Neuroscience and Biobehavioral Reviews最新文献

{"title":"Examining the impact of physiological stress on time perception: A systematic review and meta-analysis","authors":"Philippe Vignaud ,&nbsp;Jerôme Brunelin ,&nbsp;Perrine Galia ,&nbsp;Simon Grondin ,&nbsp;André Morin ,&nbsp;Nathalie Prieto ,&nbsp;Emmanuel Poulet ,&nbsp;William Vallet","doi":"10.1016/j.neubiorev.2025.106382","DOIUrl":"10.1016/j.neubiorev.2025.106382","url":null,"abstract":"<div><div>Stress is a ubiquitous experience that can significantly impact various aspects of human cognition and behavior, including time perception. Time perception, which refers to the ability to estimate and experience time intervals, plays a crucial role in everyday functioning and decision-making. However, whether stress affects how individuals perceive time remains unclear in literature. While some studies report that time perception can be underestimated (i.e., larger time production and shorter estimate) under certain stress conditions, others observe the opposite effect, with an overestimation of perceived time (i.e., shorter time production and larger estimate). To clarify the inconsistencies in the literature, we conducted a systematic review and meta-analysis of studies examining the effects of acute stress on time perception. The model, based on 437 participants exposed to stress and 434 control participants, demonstrated a significant effect favoring overestimated time under stress conditions (Cohen’s d = −0.40; 95 % CI: −0.7037 to −0.1016). No significant effects of task type and socio-demographic factors were observed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106382"},"PeriodicalIF":7.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the mediating effect of myokines on exercise-induced cognitive changes in older adults: A living systematic review and meta-analysis","authors":"Wouter A.J. Vints ,&nbsp;Evrim Gökçe ,&nbsp;Antoine Langeard ,&nbsp;Iuliia Pavlova ,&nbsp;Özge Selin Çevik ,&nbsp;Mohammad Mosaferi Ziaaldini ,&nbsp;Jasemin Todri ,&nbsp;Orges Lena ,&nbsp;Salit Bar Shalom ,&nbsp;Suzanne Jak ,&nbsp;Ioanna Zorba (Zormpa) ,&nbsp;Christina Karatzaferi ,&nbsp;Oron Levin ,&nbsp;Nerijus Masiulis ,&nbsp;Yael Netz ,&nbsp;On behalf of the PhysAgeNet","doi":"10.1016/j.neubiorev.2025.106381","DOIUrl":"10.1016/j.neubiorev.2025.106381","url":null,"abstract":"<div><div>Despite strong evidence linking exercise training to cognitive benefits, uncertainty remains regarding the underlying biological mechanisms, with some studies highlighting the need for greater consensus. Muscle-derived exerkines (myokines) are proposed mediators of exercise-induced effects with potential implications for mitigating age-related cognitive decline. This living systematic review and meta-analysis examined randomized controlled trials investigating the effects of exercise on both cognition and any of 1126 potential myokines in individuals aged 50 and older. From 17,177 screened records, 43 studies met inclusion criteria, reporting data on 7 neurotrophic, 11 pro-inflammatory, and 2 anti-inflammatory factors. A three-level meta-analysis revealed significantly improved cognitive performance post-exercise (SMD = 0.579) and elevated neurotrophic factor levels (SMD = 0.427) in exercise groups compared to controls, but no significant changes in pro-inflammatory or anti-inflammatory factor levels. Mediation analysis using meta-analytic structural equation modeling (MASEM) did not detect significant indirect effects of myokines on cognition, with only limited data (9 studies) reporting direct post-test correlations between myokine levels and cognitive outcomes. Exercise improved several cognitive domains and increased certain myokines, particularly BDNF, in older adults. However, current evidence is insufficient to determine whether myokines mediate these benefits, as mediation analyses were limited by small samples, incomplete reporting, and methodological constraints. Future well-powered trials with standardized protocols and comprehensive biomarker reporting are needed to clarify this mechanistic pathway. As a living review, this work will be continuously updated to refine our understanding of whether myokines mediate exercise-induced cognitive benefits in aging populations.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106381"},"PeriodicalIF":7.