Neuroscience and Biobehavioral Reviews最新文献

{"title":"Corrigendum to “Emotion Regulation: From neural circuits to a transdiagnostic perspective” [Neurosci. Biobehav. Rev. (2025) 168:105960]","authors":"Carmen Morawetz , Florian J. Hemetsberger , Angela R. Laird , Nils Kohn","doi":"10.1016/j.neubiorev.2024.105998","DOIUrl":"10.1016/j.neubiorev.2024.105998","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105998"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The neural correlates of physical exercise-induced general cognitive gains: A systematic review and meta-analysis of functional magnetic resonance imaging studies” [Neurosci. Biobehav. Rev. 169 (2025) 106008]","authors":"Geng Li , Haishuo Xia , Gesi Teng , Antao Chen","doi":"10.1016/j.neubiorev.2025.106025","DOIUrl":"10.1016/j.neubiorev.2025.106025","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106025"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial transplantation in brain disorders: Achievements, methods, and challenges","authors":"Aurélien Riou ,&nbsp;Aline Broeglin ,&nbsp;Amandine Grimm","doi":"10.1016/j.neubiorev.2024.105971","DOIUrl":"10.1016/j.neubiorev.2024.105971","url":null,"abstract":"<div><div>Mitochondrial transplantation is a new treatment strategy aimed at repairing cellular damage by introducing healthy mitochondria into injured cells. The approach shows promise in protecting brain function in various neurological disorders such as traumatic brain injury/ischemia, neurodegenerative diseases, cognitive disorders, and cancer. These conditions are often characterized by mitochondrial dysfunction, leading to impaired energy production and neuronal death. The review highlights promising preclinical studies where mitochondrial transplantation has been shown to restore mitochondrial function, reduce inflammation, and improve cognitive and motor functions in several animal models. It also addresses significant challenges that must be overcome before this therapy can be clinically applied. Current efforts to overcome these challenges, including advancements in isolation techniques, cryopreservation methods, finding an appropriate mitochondria source, and potential delivery routes, are discussed. Considering the rising incidence of neurological disorders and the limited effectiveness of current treatments, this review offers a comprehensive overview of the current state of mitochondrial transplantation research and critically assesses the remaining obstacles. It provides valuable insights that could steer future studies and potentially lead to more effective treatments for various brain disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105971"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased atherogenicity in mood disorders: a systematic review, meta-analysis and meta-regression","authors":"Ketsupar Jirakran ,&nbsp;Abbas F. Almulla ,&nbsp;Thapanee Jaipinta ,&nbsp;Asara Vasupanrajit ,&nbsp;Priabprat Jansem ,&nbsp;Chavit Tunvirachaisakul ,&nbsp;Elizabet Dzhambazova ,&nbsp;Drozdstoj St. Stoyanov ,&nbsp;Michael Maes","doi":"10.1016/j.neubiorev.2025.106005","DOIUrl":"10.1016/j.neubiorev.2025.106005","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) and bipolar disorder (BD) often coexist with metabolic syndrome. Both are linked to increased atherogenicity and a higher risk of cardiovascular diseases. Nevertheless, a comprehensive analysis of key atherogenic biomarkers in MDD/BD is still lacking.</div></div><div><h3>Objectives</h3><div>This meta-analysis evaluates the relationship between atherogenic indices and MDD/BD, while identifying the most effective atherogenic biomarker.</div></div><div><h3>Methods</h3><div>This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched electronic databases, including PubMed, Google Scholar, and Web of Science, for articles published up to August 1, 2024.</div></div><div><h3>Results</h3><div>We included 85 eligible studies (14 on BD and 71 on MDD), covering 70,856 participants: 18,738 patients and 52,118 healthy controls. MDD/BD patients showed significant increases (p &lt; 0.001) in the Castelli Risk Index 2 (CRI2), Atherogenic Index of Plasma (AIP), and (triglyceride or TG + low-density lipoprotein + very low-density lipoprotein)/(high-density lipoprotein cholesterol or HDL + Apolipoprotein A or ApoA) ratio, but not CRI1 and ApoB/ApoA ratio. Significant lower HDL and lecithin: cholesterol acyltransferase activity, and higher TG levels were observed in MDD/BD patients compared with controls. There were no significant differences between MDD and BD patients. Most included studies lacked the most essential information on the inclusion and exclusion of important confounders.</div></div><div><h3>Conclusions</h3><div>AIP is the most effective atherogenicity index for mood disorders. Regular lipid profiling and metabolic syndrome screening are crucial in MDD/BD. Early intervention with lipid-lowering therapies is recommended to prevent the worsening of atherogenicity and disease progression.