Cancer Epidemiology最新文献

{"title":"Non-smoking women need more attention in lung cancer screening: A real-world study from China","authors":"Yancheng Wang ,&nbsp;Xingchen Shang ,&nbsp;Lijie Wang ,&nbsp;Zhongmin Peng ,&nbsp;Wangang Ren","doi":"10.1016/j.canep.2025.102833","DOIUrl":"10.1016/j.canep.2025.102833","url":null,"abstract":"<div><h3>Background</h3><div>Seniors with a history of heavy smoking were defined as high-risk populations for lung cancer according to the National Comprehensive Cancer Network (NCCN) Lung Cancer Screening Guideline. We did a real-world study to explore the efficacy of the current NCCN Lung Cancer Screening Guidelines in the context of the real-life Chinese populations and possible directions for improvement.</div></div><div><h3>Methods</h3><div>We collected hospital data from 2595 consecutive patients first diagnosed with lung cancer, comprising 1288 men and 1307 women. Analysing the distribution of lung cancer tumour characteristics and risk factors in different age and sex groups. Additionally, the number and proportion of high-risk populations in different sexes were calculated based on the NCCN Lung Cancer Screening Guidelines.</div></div><div><h3>Results</h3><div>There were significant differences in the distribution of tumour characteristics and risk factors across sex and age groups. The proportions of lung adenocarcinoma and non-smokers were significantly higher in female patients compared with male patients. Older male patients showed significantly higher proportions of squamous cell carcinoma and heavy smokers than younger male patients. According to the NCCN screening criteria, there were 649 high-risk men and only 12 high-risk women. The proportion of high-risk populations in the aged lung cancer patients was 58.6 % in men and 1.2 % in women.</div></div><div><h3>Conclusions</h3><div>In China, only a minority of female lung cancer patients meet the definition of the high-risk populations for the NCCN lung cancer screening guidelines. Future lung cancer screening strategies for the Chinese population should focus more on younger populations and pay greater attention to non-smoking women to avoid high rates of underdiagnosis.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102833"},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between hospitalized infections in the first 24 months of life and risk of cancer in early-mid adulthood","authors":"Dorthe C. Pedersen ,&nbsp;Lise G. Bjerregaard ,&nbsp;Karen Dybkær ,&nbsp;Rikke K. Jacobsen ,&nbsp;Danielle K. Longmore ,&nbsp;David Burgner ,&nbsp;Jennifer L. Baker ,&nbsp;Julie Aarestrup","doi":"10.1016/j.canep.2025.102835","DOIUrl":"10.1016/j.canep.2025.102835","url":null,"abstract":"<div><h3>Background</h3><div>It is increasingly recognized that early life factors play a role in the rising prevalence of cancer in young adult life. Acute childhood infections may protect against development of cancer, but evidence is limited. We investigated whether infection-related hospital contacts during the first 24 months of life were associated with the risk of cancer in early-mid adult life in a large population-based Danish cohort.</div></div><div><h3>Methods</h3><div>We included 68,538 individuals (33,569; 49.0 % women) born 1977–1996 from the Copenhagen School Health Records Register. Using individual-level linkage to national registries, we obtained information on infection-related hospital contacts between birth and 24 months and early-onset cancer (diagnosed 15–45 years). Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using Cox regressions adjusted for maternal education.</div></div><div><h3>Results</h3><div>From birth to 24 months of life, 14,718 individuals (21.5 %) had at least one infection-related hospital contact. During follow-up, 788 individuals were diagnosed with cancer. Compared to individuals who did not have an infection-related hospital contact, those who had a least one had a lower risk of early-mid adulthood cancer (HR=0.82, 95 % CI: 0.68–0.98). We found limited evidence of a dose-response inverse effect of infection-related hospital contacts on cancer risk.</div></div><div><h3>Conclusion</h3><div>Infection-related hospital contacts during the first 24 months of life was associated with a reduced risk of cancer in early-mid adult life. Replication in other populations is warranted and mechanistic studies are needed to understand the biological mechanisms underlying these epidemiological observations.