Neuroscience and Biobehavioral Reviews最新文献

{"title":"A beautiful loop: An active inference theory of consciousness","authors":"Ruben Laukkonen ,&nbsp;Karl Friston ,&nbsp;Shamil Chandaria","doi":"10.1016/j.neubiorev.2025.106296","DOIUrl":"10.1016/j.neubiorev.2025.106296","url":null,"abstract":"<div><div>Can active inference model consciousness? We offer three conditions implying that it can. The first condition is the simulation of a world model, which determines what can be known or acted upon; namely an <em>epistemic field</em>. The second is inferential competition to enter the world model. Only the inferences that coherently reduce long-term uncertainty win, evincing a selection for consciousness that we call <em>Bayesian binding</em>. The third is <em>epistemic depth</em>, which is the recurrent sharing of the Bayesian beliefs throughout the system. Due to this recursive loop in a hierarchical system (such as a brain) the world model contains the knowledge that it exists. This is distinct from self-consciousness, because the world model knows itself non-locally and continuously evidences this knowing (i.e., <em>field-evidencing</em>). Formally, we propose a hyper-model for precision-control, whose latent states (or parameters) encode and control the overall structure and weighting rules for all layers of inference. These globally integrated preferences for precision enact the epistemic agency and flexibility reminiscent of general intelligence. This <em>Beautiful Loop Theory</em> is also deeply revealing about altered states, meditation, and the full spectrum of conscious experience.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106296"},"PeriodicalIF":7.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics: Potential non-protein biomarker candidates of Parkinson's disease","authors":"Michal Kaleta ,&nbsp;Gabriel Gonzalez ,&nbsp;Eva Hényková ,&nbsp;Kateřina Menšíková ,&nbsp;Dorota Koníčková ,&nbsp;Petr Kaňovský","doi":"10.1016/j.neubiorev.2025.106310","DOIUrl":"10.1016/j.neubiorev.2025.106310","url":null,"abstract":"<div><div>Despite the growing number of patients with neurodegenerative diseases, especially Parkinson's disease, and the associated increasing pressure on global healthcare systems, there is still a lack of reliable laboratory methods that allow for the rapid and highly accurate diagnosis of these diseases at a pre-symptomatic or early stage, i.e., before irreversible pathomorphological and functional changes occur. Furthermore, current treatment strategies remain limited to the management of symptoms and fail to address the underlying causes of Parkinson's disease. This diagnostic and therapeutic gap is becoming increasingly critical. Recent advances in metabolomics, fuelled by major improvements in analytical technologies, now offer unprecedented opportunities to identify novel biomarkers and therapeutic targets. In this context, intermediates of tryptophan metabolism, along with dopamine metabolites such as aminochrome, appear to be particularly promising candidates. They include various neurotoxic, neuroprotective, and otherwise bioactive molecules, which are directly involved in regulating nervous system functions and closely interact with neural structures. Aminochrome, for instance, plays a pivotal role in inducing neurodegenerative processes, including the misfolding of α-synuclein, a hallmark of Parkinson's disease. Given the accelerating development of metabolomic platforms and the urgent clinical need for early diagnosis and novel therapeutic strategies, the exploration of metabolite-based biomarkers and targets represents a timely and highly relevant research direction.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106310"},"PeriodicalIF":7.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding light on the functional significance of opsins: Insights from fish","authors":"Austin H. Cooper,&nbsp;Simon N. Archer,&nbsp;Matthew O. Parker","doi":"10.1016/j.neubiorev.2025.106305","DOIUrl":"10.1016/j.neubiorev.2025.106305","url":null,"abstract":"<div><div>Since the cloning of the first opsin in 1983, numerous opsin transcripts have been discovered across a variety of tissues and species. However, the functional significance of many of these opsins remains unclear, particularly for non-visual opsins that function outside the visual system, with their downstream processes largely unexplored. Fish offer a promising model to bridge this knowledge gap, due to their extensive opsin repertoire, genetic tractability, and evolutionary relevance. This review critically synthesises current understanding of the downstream processes regulated by opsins in fish, with a focus on evolutionary adaptations, the circadian clock and dermal colour change. Rather than being residual photoreceptors, non-visual opsins appear to be active mediators of physiological and behavioural responses. By connecting molecular mechanisms with development, behaviour, and environmental sensing, we propose that opsins serve as key components of sensory integration and adaptation. In doing so, this review reframes the study of opsins beyond vision, offering new perspectives on their widespread expression and functional versatility, ultimately advancing our understanding of photoreceptor biology.