Neuroscience and Biobehavioral Reviews最新文献

{"title":"Inferring when to move","authors":"Thomas Parr ,&nbsp;Ashwini Oswal ,&nbsp;Sanjay G. Manohar","doi":"10.1016/j.neubiorev.2024.105984","DOIUrl":"10.1016/j.neubiorev.2024.105984","url":null,"abstract":"<div><div>Most of our movement consists of sequences of discrete actions at regular intervals—including speech, walking, playing music, or even chewing. Despite this, few models of the motor system address how the brain determines the interval at which to trigger actions. This paper offers a theoretical analysis of the problem of timing movements. We consider a scenario in which we must align an alternating movement with a regular external (auditory) stimulus. We assume that our brains employ generative world models that include internal clocks of various speeds. These allow us to associate a temporally regular sensory input with an internal clock, and actions with parts of that clock cycle. We treat this as process of inferring which clock best explains sensory input. This offers a way in which temporally discrete choices might emerge from a continuous process. This is not straightforward, particularly if each of those choices unfolds during a time that has a (possibly unknown) duration. We develop a route for translation to neurology, in the context of Parkinson’s disease—a disorder that characteristically slows down movements. The effects are often elicited in clinic by alternating movements. We find that it is possible to reproduce behavioural and electrophysiological features associated with parkinsonism by disrupting specific parameters—that determine the priors for inferences made by the brain. We observe three core features of Parkinson’s disease: amplitude decrement, festination, and breakdown of repetitive movements. Our simulations provide a mechanistic interpretation of how pathology and therapeutics might influence behaviour and neural activity.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105984"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highest correlations between emotion regulation strategies and mood symptoms in bipolar disorder: A systematic review and Bayesian network meta-analysis","authors":"Vincenzo Oliva ,&nbsp;Michele De Prisco ,&nbsp;Giovanna Fico ,&nbsp;Chiara Possidente ,&nbsp;Marta Bort ,&nbsp;Lydia Fortea ,&nbsp;Laura Montejo ,&nbsp;Gerard Anmella ,&nbsp;Diego Hidalgo-Mazzei ,&nbsp;Andrea Murru ,&nbsp;Michele Fornaro ,&nbsp;Eduard Vieta ,&nbsp;Joaquim Radua","doi":"10.1016/j.neubiorev.2024.105967","DOIUrl":"10.1016/j.neubiorev.2024.105967","url":null,"abstract":"<div><div>Bipolar disorder (BD) is associated with alterations in emotion regulation (ER) strategies, with both depressive and (hypo)manic symptoms correlated with utilization of maladaptive instead of adaptive strategies. However, which ER strategies are the most affected during the most severe mood symptoms remains unclear despite the potentially relevant treatment implications. To this end, we conducted a systematic review and Bayesian network meta-analysis (NMA) of studies documenting correlations between ER and depressive and (hypo)manic symptoms of BD, from inception until November 9th, 2023. We included 15 studies in the review, 14 of which provided data to conduct a Bayesian NMA. Rumination emerged as the ER strategy most strongly associated with both depressive (ES=0.43, 95 %CrI=0.27,0.59) and (hypo)manic symptoms (ES=0.26, 95 %CrI=0.05,0.46) of BD. Other ER strategies showed associations primarily with depressive symptoms. There was no significant heterogeneity or network inconsistency. These findings emphasize the importance of rumination in BD and suggest that altered ER strategies are more evident in depressive symptoms rather than (hypo)manic ones. While promising for targeted interventions, these results are based on cross-sectional data, limiting causal interpretation. Future longitudinal studies are necessary to clarify the temporal dynamics of the relationship between affective symptoms and ER in BD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105967"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional implications of age-related atrophy of the corpus callosum","authors":"Jean-François Delvenne,&nbsp;Ella Malloy","doi":"10.1016/j.neubiorev.2024.105982","DOIUrl":"10.1016/j.neubiorev.2024.105982","url":null,"abstract":"<div><div>The corpus callosum plays a critical role in inter-hemispheric communication by coordinating the transfer of sensory, motor, cognitive, and emotional information between the two hemispheres. However, as part of the normal aging process, the corpus callosum undergoes significant