Cancer Epidemiology最新文献

{"title":"Life years lost by childhood cancer treatment and health related late effects among childhood cancer survivors","authors":"Thibaud Charrier ,&nbsp;Nadia Haddy ,&nbsp;Brice Fresneau ,&nbsp;Boris Schwartz ,&nbsp;Neige Journy ,&nbsp;Charlotte Demoor-Goldschmidt ,&nbsp;Ibrahima Diallo ,&nbsp;Isabelle Aerts ,&nbsp;François Doz ,&nbsp;Vincent Souchard ,&nbsp;Giao Vu-Bezin ,&nbsp;Anne Laprie ,&nbsp;Sarah Lemler ,&nbsp;Véronique Letort ,&nbsp;Carole Rubino ,&nbsp;Kaniav Kamary ,&nbsp;Naïla Myriam Aba ,&nbsp;Claire Ducos ,&nbsp;Médéa Locquet ,&nbsp;Florent de Vathaire ,&nbsp;Aurélien Latouche","doi":"10.1016/j.canep.2024.102692","DOIUrl":"10.1016/j.canep.2024.102692","url":null,"abstract":"<div><h3>Background</h3><div>Identifying risk factors contributing the most to mortality of childhood cancer survivors is essential to guide harm reduction efforts in childhood cancer treatments, and long-term follow-up of childhood cancer survivors.</div></div><div><h3>Methods</h3><div>We assessed Life Years Lost from childhood cancer treatments and their health-related late effects among the French Childhood Cancer Survivors Study, a cohort of 7670 5-year childhood cancer survivors. Using a landmark strategy, we also assessed time-varying effects of risk factors, and how the multi-morbidity affects life years lost.</div></div><div><h3>Results</h3><div>We found subsequent malignant neoplasm (9.0 years [95 %CI: 4.3–13.7]), severe cardiac disease (8.0 years [95 %CI: 1.2–14.9]), and the use of radiotherapy (6.0 years [95 %CI: 4.7–7.3]) to be the highest contributors to Life Years Lost among childhood cancer survivors. We found no interaction impact on life years lost between health related late effects considered.</div></div><div><h3>Conclusions</h3><div>Those findings suggest that radiotherapy is the root cause of early mortality among childhood cancer survivors. Moreover patients experiencing a subsequent malignant neoplasm or a cardiac disease should be monitored closely after the event, as comorbidity is common and causes premature deaths.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102692"},"PeriodicalIF":2.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenge of ovarian cancer care in the oldest old.","authors":"Jérémy Barben, Angéline Galvin, Ariane Mamguem Kamga, Nicolas Bertrand, Julie Niogret, Julie Tisserand, Valérie Quipourt, Leila Bengrine-Lefevre, Tienhan Sandrine Dabakuyo-Yonli","doi":"10.1016/j.canep.2024.102697","DOIUrl":"https://doi.org/10.1016/j.canep.2024.102697","url":null,"abstract":"<p><strong>Introduction: </strong>Ovarian cancer (OC) is the eighth most common cancer in women, with a poor prognosis, particularly in older women. The aim of this study was to describe an octogenarian population with OC and to examine the differences in net survival (NS) according to age.</p><p><strong>Material and methods: </strong>In this retrospective observational population-based study from a gynecological cancer registry, patients aged > 18 years with an identified epithelial ovarian cancer stage IA to IVB diagnosed between 1998 and 2018 were included. Patients with non-available FIGO stage were excluded. Patients were stratified into three age groups: <70, 70-79 and ≥80 years, then by OC stage (FIGO I-II, IIIA-IIIB, IIIC-IV). Sociodemographic and cancer-related variables were compared using univariate test (Khi²). The 5-year NS was calculated using the Pohar-Perme method.</p><p><strong>Results: </strong>Among the 721 patients included: 462 (64.1 %) were younger than 70 years, 176 (24.4 %) were aged between 70 and 79 years, and 83 (11.85 %) were aged 80 years or older. Patients ≥80 years had a trend for lower rate of serous carcinoma than the other age subgroups. As age increased, patients were less likely to undergo surgery and chemotherapy. While 73 % of women <70 years received a combination of surgery and chemotherapy, the rate was 62 % among women 70-79 years and 27 % among women ≥80 years (p<.0001). When focusing on FIGO IIIC-IV stages, the 5-year NS rate for women <70 years was 45.1 % (95 % CI 39.1-52.0). For women 70-79 years, it was 25.9 % (95 % CI 18.6-36.1), and for those ≥80 years, it was 19.5 % (95 % CI 10.0-38.0) (p<.005).