Neuroscience and Biobehavioral Reviews最新文献

{"title":"The overlooked role of metabolic disorders in bipolar disorder","authors":"Anouar Khayachi , Abraham Nunes , Martin Alda , Guy A. Rouleau","doi":"10.1016/j.neubiorev.2025.106203","DOIUrl":"10.1016/j.neubiorev.2025.106203","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106203"},"PeriodicalIF":7.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From data to discovery: Technology propels speech-language research and theory-building in developmental science","authors":"Zuzanna Laudańska ,&nbsp;Anna Caunt ,&nbsp;Alejandrina Cristia ,&nbsp;Anne Warlaumont ,&nbsp;Katerina Patsis ,&nbsp;Przemysław Tomalski ,&nbsp;Petra Warreyn ,&nbsp;Drew H. Abney ,&nbsp;Jeremy I. Borjon ,&nbsp;Manu Airaksinen ,&nbsp;Emily JH Jones ,&nbsp;Sven Bölte ,&nbsp;Magdalena Dall ,&nbsp;Daniel Holzinger ,&nbsp;Luise Poustka ,&nbsp;Herbert Roeyers ,&nbsp;Sam Wass ,&nbsp;Dajie Zhang ,&nbsp;Peter B. Marschik","doi":"10.1016/j.neubiorev.2025.106199","DOIUrl":"10.1016/j.neubiorev.2025.106199","url":null,"abstract":"<div><div>Research on speech and language development has a long history, but in the past decade, it has been transformed by advances in recording technologies, analysis and classification tools, and AI-based language models. We conducted a systematic literature review to identify recently developed (semi-)automatic tools for studying speech-language development and learners' environments in infants and children under the age of 5 years. The Language ENvironment Analysis (LENA) system has been the most widely used tool, with more and more alternative free- and/or open-source tools emerging more recently. Most studies were conducted in naturalistic settings, mostly recording longer time periods (daylong recordings). In the context of vulnerable and clinical populations, most research so far has focused on children with hearing loss or autism. Our review revealed notable gaps in the literature regarding cultural, linguistic, geographic, clinical, and social diversity. Additionally, we identified limitations in current technology—particularly on the software side—that restrict researchers from fully leveraging real-world audio data. Achieving global applicability and accessibility in daylong recordings will require a comprehensive approach that combines technological innovation, methodological rigour, and ethical responsibility. Enhancing inclusivity in participant samples, simplifying tool access, addressing data privacy, and broadening clinical applications can pave the way for a more complete and equitable understanding of early speech and language development. Automatic tools that offer greater efficiency and lower cost have the potential to make science in this research area more geographically and culturally diverse, leading to more representative theories about language development.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106199"},"PeriodicalIF":7.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents","authors":"Chad A. Brunswick ,&nbsp;Catherine M. Carpenter ,&nbsp;Nancy A. Dennis ,&nbsp;Janine L. Kwapis","doi":"10.1016/j.neubiorev.2025.106195","DOIUrl":"10.1016/j.neubiorev.2025.106195","url":null,"abstract":"<div><div>Memory is a reconstructive and continuous process that enables existing information to be modified in response to a changing environment. Being able to dynamically update outdated memories is critical to an organism’s survival. Memory modifications have been extensively studied in both rodents and humans, and prior work has revealed many regional, cellular, neurotransmitter, and subcellular molecular mechanisms underlying this process. However, these diverse bodies of literature have not yet been fully integrated into a comprehensive cross-species review. Integrating the finding across rodent and human work is important for furthering our understanding of memory modifications and the underlying neural mechanisms that support memory modification in both species. Here, we discuss advances in our understanding of adaptive and maladaptive memory modifications in terms of both underlying mechanisms (regional, cellular, and molecular) and behavioral outcomes. By emphasizing findings from both humans and rodents, the two major model systems in which memory modifications have been studied, we are able to highlight converging mechanisms and point to open questions in the field. Specifically, we discuss the major findings from several memory paradigms including declarative, aversive and procedural memory designs and highlight paradigms and models that have been readily translated between rodent and human models. Ultimately, this review identifies key parallels underlying memory updating across species, paradigms, tasks, and models.