Neuroscience and Biobehavioral Reviews最新文献

{"title":"Nature's shield – Harnessing green spaces to combat dementia: A global meta-analysis","authors":"Yixin Zhang ,&nbsp;Li Wu ,&nbsp;Wuji Zhao ,&nbsp;Li Zheng ,&nbsp;Li Zuo","doi":"10.1016/j.neubiorev.2025.106360","DOIUrl":"10.1016/j.neubiorev.2025.106360","url":null,"abstract":"<div><div>As global aging populations increase, dementia is one of the fastest-growing global public health challenges across multiple sectors. About 10 % of the population aged 65 years and older are affected by some form of dementia without adequate medical treatment to cure, so finding practical approaches for the prevention, intervention, and care of dementia is urgent. With multiple health benefits, green spaces provide therapeutic functions as nature-based solutions for people with dementia. The meta-analysis and comprehensive review have revealed a beacon of hope through a search of six databases from 2009 to 2024 and the identification of 37 eligible studies. Results showed that urban green spaces, particularly those featuring community gardens, significantly impacted individuals with dementia and the older population. The results, which showed a significant effect size correlation in four key areas: individual ability, social interaction, mental stress, and emotional health, highlight the positive impact of these green spaces. The specific performance of these green spaces is as follows: reduced incidence of dementia (-0.06), improved social participation (0.14), increased physical isolation (0.54), reduced anxiety (-0.28), relieved depression, relieved mental disorders (-0.32), calmed agitation (-0.06), increased positive emotions (0.10), reduced sadness and anger, improved quality of life, enhanced cognitive function (0.52), and improved sleep. Finally, the mechanisms of green spaces' influence on the health of people living with dementia, including the perception of green spaces contact, intermediary pathway, and health effects, provide a compelling argument for implementing urban green spaces coupled with ecosystem services as a pragmatic approach to improving the mental health and overall well-being of older people and those with dementia. Such initiatives not only contribute to the prevention of dementia by addressing multiple, simultaneous alterations to avert and combat it but also align with the broader goals of achieving sustainable development.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106360"},"PeriodicalIF":7.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome and mitochondrial crosstalk in Schizophrenia, a mental disability: Emerging mechanisms and therapeutic targets","authors":"Vajagthali Mohammed ,&nbsp;Muthumareeswaran Muthuramamoorthy ,&nbsp;M. Valan Arasu ,&nbsp;Jesu Arockiaraj","doi":"10.1016/j.neubiorev.2025.106371","DOIUrl":"10.1016/j.neubiorev.2025.106371","url":null,"abstract":"<div><div>Gut-mitochondria axis is an emerging paradigm in understanding the pathophysiology of complex neuropsychiatric disorders such as Schizophrenia (SCZ). This bidirectional communication network connects the gastrointestinal microbiota with mitochondrial function and brain health, offering novel insights into disease onset and progression. SCZ, characterized by hallucinations, delusions, cognitive impairments, and social withdrawal, has traditionally been attributed to genetic and neurochemical imbalances. However, growing evidence highlights the role of systemic factors specifically, gut microbiome dysbiosis and mitochondrial dysfunction as key contributors to its etiology. Gut dysbiosis in SCZ involves a decrease in health-promoting microbiota such as <em>Faecalibacterium</em> and <em>Roseburia</em>, as well as an increase in pro-inflammatory taxa such as <em>Proteobacteria</em>. The dysbiosis leads to elevated levels of microbial metabolites like lipopolysaccharide (LPS) and trimethylamine-N-oxide (TMAO), which can overcome the intestinal barrier, induce systemic inflammation, and activate toll-like receptors and microglia which drive neuroinflammatory cascades. Simultaneously, mitochondrial dysfunction marked by impaired oxidative phosphorylation, ATP depletion, reactive oxygen species (ROS) accumulation, and mtDNA mutations exacerbates synaptic deficits and neurotransmitter dysregulation, particularly in dopaminergic, glutamatergic, and GABAergic systems. In this review we summarize what we currently know about the gut-mitochondria axis as being core to SCZ pathogenesis via molecular biology, neuroimmunology, and the microbiome. We also identify potential diagnostic biomarkers and therapeutic options that could include the use of probiotics, prebiotics, mitochondrial-targeted antioxidants, and dietary modifications in restoring gut and mitochondrial homeostasis. If the gut-mitochondria axis is linked, such programs may provide improved personalization, efficacy, and mechanistic precision, for future treatments of SCZ.