Neuroscience and Biobehavioral Reviews最新文献_第7页

Dementia and handedness: Meta-analyses 痴呆和惯用手：荟萃分析

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-19 DOI: 10.1016/j.neubiorev.2025.106345

Annakarina Mundorf , Sarah A. Merklein , Jette Borawski , Sebastian Ocklenburg

{"title":"Dementia and handedness: Meta-analyses","authors":"Annakarina Mundorf , Sarah A. Merklein , Jette Borawski , Sebastian Ocklenburg","doi":"10.1016/j.neubiorev.2025.106345","DOIUrl":"10.1016/j.neubiorev.2025.106345","url":null,"abstract":"<div><div>Hemispheric asymmetries are a core feature of brain organization and may influence neurodegenerative processes. Handedness has been proposed as a behavioral marker of lateralization, but its relevance in dementia remains unclear. To determine whether individuals with dementia, including Alzheimer’s disease, differ from healthy controls in the prevalence of left-, mixed-, and non-right-handedness (left- and mixed-handedness), frequentist and Bayesian meta-analytic approaches were used. First, a systematic literature search following PRISMA guidelines was conducted in PubMed and Google Scholar through March 2025 using the terms: “((dementia) OR (Alzheimer's disease)) AND (handedness).” Inclusion criteria required studies to (1) report handedness for both dementia and control groups, (2) not match participants for handedness, and (3) provide sufficient statistical data. Eighteen studies (N = 13,282 dementia patients, N = 18,540 controls) met the criteria. Frequentist meta-analyses showed that individuals with dementia were significantly less likely to be non-right-handed (OR = 0.90, 95 % CI: 0.83–0.97, <em>p</em> = 0.01) and mixed-handed (OR = 0.71, 95 % CI: 0.59–0.85, <em>p</em> = 0.01) compared to controls. However, sensitivity analyses excluding the largest study rendered these associations non-significant, indicating limited robustness. Bayesian meta-analyses supported the null hypothesis with moderate-to-strong evidence across all handedness categories (BF₁₀ = 0.06–1.06). Exploratory Bayesian meta-regressions tested dementia subtype as a moderator and revealed no significant effects. In conclusion, while handedness differences in dementia appear small and sensitive to study design, emerging patterns, particularly in mixed-handedness, may reflect subtle disruptions in hemispheric specialization. Further research may clarify whether such traits provide early behavioral signals of neurodegenerative changes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106345"},"PeriodicalIF":7.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonin-dopamine interactions in psychostimulant-induced gene regulation: SSRI antidepressants potentiate gene regulation by methylphenidate (Ritalin) in the striatum and enhance behavioral profile indicative of addiction liability in rodents 5 -羟色胺-多巴胺在精神兴奋剂诱导的基因调控中的相互作用：SSRI抗抑郁药增强纹状体中哌醋甲酯（利他林）的基因调控，并增强啮齿动物成瘾倾向的行为特征

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-18 DOI: 10.1016/j.neubiorev.2025.106344