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102835"},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-associated heterogeneity of F2RL3 methylation in peripheral blood highlights its associations with early-stage male lung cancer in the Chinese population","authors":"Yunhui Qu ,&nbsp;Xiuzhi Zhang ,&nbsp;Man Liu ,&nbsp;Feifei Liang ,&nbsp;Longtao Ji ,&nbsp;Jiao Su ,&nbsp;Feifei Di ,&nbsp;Jing Zhang ,&nbsp;Zhi Wang ,&nbsp;Jie Zhang ,&nbsp;Zheng Zhang ,&nbsp;Yutong Zhao ,&nbsp;Fengqi Chen ,&nbsp;Yutong Li ,&nbsp;Wanjian Gu ,&nbsp;Rongxi Yang ,&nbsp;Liping Dai ,&nbsp;Songyun Ouyang","doi":"10.1016/j.canep.2025.102834","DOIUrl":"10.1016/j.canep.2025.102834","url":null,"abstract":"<div><h3>Background</h3><div>DNA methylation alteration in peripheral blood provides a promising approach for the diagnosis of cancers. We aimed to investigate the association between blood-based methylation of <em>F2RL3</em> and lung adenocarcinoma (LUAD).</div></div><div><h3>Methods</h3><div>A total of 970 LUAD patients, 333 benign pulmonary nodes (BPNs), and 2413 normal controls (NCs) were included. The methylation levels of blood <em>F2RL3</em> were measured by mass spectrometry. The gender-associated heterogeneity of blood <em>F2RL3</em> methylation in LUAD was investigated. The blood <em>F2RL3</em> methylation associations with male LUAD were assessed by logistic regression. The relations of blood <em>F2RL3</em> hypomethylation to tumor size and lymph node involvement in male LUAD were also evaluated. Mann-Whitney and Kruskal-Wallis tests were conducted for the comparisons. Tissue <em>F2RL3</em> methylation and expression in LUAD were investigated via UALCAN database analysis.</div></div><div><h3>Results</h3><div>Blood-based <em>F2RL3</em> methylation presented significant difference between male and female LUAD patients. While, blood <em>F2RL3</em> methylation in LUAD patients were significantly lower than in BPN cases and NCs in male population. Through logistic regression analysis, the independent associations of blood <em>F2RL3</em> hypomethylation with male LUAD was identified. In addition, blood <em>F2RL3</em> methylation was correlated with tumor size and lymph nodes involvement in male LUAD patients.</div></div><div><h3>Conclusions</h3><div>In conclusion, blood-based <em>F2RL3</em> methylation might be a potential biomarker for male LUAD early detection.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102834"},"PeriodicalIF":2.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of data from cancer registries in Italy: An appraisal","authors":"Buzzoni Carlotta ,&nbsp;Russo Antonio Giampiero ,&nbsp;Zarcone Maurizio ,&nbsp;Fusco Mario ,&nbsp;Contiero Paolo ,&nbsp;Tagliabue Giovanna ,&nbsp;Fabiano Sabrina ,&nbsp;Perotti Viviana ,&nbsp;Stracci Fabrizio ,&nbsp;Mazzucco Walter ,&nbsp;Crocetti Emanuele ,&nbsp;AIRTUM Working Group","doi":"10.1016/j.canep.2025.102829","DOIUrl":"10.1016/j.canep.2025.102829","url":null,"abstract":"<div><div>We report the results of the quality assessment on data collected by cancer registries belonging to the Italian network of Cancer Registries (AIRTUM). For all malignant cancers diagnosed in 2013–2017, overall percentages of cases known from the death certificate only (DCO), and those of cases with cyto-histological confirmation (MV), were provided. The overall percentage of DCOs was small (1.2 %). The percentage of microscopic verification was overall high (87.6 %), with some variations among registries. DCO proportion varied from 0.1 % for cutaneous melanoma to 3.8 % for liver and pancreatic tumours. Differences across sites in MV proportion were linked to the different diagnostics. The rate of cases lost to follow-up was on average very low (0.7 %). This quality evaluation confirmed that data provided by the Italian cancer registries were affordable.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102829"},"PeriodicalIF":2.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of prediction models for early relapse in advanced epithelial ovarian cancer using Australian and Dutch population-based data","authors":"Sherin A. Said ,&nbsp;Joanna IntHout ,&nbsp;Hendrik Koffijberg ,&nbsp;Joanne A. de Hullu ,&nbsp;Simon E. Hyde ,&nbsp;Maaike A. van der Aa ,&nbsp;Anne M. van Altena","doi":"10.1016/j.canep.2025.102824","DOIUrl":"10.1016/j.canep.2025.102824","url":null,"abstract":"<div><h3>Objective</h3><div>To externally validate the published postoperative and <em>BRCA</em> models predictive of early relapse in patients with advanced-stage epithelial ovarian cancer (EOC) using independent Australian and Dutch cohorts.