Neuroscience and Biobehavioral Reviews最新文献

{"title":"Noradrenergic alterations associated with early life stress","authors":"Megan Sheppard ,&nbsp;Jalil Rasgado-Toledo ,&nbsp;Niall Duncan ,&nbsp;Rebecca Elliott ,&nbsp;Eduardo A. Garza-Villarreal ,&nbsp;Nils Muhlert","doi":"10.1016/j.neubiorev.2024.105832","DOIUrl":"10.1016/j.neubiorev.2024.105832","url":null,"abstract":"<div><p>Significant stress in childhood or adolescence is linked to both structural and functional changes in the brain in human and analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations in response to these early life stressors, which may impact upon the sensitivity and time course of key adrenergic activities, such as rapid autonomic stress responses (the ‘fight or flight response’). The locus-coeruleus noradrenergic (LC-NA) network, a key stress-responsive network in the brain, displays numerous changes in response to significant early- life stress. Here, we review the relationship between NA and the neurobiological changes associated with early life stress and set out future lines of research that can illuminate how brain circuits and circulating neurotransmitters adapt in response to childhood stressors</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105832"},"PeriodicalIF":7.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003014/pdfft?md5=6a745bbffceb03e7a0e20a0f55a456ea&pid=1-s2.0-S0149763424003014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity","authors":"Subrata Pramanik ,&nbsp;Harini Devi M ,&nbsp;Saswata Chakrabarty ,&nbsp;Berkay Paylar ,&nbsp;Ajay Pradhan ,&nbsp;Manisha Thaker ,&nbsp;Shamini Ayyadhury ,&nbsp;Arulmani Manavalan ,&nbsp;Per-Erik Olsson ,&nbsp;Gopal Pramanik ,&nbsp;Klaus Heese","doi":"10.1016/j.neubiorev.2024.105834","DOIUrl":"10.1016/j.neubiorev.2024.105834","url":null,"abstract":"<div><p>Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS), exert a pivotal influence on brain development, homeostasis, and functionality, encompassing critical roles during both aging and pathological states. Recent advancements in comprehending brain plasticity and functions have spotlighted conspicuous variances between male and female brains, notably in neurogenesis, neuronal myelination, axon fasciculation, and synaptogenesis. Nevertheless, the precise impact of microglia on sex-specific brain cell plasticity, sculpting diverse neural network architectures and circuits, remains largely unexplored. This article seeks to unravel the present understanding of microglial involvement in brain development, plasticity, and function, with a specific emphasis on microglial signaling in brain sex polymorphism. Commencing with an overview of microglia in the CNS and their associated signaling cascades, we subsequently probe recent revelations regarding molecular signaling by microglia in sex-dependent brain developmental plasticity, functions, and diseases. Notably, C-X3-C motif chemokine receptor 1 (CX3CR1), triggering receptors expressed on myeloid cells 2 (TREM2), calcium (Ca²⁺), and apolipoprotein E (APOE) emerge as molecular candidates significantly contributing to sex-dependent brain development and plasticity. In conclusion, we address burgeoning inquiries surrounding microglia's pivotal role in the functional diversity of developing and aging brains, contemplating their potential implications for gender-tailored therapeutic strategies in neurodegenerative diseases.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"165 ","pages":"Article 105834"},"PeriodicalIF":7.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Alzheimer’s disease with brain stimulation: From preclinical models to non-invasive stimulation in humans","authors":"Ilenia Lanni ,&nbsp;Giulia Chiacchierini ,&nbsp;Costanza Papagno ,&nbsp;Valerio Santangelo ,&nbsp;Patrizia Campolongo","doi":"10.1016/j.neubiorev.2024.105831","DOIUrl":"10.1016/j.neubiorev.2024.105831","url":null,"abstract":"<div><p>Alzheimer's disease (AD) is a severe and progressive neurodegenerative condition that exerts detrimental effects on brain function. As of now, there is no effective treatment for AD patients. This review explores two distinct avenues of research. The first revolves around the use of animal studies and preclinical models to gain insights into AD's underlying mechanisms and potential treatment strategies. Specifically, it delves into the effectiveness of interventions such as Optogenetics and Chemogenetics, shedding light on their implications for understanding pathophysiological mechanisms and potential therapeutic applications. The second avenue focuses on non-invasive brain stimulation (NiBS) techniques in the context of AD. Evidence suggests that NiBS can successfully modulate cognitive functions associated with various neurological and neuropsychiatric disorders, including AD, as demonstrated by promising findings. Here, we critically assessed recent findings in AD research belonging to these lines of research and discuss their potential impact on the clinical horizon of AD treatment. These multifaceted approaches offer hope for advancing our comprehension of AD pathology and developing novel therapeutic interventions.