Neuroscience and Biobehavioral Reviews最新文献

{"title":"Systematic review: Biopsychosocial factors related to attention-deficit/hyperactivity disorder in children/adolescents with Neurofibromatosis type 1","authors":"Yang Hou ,&nbsp;Liyan Yu ,&nbsp;Matthew R. Jamnik ,&nbsp;Dan Liu ,&nbsp;Emma Wilson-Lemoine ,&nbsp;Xian Wu ,&nbsp;Julia Moreira ,&nbsp;Benjamin Felipe Mujica ,&nbsp;Elora Shelly Mukhopadhyay ,&nbsp;Angelena Novotney ,&nbsp;Luke Spoto ,&nbsp;Michael Peper ,&nbsp;Jonathan M. Payne","doi":"10.1016/j.neubiorev.2025.106355","DOIUrl":"10.1016/j.neubiorev.2025.106355","url":null,"abstract":"<div><div>This systematic review was conducted to provide a comprehensive summary of biopsychosocial factors associated with attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with Neurofibromatosis Type 1 (NF1), and identify key limitations and gaps in the current literature. Systematic literature searches were conducted in Scopus, PsycINFO, Web of Science, PubMed, and ProQuest Dissertations and Theses Global in March 2024. The searches identified 2345 unique articles. Two researchers independently screened articles and extracted data. Inclusion criteria were met by 68 articles. We synthesized results across studies in a narrative format, following the Guidance on the Conduct of Narrative Synthesis in Systematic Reviews. Based on the biopsychosocial model of mental health, we grouped study findings on factors associated with ADHD into broad categories of biological (<em>n</em> = 33), psychological (<em>n</em> = 47), and social factors (<em>n</em> = 13), which were further divided into subcategories. Findings varied across biopsychosocial factors, ADHD-related variables (inattention, hyperactivity, impulsivity symptoms, or ADHD diagnosis), measurement methods, study designs, and statistical approaches. Psychological factors (e.g., executive functioning, IQ) were most commonly studied. Findings revealed consistent evidence for the link between informant-reported executive functioning problems and ADHD, whereas performance-based cognitive measures generally showed no significant associations. Most studies are cross-sectional and have small and nonrepresentative samples. Methodological limitations in previous studies hinder definitive conclusions on biopsychosocial factors associated with ADHD in NF1. Future research should use larger samples and longitudinal or experimental designs, explore understudied biological and social factors, and incorporate new technologies to improve understanding and interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106355"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of motor dysfunction in functional neurological disorder: A narrative review","authors":"Alfred Pak-Kwan Lo ,&nbsp;Maryam Homayoun ,&nbsp;Alec J. Jamieson ,&nbsp;Ben J. Harrison ,&nbsp;Richard A. Kanaan","doi":"10.1016/j.neubiorev.2025.106358","DOIUrl":"10.1016/j.neubiorev.2025.106358","url":null,"abstract":"<div><div>One of the characteristic presentations of functional neurological disorder (FND) is with motor symptoms, such as weakness and tremor. While these symptoms are both common and disabling, how they arise at a mechanistic level remains unclear. This review provides an up-to-date account of the underpinnings of motor dysfunction in FND by integrating findings from neuroimaging, physiology, genetic, brain stimulation, and behavioral studies. A literature search was conducted systematically in MEDLINE and PsycINFO, resulting in 168 studies that met our inclusion criteria. Results generally suggest that patients, compared to healthy controls, have difficulties in predicting their own actions and detecting their bodily cues, limiting their capability for action inference. The literature also shows that patients tend to be hypersensitive to stress, accompanied by heightened linkage between their emotion and motor systems, when compared to healthy controls. It is also evident that, relative to controls, patients exhibit distorted action selection and excessive self-monitoring, implying abnormalities in top-down control. We discuss how these abnormal information processing patterns relate to specific motor symptoms experienced by patients with FND, thereby offering a framework that may facilitate the treatment of these symptoms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106358"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Touch facilitates newborns’ self-regulation: Systematic review of multidimensional arousal outcomes","authors":"Irene Valori ,&nbsp;Jasmin L. Merkel ,&nbsp;Giovanna Furlan ,&nbsp;Tobias Grossmann ,&nbsp;Merle T. Fairhurst","doi":"10.1016/j.neubiorev.2025.106353","DOIUrl":"10.1016/j.neubiorev.2025.106353","url":null,"abstract":"<div><div>During the first month of life, exchanges between newborns and caregivers focus on helping babies