</div></div><div><h3>Methods</h3><div>Advanced-stage EOC patients diagnosed between January 1, 2002, and June 1, 2006, in Australia, and between January 1, 2016, and December 31, 2017, in the Netherlands were included. Data from patients who underwent cytoreductive surgery and platinum-based chemotherapy were used to validate both models. Missing data were addressed through multiple imputation. Model updates included recalibration-in-the-large, recalibration, and model revision, with a closed testing procedure to identify the most suitable approach. Model performance was assessed for calibration, discrimination, and the Brier score.</div></div><div><h3>Results</h3><div>The Australian cohort (N = 1334) included 457 early relapsers and 859 late or non-relapsers, showing baseline differences compared to the development cohort. Discrimination was adequate for both the postoperative and <em>BRCA</em> models (c-statistics: 0.69 and 0.70, respectively). The postoperative model required full revision, while recalibration-in-the-large was sufficient for the <em>BRCA</em> model in the Australian cohort. The Dutch cohort (N = 1212) included 283 early relapsers and 929 late or non-relapsers, with baseline characteristics similar to those of the development cohort. Both models demonstrated adequate discrimination (c-statistics: 0.71 and 0.70, respectively). Recalibration-in-the-large corrected miscalibration in the Dutch cohort.</div></div><div><h3>Conclusion</h3><div>The postoperative and <em>BRCA</em> model were successfully validated for predicting early relapse in advanced-stage EOC patients, confirming their robustness. However, local data updates are advised to enhance accuracy across clinical settings. Online calculators were built for clinical use (<span><span>Link 1</span><svg><path></path></svg></span>; <span><span>Link 2</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102824"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive geriatric assessment and early treatment failure in nonagenarian patients with cancer, a retrospective monocentric study","authors":"Aglaé Guerin ,&nbsp;Zoé ap Thomas ,&nbsp;Céline Nagera-Lazarovici ,&nbsp;Geoffroy Beraud-Chaulet ,&nbsp;Mariana Iacob ,&nbsp;Florence Canoui-Poitrine ,&nbsp;Elena Paillaud ,&nbsp;Capucine Baldini ,&nbsp;Arnaud Pagès ,&nbsp;Maxime Frélaut","doi":"10.1016/j.canep.2025.102830","DOIUrl":"10.1016/j.canep.2025.102830","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of cancer among patients aged over 90 is increasing, but this population is poorly described in literature. This underrepresentation complicates decision-making for cancer treatments, despite the contribution of comprehensive geriatric assessment (CGA). This study aimed to describe early failure of specific anti-cancer treatments in a population of nonagenarians treated in a Comprehensive Cancer Center after undergoing a CGA.</div></div><div><h3>Methods</h3><div>This retrospective, monocentric cohort study included patients aged over 90 referred to an oncogeriatric team for CGA between 2019 and 2023, regardless of cancer type or planned treatment. The primary endpoint was the early treatment failure rate within 3 months of the initiation of treatment, defined as unplanned discontinuation, progression, or death.</div></div><div><h3>Results</h3><div>119 patients were included, with a median age of 91 years (range: 90–99 years), 53 % were men. The most common cancers were skin (30 %), head and neck (24 %), genito-urinary (12 %), and breast cancers (11 %). Most patients were independent for activities of daily living with a median ADL score of 6/6 and IADL score of 3/4. They had an average of 1.3 severe comorbidities. Half of them suffered from undernutrition. The geriatric oncology team recommended 53.8 % treatment modifications (94.5 % de-escalation). The most common treatments received were radiotherapy (27 %), surgery (18 %), hormonal therapy (10 %) and chemotherapy (9 %). A quarter of the patients received exclusive supportive care. Among patients receiving specific treatment, early failure occurred in 22.7 % (20/88). The 6-month survival probability from initiation of treatment was 69.2 % (95 % CI: 60.3 %, 76.8 %), varying significantly by treatment intent: 93.9 % (95 % CI: 80.4 %, 98.3 %) for curative treatments, 77.4 % (95 % CI: 64.5 %, 86.6 %) for palliative treatments, and 26.8 % (95 % CI: 14.3 %, 44.6 %) for exclusive supportive care.</div></div><div><h3>Conclusion</h3><div>In this population of nonagenarians, who benefit from a CGA to identify and manage patient frailties, anti-cancer treatments were carried out with few early treatment failures.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102830"},"PeriodicalIF":2.