Neuroscience and Biobehavioral Reviews最新文献

{"title":"Efficacy and safety of transcranial direct current stimulation (tDCS) in patients with obsessive-compulsive disorder (OCD): A systematic review and meta-analysis of randomized controlled trials","authors":"Reza Moshfeghinia ,&nbsp;Amirhossein Najibi ,&nbsp;Fahimeh Golabi ,&nbsp;Mehrnaz Moradi ,&nbsp;Mahdi Malekpour ,&nbsp;Saeed Abdollahifard ,&nbsp;Konstantin Slavin ,&nbsp;Ali Razmkon","doi":"10.1016/j.neubiorev.2025.106171","DOIUrl":"10.1016/j.neubiorev.2025.106171","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial direct current stimulation (tDCS) is gaining traction for treating obsessive-compulsive disorder (OCD), but its effectiveness and safety remain uncertain. A systematic review of randomized controlled trials (RCTs) will assess its clinical benefits for symptom reduction.</div></div><div><h3>Methods</h3><div>Six databases—Scopus, PubMed, Web of Science, Cochrane, PsycINFO, and Cochrane Central—were searched to identify relevant studies. The included studies were RCTs that assessed the effects of tDCS on OCD symptoms, as well as its impact on anxiety and depression, while also evaluating adverse events (AEs). The risk of bias (ROB) was analyzed using the ROB-2 tool. A meta-analysis was performed utilizing Stata-17 software.</div></div><div><h3>Results</h3><div>Immediately following treatment, the analysis revealed that tDCS significantly reduced the Y-BOCS score (SMD = −0.56 [-0.87, −0.26]), anxiety scores (SMD = −1.11 [-1.85, −0.37]), and depression scores (SMD = −1.57 [-2.64, −0.50]), while increasing CGI-S scores (SMD = 0.40 [0.08, 0.72]) in OCD patients compared to the sham group. During the follow-up period (1–2 months post-treatment), tDCS continued to decrease the Y-BOCS score (SMD = −0.69 [-1.22, −0.17]), anxiety scores (SMD = −1.13 [-3.05, −0.78]), and depression scores (SMD = −2.02 [-3.00, −1.04]), but showed no effect on CGI-S scores when compared to the sham group. Additionally, the analysis indicated no significant differences in AEs between active tDCS and the sham group (OR: 1.20 [0.86, 1.68]).</div></div><div><h3>Conclusions</h3><div>This review suggests that tDCS may effectively alleviate OCD symptoms, along with related depression and anxiety, both acute and at follow-up, while causing minimal AEs.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106171"},"PeriodicalIF":7.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parcellation of individual brains: From group level atlas to precise mapping","authors":"Chengyi Li ,&nbsp;Shan Yu ,&nbsp;Yue Cui","doi":"10.1016/j.neubiorev.2025.106172","DOIUrl":"10.1016/j.neubiorev.2025.106172","url":null,"abstract":"<div><div>Individual brains vary greatly in morphology, connectivity, and organization. Group-level brain parcellations, which do not account for individual variations in brain parcels, are increasingly limited in their applicability, especially given the rapid development of precision medicine. Accurate individual-level brain functional mapping is pivotal for comprehending variations in brain functions and behaviors, the early and precise identification of brain abnormalities, and personalized treatments for neuropsychiatric disorders. Recent advances in neuroimaging and machine learning techniques have led to a surge in studies on the parcellation of individual brains. In this paper, we present an overview of recent advances in the methodologies of individual brain parcellation, including optimization- and learning-based methods. We then introduce comprehensive evaluation metrics to validate individual functional regions, and discuss how individual brain mapping advances neuroscience research and clinical medicine. Finally, major challenges and future directions of individual brain parcellation are summarized. In conclusion, we provide a comprehensive overview of individual brain parcellation methods, validations, and applications, highlighting current challenges and the urgent need for integrated platforms that encompass datasets, methods, and validations.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106172"},"PeriodicalIF":7.