Neuroscience and Biobehavioral Reviews最新文献

{"title":"Dementia subtypes and suicidality: A systematic review and meta-analysis","authors":"Eleanor Nuzum ,&nbsp;Radvile Medeisyte ,&nbsp;Roopal Desai ,&nbsp;Anastasia Tsipa ,&nbsp;Caroline Fearn ,&nbsp;Aphrodite Eshetu ,&nbsp;Georgina Charlesworth ,&nbsp;Gavin R. Stewart ,&nbsp;Sebastian J. Crutch ,&nbsp;Céline El Baou ,&nbsp;Suman Kurana ,&nbsp;Emilie V. Brotherhood ,&nbsp;Katie Flanagan ,&nbsp;Alberto Salmoiraghi ,&nbsp;Amy Kerti ,&nbsp;Joshua Stott ,&nbsp;Amber John","doi":"10.1016/j.neubiorev.2024.105995","DOIUrl":"10.1016/j.neubiorev.2024.105995","url":null,"abstract":"<div><h3>Aims</h3><div>Recent research has highlighted a link between dementia and increased risk of suicidal ideation, suicide attempts and suicide deaths. Understanding the relative risk of suicide between subtypes of dementia is important for services to offer appropriate intervention.</div></div><div><h3>Method</h3><div>We searched five databases from inception to July 2023 for peer-reviewed publications reporting suicidal ideation, suicide attempt or death by suicide for at least two dementia subtypes. Meta-analyses compared suicidality between subtypes of dementia with Alzheimer’s Disease (AD).</div></div><div><h3>Results</h3><div>From 4983 studies identified, 12 met inclusion criteria. Pooling data, people with Vascular Dementia were significantly more likely to experience suicidal ideation (OR= 2.02 [95 % CI= 1.06;3.8]) and attempt suicide (OR=1.94 [95 % CI= 1.28;2.94]) than people with AD, but not die by suicide (OR= 1.05 [95 % CI= 0.69;1.59]). People with Dementia with Lewy Bodies were significantly more likely to report suicidal ideation (OR= 1.56 [95 % CI= 1.09;2.23]) than AD but not attempt suicide (OR= 1.12 [95 % CI= 0.83;1.50]). People with Frontotemporal Dementia were significantly more likely to attempt suicide (OR= 2.42 [95 % CI= 1.02;5.72]) than people with AD but not report suicidal ideation (OR= 1.67 [95 % CI= 0.34;8.33]). People with Mixed Dementia were significantly more likely to attempt suicide (OR= 2.83 [95 % CI= 1.52;5.27]) than people with AD but not report suicidal ideation (OR = 1.65 [95 % CI= 0.5;5.46]).</div></div><div><h3>Conclusions</h3><div>Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105995"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive coding for social perception: Complex interactions across space and time","authors":"Kirsten Rittershofer ,&nbsp;Quirin Gehmacher ,&nbsp;Clare Press","doi":"10.1016/j.neubiorev.2024.105993","DOIUrl":"10.1016/j.neubiorev.2024.105993","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105993"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turbulence as a framework for brain dynamics in health and disease","authors":"Gustavo Deco ,&nbsp;Yonatan Sanz Perl ,&nbsp;Katarina Jerotic ,&nbsp;Anira Escrichs ,&nbsp;Morten L. Kringelbach","doi":"10.1016/j.neubiorev.2024.105988","DOIUrl":"10.1016/j.neubiorev.2024.105988","url":null,"abstract":"<div><div>Turbulence is a universal principle for fast energy and information transfer. Moving beyond the turbulence of fluid dynamics, turbulence has recently been demonstrated in brain dynamics. Importantly, turbulence can be expressed as the rich variability across spacetime of the local levels of synchronisation of coupled brain signals. In fact, the optimal mixing properties of turbulence is what allows for efficient transfer of energy/information over space and time in the brain. This is especially important for survival given the need to overcome the inherent slowness in neural dynamics. Here, we review the research showing that the turbulence offers a convenient framework for describing brain dynamics and that the scale-free nature of turbulence, reflected in power-laws, provides the necessary mechanisms for time-critical information transfer in the brain. Whole-brain modelling of turbulence as coupled-oscillators has been shown to provide precise signatures of many different brain states. The levels of turbulence change in disease, and careful research of the vortex space could potentially help discover new avenues for a better understanding of this breakdown and offer better control of these highly non-linear, non-equilibrium states. Overall, the framework of the turbulent brain is a highly fertile, fast developing field with great potential.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105988"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of the motor impairments in autism spectrum disorder","authors":"Samara Helena da Silva ,&nbsp;Matheus Ribeiro Felippin ,&nbsp;Letícia de Oliveira Medeiros ,&nbsp;Cecília Hedin-Pereira ,&nbsp;Anaelli Aparecida Nogueira-Campos","doi":"10.1016/j.neubiorev.2025.106002","DOIUrl":"10.1016/j.neubiorev.2025.106002","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder mainly defined by impairments in communication and socialization. Although motor symptoms are not typically considered central to the disease, their high frequency and early onset have been recurrently reported in the literature. Therefore, this scoping review provides a broad description of these motor impairments across all ages, as well as a discussion of their relevance and relation to other clinical aspects of ASD. The scientific search was carried out in Scopus, Pubmed, Embase, and Web of Science databases. Nineteen studies were selected after applying the eligibility criteria. The studies analyzed 784 participants diagnosed with ASD compared to 540 controls. Motor function was assessed by means of varied kinds of scales and questionnaires. The main motor domains evaluated included features of fine and gross motor skills, manual dexterity, coordination/motor control/praxis, balance, running speed/agility, strength, gait, whole-body movements, aiming and catching (ball skills), and repetitive movements. Motor impairments are consistently observed in ASD from the first years of life, persisting into adulthood. It includes a significant deficit in performance of manual, posture, strength, and gait behavior/skills. The deficits described in ASD comprised impairments in fine and gross motor skills, lower balance, lower cadence, and greater variation of gait control, as well as weakness among other features that leads this population to move in an adaptive way affecting their interactions in real life.