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to per- and poly-fluoroalkyl substances and hematological cancer: A systematic review and meta-analysis","authors":"Michele Sassano ,&nbsp;Sirui Zhang ,&nbsp;Elizabeth Maria Kappil ,&nbsp;Tongzhang Zheng ,&nbsp;Paolo Boffetta ,&nbsp;Monireh Sadat Seyyedsalehi","doi":"10.1016/j.canep.2025.102831","DOIUrl":"10.1016/j.canep.2025.102831","url":null,"abstract":"<div><div>Recent literature suggests that exposure to per- and polyfluoroalkyl substances (PFAS) may be associated with increased cancer risk. However, evidence regarding their association with hematological cancers is inconclusive. Hence, we aimed to summarize findings of epidemiological studies on the issue. We conducted a systematic review by searching Pubmed and Scopus in April 2025 to identify studies on the association between PFAS and cancer types other than liver, kidney, and testis. We pooled relative risks (RRs) and 95 % confidence intervals (CIs) for the association between PFAS exposure and hematological cancers with restricted maximum likelihood method. Fourteen studies were included in the review. We found pooled RRs of 1.04 (95 % CI: 0.98, 1.10; I²=12.0 %, <em>p</em>_het=0.332), 1.04 (95 % CI: 0.95, 1.14; I²=0.0 %, <em>p</em>_het=0.523), and 1.06 (95 % CI: 0.94, 1.19; I²=42.9 %, <em>p</em>_het=0.105) for the association between environmental or occupational PFAS exposure and total hematological cancer, leukemia, and lymphoma, respectively. As for types of lymphoma, environmental or occupational PFAS exposure was associated with incidence of non-Hodgkin lymphoma (RR: 1.15; 95 % CI: 1.01, 1.29; I²=0.0 %, <em>p</em>_het=0.579), while no association with its mortality or with Hodgkin lymphoma was observed. The RR for the association between high serum levels of perfluorooctanoic acid and total hematological cancer was 1.13 (95 % CI: 0.72, 1.75; I²=64.6 %%, <em>p</em>_het=0.023). Our results are suggestive of an association between PFAS exposure and non-Hodgkin lymphoma. Weak associations were also observed for total hematological cancer and leukemia among male individuals. Due to potential exposure misclassification in included studies, further evidence is needed to confirm our findings.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102831"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of carcinomatosis","authors":"Kyle A. Mani ,&nbsp;Jun Lu ,&nbsp;Eric J. Lehrer ,&nbsp;Ming Wang ,&nbsp;Lauren E. Henke ,&nbsp;Richard S. Hoehn ,&nbsp;Nicholas G. Zaorsky","doi":"10.1016/j.canep.2025.102815","DOIUrl":"10.1016/j.canep.2025.102815","url":null,"abstract":"<div><h3>Background</h3><div>Carcinomatosis is an advanced form of metastatic cancer, which has been thought to be an invariantly fatal disease. We characterized prognostic factors for overall survival (OS) in patients with de-novo carcinomatosis.</div></div><div><h3>Methods</h3><div>Patients were identified from the SEER database from 1/1/2016–12/31/2020. Kaplan–Meier method and log-rank test were used to evaluate OS and a Cox proportional hazards model was used to calculate adjusted hazard ratios (aHR) with 95 % confidence intervals (CIs).</div><div>We included patients with carcinomatosis across 30 primary sites. The most common primary tumors were colorectal, pancreas, ovary, and lung &amp; bronchus, and stomach.</div></div><div><h3>Results</h3><div>Among newly diagnosed cancer patients in SEER, a total of 3131 (59.7 % female, 80.1 % White) patients with carcinomatosis were identified, corresponding to an incidence of 9.0 per 1000,000 persons. Of all patients with metastatic disease, only 0.17 % were diagnosed with carcinomatosis. Compared to patients with de novo metastatic disease without carcinomatosis (i.e., those with metastases limited to the brain, bone, liver, or lung), patients with carcinomatosis were associated with over twice the risk of mortality (aHR = 2.3, 95 % CI: 2.2–2.5). The 1-year OS for patients with carcinomatosis was 35.8 % (95 % CI: 34.0 %–37.7 %). The most common primary sites included: colorectal (14.8 %), pancreas (14.8 %), ovary (9.8 %), and lung &amp; bronchus (8.9 %). Patients with appendiceal (1-year OS: 88.2 %, 95 % CI: 81.8 %–95.1 %) and ovarian (1-year OS: 58.7 %, 95 % CI: 53.0 %–65.0 %) carcinomatosis had markedly longer survival compared to patients with carcinomatosis from other primary sites. Patients who were at highest risk of death are more likely to be older; male; Black; have more advanced T and N categories; and/or have synchronous metastases (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Carcinomatosis is associated with poorer OS compared to other forms of metastases. Patients with ovarian and appendiceal tumors have markedly longer survival.