regulate their physiological and behavioural states. Touch and bodily contact play a special role in facilitating arousal regulation and are often used to promote bonding, support at-risk babies, and manage pain. Here, we systematically review the extant evidence on the effects of touch interventions for newborns, specifically focusing on self-regulation and arousal as outcome measures. Seventy-two experimental studies met our inclusion criteria, comparing touch and control groups or within-subject conditions across a variety of physiological and behavioural outcomes. The types of touch interventions employed include skin-to-skin care, Kangaroo Care, massage therapy, Gentle Human Touch, and Yakson. Outcome measures include heart rate and heart rate variability, blood oxygenation and respiration rate, body temperature regulation, cortisol levels, and behavioural states (e.g., sleep and crying patterns). Most studies implemented touch interventions on premature babies and measured outcomes within the first month of life. Only a minority monitored the long-term effects of interventions or explored facilitating factors such as multisensory aspects, caregiver satisfaction, and sensitivity to the baby’s signals. Overall, the findings consistently show the benefits of touch in promoting the immediate self-regulation skills of newborns, particularly supporting the use of tactile interventions for premature babies and neonatal pain management in clinical contexts. Future research should further investigate the long-term, cascading effects of touch interventions on broader dimensions of child development and the child-caregiver dyad’s well-being as a whole.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106353"},"PeriodicalIF":7.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response effects of exogenous oxytocin on social cognition: A systematic review","authors":"Simon Barton ,&nbsp;Annika Pruin ,&nbsp;Janna Schulze ,&nbsp;Maximilian Kiebs ,&nbsp;Dirk Scheele ,&nbsp;René Hurlemann","doi":"10.1016/j.neubiorev.2025.106350","DOIUrl":"10.1016/j.neubiorev.2025.106350","url":null,"abstract":"<div><div>Oxytocin, a neuropeptide known for its role in social bonding, has garnered considerable attention for its potential to enhance social cognition in humans. Intranasal administration of oxytocin is the standard method in exogenous oxytocin research. This systematic review critically examines the effects of exogenously administered oxytocin on three core components of social cognition: emotion recognition, empathy, and interpersonal trust. By comparing findings across studies using intranasal oxytocin doses ranging from 1 IU to 48 IU in healthy adult humans, we evaluate evidence for a potential dose-response relationship. The majority of studies administered a standard dose of 24 IU and generally reported significant improvements in emotion recognition, empathy, and trust. However, divergent findings at this dose have also been observed. Evidence for both lower and higher doses remains mixed. Much of the support for the Inverted-U Curve hypothesis - suggesting that oxytocin’s effects follow a nonlinear trajectory with optimal outcomes at moderate doses - comes from studies lacking direct dose comparisons. Furthermore, the effects of oxytocin on social cognition appear to be strongly moderated by individual and contextual factors, raising questions about the generalizability of the Inverted-U model. Additional research is necessary to clarify the conditions under which dose-dependent effects occur.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106350"},"PeriodicalIF":7.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Links between auditory verbal hallucinations and auditory emotional perception: A systematic review","authors":"Maria Amorim ,&nbsp;Margarida Marques ,&nbsp;Sonja A. Kotz ,&nbsp;Ana P. Pinheiro","doi":"10.1016/j.neubiorev.2025.106351","DOIUrl":"10.1016/j.neubiorev.2025.106351","url":null,"abstract":"<div><div>Auditory verbal hallucinations (AVH) represent the experience of hearing voices in the absence of a corresponding external stimulus. Previous studies have posited a link between AVH and changes in emotion perception. We conducted a systematic review to examine whether such alterations relate consistently to AVH, and to what extent they depend on the participants’ clinical status and stimulus characteristics (i.e., sensory modality, complexity, and emotional valence).</div></div><div><h3>Method</h3><div>We searched the Web of Science and Pubmed databases for articles examining the relationship between emotion perception and AVH.</div></div><div><h3>Results</h3><div>The final sample included 18 articles and a total of 21 experimental tasks. Lower emotion recognition accuracy and alterations in neural indices of emotion decoding from negative vocal stimuli were associated with AVH.