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106371"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The myth of optimality in human movement science","authors":"Madhur Mangalam","doi":"10.1016/j.neubiorev.2025.106352","DOIUrl":"10.1016/j.neubiorev.2025.106352","url":null,"abstract":"<div><div>The concept of optimality dominates contemporary human movement science, with researchers across biomechanics, motor control, and neuroscience routinely explaining observed behaviors as solutions that maximize or minimize objective functions. This paper critiques the pervasive application of optimality principles in human movement science. We argue that optimization frameworks mischaracterize biological systems for several reasons: (1) Evolution produces sufficient rather than optimal adaptations without foresight; (2) Biological systems serve multiple functions simultaneously with context-dependent prioritization; (3) Structure-function relationships co-evolve rather than optimize for fixed targets; (4) The fractal, multiscale nature of physiological signals makes traditional optimization mathematically meaningless—there are no well-defined minima or maxima in fractal landscapes; (5) Optimality models implicitly invoke a homunculus that selects optimization criteria; and (6) The concept is methodologically circular and unfalsifiable, as any behavior can be retroactively modeled as optimal for some function. Instead of this Cartesian illusion of optimality, we propose that human performance emerges as a dynamic, context-sensitive process across multiple scales. By breaking free from the optimization paradigm, movement science can develop more powerful explanatory frameworks that embrace the rich adaptive variability that defines true biological systems.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106352"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural foundations of creativity: A voxel-based meta-analysis of the activations and deactivations underlying creativity across linguistic, musical, and visual domains","authors":"Leidy Cubillos-Pinilla ,&nbsp;Allegre L. Hadida ,&nbsp;Sandra Baez ,&nbsp;Hernan Hernandez ,&nbsp;Mert Kizilyamac","doi":"10.1016/j.neubiorev.2025.106354","DOIUrl":"10.1016/j.neubiorev.2025.106354","url":null,"abstract":"<div><div>The neuroscience of creativity has proposed that shared and domain-specific brain mechanisms underlie creative thinking. However, greater nuance is needed in characterizing these mechanisms, and limited neuroimaging analyses, especially regarding the relationship between the Alternative Uses Task (AUT) and other linguistic tasks, have so far prevented a comprehensive understanding of the neural basis of creativity. This paper offers to fill these gaps with a closer examination of the contributions of the specific domains and the deactivations associated with creativity. We conduct a voxel-based meta-analysis of 43 neuroimaging studies involving 1118 participants. Using Seed-Based d Mapping, we investigate the spatial activity maps in the brain associated with overall creativity and with specific domains. Our findings reveal various domain-general mechanisms related to creativity, including working memory, the ability to connect distantly related concepts, the inhibition of conventional thought, interoception, internal goal orientation, mind wandering, and mental motor simulations. We also identify domain-specific mechanisms of creativity that differ by modality. Linguistic creativity requires inhibiting typical semantic associations, musical creativity involves auditory-motor integration and spontaneous expression, and visual creativity depends on inhibiting habitual visuospatial associations. Additionally, AUT is more effective at capturing novel tool manipulation and ideation rather than elaborative creative processes, which limits its scope. This meta-analysis underscores that creativity depends on multi-component neural circuits and highlights the need for future research to report deactivations, investigate neurofeedback applications, and analyze long-term and collaborative creative processes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106354"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective attention and eccentricity: A comprehensive review","authors":"Christian N.L. Olivers","doi":"10.1016/j.neubiorev.2025.106368","DOIUrl":"10.1016/j.neubiorev.2025.106368","url":null,"abstract":"<div><div>Human vision deals with two major limitations. First, vision is strongly foveated and deteriorates with eccentricity. Second, visual attention selectively prioritizes some stimuli over others. I review the functional and neurophysiological links between attention and eccentricity across a range of protocols including spatial cueing, crowding, dual tasking, and visual search, for both spatial and feature-based attention. The main conclusions are: 1) Attention and eccentricity are intrinsically intertwined. Functionally, attention partially compensates for peripheral vision’s limits, effectively expanding the functional visual field. Neurophysiologically, attention appears tightly linked to receptive field properties across eccentricity and the visual hierarchy. 