Neuroscience and Biobehavioral Reviews最新文献

{"title":"Optimal exercise dose and type for improving schizophrenia symptoms in adults: A systematic review and Bayesian network meta-analysis","authors":"Yong Yang ,&nbsp;Yuan Yuan ,&nbsp;HaoYang Zhang ,&nbsp;XueYing Fu ,&nbsp;Tao Wang ,&nbsp;JunYu Wang ,&nbsp;Chu-Chun Fang","doi":"10.1016/j.neubiorev.2024.105896","DOIUrl":"10.1016/j.neubiorev.2024.105896","url":null,"abstract":"<div><h3>Background</h3><div>Exercise has shown promise in aiding patients with schizophrenia, potentially improving symptoms, quality of life, mood, and cognition. This review evaluates the effectiveness of different physical activities in this context, aiming to guide treatment and research towards the most beneficial exercise interventions for schizophrenia management.</div></div><div><h3>Methods</h3><div>This systematic review and network meta-analysis searched PubMed, MEDLINE, Embase, PsycINFO, Cochrane CENTRAL, Web of Science, and CNKI up to March 30, 2024. We utilized the \"gemtc,\" \"MBNMAdose,\" \"metafor,\" and \"ggplot2\" packages for data analysis in R. Additionally, our results were reported as standardized mean differences with 95 % confidence intervals. To assess the risk of bias in the included studies, we used ROB2 and CINeMA tools.</div></div><div><h3>Results</h3><div>In the results section of our systematic review and network meta-analysis, we analyzed data from 47 studies involving 4031 participants. Our findings indicate that among the various exercise interventions examined for schizophrenia patients, yoga emerged as the most effective in improving Total symptoms, positive and negative symptoms. RT+AE (Resistance Training + Aerobic Exercise) showed the greatest improvement in general symptoms, whereas Tai Chi (TC) was the least effective. In terms of improvement of cognitive functions and depression, AE proved the most beneficial, while TC was found to be the least effective. EX+PT (Physical Exercise + Psychological Nursing) was identified as the most effective approach for improved quality of life, with TC again showing the least efficacy. The optimal total exercise dose to improve the patient's total symptoms was estimated to be 1200 METs-min/week. (SMD: −0.956, 95 %Crl: −1.376 to −0.536).</div></div><div><h3>Conclusions</h3><div>Yoga, RT+AE, EX+PT, and Baduanjin have demonstrated enhanced efficacy in alleviating clinical symptoms, quality of life, depressive states, and cognitive functions in patients with schizophrenia. We identified optimal overall exercise doses and provided exercise guidance recommendations for healthcare professionals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105896"},"PeriodicalIF":7.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central effects of acute intranasal insulin on neuroimaging, cognitive, and behavioural outcomes: A systematic review","authors":"Aniqa Tabassum ,&nbsp;Sebastian Badulescu ,&nbsp;Evanka Singh ,&nbsp;Renee Asoro ,&nbsp;Roger S. McIntyre ,&nbsp;Kayla M. Teopiz ,&nbsp;Cristian-Daniel Llach ,&nbsp;Hiya Shah ,&nbsp;Rodrigo B. Mansur","doi":"10.1016/j.neubiorev.2024.105907","DOIUrl":"10.1016/j.neubiorev.2024.105907","url":null,"abstract":"<div><div>The distribution of insulin receptors throughout the brain implicates insulin in physiological functions and disease states, including cognition, appetite, mood, and metabolic disorders. Intranasally administered insulin offers a non-invasive approach for isolating and investigating brain insulin action. This systematic review synthesized the effects of acute intranasal insulin on neuroimaging, cognitive, and behavioural outcomes reported in 48 studies in adults. Age, sex, body mass index, and insulin resistance were found to moderate brain insulin action. Neuroimaging studies showed insulin affects brain activity, cerebral blood flow, and functional connectivity in regions like the hypothalamus, amygdala, and insula. Insulin also modified cognitive function, eating behaviour, and the stress response. Nonetheless, inconsistencies in study designs, dosages, and outcome measures necessitate standardized methodologies to better understand central insulin action. Taken together, insulin’s ability to modify stress and fear, appetite and eating behaviour, and cognitive function in both healthy and diseased individuals highlight its potential in the therapeutic and mechanistic exploration of highly prevalent psychiatric, metabolic, and cognitive conditions like mood disorders, obesity, and Alzheimer’s disease.