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"165 ","pages":"Article 105831"},"PeriodicalIF":7.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003002/pdfft?md5=cb7fd3c1a3bd2133a6a670e522c876ba&pid=1-s2.0-S0149763424003002-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the common of descent of neurology, psychiatry and anthropology","authors":"Daniel R. Wilson","doi":"10.1016/j.neubiorev.2024.105827","DOIUrl":"10.1016/j.neubiorev.2024.105827","url":null,"abstract":"<div><p>It is little appreciated not only how closely linked are the disciplines of neurology, psychiatry, and anthropology but even more so the degree to which they share a “common ancestry”. This paper briefly reviews the definition and historical origins of each area of study to then begin to illustrate how their “genealogies” overlap. This illustration is by way of a sampling of the many key figures who contributed to the rise of not just neurology, psychiatry or anthropology but of all three disciplines. That is, a selective review is undertaken of paragons whose careers bridged medicine, neuropsychiatry, and anthropology. A sampling from among the dozens who have made major contributions to spanning these disciplines illuminates the significant extent of their co-mingled intellectual ancestry. This series is akin to a data table of necessarily concise biographical vignettes – past scholars with some or full medical training who also advanced both anthropology and neuropsychiatry as these disciplines grew into intellectual maturity. Each is, in a sense, a data point that bolsters the overarching thesis that the intellectual history of these disciplines have shared ancestry. Thus, even this preliminary and topical survey of a few past “exemplars” underscores the importance of this unique intellectual siblingship. Moreover, there is now a profusion of living scholars who add fulsomely to what might be deemed this ‘trilateral marriage’ of anthropology, psychiatry, and neurology. A compilation of more contemporary contributors is well worthy of a future review that expands from this first consideration. This initial work is meant to engender more robust scholarship that better elucidates and, thereby, enriches and enlivens further work while also uncovering new avenues of deeper insight, notably as to the “conceptual and heuristic progression” of evolutionary neurosciences with respect to the normative and pathologic.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"166 ","pages":"Article 105827"},"PeriodicalIF":7.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002963/pdfft?md5=4df137dcfe006960762aff26a552c151&pid=1-s2.0-S0149763424002963-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the influence of Pavlovian cues on decision-making: A pre-registered meta-analysis on Pavlovian-to-instrumental transfer","authors":"Marco Badioli,&nbsp;Luigi A.E. Degni,&nbsp;Daniela Dalbagno,&nbsp;Claudio Danti,&nbsp;Francesca Starita,&nbsp;Giuseppe di Pellegrino,&nbsp;Mariagrazia Benassi,&nbsp;Sara Garofalo","doi":"10.1016/j.neubiorev.2024.105829","DOIUrl":"10.1016/j.neubiorev.2024.105829","url":null,"abstract":"<div><p>Amidst the replicability crisis, promoting transparency and rigor in research becomes imperative. The Pavlovian-to-Instrumental Transfer (PIT) paradigm is increasingly used in human studies to offer insights into how Pavlovian cues, by anticipating rewards or punishments, influence decision-making and potentially contribute to the development of clinical conditions. However, research on this topic faces challenges, including methodological variability and the need for standardized approaches, which can undermine the quality and robustness of experimental findings. Hence, we conducted a meta-analysis to unravel the methodological, task-related, individual, training, and learning factors that can modulate PIT. By scrutinizing these factors, the present meta-analysis reviews the current literature on human PIT, provides practical guidelines for future research to enhance study outcomes and refine methodologies, and identifies knowledge gaps that can serve as a direction for future studies aiming to advance the comprehension of how Pavlovian cues shape decision-making.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105829"},"PeriodicalIF":7.