Neuroscience and Biobehavioral Reviews最新文献

{"title":"Diffusion MRI of gray matter microstructural profiles in healthy aging.","authors":"Jenna L Merenstein","doi":"10.1016/j.neubiorev.2026.106896","DOIUrl":"10.1016/j.neubiorev.2026.106896","url":null,"abstract":"<p><p>Diffusion-weighted imaging (DWI) is a non-invasive magnetic resonance imaging (MRI) acquisition technique that can provide detailed information about brain microstructure. This methodology has historically been applied only to white matter tissue in the research context, but more recent literature suggests that diffusion MRI can also be applied to study microstructural alterations of gray matter tissue, including in healthy aging. The current narrative review evaluates diffusion MRI studies investigating age-related differences in gray matter microstructure and their implications for understanding cognitive function in healthy older adults. The studies reviewed here report widespread age-related differences in cortical (especially frontoparietal), hippocampal, and subcortical microstructure that is behaviorally relevant- especially for cognitive domains of learning and memory. Gray matter microstructure is consistently influenced by the presence of dementia-related pathology, physical activity, and sleep health, but additional research work is needed to understand the roles of biological sex, environment, and dietary intake. Future work of gray matter microstructural profiles in healthy aging should consider longitudinal designs, combining different diffusion MRI modeling techniques in the same study, and defining more specific cognitive correlates (e.g., processing speed).</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"189 ","pages":"106896"},"PeriodicalIF":8.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criminal legal system contact and markers of biological aging: A systematic review.","authors":"Mariana Rodrigues, Adolfo G Cuevas, Alisha A Crump, Zoe Lindenfeld, Saba Rouhani, Jemar R Bather","doi":"10.1016/j.neubiorev.2026.106942","DOIUrl":"10.1016/j.neubiorev.2026.106942","url":null,"abstract":"<p><strong>Background: </strong>Contact with the criminal legal system (CLS) is a prevalent and socially patterned exposure in the United States with well-documented health consequences. Growing research suggests that CLS contact may be associated with biological aging, but evidence remains variable across biomarker domains, forms of exposure, and study designs. This systematic review synthesized literature on CLS contact and biomarkers relevant to biological aging in the U.S.</p><p><strong>Methods: </strong>We systematically searched seven electronic databases and Google Scholar. Eligible studies examined direct or vicarious CLS contact in relation to at least one biomarker domain relevant to biological aging, including epigenetic measures, telomere length, inflammatory markers, or allostatic load. Retrieved references were imported into Covidence for deduplication and screening. Data were extracted using a standardized form and evidence quality was assessed using an adapted Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Twenty-two studies met inclusion criteria. Sixteen studies (72.7%) reported findings consistent with accelerated biological aging in association with CLS contact. The most consistent evidence was observed for epigenetic outcomes, with all seven studies reporting significant accelerated epigenetic aging in association with CLS contact. Evidence for inflammatory markers, allostatic load, and telomere length was less consistent, although several studies linked CLS contact with elevated inflammation, greater multisystem physiological dysregulation, and shorter telomere length. Associations varied by form of CLS contact, timing, and context, including violence during incarceration and racialized exposure to policing.</p><p><strong>Conclusions: </strong>CLS contact may be associated with multiple biological systems relevant to biological aging. More research is needed to clarify temporality, heterogeneity, and underlying pathways.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106942"},"PeriodicalIF":8.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics' response and resistance: A systematic review and critical appraisal.","authors":"Mariateresa Ciccarelli, Benedetta Mazza, Anita Nasti, Federica Iannotta, Claudio Caiazza, Marta Matrone, Valeria Gaudieri, Giuseppe De Simone, Licia Vellucci, Michele Fornaro, Felice Iasevoli, Annarita Barone, Andrea de Bartolomeis","doi":"10.1016/j.neubiorev.2026.106938","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106938","url":null,"abstract":"<p><strong>Background: </strong>The Fusiform Gyrus (FG), a brain region relevant for the interaction between cognitive processes and emotional behavior, especially emotion recognition and interpretation of social cues, has been linked to the pathophysiology of schizophrenia conceptualized as a disorder of aberrant synaptic function and brain connectivity as well as characterized by disruptions in thought processes, perceptions, emotional responsiveness, and Theory of Mind (ToM). Disrupted FG connectivity has been reported in schizophrenia; however, no systematic review has addressed this issue in a comprehensive and critical manner.