乳腺癌幸存者能从乳房x光检查中获益吗？一项基于人群的研究

IF 2.3 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-09-04 DOI:10.1016/j.canep.2025.102910

Bayan Sardini , Mette Bach Larsen , Sisse Helle Njor

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引用次数: 0

摘要

背景：在一般人群中，乳房x光检查可使乳腺癌死亡率降低约25% %，因此也可能使乳腺癌幸存者受益。然而，它对这一群体死亡率的影响仍未得到研究。我们的目的是估计乳房x光检查对这一人群乳腺癌死亡率的影响。方法：我们使用的数据来自丹麦Funen地区乳房x光检查项目的邀请（1993-2007），该项目于2008年在全国范围内推广。被邀请的幸存者（研究组）的乳腺癌死亡率与没有筛查项目的县的同龄幸存者（对照组）进行比较。结果研究和对照组包括2109名受邀乳腺癌幸存者和15417名非受邀乳腺癌幸存者。其中，406人（19 %）和3385人（22 %）在随访期间死于乳腺癌。在22年的随访中，受邀者与未受邀者的相对风险为0.88（95 %CI: 0.81-0.97）。与未被邀请的乳腺癌幸存者对照组相比，参与者的相对风险为0.62（95 %CI: 0.51-0.76）。结论乳腺x线摄影筛查对乳腺癌幸存者死亡率的降低作用小于对普通人群的降低作用。然而，这很可能是由于乳腺癌幸存者的参与率较低。

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Do breast cancer survivors benefit from mammography screening? A population-based study

Background

Mammography screening reduces breast cancer mortality by approximately 25 % in the general population and might therefore also benefit breast cancer survivors. However, its impact on mortality rates in this group remains unstudied. We aimed to estimate the effect of mammography screening on breast cancer mortality in this population.

Methods

We used data from invitations to the regional mammography screening program in Funen, Denmark (1993–2007), before the nationwide program's rollout in 2008. Breast cancer mortality among invited survivors (study group) was compared to survivors of similar age in counties without screening programs (control group).

Results

The study and control groups comprised 2109 invited breast cancer survivors and 15,417 non-invited breast cancer survivors. Of those, 406 (19 %) and 3385 (22 %) died from breast cancer within the follow-up period. The relative risk for invited versus not invited at 22 years of follow-up was 0.88 (95 %CI: 0.81–0.97). The relative risk for participants compared to a similar group in the control group of non-invited breast cancer survivors was 0.62 (95 %CI: 0.51–0.76).

Conclusions

Mammography screening might reduce breast cancer mortality less among breast cancer survivors than among the general population. However, this is most likely due to a lower participation rate among breast cancer survivors.

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.