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002987/pdfft?md5=670e652edd8c3d06de2a6dc8718ffd02&pid=1-s2.0-S0149763424002987-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of action observation in speech and language rehabilitation: A systematic review and meta-analysis","authors":"Victor Francisco ,&nbsp;Frédéric Louis ,&nbsp;Maxime Billot ,&nbsp;Morgane Le Bourvellec ,&nbsp;Arnaud Decatoire ,&nbsp;Romain David ,&nbsp;Christel Bidet-Ildei","doi":"10.1016/j.neubiorev.2024.105826","DOIUrl":"10.1016/j.neubiorev.2024.105826","url":null,"abstract":"<div><p>In this systematic review and meta-analysis, our aim was to identify and quantify evidence of action observation therapy (AOT) efficacy in managing language deficits in patients with aphasia. This study conducts two quantitative investigations: firstly, comparing the effects of AOT and conventional control therapy in different groups, and secondly, analyzing within AOT group to explore potential moderators of AOT effectiveness. Four databases were searched up until August 2023 to find studies utilizing AOT for aphasia management. Seven eligible studies were included. The main analyses revealed moderate evidence of improvement in naming tasks, with a large effect size (Hedge’s g = 1.27, 95 %CI [0.44; 2.09], p = 0.003, I2 &lt; 25) following AOT compared to control interventions. Furthermore, to be efficient, AOT should focus on human actions (e.g., running, jumping) rather than non-human actions (e.g., meowing or barking). These findings indicate that AOT is a promising alternative complementary approach for patients with aphasia. Future research should confirm the potential benefits of AOT with more randomized controlled studies and aim to clarify the minimal dose necessary and the possibility of transfer to various language tasks.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105826"},"PeriodicalIF":7.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002951/pdfft?md5=ea26604aeda730614aed1cd0a22d2092&pid=1-s2.0-S0149763424002951-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cerebellum and the Mirror Neuron System: A matter of inhibition? From neurophysiological evidence to neuromodulatory implications. A narrative review","authors":"Annibale Antonioni ,&nbsp;Emanuela Maria Raho ,&nbsp;Sofia Straudi ,&nbsp;Enrico Granieri ,&nbsp;Giacomo Koch ,&nbsp;Luciano Fadiga","doi":"10.1016/j.neubiorev.2024.105830","DOIUrl":"10.1016/j.neubiorev.2024.105830","url":null,"abstract":"<div><p>Mirror neurons show activity during both the execution (AE) and observation of actions (AO). The Mirror Neuron System (MNS) could be involved during motor imagery (MI) as well. Extensive research suggests that the cerebellum is interconnected with the MNS and may be critically involved in its activities. We gathered evidence on the cerebellum's role in MNS functions, both theoretically and experimentally. Evidence shows that the cerebellum plays a major role during AO and MI and that its lesions impair MNS functions likely because, by modulating the activity of cortical inhibitory interneurons with mirror properties, the cerebellum may contribute to visuomotor matching, which is fundamental for shaping mirror properties. Indeed, the cerebellum may strengthen sensory-motor patterns that minimise the discrepancy between predicted and actual outcome, both during AE and AO. Furthermore, through its connections with the hippocampus, the cerebellum might be involved in internal simulations of motor programs during MI. Finally, as cerebellar neuromodulation might improve its impact on MNS activity, we explored its potential neurophysiological and neurorehabilitation implications.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105830"},"PeriodicalIF":7.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002999/pdfft?md5=5cf5349481e8b4633df5da876e127f53&pid=1-s2.0-S0149763424002999-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of the associations between motor milestone timing and motor development in neurodevelopmental conditions","authors":"Aislinn Bowler ,&nbsp;Tomoki Arichi ,&nbsp;Chloe Austerberry ,&nbsp;Pasco Fearon ,&nbsp;Angelica Ronald","doi":"10.1016/j.neubiorev.2024.105825","DOIUrl":"10.1016/j.neubiorev.2024.105825","url":null,"abstract":"<div><p>Early motor skills may be important early markers of neurodevelopmental conditions or predictors of their later onset. To explore this, we conducted a systematic review and meta-analysis of infant motor skill assessments in those who go on to gain a clinical diagnosis of autism, attention deficit hyperactivity disorder (ADHD), schizophrenia, language conditions, tic disorders, or developmental coordination disorder (DCD). In total, 63 articles met inclusion criteria. Three three-level meta-analyses were run. Meta-analysis of