Neuroscience and Biobehavioral Reviews最新文献_第8页

Psychiatric comorbidity in substance use disorders, a systematic review of neuro-imaging findings 物质使用障碍的精神共病，神经影像学发现的系统回顾

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-12 DOI: 10.1016/j.neubiorev.2025.106325

Debbie R.M. Tesselaar , Arnt F.A. Schellekens , Judith R. Homberg , Jan Booij , Cyprien Guerrin

{"title":"Psychiatric comorbidity in substance use disorders, a systematic review of neuro-imaging findings","authors":"Debbie R.M. Tesselaar , Arnt F.A. Schellekens , Judith R. Homberg , Jan Booij , Cyprien Guerrin","doi":"10.1016/j.neubiorev.2025.106325","DOIUrl":"10.1016/j.neubiorev.2025.106325","url":null,"abstract":"<div><div>Substance use disorder (SUD) have negative consequences for affected individuals and society. Current treatments are moderately effective, partly due to the large heterogeneity in SUDs, including co-occurring psychopathology. A better understanding of the mechanisms underlying these frequently co-occurring psychiatric conditions is required to develop individualized treatments to increase treatment success rates. We systematically reviewed case-control studies investigating neurobiological differences measured using neuroimaging between participants with SUD only and participants with SUD and co-occurring psychiatric disorders. We searched articles in four databases. Inclusion criteria further existed of an ICD and/or DSM diagnoses based on interview assessment or Fagerström test for Nicotine Dependence scores ≥ 5. We hypothesised that co-occurring psychopathology could (1) amplify the neurobiological effects of SUD, (2) attenuate it, (3) have unique neurobiological effects, or (4) have no additional neurobiological effects. From 10,076 unique records screened, we included a total of 26 articles investigating the effect of personality disorder cluster B and/or C (6), depression (4), PTSD (4), ADHD (4), schizophrenia (8), bipolar disorder (1) or anxiety disorders (1) on SUD. We found amplifying effects of co-occurring schizophrenia and personality disorder, unique effects of schizophrenia, ADHD and personality disorder, and attenuating or no effect of depression on SUD. Findings on PTSD were contradictory. In conclusion, different co-occurring psychiatric disorder have distinct effects on the neurobiology of SUD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106325"},"PeriodicalIF":7.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches to map cortical excitability beyond the primary motor cortex – Perspectives from cognitive neuroscience, multimodal imaging and clinical applications 从认知神经科学、多模态成像和临床应用的角度研究初级运动皮层以外的皮层兴奋性。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-12 DOI: 10.1016/j.neubiorev.2025.106338

Anna-Lisa Schuler , Martin Tik , Elisa Kallioniemi , Ana Suller Marti , Zhengchen Cai , Giovanni Pellegrino

{"title":"Approaches to map cortical excitability beyond the primary motor cortex – Perspectives from cognitive neuroscience, multimodal imaging and clinical applications","authors":"Anna-Lisa Schuler , Martin Tik , Elisa Kallioniemi , Ana Suller Marti , Zhengchen Cai , Giovanni Pellegrino","doi":"10.1016/j.neubiorev.2025.106338","DOIUrl":"10.1016/j.neubiorev.2025.106338","url":null,"abstract":"<div><div>Excitability is a neuronal property quantified as the magnitude of neural response to stimuli. It plays a crucial role in information processing and is disrupted in various neuropsychiatric conditions. In humans, non-invasive measurements of brain excitability have been mostly limited to the primary motor cortex. Here, the response to Transcranial Magnetic Stimulation (TMS) is quantified as the magnitude of the muscular contraction. TMS mapping of brain excitability outside the motor cortex, simultaneously across brain areas, and in deep regions is challenging. Indeed, TMS has little depth penetration, and can only probe one cortical point at a time. Furthermore, the measurement of the responses to stimuli outside the motor cortex requires simultaneous neuroimaging, such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Possible solutions include the application of stimulation approaches alternative to TMS, and the investigation of resting state properties of electromagnetic and hemodynamic brain activity. We show that, in combination with TMS or alone, neuroimaging will progressively allow non-invasive and accurate mapping of excitability with high spatio-temporal resolution, across the entire brain, and non-invasively. This will mark a critical advancement for stimulation thresholding in basic neuroscience and clinical medicine, as well as diagnostics of deviant excitability patterns in neuropsychiatric conditions. It is the aim of this review to critically discuss the state-of-the-art of whole brain excitability mapping and provide an outlook on neuroscience and clinical implications.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106338"},"PeriodicalIF":7.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “An ALE meta-analysis of pain processing alterations in fibromyalgia: Toward an evidence-based process model” [Neurosci. Biobehav. Rev. 176 (2025) 106303] “纤维肌痛症疼痛处理改变的ALE荟萃分析：循证过程模型”的更正[神经科学]。Biobehav。Rev. 176(2025) 106303]。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-09 DOI: 10.1016/j.neubiorev.2025.106321