2) We must distinguish between attention as a mechanism and attention as an effect. Whereas its effects may vary, attention as a mechanism appears overall remarkably stable across eccentricity. 3) Eccentricity ranges have been severely limited. We know little about attention further into the periphery and findings beyond the effective oculomotor range have been ambiguous. 4) The spatial profile of the attentional distribution and how this is achieved remains to be determined, with evidence for gradients, Mexican hats, and rings. By default attention appears biased towards the center, but whether and in what way cognitive load aggravates this ‘tunnel vision’ remains unclear. 5) Research on feature-based attention as a function of eccentricity has been markedly underrepresented. The scarce findings suggest that it operates globally across the visual field, but to what extent it does so uniformly and how this changes the functional visual field remains unknown. Future empirical and modeling directions are suggested.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106368"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the insula in the Takotsubo Cardiomyopathy: A scoping review","authors":"Laura Catalano ,&nbsp;Laura Sagliano ,&nbsp;Alessia Salzillo ,&nbsp;Ekaterina Ivanova ,&nbsp;Maria Pennacchio ,&nbsp;Martina Mancano ,&nbsp;Costanza Papagno ,&nbsp;Luigi Trojano","doi":"10.1016/j.neubiorev.2025.106369","DOIUrl":"10.1016/j.neubiorev.2025.106369","url":null,"abstract":"<div><div>Takotsubo cardiomyopathy (TC) is a transient cardiomyopathy secondary to emotional and/or physical stress. While its precise aetiology remains unclear, some evidence suggests a possible role for the insular cortex (IC), which modulates cardiovascular responses to stress. The IC is a key viscerosensory and visceromotor hub with widespread connections, and is implicated in interoceptive processing, emotional regulation, and autonomic control. Considering the strong link between stress and TC, and the insula involvement in stress and autonomic regulation, this scoping review aimed at exploring the role of the IC in the onset and modulation of TC. To this end, we examined the evidence derived from both lesional and neuroimaging studies. The results showed that TC can be related to strokes involving the IC, and is associated with structural and functional IC alterations, particularly in the left hemisphere and in female patients. Neuroimaging studies revealed abnormal IC connectivity during stress induction and in resting-state in patients with TC. These findings support the hypothesis that IC dysfunction contributes to autonomic changes in TC, beyond the effects of stress alone.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106369"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic changes and neurogenesis associated with socio-sexual behaviors","authors":"GD Rivera-Bautista ,&nbsp;DM Arzate ,&nbsp;D. Ávila-González ,&nbsp;AE Castro ,&nbsp;ER Vázquez-Martínez ,&nbsp;NF Díaz ,&nbsp;W. Portillo","doi":"10.1016/j.neubiorev.2025.106359","DOIUrl":"10.1016/j.neubiorev.2025.106359","url":null,"abstract":"<div><div>Epigenetic mechanisms are essential in neurogenesis during development and adulthood. DNA methylation, histone post-translational modifications, and non-coding RNAs regulate gene expression to maintain the neural stem cell pool and direct the fate of newborn neurons by modulating cell proliferation, migration, differentiation, maturation, and survival. Adult neurogenesis exhibits bidirectional interactions with non-social and socio-sexual factors such as sexual behavior, mate recognition, pair bonding, parental behavior, and offspring recognition. Epigenetic mechanism disruption has been implicated in metabolic diseases, cancer, and neurodegenerative disorders. Nevertheless, the precise role of these mechanisms in adult neurogenesis and their subsequent effects on behavior are not fully understood, particularly in the context of social interactions. This review examines emerging evidence that links epigenetic mechanisms and neurogenesis to the complex interplay between biological processes and socio-sexual behaviors, focusing specifically on socially monogamous prairie voles.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106359"},"PeriodicalIF":7.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroactive steroids role in mood disorders and PTSD","authors":"Rainer Rupprecht","doi":"10.1016/j.neubiorev.2025.106361","DOIUrl":"10.1016/j.neubiorev.2025.106361","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106361"},"PeriodicalIF":7.