Neuroscience and Biobehavioral Reviews最新文献

{"title":"Alterations in resting-state EEG functional connectivity in patients with major depressive disorder receiving electroconvulsive therapy: A systematic review","authors":"Sarah Ulrich ,&nbsp;Else Schneider ,&nbsp;Gunnar Deuring ,&nbsp;Saskia Erni ,&nbsp;Magdalena Ridder ,&nbsp;Jan Sarlon ,&nbsp;Annette B. Brühl","doi":"10.1016/j.neubiorev.2025.106017","DOIUrl":"10.1016/j.neubiorev.2025.106017","url":null,"abstract":"<div><div>Electroconvulsive therapy (ECT) is highly efficacious for the treatment of major depressive disorder (MDD), but its mechanisms still require clarification. Even though depression is associated with alterations in functional connectivity (FC), EEG studies investigating effects of ECT on FC have not been systematically reviewed. Understanding these effects may help to identify the role of functional brain circuits in depression and its remission. This systematic review aimed to synthesize EEG studies investigating FC changes in ECT-treated patients with depression. A systematic literature search was conducted following PRISMA guidelines. Peer-reviewed studies on pre-to post-ECT resting-state EEG FC changes in adult patients with MDD were included. Three of 143 studies were included, of which two reported reduced FC in the alpha and beta frequency bands and increased theta band FC in patients with ECT-treated MDD. Changes in alpha band FC were associated with treatment outcomes. Patients with MDD exhibit increased electrophysiological resting-state alpha band FC, particularly frontally, compared with healthy subjects. Thus, ECT-induced decrease might indicate a trend toward normalization of oscillatory brain rhythms. As brain oscillations have been proposed to be involved in neuronal synchronization, which is important for communication between networks, the potential restoration in patients with depression and the association of FC changes with clinical improvement may indicate a potential mechanism of action of ECT. Understanding ECT’s underlying mechanisms might ultimately enable treatment optimization, thus enhancing patient care. However, the number of studies is limited, with low-to-moderate EEG study quality, small sample sizes, and different electrophysiological FC measures.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106017"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social cognition in autism and ADHD","authors":"Sven Bölte","doi":"10.1016/j.neubiorev.2025.106022","DOIUrl":"10.1016/j.neubiorev.2025.106022","url":null,"abstract":"<div><div>Social cognition is a crucial capacity for social functioning. The last decades have seen a plethora of social cognition research in neurodevelopmental conditions, foremost autism and, to a lesser extent, ADHD, both characterized by social challenges. Social cognition is a multifaceted construct comprising various overlapping subdomains, such as Theory of Mind/mentalizing, emotion recognition, and social perception. Mechanisms underpinning social cognition are complex, including implicit and explicit, cognitive and affective, and hyper- and hypo-social information processing. This review explores the intricacies of social cognition in the context of autism and ADHD. Research indicates altered performance on social cognition tests in autism, compared to neurotypical groups, with social cognition alterations having a small but robust effect on the defining features of autism. The nature of such alterations in autism appears primarily in relation to implicit processing. ADHD groups show intermediate social cognition performance, appearing to be influenced by executive function difficulties. Social cognition varies with intellectual and verbal abilities and seems to improve with age in autism and ADHD. Social skills interventions in autism, and stimulant medication in ADHD have been shown to improve social cognition test performance, while mentalizing training effects in autism are less conclusive. A limitation of the field is that social cognition constructs and tests are not well delineated. Further, most research has been embedded in a nativist approach rather than a constructivist approach. The former has been questioned for ignoring environmental contributions, especially the dimension of mutual miscommunication between neurodivergent and neurotypical individuals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106022"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plexins: Navigating through the neural regulation and brain pathology","authors":"Ariba Khan ,&nbsp;Poonam Sharma ,&nbsp;Sarthak Dahiya ,&nbsp;Bhupesh Sharma","doi":"10.1016/j.neubiorev.2024.105999","DOIUrl":"10.1016/j.neubiorev.2024.105999","url":null,"abstract":"<div><div>Plexins are a family of transmembrane receptors known for their diverse roles in neural development, axon guidance, neuronal migration, synaptogenesis, and circuit