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ‘reading’ brain: Meta-analytic insight into functional activation during reading in adults","authors":"Sabrina Turker ,&nbsp;Beatrice Fumagalli ,&nbsp;Philipp Kuhnke ,&nbsp;Gesa Hartwigsen","doi":"10.1016/j.neubiorev.2025.106166","DOIUrl":"10.1016/j.neubiorev.2025.106166","url":null,"abstract":"<div><div>Literacy provides the key to social contacts, education, and employment, and significantly influences well-being and mental health. Summarizing 163 studies, the present coordinate-based meta-analysis confirms the importance of classical left-hemispheric language regions and the cerebellum across reading tasks. We found high processing specificity for letter, word, sentence, and text reading exclusively in left-hemispheric areas. Subregions within the left inferior frontal gyrus showed differential engagement for word and pseudoword reading, while subregions within the left temporo-occipital cortex showed differential engagement for words and sentences. The direct comparison of overt and covert reading revealed higher activation likelihood in auditory and motor regions during the first, and more consistent reliance on multiple demand regions during the latter. Last, silent word and pseudoword reading (explicit reading) yielded more consistent activation in left orbito-frontal, cerebellar and temporal cortices when compared to lexical decisions (implicit reading). Lexical decisions, in contrast, showed more consistent bilateral recruitment of inferior frontal and insular regions. The present meta-analysis significantly extends our understanding of the neural architecture underlying reading, corroborates findings from neurostimulation studies and can provide valuable neural insight into reading models.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106166"},"PeriodicalIF":7.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise interventions for health outcomes in children with autism spectrum disorder: An umbrella review of meta-analyses of clinical trials","authors":"Xiuyan Gao ,&nbsp;Guangjun Xu ,&nbsp;Ningning Fu ,&nbsp;Lin Wang ,&nbsp;Qi Ben ,&nbsp;Mengchao Shen ,&nbsp;Xiumei Bu","doi":"10.1016/j.neubiorev.2025.106144","DOIUrl":"10.1016/j.neubiorev.2025.106144","url":null,"abstract":"<div><div>Exercise interventions have gained widespread acceptance due to their cost-effectiveness, ease of implementation, and low incidence of negative effects. However, the overall effects of exercise interventions on the health outcomes of children with autism are not evaluated systematically. To evaluate the effect of exercise interventions on behavioral, motorial, and psychosocial health outcomes in autistic children, as well as to determine the quality of evidence for each outcome. We conducted an umbrella review of meta-analyses investigating the associations between exercise interventions and health outcomes in autistic children from inception to November 27, 2024. Following exercise interventions, maladaptive behavior [standardized mean difference (SMD): −0.73; 95 % confidence interval (95 % CI): −0.71, −0.03] showed a substantial improvement. However, no discernible impact on stereotyped behavior (SMD: 0.09; 95 % CI: −0.30, 0.48) was observed. Sensitivity analysis revealed that all overall effect sizes indicated statistically significant differences, even though the reanalysis of meta-analyses showed no significant effectiveness of exercise interventions on social communication (SMD: −0.09; 95 % CI: −0.61, 0.43), social skill (SMD = −0.22; 95 % CI: −0.99, 0.54), social function (SMD = 2.64; 95 % CI: −0.10, 5.39), and motor skills (SMD: 0.71; 95 % CI: −0.97, 2.39). Exercise interventions are suggested to improve maladaptive behaviors and may help with social communication, social skills, social function, and motor skills. The evidence for the effectiveness of exercise interventions in reducing stereotyped behaviors is weak, but it still merits investigation. We need more carefully planned randomized controlled studies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106144"},"PeriodicalIF":7.