Marco Cavicchioli , Alberto Caruso , Andrea Scalabrini , Alessandro Torelli , Sara Bottiroli , Anna Pichiecchio , Elena Prodi , Martina Cangelosi , Carlo Lai , Paolo Vitali , Luca Maria Sconfienza , Piercarlo Sarzi-Puttini , Federica Galli

引用次数: 0

Linguistic structure as a guiding principle for human neuroscience 语言结构作为人类神经科学的指导原则。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-06 DOI: 10.1016/j.neubiorev.2025.106322

Anna Mai , Andrea E. Martin

引用次数: 0

A systematic review and meta-analysis of sex differences in the relationship between cardiac interoceptive accuracy and emotion 心脏内感受准确度与情绪关系性别差异的系统回顾与meta分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106318

Sarina Afzali Shamsabad , Alexandra Edwards , Rebecca Brewer , Jennifer Murphy

{"title":"A systematic review and meta-analysis of sex differences in the relationship between cardiac interoceptive accuracy and emotion","authors":"Sarina Afzali Shamsabad , Alexandra Edwards , Rebecca Brewer , Jennifer Murphy","doi":"10.1016/j.neubiorev.2025.106318","DOIUrl":"10.1016/j.neubiorev.2025.106318","url":null,"abstract":"<div><div>Interoceptive accuracy, the ability to correctly perceive internal bodily signals, is considered integral to emotional experience. However, surprising evidence suggests that whilst females tend to have poorer interoceptive accuracy than males, they tend to have better emotion processing ability and rate their emotional competence higher. The current systematic review and meta-analysis aimed to investigate sex differences in the relationship between cardiac interoceptive accuracy and emotion. A review of three databases (PsychInfo, Web of Science, PubMed) yielded 2707 abstracts, resulting in 94 eligible studies. Authors of eligible studies were contacted for sex disaggregated summary statistics. 33 and 30 studies were included in the qualitative and quantitative synthesis, respectively. Overall, we found little evidence of a relationship between cardiac interoceptive accuracy and measures of emotion when examining pooled groups and after sex disaggregation. These results question the proposal that cardiac interoceptive accuracy, as routinely measured, relates to emotion. The implications of these results are discussed considering limitations of our current measures of cardiac interoceptive accuracy and emotion.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106318"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of social determinants of health on cortisol response among informal caregivers in Organization for Economic Cooperation and Development countries: A systematic review 经济合作与发展组织国家非正式照顾者健康社会决定因素对皮质醇反应的影响：一项系统综述。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106302