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105907"},"PeriodicalIF":7.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining predictive coding accounts of typical and autistic neurocognitive development","authors":"Hannah Rapaport ,&nbsp;Paul F. Sowman","doi":"10.1016/j.neubiorev.2024.105905","DOIUrl":"10.1016/j.neubiorev.2024.105905","url":null,"abstract":"<div><div>Predictive coding has emerged as a prominent theoretical framework for understanding perception and its neural underpinnings. There has been a recent surge of interest in the predictive coding framework across the mind sciences. However, comparatively little of the research in this field has investigated the neural underpinnings of predictive coding in young neurotypical and autistic children. This paper provides an overview of predictive coding accounts of typical and autistic neurocognitive development and includes a review of the current electrophysiological evidence supporting these accounts. Based on the current evidence, it is clear that more research in pediatrics is needed to evaluate predictive coding accounts of neurocognitive development fully. If supported, these accounts could have wide-ranging practical implications for pedagogy, parenting, artificial intelligence, and clinical approaches to helping autistic children manage the barrage of everyday sensory information.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105905"},"PeriodicalIF":7.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents","authors":"Isabel Werle ,&nbsp;Leandro J. Bertoglio","doi":"10.1016/j.neubiorev.2024.105899","DOIUrl":"10.1016/j.neubiorev.2024.105899","url":null,"abstract":"<div><div>Threatening events and stressful experiences can lead to maladaptive memories and related behaviors. Existing treatments often fail to address these issues linked to anxiety/stress-related disorders effectively. This review identifies dose ranges associated with specific actions across various psychedelics. We examined psilocybin/psilocin, lysergic acid diethylamide (LSD), <em>N</em>,<em>N</em>-dimethyltryptamine (DMT), mescaline, 5-methoxy-<em>N</em>,<em>N</em>-dimethyltryptamine (5-MeO-DMT), serotonin 2 A/2 C agonists (e.g., DOI) and 3,4-methylenedioxymethamphetamine (MDMA) on aversive memory extinction and reconsolidation, learned fear, anxiety, and locomotion in rodents. Nearly 400 studies published since 1957 were reviewed. Psychedelics often show biphasic effects on locomotion at doses that enhance extinction learning/retention, impair memory reconsolidation, or reduce learned fear and anxiety. Emerging evidence suggests a dissociation between their prospective benefits and locomotor effects. Under-explored aspects include sex differences, susceptibility to interference as memories age and generalize, repeated treatments, and immediate vs. delayed changes. Validating findings in traumatic-like memory and maladaptive fear/anxiety models is essential. Understanding how psychedelics modulate threat responses and post-retrieval memory processes in rodents may inform drug development and human studies, improving therapeutic approaches for related psychiatric conditions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105899"},"PeriodicalIF":7.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisensory approach in Mental Imagery: ALE meta-analyses comparing Motor, Visual and Auditory Imagery","authors":"Elise E. Van Caenegem ,&nbsp;Marcos Moreno-Verdú ,&nbsp;Baptiste M. Waltzing ,&nbsp;Gautier Hamoline ,&nbsp;Siobhan M. McAteer ,&nbsp;Lennart Frahm ,&nbsp;Robert M. Hardwick","doi":"10.1016/j.neubiorev.2024.105902","DOIUrl":"10.1016/j.neubiorev.2024.105902","url":null,"abstract":"<div><div>Mental Imagery is a topic of longstanding and widespread scientific interest. Individual studies have typically focused on a single modality (e.g. Motor, Visual, Auditory) of Mental Imagery. Relatively little work has considered directly comparing and contrasting the brain networks associated with these different modalities of Imagery. The present study integrates data from 439 neuroimaging experiments to identify both modality-specific and shared neural networks involved in Mental Imagery. Comparing the networks involved in Motor, Visual, and Auditory Imagery identified a pattern whereby each form of Imagery preferentially recruited ‘higher level’ associative brain regions involved in the associated ‘real’ experience. Results also indicate significant overlap in a left-lateralized network including the pre-supplementary motor area, ventral premotor cortex and inferior parietal lobule. This pattern of results supports the existence of a ‘core’ network that supports the attentional, spatial, and decision-making demands of Mental Imagery. Together these results offer new insights into the brain networks underlying human imagination.