracted database of AYA cancer patients diagnosed in 2005-2012 (n = 1173). We tested algorithms for three tiers of treatment details: any chemotherapy/radiotherapy provided; type of chemotherapy/site of radiation; dose of chemotherapy/radiation. For each algorithm, we calculated sensitivity, specificity, positive predictive value, negative predictive value with 95 % confidence intervals (95 %CI) and simple kappa statistics, overall and according to cancer type, diagnosis period, and locus of care.</p><p><strong>Results: </strong>General health administrative data had high sensitivity and specificity (> 80 %) for detection of any chemotherapy (n = 942) or radiation exposure (n = 412) and was not improved by using cancer-specific data. In 475 patients (40.5 %) with chemotherapy treatment records, sensitivity (22.4-59.6 %) and specificity (95.8-99.1 %) varied by chemotherapy type/class. Factors associated with missing records include locus of care (9.5 % in pediatric vs. 81.7 % in adult cancer centres), year of diagnosis, and type of cancer. There was moderate to strong correlation (r = 0.50-0.79) between dosing for the most common anthracyclines, combined alkylators, cisplatin, and bleomycin. For radiation treatment data (n = 406, 98.5 %), sensitivity and specificity for radiation site ranged from 73.4 % to 91.2 % and 96.6 % to 99.7 %, respectively, with strong dosing correlation (r = 0.63-0.95, by site).</p><p><strong>Conclusions: </strong>Both general and cancer-specific health administrative data have value in determining receipt of chemotherapy and/or radiation and can be used reliably to create cohorts of exposed cancer patients. More granular information regarding dose and type of chemotherapy and dose and site of radiation therapy is highly specific but limited by variable sensitivity. Care should be taken when using the data to estimate prevalence, compare treated/untreated groups or when full capture of an exposed population is otherwise required as underestimations of the true effect may occur.</p>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"102902"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends, future projections, and epidemiological associations of Mesothelioma: A comprehensive analysis from 1980 to 2050.","authors":"Shanjie Luan, Yanqing Wang","doi":"10.1016/j.canep.2025.102900","DOIUrl":"10.1016/j.canep.2025.102900","url":null,"abstract":"<p><strong>Background: </strong>Malignant mesothelioma is a rare but aggressive cancer primarily caused by occupational asbestos exposure. This study aims to comprehensively assess global mesothelioma incidence and mortality trends, examine their associations with the Human Development Index (HDI), project future burden through 2050, and investigate epidemiological correlations with other malignancies.</p><p><strong>Methods: </strong>We extracted mesothelioma incidence and mortality data from GBD 2021 and GLOBOCAN 2022, covering 204 and 185 countries from 1980 to 2022, respectively. Temporal trends were analyzed using estimated annual percentage change (EAPC), while age-period-cohort (APC) modeling was applied in six high-HDI countries to assess generational burden shifts. Future projections were generated using age-stratified machine-learning models trained on historical data and validated against multiple forecasting methods. Additionally, mesothelioma's epidemiological associations with 27 other cancers were analyzed using linear and logistic regression.</p><p><strong>Results: </strong>Between 1990 and 2021, global mesothelioma incidence and mortality showed a modest decline (ASIR EAPC: -0.2 [95 % UI: -0.32 to -0.08]; ASDR EAPC: -0.23 [95 % UI: -0.3 to -0.16]). Males exhibited a significantly higher burden than females, with the UK and Australia reporting the highest incidence and mortality rates. A clear threshold effect of HDI was observed, with mesothelioma rates remaining stable below HDI 0.8 but rising sharply beyond this level. Additionally, mesothelioma demonstrated strong positive correlations with tracheobronchial lung cancer, ovarian cancer, and Hodgkin lymphoma, suggesting potential shared environmental and occupational risk factors.</p><p><strong>Conclusions: </strong>Our findings provide the most up-to-date epidemiological insights into mesothelioma, highlighting its stable long-term burden, gender disparities, and socioeconomic influences.