Zilin Li , Sophie Luo , Amélie Quesnel-Vallée

{"title":"Impacts of social determinants of health on cortisol response among informal caregivers in Organization for Economic Cooperation and Development countries: A systematic review","authors":"Zilin Li , Sophie Luo , Amélie Quesnel-Vallée","doi":"10.1016/j.neubiorev.2025.106302","DOIUrl":"10.1016/j.neubiorev.2025.106302","url":null,"abstract":"<div><h3>Objectives</h3><div>As global populations age, the role of informal caregivers has gained increasing importance. However, caregiving is often a source of sustained stress that can lead to adverse mental, emotional, and physiological changes. The physiological impact of caregiving stress may vary according to social determinants of health (SDOH). We need to advance our understanding of these variations to inform equitable and targeted policies and interventions.</div></div><div><h3>Methods</h3><div>Using the PROGRESS-Plus framework, we systematically review research examining how SDOH influence cortisol responses among informal caregivers. We synthesize findings from quantitative studies conducted in member countries of the Organization for Economic Co-operation and Development with a systematic search in MEDLINE, EMBASE, and PsycINFO, identifying 624 records, of which 18 met the inclusion criteria.</div></div><div><h3>Results</h3><div>Findings across most SDOH dimensions were inconclusive. Mixed results were observed for the effects of gender and occupation. Although the significance levels varied, lower-income and older caregivers generally exhibited elevated cortisol levels, suggesting higher physiological stress, while social support can buffer the impact of caregiving stress on cortisol regulation. More consistent findings emerged for ethnicity, education, and psychosocial factors; however, studies addressing these dimensions were limited.</div></div><div><h3>Conclusion</h3><div>Variations in results may stem from small, non-representative samples, diverse study contexts, and cortisol measurement methods. Additionally, caregiving is a multifaceted activity influenced by various factors, underscoring the need for intersectional investigations that examine multiple SDOHs.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106302"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Religious and spiritual experiences from a neuroscientific and complex systems perspective 从神经科学和复杂系统的角度看宗教和精神体验。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106319

Peter Jedlicka , Martha Nari Havenith

{"title":"Religious and spiritual experiences from a neuroscientific and complex systems perspective","authors":"Peter Jedlicka , Martha Nari Havenith","doi":"10.1016/j.neubiorev.2025.106319","DOIUrl":"10.1016/j.neubiorev.2025.106319","url":null,"abstract":"<div><div>The emergence of spiritual and religious practices can be seen as a major cognitive transition in the evolution of biological organisms. Spiritual and religious experiences are closely linked to evolved complex brain structures, as well as their dynamics and plasticity. In this review, we will focus on the neural mechanisms that make such experiences possible. We will also address the methodological, neurophilosophical and neurotheological questions concerning the extent to which religious and spiritual experiences can be neurobiologically explained. We will summarise the rapidly expanding knowledge about the neuroscience of meditation and prayer, near-death experiences, ecstatic epilepsy, psychedelic experiences, and changes in spirituality associated with brain lesions. Additionally, we will discuss the validity of suggestions, based on predictive processing theory, that ecstatic states may represent a pathology of the mind and brain in the form of impaired prediction. Finally, we will describe the beneficial and therapeutic effects of spiritual and religious routines and practices and put them in the context of evolutionary medicine. Overall, we will argue that ‘neurospirituality’ research can be fruitful if it avoids both excessive reductionism as well as dualism. Instead, it should be based on limited reductionism, balanced by more integrative, non-localisationist approaches, including dynamical systems, complex systems and network theory.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106319"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights 物质使用障碍的精准医学：整合行为、环境和生物学见解。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106311

Cyprien G.J. Guerrin , Debbie R.M. Tesselaar , Jan Booij , Arnt F.A. Schellekens , Judith R. Homberg

{"title":"Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights","authors":"Cyprien G.J. Guerrin , Debbie R.M. Tesselaar , Jan Booij , Arnt F.A. Schellekens , Judith R. Homberg","doi":"10.1016/j.neubiorev.2025.106311","DOIUrl":"10.1016/j.neubiorev.2025.106311","url":null,"abstract":"<div><div>Substance use disorders (SUD) are chronic, relapsing conditions marked by high variability in treatment response and frequent relapse. This variability arises from complex interactions among behavioral, environmental, and biological factors unique to each individual. Precision medicine, which tailors treatment to patient-specific characteristics, offers a promising avenue to address these challenges. This review explores key factors influencing SUD, including severity, comorbidities, drug use motives, polysubstance use, cognitive impairments, and biological and environmental influences. Advanced neuroimaging, such as MRI and PET, enables patient subtyping by identifying altered brain mechanisms, including reward, relief, and cognitive pathways, and striatal dopamine D<sub>2/3</sub> receptor binding. Pharmacogenetic and epigenetic studies uncover how variations in dopaminergic, serotoninergic, and opioidergic systems shape treatment outcomes. Emerging biomarkers, such as neurofilament light chain, offer non-invasive relapse monitoring. Multifactorial models integrating behavioral and neural markers outperform single-factor approaches in predicting treatment success. Machine learning refines these models, while longitudinal and preclinical studies support individualized care. Despite translational hurdles, precision medicine offers transformative potential for improving SUD treatment outcomes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106311"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural bases of meaningful intransitive gestures: A meta-analysis of lesion and fMRI studies 有意义不及物手势的神经基础：损伤和功能磁共振研究的荟萃分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106316