</p><p><strong>Methods: </strong>We conducted a systematic review of PubMed, Embase, and Scopus from database inception to February 2026 following PRISMA guidelines. We included peer-reviewed neuroimaging studies using functional magnetic resonance imaging to assess functional connectivity or task-related activation of the FG in patients with schizophrenia compared with healthy controls.</p><p><strong>Results: </strong>We identified 2765 articles from different sources. After duplicate removal, 959 articles were screened at the title-abstract level, 269 articles were reviewed for full-texts, and 86 eligible articles were included. Across fMRI studies, the FG emerged as a central node of dysconnectivity. Drug-naïve patients showed heterogeneous FG alterations, with increased local activity and network centrality reported in some studies and reduced interhemispheric and functional connectivity in others, alongside reduced FG activation on visual, affective, and sensory tasks reported more broadly across schizophrenia samples. First-episode psychosis patients were characterized by FG hypoconnectivity associated with negative symptoms and socio-cognitive impairment. Treatment-responsive patients demonstrated partial normalization or modulation of fusiform connectivity and network centrality following antipsychotic treatment. In contrast, treatment-resistant schizophrenia patients showed persistent hypoactivation and reduced connectivity, correlating with cognitive deficits and negative symptoms.</p><p><strong>Conclusions: </strong>The FG appears to function as a dynamic, state-sensitive hub underlying perceptual, emotional, and cognitive disturbances in schizophrenia, in line with impaired ToM.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"191 ","pages":"106938"},"PeriodicalIF":8.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise first: acute aerobic exercise before practice selectively enhances spatial outcomes of motor learning - A Systematic Review and Meta-Analysis.","authors":"Nesrine Harroum, Amanda O'Farrell, Layale Youssef","doi":"10.1016/j.neubiorev.2026.106936","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106936","url":null,"abstract":"<p><p>(235 words) Acute aerobic exercise (AAE) has been shown to influence motor learning outcomes, but previous studies have typically focused on overall performance measures, leaving it unclear whether spatial and temporal components are differentially affected. In addition, the impact of exercise timing and intensity on these effects has not yet been investigated. This pre-registered meta-analysis aimed to evaluate these effects. A systematic search of four databases (Web of Science, ERIC, MEDLINE, SPORTDiscus) identified 18 studies including 657 participants. Spatial and temporal outcomes of motor learning were analyzed separately, considering whether AAE was performed before or after motor task practice. A random-effects meta-analysis was performed, with Hedges' g as the effect size. Overall, our findings demonstrated that AAE performed before motor task practice selectively enhanced spatial outcomes of motor learning (g = 0.30, 95%CI [0.14; 0.47], p = 0.0003), whereas temporal components showed no significant change (g = 0.01, 95%CI [-0.15; 0.17], p = 0.911). A meta-regression indicated that high AAE intensity significantly moderated this effect (g = 0.48, 95% CI [0.28; 0.69], p < 0.001). These findings indicate that spatial and temporal components of motor learning are differentially sensitive to AAE, with spatial outcomes preferentially enhanced by AAE performed before motor task practice and at high AAE intensities. This distinction has important implications for sports training and clinical rehabilitation, suggesting that interventions can be tailored to prioritize spatial precision over temporal aspects, thereby enhancing specific motor learning outcomes.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106936"},"PeriodicalIF":8.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum \"Feeling in control when things go well: A meta-analytical account of how action-outcome valence shapes the implicit sense of agency\" Neurosci. Biobehav. Rev., 179 (2025) 106443.","authors":"Marika Mariano, Francantonio Devoto, Laura Zapparoli","doi":"10.1016/j.neubiorev.2026.106917","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106917","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106917"},"PeriodicalIF":8.