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The remapping of peripersonal space after stroke, spinal cord injury and amputation: A PRISMA systematic review","authors":"Riccardo De Pastina ,&nbsp;Salvatore Gaetano Chiarella ,&nbsp;Luca Simione ,&nbsp;Antonino Raffone ,&nbsp;Mariella Pazzaglia","doi":"10.1016/j.neubiorev.2025.106168","DOIUrl":"10.1016/j.neubiorev.2025.106168","url":null,"abstract":"<div><div>Peripersonal space (PPS) is the body-centered area where interactions occur and objects can be reached. Its boundaries are dynamic, modulated by ongoing sensorimotor experiences: limb immobilization shrinks PPS, whereas tool use expands it. However, consistent clinical information on PPS alterations remains limited due to methodological heterogeneity, varying types and severities of sensorimotor disorders, and diverse experimental paradigms. This review explores the causal mechanisms of PPS processing by integrating findings from brain-lesioned patients and individuals with body deafferentation, such as amputees and spinal cord injury (SCI) patients. By comparing the effects of brain lesions and sensorimotor deafferentation, it clarifies how PPS is encoded, maintained, and reorganized following central nervous system damage, bodily changes, and the use of assistive devices. A systematic search of Scopus, Web of Science, and PubMed identified 17 studies: 4 on stroke patients (N = 100), 6 on SCI patients (N = 104), and 7 on amputees (N = 65). Risk of bias was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Despite the limited number of studies and methodological variability, findings consistently show that sensorimotor changes significantly affect PPS. Notably, a contraction of PPS around the affected limb was observed in stroke, SCI patients, and amputees. Assistive devices were able to restore PPS after training, or even immediately in the case of prosthesis use. A shared neurophysiological mechanism across these conditions may underlie PPS as an online construct, continuously updated to reflect the body’s current state and its interaction with the environment.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106168"},"PeriodicalIF":7.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Glucagon-Like Peptide-1 on Amyloid, Tau, and α-Synuclein: Target Engagement and Rationale for the Development in Neurodegenerative Disorders","authors":"Hezekiah C.T. Au ,&nbsp;Pak Ho Lam ,&nbsp;Poh Khuen Lim ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.neubiorev.2025.106159","DOIUrl":"10.1016/j.neubiorev.2025.106159","url":null,"abstract":"<div><h3>Introduction</h3><div>Glucagon-like Peptide-1 (GLP-1) and Glucagon-Like Peptide-1 receptor agonist (GLP-1 RA) administration has been associated with neuroprotective effects in neurodegenerative disorders. We conducted a comprehensive synthesis of known effects of GLP-1 and GLP-1 RAs on the cognitive, cellular, and molecular changes in neurodegenerative diseases.</div></div><div><h3>Methods</h3><div>We examined preclinical and clinical paradigms that investigated changes in neurodegenerative disease pathology following administration of GLP-1 and GLP-1 RAs. Relevant articles were retrieved through OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to September 27th, 2024. Primary studies investigating the aforementioned changes following GLP-1 and GLP-1 RA administration were retrieved for analysis (n = 62).</div></div><div><h3>Results</h3><div>GLP-1 and GLP-1 RAs (i.e. dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, and tirzepatide) improved cognitive and motor function in neurodegenerative diseases in preclinical and clinical paradigms. Additionally, GLP-1 and GLP-1 RAs were associated with modulating changes in neuroinflammation, oxidative stress, and proliferative pathways.</div></div><div><h3>Discussion</h3><div>We observed that GLP-1 and GLP-1 RAs modulate molecular and cellular changes known to govern the phenomenology of neurodegenerative diseases. Future research should examine the interaction between signaling molecules, neuronal subpopulations, and cognitive effects affected by GLP-1 and GLP-1 RA administration.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106159"},"PeriodicalIF":7.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From social effort to social behavior: An integrated neural model for social motivation","authors":"Alisa Kanterman,&nbsp;Simone Shamay-Tsoory","doi":"10.1016/j.neubiorev.2025.106170","DOIUrl":"10.1016/j.neubiorev.2025.106170","url":null,"abstract":"<div><div>As humans rely on social groups for survival, social motivation is central to behavior and well-being. Here we define social motivation as the effort that initiates and directs behavior towards social outcomes, with the goal of satisfying our fundamental need for connection. We propose an integrated framework of social motivation which emphasizes the maintenance of optimal connection levels through effort exertion, regulating