Neuroscience and Biobehavioral Reviews最新文献_第8页

Maternal immune activation and its multifaceted effects on learning and memory in rodent offspring: A systematic review 母体免疫激活及其对啮齿动物后代学习和记忆的多方面影响：系统综述

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-04 DOI: 10.1016/j.neubiorev.2024.105844

{"title":"Maternal immune activation and its multifaceted effects on learning and memory in rodent offspring: A systematic review","authors":"","doi":"10.1016/j.neubiorev.2024.105844","DOIUrl":"10.1016/j.neubiorev.2024.105844","url":null,"abstract":"<div><p>This systematic review explored the impact of maternal immune activation (MIA) on learning and memory behavior in offspring, with a particular focus on sexual dimorphism. We analyzed 20 experimental studies involving rodent models (rats and mice) exposed to either lipopolysaccharide (LPS) or POLY I:C during gestation following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our findings reveal that most studies report a detrimental impact of MIA on the learning and memory performance of offspring, highlighting the significant role of prenatal environmental factors in neurodevelopment. Furthermore, this review underscores the complex effects of sex, with males often exhibiting more pronounced cognitive impairment compared to females. Notably, a small subset of studies report enhanced cognitive function following MIA, suggesting complex, context-dependent outcomes of prenatal immune challenges. This review also highlights sex differences caused by the effects of MIA in terms of cytokine responses, alterations in gene expression, and differences in microglial responses as factors that contribute to the cognitive outcomes observed.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003130/pdfft?md5=eaf3d048c0934a4769598278b2c71eb6&pid=1-s2.0-S0149763424003130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes 拓展神经（活性）类固醇的治疗潜力：治疗多巴胺能亢进行为表型的可行策略。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-03 DOI: 10.1016/j.neubiorev.2024.105842

{"title":"Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes","authors":"","doi":"10.1016/j.neubiorev.2024.105842","DOIUrl":"10.1016/j.neubiorev.2024.105842","url":null,"abstract":"<div><p>Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson’s Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in various physiological processes and pathological conditions. Specifically, subclasses of Neuro(active)steroids belonging to the 5<em>α</em> reductase pathway are prominently involved in brain disorders characterized by dopaminergic signaling imbalances. This review highlights the neuromodulatory effects of Neuro(active)steroids on the dopamine system and related aberrant behavioral phenotypes. We critically appraise the role of pregnenolone, progesterone, and allopregnanolone on dopamine signaling. Additionally, we discuss the impact of pharmacological interventions targeting 5<em>α</em> reductase activity in neuropsychiatric conditions characterized by excessive activation of the dopaminergic system, ranging from psychotic (endo)phenotypes and motor complications to decision-making problems and addiction.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003117/pdfft?md5=c48f1b2908ce36b824a85f308fb1bbdd&pid=1-s2.0-S0149763424003117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant inhibitory control as a transdiagnostic dimension of mental disorders – A meta-analysis of the antisaccade task in different psychiatric populations 抑制控制失常是精神障碍的一个跨诊断维度--对不同精神病人群的反施法任务的荟萃分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-03 DOI: 10.1016/j.neubiorev.2024.105840

{"title":"Aberrant inhibitory control as a transdiagnostic dimension of mental disorders – A meta-analysis of the antisaccade task in different psychiatric populations","authors":"","doi":"10.1016/j.neubiorev.2024.105840","DOIUrl":"10.1016/j.neubiorev.2024.105840","url":null,"abstract":"<div><p>This meta-analysis examined inhibitory control performance in the antisaccade task across mental disorders. Following PRISMA guidelines, we analyzed data from <em>k</em> = 146 studies (<em>n</em> = 13,807 participants) on antisaccade performance. Effect sizes were estimated using random-effects models and restricted maximum-likelihood estimation, with robustness tests for study heterogeneity and publication bias. Most disorders displayed elevated error rates, with schizophrenia showing the greatest impairments, followed by autism spectrum disorder, bipolar disorder and attention deficit hyperactivity disorder. Small to medium impairments were also found in eating disorders, major depressive disorder, obsessive-compulsive disorder and substance use disorder. Results were robust against corrections for publication bias and largely unaffected by confounding variables. Prolonged latencies were observed in schizophrenia, attention deficit hyperactivity disorder, bipolar disorder and obsessive compulsive disorder, with smaller and less robust effect sizes. Results indicate inhibitory control deficits in the antisaccade task across mental disorders, especially evident for error rates. While present in most disorders, results imply varying degrees of impairments, ranging from small to large in effect sizes, with largest impairments in schizophrenia.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003099/pdfft?md5=ef8be0071111e257795215f67e6817b7&pid=1-s2.0-S0149763424003099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Default mode network dynamics: An integrated neurocircuitry perspective on social dysfunction in human brain disorders 默认模式网络动力学：从综合神经回路角度看人类大脑疾病中的社交功能障碍。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-02 DOI: 10.1016/j.neubiorev.2024.105839

