Neuroscience and Biobehavioral Reviews最新文献

{"title":"The effect of psychedelic microdosing on animal behavior: A review with recommendations for the field","authors":"Omer A. Syed ,&nbsp;Rotem Petranker ,&nbsp;Benjamin Tsang","doi":"10.1016/j.neubiorev.2025.106204","DOIUrl":"10.1016/j.neubiorev.2025.106204","url":null,"abstract":"<div><div>Microdosing, the repeated use of psychedelic substances at low doses, is growing in popularity among recreational consumers. While this practice is associated with many benefits to mood, well-being and health, research in this area is in its early stages and predominantly centered on human applications. In this narrative review, we synthesize the findings from studies investigating the effects of microdosing on the behaviors of three animal species: rats, mice, and zebrafish. A total of 12 studies were identified that implemented a microdosing regimen of LSD, psilocybin, or DMT in these animal models. Overall, microdosing caused little changes in behaviors associated with anxiety- and depressive-like states. Moreover, while microdosing was well-tolerated across species, further research is needed to capture specific safety concerns. Finally, we critically appraise the studies included in this review based on their methodologies and discuss further avenues of research to advance the preclinical literature on psychedelic microdosing. Specifically, we recommend that future research prioritize the replication of existing findings to inform the development of robust study designs and dosing protocols, as well as establish standardized methodologies to enable effective comparisons across different animal models. Furthermore, future investigations should explore the therapeutic potential of mescaline microdosing, examine sex-dependent effects, and extend research to additional models of psychiatric conditions, including those related to obsessive-compulsive disorder and post-traumatic stress disorder.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106204"},"PeriodicalIF":7.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of microbiome pathophysiology with social activity and behavior are mediated by epigenetic modulations: Avenues for designing innovative therapeutic strategies","authors":"Shabnam Nohesara ,&nbsp;Hamid Mostafavi Abdolmaleky ,&nbsp;Faith Dickerson ,&nbsp;Adrian A. Pinto-Tomas ,&nbsp;Dilip V. Jeste ,&nbsp;Sam Thiagalingam","doi":"10.1016/j.neubiorev.2025.106208","DOIUrl":"10.1016/j.neubiorev.2025.106208","url":null,"abstract":"<div><div>A number of investigations have shown that gut microbiome influences humans’ ability to communicate with others, and impairments in social interactions are linked to alterations in gut microbiome composition and diversity, via epigenetic mechanisms. This article reviews the links among gut microbiome, social behavior, and epigenetic shifts relevant to gut microbiome–derived metabolites. First, we discuss how different social determinants of health, such as socioeconomic status, diet, environmental chemicals, migration, ecological conditions, and seasonal changes may influence gut microbiome composition, diversity, and functionality, along with epigenetic alterations and thereby affect social behavior. Next, we consider how gut microbiome–derived metabolites, diet, probiotics, and fecal microbiome transplantation may reduce impairments in social interactions through the adjustment of epigenetic aberrations (e.g., DNA methylation, histone modifications, and microRNAs expression) which may suppress or increase gene expression patterns. Finally, we present the potential benefits and unresolved challenges with the use of gut microbiome-targeted therapeutics in reducing social deficits.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106208"},"PeriodicalIF":7.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on clinical therianthropy and a proposal to conceptualize zoomorphism as a diagnostic spectrum","authors":"Jan Dirk Blom ,&nbsp;Brian A. Sharpless","doi":"10.1016/j.neubiorev.2025.106193","DOIUrl":"10.1016/j.neubiorev.2025.106193","url":null,"abstract":"<div><div>Clinical therianthropy involves the delusional belief that one transforms into an animal and assumes its characteristics. We conducted a systematic review and identified 77 published cases. Of the many theriotypes reported, 68 % involved transformations into canines. Men debuted at a significantly earlier age than women; duration ranged from days (25 %) to weeks (12 %), months (33 %), and years (31 %). Associated conditions included psychotic disorders (41 %), psychotic depression (24 %), bipolar disorder (18 %), and Cotard’s syndrome (12 %), while 16 % engaged in other-directed physical violence. Treatment resulted in full remission (58 %) and partial remission (33 %) of the symptoms of clinical therianthropy, although the associated conditions were often chronic in nature and overall prognosis tended to be poor. We also discuss the history and reported etiologies of clinical therianthropy and propose a ‘two-hit’ pathophysiological model involving cenesthesiopathy and delusion formation. Diagnostic, therapeutic and forensic implications are also discussed. Lastly, we provide suggestions for a diagnostic spectrum that includes clinical and non-clinical cases, the latter comprising therians, furries, otherkin, and other people who experience varying levels of identification with animals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106193"},"PeriodicalIF":7.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overlooked role of metabolic disorders in bipolar disorder","authors":"Anouar Khayachi ,&nbsp;Abraham Nunes ,&nbsp;Martin Alda ,&nbsp;Guy A. Rouleau","doi":"10.1016/j.neubiorev.2025.106203","DOIUrl":"10.1016/j.neubiorev.2025.106203","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106203"},"PeriodicalIF":7.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From data to discovery: Technology propels speech-language research and theory-building in developmental science","authors":"Zuzanna Laudańska ,&nbsp;Anna Caunt ,&nbsp;Alejandrina Cristia ,&nbsp;Anne Warlaumont ,&nbsp;Katerina Patsis ,&nbsp;Przemysław Tomalski ,&nbsp;Petra Warreyn ,&nbsp;Drew H. Abney ,&nbsp;Jeremy I. Borjon ,&nbsp;Manu Airaksinen ,&nbsp;Emily JH Jones ,&nbsp;Sven Bölte ,&nbsp;Magdalena Dall ,&nbsp;Daniel Holzinger ,&nbsp;Luise Poustka ,&nbsp;Herbert Roeyers ,&nbsp;Sam Wass ,&nbsp;Dajie Zhang ,&nbsp;Peter B. Marschik","doi":"10.1016/j.neubiorev.2025.106199","DOIUrl":"10.1016/j.neubiorev.2025.106199","url":null,"abstract":"<div><div>Research on speech and language development has a long history, but in the past decade, it has been transformed by advances in recording technologies, analysis and classification tools, and AI-based language models. We conducted a systematic literature review to identify recently developed (semi-)automatic tools for studying speech-language development and learners' environments in infants and children under the age of 5 years. The Language ENvironment Analysis (LENA) system has been the most widely used tool, with more and more alternative free- and/or open-source tools emerging more recently. Most studies were conducted in naturalistic settings, mostly recording longer time periods (daylong recordings). In the context of vulnerable and clinical populations, most research so far has focused on children with hearing loss or autism. Our review revealed notable gaps in the literature regarding cultural, linguistic, geographic, clinical, and social diversity. Additionally, we identified limitations in current technology—particularly on the software side—that restrict researchers from fully leveraging real-world audio data. Achieving global applicability and accessibility in daylong recordings will require a comprehensive approach that combines technological innovation, methodological rigour, and ethical responsibility. Enhancing inclusivity in participant samples, simplifying tool access, addressing data privacy, and broadening clinical applications can pave the way for a more complete and equitable understanding of early speech and language development. Automatic tools that offer greater efficiency and lower cost have the potential to make science in this research area more geographically and culturally diverse, leading to more representative theories about language development.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106199"},"PeriodicalIF":7.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents","authors":"Chad A. Brunswick ,&nbsp;Catherine M. Carpenter ,&nbsp;Nancy A. Dennis ,&nbsp;Janine L. Kwapis","doi":"10.1016/j.neubiorev.2025.106195","DOIUrl":"10.1016/j.neubiorev.2025.106195","url":null,"abstract":"<div><div>Memory is a reconstructive and continuous process that enables existing information to be modified in response to a changing environment. Being able to dynamically update outdated memories is critical to an organism’s survival. Memory modifications have been extensively studied in both rodents and humans, and prior work has revealed many regional, cellular, neurotransmitter, and subcellular molecular mechanisms underlying this process. However, these diverse bodies of literature have not yet been fully integrated into a comprehensive cross-species review. Integrating the