Heinz Steiner , Michael Hrabak , Carlos A. Bolaños-Guzmán

{"title":"Serotonin-dopamine interactions in psychostimulant-induced gene regulation: SSRI antidepressants potentiate gene regulation by methylphenidate (Ritalin) in the striatum and enhance behavioral profile indicative of addiction liability in rodents","authors":"Heinz Steiner , Michael Hrabak , Carlos A. Bolaños-Guzmán","doi":"10.1016/j.neubiorev.2025.106344","DOIUrl":"10.1016/j.neubiorev.2025.106344","url":null,"abstract":"<div><div>Selective serotonin reuptake inhibitor (SSRI) antidepressants are used in combination with the medical psychostimulant methylphenidate (Ritalin), a dopamine reuptake inhibitor, in a variety of treatments in children and adults. Unintended co-exposure to these medications also occurs in patients on SSRIs who abuse methylphenidate as a “cognitive enhancer” or recreational drug. This review summarizes a series of studies on the neurobehavioral effects of such drug combinations, administered either orally (mimicking clinical doses) or intraperitoneally (abuse doses), in adolescent rats. Prototypical SSRIs such as fluoxetine (Prozac) given together with methylphenidate produce various behavioral changes, including facilitated acquisition of cocaine self-administration and increased reinstatement of cocaine seeking (model for relapse). Consistent with these behavioral effects, prototypical (but not novel atypical) SSRIs potentiate abuse/addiction-associated gene regulation by methylphenidate in dopamine target areas such as the striatum. Studies investigating the mechanisms underlying these effects revealed that 5-HT1A and 5-HT1B serotonin receptors inhibit and facilitate, respectively, such gene regulation. These findings indicate that combining methylphenidate with prototypical SSRIs may increase the abuse/addiction liability for psychostimulants, and that 5-HT1A and 5-HT1B receptors may serve as pharmacological targets to alleviate this risk.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106344"},"PeriodicalIF":7.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DataMaze: An open source methods and data repository for Morris water maze experiments DataMaze: Morris水迷宫实验的开源方法和数据存储库。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-16 DOI: 10.1016/j.neubiorev.2025.106341

Fuat Balcı , Turaç Aydoğan , Derin Kılıç , Dilay Tetik , İlke Kavuşturan , Feyzanur Polat Kamış , Rana Turmuş , Anisha Sharma , Melak Yossief

{"title":"DataMaze: An open source methods and data repository for Morris water maze experiments","authors":"Fuat Balcı , Turaç Aydoğan , Derin Kılıç , Dilay Tetik , İlke Kavuşturan , Feyzanur Polat Kamış , Rana Turmuş , Anisha Sharma , Melak Yossief","doi":"10.1016/j.neubiorev.2025.106341","DOIUrl":"10.1016/j.neubiorev.2025.106341","url":null,"abstract":"<div><div>A core limitation of behavioural neuroscience is the use of a given assay with very different apparatus specifications (e.g., size) and task parameters (e.g., retention intervals). Such procedural variability largely contributes to the outcome discrepancy across various studies and labs, thereby hindering research progress and the replicability of the outcomes (Crabbe et al., 1999). There is an immediate need for informative and inclusive quantitative benchmarks to design experiments, consider and analyze available data, and interpret the results accordingly, thereby reinforcing the FAIR principles. We took the first step in this direction by establishing a comprehensive database, starting with the Morris water maze (<em>DataMaze</em>). <em>DataMaze</em> contains and consolidates specifications and task parameters from thousands of papers (∼5000) and includes data along with related experimental manipulations. To reinforce this effort, we introduce easy-to-calculate indices that will help compare different studies in terms of parameters and outcomes, both prospectively and retrospectively. We also showcase the use of <em>DataMaze</em> for secondary data analysis. The ultimate aim of <em>DataMaze</em> is to transform research practices and reporting standards in behavioural neuroscience, such that researchers quantitatively utilize virtually all published information in evaluating their experiments, analyzing data, and interpreting results. <em>DataMaze</em> will remain a live and accessible platform that will grow retrospectively by incorporating information from additional studies and prospectively by accepting new and richer entries (e.g., individual subject-level data) from researchers.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106341"},"PeriodicalIF":7.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant use in dementia: Assessing effective strategies for a vulnerable population 抗抑郁药在痴呆中的使用：评估弱势群体的有效策略

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-16 DOI: 10.1016/j.neubiorev.2025.106340

Mariagiovanna Cozza , Filippo Luca Fimognari , Alberto Castagna , Virginia Boccardi

