Neuroscience and Biobehavioral Reviews最新文献

{"title":"The PTCHD1 protein: a prominent actor in brain function and in neurodevelopmental disorders.","authors":"Dévina C Ung, Stéphane Martin, Yann Hérault, Frédéric Laumonnier","doi":"10.1016/j.neubiorev.2025.106307","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106307","url":null,"abstract":"<p><p>Neurodevelopmental disorders (NDDs) encompass a broad spectrum of conditions, including intellectual disability (ID), Attention Deficit Hyperactivity Disorders (ADHD) and autism spectrum disorders (ASD), often linked to disrupted synaptic functionality. Among the major NDD genes, PTCHD1 (Patched Domain Containing 1) encodes a transmembrane protein which acts as a crucial regulator of synaptic function. Mutations and microdeletions in PTCHD1 have been associated with global developmental delays such as ID, ASD, and behavioral abnormalities. This review explores the neurodevelopmental functions of PTCHD1, particularly its position within the synaptic environment, from the association with the postsynaptic proteome to the regulation of several major neuronal signaling pathways, cholesterol homeostasis and receptor trafficking. In a pathophysiological context, studies in Ptchd1 knockout mouse models revealed abnormal behavioral phenotypes, linked to synaptic impairments, including reduced excitatory postsynaptic currents and altered dendritic morphology similarly to recent results on human-derived neuronal models. By synthesizing findings from genetic, molecular, and behavioral studies, this review underscores the multifaceted roles of PTCHD1 in neurodevelopment and synaptic regulation. Understanding its function in synaptic pathways may provide crucial insights into the pathophysiology of NDDs, emphasizing the need for further research to clarify its role as a potential synaptic, orphan receptor.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106307"},"PeriodicalIF":7.9,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Responses to Visual Food Cues According to Weight and Hunger State: A Systematic Review and Meta-Analysis.","authors":"Meghedi Vartanian, Azra Jahanitabesh, Julia F Christensen, Henry Staub, Daria E A Jensen, Arno Villringer, A Veronica Witte","doi":"10.1016/j.neubiorev.2025.106301","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106301","url":null,"abstract":"<p><strong>Background: </strong>Food cue reactivity shapes eating behavior and likely relates to weight and hunger states. Functional Magnetic Resonance Imaging (fMRI) studies, however, have yielded mixed results on the underlying neural correlates. We, therefore, conducted a systematic review and meta-analysis to investigate the effect of weight and hunger on neural responses to food cues.</p><p><strong>Methods: </strong>We searched PubMed and Web of Science (2000-2022) for fMRI studies using visual food cues that reported participants' weight and hunger states (PROSPERO: CRD42022365310). The Joanna Briggs Institute critical appraisal tools and fMRI reporting standards were used to assess the risk of bias. The coordinate-based meta-analysis was conducted using GingerALE.</p><p><strong>Results: </strong>Of the 2,451 screened articles, 50 were included in the systematic review (n=1,402), and 45 in the meta-analysis (n=1,162). Results are based on both whole-brain and region-of-interest (ROI) analyses. Overall, food cues consistently activated reward, frontal, and visual brain areas, in both obesity and healthy-weight groups, though selective differences in activation strength were found. A higher-order contrast meta-analysis indicated higher activations in a parahippocampal region in obesity versus healthy weight, supported by one study. Stratified analyses indicated that during fasting, individuals with obesity showed reward area activation (16 studies, n=396), while healthy-weight individuals exhibited frontal activation (23 studies, n=429), however, higher-order contrast analyses between groups showed no significant differences.</p><p><strong>Discussion: </strong>Neural responses to food cues were consistently found in reward, frontal and visual brain areas. Some evidence indicated variation by weight and hunger states. Additional studies are needed to further clarify these neural differences.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106301"},"PeriodicalIF":7.9,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of exercise interventions on depressive and anxiety symptoms in cancer patients: A systematic review and network meta-analysis","authors":"Liang Li,&nbsp;Xuxiang Chen,&nbsp;Chengyan Yang,&nbsp;Zhengxin Hui,&nbsp;Tonggang Fan","doi":"10.1016/j.neubiorev.2025.106304","DOIUrl":"10.1016/j.neubiorev.2025.106304","url":null,"abstract":"<div><h3>Objective</h3><div>The effects of different exercise types on symptoms of depression and anxiety in patients with cancer were evaluated using a network meta-analysis (NMA) to provide an evidence-based guide for choosing appropriate exercise interventions.