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102815"},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individuals from culturally and linguistically diverse backgrounds have more advanced prostate cancer at diagnosis in Victoria, Australia","authors":"Koku Sisay Tamirat ,&nbsp;Michael James Leach ,&nbsp;Nathan Papa ,&nbsp;Jeremy Millar ,&nbsp;Eli Ristevski","doi":"10.1016/j.canep.2025.102827","DOIUrl":"10.1016/j.canep.2025.102827","url":null,"abstract":"<div><h3>Introduction</h3><div>The Australian Cancer Plan prioritises individuals from culturally and linguistically diverse (CALD) backgrounds as a focus of interventions aimed at improving cancer care experiences and outcomes. We aimed to investigate differences in the National Comprehensive Cancer Network (NCCN) risk category classification at prostate cancer (PCa) diagnosis between CALD and non-CALD populations.</div></div><div><h3>Methods</h3><div>We included Victorian Prostate Cancer Outcomes Registry registrants with a PCa diagnosis (February 2009-August 2022) and country-of-birth data. CALD status was defined as birth in a mainly non-English-speaking country (CALD) versus Australia or a mainly English-speaking country (MESC). CALD individuals were further sub-grouped by preferred spoken language: English-speaking and non-English-speaking. We estimated the effect of CALD status on NCCN risk categories using partial proportional ordinal logistic regression.</div></div><div><h3>Results</h3><div>There were 25,951 individuals: 18,392 (71 %) Australian-born, 5046 (19 %) CALD and 2513 (10 %) MESC-born. Of 4872 CALD individuals with preferred-language data, 498 (10 %) preferred speaking a language other than English. Compared to Australian-born individuals, non-English-speaking CALD individuals presented with less low-risk (15 % vs 22 %) but more high-risk (32 % vs 21 %) and metastatic (18 % vs 8 %) disease. CALD individuals had significantly more advanced (regional or metastatic) disease than Australian-born individuals (adjusted odds ratio [aOR]=1.17, 95 % confidence interval [CI]=1.06–1.29). Non-English-speaking CALD individuals had significantly more advanced PCa (aOR=1.54, 95 % CI=1.23–1.94).</div></div><div><h3>Conclusions</h3><div>Individuals from CALD backgrounds had greater odds of presenting with high-risk or advanced PCa. Improving early detection of PCa for CALD individuals requires investigation of underlying factors to plan effective interventions.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102827"},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximal weight change during adulthood and breast cancer risk: A 14-year follow-up of the Guangzhou Biobank Cohort Study","authors":"Xiao Yi Lin ,&nbsp;Jiao Wang ,&nbsp;Wei Sen Zhang ,&nbsp;Chao Qiang Jiang ,&nbsp;Ya Li Jin ,&nbsp;Kar Keung Cheng ,&nbsp;Tai Hing Lam ,&nbsp;Lin Xu","doi":"10.1016/j.canep.2025.102825","DOIUrl":"10.1016/j.canep.2025.102825","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a risk factor for breast cancer (BC) after menopause, but the association of weight fluctuation during adulthood with BC risk remains unknown.</div></div><div><h3>Methods</h3><div>A total of 20,056 female participants aged 50 years or older from the Guangzhou Biobank Cohort Study (2003–2008) were followed up until 2020 through linkage with the cancer registry. At baseline, maximal weight change was defined as the difference between the highest and lowest weight since age 18. Cox proportional hazards regression was used, adjusting for potential confounders.</div></div><div><h3>Results</h3><div>During an average follow-up of 14.2 years, 326 BC cases were identified. A maximal weight gain of 5 kg or more since age 18 was associated with a higher BC risk, compared to a weight change of less than 5 kg (adjusted hazard ratio [adHR] 1.36, 95 % confidence interval [CI] 1.02–1.81; <em>P</em> = 0.03). Among participants who gained 5 kg or more, each additional kilogram was associated with a 2 % higher BC risk (adHR 1.02 per 1 kg, 95 % CI 1.00–1.04; <em>P</em> = 0.02). Similar patterns were found in women who reached the highest weight before the age of 50 (adHR 1.06 per 1 kg, 95 % CI 1.03–1.08; <em>P</em> &lt; 0.001). Additionally, a 1-kg increase in weight was associated with a 10 % (95 % CI 1.05–1.16; <em>P</em> &lt; 0.001) higher risk of BC in women who weighed more than peers at age 20.</div></div><div><h3>Conclusions</h3><div>These findings suggest that preventing excessive weight gain in adulthood, particularly among women who reached their highest weight before 50 years of age and who were heavier than peers at age 20, may reduce BC risk. Weight management should be emphasized, both at the highest and earliest adult years, in mitigating BC risk.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102825"},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}