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106005"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levelling up the study of animal gameplay","authors":"Fay E. Clark","doi":"10.1016/j.neubiorev.2025.106016","DOIUrl":"10.1016/j.neubiorev.2025.106016","url":null,"abstract":"<div><div>Play in humans and other animals is widespread and intuitive to recognise. Creative, unstructured play is difficult to quantify, but games direct play towards a specific goal and have defined rules, mechanics and rewards. To date, games have been under-utilised in human and animal behavioural neuroscience. This review evaluates evidence that animals can play human games, including game-theory contests, tangible games, and video games. Animals can be trained to play various human games with cognitive capacities such as role adoption, rule-following and performance monitoring. Animals can make irrational gameplay decisions that jeopardise rewards and have salient emotional responses to winning and losing. Games can advance the field of behavioural neuroscience in several ways. Cognitive tasks can become more engaging and ecologically relevant by adding game elements, known as gamification. Games can be used to induce and measure more naturalistic emotional responses to the process of overcoming (progression/regression) and end state (winning/losing) of cognitive challenges. There is also scope to target specific cognitive skill deficiencies in captive animals using games. However, a recent rapid increase in computerised testing environments raises an important ethical question about the boundary between games and reality for animals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106016"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neural correlates of physical exercise-induced general cognitive gains: A systematic review and meta-analysis of functional magnetic resonance imaging studies","authors":"Geng Li ,&nbsp;Haishuo Xia ,&nbsp;Gesi Teng ,&nbsp;Antao Chen","doi":"10.1016/j.neubiorev.2025.106008","DOIUrl":"10.1016/j.neubiorev.2025.106008","url":null,"abstract":"<div><div>The general-domain effect of physical exercise-induced cognitive gains in behavioral outcomes is well-documented, but a consensus on the neural correlates remains elusive. This meta-analysis aims to identify the neural correlates of physical exercise-induced general cognitive gains by examining task-related brain activation consistently modulated by physical exercise and its relationship to those gains. Our analysis of 52 studies with 1503 participants shows that physical exercise enhances cognitive task performance (Hedges' <em>g</em> = 0.271) and consistently increases task-related brain activation primarily in the bilateral precuneus. These increases in task-related brain activation correlate positively with cognitive task performance improvements improvements. Notably, physical exercise intensity, adherence, and social environment significantly modulate task-related brain activation changes induced by physical exercise. This meta-analysis offers an unprecedented comprehensive assessment of how physical exercise modulates task-related brain activation changes, providing neural evidence to support the general-domain effects on cognitive function induced by physical exercise.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106008"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The computational perspective: A catalyst for research questions in cognitive neuroscience?","authors":"Sabrina Trapp ,&nbsp;David Whitney ,&nbsp;David Pascucci","doi":"10.1016/j.neubiorev.2024.105966","DOIUrl":"10.1016/j.neubiorev.2024.105966","url":null,"abstract":"<div><div>Where do novel research questions come from? We suggest that identifying key computational problems and comparing solutions across domains can be one source. We exemplify this by looking at perception and action and outline how findings from one domain may generate novel research avenues in the other.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105966"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic basis of cancer-related fatigue","authors":"Robert Dantzer ,&nbsp;Brandon Chelette ,&nbsp;Elisabeth G. Vichaya ,&nbsp;A. Phillip West ,&nbsp;Aaron Grossberg","doi":"10.1016/j.neubiorev.2025.106035","DOIUrl":"10.1016/j.neubiorev.2025.106035","url":null,"abstract":"<div><div>Although we are all familiar with the sensation of fatigue, there are still profound divergences on what it represents and its mechanisms. Fatigue can take various forms depending on the condition in which it develops. Cancer-related fatigue is considered a symptom of exhaustion that is often present at the time of diagnosis, increases in intensity during cancer therapy, and does not always recede after completion of treatment. It is usually attributed to the inflammation induced by damage-associated molecular patterns released by tumor cells during cancer progression and in response to its treatment. In this review, we argue that it is necessary to go beyond the symptoms of fatigue to understand its nature and mechanisms. We propose to consider fatigue as a psychobiological process that regulates the behavioral activities an organism engages in to satisfy its needs, according to its physical ability to do so and to the capacity of its intermediary metabolism to exploit the resources procured by these activities. This