{"title":"Default mode network dynamics: An integrated neurocircuitry perspective on social dysfunction in human brain disorders","authors":"","doi":"10.1016/j.neubiorev.2024.105839","DOIUrl":"10.1016/j.neubiorev.2024.105839","url":null,"abstract":"<div><p>Our intricate social brain is implicated in a range of brain disorders, where social dysfunction emerges as a common neuropsychiatric feature cutting across diagnostic boundaries. Understanding the neurocircuitry underlying social dysfunction and exploring avenues for its restoration could present a transformative and transdiagnostic approach to overcoming therapeutic challenges in these disorders. The brain's default mode network (DMN) plays a crucial role in social functioning and is implicated in various neuropsychiatric conditions. By thoroughly examining the current understanding of DMN functionality, we propose that the DMN integrates diverse social processes, and disruptions in brain communication at regional and network levels due to disease hinder the seamless integration of these social functionalities. Consequently, this leads to an altered balance between self-referential and attentional processes, alongside a compromised ability to adapt to social contexts and anticipate future social interactions. Looking ahead, we explore how adopting an integrated neurocircuitry perspective on social dysfunction could pave the way for innovative therapeutic approaches to address brain disorders.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003087/pdfft?md5=d64714505cb6584325fe4188c266a856&pid=1-s2.0-S0149763424003087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From neurons to brain networks, pharmacodynamics of stimulant medication for ADHD 从神经元到大脑网络，治疗 adhd 的兴奋剂的药效学。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-02 DOI: 10.1016/j.neubiorev.2024.105841

{"title":"From neurons to brain networks, pharmacodynamics of stimulant medication for ADHD","authors":"","doi":"10.1016/j.neubiorev.2024.105841","DOIUrl":"10.1016/j.neubiorev.2024.105841","url":null,"abstract":"<div><p>Stimulants represent the first line pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD) and are among the most prescribed psychopharmacological treatments. Their mechanism of action at synaptic level has been extensively studied. However, it is less clear how their mechanism of action determines clinically observed benefits. To help bridge this gap, we provide a comprehensive review of stimulant effects, with an emphasis on nuclear medicine and magnetic resonance imaging (MRI) findings. There is evidence that stimulant-induced modulation of dopamine and norepinephrine neurotransmission optimizes engagement of task-related brain networks, increases perceived saliency, and reduces interference from the default mode network. An acute administration of stimulants may reduce brain alterations observed in untreated individuals in fronto-striato-parieto-cerebellar networks during tasks or at rest. Potential effects of prolonged treatment remain controversial. Overall, neuroimaging has fostered understanding on stimulant mechanism of action. However, studies are often limited by small samples, short or no follow-up, and methodological heterogeneity. Future studies should address age-related and longer-term effects, potential differences among stimulants, and predictors of treatment response.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003105/pdfft?md5=ceab6209090b1c1cf95b370aa81b062c&pid=1-s2.0-S0149763424003105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review 啮齿动物药物暴露或自我给药效应的神经影像学研究：系统综述。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-01 DOI: 10.1016/j.neubiorev.2024.105823