</p><p><strong>Discussion: </strong>The oldest patients had less optimal treatment and a lower NS compared to patients in their seventies or younger. Frailty should be carefully assessed to optimize care in the oldest patients with OC.</p>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":" ","pages":"102697"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New South Wales data linkage study reveals a shift in HCC mortality risk: Time for broader strategies","authors":"Salim Maher ,&nbsp;Alamgir Kabir ,&nbsp;Jason Behary ,&nbsp;Damian P. Conway ,&nbsp;Anna C. Akon ,&nbsp;Margo Barr ,&nbsp;Amany Zekry","doi":"10.1016/j.canep.2024.102690","DOIUrl":"10.1016/j.canep.2024.102690","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to examine the impact of sociodemographic and clinical factors on hepatocellular carcinoma (HCC) mortality in New South Wales (NSW), Australia.</div></div><div><h3>Methods</h3><div>We conducted a 15-year retrospective study (2001–2015) using data linkage of health records and cancer registry databases, to identify all HCC cases and analyse HCC-related and all-cause mortality rates. Location-based socioeconomic status (SES) was determined using the Socioeconomic Indexes for Areas (SEIFA). Multivariable Cox regression analysis was used to determine the effect of key variables on mortality.</div></div><div><h3>Results</h3><div>5564 cases of HCC were diagnosed during the study period. A study cohort of 5454 cases was analysed after excluding cases with key missing data. More than half of the chronic liver disease cases were due to non-viral causes. During the study period, 4033 deaths occurred, of which 2862 were HCC-related. The median survival time for HCC-related deaths was 547 days, and the 5-year survival rate was 31.3 %. Higher HCC-related mortality rates were observed in SEIFA quintiles 2, 3 and 4, when compared to 5 (where SEIFA 1 is most disadvantaged, and SEIFA 5 is most advantaged). Furthermore, significantly increased HCC-related mortality was observed for those aged ≥65, male gender, Australian-born, hospitalisation due to complications of alcohol use, having metastatic HCC at diagnosis, and not receiving surgery for HCC.</div></div><div><h3>Conclusions</h3><div>There is higher prevalence of non-viral-related HCC than viral-related HCC in NSW, Australia, where HCC-related mortality risk is greatest among those Australian-born and lower to higher SES, when compared to highest SES. Identifying factors contributing to these emerging disparities is crucial for developing effective prevention programs and allocating research and health resources.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102690"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical characteristics of hepatocellular carcinoma in Xiamen","authors":"Zhenzhen Zhang ,&nbsp;Meixia Wang ,&nbsp;Yanfang Wu ,&nbsp;Guobin Chen ,&nbsp;Boheng Zhang","doi":"10.1016/j.canep.2024.102691","DOIUrl":"10.1016/j.canep.2024.102691","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the epidemiological characteristics of hepatocellular carcinoma in Xiamen and offer recommendations for its control and prevention. Methods: Data obtained from liver cancer screening in 2016–2018 and 2019–2020 in patients with hepatocellular carcinoma in Xiamen were collected using Xiamen Healthcare Big Data Platform. Epidemiological characteristics were analyzed descriptively by different years. Results: From 2016–2020, there were 3740 patients with hepatocellular carcinoma in Xiamen. In the patients, the percentage of males was higher than that of females (83.13 % vs 16.87 %). From 2019–2020, there was an increase in the detection rates for disorders including hepatitis B, hypertension, diabetes, fatty liver and cirrhosis of the liver, and there was a decrease in the prevalence of hepatitis C. There was an increase in the values of all hematological indicators of infection in patients with liver cancer in 2019–2020 compared with the previous three years. From 2016–2020, there was a year-on-year increase in the prevalence of liver cancer and fatty liver. From 2018–2020, there was an increasing trend in the prevalence of liver cancer in overweight patients in the population with fatty liver. Conclusion: In 2019–2020, there was an increase in the prevalence of chronic diseases in patients with hepatocellular carcinoma. Comprehensive liver cancer screening provides an important guide for the prevention, early diagnosis and treatment of liver cancer and for clinicians to assess patients’ condition.