finding across rodent and human work is important for furthering our understanding of memory modifications and the underlying neural mechanisms that support memory modification in both species. Here, we discuss advances in our understanding of adaptive and maladaptive memory modifications in terms of both underlying mechanisms (regional, cellular, and molecular) and behavioral outcomes. By emphasizing findings from both humans and rodents, the two major model systems in which memory modifications have been studied, we are able to highlight converging mechanisms and point to open questions in the field. Specifically, we discuss the major findings from several memory paradigms including declarative, aversive and procedural memory designs and highlight paradigms and models that have been readily translated between rodent and human models. Ultimately, this review identifies key parallels underlying memory updating across species, paradigms, tasks, and models.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106195"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active information sampling in health and disease","authors":"Bahaaeddin Attaallah ,&nbsp;Pierre Petitet ,&nbsp;Masud Husain","doi":"10.1016/j.neubiorev.2025.106197","DOIUrl":"10.1016/j.neubiorev.2025.106197","url":null,"abstract":"<div><div>Active information gathering is a fundamental cognitive process that enables organisms to navigate uncertainty and make adaptive decisions. Here we synthesise current knowledge on the behavioural, neural, and computational mechanisms underlying information sampling in healthy people and across several brain disorders. The role of cortical and subcortical regions spanning limbic, insular, fronto-parietal, and striatal systems is considered, along with the contributions of key neurotransmitters involving norepinephrine, dopamine, and serotonin. We also examine how various clinical conditions, including schizophrenia, obsessive-compulsive disorder, and Parkinson’s disease have an impact on information gathering behaviours. To account for the findings, we outline a neuroeconomic perspective on how the brain may evaluate the costs and benefits of acquiring information to resolve uncertainty. This work highlights how active information gathering is a crucial brain process for adaptive behaviour in healthy individuals and how its breakdown is relevant to several psychiatric and neurological conditions. The findings have important implications for developing novel computational assays as well as targeted interventions in brain disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106197"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-intervention neuroimaging effects of psychosocial interventions aimed at promoting resilience in children and adolescents under psychological stress: A systematic review","authors":"Nitish Jawahar ,&nbsp;Bavesh Jawahar ,&nbsp;Kapil Sayal ,&nbsp;Dorothee P. Auer","doi":"10.1016/j.neubiorev.2025.106196","DOIUrl":"10.1016/j.neubiorev.2025.106196","url":null,"abstract":"<div><div>Childhood and adolescence are neurodevelopmentally critical periods, during which psychological adversity can increase the risk of subsequent mental health difficulties. However, the increased neuroplasticity during this window also confers potential for developing resilience, which is now seen as a dynamic process of adapting to adversity. This pre-registered systematic review (PROSPERO-CRD42024537715) summarises the post-intervention neuroimaging outcomes of non-invasive, non-pharmacological interventions aimed at promoting resilience in samples with a mean age of &lt; 25 years exposed to any explicit psychological stress. Studies involving traumatic or focal brain lesions were excluded. MEDLINE, PsycINFO and CENTRAL databases were searched from inception to 14/7/2024. Magnetic Resonance Imaging (MRI) outcomes were the primary focus. Risk of bias was assessed against adapted Joanna Briggs Institute checklist items. A narrative synthesis was conducted due to study heterogeneity. We identified 13 eligible studies: 1 reporting structural and diffusion-weighted MRI (performed after 2 years of intervention), 1 resting-state fMRI (14 years after end of intervention) and 11 task-based fMRI metrics (ranging from immediately post-intervention to 8 years after end of intervention). Resilience interventions reduce limbic activity (thalamus, amygdala and right anterior insula) in task-based fMRI. In older adolescents, social, mindfulness, and exercise interventions strengthen Prefrontal Cortex(PFC)-limbic connectivity, decreasing limbic activity. Evidence in younger adolescents is sparse, showing