</div></div><div><h3>Conclusion</h3><div>Altered emotion perception in voice hearers is modulated by emotional valence and complexity: atypical performance was observed more systematically for speech and negative stimulus valence. Despite methodological differences between studies, altered perception of negative vocal emotions in AVH was observed in most studies. We present recommendations for future studies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106351"},"PeriodicalIF":7.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception abnormalities and skin-picking disorder: Systematic review and narrative synthesis of preliminary evidence","authors":"Joanna Kłosowska ,&nbsp;Magdalena Żegleń ,&nbsp;Julia Badzińska ,&nbsp;Katarzyna Prochwicz","doi":"10.1016/j.neubiorev.2025.106349","DOIUrl":"10.1016/j.neubiorev.2025.106349","url":null,"abstract":"<div><div>A growing body of research suggests that disrupted interoception plays an important role in various mental disorders, including Obsessive-Compulsive and Related Disorders. However, interoceptive abnormalities in Skin Picking Disorder (SPD) remain unexplored. This study aimed to evaluate and synthesize existing evidence regarding interoceptive disruptions in SPD, adopting a broad definition of interoception encompassing certain types of skin-mediated signals. We searched five databases (PubMed, Scopus, EBSCO, Web of Science, Embase) for articles reporting associations between SPD and any interoceptive modality/dimension. Citation tracking was also conducted. The database search identified 118 articles, and citation tracking additional nine. Eight distinct studies, involving 1338 participants (462 with SPD) met the inclusion criteria. Findings indicated disrupted affective touch processing in SPD. Pain sensitivity did not differentiate individuals with SPD from controls. Limited evidence indicated reduced cardiac interoceptive accuracy and lower emotional awareness in SPD, alongside a link between heightened reliance on bodily signals and decreased control over picking. A post-hoc analysis suggested possible disruptions in itch processing. Overall, preliminary evidence indicates interoceptive disruptions in SPD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106349"},"PeriodicalIF":7.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential","authors":"Neal A. Jha ,&nbsp;Samantha M. Ayoub ,&nbsp;Arthur L. Brody ,&nbsp;Jared W. Young","doi":"10.1016/j.neubiorev.2025.106348","DOIUrl":"10.1016/j.neubiorev.2025.106348","url":null,"abstract":"<div><div>Approximately half of people with HIV (PWH) experience neurocognitive impairment (NCI), despite antiretroviral therapies that have turned what was formerly a death sentence to a chronic illness. No targeted treatments exist for HIV-associated NCI, impacting long-term quality of life. Smoking rates in PWH are nearly double those of the general population, and with evidence for pro-cognitive effects of nicotine, this may reflect self-medication. However, clinical studies yield inconsistent findings—some showing benefits, others reporting harm—likely due to variability in nicotine exposure methods, cognitive testing paradigms, withdrawal states, and confounding comorbidities. In contrast, animal studies offer a more controlled framework to isolate the effects of nicotine. Preclinical models suggest that nicotine may mitigate HIV-associated cognitive deficits by acting on α7 nicotinic acetylcholine receptors (nAChRs), leading to reduced neuroinflammation. These findings highlight the therapeutic potential of targeting nAChRs, though mechanisms remain incompletely understood. Despite the clarifications offered by preclinical work, translation to human models remains challenging, with key challenges including variability in defining nicotine use, route of administration, confirming mechanism of action, and controlling for comorbidities. Future studies could utilize vaping mechanisms, self-administration paradigms, and translational cognitive assessments to clarify the potential for nicotine and nAChR agonists to attenuate NCI. While nicotine-based therapies show promise, their risks—particularly smoking-related health complications in PWH—must be considered, hence the need to discover potential pro-cognitive mechanisms of action.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106348"},"PeriodicalIF":7.