Neuroscience and Biobehavioral Reviews最新文献_第5页

A restarted life: Resetting microglia innate immune memory 重新开始的生命：重置小胶质细胞先天免疫记忆

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-14 DOI: 10.1016/j.neubiorev.2025.106206

Fangyuan Cheng , Bo Yan , Fanglian Chen , Ping Lei

引用次数: 0

Linguistic and emotional prosody: A systematic review and ALE meta-analysis 语言与情感韵律：系统回顾与ALE元分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-14 DOI: 10.1016/j.neubiorev.2025.106210

Charalambos Themistocleous

{"title":"Linguistic and emotional prosody: A systematic review and ALE meta-analysis","authors":"Charalambos Themistocleous","doi":"10.1016/j.neubiorev.2025.106210","DOIUrl":"10.1016/j.neubiorev.2025.106210","url":null,"abstract":"<div><div>Prosody is a cover term referring to the melodic aspects of speech, with linguistic and affective (a.k.a. emotional) meanings. This review provides an overview of linguistic and affective prosody, evaluating two hypotheses on healthy individuals' linguistic and affective prosody. The first hypothesizes that the biological nature of affective prosody triggers activations unrelated to language (biological hypothesis), and the second that the aspects of affective prosody have been grammaticalized, i.e., incorporated into the language (linguistic hypothesis). We employed a systematic ALE metanalytic approach to identify neural correlates of prosody from the literature. Specifically, we assessed papers that report brain coordinates from healthy individuals selected using systematic research from academic databases, such as PubMed (NLM), Scopus, and Web of Science. We found that affective and linguistic prosody activate bilateral frontotemporal regions, like the Superior Temporal Gyrus (STG). A key difference is that affective prosody involves subcortical structures like the amygdala, and linguistic prosody activates linguistic areas and brain areas of social cognition and engagement. The shared activations, therefore, suggest that linguistic and affective meanings are combined, involving shared underlying brain connectivity mechanisms and acoustic manifestations. We suggest that the traditional distinction between linguistic and affective prosody may be overly rigid. Much like speech, lexicon, and grammar—domains that convey affective, social, and linguistic meanings without explicitly reflecting separate categories—prosody, too, functions as a system interfacing with affective, social, and linguistic domains. We conclude by proposing a novel blending hypothesis: prosody should be viewed as an integrated system that serves both affective and linguistic functions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106210"},"PeriodicalIF":7.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal cannabinoid exposure and the developing brain: Evidence of lasting consequences in preclinical rodent models 产前大麻素暴露和发育中的大脑：临床前啮齿动物模型持久后果的证据。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-13 DOI: 10.1016/j.neubiorev.2025.106207

Bryan W. Jenkins , Catherine F. Moore , Lauren L. Jantzie , Elise M. Weerts

{"title":"Prenatal cannabinoid exposure and the developing brain: Evidence of lasting consequences in preclinical rodent models","authors":"Bryan W. Jenkins , Catherine F. Moore , Lauren L. Jantzie , Elise M. Weerts","doi":"10.1016/j.neubiorev.2025.106207","DOIUrl":"10.1016/j.neubiorev.2025.106207","url":null,"abstract":"<div><div>Cannabis use by people who are pregnant is increasing. Understanding how prenatal cannabinoid exposure (PCE) affects infants and children is of high public health significance. Epidemiological studies have associated PCE with cognitive symptoms, including impaired learning, memory, attention, and executive control, and affective symptoms, including anxiety, emotional dysregulation, and social impairments, in children, adolescents, and young adults. PCE is also associated with neurobiological changes including decreased corticolimbic white matter and functional connectivity; however, the underlying mechanisms for these persisting effects remain unknown. Rodent models are essential for uncovering the effects of PCE on the developing brain. This review summarizes rodent studies focused on the cognitive and affective behavioral and neurobiological outcomes of PCE. Rodent studies have reported cognitive deficits, including impaired learning, memory, attention, and executive control, and affect-related impairments, including anxiety-like behavior, altered stress coping, social impairments, and anhedonia-like behavior, in adolescent and adult offspring. Studies have also demonstrated that PCE affects several underlying neurotransmitter systems, producing dopamine hyperactivity, glutamate and serotonin hypoactivity, and dysregulating GABA and opioid signaling. Evidence further suggests a marked difference in outcomes between males and females, with males being more susceptible to the enduring effects of PCE. However, studies that investigate female-specific outcomes or sex as a biological variable are scarce. Altogether, rodent studies provide corroborating evidence that PCE produces lasting cognitive and affective impairments underpinned by altered neurobiological mechanisms. Research is critically needed to improve our understanding of the risks associated with cannabis use during pregnancy and effects across the lifespan.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106207"},"PeriodicalIF":7.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demyelination in psychiatric and neurological disorders: Mechanisms, clinical impact, and novel therapeutic strategies 精神和神经疾病的脱髓鞘：机制、临床影响和新的治疗策略。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-12 DOI: 10.1016/j.neubiorev.2025.106209

