Identification of non-virologic risk factors for lymphoma after the first year of kidney transplant in adults: A retrospective analysis

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-05-08 DOI:10.1016/j.canep.2025.102832

Alfonso H. Santos Jr, Amer Belal, Rohan Mehta, Hisham Ibrahim, Muhannad A. Leghrouz, Kawther Alquadan

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引用次数: 0

Abstract

Background

Non-virologic risk factors for lymphoma after the first kidney transplant (KT) year or late-onset post-transplant lymphoma (PTL) have been scarcely studied.

Methods

This secondary study re-analyzed de-identified, non-coded data. Cause-specific Cox regressions analyzed associations between non-virologic risk factors and lymphoma or all-cause mortality among kidney transplant recipients (KTRs) with conditional cancer-free survival one year after KT.

Results

Among 166,256 adult KTRs, factors with the strongest risks for late-onset PTL were recipient age > /= 65 and 50–64 years (HR = 2.38, 95 % CI = 2.25–2.77, HR = 1.77, 95 % CI= 1.58–1.79; respectively) and pretransplant cancer history (HR = 1.46, 95 % CI = 1.21–1.77). Other risk factors for late-onset PTL included alemtuzumab induction, other primary kidney disease, a prior KT, male KTR sex, expanded criteria (ECD) transplant, and acute rejection. Factors associated with a decreased risk of late-onset PTL, albeit with an increased mortality risk, included native diabetic renal disease, pre-transplant dialysis > 2 years, and steroids or proliferation signal inhibitors maintenance immunosuppressant.

Conclusion

Non-virologic risk factors including KTRs advanced age or male sex, prior cancer or KT, alemtuzumab induction, ECD transplant, and acute rejection are associated with PTL beyond the first post-KT year.

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成人肾移植一年后淋巴瘤非病毒学危险因素的鉴定：回顾性分析

研究背景：肾移植后第1年或移植后迟发性淋巴瘤（PTL）的非病毒学危险因素研究很少。方法本二次研究重新分析去识别、非编码数据。病因特异性Cox回归分析了非病毒学危险因素与KT后1年有条件无癌生存的肾移植受者（KTRs）淋巴瘤或全因死亡率之间的关系。结果166256例成人ktr患者中，发生迟发性PTL的高危因素为年龄>； /= 65岁和50-64岁(HR = 2.38, 95 % CI= 2.25-2.77, HR = 1.77, 95 % CI= 1.58-1.79；（HR = 1.46, 95 % CI = 1.21-1.77）。迟发性PTL的其他危险因素包括阿仑单抗诱导、其他原发性肾脏疾病、既往KT、男性KTR性别、扩大标准（ECD）移植和急性排斥反应。与迟发性PTL风险降低相关的因素包括先天性糖尿病肾病、移植前透析（ 2年）和类固醇或增殖信号抑制剂维持免疫抑制剂。结论ktr患者的高龄或男性、既往癌症或KT、阿仑单抗诱导、ECD移植和急性排斥反应等非病毒学危险因素与KT后1年以上PTL相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.