Neuroscience and Biobehavioral Reviews最新文献

{"title":"Bisphenol A exposure and behavioral outcomes in children: A systematic review and meta-analysis of evidence limited to the BASC assessment tool","authors":"Patricia González-Palacios ,&nbsp;Viviana Ramírez ,&nbsp;Celia Monteagudo ,&nbsp;Alberto Zafra-Gómez ,&nbsp;Ana Rivas","doi":"10.1016/j.neubiorev.2025.106274","DOIUrl":"10.1016/j.neubiorev.2025.106274","url":null,"abstract":"<div><h3>Background</h3><div>The growing concern about exposure to endocrine disrupting chemicals (EDCs), and their effects on human health, especially the possible neurobehavioral effects in children, makes a review of the scientific evidence on the subject important. The study conducts a systematic review and applies meta-analysis to determine whether there is a relationship between bisphenol exposure and behavioral development in children, as measured by the Behavioral Assessment System for Children (BASC).</div></div><div><h3>Methods</h3><div>In June and July 2024, Scopus, Web of Science, and Medline with PubMed were the databases used to search for studies within the scope of this study. A total of 562 articles were found, of which 59 were analyzed; finally, 13 studies met the inclusion criteria for systematic review and 7 for the meta-analysis. The scales measured in the different studies have been aggression, attention, hyperactivity, depression, anxiety and somatization; behavioral indices (behavioral symptom index, externalizing and internalizing behaviors) were also analyzed.</div></div><div><h3>Results</h3><div>Most of the studies found no significant associations and no consistency in the results obtained. The heterogeneity in the design of the studies made it impossible to generate conclusive results in the application of meta-analysis.</div></div><div><h3>Discussion</h3><div>There is a sex-based differentiation in the behavioral effects associated with bisphenol exposure, as bisphenols affect boys and girls differently, potentially through mechanisms involving estrogen receptors, among other biological pathways.</div></div><div><h3>Conclusions</h3><div>Our study highlights the need to improve and homogenize the design and results of epidemiological studies to extract data effectively. More results are needed to be able to draw conclusions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106274"},"PeriodicalIF":7.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connected brains, connected bodies: A comprehensive model of parent-infant allostatic co-regulation","authors":"Françoise Diaz-Rojas,&nbsp;Michiko Matsunaga,&nbsp;Masako Myowa","doi":"10.1016/j.neubiorev.2025.106277","DOIUrl":"10.1016/j.neubiorev.2025.106277","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106277"},"PeriodicalIF":7.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression diagnosis through emotional induction and physiological signals: A systematic review","authors":"Jing Liu ,&nbsp;Xiangjian He ,&nbsp;Xu Sun ,&nbsp;David Jo","doi":"10.1016/j.neubiorev.2025.106243","DOIUrl":"10.1016/j.neubiorev.2025.106243","url":null,"abstract":"<div><div>Depression is a severe mental disorder that significantly disrupts an individual’s emotional stability and, consequently, their overall quality of life. Traditional diagnostic approaches face limitations, particularly due to subjective biases and resource constraints, prompting increased interest in objective, physiologically-based diagnostic methods. While it is well-established that individuals with depression exhibit marked emotional differences from healthy controls, the specific patterns of emotional responses and physiological signals in response to emotional induction remain insufficiently explored. This review aims to investigate how depressive individuals respond to emotional stimuli, with a particular focus on how these emotional responses can be objectively assessed through physiological signals. A systematic review is conducted by searching PubMed, Web of Science, and Scopus, yielding 1346 results. After applying predefined inclusion criteria, 51 studies are selected for narrative synthesis. The review provides a comprehensive overview of (a) emotion models, (b) emotional stimuli materials and tasks, (c) physiological signals associated with emotional responses, (d) methodologies and devices for measuring these signals, and (e) differences in physiological responses between depressive patients and healthy controls under specific emotional inductions. Furthermore, the review discusses the influence of experimental settings and participant differences on results, as well as considerations regarding the selection, combination, and acquisition of physiological signals. These insights have important implications for advancing both research and clinical auxiliary diagnostic practices for individuals with depression.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106243"},"PeriodicalIF":7.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational cross-species evidence of heart-related dynamics in threat learning","authors":"Simone Battaglia ,&nbsp;Raul Andero ,&nbsp;Julian F. Thayer","doi":"10.1016/j.neubiorev.2025.106273","DOIUrl":"10.1016/j.neubiorev.2025.106273","url":null,"abstract":"<div><div>Fear engenders a vast array of autonomic responses in organisms, which are elicited by the presence of threat. Among these responses, heart rate is influenced by the presence of dangerous events as well but can be modulated based on environmental and internal circumstances. This process, while present across different species, may be subtended by partially different neural mechanisms. Here, we outline a perspective regarding the similarities between human and rodent evidence, which suggests the role of the prefrontal cortex and the insula as central hubs in the modulation of threat responses. However, current disparities between human and animal research preclude drawing definitive parallels, motivating further research with sophisticated neuroimaging and <em>in vivo</em> calcium imaging. Finally, clarifying the cross-species convergence of autonomic regulation may help refine translational models of anxiety and its treatment. Thus, we provide a conceptual framework to bridge cross-species differences and summarize the key brain areas underlying threat-induced autonomic changes, with emphasis on their translational relevance for psychopathology.