social approach and avoidance, which allow interpersonal synchrony. Together, these behaviors serve as basic building blocks of social behavior, and give rise to behaviors critical for collective living such as cooperation and empathy. We describe a neural model according to which social connection levels are monitored by the hypothalamus, while the anterior cingulate cortex and anterior insula respond to detected social deficiency. As adjustment is required, the social effort system – comprised of the thalamus and striatum – is activated. This system directs neural networks that permit interpersonal synchrony or, conversely, desynchronization, aiming to restore and maintain optimal connection by preventing isolation on the one hand, and exaggerated social closeness on the other hand. The proposed framework offers insights into disorders characterized by aberrant social motivation, potentially identifying neural dysfunctions that may inform novel interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106170"},"PeriodicalIF":7.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between accelerated and standard or sham rTMS in the treatment of depression: A systematic review","authors":"Jean-Pascal Lefaucheur ,&nbsp;Carlotta Colzi ,&nbsp;Eric Hollander ,&nbsp;Ilenia Pampaloni ,&nbsp;Michael Van Ameringen ,&nbsp;Chris Baeken ,&nbsp;Paolo Fusar-Poli ,&nbsp;Celso Arango ,&nbsp;Leonardo F. Fontenelle ,&nbsp;Jean-Marie Batail ,&nbsp;André R. Brunoni ,&nbsp;Humberto Nicolini ,&nbsp;Emmanuel Haffen ,&nbsp;Carles Soriano-Mas ,&nbsp;Carolyn I. Rodriguez ,&nbsp;Bernardo Maria Dell’Osso ,&nbsp;Eduard Vieta ,&nbsp;Anne Sauvaget ,&nbsp;David Szekely ,&nbsp;Andreas Mayer-Linderberg ,&nbsp;Stefano Pallanti","doi":"10.1016/j.neubiorev.2025.106140","DOIUrl":"10.1016/j.neubiorev.2025.106140","url":null,"abstract":"<div><div>Major depressive disorder (MDD) represents a major global health challenge, with a significant proportion of patients being resistant to drug treatment (TRD). Repetitive transcranial magnetic stimulation (rTMS) has shown promise in the treatment of MDD/TRD, with a single stimulation session per day for five days per week over several weeks (the \"standard\" protocol). The two main paradigms used are high-frequency rTMS and intermittent theta burst stimulation (iTBS) delivered to the left dorsolateral prefrontal cortex (DLPFC). Accelerated TMS (aTMS) protocols aim to make the treatment more effective, or at least more rapidly effective, by delivering more stimulations in a shorter time, which could also facilitate the implementation of the protocols for a larger number of patients. In this systematic literature review, articles comparing in the same study an aTMS protocol to a standard or sham rTMS protocol were retained for analysis. Thus, 23 articles were retained and the analysis focused on the efficacy of aTMS protocols used for the treatment of depression (MDD/TRD) as well as on the impact of various stimulation parameters, such as stimulation pattern, intersession interval, dosage, and methods of cortical targeting. Although some studies did not report significant differences between aTMS and standard or sham protocols, others suggested potential advantages of aTMS, such as twice-daily HF-rTMS of the left DLPFC or more intensive iTBS protocols with a long interval between two sessions and personalized cortical targeting. Our results highlight the influence of the number of sessions or pulses per session (dosage), the duration of the interval between sessions, and the precision of target localization (using image-guided neuronavigation) on therapeutic efficacy. However, limitations in sample size, few independent studies replicating the same methodology, and variability in the clinical profile of treated patients, given different definitions of treatment resistance or the presence of comorbidities, hamper definitive conclusions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106140"},"PeriodicalIF":7.