Rumi Murayama , Yi Cai , Hiroyuki Nakamura , Kenji Hashimoto

{"title":"Demyelination in psychiatric and neurological disorders: Mechanisms, clinical impact, and novel therapeutic strategies","authors":"Rumi Murayama , Yi Cai , Hiroyuki Nakamura , Kenji Hashimoto","doi":"10.1016/j.neubiorev.2025.106209","DOIUrl":"10.1016/j.neubiorev.2025.106209","url":null,"abstract":"<div><div>Demyelination, defined as the loss of myelin sheaths around neuronal axons, is increasingly recognized as a key factor in a broad range of psychiatric and neurological disorders, including schizophrenia, major depressive disorder, bipolar disorder, post-traumatic stress disorder, autism spectrum disorder, substance use disorders, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. This review investigates the core mechanisms driving demyelination, its clinical impact, and emerging therapeutic strategies aimed at maintaining or restoring myelin integrity. Disruption of myelin impairs crucial neural communication pathways, resulting in cognitive, motor, and behavioral deficits that substantially reduce quality of life and create significant economic and social challenges. Key contributors to demyelination include genetic predisposition, environmental triggers, immune dysregulation, neuroinflammation, and alterations in the gut–brain axis mediated by the vagus nerve. Promising therapies include sphingosine 1-phosphate receptor modulators and muscarinic acetylcholine receptor antagonists, both of which diminish immune-related myelin damage and may enhance neuroprotection. In addition, the novel antidepressant arketamine appears to boost myelination through transforming growth factor-β1 signaling pathways. Approaches targeting the gut–brain axis, such as noninvasive transcutaneous auricular vagus nerve stimulation and fecal microbiota transplantation, may also help reduce inflammation and support myelin repair. Future research should center on clarifying the precise molecular mechanisms of demyelination, developing targeted therapies, and leveraging advanced neuroimaging for earlier detection and personalized treatment. By combining immunomodulatory and neuroprotective strategies, there is potential to significantly improve outcomes for individuals affected by demyelinating psychiatric and neurological disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106209"},"PeriodicalIF":7.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between callous unemotional traits cognitive control performance and reward sensitivity in youths with conduct problems – A systematic review and meta-analysis 行为问题青少年冷酷无情特征、认知控制表现与奖励敏感性的关系——系统回顾与荟萃分析

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-12 DOI: 10.1016/j.neubiorev.2025.106211

Ursula Pauli-Pott , Lisa Sens , Christina Pott

{"title":"Association between callous unemotional traits cognitive control performance and reward sensitivity in youths with conduct problems – A systematic review and meta-analysis","authors":"Ursula Pauli-Pott , Lisa Sens , Christina Pott","doi":"10.1016/j.neubiorev.2025.106211","DOIUrl":"10.1016/j.neubiorev.2025.106211","url":null,"abstract":"<div><div>Poor cognitive control (CC, i.e., low-level executive functions) capacity and increased reward sensitivity (RS) represent core traits and meaningful predictors in developing externalizing disorders. The inclusion of the limited-prosocial-emotions specifier (also termed callous-unemotional (CU) traits) into the DSM-5 diagnostic criteria for conduct disorders led to an increase in research on associations of CU traits with CC and RS. The review quantitatively summarizes this research and analyzes hypothesized moderator effects by target population (with conduct problems (CP); healthy community) and the socioeconomic status of the family. We focused on studies that assessed CC or RS using neuropsychological tasks. Literature search yielded 22 eligible studies (providing k = 27 observed effects). Regarding the link between CU traits and CC, the hypothesized moderator effect of population proved statistically significant. Using a random-effects model, the weighted mean effect size for the CU-CC association in youths with CP was r = .112 (CI<sub>95</sub>: 0.00; 0.22, k = 10, p < .05). The result was robust against exclusion of an outlier (r = .138, CI<sub>95</sub>: 0.04; 0.24, k = 9, p < .01). Among youths with CP, high CU traits related to less impaired CC performance, and vice versa. Regarding the CU-RS association, the moderator effect by population was not statistically significant. The weighted mean effect size for the CU-RS link in youths with CP reached significance after the exclusion of an outlier (r = .164, CI<sub>95</sub>: 0.075; 0.252, k = 6, p < .001). The positive association between CU traits and CC among youths with CP aligns with models on antisocial behavior and findings from neurophysiological research. The moderator effect of population explains previously mixed findings.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106211"},"PeriodicalIF":7.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of cerebrospinal fluid in autism spectrum disorder – A systematic review 自闭症谱系障碍的脑脊液特征——系统综述