{"title":"Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review","authors":"","doi":"10.1016/j.neubiorev.2024.105823","DOIUrl":"10.1016/j.neubiorev.2024.105823","url":null,"abstract":"<div><p>A systematic review of functional neuroimaging studies on drug (self-) administration in rodents is lacking. Here, we summarized effects of acute or chronic drug administration of various classes of drugs on brain function and determined consistency with human literature.</p><p>We performed a systematic literature search and identified 125 studies on <em>in vivo</em> rodent resting-state functional magnetic resonance imaging (n = 84) or positron emission tomography (n = 41) spanning depressants (n = 27), opioids (n = 23), stimulants (n = 72), and cannabis (n = 3).</p><p>Results primarily showed alterations in the striatum, consistent with the human literature. The anterior cingulate cortex and (nonspecific) prefrontal cortex were also frequently implicated. Upregulation was most often found after shorter administration and downregulation after long chronic administration, particularly in the striatum. Importantly, results were consistent across study design, administration models, imaging method, and animal states.</p><p>Results provide evidence of altered resting-state brain function in rodents upon drug administration, implicating the brain’s reward network analogous to human studies. However, alterations were more dynamic than previously known, with dynamic adaptation depending on the length of drug administration.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424002926/pdfft?md5=c4ecff9b02910d0389a150b31381f7bb&pid=1-s2.0-S0149763424002926-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dynamics and psychiatric disorders: The missing link 线粒体动力学与精神疾病：缺失的环节

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-07-30 DOI: 10.1016/j.neubiorev.2024.105837

{"title":"Mitochondrial dynamics and psychiatric disorders: The missing link","authors":"","doi":"10.1016/j.neubiorev.2024.105837","DOIUrl":"10.1016/j.neubiorev.2024.105837","url":null,"abstract":"<div><p>Elucidating the molecular mechanisms of psychopathology is crucial for optimized diagnosis and treatment. Accumulating data have underlined how mitochondrial bioenergetics affect major psychiatric disorders. However, how mitochondrial dynamics, a term addressing mitochondria quality control, including mitochondrial fission, fusion, biogenesis and mitophagy, is implicated in psychopathologies remains elusive. In this review, we summarize the existing literature on mitochondrial dynamics perturbations in psychiatric disorders/neuropsychiatric phenotypes. We include preclinical/clinical literature on mitochondrial dynamics recalibrations in anxiety, depression, post-traumatic stress disorder (PTSD), bipolar disorder and schizophrenia. We discuss alterations in mitochondrial network, morphology and shape, molecular markers of the mitochondrial dynamics machinery and mitochondrial DNA copy number (mtDNAcn) in animal models and human cohorts in brain and peripheral material. By looking for common altered mitochondrial dynamics patterns across diagnoses/phenotypes, we highlight mitophagy and biogenesis as regulators of anxiety and depression pathophysiology, respectively, as well as the fusion mediator dynamin-like 120 kDa protein (Opa1) as a molecular hub contributing to psychopathology. Finally, we comment on limitations and future directions in this novel neuropsychiatry field.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconceptualizing complex posttraumatic stress disorder: A predictive processing framework for mechanisms and intervention 重新认识复杂的创伤后应激障碍：机制和干预的预测处理框架

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-07-30 DOI: 10.1016/j.neubiorev.2024.105836