formation. Semaphorins are a class of secreted and membrane proteins that act as primary ligands for plexin receptors. Semaphorins play a crucial role in central nervous system (CNS) development by regulating processes such as axonal growth, neuronal positioning, and synaptic connectivity. Various types of semaphorins like sema3A, sema4A, sema4C, sema4D, and many more have a crucial role in developing brain diseases. Likewise, various evidence suggests that plexin receptors are of four types: plexin A, plexin B, plexin C, and plexin D. Plexins have emerged as crucial regulators of neurogenesis and neuronal development and connectivity. When bound to semaphorins, these receptors trigger two major networking cascades, namely Rho and Ras GTPase networks. Dysregulation of plexin networking has been implicated in a myriad of brain disorders, including autism spectrum disorder (ASD), Schizophrenia, Alzheimer's disease (AD), Parkinson's disease (PD), and many more. This review synthesizes findings from molecular, cellular, and animal model studies to elucidate the mechanisms by which plexins contribute to the pathogenesis of various brain diseases.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105999"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-to-individual generalizability and individual-level inferences in cognitive neuroscience","authors":"Matthew Mattoni ,&nbsp;Aaron J. Fisher ,&nbsp;Kathleen M. Gates ,&nbsp;Jason Chein ,&nbsp;Thomas M. Olino","doi":"10.1016/j.neubiorev.2025.106024","DOIUrl":"10.1016/j.neubiorev.2025.106024","url":null,"abstract":"<div><div>Much of cognitive neuroscience research is focused on group-averages and interindividual brain-behavior associations. However, many theories core to the goal of cognitive neuroscience, such as hypothesized neural mechanisms for a behavior, are inherently based on intraindividual processes. To accommodate this mismatch between study design and theory, research frequently relies on an implicit assumption that group-level, between-person inferences extend to individual-level, within-person processes. The assumption of group-to-individual generalizability, formally referred to as ergodicity, requires that a process be both homogenous within a population and stationary within individuals over time. Our goal in this review is to assess this assumption and provide an accessible introduction to idiographic science (study of the individual) for the cognitive neuroscientist, ultimately laying a foundation for increased focus on the study of intraindividual processes. We first review the history of idiographic science in psychology to connect this longstanding literature with recent individual-level research goals in cognitive neuroscience. We then consider two requirements of group-to-individual generalizability, pattern homogeneity and stationarity, and suggest that most processes in cognitive neuroscience do not meet these assumptions. Consequently, interindividual findings are inappropriate for the intraindividual inferences that many theories are based on. To address this challenge, we suggest precision imaging as an ideal path forward for intraindividual study and present a research framework for complementary interindividual and intraindividual study.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106024"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear and safety learning in anxiety- and stress-related disorders: An updated meta-analysis","authors":"Franziska M. Kausche ,&nbsp;Hannes P. Carsten ,&nbsp;Kim M. Sobania ,&nbsp;Anja Riesel","doi":"10.1016/j.neubiorev.2024.105983","DOIUrl":"10.1016/j.neubiorev.2024.105983","url":null,"abstract":"<div><div>Fear learning processes are believed to play a crucial role in the development and maintenance of anxiety and stress-related disorders. To integrate results across different studies, we conducted a systematic meta-analysis following PRISMA guidelines to examine differences in fear conditioning during fear acquisition, extinction, and extinction recall between individuals with anxiety-related or stress-related disorders and healthy participants. This analysis updates the work of Duits et al. (2015) while also refining distinctions between physiological and behavioral outcomes and examining extinction recall. Our meta-analysis encompasses 77 studies published from 1986 to 2022, involving 2052 patients with anxiety disorders, obsessive-compulsive disorder, or post-traumatic stress disorder, and 3258 healthy controls. The results indicate significant differences in fear acquisition, extinction, and recall between the two groups. Specifically, during acquisition patients exhibited heightened physiological and behavioral responses to the CS- and reported increased affect ratings for the CS+ . During extinction and extinction recall, patients continue to show heightened threat expectancy and negative affect ratings towards the CS- and increased