structural changes, including reductions in both its size and microstructural integrity. These age-related alterations can profoundly impact the brain's ability to coordinate functions across hemispheres, leading to a decline in various aspects of sensory processing, motor coordination, cognitive functioning, and emotional regulation. This review aims to synthesize current research on age-related changes in the corpus callosum, examining the regional differences in atrophy, its underlying causes, and its functional implications. By exploring these aspects, we seek to emphasize the clinical significance of corpus callosum degeneration and its impact on the quality of life in older adults, as well as the potential for early detection and targeted interventions to preserve brain health during aging. Finally, the review calls for further research into the mechanisms underlying corpus callosum atrophy and its broader implications for aging.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105982"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered pain perception and nociceptive thresholds in major depression and anxiety disorders: A meta-analysis","authors":"Simona Scaini ,&nbsp;Simon Davies ,&nbsp;Stefano De Francesco ,&nbsp;Alessio Pelucchi ,&nbsp;Sofia Rubino ,&nbsp;Marco Battaglia","doi":"10.1016/j.neubiorev.2025.106014","DOIUrl":"10.1016/j.neubiorev.2025.106014","url":null,"abstract":"<div><div>Psychiatric conditions can affect the experience of pain. Several reports indicate that Major Depressive Disorder (MDD) is associated with an increased pain threshold, while Anxiety Disorders (ADs) may amplify the perception of pain. However, available data on the nociceptive threshold in these psychiatric conditions are controversial. This meta-analysis examines: 1) the nociceptive threshold among people diagnosed with MDD or ADs compared to healthy controls, and 2) the available evidence that pharmacological treatments affect these relationships. Electronic searches were conducted in PubMed and PsycINFO between June 2022 and December 2024. A total of 25 studies were included. \"Pain threshold\" measurement was considered as a direct comparison between subjects affected by MDD or ADs (both medicated and unmedicated) and healthy control subjects. For each study, the effect size (ES) was calculated, with a positive ES indicating a lower pain threshold. The heterogeneity of the specific set of effect sizes and the effects of selected moderators were tested using the I² index and the Q statistic. Results indicated that patients with Major Depressive Disorder (MDD) had a higher pain threshold (ES: −0.60), while those with Anxiety Disorders (ADs) had a lower pain threshold (ES: −0.34) compared to healthy controls. These findings were confirmed when analyses were limited to studies of unmedicated patients. Exploratory analyses restricted to studies containing medicated MDD patients were inconclusive, and for medicated ADs patients, analyses were not possible due to insufficient data. These meta-analytic data support higher pain threshold associated with MDD, and lower pain threshold associated with ADs.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106014"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological mechanisms of nicotine's effects on feeding and body weight","authors":"Ying Li ,&nbsp;Jian Mao ,&nbsp;Guobi Chai ,&nbsp;Ruimao Zheng ,&nbsp;Xingyu Liu ,&nbsp;Jianping Xie","doi":"10.1016/j.neubiorev.2025.106021","DOIUrl":"10.1016/j.neubiorev.2025.106021","url":null,"abstract":"<div><div>Nicotine, a neuroactive substance in tobacco products, has been widely studied for its effects on feeding and body weight, mostly focusing on the involvement of nervous system, metabolism, hormones, and gut microbiota. To elucidate the action mechanism of nicotine on feeding and body weight, especially the underlying neurobiological mechanisms, we reviewed the studies on nicotine’s effects on feeding and body weight by the regulation of various nerve systems, energy expenditure, peripheral hormones, gut microbiota, etc. The role of neuronal signaling molecules such as AMP-activated protein kinase (AMPK) and kappa opioid receptor (κOR) were specialized in the nicotine-regulating energy expenditure. The energy homeostasis-related neurons, pro-opiomelanocortin (POMC), agouti-related peptide (AgRP), prolactin-releasing hormone (Prlh), etc, were discussed about the responsibility for nicotine’s effects on feeding. Nicotine’s actions on hypothalamus and its related neural circuits were described in view of peripheral nervous system, reward system, adipose browning, hormone secretion, and gut-brain axis. Elucidation of neurobiological mechanism of nicotine’s actions on feeding and body weight will be of immense value to the therapeutic strategies of smoking, and advance the medicine research for the therapy of obesity.