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Machine Learning predict therapeutic outcomes in affective and not affective psychosis? A systematic review and meta-analysis","authors":"Monopoli Camilla ,&nbsp;Colombo Federica ,&nbsp;Cazzella Tommaso ,&nbsp;Fortaner-Uyà Lidia ,&nbsp;Raffaelli Laura ,&nbsp;Calesella Federico ,&nbsp;Mario Gennaro ,&nbsp;Maccario Melania ,&nbsp;Pigoni Alessandro ,&nbsp;Maggioni Eleonora ,&nbsp;Brambilla Paolo ,&nbsp;Benedetti Francesco ,&nbsp;Vai Benedetta","doi":"10.1016/j.neubiorev.2025.106357","DOIUrl":"10.1016/j.neubiorev.2025.106357","url":null,"abstract":"<div><div>Machine learning (ML) could be useful in identifying reliable predictors of treatment response in affective and not affective psychoses, potentially helping to propose personalized interventions. In this systematic review and meta-analysis, we evaluated studies exploiting ML algorithms to predict the improvement of psychotic symptoms, cognition and quality of life in psychoses related to different treatments. We searched MEDLINE (PubMed), Web of Science, and PsycINFO databases updated until February 2024, identifying 64 articles published in English in peer-reviewed journals. We modelled a random-effects meta-analysis to estimate the overall accuracy reached in 51 studies. Subgroup analyses and meta regressions were performed to compare predictive accuracy across different predicted target class (i.e., improvers or responders <em>versus</em> not responders or treatment-resistant), diagnosis, input features, type and duration of treatments, ML algorithms, sample size, year of publication and quality assessment, evaluated with the PROBAST tool. ML models predicted a treatment response with a total accuracy of 80 % (95 %CI [0.76;0.83]), despite detecting a high heterogeneity (I²=0.89). Significant differences were observed between input features (<em>p</em> = .004) and treatments (<em>p</em> = .01). The best predictor was electroencephalography data (88 % of accuracy, 95 %CI [0.82;0.93], I²=0.50), followed by the combined treatments (85 % of accuracy, 95 %CI [0.82;0.87], I²=0.51). We identified a general low quality of studies, with 44 having a high risk of bias. Overall, ML seems a promising tool for predicting therapeutic outcomes in affective and not affective psychoses. However, specific attention should be paid to enhancing reproducibility and improving study methodology to better translate results into clinical practice.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106357"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does unfairness evoke anger or disgust? A quantitative neurofunctional dissection based on 25 years of neuroimaging","authors":"Xianyang Gan ,&nbsp;Ran Zhang ,&nbsp;Zihao Zheng ,&nbsp;Lan Wang ,&nbsp;Xi Yang ,&nbsp;Benjamin Klugah-Brown ,&nbsp;Ting Xu ,&nbsp;Nan Qiu ,&nbsp;Keith M. Kendrick ,&nbsp;Klaus Mathiak ,&nbsp;Justin Tiwald ,&nbsp;Dezhong Yao ,&nbsp;Benjamin Becker","doi":"10.1016/j.neubiorev.2025.106356","DOIUrl":"10.1016/j.neubiorev.2025.106356","url":null,"abstract":"<div><div>Over the last decades, the traditional ‘Homo economicus’ model has been increasingly challenged by converging evidence highlighting the critical impact of emotions on decision-making. A classic example is the perception of unfairness in the Ultimatum Game, where humans willingly sacrifice personal gains to punish fairness norm violators. While emotional mechanisms underlying such costly punishment are widely acknowledged, the distinct contributions of moral emotions, particularly anger and disgust, remain debated, partly due to methodological limitations in conventional experiments. Here, we leverage a quantitative neurofunctional dissection approach that integrates recent advances in neuroimaging meta-analyses, behavioral-level, network-level, and neurochemical-level decoding, drawing on data from 3266 participants from functional neuroimaging studies to determine the common and distinct neural representations between unfairness and the two moral emotions. Our results reveal that experiencing unfairness engages a widespread bilateral network encompassing insular, cingulate, and frontal regions, with dorsal striatal regions mediating the decision to reject unfair offers. Disgust engages a defensive-avoidance circuit encompassing amygdalar, occipital, and frontal regions, while anger engages non-overlapping systems including mid-cingulate, thalamic, and frontal regions. Unfairness shares common activation with both anger and disgust, respectively, in the anterior and mid-insula, while the latter additionally shows common recruitment of ventrolateral prefrontal and orbitofrontal cortices. Multimodal network, behavioral, and serotonergic decoding provide a more refined dissection of these results. Collectively, our results suggest a shared neuroaffective foundation through which emotions impact unfairness-induced punishment behavior, supporting the existence of a core brain circuit evolutionarily shaped to protect individuals from personal harm and enforce social norms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106356"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}