affect ratings towards the CS+ . No differences were found in CS+ /CS- differentiation between groups. These findings imply that individuals with anxiety and stress-related disorders may exhibit amplified responses to safety cues and stronger reactions to threat cues during fear conditioning, lasting through extinction and extinction recall. These changes may lead to increased sensitivity in detecting fear and slower extinction process, resulting in more enduring anxiety responses. We discuss these results in the context of existing literature on fear and safety learning and consider potential underlying mechanisms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105983"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could sleep be a brain/cognitive/neural reserve-builder factor? A systematic review on the cognitive effects of sleep modulation in animal models","authors":"Francesca Balsamo ,&nbsp;Debora Meneo ,&nbsp;Erica Berretta ,&nbsp;Chiara Baglioni ,&nbsp;Francesca Gelfo","doi":"10.1016/j.neubiorev.2025.106015","DOIUrl":"10.1016/j.neubiorev.2025.106015","url":null,"abstract":"<div><div>The brain/cognitive/neural reserve concept suggests that lifelong experiences, from early life through adulthood, make the brain more resilient to neuronal damage. Modifiable lifestyle factors, such as sleep, can support the development and enhance such a reserve, helping to counteract age- or disease-related brain changes and their impact on cognition. Sleep plays a crucial role in cognitive functioning, and disruptions or disorders may increase neurodegenerative risks. This systematic review aims to explore how functional and disturbed sleep impacts cognitive functions and neuromorphological mechanisms in rodents, aiming to better understand its role in brain/cognitive/neural reserve development. This systematic review, registered on PROSPERO (ID: CRD42023423901) and conducted according to PRISMA-P guidelines, searched PubMed, Scopus, Web of Science, and Embase databases for studies up to June 2022, with terms related to sleep, rodents, and cognitive functions. Of the 28,666 articles identified, 142 met the inclusion criteria. Main results showed significant cognitive decline after sleep deprivation, especially in memory performance. These findings supports the importance of sleep as a critical factor in modulating brain/cognitive/neural reserve.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106015"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles governing the effects of sensory loss on human abilities: An integrative review","authors":"Andrew J. Kolarik ,&nbsp;Brian C.J. Moore","doi":"10.1016/j.neubiorev.2024.105986","DOIUrl":"10.1016/j.neubiorev.2024.105986","url":null,"abstract":"<div><div>Blindness or deafness can significantly influence sensory abilities in intact modalities, affecting communication, orientation and navigation. Explanations for why certain abilities are enhanced and others degraded include: crossmodal cortical reorganization enhances abilities by providing additional neural processing resources; and sensory processing is impaired for tasks where calibration from the normally intact sense is required for good performance. However, these explanations are often specific to tasks or modalities, not accounting for why task-dependent enhancement or degradation are observed. This paper investigates whether sensory systems operate according to a theoretical framework comprising seven general principles (the perceptual restructuring hypothesis) spanning the various modalities. These principles predict whether an ability will be enhanced or degraded following sensory loss. Evidence from a wide range of studies is discussed, to assess the validity of the principles across different combinations of impaired sensory modalities (deafness or blindness) and intact modalities (vision, audition, touch, olfaction). It is concluded that sensory systems do operate broadly according to the principles of the framework, but with some exceptions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105986"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From feeling chilly to burning up: How thermal signals shape the physiological state of the body and impact physical, emotional, and social well-being","authors":"Alisha Vabba ,&nbsp;Marina Scattolin ,&nbsp;Giuseppina Porciello ,&nbsp;Maria Serena Panasiti ,&nbsp;Salvatore Maria Aglioti","doi":"10.1016/j.neubiorev.2024.105992","DOIUrl":"10.1016/j.neubiorev.2024.105992","url":null,"abstract":"<div><div>This review examines the role of thermal interoception—awareness of body temperature—in shaping physiological states and its impact on physical, emotional, and social well-being. We describe the neural pathways and mechanisms involved in thermal processing and environmental heat exchange and how thermal interoception influences both autonomic and behavioral responses, contributing to survival