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106021"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive coding in neuropsychiatric disorders: A systematic transdiagnostic review","authors":"Brendon Qela ,&nbsp;Stefano Damiani ,&nbsp;Samanta De Santis ,&nbsp;Federica Groppi ,&nbsp;Anna Pichiecchio ,&nbsp;Carlo Asteggiano ,&nbsp;Natascia Brondino ,&nbsp;Alessio Maria Monteleone ,&nbsp;Luigi Grassi ,&nbsp;MNESYS - Mood and Psychosis Sub-Project (Spoke 5) ,&nbsp;Pierluigi Politi ,&nbsp;Paolo Fusar-Poli ,&nbsp;Laura Fusar-Poli","doi":"10.1016/j.neubiorev.2025.106020","DOIUrl":"10.1016/j.neubiorev.2025.106020","url":null,"abstract":"<div><div>The predictive coding framework postulates that the human brain continuously generates predictions about the environment, maximizing successes and minimizing failures based on prior experiences and beliefs. This PRISMA-compliant systematic review aims to comprehensively and transdiagnostically examine the differences in predictive coding between individuals with neuropsychiatric disorders and healthy controls. We included 72 articles including case-control studies investigating predictive coding as the primary outcome and reporting behavioral, neuroimaging, or electrophysiological findings. Thirty-three studies investigated predictive coding in the schizophrenia spectrum, 33 in neurodevelopmental disorders, 5 in mood disorders, 4 in neurocognitive disorders, 1 in post-traumatic stress disorder, and 1 in substance use disorders. Oddball and oddball-like paradigms were most frequently used to quantify predictive coding performance. Evidence showed heterogeneous impairments in the predictive coding abilities of the brain across neuropsychiatric disorders, particularly in schizophrenia and autism. Patients within the schizophrenia spectrum showed a consistent pattern of impaired non-social predictive coding. Conversely, predictive coding deficits were more selective for social cues in the autism spectrum. Predictive coding impairments were correlated with clinical symptom severity. These findings underscore the potential utility of predictive coding as a framework for understanding cognitive dysfunctions in the neuropsychiatric population, even though more evidence is needed on underexplored conditions, also considering potential confounders such as medication use and sex/gender. The potential role of predictive coding as a determinant of treatment response may also be considered to tailor personalized interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106020"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning to fear novel stimuli by observing others in the social affordance framework","authors":"M. Lanzilotto ,&nbsp;O. Dal Monte ,&nbsp;M. Diano ,&nbsp;M. Panormita ,&nbsp;S. Battaglia ,&nbsp;A. Celeghin ,&nbsp;L. Bonini ,&nbsp;M. Tamietto","doi":"10.1016/j.neubiorev.2025.106006","DOIUrl":"10.1016/j.neubiorev.2025.106006","url":null,"abstract":"<div><div>Fear responses to novel stimuli can be learned directly, through personal experiences (Fear Conditioning, FC), or indirectly, by observing conspecific reactions to a stimulus (Social Fear Learning, SFL). Although substantial knowledge exists about FC and SFL in humans and other species, they are typically conceived as mechanisms that engage separate neural networks and operate at different levels of complexity. Here, we propose a broader framework that links these two fear learning modes by supporting the view that social signals may act as unconditioned stimuli during SFL. In this context, we highlight the potential role of subcortical structures of ancient evolutionary origin in encoding social signals and argue that they play a pivotal function in transforming observed emotional expressions into adaptive behavioural responses. This perspective extends the <em>social affordance hypothesis</em> to subcortical circuits underlying vicarious learning in social contexts. Recognising the interplay between these two modes of fear learning paves the way for new empirical studies focusing on interspecies comparisons and broadens the boundaries of our knowledge of fear acquisition.