Neuroscience and Biobehavioral Reviews最新文献

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Survival in a world of complex dangers 在充满复杂危险的世界中生存。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-16 DOI: 10.1016/j.neubiorev.2024.105924
Dean Mobbs , Toby Wise , Sarah Tashjian , JiaJin Zhang , Karl Friston , Drew Headley
{"title":"Survival in a world of complex dangers","authors":"Dean Mobbs ,&nbsp;Toby Wise ,&nbsp;Sarah Tashjian ,&nbsp;JiaJin Zhang ,&nbsp;Karl Friston ,&nbsp;Drew Headley","doi":"10.1016/j.neubiorev.2024.105924","DOIUrl":"10.1016/j.neubiorev.2024.105924","url":null,"abstract":"<div><div>How did our nomadic ancestors continually adapt to the seemingly limitless and unpredictable number of dangers in the natural world? We argue that human defensive behaviors are dynamically constructed to facilitate survival in capricious and itinerant environments. We first hypothesize that internal and external states result in state constructions that combine to form a meta-representation. When a threat is detected, it triggers the action construction. Action constructions are formed through two contiguous survival strategies: generalization strategies, which are used when encountering new threats and ecologies. Generalization strategies are associated with cognitive representations that have high dimensionality and which furnish flexible psychological constructs, including relations between threats, and imagination, and which converge through the construction of defensive states. We posit that generalization strategies drive ‘explorative’ behaviors including information seeking, where the goal is to increase knowledge that can be used to mitigate current and future threats. Conversely, specialization strategies entail lower dimensional representations, which underpin specialized, sometimes reflexive, or habitual survival behaviors that are ‘exploitative’. Together, these strategies capture a central adaptive feature of human survival systems: self-preservation in response to a myriad of threats.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105924"},"PeriodicalIF":7.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conscious experiences during non-rapid eye movement sleep parasomnias 非快速眼动睡眠寄生虫期间的意识体验。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-16 DOI: 10.1016/j.neubiorev.2024.105919
Anna Castelnovo , Francesca Siclari , Sara Spaggiari , Dolores Borth , Mauro Manconi , Isabelle Arnulf , Carlos H. Schenck
{"title":"Conscious experiences during non-rapid eye movement sleep parasomnias","authors":"Anna Castelnovo ,&nbsp;Francesca Siclari ,&nbsp;Sara Spaggiari ,&nbsp;Dolores Borth ,&nbsp;Mauro Manconi ,&nbsp;Isabelle Arnulf ,&nbsp;Carlos H. Schenck","doi":"10.1016/j.neubiorev.2024.105919","DOIUrl":"10.1016/j.neubiorev.2024.105919","url":null,"abstract":"<div><div>Disorders of Arousal (DOA) are non-rapid eye movement (NREM) parasomnias traditionally regarded as unconscious states. However, recent research challenges this assumption. This narrative review aims to explore the presence and qualitative features of conscious experiences in patients with DOA during their episodes. The literature indicates a higher recall of conscious experiences during DOA episodes than previously believed, estimated at about 50–60 % in adults (immediately post-episode). Data on children are limited but suggest a lower recall rate (&lt;30 % when interviewed retrospectively). Patient reports range from brief scenic fragments to elaborate scenarios with plot development, often fraught with negative emotions and misfortunes and with considerable correspondence between subjective experiences and observed behaviors. In many of the described cases, patients appear to enact their dreams, entering a hallucinatory state where internally generated images overlay external percepts. The potential implications for clinical management, research endeavors, and legal considerations regarding nocturnal violence, along with existing limitations and controversial points, are discussed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105919"},"PeriodicalIF":7.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the intricacies of health syndemics to improve population mental health and prevention 揭示健康综合症的复杂性,改善人口心理健康和预防。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-15 DOI: 10.1016/j.neubiorev.2024.105921
Sian Lowri Griffiths
{"title":"Unravelling the intricacies of health syndemics to improve population mental health and prevention","authors":"Sian Lowri Griffiths","doi":"10.1016/j.neubiorev.2024.105921","DOIUrl":"10.1016/j.neubiorev.2024.105921","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105921"},"PeriodicalIF":7.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Music and states of consciousness: A narrative review of the broader significance of music to understanding absorption, mind wandering and creative thought 音乐与意识状态:音乐对理解吸收、思维游离和创造性思维的广泛意义的叙述性回顾
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-11 DOI: 10.1016/j.neubiorev.2024.105920
Pedro T. Palhares , Madalina I. Sas , Óscar F. Gonçalves