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions in speech, language and social communication in lysosomal storage diseases.","authors":"Georgina Johnson, Raquel van Gool, Karlton Gaskin, Jen Wong, Jaymin Upadhyay, Adam P Vogel","doi":"10.1016/j.neubiorev.2026.106931","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106931","url":null,"abstract":"<p><p>Communication enables social connection, autonomy and identity, making it a fundamental domain of human functioning. In lysosomal storage diseases (LSDs), progressive neurological dysfunction can severely disrupt speech, language and social communication, resulting in profound isolation and reduced quality of life. LSDs are a heterogeneous group of more than 70 inherited metabolic disorders caused by lysosomal dysfunction and substrate accumulation, leading to severe neurological consequences and multisystem pathology. LSDs are classified according to the biochemical nature of the accumulating substrate, reflecting both the underlying enzymatic defect and clinical phenotype. Disease groups include sphingolipidoses (e.g., Gaucher disease), mucopolysaccharidoses (e.g., Hurler syndrome [MPS I]), glycoproteinoses (e.g., aspartylglycosaminuria), gangliosidoses (e.g., Tay-Sachs disease), neuronal ceroid lipofuscinoses (e.g., Batten Disease [CLN3]) and other lipid storage disorders such as Pompe disease or Niemann Pick Type C. Clinical presentations are highly variable, with neurodevelopmental symptoms presenting in infancy or early childhood for many. In this review, we synthesize evidence on speech, language, and social communication phenotypes across lysosomal storage diseases, examining how they can mirror underlying neurodegenerative processes and provide insight into disease progression and neurological vulnerability. We discuss the potential of communication phenotyping to improve diagnosis and prognostic stratification, inform therapeutic monitoring, and guide timely, targeted interventions to preserve social connection and quality of life.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"190 ","pages":"106931"},"PeriodicalIF":8.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The two-body problem in interpersonal distance: A process model of social space regulation in psychopathology.","authors":"Arvid Herwig","doi":"10.1016/j.neubiorev.2026.106941","DOIUrl":"10.1016/j.neubiorev.2026.106941","url":null,"abstract":"<p><p>Interpersonal distance (IPD), the physical proximity individuals maintain during face-to-face interaction, is disrupted across a range of disorders involving distorted or threat-biased body representation, from eating disorders to social anxiety and schizophrenia. The dominant mechanistic account links this disruption to peripersonal space (PPS), modeling IPD as the output of the perceiver's own defensive boundary. This account is egocentric: it treats the approaching person as a source of threat rather than as a body whose size, kinematics, and spatial requirements must themselves be represented. IPD regulation, however, is a two-body problem that no current single-body model addresses. Drawing on recent evidence that the spatial properties of another person's body enter the same sensorimotor system that codes one's own PPS, the present article extends the body-representation framework of Möllmann et al., (2024) into a process model of IPD regulation. The model specifies how self-body and other-body representations are coupled across action-guiding, metric, and evaluative stages within a continuous control loop, and proposes how this coupling could render otherwise contradictory findings (most notably the inconsistent IPD effects in anorexia nervosa) more tractable. I further argue that markerless multi-person motion capture is a suitable platform for measuring this process, and outline a research agenda that moves beyond static stop distances toward the approach-avoidance kinematics through which body-representation-based IPD dysregulation is most directly expressed.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106941"},"PeriodicalIF":8.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the functional neurocognitive correlates of loss aversion: A coordinate-based meta-analysis.","authors":"Maria Arioli, Michele Pietro Maria Colletti, Zaira Cattaneo, Nicola Canessa","doi":"10.1016/j.neubiorev.2026.106937","DOIUrl":"10.1016/j.neubiorev.2026.106937","url":null,"abstract":"<p><p>We performed the first coordinate-based meta-analysis of functional neuroimaging studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) to investigate the neural correlates of loss aversion, defined as the tendency to overweight potential losses relative to equivalent gains in decision-making under risk. We aimed both to identify its core functional neurocognitive correlates, and to characterize the roles of the identified regions across behavioral domains. Among the studies reporting λ, mean estimates ranged from 1.12 to 2.20 (overall mean = 1.71), confirming the typical overweighting