milestone achievement in <em>N</em>= 21205 individuals revealed gross motor milestones were significantly delayed compared to controls (g= 0.53, <em>p</em>&lt; 0.001). Subgroup analyses revealed autism (g= 0.63) and DCD (g= 0.53) had the highest magnitude delays. Specific delays were revealed for holding the head up (g= 0.21), sitting (g= 0.28), standing (g= 0.35), crawling (g= 0.19), and walking (g= 0.71). Meta-analyses of standardised motor skill measurements in <em>N=</em> 1976 individuals revealed reduced performance compared to controls in autism and language conditions (g= −0.54, <em>p</em>&lt; 0.001). Together, these findings demonstrate delayed milestone attainment and motor impairments in early childhood in neurodevelopmental conditions.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105825"},"PeriodicalIF":7.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S014976342400294X/pdfft?md5=7ea28107e3bb8710ace6aa940b8f25cf&pid=1-s2.0-S014976342400294X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual factors associated with subjective effects of cannabis: A systematic review and meta-analysis","authors":"Mouktika M. Ayyagari ,&nbsp;Derek Heim ,&nbsp;Harry R. Sumnall ,&nbsp;Rebecca L. Monk","doi":"10.1016/j.neubiorev.2024.105822","DOIUrl":"10.1016/j.neubiorev.2024.105822","url":null,"abstract":"<div><h3>Background</h3><p>Cannabis is consumed in various social and environmental settings, and such contexts may be important predictors of subjective effects. The aim of this systematic review and meta-analysis was to examine the relationship between contextual factors and subjective effects of cannabis.</p></div><div><h3>Methods</h3><p>A PRISMA-guided search of MEDLINE, Embase, PsycINFO, Global Health, and Google Scholar yielded 29 studies.</p></div><div><h3>Results</h3><p>Study type (Ecological Momentary Assessment or Experimental) was a significant predictor of intoxication effects, and experimental studies had a greater pooled effect size (<em>z</em> =.296,95 % CI [.132,.478], <em>p</em>=.004) than Ecological Momentary Assessment (EMA) studies (<em>z</em> =.071,95 % CI [.011,.130], <em>p</em> =.02). Contextual conditions (environment, social group, expectancy, time of day, day of week) were not significant predictors of cannabis effects.</p></div><div><h3>Conclusion</h3><p>Findings did not point to a significant association between contextual conditions and subjective effects. However, as current literature is methodologically weak, it may be premature to conclude that subjective effects are not shaped by contextual factors. In view of policy and therapeutic implications, replications and study refinements are recommended.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105822"},"PeriodicalIF":7.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002914/pdfft?md5=0ba88a07be1c982d80f82f5c64eedac4&pid=1-s2.0-S0149763424002914-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of environmental pollutants to the risk of autism and other neurodevelopmental disorders: A systematic review of case-control studies","authors":"A.M. Tartaglione ,&nbsp;L. Camoni ,&nbsp;G. Calamandrei,&nbsp;F. Chiarotti,&nbsp;A. Venerosi","doi":"10.1016/j.neubiorev.2024.105815","DOIUrl":"10.1016/j.neubiorev.2024.105815","url":null,"abstract":"<div><p>Exposure to environmental pollutants, such as metals, pesticides, and air pollutants during early life, is a risk factor for neurodevelopmental disorders (NDDs), including Autism Spectrum Disorder (ASD). Our systematic review aimed to select and summarize more recent case-control studies that examined the association between prenatal and early postnatal exposure to environmental pollutants and NDDs. We searched five databases (Web of Science, PubMed, Embase, Scopus, Ovid), screened 2261 records, and included 24 eligible case-control studies. Meta-analyses were conducted on subgroups of at least three studies that shared both the outcome and the exposure. A noteworthy discovery from this literature review is the existence of non-linear or non-monotonic dose-response relationships between the exposure to certain metals and the risk of ASD. The meta-analysis revealed a significant association between exposure to particular matter (PM)₁₀ during the first year of life and the risk of ASD. Overall, studies included in our systematic review indicate that exposure to several pollutants within the first three years of life was significantly associated with the risk of NDDs.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"164 ","pages":"Article 105815"},"PeriodicalIF":7.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002847/pdfft?md5=98aae29fba4f83c0dc74c3bd44828fb8&pid=1-s2.0-S0149763424002847-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}