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106273"},"PeriodicalIF":7.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Psychopathic Brain: Divergent Neuroimaging Findings converge onto a Common Brain Network.","authors":"Jules R Dugré, Stéphane A De Brito","doi":"10.1016/j.neubiorev.2025.106272","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106272","url":null,"abstract":"<p><p>Psychopathy is a personality disorder characterized by a constellation of interpersonal, affective, lifestyle, and antisocial features. Its neural underpinnings remain poorly understood due to the discrepancies in result of functional neuroimaging studies. Here, we tackled this lack of replication by investigating whether heterogeneous peak locations associated with psychopathy could nonetheless map onto a common functional connectivity network. A coordinate-based meta-analysis of 38 functional neuroimaging studies (40 independent samples) on psychopathy revealed only weak spatial convergence across samples. However, using functional connectomes of 1,000 healthy participants, we nonetheless demonstrated that the heterogeneous findings do indeed map onto a common brain network with a replicability reaching up to 87.5% across studies. We subsequently showed strong associations between this Psychopathy Network and a lesion network of 17 lesion sites causally linked to antisocial behaviours, as well as its association with neurotransmission systems and genetic markers previously implicated in the pathophysiology of psychopathy. Taken together, our study highlights the importance of examining the neural correlates of psychopathy from a network perspective, which can be validated using a multilevel approach, encompassing neural, genetic and neurochemical data. Ultimately, this approach may pave the way for novel and more personalised treatments.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106272"},"PeriodicalIF":7.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review","authors":"Shefali Chaudhary ,&nbsp;Herta H. Chao ,&nbsp;Khushbu Agarwal ,&nbsp;Sanjay Gupta ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.neubiorev.2025.106270","DOIUrl":"10.1016/j.neubiorev.2025.106270","url":null,"abstract":"<div><div>Neuroinflammation represents a key pathophysiological process contributing to cognitive decline during aging and may play a significant role in the development of Alzheimer’s disease and related dementia (ADRD). Many magnetic resonance imaging (MRI) studies have investigated the extent and impact of neuroinflammation in older adults and in individuals at various stages of ADRD. These imaging techniques enable the assessment of blood-brain barrier (BBB) permeability, structural damage in white and gray matter, and functional brain impairment. In this review, we summarize the advantages and limitations of various MRI protocols used to study neuroinflammation. With a focus on neuroinflammation, studies that characterized structural and functional brain changes but did not relate the findings to neuroinflammation were outside the scope of this review. However, we provided a brief survey on studies combining multiple imaging modalities for readers to have a broader view on neuroinflammation, aging, and ADRD. We first begin by introducing MRI techniques used to examine BBB dysfunction, neuroinflammation, gray and white matter deficits, and functional brain changes. Next, we reviewed studies investigating neuroinflammation in aging, followed by examination of imaging studies of ADRD in this context. Collectively, these findings indicate that both aging and AD are associated with progressive BBB dysfunction contributing to cognitive decline. Additionally, neural markers derived of diffusion tensor imaging, magnetic transfer imaging, MR spectroscopy, structural imaging, and functional connectivity provide valuable insights into neuroinflammatory processes. This body of research highlights MRI’s potential as a non-invasive tool for monitoring neuroinflammation and tracking disease onset and progression.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106270"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cannabis use and paranoia: Meta-analysis of experimental and observational studies","authors":"Martino Belvederi Murri ,&nbsp;Salvatore Catania ,&nbsp;Sara Centra ,&nbsp;Federica Folesani ,&nbsp;Angela Muscettola ,&nbsp;Luigi Zerbinati ,&nbsp;Tommaso Toffanin ,&nbsp;Maria Ferrara ,&nbsp;Paolo Ossola ,&nbsp;Rodolfo Rossi ,&nbsp;Tommaso Jannini ,&nbsp;Rosangela Caruso ,&nbsp;Maria Giulia Nanni ,&nbsp;Luigi Grassi","doi":"10.1016/j.neubiorev.2025.106269","DOIUrl":"10.1016/j.neubiorev.2025.106269","url":null,"abstract":"<div><div>Paranoia is common and has negative implications at clinical and societal levels. Cannabis may cause paranoia, although conflicting evidence exists. We reviewed studies on the association between cannabinoid use and paranoid symptoms. PubMed was searched from inception to July 2023, seeking experimental and observational studies that measured paranoid symptoms with specific assessments. Data of 13 studies (n = 13.559 participants) were pooled using Bayesian Model-Averaged Meta-Analysis, hierarchical Bayesian meta-analyses and Robust Bayesian Meta-Analysis. Effect size measures were Standardized Mean Difference (SMD) or Odds Ratio (OR). Five experimental studies showed that participants receiving