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106002"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unconscious will as a neurobehavioral mechanism against adversity","authors":"Patrick Anselme","doi":"10.1016/j.neubiorev.2024.105985","DOIUrl":"10.1016/j.neubiorev.2024.105985","url":null,"abstract":"<div><div>Incentive salience theory both explains the directional component of motivation (in terms of cue attraction or “wanting”) and its energetic component, as a function of the strength of cue attraction. This theory characterizes cue- and reward-triggered approach behavior. But it does not tell us how behavior can show enhanced vigor under reward uncertainty, when cues are inconsistent or resources hidden. Reinforcement theory is also ineffective in explaining enhanced vigor in case reward expectation is low or nil. This paper provides a neurobehavioral interpretation of effort in situations of adversity (which always include some uncertainty about outcomes) that is complementary to the attribution of incentive salience to environmental cues. It is argued that manageable environmental challenges activate an unconscious process of self-determination to achieve “wanted” actions. This unconscious process is referred to as incentive effort, which involves the hypothalamo-pituitary-adrenal (HPA) axis, noradrenaline, as well as striatal dopamine. Concretely, HPA-induced dopamine release would have the function to make effort—or effortful actions—“wanted” in a challenging context, in which the environmental cues are poorly predictive of reward—i.e., unattractive. Stress would only emerge in the presence of unmanageable challenges. It is hypothesized that incentive effort is the core psychological basis of will—and is, for this reason, termed “willing.”</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105985"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared molecular signature in Alzheimer's disease and schizophrenia: A systematic review of the reelin signaling pathway","authors":"Ana Isabel Valderrama-Mantilla ,&nbsp;Celia Martín-Cuevas ,&nbsp;Ana Gómez-Garrido ,&nbsp;Cristina Morente-Montilla ,&nbsp;Benedicto Crespo-Facorro ,&nbsp;Susana García-Cerro","doi":"10.1016/j.neubiorev.2025.106032","DOIUrl":"10.1016/j.neubiorev.2025.106032","url":null,"abstract":"<div><div>The Reelin signaling pathway, particularly the <em>RELN-APOER2-DAB1</em> complex, has emerged as a key contributor to the neuropathology of Alzheimer’s disease (AD) and Schizophrenia (SZ). Despite being distinct clinical conditions, these disorders exhibit similar patterns of cognitive decline, including early disruptions in synaptic function and memory impairments. Notably, individuals with SZ have a 2–4 fold increased risk of developing AD or other dementias, highlighting potential shared molecular mechanisms, and positioning Reelin as a pivotal link between them. This systematic review explores the role of Reelin and its signaling components across these disorders. In AD, Reelin disruption correlates with hallmark features such as Tau hyperphosphorylation, amyloid-beta accumulation, and cognitive deficits. In SZ, alterations in Reelin signaling, including epigenetic modifications affecting <em>RELN</em> expression, are linked to disruptions in neuronal development and synaptic plasticity, particularly in the parietal and prefrontal cortices. Additionally, genomic studies reveal specific <em>RELN</em> variants and allelic imbalances that may influence disease severity and treatment response in SZ, suggesting <em>RELN</em>’s role as a potential biomarker for therapeutic outcomes. Region-specific Reelin alterations in both AD and SZ suggest differing impacts yet underscore a potential common molecular origin. Our findings highlight the Reelin pathway as a molecular convergence point, warranting further investigation as a therapeutic and diagnostic target for AD, SZ, and potentially other neuropsychiatric disorders. The interplay between genetic and epigenetic regulation of <em>RELN</em> may provide novel insights into neurodegeneration, with implications for personalized intervention strategies in AD and SZ.