of losses relative to equivalent gains. Meta-analytic findings revealed the consistent involvement of the striatum, anterior insula and dorsal anterior/middle cingulate cortex (dACC/MCC). We complemented these findings with a functional characterization of these regions in terms of their associated behavioral domains, including reward processing, emotion, interoception, pain and higher-order reasoning. This characterization supports a model in which loss aversion reflects the integration of affective and cognitive mechanisms. By contrast, we found no consistent meta-analytic evidence for amygdala involvement in loss aversion. This negative finding likely reflects both methodological constraints inherent in coordinate-based meta-analyses, including the selective inclusion of whole-brain results, and the sensitivity of amygdala responses to task and/or stimulus characteristics. In addition to providing a foundational framework for understanding the neural correlates of human choice and loss aversion, these findings offer a benchmark for investigating clinical conditions characterized by altered evaluative processes and for assessing the effects of therapeutic interventions.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106937"},"PeriodicalIF":8.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From metabolism to reproduction: The emerging roles of adipokines in neuroendocrine regulation, gonadal function, and sexual behavior.","authors":"Karina Hernández-Ortega, Claudia Bello-Alvarez, Raymundo Domínguez-Ordoñez, Marcos Garcia-Juaréz, Oscar González-Flores, Ignacio Camacho-Arroyo","doi":"10.1016/j.neubiorev.2026.106940","DOIUrl":"10.1016/j.neubiorev.2026.106940","url":null,"abstract":"<p><p>Adipokines are proteins synthesized and secreted by several tissues, predominantly adipose tissue, which regulate multiple physiological functions. Historically, they have been mainly associated with regulating energy homeostasis, including glucose metabolism and body weight control. However, accumulating evidence over the past decade indicates that their actions extend far beyond metabolic processes. Adipokines are now recognized as pleiotropic hormonal mediators exerting systemic effects on various organs, including the central nervous system, where they modulate neuroendocrine circuits essential for complex physiological functions. Understanding the mechanisms that regulate reproductive function is crucial for elucidating reproductive physiology and improving fertility-related clinical outcomes. In this review, we focus on an underexplored aspect of adipokines' function: their role as modulators of reproduction and sexual behavior. Recent data demonstrate that several adipokines, including leptin and apelin-13, modulate hypothalamic-pituitary-gonadal axis function and neural circuits involved in reproductive physiology and sexual behavior. Peripheral reproductive actions, including effects on steroidogenesis and gametogenesis, are discussed as complementary mechanisms that interact with central neuroendocrine regulation. Furthermore, dysregulation of adipokine signaling pathways has been linked to various reproductive disorders and fertility impairments in both males and females. These findings underscore the importance of considering adipokines within the broader context of reproductive physiology.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106940"},"PeriodicalIF":8.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does HIV-1 infection drive Alzheimer's disease pathobiology?","authors":"Elizabeth O Etafo, Debashis Dutta, Shaurav Bhattarai, Howard E Gendelman, Santhi Gorantla","doi":"10.1016/j.neubiorev.2026.106932","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106932","url":null,"abstract":"<p><p>Lifelong antiretroviral therapy extends the lifespan of individuals with human immunodeficiency virus (HIV). However, HIV-associated neurocognitive disorders (HAND) remain with age-linked comorbidities. Despite viral suppression, the co-development of Alzheimer's disease (AD) remains a concern. Both HAND and AD share key mechanisms, including chronic neuroinflammation, glial dysfunction, and progressive neurodegeneration. Microglial activation is a key contributor that generates persistent proinflammatory neurotoxins, promoting amyloid-β aggregation, disrupting clearance, and accelerating neurodegeneration. Persistent viral reservoirs and low-level viral protein expression disrupt glial homeostasis, enhancing oxidative stress, tau hyperphosphorylation, and synaptic damage in the brain. This review highlights the intersections between both disorders and discusses emerging rodent models to investigate convergent pathways with the goal of improving therapeutic strategies to preserve cognitive health.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"190 ","pages":"106932"},"PeriodicalIF":8.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}