last aspect is critical as it implies that these metabolic aspects need to be considered to understand fatigue. Based on the findings we have accumulated over several years of studying fatigue in diverse murine models of cancer, we show that energy metabolism plays a key role in the development and persistence of this condition. Cancer-related fatigue is dependent on the energy requirements of the tumor and the negative impact of cancer therapy on the mitochondrial function of the host. When inflammation is present, it adds to the organism’s energy expenses. The organism needs to adjust its metabolism to the different forms of cellular stress it experiences thanks to specialized communication factors known as mitokines that act locally and at a distance from the cells in which they are produced. They induce the subjective, behavioral, and metabolic components of fatigue by acting in the brain. Therefore, the targeting of mitokines and their brain receptors offers a window of opportunity to treat fatigue when it is no longer adaptive but an obstacle to the quality of life of cancer survivors.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106035"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relational neuroscience: Insights from hyperscanning research","authors":"Sara De Felice ,&nbsp;Tara Chand ,&nbsp;Ilona Croy ,&nbsp;Veronika Engert ,&nbsp;Pavel Goldstein ,&nbsp;Clay B. Holroyd ,&nbsp;Peter Kirsch ,&nbsp;Sören Krach ,&nbsp;Yina Ma ,&nbsp;Dirk Scheele ,&nbsp;Matthias Schurz ,&nbsp;Stefan R. Schweinberger ,&nbsp;Stefanie Hoehl ,&nbsp;Pascal Vrticka","doi":"10.1016/j.neubiorev.2024.105979","DOIUrl":"10.1016/j.neubiorev.2024.105979","url":null,"abstract":"<div><div>Humans are highly social, typically without this ability requiring noticeable efforts. Yet, such social fluency poses challenges both for the human brain to compute and for scientists to study. Over the last few decades, neuroscientific research of human sociality has witnessed a shift in focus from single-brain analysis to complex dynamics occurring across several brains, posing questions about what these dynamics mean and how they relate to multifaceted behavioural models. We propose the term ‘<em>Relational Neuroscience</em>’ to collate the interdisciplinary research field devoted to modelling the inter-brain dynamics subserving human connections, spanning from real-time joint experiences to long-term social bonds. Hyperscanning, i.e., simultaneously measuring brain activity from multiple individuals, has proven to be a highly promising technique to investigate inter-brain dynamics. Here, we discuss how hyperscanning can help investigate questions within the field of Relational Neuroscience, considering a variety of subfields, including cooperative interactions in dyads and groups, empathy, attachment and bonding, and developmental neuroscience. While presenting Relational Neuroscience in the light of hyperscanning, our discussion also takes into account behaviour, physiology and endocrinology to properly interpret inter-brain dynamics within social contexts. We consider the strengths but also the limitations and caveats of hyperscanning to answer questions about interacting people. The aim is to provide an integrative framework for future work to build better theories across a variety of contexts and research subfields to model human sociality.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105979"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the connectivity of the paraventricular nucleus of the thalamus and its position within limbic corticostriatal circuits","authors":"Gilbert J. Kirouac","doi":"10.1016/j.neubiorev.2024.105989","DOIUrl":"10.1016/j.neubiorev.2024.105989","url":null,"abstract":"<div><div>The paraventricular nucleus of the thalamus (PVT) is generating interest because evidence establishes a role for this midline thalamic nucleus in behavior. Early tracing studies demonstrated that afferent fibers from the PVT and limbic cortex converge with dopamine fibers within subcompartments of the ventral striatum. Subsequent tracing studies expanded on these observations by establishing that the PVT provides a dense projection to a continuum of striatal-like regions that include the nucleus accumbens and the extended amygdala. These findings have been complemented by recent tracing evidence examining the organization of the PVT’s efferent and afferent connections. An updated view of the organization of projection neurons in PVT is provided with a focus on the input-output relationship of these neurons. The review emphasizes recent findings demonstrating that the PVT is composed of intermixed populations of neurons with axons that collateralize to densely innervate limbic striatal regions while being reciprocally connected with limbic cortical areas that innervate the same regions of the striatum. An updated perspective of the PVT’s anatomical relationship with limbic corticostriatal circuits is presented to stimulate research on how the PVT regulates behavioral responses associated with emotion and motivation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105989"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}