</p>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"98 ","pages":"102900"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to ‘reverse causality’ comment","authors":"Shan Zhang ,&nbsp;Hongwei Wang ,&nbsp;Jingjing Ji,&nbsp;Ruiyu Chai,&nbsp;Shiyi Song,&nbsp;Jikang Shi,&nbsp;Siyu Liu","doi":"10.1016/j.canep.2025.102928","DOIUrl":"10.1016/j.canep.2025.102928","url":null,"abstract":"<div><div>This document is the authors' response to the received comments for manuscript CANEP-D-25–00912.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102928"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10 Years of breast cancer treatment trends in Fars Province, report of Shiraz Breast Cancer Registry","authors":"Majid Akrami ,&nbsp;Amirhesam Moosazadeh ,&nbsp;Mehrdad Taghva ,&nbsp;Nastaran Tavakolian ,&nbsp;Marzieh Karami Rad ,&nbsp;Zahra Keumarsi ,&nbsp;Masoumeh Ghoddusi Johari ,&nbsp;Vahid Zangouri","doi":"10.1016/j.canep.2025.102937","DOIUrl":"10.1016/j.canep.2025.102937","url":null,"abstract":"<div><h3>Background</h3><div>Despite global recommendations favoring breast-conserving surgery (BCS) with radiotherapy for early-stage breast cancer, there is limited long-term evidence on surgical trends and survival outcomes in low- and middle-income countries such as Iran. Understanding these patterns is crucial to improving treatment equity and patient outcomes. This study aimed to evaluate two-decade trends in surgical approach selection for breast cancer and to compare survival outcomes between BCS and mastectomy in Fars province, Iran.</div></div><div><h3>Methods</h3><div>Data from 10,091 women diagnosed with breast cancer between 2000 and 2022 were extracted from the Shiraz Breast Cancer Registry. Patients were categorized into four groups based on type of surgery (BCS or mastectomy) and receipt of radiotherapy. Logistic regression was used to identify factors influencing treatment selection. Survival and recurrence were analyzed using Kaplan-Meier and factors affecting survival were evaluated using the Cox regression model.</div></div><div><h3>Results</h3><div>Between 2000 and 2022, the proportion of patients undergoing BCS plus radiotherapy increased from 30.5 % to 73.8 %, surpassing mastectomy. The BCS plus radiotherapy group showed the most favorable outcomes, with the lowest breast cancer-specific mortality (6.2 %), recurrence rate (10.2 %), and the highest 10-year BCSS (96.01 %). These associations remained significant after multivariable adjustment.</div></div><div><h3>Conclusion</h3><div>This study reveals a significant shift toward BCS plus radiotherapy in southern Iran over the past two decades. BCS with radiotherapy is associated with superior survival outcomes compared to mastectomy. However, access barriers continue to prevent many women from receiving the optimal surgical approach, indicating the need for policy and health system interventions.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102937"},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden and international trends of laryngeal cancer incidence: A population-based study of recorded data and national estimates","authors":"Amanda Ramos da Cunha ,&nbsp;Harriet Rumgay ,&nbsp;Jerome Vignat ,&nbsp;Mathieu Laversanne ,&nbsp;Murielle Colombet ,&nbsp;Maria Paula Curado ,&nbsp;Gail Garvey ,&nbsp;Sarbani Ghosh-Laskar ,&nbsp;Brian O’Sullivan ,&nbsp;Shama Virani ,&nbsp;Isabelle Soerjomataram ,&nbsp;Marion Piñeros","doi":"10.1016/j.canep.2025.102935","DOIUrl":"10.1016/j.canep.2025.102935","url":null,"abstract":"<div><div>Laryngeal cancer shows considerable variation in global incidence, which has primarily been studied through national estimates. This study aims to analyse the global incidence of laryngeal cancer, comparing estimated and high-quality recorded data, and examine temporal trends to inform targeted prevention strategies. Estimated incidence rates for 2022 were obtained from the GLOBOCAN 2022 database for 185 countries. Recorded incidence data from population-based cancer registries (PBCRs) for the five-years period 2013–2017 were sourced from Cancer Incidence in Five Continents (CI5-XII). Temporal trends and the Estimated Annual Percent Change were assessed for 34 countries using the Global Cancer Observatory – Cancer Over Time database. The highest estimated age-standardized incidence rates (ASIRs) were observed in Cuba, Moldova, and Romania, particularly among males: 14.8, 12.2, and 10.3 per 100,000, respectively. Recorded data showed significant regional variability, with the highest ASIRs for males in Pskov, Russia (13.3 per 100,000) and the Azores, Portugal (11.8 per 100,000). Most countries exhibited a decline in laryngeal cancer rates among males, while trends among females remained largely stable. Our findings underscore the importance of PBCRs in identifying high-risk populations for developing laryngeal cancer. While national estimates are essential for understanding the global distribution of laryngeal cancer and other malignancies, they may overlook subnational variations. Expanding the coverage and quality of PBCRs is crucial for improving cancer surveillance and enhancing prevention and control efforts at national and global level.