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105902"},"PeriodicalIF":7.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future considerations for the Human Affectome: Reply to commentaries","authors":"Alessandra N.C. Yu ,&nbsp;Leroy Lowe ,&nbsp;Daniela Schiller","doi":"10.1016/j.neubiorev.2024.105901","DOIUrl":"10.1016/j.neubiorev.2024.105901","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105901"},"PeriodicalIF":7.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic overlap between schizophrenia spectrum disorders and Alzheimer's disease: Current evidence and future directions – An integrative review","authors":"Kazutaka Ohi ,&nbsp;Daisuke Fujikane ,&nbsp;Toshiki Shioiri","doi":"10.1016/j.neubiorev.2024.105900","DOIUrl":"10.1016/j.neubiorev.2024.105900","url":null,"abstract":"<div><p>Schizophrenia and Alzheimer's disease (AD) are distinct neurodegenerative disorders characterized by progressive cognitive deficits and structural alterations in the brain. Schizophrenia typically emerges in adolescence or early adulthood with symptoms such as hallucinations, delusions, and cognitive impairments, whereas AD primarily affects elderly individuals, causing progressive memory loss, cognitive decline, and behavioral changes. Delusional disorder, which often emerges later in life, shares some features with schizophrenia and is considered a schizophrenia spectrum disorder. Patients with schizophrenia or delusional disorder, particularly women and those aged 65 years or older, have an increased risk of developing AD later in life. In contrast, approximately 30 % of AD patients exhibit psychotic symptoms, which accelerate cognitive decline and worsen health outcomes. This integrative review explored the genetic overlap between schizophrenia spectrum disorders and AD to identify potential shared genetic factors. The genetic correlations between schizophrenia and AD were weak but positive (<em>r</em>_<em>g</em>=0.03–0.10). Polygenic risk scores (PRSs) for schizophrenia and AD indicate some genetic predisposition, although findings are inconsistent among studies; e.g., PRS-schizophrenia or PRS-AD were associated with the risk of developing psychosis in patients with AD. A higher PRS for various developmental and psychiatric disorders was correlated with an earlier age at onset of schizophrenia. Research gaps include the need for studies on the impacts of PRS-AD on the risk of schizophrenia, genetic correlations between later-onset delusional disorder and AD, and genetic relationships between AD and late-onset schizophrenia (LOS) with a greater risk of progressing to AD. Further investigation into these genetic overlaps is crucial to enhance prevention, treatment, and prognosis for affected patients.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105900"},"PeriodicalIF":7.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003695/pdfft?md5=4f9885865831e82d562532cf9f3ef8ee&pid=1-s2.0-S0149763424003695-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive endocrinology and aging in human males: An evolutionary perspective","authors":"R.G. Bribiescas","doi":"10.1016/j.neubiorev.2024.105898","DOIUrl":"10.1016/j.neubiorev.2024.105898","url":null,"abstract":"<div><div>Due to its important role in fertility, reproductive endocrine function has been subject to natural selection in all organisms including human males. Moreover, reproductive endocrine function is subject to change as males age. Indeed, the biology of aging is also subject to natural selection. As males age, hormone function such as variation in testosterone can change as the result of general somatic degradation. However these changes are not universal and can differ between human male populations