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102691"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A competing-risk nomogram for predicting gastric cancer-specific survival in patients over 70 years: A SEER-based study","authors":"Maorun Zhang ,&nbsp;Xuliang Yang ,&nbsp;Jinyan Jia ,&nbsp;Qi Zhang ,&nbsp;Heyuan Niu ,&nbsp;Tao Yu ,&nbsp;Gang Liu","doi":"10.1016/j.canep.2024.102696","DOIUrl":"10.1016/j.canep.2024.102696","url":null,"abstract":"<div><h3>Background</h3><div>Cancer-specific survival in older patients with gastric cancer is competitively affected by death from other causes. This study aimed to investigate cancer-specific survival and associated risk factors by competing-risk analysis in older patients with gastric cancer.</div></div><div><h3>Methods</h3><div>The data of this study are from the SEER database, using univariable and multivariable analysis of competitive risk model to weaken the impact of competitive events, explore the risk factors of cancer-specific survival, and developed a nomogram model. Then, the performance of the model is verified by C-index, ROC curve, calibration curve and DCA, and the new model is compared with the traditional TNM stage by NRI and IDI.</div></div><div><h3>Results</h3><div>Our study encompassed a total of 8183 patients, with 5731 in the training cohort and 2452 in the validation cohort. Univariable and multivariable analysis showed that age, years of diagnosis, race, site, SEER stage, TNM stage, surgery, radiation or chemotherapy, LNE, tumor grade and size are independent risk factors for cancer-specific survival in older patients with gastric cancer. Based on the risk factors, we developed a diagram model to predict cancer-specific survival. C-index, ROC curve, calibration curve and DCA also show good results. We compared the new model with the traditional TNM stage model, and the NRI and IDI showed the new model has been significantly improved.</div></div><div><h3>Conclusion</h3><div>This study developed a nomogram to predict the cancer-specific survival of older patients with gastric cancer, which can accurately predict the prognosis and contribute to clinical treatment decision-making.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102696"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Metformin's role in lowering colorectal cancer risk among individuals with diabetes from the Southern Community Cohort Study”","authors":"Shih-Wei Lai,&nbsp;Kuan-Fu Liao","doi":"10.1016/j.canep.2024.102694","DOIUrl":"10.1016/j.canep.2024.102694","url":null,"abstract":"","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102694"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of combined GSTM1, GSTT1, and GSTP1 genetic polymorphisms with lung cancer risk in male Iraqi Waterpipe Tobacco (Nargila) smokers","authors":"Bassam K. Kudhair ,&nbsp;Fadak M. Abdulridha ,&nbsp;Ghadeer M. Hussain ,&nbsp;Inam J. Lafta ,&nbsp;Noralhuda N. Alabid","doi":"10.1016/j.canep.2024.102689","DOIUrl":"10.1016/j.canep.2024.102689","url":null,"abstract":"<div><div>Mutations in genes encoding proteins necessary for detoxifying oxidative stress products have been predicted to increase susceptibility to lung cancer (LC). Despite this, the association between waterpipe tobacco smoking (WP), genetic polymorphisms, and LC risk remains poorly understood. This is the first study to explore the relationship between WP tobacco smoking and these genetic factors. Previously, we investigated the association of GSTP1 SNPs (rs1695-A/G and rs1138272-C/T) with LC in Iraqi males who