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106305"},"PeriodicalIF":7.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of prefrontal cortex in auditory-verbal hallucinations: Actor or passive bystander?","authors":"Kenneth Hugdahl ,&nbsp;André Aleman","doi":"10.1016/j.neubiorev.2025.106306","DOIUrl":"10.1016/j.neubiorev.2025.106306","url":null,"abstract":"<div><div>In this paper we discuss the role of the prefrontal cortex (PFC) in schizophrenia and particularly in auditory verbal hallucinations (AVH). The paper starts with a review of the concept of hypofrontality in the 1970s and a view of PFC as a passive bystander unable to regulate or control internally generated sensory impulses. We further discuss the relationship between PFC and memory processes and the hypothesis that AVH experiences occur because of intrusions of negative emotional memories, and regulation of the emotional content of the voices. Similarly, AVH experiences can be the result of failure of reality monitoring, due to aberrant discrimination between internally generated thoughts and external influences, also dependent on PFC functioning. We subsequently introduce a new view of the role of the PFC as an actor, or active agent, a kind of hyperfrontality seen in network connectivity studies. We suggest that both hypo- and hyperfrontality models may be an oversimplification of the complex relationship between brain and behavior in the generation of AVH-experiences. Rather, the impaired ability to regulate inter-network dynamics when environmental conditions change may play a central role. We therefore discuss how task-positive and task-negative cortical networks are dynamically up- and down-regulated across time at the diagnostic level, and how this affects the presence or absence of an AVH experience at the symptom level. We conclude by suggesting that it is this failure of dynamic interplay between large-scale networks that is critical for an understanding of schizophrenia in general and auditory verbal hallucinations in particular.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106306"},"PeriodicalIF":7.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction error and memory updating: Challenges ahead","authors":"Noa Ofen ,&nbsp;Zhijian Chen","doi":"10.1016/j.neubiorev.2025.106308","DOIUrl":"10.1016/j.neubiorev.2025.106308","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106308"},"PeriodicalIF":7.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic functional neuroimaging connectivity features in depression and anxiety in adolescence: A systematic review","authors":"Lei Luo ,&nbsp;Marko Dimitrovski ,&nbsp;Toby Wise ,&nbsp;Raquel Iniesta","doi":"10.1016/j.neubiorev.2025.106309","DOIUrl":"10.1016/j.neubiorev.2025.106309","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has indicated that individuals with depression and anxiety disorders may similarly changes in brain connectivity compared to healthy control. These patterns of altered connectivity may emerge upon disorder onset in adolescence. Establishing shared and specific patterns at this early stage can help investigate underlying biological processes, with implications for intervention, but remaining unclear whether adolescent MDD and AD are associated with similar or distinct functional connectivity patterns.</div></div><div><h3>Objective</h3><div>To determine similarities and differences in brain connectivity neuroimaging between adolescent MDD and AD.</div></div><div><h3>Methods</h3><div>Eligibility criteria were established following PICOS. We conducted searches using controlled vocabulary and searching syntax on PubMed, Scopus, ScienceDirect, and Web of Science databases, up to January 31, 2024. The quality of papers was assessed using PRISMA.</div></div><div><h3>Results</h3><div>5137 papers were retrieved, with 38 meeting the inclusion criteria. In the synthesis of results, it was found that adolescent MDD patients exhibit increased connectivity within default mode network (DMN), especially in areas posterior cingulate cortex and medial prefrontal cortex; and salience network (SN) including anterior cingulate cortex and insula. Adolescent AD patients show hyperconnectivity and dysregulated activity in DMN, enhanced connectivity within SN including amygdala. MDD and AD both show involvement of limbic system including amygdala and hippocampus.