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive disorder – A state-of-the-art review","authors":"Dominique Endres ,&nbsp;Miriam A. Schiele ,&nbsp;Katharina von Zedtwitz ,&nbsp;Raphael J. Dressle ,&nbsp;Alexander Maier ,&nbsp;Fritz Hohagen ,&nbsp;Juan C. Baldermann ,&nbsp;Volker A. Coenen ,&nbsp;Lena Jelinek ,&nbsp;Katharina Domschke ,&nbsp;Ulrich Voderholzer","doi":"10.1016/j.neubiorev.2025.106320","DOIUrl":"10.1016/j.neubiorev.2025.106320","url":null,"abstract":"<div><div>Obsessive-compulsive disorder (OCD) is a severe and common mental illness associated with high rates of treatment resistance. Quality of life is significantly impaired by OCD, and there is a high risk of chronification without treatment. The rationale of this narrative review is to present the state of the art about OCD regarding its A) relevance, course, and impact on wellbeing, B) risk factors, C) etiopathophysiology, D) clinical manifestation and classification criteria, E) comorbidity and differential diagnostics, F) diagnostic investigations, G) secondary obsessive-compulsive syndromes, and H) treatment approaches. Finally, the consequences of novel developments for the diagnosis and treatment of individual patients are summarized, and the needs for further research are outlined.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106320"},"PeriodicalIF":7.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of social motor coordination in autism: A systematic review and meta-analysis of fNIRS studies","authors":"Ga Eul Yoo,&nbsp;Eun Young Lee,&nbsp;Eunsu Lee","doi":"10.1016/j.neubiorev.2025.106347","DOIUrl":"10.1016/j.neubiorev.2025.106347","url":null,"abstract":"<div><div>This study aimed to provide a comprehensive overview of how individuals with autism spectrum condition (ASC) process social motor coordination, focusing on joint action and its neural correlates, as examined through functional near-infrared spectroscopy (fNIRS) in comparing to their neurotypical (NT) counterparts. Eleven studies were analyzed, with nine included in the meta-analysis. The results identified the inferior parietal lobule (IPL) and superior temporal sulcus (STS) as significant moderators explaining group differences in cortical activation during joint action. Specifically, individuals with ASC showed increased IPL activation and reduced STS activation, indicating a greater reliance on kinematic processing and diminished engagement in encoding and integrating socially relevant information. Although the pooled effect size for inter-brain synchrony (IBS) was not statistically significant, descriptive analyses showed a trend toward reduced reciprocal processing in ASC, particularly in predicting and aligning with a partner’s mental states, as supported by decreased IBS in the temporoparietal junction (TPJ). Furthermore, a visual inspection of behavioral and neural outcomes by autism severity exhibited distinct tendencies. Individuals with mild symptoms demonstrated different neural-behavioral associations compared to those with moderate-to-severe symptoms, suggesting that symptom severity influences how neural processing supports joint action. These findings highlight the differential involvement of neural systems in joint actions among individuals with ASC depending on task type and autism severity, and emphasize the distinction between intra- and inter-personal processing. By integrating these findings, this study offers a more integrative perspective on social motor coordination in ASC as a complex, multi-dimensional process.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106347"},"PeriodicalIF":7.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social evaluation of skill and competence in primates","authors":"William O’Hearn ,&nbsp;Marie Hirel ,&nbsp;Stefanie Keupp ,&nbsp;Julia Fischer","doi":"10.1016/j.neubiorev.2025.106346","DOIUrl":"10.1016/j.neubiorev.2025.106346","url":null,"abstract":"<div><div>Social life is a continuous interplay of observing and interacting with conspecifics, predicting their behavior, and responding to their actions. This review explores the concept of social evaluation, which we construe as the cognitive process of acquiring and processing social information to generate social knowledge. Social evaluation has been a topic of interest in various research streams, including behavioral ecology, behavioral economics, developmental psychology, and comparative psychology. We review studies on the attribution of prosociality and competence in humans and nonhuman animals and then outline the cognitive mechanisms invoked in social evaluation. We focus on how animals assess skill and competence, drawing on our studies of chimpanzees, macaques, and baboons. The animals used outcome-based learning and inference-based processes to evaluate others, but distinguishing between different cognitive mechanisms remains challenging. We discuss the limitations of current methodologies, including experimental constraints in both captive and wild settings. Finally, we advocate for a unified framework, emphasizing the need to integrate both proximate and ultimate perspectives in studies of social evaluation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106346"},"PeriodicalIF":7.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}