</div></div><div><h3>Methods</h3><div>Four databases were systematically searched from inception to October 2024. A NMA was performed using Stata 18.0 software through a random-effects model based on the frequentist framework. The study protocol was registered on the International Prospective Register of Systematic Reviews platform (Identification number: CRD42024605970).</div></div><div><h3>Results</h3><div>Seventy-two studies, totaling 6235 patients, were included to assess the effects of eight types of exercise on depressive symptoms in patients with cancer. The top three ranked by surface under the cumulative ranking curve (SUCRA) were yoga (highest probability, SUCRA=74.9 %), combination exercise (SUCRA=72.6 %), and dance (SUCRA=68.7 %). Forty-five studies, totaling 3845 patients, evaluated the effects of six types of exercise on anxiety symptoms in patients with cancer. The top three ranked by SUCRA were yoga (highest probability, SUCRA=92.5 %), aerobic exercise (SUCRA=61 %), and walking (SUCRA=54.4 %).</div></div><div><h3>Conclusions</h3><div>Yoga appears to be the most effective exercise option for alleviating symptoms of depression and anxiety in patients with cancer during rehabilitation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106304"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of non-pharmacological interventions on vagally-mediated heart rate variability (vmHRV) in individuals with depression: A systematic review and meta-analysis.","authors":"Zoey Yutong Li, Jeremy Rui Chang, Cong Wang, Minxia Jin, Ian Hoyin Cheng, Yau Suk-Yu, Cheung Wai Ming, Hector Winghong Tsang","doi":"10.1016/j.neubiorev.2025.106300","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106300","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to explore the impact of non-pharmacological interventions (NPIs) on vagally-mediated heart rate variability (vmHRV) in subjects experiencing depression. Additionally, it aims to delineate the relationship between vmHRV alterations and the severity of depressive symptoms.</p><p><strong>Methods: </strong>Search was systematically performed on RCTs studies across various databases. These included Embase, the Cochrane Central Register of Controlled Trials, Medline via EBSCO, PsycINFO accessed through ProQuest, and the Web of Science, capturing all entries until March 11, 2024.</p><p><strong>Results: </strong>The analysis revealed that NPIs generally exerted small to moderate beneficial effects on cardiac parasympathetic nervous system (PNS) markers such as the root mean square of successive differences (RMSSD) ([SMD] = 0.266, 95% confidence interval [CI] 0.029 to 0.503) and high-frequency power (HF) (SMD = 0.178, 95% CI 0.018 to 0.337). Specifically, mind-body exercises demonstrated moderate to large enhancements in RMSSD (SMD = 0.689, 95% CI 0.265 to 1.112) and a moderate improvement in HF (SMD = 0.498, 95% CI 0.134 to 0.863) immediately following the interventions. Conversely, psychological interventions did not show significant immediate post-intervention vmHRV enhancements; however, subsequent assessments revealed a moderate increase in HF (SMD = 0.477, 95% CI 0.177 to 0.786) during short-term follow-ups. Moreover, substantial correlations were observed between vmHRV improvements and reductions in depression severity.</p><p><strong>Conclusions: </strong>Our findings indicated that NPIs effectively enhance vmHRV and reduce depressive symptoms. This underscores the effectiveness of both mind-body exercises and psychological interventions. Furthermore, alterations in vmHRV may serve as viable predictors for the success of depression treatments.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106300"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ALE meta-analysis of pain processing alterations in fibromyalgia: Toward an evidence-based process model","authors":"Marco Cavicchioli ,&nbsp;Alberto Caruso ,&nbsp;Andrea Scalabrini ,&nbsp;Alessandro Torelli ,&nbsp;Sara Bottiroli ,&nbsp;Anna Pichiecchio ,&nbsp;Elena Prodi ,&nbsp;Martina Cangelosi ,&nbsp;Carlo Lai ,&nbsp;Paolo Vitali ,&nbsp;Luca Maria Sconfienza ,&nbsp;Piercarlo Sarzi-Puttini ,&nbsp;Federica Galli","doi":"10.1016/j.neubiorev.2025.106303","DOIUrl":"10.1016/j.neubiorev.2025.106303","url":null,"abstract":"<div><div>It has been hypothesized that core pain-related symptoms of fibromyalgia (FM) might be associated with alterations of pain processing mechanisms. On the one hand, several fMRI studies were conducted to evaluate possible alterations of neural responsiveness toward the presentation of different kinds of noxious stimuli among patients with FM. On the other hand, a quantitative summary of these findings is still lacking. Accordingly, it was conducted an ALE meta-analysis (FWE, p &lt; .05) of studies comparing brain responsiveness to the administration of painful stimuli between patients with FM and healthy controls (HCs). Twenty-one studies