and homeostasis. Additionally, the review highlights the significance of thermal signals and thermoregulation in determining higher-order cognitive and emotional functions, such as regulating sleep patterns and activity levels, monitoring physical well-being, regulating emotions, and even social interactions. We describe the existing instruments for assessing body temperature and thermal awareness and call for further research to investigate the role of thermal interoception in emotional and social domains. We also discuss potential therapeutic applications, particularly in the context of psychosomatic and neurological disorders characterized by emotional dysregulation, disrupted sleep and mood patterns, social difficulties, and alterations in self-consciousness.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105992"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relations between psychosis and emotion regulation in daily life: A systematic review and meta-analyses of studies using experience sampling methods","authors":"Catherine Bortolon ,&nbsp;Carla Nardelli","doi":"10.1016/j.neubiorev.2025.106004","DOIUrl":"10.1016/j.neubiorev.2025.106004","url":null,"abstract":"<div><div>Research has shown that heightened emotionality often precedes psychotic experiences. Understanding how individuals cope with these emotions is crucial for psychosis. While prior studies on emotion regulation (ER) and psychosis have mainly relied on self-report questionnaires, recent research has increasingly utilised daily life methods. This systematic review and meta-analysis seek to examine the relationship between daily ER and psychotic experiences. In total, 15 studies were included in the meta-analysis (21 in the systematic review). The results of Experience Sampling Methods (ESM) studies indicated that ER strategies of avoidance, reappraisal, repetitive thinking, and emotional suppression are not associated with psychotic experiences in daily life. The effect was not moderated by type of sample (clinical vs non-clinical), symptom (hallucination vs delusions), relation (contemporaneous vs perspective), or other methodological variables. Acceptance was found to be negatively associated with psychotic experiences, but the effect was small. These results indicate that ER in daily life might not impact directly on psychotic experiences. The results are discussed in light of conceptual and methodological limitations in the field.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106004"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind closed eyes: Understanding nightmares in children and adolescents with autism spectrum disorder – A systematic review","authors":"Elisa Pellegrini ,&nbsp;Serena Scarpelli ,&nbsp;Valentina Alfonsi ,&nbsp;Maurizio Gorgoni ,&nbsp;Mariella Pazzaglia ,&nbsp;Luigi De Gennaro","doi":"10.1016/j.neubiorev.2025.106012","DOIUrl":"10.1016/j.neubiorev.2025.106012","url":null,"abstract":"<div><h3>Introduction</h3><div>Brain and sleep development in childhood shapes emotional and cognitive growth, including the ability to recall dreams. In line with the continuity hypothesis of dreaming, several findings suggest a link between clinical symptoms and nightmare frequency. Sleep disorders and anxiety are among the most frequently co-occurring conditions in children and adolescents with autism spectrum disorder (ASD). However, their impact on nightmares has not yet been systematically explored.</div><div>This review aims to address this research gap by investigating nightmares in autism and their influence on clinical symptoms and cognitive functioning.</div></div><div><h3>Methods</h3><div>The literature was searched utilizing the databases PubMed, PsycINFO, Web of Science, and Scopus, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The included studies were assessed for methodological quality.</div></div><div><h3>Results</h3><div>Twenty-nine papers were reviewed. The prevalence of nightmares occurring very frequently was below 5 %, with no significant difference in nightmare prevalence between children with ASD and their healthy peers. Furthermore, several findings reported a relationship between nightmares and other sleep disturbances among individuals with ASD.</div></div><div><h3>Discussion</h3><div>The study of dreaming in ASD may provide valuable insights into the disorder. Although comorbid sleep disorders can influence nightmare frequency, the results of this review suggest that nightmares may not represent a distinctive feature of ASD. However, poor communication and introspection skills may explain the difficulties in reporting dream experiences.</div><div>Given the preliminary nature of current research on nightmares in ASD, further studies are essential to overcome existing limitations and deepen our understanding.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106012"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}