smoke WP. Here, we expanded our analysis to include GSTM1 (active/null) and GSTT1 (active/null) genotypes, both individually and in combination with GSTP1 SNPs. Multiplex PCR and RFLP-PCR assays were utilized to determine the genotypes of 123 cases and 129 controls. No significant association was observed between GSTM1-null or GSTT1-null genotypes and LC risk, either separately or in combination with variant genotypes of GSTP1 (rs1695 \"AG+GG\" and rs1138272 \"CT+TT\"). However, smoking WP and carrying null genotypes elevated the risk five-fold for GSTM1-null (OR 5.17, 95 % CI 2.02–13.24, P&lt;0.001) and three-fold for GSTT1-null (OR 3.08, 95 % CI 1.55–6.13, P=0.001) compared to non-smokers carrying active genotypes. Conversely, genotype distribution analysis based on LC histological types did not indicate an increased risk of LC. Lung cancer is a complex multifactorial disease. WP smoking and GSTs genetic polymorphisms might be associated with an increased risk of developing LC. However, our data did not confirm an association between GST polymorphisms alone and the risk of LC.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102689"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and geographical patterns of common childhood cancers in Iran: Evidence from the National Cancer Registry","authors":"Goljamal Jorjani ,&nbsp;Gholamreza Roshandel ,&nbsp;Mohammad Reza Taherian ,&nbsp;Nargesbeigom Mirbehbahani ,&nbsp;Leila Moaddabshoar ,&nbsp;Ali Ahmadi ,&nbsp;Fereshteh Salavati ,&nbsp;Seyed Saeed Hashemi Nazari ,&nbsp;Mahzad Vahidi ,&nbsp;Koorosh Etemad","doi":"10.1016/j.canep.2024.102685","DOIUrl":"10.1016/j.canep.2024.102685","url":null,"abstract":"<div><h3>Introduction</h3><div>Cancer is projected to become the primary cause of death in the 21st century. Although childhood cancer is relatively rare, it remains a significant contributor to mortality among children. This study examines the geographical distribution of childhood cancer incidence in Iranian provinces using data from the National Cancer Registry between 2014 and 2018.</div></div><div><h3>Materials and methods</h3><div>This registry-based study analyzed data from 14,711 children under 20 diagnosed with common childhood cancers, sourced from the Iranian National Population-based Cancer Registry for the period 2014–2018. The age-standardized incidence rates (ASR) were calculated using direct standardization methods and reported per 1 million person-years. Spatial autocorrelation measures, including global and local indices such as Moran's I and Getis-Ord's G, were employed to identify high-risk and low-risk areas, assess overall spatial dependence, and pinpoint specific clusters and hotspots of incidence rates.</div></div><div><h3>Results</h3><div>ASR for childhood cancer in Iran was 119.56 per 1 million individuals aged 0–19 years. Boys had a higher ASR (129.98) than girls (107.68). Childhood cancer cases increased from 2765 in 2014 to 3354 in 2018, with leukemia as the most common type, followed by brain and nervous system, lymphoma, bone, and connective and soft tissue cancers. Spatial analysis identified high-risk clusters in central Iran (Isfahan, Yazd, Tehran) and low-risk clusters in the northeast (Kermanshah, West and East Azerbaijan, Kurdistan).</div></div><div><h3>Conclusion</h3><div>This study highlights high childhood cancer incidence in Iran, particularly among boys and in central regions, with elevated leukemia rates. These findings call for targeted prevention strategies and further research to address geographic and gender disparities and to improve care programs.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102685"},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in head and neck cancer incidence in Ho Chi Minh City, Vietnam between 1996 and 2015","authors":"Fiona Deutsch ,&nbsp;Ngoc Ha Tran ,&nbsp;Dung X. Pham ,&nbsp;Nguyen Dinh Hien ,&nbsp;V. Nguyen Tuan ,&nbsp;Dayna Sais ,&nbsp;Nham Tran","doi":"10.1016/j.canep.2024.102686","DOIUrl":"10.1016/j.canep.2024.102686","url":null,"abstract":"<div><h3>Introduction</h3><div>This study provides an analysis of head and neck cancer (HNC) cases over a 20-year period in Ho Chi Minh City, Vietnam. It aims to shed light on HNC's characteristics and trends in this highly populated urban region.