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-invasive brain stimulation on theory of mind and emotion processing in neuropsychiatric disorders: A systematic review and meta-analysis","authors":"Harry Kam Hung Tsui ,&nbsp;Georg S. Kranz ,&nbsp;Yingjun Zheng ,&nbsp;Janet Hui-wen Hsiao ,&nbsp;Sherry Kit Wa Chan","doi":"10.1016/j.neubiorev.2025.106380","DOIUrl":"10.1016/j.neubiorev.2025.106380","url":null,"abstract":"<div><div>Social cognitive impairments, including emotion processing (EP) and theory of mind (ToM), have been considered as transdiagnostic features across neuropsychiatric disorders, substantially affecting social functioning. While no definitive treatment exists for these deficits, non-invasive brain stimulation (NIBS) has emerged as a promising option but a comprehensive quantitative review was lacking. This systematic review and meta-analysis were conducted to evaluate the effects of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) on EP and ToM deficits across diverse neuropsychiatric disorders. Following PRISMA guidelines, eligible randomized sham-controlled trials were systematically searched. Hedges’ g was utilized to quantify effect sizes for pretest-posttest-control group designs. A total of 36 studies comprising 1486 participants were included. Meta-analyses revealed a modest yet significant effect of TMS on EP compared to sham (g = 0.295 [95 % CI, 0.065–0.524], p = 0.012), while no significant effects were found for tDCS on EP or ToM, nor of TMS on ToM. Notably, more prominent effects were observed with TMS targeting the left dorsolateral prefrontal cortex (dlPFC) and utilizing facial emotion recognition tasks. However, the high heterogeneity and limited long-term follow-up data call for careful consideration of the durability and consistency of these effects. Potential publication bias was also observed for tDCS on EP. Overall, TMS shows promise for mitigating social cognitive impairments, primarily in EP, but further rigorous investigation is needed to validate its clinical efficacy and long-term benefit. Future research should incorporate large-scale longitudinal studies with neuroimaging and real-world social functioning assessments across disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106380"},"PeriodicalIF":7.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complementary role of egocentric and allocentric spatial navigation tasks for the diagnosis of Alzheimer’s disease: A diagnostic meta-analysis","authors":"Silvia Serino ,&nbsp;Chiara Stramba-Badiale ,&nbsp;Giulia Magni ,&nbsp;Andrea Castegnaro ,&nbsp;Giuseppe Riva ,&nbsp;Cosimo Tuena","doi":"10.1016/j.neubiorev.2025.106379","DOIUrl":"10.1016/j.neubiorev.2025.106379","url":null,"abstract":"<div><div>Spatial navigation impairments represent one of the earliest cognitive changes in patients suffering from Alzheimer’s disease (AD), with their underlying neural circuits overlapping regions affected by AD neuropathology. Despite substantial evidence suggesting different navigational impairments across the AD continuum, the diagnostic utility of specific spatial strategies as cognitive markers remains poorly investigated. This diagnostic meta-analysis aimed to systematically evaluate the sensitivity and specificity of egocentric, allocentric, and frame-switching navigation deficits in distinguishing individuals with AD from cognitively healthy controls. First, we carried out a systematic search to identify studies assessing spatial navigation across the AD continuum, compared to cognitively healthy controls or non-AD dementias. Nineteen studies, comprising 1884 participants, were included. Then, meta-analyses quantified diagnostic accuracy (sensitivity, specificity, diagnostic odds ratios) of spatial navigation tasks. Results revealed complementary diagnostic profiles across spatial strategies, supporting their complementary use for AD detection. Allocentric tasks demonstrated balanced diagnostic performance, correctly identifying 84 % of AD cases while accurately classifying 83 % of cognitively healthy individuals. Frame-switching tasks provided high AD detection (84 % sensitivity) but reduced specificity (66 %), making them valuable for excluding AD but less reliable for confirming it. Combined egocentric-allocentric tasks achieved the highest specificity (94 %), while egocentric tasks showed good specificity (81 %) but limited sensitivity (72 %), suggesting that egocentric abilities remain preserved until advanced disease stages. Taken together, these findings suggest that a strategic approach to spatial navigation assessment is crucial for AD detection.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106379"},"PeriodicalIF":7.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-level prevention of severe mental disorders","authors":"Dominic Oliver ,&nbsp;Jae Il Shin ,&nbsp;Paolo Fusar-Poli","doi":"10.1016/j.neubiorev.2025.106378","DOIUrl":"10.1016/j.neubiorev.2025.106378","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106378"},"PeriodicalIF":7.