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102935"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in locoregional treatment of programme-detected ductal carcinoma in situ in New Zealand women, 1999–2022","authors":"Qian Chen ,&nbsp;Ian Campbell ,&nbsp;Mark Elwood ,&nbsp;Alana Cavadino ,&nbsp;Phyu Sin Aye ,&nbsp;Sandar Tin Tin","doi":"10.1016/j.canep.2025.102934","DOIUrl":"10.1016/j.canep.2025.102934","url":null,"abstract":"<div><h3>Purpose</h3><div>Ethnic and socioeconomic disparities exist in treatment of invasive breast cancer in New Zealand. This study investigated trends and disparities in locoregional treatment of ductal carcinoma in situ (DCIS) detected by BreastScreen Aotearoa (BSA), the national breast screening programme.</div></div><div><h3>Methods</h3><div>Women with programme-detected DCIS from 1999 to 2022 were identified from BSA records linked to the national cancer registry and hospital discharge records. Logistic regression identified associated factors.</div></div><div><h3>Results</h3><div>Of the 6087 cases identified, 39.7 % received breast-conserving surgery (BCS) with radiotherapy (RT), 31.5 % had mastectomy and 28.8 % had BCS alone. BCS with RT increased from 27.6 % in 1999 to 41.1 % in 2006, followed by a modest increase to 46.7 % in 2022, while mastectomy decreased from 33.3 % in 1999 to 25.4 % in 2022. The post-BCS RT use was less common among Pacific women. Sentinel lymph node biopsy (SLNB) increased from 6.2 % in 2004 (when it was implemented nationwide) to 26.0 % in 2007, then reached 37.1 % in 2013, before declining to 24.5 % in 2022. Pacific and Asian women who had mastectomy were more likely to have SLNB. Immediate breast reconstruction (IBR) after a mastectomy increased from 11.4 % in 1999 to 39.8 % in 2009, then underwent a modest decline to 22.7 % in 2022. Māori, older women, and those living in the deprived or rural areas were less likely to receive IBR.</div></div><div><h3>Conclusion</h3><div>Locoregional treatment for programme-detected DCIS has improved over time; however, ethnic and socioeconomic disparities persist, underscoring the need to improve equity of cancer care in New Zealand.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102934"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic, health-related and geographical risk factors for locally advanced keratinocyte carcinoma: A nationwide population-based study in Denmark","authors":"Anne Sofie Krogh Holdam ,&nbsp;Hans B. Rahr ,&nbsp;Erik Frostberg ,&nbsp;Karina Rønlund ,&nbsp;Vibeke Koudahl","doi":"10.1016/j.canep.2025.102936","DOIUrl":"10.1016/j.canep.2025.102936","url":null,"abstract":"<div><h3>Background</h3><div>Most keratinocyte carcinomas (KC) are localized and slow-growing. However, for some patients, KC can become locally advanced lesions and cause substantial tissue damage that require extensive surgery to manage. We wanted to explore risk factors for locally advanced disease with the overall aim to offer more timely diagnosis and treatment.</div></div><div><h3>Methods</h3><div>This nationwide, register-based cohort study examined the association of demographic factors, educational level, disposable income, cohabitating status, comorbidity, and region of residence with tumor (T) category for patients with a first-time diagnosis of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) from 2007 to 2021, using multivariable logistic regression analyses.</div></div><div><h3>Results</h3><div>We identified 166,467 BCC and 36,609 SCC patients. Male sex, old age, lower educational level and disposable income, living alone, and comorbidity were linked to higher odds of developing a ≥T2 tumor. Residence outside the Capital Region increased the risk of locally advanced BCC, while the risk of locally advanced SCC was higher in the Zealand, Central, and Northern regions.</div></div><div><h3>Conclusion</h3><div>There are significant associations between socioeconomic status, comorbidity, and region of residence and the risk of developing ≥T2 tumors in both BCC and SCC. Efforts to enhance early detection and treatment should focus on vulnerable individuals.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"99 ","pages":"Article 102936"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}