depending on lifestyle and ecological context. The degree to which this variation is adaptive remains an open question but recent evolutionary anthropology research has provided some clarity. While knowledge of evolutionary approaches has limitations, the benefits of understanding the origins and comparative context of reproductive endocrine function in older human males are significant. This paper discusses our present comprehension of reproductive endocrinology and aging in human males, with a focus on human diversity across varied lifestyles, ecologies, and environments. In addition, comparative great ape research is examined. Current research challenges and future directions related to the importance of evolutionary biology and human diversity for understanding human male aging are discussed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105898"},"PeriodicalIF":7.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering functional interactions among schizophrenia-risk genes by combining behavioral genetics with cell biology","authors":"Di Ma ,&nbsp;Chen Gu","doi":"10.1016/j.neubiorev.2024.105897","DOIUrl":"10.1016/j.neubiorev.2024.105897","url":null,"abstract":"<div><div>Despite much progress in identifying risk genes for polygenic brain disorders, their core pathogenic mechanisms remain poorly understood. In particular, functions of many proteins encoded by schizophrenia risk genes appear diverse and unrelated, complicating the efforts to establish the causal relationship between genes and behavior. Using various mouse lines, recent studies indicate that alterations of parvalbumin-positive (PV+) GABAergic interneurons can lead to schizophrenia-like behavior. PV+ interneurons display fast spiking and contribute to excitation-inhibition balance and network oscillations via feedback and feedforward inhibition. Here, we first summarize different lines of genetically modified mice that display motor, cognitive, emotional, and social impairments used to model schizophrenia and related mental disorders. We highlight ten genes, encoding either a nuclear, cytosolic, or membrane protein. Next, we discuss their functional relationship in regulating fast spiking and other aspects of PV+ interneurons and in the context of other domains of schizophrenia. Future investigations combining behavioral genetics and cell biology should elucidate functional relationships among risk genes to identify the core pathogenic mechanisms underlying polygenic brain disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105897"},"PeriodicalIF":7.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is chronic pain caused by central sensitization? A review and critical point of view","authors":"Enrique Velasco ,&nbsp;Mar Flores-Cortés ,&nbsp;Javier Guerra-Armas ,&nbsp;Laura Flix-Díez ,&nbsp;Francisco Gurdiel-Álvarez ,&nbsp;Aser Donado-Bermejo ,&nbsp;Emanuel N. van den Broeke ,&nbsp;Laura Pérez-Cervera ,&nbsp;Miguel Delicado-Miralles","doi":"10.1016/j.neubiorev.2024.105886","DOIUrl":"10.1016/j.neubiorev.2024.105886","url":null,"abstract":"<div><p>Chronic pain causes disability and loss of health worldwide. Yet, a mechanistic explanation for it is still missing. Frequently, neural phenomena, and among them, Central Sensitization (CS), is presented as causing chronic pain. This narrative review explores the evidence substantiating the relationship between CS and chronic pain: four expert researchers were divided in two independent teams that reviewed the available evidence. Three criteria were established for a study to demonstrate a causal relationship: (1) confirm presence of CS, (2) study chronic pain, and (3) test sufficiency or necessity of CS over chronic pain symptoms. No study met those criteria, failing to demonstrate that CS can cause chronic pain. Also, no evidence reporting the occurrence of CS in humans was found. Worryingly, pain assessments are often confounded with CS measures in the literature, omitting that the latter is a neurophysiological and not a perceptual phenomenon. Future research should avoid this misconception to directly interrogate what is the causal contribution of CS to chronic pain to better comprehend this problematic condition.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"167 ","pages":"Article 105886"},"PeriodicalIF":7.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}