{"title":"Music and states of consciousness: A narrative review of the broader significance of music to understanding absorption, mind wandering and creative thought","authors":"Pedro T. Palhares ,&nbsp;Madalina I. Sas ,&nbsp;Óscar F. Gonçalves","doi":"10.1016/j.neubiorev.2024.105920","DOIUrl":"10.1016/j.neubiorev.2024.105920","url":null,"abstract":"<div><div>Due to music's extraordinary capacity to temporarily alter mental and physical states, the domain of <em>musical experience</em> offers a natural and accessible field of investigation for the study of states of consciousness. However, despite the continued emergence of music-related investigations into conscious experience, their research paradigms remain on the fringes of consciousness research, with the broader significance of their contributions often overlooked. In this narrative review, we aimed to address this gap by offering a twofold contribution. Firstly, we have highlighted and critically assessed key contributions of empirical research in music psychology and music neuroscience to our understanding of non-ordinary states of consciousness, such as absorption, mind wandering and creative thought, emphasizing the broader significance of exploring consciousness through music. Secondly, we have identified the unique aspects of music that offer special insight into consciousness and discussed how these aspects can shape future investigations. Overall, our review underscores the importance of integrating music into consciousness research and highlights avenues for future exploration in this interdisciplinary field.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105920"},"PeriodicalIF":7.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naturalistic assessments across the lifespan: Systematic review of inhibition measures in ecological settings 跨越生命周期的自然评估:生态环境中抑制测量的系统回顾
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-10 DOI: 10.1016/j.neubiorev.2024.105915
Larisa-Maria Dina , Tim J. Smith , Tobias U. Hauser , Eleanor J. Dommett
{"title":"Naturalistic assessments across the lifespan: Systematic review of inhibition measures in ecological settings","authors":"Larisa-Maria Dina ,&nbsp;Tim J. Smith ,&nbsp;Tobias U. Hauser ,&nbsp;Eleanor J. Dommett","doi":"10.1016/j.neubiorev.2024.105915","DOIUrl":"10.1016/j.neubiorev.2024.105915","url":null,"abstract":"<div><div>Inhibitory control is essential for our everyday lives. Despite this, it is commonly assessed using non-naturalistic assessments. In this systematic review, we argue for the importance of taking an ecological approach to assess cognition. The aims are to present the state-of-knowledge in naturalistic assessments of inhibitory control, focusing on their methodological characteristics, including psychometric properties and user experience. PubMed, PsycINFO and Web of Science were searched until September 2024. Studies were included if they used at least one naturalistic method of assessing inhibition. The included studies (N=64) were grouped into three methodological categories: gamification, virtual reality, and brief, repeated assessments in participants’ usual environment in the form of ecological momentary assessments. Sample sizes spanned three orders of magnitude (N=12–22,098). We report considerable heterogeneity in the types of tasks used, and the psychometric details reported. Nonetheless, naturalistic tasks were generally comparable with standardised equivalents, although some tasks assessed mixed-domain constructs. Tasks were feasible and acceptable for participants, with generally high completion rates and engagement. Recommendations for future research are discussed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105915"},"PeriodicalIF":7.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of the quantitative markers of speech and language of the frontotemporal degeneration spectrum and their potential for cross-linguistic implementation 对前额颞叶变性谱系言语和语言定量标记及其跨语言应用潜力的系统性综述》(A Systematic Review of the Quantitative Markers of speech and language of the Frontotemporal Degeneration Spectrum and their potential for cross linguistic implementation)。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-10 DOI: 10.1016/j.neubiorev.2024.105909
Rosie Coppieters , Arabella Bouzigues , Lize Jiskoot , Maxime Montembeault , Boon Lead Tee , Genetic Frontotemporal Dementia Initiative (GENFI) , Jonathan D. Rohrer , Rose Bruffaerts
{"title":"A systematic review of the quantitative markers of speech and language of the frontotemporal degeneration spectrum and their potential for cross-linguistic implementation","authors":"Rosie Coppieters ,&nbsp;Arabella Bouzigues ,&nbsp;Lize Jiskoot ,&nbsp;Maxime Montembeault ,&nbsp;Boon Lead Tee ,&nbsp;Genetic Frontotemporal Dementia Initiative (GENFI) ,&nbsp;Jonathan D. Rohrer ,&nbsp;Rose Bruffaerts","doi":"10.1016/j.neubiorev.2024.105909","DOIUrl":"10.1016/j.neubiorev.2024.105909","url":null,"abstract":"<div><div>Frontotemporal dementia (FTD) is a neurodegenerative disease spectrum with an urgent need for reliable biomarkers for early diagnosis and monitoring. Speech and language changes occur in the early stages of FTD and offer a potential non-invasive, early, and accessible diagnostic tool. The use of speech and language markers in this disease spectrum is limited by the fact that most studies investigate English-speaking patients. This systematic review examines the literature on psychoacoustic and linguistic features of speech that occur across the FTD spectrum across as many different languages as possible. 