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome characteristics in individuals across different stages of schizophrenia spectrum disorders: A systematic review and meta-analysis","authors":"Li Kong ,&nbsp;Xingsong Wang ,&nbsp;Guanlin Chen ,&nbsp;Yikang Zhu ,&nbsp;Lina Wang ,&nbsp;Miaomiao Yan ,&nbsp;Jingwen Zeng ,&nbsp;Xiaoqi Zhou ,&nbsp;Simon S.Y. Lui ,&nbsp;Raymond C.K. Chan","doi":"10.1016/j.neubiorev.2025.106167","DOIUrl":"10.1016/j.neubiorev.2025.106167","url":null,"abstract":"<div><div>Schizophrenia (SCZ) is a complex neuropsychiatric disorder with unclear pathogenesis, limiting advances in early diagnosis and targeted interventions. Increasing evidence suggests that the gut microbiome contributed to SCZ pathophysiology, yet comprehensive characterization across illness stages remains lacking. This meta-analysis aimed to characterize gut microbial alterations across the SCZ spectrum disorder, including individuals at ultra-high risk for psychosis, first-episode psychosis (FEP) and chronic SCZ patients. A systematic search of 10 databases identified 91 case-control studies. Gut microbial outcome measures included relative abundance, alpha and beta diversity. Review Manager and R were used to analyze the data. The results showed that patients with SCZ exhibited significantly reduced alpha diversity, particularly in Shannon, Chao1, Observe and Evenness indices, compared to healthy controls. Beta diversity also differed significantly, with 88.5 % of studies reporting distinct microbial profiles across SCZ stages. Quantitative analysis revealed significantly increased relative abundance of Bacteroides and a decrease abundance of Bifidobacterium and Lactobacilli in FEP patients compared to healthy controls. Qualitative analysis further showed increasing abundance in Lactobacillus, Prevotella and Collinsella, but decreasing abundance in Faecalibacterium, Butyricicoccus, and Blautia in SCZ. Bifidobacterium exhibited stage-specific changes, decreasing in first-episode psychosis but increasing in chronic stages, while Bacteroides followed an opposite trajectory. Notably, Lactobacillus demonstrated an early upward tractor in high-risk individuals, persisting to chronic stages. This meta-analysis identified dynamic and consistent alterations in the gut microbial across the SCZ spectrum. These findings implicated the potentials of gut microbes as early indicators for identification and intervention of SCZ.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106167"},"PeriodicalIF":7.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common neural activations of creativity and exploration: A meta-analysis of task-based fMRI studies","authors":"Yingying Liu ,&nbsp;Mengmeng Wang ,&nbsp;Hengyi Rao","doi":"10.1016/j.neubiorev.2025.106158","DOIUrl":"10.1016/j.neubiorev.2025.106158","url":null,"abstract":"<div><div>Creativity is a common, complex, and multifaceted cognitive activity with significant implications for technological progress, social development, and human survival. Understanding the neurocognitive mechanisms underlying creative thought is essential for fostering individual creativity. While previous studies have demonstrated that exploratory behavior positively influences creative performance, few studies investigated the relationship between creativity and exploration at the neural level. To address this gap, we conducted a quantitative meta-analysis comprising 80 creativity experiments (1850 subjects) and 23 exploration experiments (646 subjects) to examine potential shared neural activations between creativity and exploration. Furthermore, we analyzed the neural similarities and differences among three forms of creative thinking—divergent thinking (DT), convergent thinking (CT), and artistic creativity—and their relationship with exploration. The conjunction analysis of creativity and exploration revealed significant activations in the bilateral IFJ and left preSMA. Further conjunction analyses revealed that both CT and artistic creativity exhibited common neural activations with exploration, with CT co-activating the left IFJ and artistic creativity co-activating both the right IFJ and left preSMA, while DT did not. Additionally, the conjunction analyses across the three forms of creativity did not identify shared neural activations. Further functional decoding analyses of the overlapping brain regions associated with CT and exploration, as well as artistic creativity and exploration, revealed correlations with inhibitory control mechanisms. These results enhance our understanding of the role of exploration in the creative thinking process and provide valuable insights for developing strategies to foster innovative thinking.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106158"},"PeriodicalIF":7.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}