Allergic disease and risk of multiple myeloma: A case-control study

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-05-15 DOI:10.1016/j.canep.2025.102839

Simon Cheah , Adrian J. Lowe , Nina Afshar , Julie K. Bassett , Fiona J. Bruinsma , Wendy Cozen , Simon J. Harrison , John L. Hopper , Harindra Jayasekara , H. Miles Prince , Claire M. Vajdic , Nicole Wong Doo , Graham G. Giles , Shyamali C. Dharmage , Roger L. Milne

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Abstract

Background and aims

Multiple myeloma (MM) is responsible for significant morbidity and mortality, yet our knowledge regarding MM aetiology remains limited. We investigated whether a history of allergic conditions is associated with MM risk.

Methods

Incident cases (n = 782) of MM were recruited via cancer registries in Victoria and NSW. Controls (n = 733) were siblings (n = 436) or spouses (n = 297) of cases. Unconditional logistic regression was used to estimate odds ratios (OR) and 95 % confidence intervals (CI) for associations between self-reported allergic conditions (asthma, eczema, food allergy, hay fever) and MM risk.

Results

Eczema was inversely associated with MM risk (OR = 0.54, 95 %CI = 0.42–0.70), as was a combined history of food allergy and eczema (OR = 0.52, 95 %CI = 0.29–0.93). There was an inverse association between a history of any allergic condition (compared with none) and risk of MM (OR = 0.68, 95 %CI = 0.55–0.84). In the mean-centred dose-risk analysis the OR was 0.87 (95 %CI = 0.73–1.04) per additional allergic condition of interest. No notable associations were identified for food allergy, asthma, or hay fever alone.

Conclusions and future directions

We found that a history of allergic disease, particularly eczema, was associated with reduced MM risk. Further research is recommended to confirm findings and investigate potential mechanisms.

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过敏性疾病与多发性骨髓瘤风险：一项病例对照研究

背景和目的多发性骨髓瘤（MM）的发病率和死亡率很高，但我们对其病因的了解仍然有限。我们调查了过敏史是否与MM风险相关。方法通过维多利亚州和新南威尔士州的癌症登记处招募MM病例（n = 782）。对照（n = 733）为病例的兄弟姐妹（n = 436）或配偶（n = 297）。使用无条件逻辑回归来估计自我报告的过敏状况（哮喘、湿疹、食物过敏、花粉热）与MM风险之间的比值比（OR）和95% %置信区间（CI）。结果湿疹与MM风险呈负相关（OR = 0.54, 95 %CI = 0.42-0.70），食物过敏和湿疹合并史与MM风险呈负相关（OR = 0.52, 95 %CI = 0.29-0.93）。任何过敏史（与无过敏史相比）与MM风险呈负相关（OR = 0.68, 95 %CI = 0.55-0.84）。在以平均为中心的剂量风险分析中，每增加一个感兴趣的过敏状况，OR为0.87（95 %CI = 0.73-1.04）。没有发现食物过敏、哮喘或花粉热单独的显著关联。结论和未来方向我们发现过敏性疾病史，特别是湿疹史与MM风险降低相关。建议进一步研究以确认发现并调查潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.