76 papers were identified that investigate psychoacoustic and linguistic markers in discursive speech. 75 % of these papers studied English-speaking patients. The most generalizable features found across different languages, are speech rate, articulation rate, pause frequency, total pause duration, noun-verb ratio, and total number of nouns. While there are clear interlinguistic differences across patient groups, the results show promise for implementation of cross-linguistic markers of speech and language across the FTD spectrum particularly for psychoacoustic features.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105909"},"PeriodicalIF":7.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D-optical motion capturing examination of sensori- and psychomotor abnormalities in mental disorders: Progress and perspectives 三维光学运动捕捉检查精神障碍中的感觉和精神运动异常:进展与展望。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-09 DOI: 10.1016/j.neubiorev.2024.105917
Dilsa Cemre Akkoc Altinok , Kristin Ohl , Sebastian Volkmer , Geva A. Brandt , Stefan Fritze , Dusan Hirjak
{"title":"3D-optical motion capturing examination of sensori- and psychomotor abnormalities in mental disorders: Progress and perspectives","authors":"Dilsa Cemre Akkoc Altinok ,&nbsp;Kristin Ohl ,&nbsp;Sebastian Volkmer ,&nbsp;Geva A. Brandt ,&nbsp;Stefan Fritze ,&nbsp;Dusan Hirjak","doi":"10.1016/j.neubiorev.2024.105917","DOIUrl":"10.1016/j.neubiorev.2024.105917","url":null,"abstract":"<div><div>Sensori-/psychomotor abnormalities refer to a wide range of disturbances in individual motor, affective and behavioral functions that are often observed in mental disorders. However, many of these studies have mainly used clinical rating scales, which can be potentially confounded by observer bias and are not able to detect subtle sensori-/psychomotor abnormalities. Yet, an innovative three-dimensional (3D) optical motion capturing technology (MoCap) can provide more objective and quantifiable data about movements and posture in psychiatric patients. To draw attention to recent rapid progress in the field, we performed a systematic review using PubMed, Medline, Embase, and Web of Science until May 01st 2024. We included 55 studies in the qualitative analysis and gait was the most examined movement. The identified studies suggested that sensori-/psychomotor abnormalities in neurodevelopmental, mood, schizophrenia spectrum and neurocognitive disorders are associated with alterations in spatiotemporal parameters (speed, step width, length and height; stance time, swing time, double limb support time, phases duration, adjusting sway, acceleration, etc.) during various movements such as walking, running, upper body, hand and head movements. Some studies highlighted the advantages of 3D optical MoCap systems over traditional rating scales and measurements such as actigraphy and ultrasound gait analyses. 3D optical MoCap systems are susceptible to detecting differences not only between patients with mental disorders and healthy persons but also among at-risk individuals exhibiting subtle sensori-/psychomotor abnormalities. Overall, 3D optical MoCap systems hold promise for objectively examining sensori-/psychomotor abnormalities, making them valuable tools for use in future clinical trials.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105917"},"PeriodicalIF":7.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the mentalizing brain: An ALE meta-analysis to differentiate the representation of social scenes and ages on theory of mind 绘制心智化大脑图谱:通过 ALE 元分析,区分社会场景和年龄对心智理论的表征。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-09 DOI: 10.1016/j.neubiorev.2024.105918
Runchen Gan , Yidan Qiu , Jiajun Liao , Yuting Zhang , Jingyi Wu , Xiaoqi Peng , Tatia Mei-chun Lee , Ruiwang Huang
{"title":"Mapping the mentalizing brain: An ALE meta-analysis to differentiate the representation of social scenes and ages on theory of mind","authors":"Runchen Gan ,&nbsp;Yidan Qiu ,&nbsp;Jiajun Liao ,&nbsp;Yuting Zhang ,&nbsp;Jingyi Wu ,&nbsp;Xiaoqi Peng ,&nbsp;Tatia Mei-chun Lee ,&nbsp;Ruiwang Huang","doi":"10.1016/j.neubiorev.2024.105918","DOIUrl":"10.1016/j.neubiorev.2024.105918","url":null,"abstract":"<div><div>Theory of mind (ToM) involves understanding others' mental states and relies on brain regions like the temporoparietal junction (TPJ) and medial prefrontal cortex (mPFC). This meta-analytic review categorizes ToM studies into six sub-components across three pairs: (1) Theory of collective mind (ToCM) and individualized theory of mind (iToM), (2) Social intention ToM and private intention ToM, and (3) ToM in adults and ToM in children. We conducted coordinate-based activation likelihood estimation (ALE) analyses and meta-analytic connectivity modeling (MACM) for each sub-component. We found that the ToM components utilized in social or group situations were associated with both the dorsomedial PFC (dmPFC) and right superior temporal sulcus (STS), whereas the ToM components focused on personal concentration were associated with both the lateral PFC and the left STS. The coactivation patterns for the group and age sub-component pairs showed significant spatial overlap with the language networks. These findings indicate that ToM is a multidimensional construct that is related to distinct functional networks for processing each of the ToM sub-components.