Neuroscience and Biobehavioral Reviews最新文献

{"title":"An item-level systematic review of the presentation of ADHD in females","authors":"Tamara Williams ,&nbsp;Louise Horstmann ,&nbsp;Laiba Kayani ,&nbsp;Annabelle Xiao Hui Lim ,&nbsp;Abigail Russell ,&nbsp;Tamsin Ford ,&nbsp;Ann John ,&nbsp;Kapil Sayal ,&nbsp;Anita Thapar ,&nbsp;Kate Langley ,&nbsp;Joanna Martin","doi":"10.1016/j.neubiorev.2025.106064","DOIUrl":"10.1016/j.neubiorev.2025.106064","url":null,"abstract":"<div><div>Previous studies examining sex differences in attention deficit hyperactivity disorder (ADHD) have primarily examined total or subscale scores. This systematic review aimed to examine which symptoms contribute to the female presentation of ADHD at an item-level. Six research literature databases were searched for studies comparing ADHD symptoms and their impact at an item-level in females with ADHD compared with: 1) males with ADHD and 2) females without ADHD. Thirteen studies were included. In childhood, females were more likely to display the symptoms ‘fails to sustain attention in tasks’ and ‘often easily distracted’, whereas males were more likely to display the symptoms ‘often fidgets’, ‘difficulty remaining seated when required’, ‘runs/climbs in situations when inappropriate’, ‘always on the go’, ‘often noisy in playing’, ‘difficulty waiting turn’, ‘often blurts out answers’ and ‘often interrupts others’. In adulthood, females were more likely to endorse the symptoms ‘easily distracted’, ‘difficulty organising tasks’, ‘blurts out answers’ and ‘talks excessively’, as well as to report mind wandering and adverse home impacts. Females with ADHD differ in their symptom profile to males with ADHD, highlighting the need for future research to identify and characterise symptoms typical of female ADHD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"171 ","pages":"Article 106064"},"PeriodicalIF":7.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical and horizontal space-valence associations: A meta-analysis","authors":"Jan Pohl ,&nbsp;Alex Miklashevsky","doi":"10.1016/j.neubiorev.2025.106054","DOIUrl":"10.1016/j.neubiorev.2025.106054","url":null,"abstract":"<div><div>Previous research found associations between lower vs. upper space and negative vs. positive stimuli correspondingly (vertical Space-Valence Associations, SVAs) and between the left vs. right side and negative vs. positive stimuli correspondingly (horizontal SVAs). We conducted a comprehensive meta-analysis of SVAs for both dimensions in behavioral studies. We tested the robustness of SVAs and examined factors potentially modulating them: participants’ culture, handedness, gender, age, the exact valence domain under study, the experimental task, type of stimuli, publication year, and statistics used. Articles were extracted from Web of Science, PubMed, and ScienceDirect in February 2021. Overall, 91 articles with 199 experiments and 21,951 participants were included in the final analysis.</div><div>We found robust evidence of SVAs in vertical (<em>r</em> = .440, <em>k</em> = 111 experiments) and horizontal dimensions (<em>r</em> = .310; <em>k</em> = 88 experiments), with little evidence for literature biases. The distribution of effect sizes was highly heterogeneous, even after subgroup analyses, which indicates unidentified factors varying across studies. Experiments on vertical SVAs explicitly asking participants to evaluate valence showed larger effect sizes than experiments where valence remained task-irrelevant. There was a robust effect of handedness on horizontal SVAs: Participants associated positive stimuli with the side of their dominant hand. There was also some evidence of cultural influences on the horizontal SVAs.</div><div>Overall, our meta-analysis revealed a hierarchy of factors modulating activation of SVAs, which includes both situated and embodied factors. It is, therefore, essential to focus on specific concept categories and contexts rather than consider abstract concepts in general.</div></div><div><h3>Public significance statement</h3><div>This meta-analysis revealed medium effects of space-valence associations: Upper/right space is associated with positive and lower/right space with negative concepts. On the vertical dimension, this effect is modulated by valence being task-relevant, e.g., directly asking people about valence results in stronger associations. For the horizontal dimension, left-handers robustly showed a reversed effect (i.e., left is good); horizontal space-valence associations might be even stronger in non-Western countries.