</div></div><div><h3>Conclusion</h3><div>Results suggest both adolescent MDD and AD exhibit alterations in connectivity of SN; disrupted connectivity within DMN; dysregulation in connectivity between limbic and sensorimotor system. They also differentiate in certain connectivity patterns. These could serve as biomarkers for future research on transdiagnostic features across psychiatric disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106309"},"PeriodicalIF":7.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PTCHD1 protein: A prominent actor in brain function and in neurodevelopmental disorders","authors":"Dévina C. Ung ,&nbsp;Stéphane Martin ,&nbsp;Yann Hérault ,&nbsp;Frédéric Laumonnier","doi":"10.1016/j.neubiorev.2025.106307","DOIUrl":"10.1016/j.neubiorev.2025.106307","url":null,"abstract":"<div><div>Neurodevelopmental disorders (NDDs) encompass a broad spectrum of conditions, including intellectual disability (ID), Attention Deficit Hyperactivity Disorders (ADHD) and autism spectrum disorders (ASD), often linked to disrupted synaptic functionality. Among the major NDD genes, <em>PTCHD1 (Patched Domain Containing 1)</em> encodes a transmembrane protein which acts as a crucial regulator of synaptic function. Mutations and microdeletions in <em>PTCHD1</em> have been associated with global developmental delays such as ID, ASD, and behavioral abnormalities. This review explores the neurodevelopmental functions of PTCHD1, particularly its position within the synaptic environment, from the association with the postsynaptic proteome to the regulation of several major neuronal signaling pathways, cholesterol homeostasis and receptor trafficking. In a pathophysiological context, studies in <em>Ptchd1</em> knockout mouse models revealed abnormal behavioral phenotypes, linked to synaptic impairments, including reduced excitatory postsynaptic currents and altered dendritic morphology similarly to recent results on human-derived neuronal models. By synthesizing findings from genetic, molecular, and behavioral studies, this review underscores the multifaceted roles of PTCHD1 in neurodevelopment and synaptic regulation. Understanding its function in synaptic pathways may provide crucial insights into the pathophysiology of NDDs, emphasizing the need for further research to clarify its role as a potential synaptic, orphan receptor.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106307"},"PeriodicalIF":7.9,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of exercise interventions on depressive and anxiety symptoms in cancer patients: A systematic review and network meta-analysis","authors":"Liang Li,&nbsp;Xuxiang Chen,&nbsp;Chengyan Yang,&nbsp;Zhengxin Hui,&nbsp;Tonggang Fan","doi":"10.1016/j.neubiorev.2025.106304","DOIUrl":"10.1016/j.neubiorev.2025.106304","url":null,"abstract":"<div><h3>Objective</h3><div>The effects of different exercise types on symptoms of depression and anxiety in patients with cancer were evaluated using a network meta-analysis (NMA) to provide an evidence-based guide for choosing appropriate exercise interventions.</div></div><div><h3>Methods</h3><div>Four databases were systematically searched from inception to October 2024. A NMA was performed using Stata 18.0 software through a random-effects model based on the frequentist framework. The study protocol was registered on the International Prospective Register of Systematic Reviews platform (Identification number: CRD42024605970).</div></div><div><h3>Results</h3><div>Seventy-two studies, totaling 6235 patients, were included to assess the effects of eight types of exercise on depressive symptoms in patients with cancer. The top three ranked by surface under the cumulative ranking curve (SUCRA) were yoga (highest probability, SUCRA=74.9 %), combination exercise (SUCRA=72.6 %), and dance (SUCRA=68.7 %). Forty-five studies, totaling 3845 patients, evaluated the effects of six types of exercise on anxiety symptoms in patients with cancer. The top three ranked by SUCRA were yoga (highest probability, SUCRA=92.5 %), aerobic exercise (SUCRA=61 %), and walking (SUCRA=54.4 %).