</div></div><div><h3>Methods</h3><div>The analysis encompasses 8974 HNC cases, emphasising incidence rates, gender distribution, and the prevalence of different subtypes, including oral cavity, nasopharyngeal, oropharyngeal, and laryngeal/pharyngeal cancers. Ho Chi Minh City was chosen due to its extensive cancer reporting systems and its role as a major urban healthcare centre attracting a wide range of patients.</div></div><div><h3>Results</h3><div>The study reveals an increasing incidence of HNC in Ho Chi Minh City, with a notable predominance of male patients (73 %). The breakdown of HNC cases shows oral cavity cancer at 34 %, nasopharyngeal at 33 %, oropharyngeal at 12 %, and laryngeal/pharyngeal at 21 %. Compared to global averages, Vietnamese patients are diagnosed at an earlier age, with a noticeable trend of decreasing mean age of diagnosis over the study period.</div></div><div><h3>Conclusion</h3><div>This comprehensive study provides valuable insights into the HNC landscape in Ho Chi Minh City, revealing a slightly lower overall incidence but an earlier age of diagnosis compared to global trends. These findings suggest the need for region-specific public health initiatives and further research to clarify the epidemiological features of HNC in Vietnam.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102686"},"PeriodicalIF":2.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck cancer mortality trends in Espírito Santo, Brazil","authors":"Jéssica Graça Sant’Anna ,&nbsp;Max Moura de Oliveira ,&nbsp;Priscila Marinho Abreu ,&nbsp;Willene dos Santos Machado Zorzaneli ,&nbsp;Camila Batista Daniel ,&nbsp;José Roberto Vasconcelos Podestá ,&nbsp;Maria Paula Curado ,&nbsp;Sandra Ventorin von Zeidler","doi":"10.1016/j.canep.2024.102687","DOIUrl":"10.1016/j.canep.2024.102687","url":null,"abstract":"<div><h3>Introduction</h3><div>In Brazil, regional disparities in mortality rates are evident. This study analyzes the mortality trends of head and neck squamous cell carcinoma (HNSCC) from 1998 to 2017 in Espírito Santo.</div></div><div><h3>Methods</h3><div>Data on deaths were obtained from the Unified Health System's Department of Informatics (DATASUS), and population statistics were sourced from the Brazilian Institute of Geography and Statistics (IBGE). Annual percentage change (APC) calculations with a 95 % confidence interval were used for standardization from 1998 to 2017. The analysis considered age, geographical healthcare regions, and specific anatomical sites (C00–06; C09–10; C12–13; C32; C14). Mortality rates adjusted for age and sex were computed for spatial distribution, focusing on Espírito Santo municipalities in two periods (1998–2007 and 2008–2017).</div></div><div><h3>Results</h3><div>From 1998–2017, males aged 40–59 showed a rise in age-standardized mortality rate from 48.96 to 58.24/100,000. Espírito Santo experienced an increasing mortality trend in males across the health regions, whilst in females the increase was observed only in the Central region. Oral cavity, oropharynx and larynx subsites showed a mortality increase in males with APC of 1.1 %, 4.7 % and 2.6 %, respectively, while females had a rise only in oral cavity cancer deaths. Spatial analysis revealed higher mortality rates in both sexes during 2008–2017 compared to 1998–2007.</div></div><div><h3>Conclusions</h3><div>Our data highlighted an escalating mortality trend from 1998 to 2017 among men aged 40–80 in oral cavity, oropharynx and larynx, whereas the female population experienced a rise limited to oral cavity cancer mortality. As the only study covering this period in Espírito Santo, it serves as a valuable tool for developing strategies for HNSCC management, considering the socio-economic advancements achieved in recent years.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"93 ","pages":"Article 102687"},"PeriodicalIF":2.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}