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106195"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-intervention neuroimaging effects of psychosocial interventions aimed at promoting resilience in children and adolescents under psychological stress: A systematic review","authors":"Nitish Jawahar ,&nbsp;Bavesh Jawahar ,&nbsp;Kapil Sayal ,&nbsp;Dorothee P. Auer","doi":"10.1016/j.neubiorev.2025.106196","DOIUrl":"10.1016/j.neubiorev.2025.106196","url":null,"abstract":"<div><div>Childhood and adolescence are neurodevelopmentally critical periods, during which psychological adversity can increase the risk of subsequent mental health difficulties. However, the increased neuroplasticity during this window also confers potential for developing resilience, which is now seen as a dynamic process of adapting to adversity. This pre-registered systematic review (PROSPERO-CRD42024537715) summarises the post-intervention neuroimaging outcomes of non-invasive, non-pharmacological interventions aimed at promoting resilience in samples with a mean age of &lt; 25 years exposed to any explicit psychological stress. Studies involving traumatic or focal brain lesions were excluded. MEDLINE, PsycINFO and CENTRAL databases were searched from inception to 14/7/2024. Magnetic Resonance Imaging (MRI) outcomes were the primary focus. Risk of bias was assessed against adapted Joanna Briggs Institute checklist items. A narrative synthesis was conducted due to study heterogeneity. We identified 13 eligible studies: 1 reporting structural and diffusion-weighted MRI (performed after 2 years of intervention), 1 resting-state fMRI (14 years after end of intervention) and 11 task-based fMRI metrics (ranging from immediately post-intervention to 8 years after end of intervention). Resilience interventions reduce limbic activity (thalamus, amygdala and right anterior insula) in task-based fMRI. In older adolescents, social, mindfulness, and exercise interventions strengthen Prefrontal Cortex(PFC)-limbic connectivity, decreasing limbic activity. Evidence in younger adolescents is sparse, showing mixed effects on PFC-limbic connectivity. Five studies were at high risk of bias; the most common limitation was no pre-intervention MRI scans. Overall, this study summarises promising mechanisms, as demonstrated on neuroimaging, through which resilience can be enhanced in stressed youth through psychosocial interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106196"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cerebellum in frontotemporal dementia: From neglected bystander to potential neuromodulatory target. A narrative review","authors":"Annibale Antonioni ,&nbsp;Emanuela Maria Raho ,&nbsp;Danny Adrian Spampinato ,&nbsp;Enrico Granieri ,&nbsp;Luciano Fadiga ,&nbsp;Francesco Di Lorenzo ,&nbsp;Giacomo Koch","doi":"10.1016/j.neubiorev.2025.106194","DOIUrl":"10.1016/j.neubiorev.2025.106194","url":null,"abstract":"<div><h3>Background</h3><div>Though cortical changes in frontotemporal dementia (FTD) are well-documented, the cerebellum's role, closely linked to these areas, remains unclear.</div></div><div><h3>Objectives</h3><div>To provide evidence on cerebellar involvement in FTD across clinical, genetic, imaging, neuropathological, and neurophysiological perspectives. Additionally, we sought evidence supporting the application of cerebellar non-invasive brain stimulation (NIBS) in FTD for both diagnostic and therapeutic purposes.</div></div><div><h3>Methods</h3><div>We performed a literature review using MEDLINE (via PubMed), Scopus, and Web of Science databases.</div></div><div><h3>Results</h3><div>We emphasized the involvement of specific cerebellar regions which differentiate each FTD subtypes and may account for some of the characteristic symptoms. Furthermore, we highlighted peculiarities in FTD genetic alterations. Finally, we outlined neurophysiological evidence supporting a role for the cerebellum in FTD pathogenesis.</div></div><div><h3>Conclusion</h3><div>The cerebellum is critically involved in the FTD spectrum. Moreover, it can be speculated that cerebellar modulation, as already shown in other neurodegenerative disorders, could restore the interneuronal intracortical circuits typically impaired in FTD patients, providing clinical improvements and fundamental outcome measures in clinical trials.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106194"},"PeriodicalIF":7.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala hyperactivation in childhood maltreatment: An ALE-based meta-analysis on emotion-related processing","authors":"Pei-Chi Kuo ,&nbsp;Zai-Fu Yao","doi":"10.1016/j.neubiorev.2025.106180","DOIUrl":"10.1016/j.neubiorev.2025.106180","url":null,"abstract":"<div><div>Childhood maltreatment (CM), encompassing various forms of abuse and neglect, is associated with adverse developmental outcomes and heightened risk for psychiatric conditions. Functional magnetic resonance imaging (fMRI) studies point to altered neural responses during tasks involving emotion-related processing in maltreated individuals, yet inconsistent findings have limited the field’s ability to draw clear conclusions about the loci of altered brain