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calendar calculation: A systematic review of 100 years of research","authors":"Jade Desrosiers ,&nbsp;David Gagnon ,&nbsp;Alexia Ostrolenk ,&nbsp;Alice Boutros ,&nbsp;Boris C. Bernhardt ,&nbsp;Valérie Courchesne ,&nbsp;Laurent Mottron","doi":"10.1016/j.neubiorev.2025.106376","DOIUrl":"10.1016/j.neubiorev.2025.106376","url":null,"abstract":"<div><div>Calendar calculation is the ability to answer rapidly to questions such as \"What day of the week was May 12, 1978?\" or \"For which years is February 15 a Monday?\" This ability is mastered by some \"savant\" autistic people with a surprising level of speed and accuracy. The quasi-specificity of calendar calculation in autism justifies its importance for understanding autistic information processing and learning mechanisms and is informative of certain extreme possibilities of human cognition. A registered (PROSPERO: CRD42021254855) systematic review was conducted using PRISMA guidelines, generating 76 articles (1920–2023) documenting 105 calculators (95 M). We examine: the clinical characteristics of calculators, their cognitive performances, the development and the behavioral correlates to the ability, the empirical findings on calendar calculation, as well as the overall available brain imaging results during calendar tasks. Our findings indicate that calendar calculation is associated with autism and is typically acquired implicitly and in an autodidactic manner, often during school age. Participants tend to demonstrate superior cognitive abilities in their area of interest compared to other domains. When assessed using standardized tools, their performance generally falls within the low full-scale IQ range. 49.5 % had a total calculation range under 100 years. Distance and priming effect were not consistently found showing performance variability. Brain imaging results highlighted three different neural networks that were activated during calendar tasks: memory, visual and arithmetic. This knowledge enables us to establish the common characteristics of calendar calculators and identify gaps in knowledge related to the acquisition of calendar calculation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106376"},"PeriodicalIF":7.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nest-building behavior in laboratory mice: Multifunctional roles and neural mechanisms","authors":"Natsuki Tagawa ,&nbsp;Yousuke Tsuneoka ,&nbsp;Hiromasa Funato","doi":"10.1016/j.neubiorev.2025.106377","DOIUrl":"10.1016/j.neubiorev.2025.106377","url":null,"abstract":"<div><div>Nest-building is a multifunctional and evolutionarily conserved behavior across vertebrate species, serving critical roles in rest, thermoregulation, and offspring care. In laboratory mice, nest-building occurs spontaneously under standard housing conditions and provides an ethologically relevant window into innate behavior modulated by internal state and environmental context. Although nest-building is regarded as an innate behavior, emerging evidence demonstrates its plasticity: it is shaped by experience, hormonal state, ambient temperature, and sleep pressure. Moreover, nest-building is sensitive to strain differences, aging, stress, and neurological disorders, and may serve as a robust behavioral readout for cognitive, affective, and sensorimotor function. It may also provide a valuable indicator of general health and welfare in laboratory mice. We delineate four primary contexts for nest-building—pre-sleep, thermoregulatory, parental, and preparatory during pregnancy, and describe how distinct neural substrates involving the cerebral cortex, hypothalamus, and brain stem, are differentially engaged in each context. This review synthesizes current knowledge on the ethology, physiology, and neural circuits underlying nest-building behavior in laboratory mice.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106377"},"PeriodicalIF":7.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effort and boredom shape our experience of time","authors":"Wanja Wolff ,&nbsp;Sena Özay-Otgonbayar ,&nbsp;James Danckert ,&nbsp;Maik Bieleke ,&nbsp;Corinna S. Martarelli","doi":"10.1016/j.neubiorev.2025.106375","DOIUrl":"10.1016/j.neubiorev.2025.106375","url":null,"abstract":"<div><div>Situations change over time, and so does our experience of them. For example, a task may initially feel engaging but can, over time, become monotonous and boring. Similarly, as processing demands increase or one’s momentary capabilities decline, the same task can feel more or less effortful. The dynamics of these task-induced sensations matter because boredom and perceived effort shape behavior by driving optimization of resource utilization. Time is among the most fundamental resources to which people tend to be acutely sensitive across contexts. Here, we propose that the sensations of boredom and effort influence how the passing of time is experienced. Specifically, both states are linked to changes in interoception—the perception of internal bodily signals—which is known to play a key role in time perception. This proposal offers a framework for understanding how fundamental regulatory sensations, such as boredom and effort, shape temporal experience through interoceptive mechanisms. We highlight the insular cortex as a potential hub mediating the effects of interoceptive signals on time perception, integrating feelings of boredom and effort, and their influence on the experience of time.