{"title":"Reconceptualizing complex posttraumatic stress disorder: A predictive processing framework for mechanisms and intervention","authors":"","doi":"10.1016/j.neubiorev.2024.105836","DOIUrl":"10.1016/j.neubiorev.2024.105836","url":null,"abstract":"<div><p>In this article, we introduce a framework for interpreting Complex Posttraumatic Stress Disorder (C-PTSD) through predictive processing, a neuroscience concept explaining the brain’s interpretation and prediction of sensory information. While closely related to PTSD, C-PTSD encompasses additional symptom clusters marked by disturbances in self-organization (DSO), such as negative self-concept, affect dysregulation, and relational difficulties, typically resulting from prolonged traumatic stressors. Our model leverages advances in computational psychiatry and neuroscience, offering a mechanistic explanation for these symptoms by illustrating how prolonged trauma disrupts the brain's predictive processing. Specifically, altered predictive mechanisms contribute to C-PTSD's symptomatology, focusing on DSO: (1) Negative self-concept emerges from maladaptive priors that bias perception towards self-criticism, misaligning expected and actual interoceptive states; (2) Misalignment between predicted and actual interoceptive signals leads to affect dysregulation, with sensitivity to bodily cues; and (3) Relationship challenges arise from skewed social prediction errors, fostering mistrust and withdrawal. This precision-focused approach sheds light on the dynamics underpinning C-PTSD and highlights potential intervention targets aimed at recalibrating the predictive processing system.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003051/pdfft?md5=239ad1f35a51deae0e87214339310d75&pid=1-s2.0-S0149763424003051-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ElectroRetinoGraphy toward an exploration of the therapeutic potential of antidepressants in patients with major depressive disorder: A scoping review of the literature 探索抗抑郁药物对重度抑郁症患者的治疗潜力的电复律法：文献综述

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-07-30 DOI: 10.1016/j.neubiorev.2024.105833

{"title":"ElectroRetinoGraphy toward an exploration of the therapeutic potential of antidepressants in patients with major depressive disorder: A scoping review of the literature","authors":"","doi":"10.1016/j.neubiorev.2024.105833","DOIUrl":"10.1016/j.neubiorev.2024.105833","url":null,"abstract":"<div><p>Major Depressive Disorder (MDD) is characterized by at least one major depressive episode. It requires medical attention typically involving the prescription of antidepressants. Remission in MDD patients is often difficult to achieve because of the limited effectiveness of these drugs. Nowadays, numerous patients undergo various antidepressant treatments, with subjective changes in their personal experiences being regularly monitored. Therefore, it is essential to find clinical and objective tools that offer a more tailored approach to antidepressant selection. The neurochemistry of the retina being similar to the brain, one promising approach would be to use ElectroRetinoGraphy (ERG) measurements on MDD patients requiring antidepressant treatment. Thus, the aim of this scoping review is to highlight effects of different classes of antidepressants on retinal function evaluated by full-field ERG (ffERG), Pattern ERG (PERG) and multifocal ERG (mfERG) waveforms in MDD patients. These ERG measurements could serve as pivotal indicators in defining patient profiles, facilitating a more objective and personalized approach to therapeutic interventions, thereby advancing precision psychiatry.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003026/pdfft?md5=ddf9db7718055397e4e203021c13a5aa&pid=1-s2.0-S0149763424003026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common and separable neural alterations in adult and adolescent depression – Evidence from neuroimaging meta-analyses 成人和青少年抑郁症中常见的和可分离的神经改变--来自神经影像学荟萃分析的证据

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-07-29 DOI: 10.1016/j.neubiorev.2024.105835

{"title":"Common and separable neural alterations in adult and adolescent depression – Evidence from neuroimaging meta-analyses","authors":"","doi":"10.1016/j.neubiorev.2024.105835","DOIUrl":"10.1016/j.neubiorev.2024.105835","url":null,"abstract":"<div><p>Depression is a highly prevalent and debilitating mental disorder that often begins in adolescence. However, it remains unclear whether adults and adolescents with depression exhibit common or distinct brain dysfunctions during reward processing. We aimed to identify common and separable neurofunctional alterations during receipt of rewards and brain structure in adolescents and adults with depression. A coordinate-based meta-analysis was employed using Seed-based d mapping with permutation of subject images (SDM-PSI). Compared with healthy controls, both age groups exhibited common activity decreases in the right striatum (putamen, caudate) and subgenual ACC. Adults with depression showed decreased reactivity in the right putamen and subgenual ACC, while adolescents with depression showed decreased activity in the left mid cingulate, right caudate but increased reactivity in the right postcentral gyrus. This meta-analysis revealed shared (caudate) and separable (putamen and mid cingulate cortex) reward-related alterations in adults and adolescents with depression. The findings suggest age-specific neurofunctional alterations and stress the importance of adolescent-specific interventions that target social functions.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0