were included for meta-analytic procedures. Results showed 3 main findings: i) key areas of the pain matrix (i.e., dorsal anterior cingulate cortex [dACC], basal ganglia and thalamic nuclei) were commonly involved in pain processing in both FM patients and HCs; ii) pain processing in FM patients were characterized by a recruitment of the right insula; whereas, HCs mainly recruited prefrontal areas; iii) patients with FM, compared to HCs, showed an increased magnitude of dACC and supplementary motor area responsiveness toward the presentation of painful stimuli. These findings suggest that altered pain processing in FM is characterized by: i) an increased salience of painful stimuli, which are processed at a viscero-somatic non-mentalized level; ii) high intensity and low granularity of painful experiences accompanied by a negative valence, and modulated through maladaptive avoidance strategies; iii) the development of hypervigilance toward any potential harmful stimuli</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106303"},"PeriodicalIF":7.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of non-invasive brain stimulation in alleviating suicidal ideation and depressive symptoms in major depressive disorder: A systematic review and meta-analysis","authors":"Qian Dong ,&nbsp;Xinyu Cheng ,&nbsp;Yoshihiro Noda ,&nbsp;Georg S. Kranz ,&nbsp;Xiaoyun Guo ,&nbsp;Ti-Fei Yuan ,&nbsp;Di Zhao","doi":"10.1016/j.neubiorev.2025.106299","DOIUrl":"10.1016/j.neubiorev.2025.106299","url":null,"abstract":"<div><h3>Importance</h3><div>Suicidal ideation, intricately associated with depressive symptoms, poses a significant public health challenge. Previous clinical studies of non-invasive brain stimulation (NIBS) as a therapeutic modality have demonstrated encouraging efficacy, underscoring its potential to address both suicidal and depressive manifestations.</div></div><div><h3>Objective</h3><div>The present study aims to integrate the anti-suicidal and antidepressant effects of NIBS in depressive patients and examined the complex interplay and underlying correlations between these effects.</div></div><div><h3>Methods</h3><div>Adopting the PICOS framework and adhering to PRISMA guidelines, we conducted a comprehensive systematic review and meta-analysis, prospectively registered with PROSPERO (CRD42024506889). Our search, spanning six databases from inception to June 2025, targeted terms related to suicidal ideation, depression, and NIBS, with a focus on randomized controlled trials. Following independent screening by two assessors, we assessed the methodological rigor of the included studies using the Jadad score and the Cochrane Collaboration Risk of Bias Tool version 2 (RoB2).</div></div><div><h3>Findings</h3><div>The meta-analysis included 21 clinical trials from 19 articles (with two articles each reporting two trials), totaling 1329 participants. Results revealed a small effect size for the anti-suicide effect (SMD = −0.28, 95 % CI [−0.43, −0.14], <em>I</em>^<em>2</em> = 38.8 %, p &lt; 0.001) and a medium effect size for the antidepressant effect (SMD = −0.46, 95 % CI [−0.64, −0.28], <em>I</em>^<em>2</em> = 22.9 %, p &lt; 0.001). Subgroup analysis and meta-regression highlighted cultural background (Western or Non-western) as the most significant contributor to the heterogeneity of suicidal outcomes (<em>R</em>^<em>2</em> = 100 %). Furthermore, a positive linear correlation was observed between the two therapeutic effects (R = 0.74, p &lt; 0.001), suggesting a synergistic interplay.</div></div><div><h3>Interpretation</h3><div>Our findings emphasized the dual therapeutic potential of NIBS in mitigating suicidality and depression, offering outcome-driven evidence for clinical practice and mathematical correlation into the underlying neurobiological mechanisms. Notably, the heterogeneity analysis revealed the profound influence of sociodemographic factors, particularly cultural context, on psychological states, indicating the need for culturally tailored interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106299"},"PeriodicalIF":7.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Neuroactive steroids and the dopaminergic system","authors":"Roberto Cosimo Melcangi","doi":"10.1016/j.neubiorev.2025.106298","DOIUrl":"10.1016/j.neubiorev.2025.106298","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106298"},"PeriodicalIF":7.