Description and recent trends (2011–2019) of early-onset colorectal cancer incidence in Texas

IF 2.3 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-09-16 DOI:10.1016/j.canep.2025.102927

Yahan Zhang , Hyeun Ah Kang , Srinivas Joga Ivatury , Claire Sokas

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引用次数: 0

Abstract

Background

Early-onset colorectal cancer (EO-CRC), diagnosed in individuals under 50, has seen rising incidence rates, while average-onset colorectal cancer rates decline. To understand EO-CRC burden across regions and patient characteristics, detailed incidence data are essential. With Texas's large population and unique demographics, this study examines recent trends in age-adjusted EO-CRC incidence.

Methods

This cross-sectional analysis used 2011–2019 Texas Cancer Registry (TCR) data. The incidence rate of EO-CRC was adjusted to the 2000 US standard population and was stratified by cancer type, sex, race/ethnicity, and stage at diagnosis. The number of EO-CRC cases between 2011 and 2019 was mapped to the Texas counties.

Results

In the study period, a total of 11,848 EO-CRC (7511 colon cancer [EO-CC] and 4337 rectal cancer [EO-RC]) cases were identified. Over 50 % of cases were diagnosed before the age of 45. The age-adjusted incidence rate (AAIR) of EO-CRC showed a slightly increasing trend over the study period (AAIR range: 10.4/100,000 persons [95 % CI = 9.8–11.0]- 12.7/100,000 persons [95 % CI = 12.0–13.3]). The AAIRs of EO-CRC among males were higher than that of females. Non-Hispanic (NH) White population had the highest AAIR, followed by the Black population and Hispanic population, while other races/ethnicities had the lowest AAIR of EO-CRC. The incidence rate of EO-CRC diagnosed at the regional stage was the highest and showed the steepest increasing trend. While EO-CRC case density by county reflects the population density, incidence rates were higher in rural counties.

Conclusion

The incidence of EO-CRC in Texas showed an increasing trend from 2011 to 2019, with notable disparities by sex, race/ethnicity, and cancer stage.

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德克萨斯州早发性结直肠癌发病率描述及近期趋势（2011-2019）

背景：早发性结直肠癌（EO-CRC）在50岁以下的人群中被诊断出来，发病率上升，而平均发病的结直肠癌发病率下降。为了了解不同地区的EO-CRC负担和患者特征，详细的发病率数据是必不可少的。由于德克萨斯州人口众多，人口结构独特，本研究探讨了年龄调整后的EO-CRC发病率的最新趋势。方法：采用2011-2019年德克萨斯州癌症登记处（TCR）数据进行横断面分析。EO-CRC的发病率调整为2000年美国标准人群，并按癌症类型、性别、种族/民族和诊断分期进行分层。2011年至2019年期间的EO-CRC病例数被映射到德克萨斯州各县。结果：研究期间共发现EO-CRC 11,848例（其中结肠癌[EO-CC] 7511例，直肠癌[EO-RC] 4337例）。超过50% %的病例在45岁之前被诊断出来。EO-CRC的年龄调整发病率（AAIR）在研究期间呈轻微上升趋势（AAIR范围：10.4/100,000人[95 % CI = 9.8-11.0]- 12.7/100,000人[95 % CI = 12.0-13.3]）。男性的EO-CRC指数高于女性。非西班牙裔（NH）白人的AAIR最高，黑人次之，西班牙裔次之，其他种族的AAIR最低。区域阶段诊断的EO-CRC发病率最高，且呈最急剧的上升趋势。各县的EO-CRC病例密度反映了人口密度，但农村县发病率较高。结论：2011 - 2019年，德克萨斯州EO-CRC发病率呈上升趋势，性别、种族和癌症分期差异显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.