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106054"},"PeriodicalIF":7.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis","authors":"Annelies Dellink ,&nbsp;Gertjan Vanderhaegen ,&nbsp;Violette Coppens ,&nbsp;Karen M. Ryan ,&nbsp;Declan M. McLoughlin ,&nbsp;Jennifer Kruse ,&nbsp;Eric van Exel ,&nbsp;Linda van Diermen ,&nbsp;Jean-Baptiste Belge ,&nbsp;Tore Ivar Malmei Aarsland ,&nbsp;Manuel Morrens","doi":"10.1016/j.neubiorev.2025.106060","DOIUrl":"10.1016/j.neubiorev.2025.106060","url":null,"abstract":"<div><div>Electroconvulsive therapy (ECT) is an effective intervention for severe unipolar and bipolar depression, yet its drawbacks often lead to its underutilization. Accurate prediction of ECT outcomes is crucial for optimizing patient care and increasing remission rates. This study synthesized existing evidence on the relationship between baseline inflammatory markers and ECT outcomes. Additionally, we explored whether changes in these markers during ECT correlated with symptom improvement. A correlation meta-analysis was conducted according to the PRISMA statement, including a total of fourteen studies (n = 556 patients). The analyses revealed that higher baseline CRP and IL-6 levels were significantly associated with greater depressive symptom reduction post-ECT. Additionally, our findings suggested that increases in kynurenine metabolites and IL-8 during treatment correlated with improved depressive symptoms, offering insights into the mechanistic aspects of depression and ECT. In conclusion, peripheral inflammation in depression, as measured by CRP and IL-6, is associated with better ECT outcomes and may guide treatment stratification. Further research on a broader range of cytokines and kynurenine metabolites is needed to confirm these findings.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106060"},"PeriodicalIF":7.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking the complexities of consciousness: Theories and reflections","authors":"Liad Mudrik ,&nbsp;Melanie Boly ,&nbsp;Stanislas Dehaene ,&nbsp;Stephen M. Fleming ,&nbsp;Victor Lamme ,&nbsp;Anil Seth ,&nbsp;Lucia Melloni","doi":"10.1016/j.neubiorev.2025.106053","DOIUrl":"10.1016/j.neubiorev.2025.106053","url":null,"abstract":"<div><div>As the field of consciousness science matures, the research agenda has expanded from an initial focus on the neural correlates of consciousness, to developing and testing theories of consciousness. Several theories have been put forward, each aiming to elucidate the relationship between consciousness and brain function. However, there is an ongoing, intense debate regarding whether these theories examine the same phenomenon. And, despite ongoing research efforts, it seems like the field has so far failed to converge around any single theory, and instead exhibits significant polarization. To advance this discussion, proponents of five prominent theories of consciousness—Global Neuronal Workspace Theory (GNWT), Higher-Order Theories (HOT), Integrated Information Theory (IIT), Recurrent Processing Theory (RPT), and Predictive Processing (PP)—engaged in a public debate in 2022, as part of the annual meeting of the Association for the Scientific Study of Consciousness (ASSC). They were invited to clarify the explananda of their theories, articulate the core mechanisms underpinning the corresponding explanations, and outline their foundational premises. This was followed by an open discussion that delved into the testability of these theories, potential evidence that could refute them, and areas of consensus and disagreement. Most importantly, the debate demonstrated that at this stage, there is more controversy than agreement between the theories, pertaining to the most basic questions of what consciousness is, how to identify conscious states, and what is required from any theory of consciousness. Addressing these core questions is crucial for advancing the field towards a deeper understanding and comparison of competing theories.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106053"},"PeriodicalIF":7.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing zebrafish models of Notch-related CNS pathologies","authors":"Natalia Erofeeva ,&nbsp;David S. Galstyan ,&nbsp;Longen Yang ,&nbsp;Tatiana Strekalova ,&nbsp;Lee Wei Lim ,&nbsp;Murilo S. de Abreu ,&nbsp;Nikita I. Golushko ,&nbsp;Adam Michael Stewart ,&nbsp;Allan V. Kalueff","doi":"10.1016/j.neubiorev.2025.106059","DOIUrl":"10.1016/j.neubiorev.2025.106059","url":null,"abstract":"<div><div>Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (<em>Danio rerio</em>). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106059"},"PeriodicalIF":7.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpersonal synchronization: An overlooked factor in development, social cognition, and psychopathology","authors":"Jessica Fattal,&nbsp;Dan P. McAdams,&nbsp;Vijay A. Mittal","doi":"10.1016/j.neubiorev.2025.106037","DOIUrl":"10.1016/j.neubiorev.2025.106037","url":null,"abstract":"<div><div>Intact social functioning relies on a combination of explicit and implicit behavioral, attentional, and interpersonal processes referred to as “social cognition”. Characterizing these interpersonal processes forms a critical underpinning to understanding and treating psychopathology, particularly in disorders where deficits in social functioning do not emerge as a secondary symptom but rather as an essential feature of the disorder. Two of such disorders are autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SZ). However, despite the substantial overlap in the features of social dysfunction between ASD and SZ, including social cognitive deficits in theory of mind, perspective-taking, and empathy, there is a limited understanding of the mechanisms underlying those shared deficits, and how to treat them. We suggest that disruptions of interpersonal functioning emerge over the course of development, and that interpersonal synchronization, a phenomenon in which behavioral and physiological cues align between interacting partners, forms a critical component of social cognition that underlies the disruption in social functioning in ASD and SZ. We present a conceptual review of typical and atypical development of social processes and highlight the role of interpersonal synchronization across the course of development. Then, we review the existing evidence suggesting impairments in both the intentional and spontaneous synchronization of interpersonal processes in ASD and SZ, as well as studies suggesting that interpersonal synchronization and clinical symptoms may be improved through body-oriented interventions within these disorders. Finally, we suggest potential mechanisms that may underpin typical and atypical development of interpersonal synchronization.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106037"},"PeriodicalIF":7.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The resurgence of synthetic cannabinoid receptor agonists as adulterants in the Era of Cannabis legalization: Lessons from prior epidemics and clinical implications","authors":"Austin T. Jones ,&nbsp;Alaa Marwan Abu Taha ,&nbsp;Grover P. Miller","doi":"10.1016/j.neubiorev.2025.106043","DOIUrl":"10.1016/j.neubiorev.2025.106043","url":null,"abstract":"<div><div>Momentum towards legalization of medical and recreational cannabis drives a convergence between natural cannabinoids and their synthetic counterparts, creating new clinical challenges in a second wave of exposures. This review critically examines the emerging challenges posed by synthetic cannabinoid receptor agonists (SCRAs) and semi-synthetic cannabinoids, emphasizing their clinical implications. SCRAs are potent full agonist activity that have been identified as adulterants in several recreational substances, including cannabis and opioids. Adulteration often leads to unpredictable clinical outcomes and exacerbates the potential for drug interactions. Drawing parallels with other drug epidemics, this paper highlights the urgent need for clinical preparedness to address the nuanced presentations of cannabinoid toxicity, stressing the importance of patient history, physical examination, and judicious use of supportive laboratory tests. This review serves as a cautionary tale and call to action for researchers and policymakers. There is a clear need for robust quality control measures, enhanced public awareness campaigns, and development of evidence-based clinical guidelines to mitigate the health risks associated with intentional and unintentional use of synthetic cannabinoids.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106043"},"PeriodicalIF":7.