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-10 DOI: 10.1016/j.neubiorev.2025.106202

Vandana Srivastava , Christian O’Reilly

{"title":"Characteristics of cerebrospinal fluid in autism spectrum disorder – A systematic review","authors":"Vandana Srivastava , Christian O’Reilly","doi":"10.1016/j.neubiorev.2025.106202","DOIUrl":"10.1016/j.neubiorev.2025.106202","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a range of neurodevelopmental conditions characterized by impaired social interaction, learning, and restricted or repetitive behaviors. The underlying causes of ASD are still debated, but researchers have found many physiological traits like gut problems and impaired immune system to help understand the etiology of ASD. Cerebrospinal fluid (CSF) plays a critical role in maintaining the homeostasis of the neuronal environment and has, therefore, been analyzed in multiple conditions impacting the central nervous system. The study of CSF is crucial to understanding neurological disorders as its composition changes with the disorders, and these changes may indicate various disorder-related physiological mechanisms. For this systematic review, we searched PubMed, Scopus, and Web of Science for studies published between 1977 and 2025 and selected 49 studies after manual screening. We took stock of the evidence supporting the hypothesis that ASD alters the properties and composition of CSF. We systematically report on the different attributes of CSF in the ASD population that could be potential biomarkers and assist in understanding the origins and progression of ASD.</div><div>We found that in CSF, immune markers, proteins, extra-axial CSF, folate, oxytocin, and vasopressin showed changes in ASD compared to the neurotypicals. We observed gaps in the literature due to variations in age and sample size and noted biases related to sex (i.e., samples are predominantly including male participants) and age (i.e., a handful of studies were conducted on adults). Our review highlights the need for more research on CSF in ASD to improve our understanding of this disorder and identify CSF biomarkers.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106202"},"PeriodicalIF":7.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping universal and culturally specific moral brain: An SDM meta-analysis of neural correlates in shame and guilt across East Asian and Western contexts 绘制普遍的和文化特定的道德大脑：东亚和西方背景下羞耻和内疚神经相关的SDM元分析

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-10 DOI: 10.1016/j.neubiorev.2025.106200

Taihan Chen, Yidan Qiu, Runchen Gan, Yanxuan Du, Yihe Zhang, Shuting Lin, Xinrui Li, Ruiwang Huang

{"title":"Mapping universal and culturally specific moral brain: An SDM meta-analysis of neural correlates in shame and guilt across East Asian and Western contexts","authors":"Taihan Chen, Yidan Qiu, Runchen Gan, Yanxuan Du, Yihe Zhang, Shuting Lin, Xinrui Li, Ruiwang Huang","doi":"10.1016/j.neubiorev.2025.106200","DOIUrl":"10.1016/j.neubiorev.2025.106200","url":null,"abstract":"<div><div>Shame and guilt are moral emotions that promote individual interests and maintain social norms. Previous studies suggested that these emotions are universal but that their specific experience and underlying neural mechanisms may be culturally influenced. However, little is known about the cross-cultural neural mechanisms of these emotions, including their commonalities and differences. Understanding these mechanisms may elucidate the evolutionary significance of these emotions and clarify how culture influences them. Therefore, we performed a meta-analysis of 62 neuroimaging studies to identify the neural correlates of shame and guilt across East Asian cultures (EAC) and Western cultures (WC) using seed-based <em>d</em> mapping with permutation of subject images (SDM-PSI). We found that shame and guilt shared brain locations with significant activation in the middle cingulate cortex (MCC) and insula regardless of cultural background. However, we also observed differences in the brain activation patterns between the two cultures. Shame elicited stronger activation in the MCC in EAC than in WC. Guilt elicited stronger activation in areas related to theory of mind, such as the temporal pole and precuneus, in WC than in EAC. These results indicate that, although shame and guilt share similar neural mechanisms, the cultural contexts can modulate the activation patterns of the relevant brain regions. These findings provide insights into the universal and culturally specific neural mechanisms underlying shame and guilt. We hope that this study helps to promote mutual respect among people from different cultures and understand what we have in common as well as how and why we differ.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106200"},"PeriodicalIF":7.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning approaches for classifying major depressive disorder using biological and neuropsychological markers: A meta-analysis 使用生物学和神经心理学标记物对重度抑郁症进行分类的机器学习方法：荟萃分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-10 DOI: 10.1016/j.neubiorev.2025.106201

Lin Zhang , Liwen Jian , Yiming Long , Zhihong Ren , Vince D. Calhoun , Ives Cavalcante Passos , Xinyu Tian , Yuhong Xiang