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106375"},"PeriodicalIF":7.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic review","authors":"Dimitri Fiani ,&nbsp;Sana Chahine ,&nbsp;Mira Zaboube ,&nbsp;Marco Solmi ,&nbsp;Jacquelyn M. Powers ,&nbsp;Chadi Calarge","doi":"10.1016/j.neubiorev.2025.106372","DOIUrl":"10.1016/j.neubiorev.2025.106372","url":null,"abstract":"<div><div>Iron plays a key role in brain functions like energy metabolism and neurotransmitter synthesis. Yet, iron deficiency (ID) is the most common nutritional deficiency worldwide. Children, adolescents, and menstruating adults are particularly at risk. Even in the absence of anemia, ID can be associated with fatigue, reduced quality of life, and worsened symptoms of depression, anxiety, and ADHD. This systematic review and meta-analysis examined the impact of iron supplementation on psychiatric and cognitive outcomes in non-anemic children, adolescents, and menstruating adults. PubMed and Scopus searches identified randomized placebo-controlled trials (RCTs) and pre-post studies involving iron supplementation in non-anemic children and adolescents (ages 5–17 years) and menstruating adults. Studies of similar designs and outcomes were pooled for random-effects meta-analyses. Eighteen studies (12 RCTs, six pre-post) involving 1408 participants, including 1176 menstruating adults (mean age 34.6 ± 9.5 years) and 204 children and adolescents (mean age 13.9 ± 1.4 years, 56 % female), were identified, and sixteen were meta-analyzed. In RCTs, supplementation improved symptoms of anxiety (d = 0.34), fatigue (d = 0.34), physical well-being (d = 0.42), cognitive intelligence (d = 0.46), and short-term memory (d = 0.53) but not attention or depression. Pre-post studies showed improvements in depression (d = 0.93), fatigue (d = 1.01), and overall psychiatric symptoms (d = 1.13). Subgroup analyses confirmed consistent results for ID-only groups, youth, and menstruating adults, though supplementation effects were absent when excluding ID participants. This suggests that, before anemia emerges, ID may impact brain function, potentially requiring identification and treatment.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106372"},"PeriodicalIF":7.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental endocrine disrupting chemicals: Disruptors of central and peripheral clock systems","authors":"Bingcheng Cai ,&nbsp;Qi Sun ,&nbsp;Siyao Li ,&nbsp;Yuanyuan Xu ,&nbsp;Yi Wang","doi":"10.1016/j.neubiorev.2025.106370","DOIUrl":"10.1016/j.neubiorev.2025.106370","url":null,"abstract":"<div><div>The essential role of circadian rhythms in various physiological processes has gained increasing recognition. Their disruption leads to abnormalities in tissue and organ function, as well as the development of diseases. Environmental endocrine disrupting chemicals (EDCs), ubiquitous pollutants in the environment, are well known to enter the human body and greatly affect its homeostasis. Growing attention is being directed towards the impact of EDCs on circadian rhythms, potentially resulting in a succession of serious consequences. Therefore, in this review, we focused on the impact of EDCs on the central clock system, highlighting their potential to disrupt circadian rhythms and examining the underlying mechanisms. Furthermore, we also summarized current evidence showing that EDCs interfere with the peripheral clock systems, impairing key physiological functions, such as hepatic energy metabolism, reproductive function and more. Another topic of this review was to provide insights into recent findings from pioneering research that may shed light on the future discussion about the influences of the central clock system on the peripheral rhythms in the presence of EDCs. Summarizing the emerging findings on the effects of EDC exposure on both central and peripheral clock systems will deepen our understanding of how EDC exposure influences human health and the underlying mechanisms involved.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106370"},"PeriodicalIF":7.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}