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105918"},"PeriodicalIF":7.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporating sex and gender considerations in research on psychosocial work exposures and cardiovascular diseases: A systematic review of 55 prospective studies 将性别因素纳入社会心理工作与心血管疾病的研究:对 55 项前瞻性研究的系统回顾。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-05 DOI: 10.1016/j.neubiorev.2024.105916
Azita Zahiriharsini , Mahée Gilbert-Ouimet , Valérie Hervieux , Xavier Trudel , Léonie Matteau , Laura Jalbert , Olha Svyntozelska , Juliette Demers , Annie LeBlanc , Peter Smith
{"title":"Incorporating sex and gender considerations in research on psychosocial work exposures and cardiovascular diseases: A systematic review of 55 prospective studies","authors":"Azita Zahiriharsini ,&nbsp;Mahée Gilbert-Ouimet ,&nbsp;Valérie Hervieux ,&nbsp;Xavier Trudel ,&nbsp;Léonie Matteau ,&nbsp;Laura Jalbert ,&nbsp;Olha Svyntozelska ,&nbsp;Juliette Demers ,&nbsp;Annie LeBlanc ,&nbsp;Peter Smith","doi":"10.1016/j.neubiorev.2024.105916","DOIUrl":"10.1016/j.neubiorev.2024.105916","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality, with disparities observed between males and females. Psychosocial work exposures (PWE), including workload, job control, reward and long working hours, are associated with CVD development. Despite higher prevalence among females, the association with CVD is consistently observed in males, with limited explanations for these differences. This study aimed to examine the consideration of sex and gender in prospective studies within systematic reviews on PWE — specifically, the demand-control model, the effort-reward imbalance model, and long working hours — and CVD. Conducting a systematic review, we assessed sex and gender considerations using criteria from the Sex and Gender Equity in Research (SAGER) guidelines. While most studies recognized potential sex and gender differences in the associations between PWE and CVD, only about half of the 28 studies that included both sexes (15 studies) analyzed females and males separately. Moreover, few studies included criteria for sex- and gender-based analyses. Less than half of the studies (23 studies) incorporated a sex and/or gender perspective to discuss observed differences and similarities between men and women. Although there is a rising trend in integrating sex and gender considerations, significant gaps persist in methodologies and reporting, highlighting the need for comprehensive incorporation of sex and gender considerations to bolster CVD prevention strategies and policies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105916"},"PeriodicalIF":7.5,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspective role of Substance P in Amyotrophic Lateral Sclerosis: From neuronal vulnerability to neuroprotection 物质 P 在肌萎缩侧索硬化症中的前瞻性作用:从神经元脆弱性到神经保护。
IF 7.5 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-05 DOI: 10.1016/j.neubiorev.2024.105914
Paola Tirassa , Pamela Rosso , Elena Fico , Marco Marenco , Fabiana Mallone , Magda Gharbiya , Alessandro Lambiase , Cinzia Severini
{"title":"Perspective role of Substance P in Amyotrophic Lateral Sclerosis: From neuronal vulnerability to neuroprotection","authors":"Paola Tirassa ,&nbsp;Pamela Rosso ,&nbsp;Elena Fico ,&nbsp;Marco Marenco ,&nbsp;Fabiana Mallone ,&nbsp;Magda Gharbiya ,&nbsp;Alessandro Lambiase ,&nbsp;Cinzia Severini","doi":"10.1016/j.neubiorev.2024.105914","DOIUrl":"10.1016/j.neubiorev.2024.105914","url":null,"abstract":"<div><div>The neuropeptide Substance P (SP) and its preferred Neurokinin1 Receptor (NK1R) are known to participate in the physiopathology of neurodegenerative diseases and mainly exert a neuroprotective role. In the present work, we have described the involvement of SP and NK1R in Amyotrophic Lateral Sclerosis (ALS). This was demonstrated by the detection of altered levels of SP in the brain, spinal cord and cerebrospinal fluid (CSF) of patients and preclinical models of ALS, and by its ability to inhibit excitotoxicity-induced neurodegeneration in ALS animal models. These data are supported by results indicating an excitatory effect of SP at the motor neuron (MN) level, which promotes locomotor activity. ALS patients are characterized by a differential susceptibility to MNs degeneration, since sphincters and extraocular muscles are classically spared. It is hypothesized that SP may play a role in the maintenance of the ocular system and the innervation of the pelvic floor by contributing directly or indirectly to the selective resistance of this subset of MNs.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105914"},"PeriodicalIF":7.5,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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