Josselin Baumard , Alice Laniepce , Léna Guezouli , François Osiurak , Mathieu Lesourd , Angela Bartolo

{"title":"The neural bases of meaningful intransitive gestures: A meta-analysis of lesion and fMRI studies","authors":"Josselin Baumard , Alice Laniepce , Léna Guezouli , François Osiurak , Mathieu Lesourd , Angela Bartolo","doi":"10.1016/j.neubiorev.2025.106316","DOIUrl":"10.1016/j.neubiorev.2025.106316","url":null,"abstract":"<div><div>Meaningful intransitive (MFI) gestures have long been used by clinicians and researchers to assess gesture production and recognition, especially in the context of neuropsychological disorders like apraxia. Their neural bases, however, remain unclear. The goal of this systematic, theory-driven meta-analysis of 6 lesion studies and 21 fMRI studies was to investigate the cerebral networks of MFI gestures. The results suggested that MFI gesture processing depends on a large, left-lateralized, cortico-subcortical, fronto-temporo-insular and cerebellar neural network also involved in social cognition and skills. A bilateral cluster was also found in medial and cingulate brain regions. The left inferior parietal lobe, typically involved in tool use and imitation skills, was part of this network for gesture production – although it did not survive statistical control. These results challenge traditional neurocognitive models and suggest that MFI gestures, although represented widely in the brain, call for specific socio-cognitive processes. The discussion offers a comprehensive framework of the neural bases of MFI gestures, along with methodological considerations and future directions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106316"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ventral midline thalamus: Participation in neurological and neuropsychiatric disorders 腹侧丘脑中线：参与神经和神经精神疾病。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106315

Jean-Christophe Cassel , Elodie Panzer , Isabella Guimaraes-Olmo , Brigitte Cosquer , Anne Pereira de Vasconcelos , Aline Stéphan

{"title":"The ventral midline thalamus: Participation in neurological and neuropsychiatric disorders","authors":"Jean-Christophe Cassel , Elodie Panzer , Isabella Guimaraes-Olmo , Brigitte Cosquer , Anne Pereira de Vasconcelos , Aline Stéphan","doi":"10.1016/j.neubiorev.2025.106315","DOIUrl":"10.1016/j.neubiorev.2025.106315","url":null,"abstract":"<div><div>The ventral midline thalamus comprises the reuniens and rhomboid nuclei (ReRh). These nuclei are bidirectionally connected not only with two key brain structures relevant to cognition – the (medial) prefrontal cortex and the hippocampus – but also with over thirty other brain regions, often reciprocally. Over the past two decades, these nuclei have attracted increasing interest for their roles in various memory functions, including working memory and systems consolidation, as well as in behavioral flexibility, emotions such as fear, and the regulation of plasticity. Unsurprisingly, the Re nucleus, and occasionally its neighbor, the Rh nucleus, have been implicated in several neurological conditions and neuropsychiatric disorders. This review focuses on Alzheimer’s disease and epilepsy before addressing neuropsychiatric alterations such as anxiety, depression, chronic stress, schizophrenia, fetal alcohol syndrome, and fear encoding, generalization and extinction. When available, we first discuss clinical studies in humans, often very briefly, followed by experimental approaches using a wide range of animal models. The involvement of the ReRh nuclei in both memory processing and emotional regulation suggests that their dysregulation may represent a common pathological mechanism underlying the cognitive and affective symptoms shared across these disorders. Therefore, understanding the precise contributions of the ReRh nuclei to these diseases could reveal novel therapeutic targets for intervention.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106315"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0