</div></div><div><h3>Conclusions</h3><div>Yoga appears to be the most effective exercise option for alleviating symptoms of depression and anxiety in patients with cancer during rehabilitation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106304"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ALE meta-analysis of pain processing alterations in fibromyalgia: Toward an evidence-based process model","authors":"Marco Cavicchioli ,&nbsp;Alberto Caruso ,&nbsp;Andrea Scalabrini ,&nbsp;Alessandro Torelli ,&nbsp;Sara Bottiroli ,&nbsp;Anna Pichiecchio ,&nbsp;Elena Prodi ,&nbsp;Martina Cangelosi ,&nbsp;Carlo Lai ,&nbsp;Paolo Vitali ,&nbsp;Luca Maria Sconfienza ,&nbsp;Piercarlo Sarzi-Puttini ,&nbsp;Federica Galli","doi":"10.1016/j.neubiorev.2025.106303","DOIUrl":"10.1016/j.neubiorev.2025.106303","url":null,"abstract":"<div><div>It has been hypothesized that core pain-related symptoms of fibromyalgia (FM) might be associated with alterations of pain processing mechanisms. On the one hand, several fMRI studies were conducted to evaluate possible alterations of neural responsiveness toward the presentation of different kinds of noxious stimuli among patients with FM. On the other hand, a quantitative summary of these findings is still lacking. Accordingly, it was conducted an ALE meta-analysis (FWE, p &lt; .05) of studies comparing brain responsiveness to the administration of painful stimuli between patients with FM and healthy controls (HCs). Twenty-one studies were included for meta-analytic procedures. Results showed 3 main findings: i) key areas of the pain matrix (i.e., dorsal anterior cingulate cortex [dACC], basal ganglia and thalamic nuclei) were commonly involved in pain processing in both FM patients and HCs; ii) pain processing in FM patients were characterized by a recruitment of the right insula; whereas, HCs mainly recruited prefrontal areas; iii) patients with FM, compared to HCs, showed an increased magnitude of dACC and supplementary motor area responsiveness toward the presentation of painful stimuli. These findings suggest that altered pain processing in FM is characterized by: i) an increased salience of painful stimuli, which are processed at a viscero-somatic non-mentalized level; ii) high intensity and low granularity of painful experiences accompanied by a negative valence, and modulated through maladaptive avoidance strategies; iii) the development of hypervigilance toward any potential harmful stimuli</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106303"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of non-pharmacological interventions on vagally-mediated heart rate variability (vmHRV) in individuals with depression: A systematic review and meta-analysis","authors":"Zoey Yutong Li ,&nbsp;Jeremy Rui Chang ,&nbsp;Cong Wang ,&nbsp;Minxia Jin ,&nbsp;Ian Hoyin Cheng ,&nbsp;Suk-yu Yau ,&nbsp;Waiming Cheung ,&nbsp;Hector Winghong Tsang","doi":"10.1016/j.neubiorev.2025.106300","DOIUrl":"10.1016/j.neubiorev.2025.106300","url":null,"abstract":"<div><h3>Objectives</h3><div>This study seeks to explore the impact of non-pharmacological interventions (NPIs) on vagally-mediated heart rate variability (vmHRV) in subjects experiencing depression. Additionally, it aims to delineate the relationship between vmHRV alterations and the severity of depressive symptoms.</div></div><div><h3>Methods</h3><div>Search was systematically performed on RCTs studies across various databases. These included Embase, the Cochrane Central Register of Controlled Trials, Medline via EBSCO, PsycINFO accessed through ProQuest, and the Web of Science, capturing all entries until March 11, 2024.</div></div><div><h3>Results</h3><div>The analysis revealed that NPIs generally exerted small to moderate beneficial effects on cardiac parasympathetic nervous system (PNS) markers such as the root mean square of successive differences (RMSSD) ([SMD] = 0.266, 95 % confidence interval [CI] 0.029–0.503) and high-frequency power (HF) (SMD = 0.178, 95 % CI 0.018–0.337). Specifically, mind-body exercises demonstrated moderate to large enhancements in RMSSD (SMD = 0.689, 95 % CI 0.265–1.112) and a moderate improvement in HF (SMD = 0.498, 95 % CI 0.134–0.863) immediately following the interventions. Conversely, psychological interventions did not show significant immediate post-intervention vmHRV enhancements; however, subsequent assessments revealed a moderate increase in HF (SMD = 0.477, 95 % CI 0.177–0.786) during short-term follow-ups. Moreover, substantial correlations were observed between vmHRV improvements and reductions in depression severity.</div></div><div><h3>Conclusions</h3><div>Our findings indicated that NPIs effectively enhance vmHRV and reduce depressive symptoms. This underscores the effectiveness of both mind-body exercises and psychological interventions. Furthermore, alterations in vmHRV may serve as viable predictors for the success of depression treatments.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106300"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}