mixed effects on PFC-limbic connectivity. Five studies were at high risk of bias; the most common limitation was no pre-intervention MRI scans. Overall, this study summarises promising mechanisms, as demonstrated on neuroimaging, through which resilience can be enhanced in stressed youth through psychosocial interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106196"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring genetic and epigenetic markers for predicting or monitoring response to cognitive-behavioral therapy in obsessive-compulsive disorder: A systematic review","authors":"Yu Chen ,&nbsp;Pengchong Wang ,&nbsp;Zhanjiang Li","doi":"10.1016/j.neubiorev.2025.106192","DOIUrl":"10.1016/j.neubiorev.2025.106192","url":null,"abstract":"<div><div>Growing evidence has identified potential biomarkers of cognitive-behavioural therapy (CBT) efficacy in obsessive-compulsive disorder (OCD). Genetic and epigenetic mechanisms (e.g., polymorphisms, DNA methylation) contribute to OCD pathogenesis and CBT response variability, establishing them as a key research focus. To evaluate their associations with CBT outcomes in OCD, we conducted a systematic review of PubMed, Web of Science, CNKI, and Cochrane Library (from inception to January 2025), identifying eight studies that met rigorous inclusion criteria. The identified predictors included: (1) Genetic polymorphisms (<em>BDNF</em>); (2) Epigenetic modifications (DNA methylation of <em>MAOA</em>, <em>SLC6A4</em>, <em>OXTR</em>, <em>PIWIL1</em>, <em>MIR886</em>, <em>PLEKHA1</em>, <em>KCNQ1</em>, <em>TRPM8</em>, <em>HEBP1</em>, <em>HTR7P1</em>, <em>MAPK8IP3</em>, <em>ENAH</em>, <em>RABGGTB</em> (<em>SNORD45C</em>), <em>MYEF2</em>, <em>GALK2</em>, <em>CEP192</em>, and <em>UIMC1</em>). These markers may influence neural plasticity, neurotransmitter regulation, and related processes, providing molecular substrates for the observed treatment effects. Converging evidence suggests that distinct neurocognitive mechanisms may mediate CBT efficacy in OCD, particularly fear extinction learning and goal-directed behaviors (GDBs), which we analyze mechanistically. Future studies should integrate polygenic risk scores (PRS) with functional neuroimaging to dissect individual variability in CBT response, mainly through cortico-striato-thalamo-cortical (CSTC) circuit profiling. To our knowledge, this is the first systematic review synthesizing genetic and epigenetic predictors of CBT response in OCD; these findings provide compelling evidence for biomarkers for CBT personalization in OCD, advancing a novel precision psychiatry framework.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106192"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cerebellum in frontotemporal dementia: From neglected bystander to potential neuromodulatory target. A narrative review","authors":"Annibale Antonioni ,&nbsp;Emanuela Maria Raho ,&nbsp;Danny Adrian Spampinato ,&nbsp;Enrico Granieri ,&nbsp;Luciano Fadiga ,&nbsp;Francesco Di Lorenzo ,&nbsp;Giacomo Koch","doi":"10.1016/j.neubiorev.2025.106194","DOIUrl":"10.1016/j.neubiorev.2025.106194","url":null,"abstract":"<div><h3>Background</h3><div>Though cortical changes in frontotemporal dementia (FTD) are well-documented, the cerebellum's role, closely linked to these areas, remains unclear.</div></div><div><h3>Objectives</h3><div>To provide evidence on cerebellar involvement in FTD across clinical, genetic, imaging, neuropathological, and neurophysiological perspectives. Additionally, we sought evidence supporting the application of cerebellar non-invasive brain stimulation (NIBS) in FTD for both diagnostic and therapeutic purposes.</div></div><div><h3>Methods</h3><div>We performed a literature review using MEDLINE (via PubMed), Scopus, and Web of Science databases.</div></div><div><h3>Results</h3><div>We emphasized the involvement of specific cerebellar regions which differentiate each FTD subtypes and may account for some of the characteristic symptoms. Furthermore, we highlighted peculiarities in FTD genetic alterations. Finally, we outlined neurophysiological evidence supporting a role for the cerebellum in FTD pathogenesis.</div></div><div><h3>Conclusion</h3><div>The cerebellum is critically involved in the FTD spectrum. Moreover, it can be speculated that cerebellar modulation, as already shown in other neurodegenerative disorders, could restore the interneuronal intracortical circuits typically impaired in FTD patients, providing clinical improvements and fundamental outcome measures in clinical trials.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106194"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}