function. This meta-analysis aimed to synthesize existing task-based fMRI data on emotional processing in individuals with a history of childhood maltreatment, with particular emphasis on identifying consistent patterns of hyperactivation compared to non-maltreated controls. A systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines across Web of Science, Scopus, PubMed, and PsycInfo identified 674 studies, of which 30 met the inclusion criteria. Using the Activation Likelihood Estimation (ALE) method, the meta-analysis incorporated 368 brain coordinates (foci) and 93 contrasts from experiments involving 2474 participants (1169 in the maltreatment group and 1305 in the control group). The ALE analysis identified a robust cluster of hyperactivation in the right amygdala in maltreated individuals during emotional processing tasks. Peak activation was observed at [20, –4, –16], suggesting heightened threat detection and emotional reactivity in those with a history of childhood maltreatment. No significant clusters emerged for increased activation in the control group. These findings underscore the amygdala's central role as a neural substrate affected by childhood maltreatment, contributing to heightened emotional reactivity and dysregulated emotion-related processing in affected individuals.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106180"},"PeriodicalIF":7.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expanding spectrum of infectious risk organisms and immunogenetic susceptibility in neuropsychiatric disorders","authors":"Monojit Debnath","doi":"10.1016/j.neubiorev.2025.106177","DOIUrl":"10.1016/j.neubiorev.2025.106177","url":null,"abstract":"<div><div>The spectrum of infectious risk organisms showing associations with psychiatric traits is expanding. Infectious agents can modulate the risk of psychiatric disorders at different stages of life, such as gestational, childhood, adolescent, and adult periods. Prenatal infection appears to ‘prime’ the developing brain, whereas infection during childhood or later periods may act as a ‘second hit’, and these may have synergistic effects on the risk of developing psychiatric diseases. However, neither all the individuals with antecedent infection develop psychiatric disorders, nor do infectious organisms alone lead to psychiatric phenotypes. This suggests modulatory effects of additional host factors. The host genetic background crucially determines differential susceptibility to infection and serves as an important gateway for immune activation and signalling, as well as homeostatic brain functions. Despite the presence of several immune checkpoints and effectors, the infectious organisms disrupt the balance between immune-activating and immune-compensatory mechanisms and contribute to immune dysregulation. This depends substantially on genetic loci encoding immune molecules such as Toll-like receptors, Major Histocompatibility Complex, cytokines/ chemokines and their receptors, complement proteins, and other molecules and elements such as human endogenous retroviruses and gut microbiome that have distinct roles in immune regulation and immune effector functions. Genetic variations within these loci not only influence differential susceptibility to infection but also confer risk to psychiatric disorders. This article highlights a comprehensive overview of the nexus between infections and immune function-related genes and their impact on psychiatric traits. Understanding such interactions will lead to the identification of genetic markers of susceptibility to infection and psychiatric diseases.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106177"},"PeriodicalIF":7.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of childhood adversity: Two specific neural patterns","authors":"Linlin Yan ,&nbsp;Eline J. Kraaijenvanger ,&nbsp;Ricardo Wennekers ,&nbsp;Veronika I. Müller ,&nbsp;Simon B. Eickhoff ,&nbsp;Guillén Fernández ,&nbsp;Nathalie E. Holz ,&nbsp;Nils Kohn","doi":"10.1016/j.neubiorev.2025.106176","DOIUrl":"10.1016/j.neubiorev.2025.106176","url":null,"abstract":"<div><div>Childhood adversity (CA) is associated with an elevated risk of psychopathology across the lifespan and altered brain functions are thought to play an important role in linking CA to mental vulnerability. Previous research has proposed that CA generally influences emotion processing and particularly affects reward processing and cognitive control, yet convergent evidence for CA-related neural and functional networks underlying these processes remains to be fully understood. To investigate the impact of CA on functional brain activations, the present study performed Activation Likelihood Estimation (ALE) analyses across neuroimaging studies involving three task domains: emotion processing, cognitive control, and reward processing. ALE results revealed two significant CA-related convergences of activation in the left amygdala and insula. To better understand and characterize the functions of these ALE-derived clusters, we applied the Meta-Analytic Connectivity Modeling (MACM) approach to identify co-activation maps, and the functional decoding approach to reveal cluster-related psychological processes. Results demonstrated two distinct neural and functional networks in CA: an amygdala-centered emotion processing network and an insula-centered somatomotor processing network. These specific neural patterns indicate the effect of CA on multiple neural and functional networks engaged in sensory-motor and emotion processing functions. Our results provide insights into the neurobiological embedding associated with CA.