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106032"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Play makes us human. Commentary on adult and juvenile play in humans and other primates","authors":"Peter Gray","doi":"10.1016/j.neubiorev.2024.105981","DOIUrl":"10.1016/j.neubiorev.2024.105981","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105981"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological insights into Alzheimer's disease: A review of human and animal studies","authors":"Kirsten N. Calvin-Dunn ,&nbsp;Adam Mcneela ,&nbsp;A. Leisgang Osse ,&nbsp;G. Bhasin ,&nbsp;M. Ridenour ,&nbsp;J.W. Kinney ,&nbsp;J.M. Hyman","doi":"10.1016/j.neubiorev.2024.105987","DOIUrl":"10.1016/j.neubiorev.2024.105987","url":null,"abstract":"<div><div>This review highlights the crucial role of neuroelectrophysiology in illuminating the mechanisms underlying Alzheimer's disease (AD) pathogenesis and progression, emphasizing its potential to inform the development of effective treatments. Electrophysiological techniques provide unparalleled precision in exploring the intricate networks affected by AD, offering insights into the synaptic dysfunction, network alterations, and oscillatory abnormalities that characterize the disease. We discuss a range of electrophysiological methods, from non-invasive clinical techniques like electroencephalography and magnetoencephalography to invasive recordings in animal models. By drawing on findings from these studies, we demonstrate how electrophysiological research has deepened our understanding of AD-related network disruptions, paving the way for targeted therapeutic interventions. Moreover, we underscore the potential of electrophysiological modalities to play a pivotal role in evaluating treatment efficacy. Integrating electrophysiological data with clinical neuroimaging and longitudinal studies holds promise for a more comprehensive understanding of AD, enabling early detection and the development of personalized treatment strategies. This expanded research landscape offers new avenues for unraveling the complexities of AD and advancing therapeutic approaches.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105987"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does neurochemistry affect attachment styles in humans? The role of oxytocin and the endogenous opioid system in sociotropy and autonomy – A systematic review","authors":"Anita Snowdon-Farrell ,&nbsp;Chiara Attal ,&nbsp;Naghmeh Nikkheslat ,&nbsp;Carmine Pariante ,&nbsp;Allan H. Young ,&nbsp;Roland Zahn","doi":"10.1016/j.neubiorev.2024.105994","DOIUrl":"10.1016/j.neubiorev.2024.105994","url":null,"abstract":"<div><div>Oxytocin was hypothesised to play a critical role in forming and maintaining secure attachments, shown to confer resilience against affective disorders. The endogenous opioid system has also emerged as a key player in attachment dynamics. In this pre-registered systematic review, we investigated whether individual differences in the functioning of these neurochemical systems are related to attachment styles, following PRISMA guidelines. As predicted, individuals with higher oxytocin function exhibited more secure attachment styles (p = .006, n = 12 studies) and less insecure attachment styles (p = .021, n = 16 studies). Contrary to our hypothesis, we found no association of endogenous opioid function with insecure (p = 0.549, n = 11 studies) or secure attachment styles (p = .065, n = 11 studies). The lack of association between endogenous mu-opioid function and attachment styles remains inconclusive due to inconsistencies in the neurochemical measurements and lack of eligible studies. Therefore, further investigations into the role of the endogenous opioid system in attachment styles are needed. Our findings corroborate the hypothesis that individual differences in oxytocin function relate to differences in attachment styles.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105994"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory testing in infants with perinatal asphyxia: Enhancing encephalopathy risk stratification for future health outcomes","authors":"Serafina Perrone ,&nbsp;Virginia Beretta ,&nbsp;Maria Luisa Tataranno ,&nbsp;Sidhartha Tan ,&nbsp;Zhongjie Shi ,&nbsp;Elena Scarpa ,&nbsp;Valentina Dell’Orto ,&nbsp;Sebastiano Ravenda ,&nbsp;Chiara Petrolini ,&nbsp;Maria Maddalena Brambilla ,&nbsp;Paola Palanza ,&nbsp;Eloisa Gitto ,&nbsp;Francesco Nonnis-Marzano","doi":"10.1016/j.neubiorev.2025.106029","DOIUrl":"10.1016/j.neubiorev.2025.106029","url":null,"abstract":"<div><div>Perinatal asphyxia (PA) is a leading cause of neonatal morbidity and mortality, often resulting in long-term neurodevelopmental challenges. Despite advancements in perinatal care, predicting long-term outcomes remains difficult. Early diagnosis is essential for timely interventions to reduce brain injury, with tools such as Magnetic Resonance Imaging, brain ultrasound, and emerging biomarkers playing a possible key role. Olfaction, one of the earliest senses to develop, may provide valuable insights into long-term neurodevelopmental outcomes following PA due to its intricate neural connections with regions responsible for memory, emotion, and homeostasis. Newborns demonstrate early olfactory abilities, such as recognizing maternal odors, which are vital for bonding, feeding, and emotional regulation. These responses are processed by a network of brain regions, including the olfactory bulb (OB), piriform cortex, amygdala, and orbitofrontal cortex. Hypoxic injury to these regions, particularly the OB, may disrupt olfactory processing in infants with PA, potentially affecting their cognitive and social development. Investigating the relationship between olfactory system development and perinatal brain injury could lead to innovative diagnostic and therapeutic approaches. Further research, including clinical and animal studies, is necessary to fully explore the potential of olfactory assessments in predicting outcomes after PA. This educational review explores and discusses the potential of olfaction as a predictor of long-term outcomes and a tool for risk stratification following PA, opening new pathways for interventions and improved care.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106029"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}