{"title":"Antidepressant use in dementia: Assessing effective strategies for a vulnerable population","authors":"Mariagiovanna Cozza , Filippo Luca Fimognari , Alberto Castagna , Virginia Boccardi","doi":"10.1016/j.neubiorev.2025.106340","DOIUrl":"10.1016/j.neubiorev.2025.106340","url":null,"abstract":"<div><div>Depression is closely associated with dementia and may serve as a risk factor, an early symptom, or a prodromal feature, particularly in Alzheimer’s disease, the most common form of dementia. It can also emerge during disease progression, not only in Alzheimer's but in other dementias such as vascular dementia, Lewy body dementia, and frontotemporal dementia. Recognizing the timing and context of depressive symptoms is crucial for accurate diagnosis and management. While non-pharmacological interventions and psychosocial approaches are generally recommended as the first line of treatment, clinical practice often sees widespread use of antidepressants in this vulnerable population. However, such usage is not always supported by robust evidence, particularly given the heightened risk of side effects in older adults with cognitive decline. This narrative review seeks to critically examine the role of antidepressants in managing depression among patients with dementia. Rather than dismissing their use outright, we aim to provide a novel perspective on their application, emphasizing the importance of a thorough multidimensional geriatric assessment. The attempt is to help the clinicians in making more individualized, evidence-based decisions that balance the potential benefits and risks, ensuring that treatment is tailored to the unique needs of each patient.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106340"},"PeriodicalIF":7.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic mapping and bibliometric analysis of meta-analyses on animal cognition 动物认知meta分析的系统制图和文献计量学分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-16 DOI: 10.1016/j.neubiorev.2025.106342

Ayumi Mizuno , Malgorzata Lagisz , Pietro Pollo , Lauren Guillette , Masayo Soma , Shinichi Nakagawa

{"title":"Systematic mapping and bibliometric analysis of meta-analyses on animal cognition","authors":"Ayumi Mizuno , Malgorzata Lagisz , Pietro Pollo , Lauren Guillette , Masayo Soma , Shinichi Nakagawa","doi":"10.1016/j.neubiorev.2025.106342","DOIUrl":"10.1016/j.neubiorev.2025.106342","url":null,"abstract":"<div><div>Meta-analyses play an important role in empirically synthesising research and guiding future directions. The field of animal cognition is rapidly expanding, with both empirical and review papers increasing at a faster rate than those in the life sciences overall. However, the use of meta-analyses, their methodological rigour, and the geographic distribution of research activity remain unclear. We systematically reviewed 49 meta-analytical studies encompassing 1824 primary studies on animal cognition. Half of the meta-analytical studies focused on the evolution and diversity of non-human animal cognition, while the other half used animals as models to understand human cognition. Most studies addressed factors affecting cognitive abilities, focusing on mammals and birds. Although many studies aimed to examine evolutionary or diversity-related questions, few analysed cognitive variation across species or tested evolutionary hypotheses, and even fewer incorporated phylogenetic relationships. While some studies investigated sex differences, many reported that they could not due to unbalanced sex ratios in the primary studies, notably a predominance of males. Both primary and meta-analytical studies often lacked adequate methodological reporting and rarely shared raw data or analysis scripts. Our bibliometric analysis showed that research is geographically concentrated, with authorship and collaboration mostly in high-income countries. To address current gaps, we recommend greater adherence to open science practices, improved regional inclusivity, and broader taxonomic and individual-level coverage. Finally, we highlight the complementary roles of meta-analyses and Big Team Science in advancing the field by improving its transparency, inclusivity, and reliability.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106342"},"PeriodicalIF":7.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perception of biological motion and actions in Autism: A systematic review 自闭症患者对生物运动和行为的感知：一项系统综述。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-16 DOI: 10.1016/j.neubiorev.2025.106343

Ying Bai, Ellen Poliakoff, Emma Gowen

{"title":"Perception of biological motion and actions in Autism: A systematic review","authors":"Ying Bai, Ellen Poliakoff, Emma Gowen","doi":"10.1016/j.neubiorev.2025.106343","DOIUrl":"10.1016/j.neubiorev.2025.106343","url":null,"abstract":"<div><div>Detecting and recognising the Biological Motion (BM) of other people provides essential information to understand others’ actions and intentions, thus facilitating social interactions. Difficulties with social interaction are a hallmark of autism and may stem from altered perceptual recognition or interpretation of others’ actions. This systematic review investigates whether BM perception in autistic individuals is influenced by the different categories of BM processing and the methodological differences between different BM paradigms. It also explores potential overlap between performance in non-biological motion tasks and BM perception. A total of 51 empirical studies compared BM task performance between 1066 autistic individuals and 1086 non-autistic individuals. Autistic individuals demonstrated poorer performance in BM discrimination tasks that involved greater social cognition. There were no consistent patterns regarding methodological differences across the tasks, such as stimulus types, motion varieties, or level of instructions. When investigated, poorer performance in BM tasks was often mirrored in non-biological motion tasks, suggesting potential overlap in underlying processing mechanisms. Future research should explore a broader range of ages, directly compare performances across tasks, and level of instructions to advance understanding of perceptual processing in autism.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106343"},"PeriodicalIF":7.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive, psychological, and pharmacological correlates of susceptibility to (mis)information: Why we believe and how we resist 对（错误）信息的易感性的认知、心理和药理学相关：我们为什么相信以及我们如何抵制。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-14 DOI: 10.1016/j.neubiorev.2025.106339