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106176"},"PeriodicalIF":7.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity of the striatum in psychosis: Meta-analysis of functional magnetic resonance imaging studies and replication on an independent sample","authors":"David Antonio Grimaldi ,&nbsp;Angelo Patane’ ,&nbsp;Giulia Cattarinussi ,&nbsp;Fabio Sambataro","doi":"10.1016/j.neubiorev.2025.106179","DOIUrl":"10.1016/j.neubiorev.2025.106179","url":null,"abstract":"<div><div>Neuroimaging studies have shown that striatal functional connectivity (FC) is altered in psychosis (PSY). However, the evidence remains heterogeneous, partly due to the different subregions and clinical stages considered. For this reason, we gathered available studies that evaluated FC between the striatum and the whole brain in PSY through systematic research of the literature. Then, we performed a coordinate-based activation meta-analysis of brain regions that showed dysconnectivity with the striatum to identify spatially convergent patterns (40 experiments, 4473 subjects). The analysis was replicated for the experiments including only individuals with schizophrenia, first-episode psychosis (FEP), and drug-naïve FEP, and assessing the FC of the limbic and associative striatum. Lastly, we analyzed an independent sample to assess the relationship between these changes and clinical and cognitive variables. In PSY, the striatum was hypoconnected with the anterior cingulate cortex/medial prefrontal cortex (replicated in all analyses and in the independent sample, where the FC was correlated with cognitive flexibility), and with the right thalamus, while it was hyperconnected with the right caudate and the left middle frontal gyrus. These findings of specific patterns of striatal dysconnectivity in PSY could improve our understanding of the role of the striatum in pathophysiology and provide potential biomarkers and targets for new treatments.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106179"},"PeriodicalIF":7.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The whole-brain structural and functional connectome in Alzheimer’s disease spectrum: A multimodal Bayesian meta-analysis of graph theoretical characteristics","authors":"Wenxiong Liu ,&nbsp;Chao Zuo ,&nbsp;Li Chen ,&nbsp;Huan Lan ,&nbsp;Chunyan Luo ,&nbsp;Xiao Li ,&nbsp;Graham J. Kemp ,&nbsp;Su Lui ,&nbsp;Xueling Suo ,&nbsp;Qiyong Gong","doi":"10.1016/j.neubiorev.2025.106174","DOIUrl":"10.1016/j.neubiorev.2025.106174","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) spectrum is increasingly recognized as a progressive network-disconnection syndrome. Neuroimaging studies using graph theoretical analysis (GTA) have reported alterations in the topological properties of whole-brain structural and functional connectomes in both preclinical AD and AD patients, though findings remain inconsistent. This study aimed to identify robust changes in multimodal GTA metrics across the AD spectrum through a comprehensive literature search and Bayesian random-effects meta-analyses. The analysis included 53 studies (37 functional and 17 structural), involving 1649 AD patients, 1455 preclinical AD patients, and 1771 healthy controls (HC). Results revealed lower structural network integration (evidenced by higher characteristic path length and/or normalized characteristic path length) and segregation (evidenced by lower clustering coefficient and local efficiency) in AD and preclinical AD patients compared to HC. Functional network segregation was also lower in AD patients, while preclinical AD showed preserved functional topology despite structural changes. Moderator analyses identified potential methodological moderators, including neuroimaging technique, node and edge definitions, and network type, although further validation is needed. These findings support the progressive disconnection hypothesis in the AD spectrum and suggest that structural network alterations may precede functional network changes. Furthermore, the results help clarify inconsistencies in previous studies and highlight the utility of graph-based metrics as biomarkers for staging AD progression.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"174 ","pages":"Article 106174"},"PeriodicalIF":7.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}