cannabinoids developed more severe paranoid symptoms than those receiving placebo (SMD = 0.47; 95 % CI, 0.13 – 0.48, Posterior Probability of Inclusion, PPI: 94 %). Studies using TCH-prevalent cannabinoids detected higher effects than those administering mixed THC-CBD or CBD- prevalent cannabinoids. In four cross-sectional studies from the general population, the odds of displaying paranoid symptoms in cannabinoid users was higher than in non-users (OR: 1.75, 95 % CI, 1.43–2.07, PPI: 99 %), with effects increasing with the percentage of males in the sample. The pooled effect was not significant in studies recruiting patients with psychiatric disorders. Results of three prospective studies also suggest that cannabis is associated with the subsequent onset of paranoid symptoms. In conclusion, converging evidence from experimental and observational studies suggest that cannabinoids are associated with, and may cause paranoid symptoms. Preventive and therapeutical actions may be warranted, considering the implications of paranoia, and the dramatic increase in cannabis use worldwide.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106269"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative perspectives on mother-infant communication in primates: Are humans unique?","authors":"Federica Amici ,&nbsp;Katja Liebal","doi":"10.1016/j.neubiorev.2025.106271","DOIUrl":"10.1016/j.neubiorev.2025.106271","url":null,"abstract":"<div><div>Human cognition is often claimed to be unique within the animal kingdom. Comparing infant development across primate species to examine maternal interactions is a promising approach to understanding potential cognitive differences between humans and other primates. In this review, we focus on the communicative interactions between mother-infant dyads in nonhuman primate species and humans from different cultural backgrounds, as these interactions are crucial for infant survival, the formation of emotional bonds, and cognitive development. We explore different aspects of mother-infant communication, including the dynamics of these interactions, intra-species variation in mother-infant communication across groups and individuals, and the potential role of other caregivers. Additionally, we address current methodological challenges, such as the underrepresentation of multimodal approaches in studying mother-infant communication and the need for standardized methods to facilitate systematic comparisons across species and study populations. We conclude that it is currently premature to answer the question if human mother-infant communicative interactions are fundamentally different as compared to those of other primates, as critical knowledge gaps must be filled first. We address some of these gaps and propose key aspects that need to be examined to develop a more comprehensive understanding of mother-infant communication across primates and its potential influence on infants’ developmental trajectories.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106271"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac vagal recovery following acute psychological stress in human adults: A scoping review.","authors":"Charlotte M Roddick, Yeon Soo Christine Seo, Shan-Li Barkovich, Luke Forrester, Frances S Chen","doi":"10.1016/j.neubiorev.2025.106268","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106268","url":null,"abstract":"<p><p>Vagally mediated heart rate variability (vmHRV) recovery following acute psychological stress reflects parasympathetic function and stress resilience, yet there is no synthesis on how it is measured and influenced by key factors. This scoping review mapped methodologies used to assess vmHRV recovery and examined clinical, demographic, psychological, physiological and environmental influences. Following PRISMA-ScR guidelines, a comprehensive search of MEDLINE, PsycINFO, and EMBASE databases identified empirical peer-reviewed studies on cardiac vagal recovery in adults published since 2000 that reported vmHRV post-stress. Key data, including recovery operationalization, stressor types, and factors influencing recovery, were extracted and synthesized. A total of 291 journal articles, covering 294 studies (N = 23,533 participants across 33 countries; 56.1% female), met inclusion criteria. Evidence indicated that enhanced vmHRV recovery was associated with greater levels of resilience, attentional control, habitual use of cognitive reappraisal, and exposure to nature elements. In contrast, blunted vmHRV recovery was linked with clinical depression, cardiovascular disease risk, and emotion dysregulation. Methodological challenges included variability in recovery timing (e.g., 5- vs. 30-minute windows) and inconsistent reporting of recovery conditions (e.g., posture). Aggregation of recovery data across dissimilar stressors without justification also contributed to interpretation issues. This review highlights substantial variability in how vmHRV recovery is measured and reported, limiting comparability across studies. Core recommendations include justifying recovery timing, standardizing recovery conditions, and prioritizing non-normalized vmHRV metrics to improve consistency. These methodological improvements will enhance cross-study comparisons, facilitate meta-analyses, and advance understanding of the role of cardiac vagal recovery in stress resilience and health outcomes.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106268"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: A look back into the past can improve our understanding of the present and the future of medicine and the neurosciences","authors":"Martin Brüne ,&nbsp;Dan J. Stein","doi":"10.1016/j.neubiorev.2025.106267","DOIUrl":"10.1016/j.neubiorev.2025.106267","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106267"},"PeriodicalIF":7.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}