Rafal Rygula, Michal Piksa, Agata Cieslik-Starkiewicz

{"title":"Cognitive, psychological, and pharmacological correlates of susceptibility to (mis)information: Why we believe and how we resist","authors":"Rafal Rygula, Michal Piksa, Agata Cieslik-Starkiewicz","doi":"10.1016/j.neubiorev.2025.106339","DOIUrl":"10.1016/j.neubiorev.2025.106339","url":null,"abstract":"<div><div>Misinformation is not a new challenge, but in the digital age, it spreads faster and reaches further than ever before, engaging a complex interplay of cognitive, psychological, and neurobiological mechanisms. This review explores how cognitive factors, personality traits, and environmental influences shape the way people engage with information. It is a narrative review that synthesizes the authors’ previously published empirical work, extended and contextualized in light of relevant findings from the broader literature. Consequently, we present an emerging four-phenotype model of misinformation susceptibility (Consumers, Doubters, Knowers, Duffers), highlighting distinct cognitive, psychological and behavioral profiles. Beyond cognition and psychology, we describe the neurobiological underpinnings of misinformation engagement, including recent findings that serotonergic modulation via selective serotonin reuptake inhibitors (SSRIs) can influence digital behavior without impairing truth discernment. We also evaluate strategies designed to counter misinformation, from cognitive debiasing techniques to interventions that reshape online environments. Finally, we propose future research directions, integrating psychiatry, neuroscience, and behavioral sciences to refine misinformation resistance strategies and explore its potential classification as a psychiatric phenomenon.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106339"},"PeriodicalIF":7.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of risk for adolescent self-harm and suicide: a systematic review and diagram of shared and unique factors in non-clinical samples 青少年自残和自杀风险的决定因素：非临床样本中共同和独特因素的系统回顾和图表。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-13 DOI: 10.1016/j.neubiorev.2025.106323

Bruno Santos , Bibiana Pedra Cruz Bettin , Rosa Maria Martins de Almeida

{"title":"Determinants of risk for adolescent self-harm and suicide: a systematic review and diagram of shared and unique factors in non-clinical samples","authors":"Bruno Santos , Bibiana Pedra Cruz Bettin , Rosa Maria Martins de Almeida","doi":"10.1016/j.neubiorev.2025.106323","DOIUrl":"10.1016/j.neubiorev.2025.106323","url":null,"abstract":"<div><div>Suicide ranks as the second leading cause of death among individuals aged 10–19. Estimates suggest that one-quarter of adolescents have self-harmed at least once, with 1 in 25 of them dying by suicide within 10 years of their initial self-harm presentation. Despite these alarming statistics, most risk assessment tools are designed for adults in clinical settings; a gap in the understanding of shared and unique risk factors for self-injurious behaviours (SIBs) in community adolescents. To address this, we systematically reviewed observational studies examining risk factors for self-harming and suicidal behaviours in non-clinical adolescents. Our protocol adhered to PRISMA guidelines and was registered in PROSPERO (CRD42023463134), with the research question structured using the PICOS framework. We systematically searched EMBASE, Scopus, PubMed, PsycINFO, and Web of Science, supplemented by snowball sampling, and evaluated quality with the Newcastle-Ottawa Scale. Two reviewers independently screened and extracted data, with a senior researcher resolving conflicts. Data were analysed through narrative synthesis. From 1651 articles identified, 8 were included, with sample sizes ranging from 70 to 73,648. Thirty-seven risk factors were identified and visually conveyed through a Sankey diagram. Key factors include female sex, history of SIBs, and vulnerabilities across psychological, neural, familial and social domains. Although many of the studies were cross-sectional and lacked robust ethnic representation, our findings reinforce previous literature linking adolescent SIB to specific individual and contextual factors, contributing a systematic overview that underscores non-clinical adolescent risk and the need for both early identification and tailored prevention and treatment strategies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106323"},"PeriodicalIF":7.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the sufficient conditions for consciousness 意识的充分条件述评