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106006"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How childhood adversity affects components of decision making","authors":"Karen E. Smith ,&nbsp;Yuyan (Lillian) Xu ,&nbsp;Seth D. Pollak","doi":"10.1016/j.neubiorev.2025.106027","DOIUrl":"10.1016/j.neubiorev.2025.106027","url":null,"abstract":"<div><div>Extreme and chronic adverse experiences in childhood are linked to disruptions in a wide range of behavioral processes, including self-regulation, increased risk taking, and impulsivity. One proposed mechanism for these effects is alterations in how children learn and use information about rewards and risk in their environment. This type of decision making is a complex and multifaceted process consisting of distinct subcomponents, each of which may have varying effects on behavior. Here, we conducted a systematic review of the literature examining how reward and risk related decision making is influenced by childhood adversity. We aimed to identify whether childhood adversity is associated with alterations in how children learn about value information and how they subsequently use that information to inform decisions. Results suggest adverse experiences in childhood primarily impacts how individuals prioritize avoidance of risk and leads to devaluation of rewards.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106027"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulse control in Parkinson’s disease: Distinct effects between action and choice","authors":"Aliya C.M. Warden ,&nbsp;Craig McAllister ,&nbsp;Marit F.L. Ruitenberg ,&nbsp;Hayley J. MacDonald","doi":"10.1016/j.neubiorev.2025.106026","DOIUrl":"10.1016/j.neubiorev.2025.106026","url":null,"abstract":"<div><div>Aside from typical motor symptoms, impulse control issues related to engaging in actions or decision-making can manifest in Parkinson’s disease (PD). The lack of direct comparisons between impulsive action and impulsive choice domains hinders a comprehensive understanding of impaired impulse control in this population. Therefore, the current review integrates findings across behavioural measures of impulsive action and choice in PD samples, both on and off dopaminergic medication. The qualitative review of studies revealed a distinction between the two impulsivity domains in the context of PD. While impulsive action impairments present in early, non-medicated PD and persist throughout the disease, impulsive choice deficits may only emerge after time on medication. Research on impulsive choice, especially in non-medicated PD, is limited, and the impact of medication status and disease progression on both domains remains inconclusive. We recommend that future studies integrate impulsive action and choice task types within the same sample and employ longitudinal designs to monitor how disease progression and corresponding medication changes affect impulse control over time.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106026"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The self in depression and anxiety as a transdiagnostic and differential-diagnostic neural marker: A systematic review","authors":"Sami George Sabbah ,&nbsp;Georg Northoff","doi":"10.1016/j.neubiorev.2025.106034","DOIUrl":"10.1016/j.neubiorev.2025.106034","url":null,"abstract":"<div><div>Accurate and early diagnosis of Depression and Anxiety is met with the challenge of comorbid presentations and the neglect of the basic disturbances of self in current diagnostic criteria. Here, we review studies employing functional magnetic resonance imaging (fMRI) with self-based tasks in major depressive disorder (MDD) and anxiety disorders (AD) to determine the transdiagnostic and differential-diagnostic applicability of neural markers related to the self. This systematic review identified three main findings: (I) Large-scale brain-wide changes related to self-dysfunction overlap significantly between MDD and AD. (II) Regional changes are unspecific to tasks and stimuli confirming their specificity to the self as distinguished from other cognitive functions. (III) MDD affects regions related to emotional-cognitive processing like the anterior cingulate cortex, while AD involves prefrontal and insular regions associated with interoceptive and emotional-cognitive regulation. Our systematic review shows the utility of the self as a transdiagnostic marker that exhibits neural topographic similarities across the diagnostic boundaries of MDD and AD. More fine-grained regional differences between MDD and AD can be found within their underlying large scale neural similarities, allowing for their differential-diagnostic specification. In conclusion, we demonstrate the relevance of the self as both a transdiagnostic and differential diagnostic neural marker in MDD and AD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106034"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}