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal integration as an adaptive process in visual perception, attention, and working memory","authors":"Elkan G. Akyürek","doi":"10.1016/j.neubiorev.2025.106041","DOIUrl":"10.1016/j.neubiorev.2025.106041","url":null,"abstract":"<div><div>I propose that temporal integration is ubiquitous in visual perception, because it serves an adaptive role. To support this idea, I draw together evidence from historically separated research fields that target different timescales. At one extreme, this concerns the detection and discrimination of successive stimuli within intervals of less than a quarter of a second. At an intermediate level, associated with attentional episodes, intervals between half a second up to a few seconds are considered. Finally, at the other extreme, this involves high-level, conceptual events across intervals of multiple seconds or even minutes. Across such varying intervals, the nature of temporal integration and the resultant perceptual events are clearly different. I nevertheless propose that temporal integration should be understood as a continuous process that serves a common adaptive goal: To maximize the amount of useful information, at minimal costs, tailored to the observer’s current needs and circumstances. Emerging from this viewpoint are several research directions that might be pursued on the topic of temporal integration, and on its consequences for perception and memory.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106041"},"PeriodicalIF":7.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in peripheral blood metabolites and biological functions in major depressive disorder: A systematic review and meta-analysis","authors":"Zhengyang Wang ,&nbsp;Yajie Xiang ,&nbsp;Ruozhi Dang ,&nbsp;Peng Wang ,&nbsp;Xiaoyan Du ,&nbsp;Peng Xie","doi":"10.1016/j.neubiorev.2025.106052","DOIUrl":"10.1016/j.neubiorev.2025.106052","url":null,"abstract":"<div><div>To explore the sex-specific peripheral blood metabolites and biological functions altered in patients with major depressive disorder (MDD). A search was conducted on PubMed, Cochrane, Embase, Web of Science, and other databases published up to 11/2023. To maximize the search, we also reviewed systematic reviews and meta-analyses on the same topic. We included studies that conducted metabolic characterizations during current depressive episodes or after antidepressant treatments, with all data stratified by sex. Fifty-eight studies involving 83 cohorts with 5285 MDD participants were included in this meta-analysis. Random effects meta-analysis was conducted for data from ≥3 cohorts. We identified 5 sex-specific metabolites from 22 candidate peripheral blood metabolites. In males with MDD, we observed lower levels of estradiol and progesterone, alongside higher levels of androstenedione, dihydrotestosterone, and uric acid compared with female MDD patients. In addition, steroid hormone biosynthesis has been identified as a potentially sex-specific pathway. Our findings highlight significant evidence for targeting sex hormones as a broad understanding of MDD, providing potentially objective diagnostic and therapeutic insights.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106052"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural control of sex differences in affiliative and prosocial behaviors","authors":"Sanja Mikulovic ,&nbsp;Constanze Lenschow","doi":"10.1016/j.neubiorev.2025.106039","DOIUrl":"10.1016/j.neubiorev.2025.106039","url":null,"abstract":"<div><div>Social interactions are vital for various taxa and species. Prosocial and affiliative dynamics within a group and between individuals are not only pleasurable and rewarding, but also appear to actively contribute to well-being, cognitive performance, and disease prevention. Moreover, disturbances in acting or being prosocial can represent a major burden for an individual and their affective partners. These disruptions are evident across a spectrum of neuropsychiatric conditions, including depression and autism spectrum disorders. Importantly, interactive patterns of prosocial and affiliative behavior can vary with sex. The fact that genders are differentially affected by neuropsychiatric disorders associated with social impairment underscores the high importance of this research in uncovering the underlying neural correlates and mechanisms. This review focuses on elucidating sex-related differences in prosocial and affiliative behaviors and their potential association with sexually different neural correlates. Specifically, we aim to shed light on the complex interplay between sex, behavior, and neurobiology in affiliative and prosocial interaction patterns.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"171 ","pages":"Article 106039"},"PeriodicalIF":7.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}