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-13 DOI: 10.1016/j.neubiorev.2025.106333

Peter Coppola

{"title":"A review of the sufficient conditions for consciousness","authors":"Peter Coppola","doi":"10.1016/j.neubiorev.2025.106333","DOIUrl":"10.1016/j.neubiorev.2025.106333","url":null,"abstract":"<div><div>The neuroscience of consciousness has set out to find the sufficient conditions for subjective experience. Theoretical and empirical endeavours have placed a particular focus on the cortex and subcortex, whilst discounting the cerebellum. However, when looking at neuroimaging research, it becomes clear there is substantial evidence that cerebellar, cortical, and subcortical functions are correlated with consciousness. Neurostimulation evidence suggests that alterations in both the cortex and the cerebellum may provoke alterations in experience, however experimental stimulation of the subcortex may abolish, as well as induce, behavioural evidence of experience. Similarly, neuropsychological evidence shows that abnormalities in the cortex, subcortex and cerebellum may provoke changes in experience; but only damage to the oldest regions seems to completely obliterate experience. Finally, I review congenital and experimental decorticate cases and find that behavioural evidence of experience is compatible with the absence of the cortex. The evidence, taken together, indicates that the subcortex is sufficient for behaviours that suggest basic experiences. Based on the findings of this review, I emphasise both the importance of the individual’s developmental trajectory and the interdependencies between different neural systems (e.g., cortex, subcortex and cerebellum) in neurologically typical individuals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106333"},"PeriodicalIF":7.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of MDMA administration on oxytocin concentration levels: systematic review and a multilevel meta-analysis in humans MDMA给药对催产素浓度水平的影响：系统评价和人类多水平荟萃分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-12 DOI: 10.1016/j.neubiorev.2025.106324

Anna Vaslavski , Anna Harwood Gross , Salomon Israel , Leehe Peled-Avron

{"title":"The effect of MDMA administration on oxytocin concentration levels: systematic review and a multilevel meta-analysis in humans","authors":"Anna Vaslavski , Anna Harwood Gross , Salomon Israel , Leehe Peled-Avron","doi":"10.1016/j.neubiorev.2025.106324","DOIUrl":"10.1016/j.neubiorev.2025.106324","url":null,"abstract":"<div><div>3,4-Methylenedioxmethamphetamine (MDMA) has been shown to enhance social cognition, partly through its effects on oxytocin, a neuropeptide involved in social cognition. Despite growing evidence linking MDMA to increased oxytocin levels, no study has systematically examined this relationship across different doses, times, and participant characteristics. This systematic review and meta-analysis evaluates the effects of MDMA administration on peripheral oxytocin levels in humans. A systematic search identified ten studies, comprising 39 effect size estimates. Multilevel meta-analyses were conducted using Hedge’s g as the primary outcome, with dose, time of measurement, and sex as moderators. Results revealed that oxytocin levels increased over time, peaking between 150 and 200 min, before declining. The dose did not significantly predict oxytocin changes, and a trend suggested that samples with a higher proportion of female participants exhibited smaller increases in oxytocin levels. These findings suggest that MDMA transiently elevates oxytocin levels in a time-dependent manner, potentially contributing to its prosocial effects. Importantly, these findings may guide oxytocin-informed timing of MDMA-assisted psychotherapy sessions. Standardization of methods and larger sample sizes are needed to clarify these effects and optimize the therapeutic benefits of MDMA.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106324"},"PeriodicalIF":7.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0