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-bivalent psychopathology: Rethinking mental disorders through metacontrol","authors":"Lorenza Colzato ,&nbsp;Hongchi Zhang ,&nbsp;Veit Roessner ,&nbsp;Christian Beste ,&nbsp;Bernhard Hommel","doi":"10.1016/j.neubiorev.2025.106297","DOIUrl":"10.1016/j.neubiorev.2025.106297","url":null,"abstract":"<div><div>Traditional approaches to psychopathology are based on a bivalent or binary view (healthy vs. ill), oftentimes obscuring an understanding of the heterogeneity of symptoms, fluctuations, comorbidities, and of relationships/boundaries between psychopathologies. The recent Research Domain Criteria (RDoC) approach recognizes these problems without providing mechanistic solutions. We propose a novel non-binary approach based on neurocognitive principles derived from the well-established, mechanistically transparent Metacontrol State Model of psychopathology (<em>MSMp)</em>. We suggest (1) abandoning phenomenologically-derived classifications of psychopathologies altogether; (2) explaining functional and dysfunctional behavior by means of the same theory; and (3) reconstructing behavioral observations from basic mechanisms. In line with the ambitions of RDoC, our mechanistic account allows addressing, analyzing, and treating malfunctioning at its very core—the responsible mechanism, rather than focusing on observable symptoms that may not indicate a common problem. Our theory-guided, evidence-based approach has the potential to foster a novel mechanistic understanding of psychopathology, improve diagnostic criteria weighting, and make interventions more effective.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106297"},"PeriodicalIF":7.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mating duration of male Drosophila melanogaster – A novel genetic model to study interval timing function of human brain","authors":"Zekun Wu ,&nbsp;Jiteng Shao ,&nbsp;Russell Gill ,&nbsp;Woo Jae Kim","doi":"10.1016/j.neubiorev.2025.106294","DOIUrl":"10.1016/j.neubiorev.2025.106294","url":null,"abstract":"<div><div>Time perception is essential for survival, enabling animals to estimate and control intervals between events, which underlies complex behaviors. While the brain efficiently processes temporal information across various timescales, the neural and genetic mechanisms governing this ability remain poorly understood. Although research has identified brain regions involved in timing information, genetic exploration of temporal perception lags behind, particularly outside circadian rhythms. Advances in neuroscience now allow genetic manipulation of neurotransmitters and neuropeptides to study neural circuits, but a comprehensive understanding of the molecular basis of timing remains elusive. This gap persists due to the lack of a model system that integrates behavioral, neural, and genetic data. In this context, we propose male mating duration as a novel interval timing model, as it provides a unique framework to study the interplay between genetic factors and temporal processing. Establishing such a system requires multidisciplinary efforts across computational neuroscience, molecular genetics, and behavioral genetics to uncover unifying principles of timing processes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106294"},"PeriodicalIF":7.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of miRNA expression in schizophrenia spectrum disorders across the blood and the brain","authors":"Marek Kotas ,&nbsp;Bartłomiej Stańczykiewicz ,&nbsp;Bartłomiej Sporniak ,&nbsp;Edyta Pawlak ,&nbsp;Błażej Misiak","doi":"10.1016/j.neubiorev.2025.106292","DOIUrl":"10.1016/j.neubiorev.2025.106292","url":null,"abstract":"<div><div>Several studies have investigated whether individuals with schizophrenia spectrum disorders (SSD) show altered microRNA expression. However, findings in this field have not been synthesized so far. Therefore, we performed a systematic review of studies measuring microRNA levels in the peripheral blood and brain samples of individuals with SSD and healthy controls. We searched electronic databases for studies comparing the expression of microRNAs between individuals with SSD and healthy controls. We synthesized findings with respect to concordance of alterations across the brain and peripheral blood, observations in early psychosis, medication effects, treatment resistance, molecular pathways and the utility of microRNAs as potential biomarkers. Altogether, 77 studies measuring the expression of 124 dysregulated microRNAs were included. Among them, 35 microRNAs were upregulated and 11 were downregulated in brain samples while 69 microRNAs were up-regulated and 37 were downregulated in blood samples of individuals with SSD. The most consistent finding was the overexpression of miR-181b-5p and miR-34a-5p in 8 out of 10 studies with concordant results across both types of biological materials. Both microRNAs are involved in apoptosis, neurodevelopment, and cell survival. The area under the curve (AUC) values were 0.84 ± 0.08 with the highest AUC observed for miR-199–3p (0.979). The overexpression of miR-181b-5p and miR-34a-5p is the most consistent dysregulation of microRNA expression in SSD, suggesting the significance of apoptotic, neurodevelopmental, and cell survival processes. The analysis of microRNA expression might be promising for the development of potential biomarkers for SSD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106292"},"PeriodicalIF":7.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}