{"title":"Machine learning approaches for classifying major depressive disorder using biological and neuropsychological markers: A meta-analysis","authors":"Lin Zhang , Liwen Jian , Yiming Long , Zhihong Ren , Vince D. Calhoun , Ives Cavalcante Passos , Xinyu Tian , Yuhong Xiang","doi":"10.1016/j.neubiorev.2025.106201","DOIUrl":"10.1016/j.neubiorev.2025.106201","url":null,"abstract":"<div><div>Traditional diagnostic methods for major depressive disorder (MDD), which rely on subjective assessments, may compromise diagnostic accuracy. In contrast, machine learning models have the potential to classify and diagnose MDD more effectively, reducing the risk of misdiagnosis associated with conventional methods. The aim of this meta-analysis is to evaluate the overall classification accuracy of machine learning models in MDD and examine the effects of machine learning algorithms, biomarkers, diagnostic comparison groups, validation procedures, and participant age on classification performance. As of September 2024, a total of 176 studies were ultimately included in the meta-analysis, encompassing a total of 60,926 participants. A random-effects model was applied to analyze the extracted data, resulting in an overall classification accuracy of 0.825 (95 % CI [0.810; 0.839]). Convolutional neural networks significantly outperformed support vector machines (SVM) when using electroencephalography and magnetoencephalography data. Additionally, SVM demonstrated significantly better performance with functional magnetic resonance imaging data compared to graph neural networks and gaussian process classification. The sample size was negatively correlated to classification accuracy. Furthermore, evidence of publication bias was also detected. Therefore, while this study indicates that machine learning models show high accuracy in distinguishing MDD from healthy controls and other psychiatric disorders, further research is required before these findings can be generalized to large-scale clinical practice.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106201"},"PeriodicalIF":7.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the altruistic brain: An ALE meta-analysis of the functional localization of giving behaviors 解码利他主义大脑：给予行为功能定位的ALE元分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-10 DOI: 10.1016/j.neubiorev.2025.106205

Zhibo Yang, Peng Li

{"title":"Decoding the altruistic brain: An ALE meta-analysis of the functional localization of giving behaviors","authors":"Zhibo Yang, Peng Li","doi":"10.1016/j.neubiorev.2025.106205","DOIUrl":"10.1016/j.neubiorev.2025.106205","url":null,"abstract":"<div><div>Neuroimaging studies on prosocial decision-making frequently employ a costly giving paradigm, whereas there is a lack of consensus on the broader differences underlying various altruistic giving tasks. This study explores the neural substrates of altruistic giving through an ALE meta-analysis of 65 fMRI studies with 2803 participants. Altruistic giving tasks were categorized into Dictator Game (DG), Charitable Donation (CD), and Pain versus Gain (PvsG). The meta-analysis identified consistent activation in core brain regions, including the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), and insula, which are involved in value computation, conflict monitoring, and emotional processing. Task-specific analyses revealed that the DG task activated the right dorsomedial prefrontal cortex (dmPFC) and presupplementary motor area (pre-SMA), indicating cognitive control of fairness. The CD task showed significant activation in the nucleus accumbens (NAcc) and the second visual cortex, reflecting socio-cognitive evaluation based on context and stimuli. The PvsG task uniquely activated the vmPFC and orbitofrontal cortex (OFC), suggesting rapid moral-emotional trade-offs under urgency. These findings indicate that altruistic giving is context-dependent, shaped by specific task demands. Future research should integrate computational modeling with neuroscientific data and explore individual differences and real-world applications.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106205"},"PeriodicalIF":7.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence 变化之窗：回顾记忆再巩固和持久的时间和分子动力学。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-10 DOI: 10.1016/j.neubiorev.2025.106198

Hugo Bayer , Leandro J. Bertoglio , Stephen Maren , Cristina A.J. Stern

{"title":"Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence","authors":"Hugo Bayer , Leandro J. Bertoglio , Stephen Maren , Cristina A.J. Stern","doi":"10.1016/j.neubiorev.2025.106198","DOIUrl":"10.1016/j.neubiorev.2025.106198","url":null,"abstract":"<div><div>Retrieval can bring memories to a labile state, creating a window to modify its content during reconsolidation. Numerous studies have investigated this period to elucidate reconsolidation mechanisms, understand long-term memory persistence, and develop therapeutic strategies for memory-related psychiatric disorders. However, the temporal dynamics of post-retrieval memory processes have been largely overlooked, leading to mixed findings and hindering the development of targeted interventions. This review discusses retrieval-related cellular and molecular events and how they develop in series and parallel across time. Emerging evidence suggests that some mechanisms triggered after fear memory retrieval can influence either reconsolidation or persistence in different time windows. The temporal boundaries of these post-retrieval processes are still unclear. Further research integrating behavioral and molecular approaches to a deeper understanding of reconsolidation and persistence temporal dynamics is essential to address current debates, including which system/pathway offers the most effective therapeutic window of opportunity.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106198"},"PeriodicalIF":7.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0