Neuroscience and Biobehavioral Reviews最新文献

{"title":"Corrigendum to \"Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis\" Neurosci. Biobehav. Rev. 161 (2024) 105690.","authors":"Jessica Ahrens, Farida Zaher, Rachel A Rabin, Clifford M Cassidy, Lena Palaniyappan","doi":"10.1016/j.neubiorev.2025.106102","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106102","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106102"},"PeriodicalIF":7.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of opioid antagonist in patients with binge eating behavior: A systemic review and meta-analysis.","authors":"Yi-Ya Fang, Yi-Chun Yeh, Tai-Ling Liu, Hsu Tien-Wei, Chih-Hung Ko","doi":"10.1016/j.neubiorev.2025.106108","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106108","url":null,"abstract":"<p><strong>Background: </strong>Binge eating (BE) involves consuming unusually large amounts of food within a short period and feeling a loss of control. Neurobiological mechanisms underlying BE involve dysregulation of reward and inhibitory control systems, with the endogenous opioid system playing a key role. Opioid antagonists and the combination therapies with bupropion may have potential to reduce BE by affecting the reward system, but evidence regarding their effectiveness remains inconclusive. This meta-analysis reviewed randomized controlled trials (RCTs) exploring the effects of opioid antagonists on BE frequency, BE severity, body weight, and mood.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Cochrane CENTRAL, Web of Science, and ClinicalTrials.gov to identify RCTs published before May 14, 2023,. The primary outcomes were BE severity and frequency. The secondary outcomes were percentage change in body weight and depressive symptoms.</p><p><strong>Results: </strong>Eight RCTs were included in our analysis. Opioid antagonists significantly reduced BE frequency (standard difference in means [SMD] = -0.624, 95% confidence interval [CI] = -1.181 to -0.067, p = 0.028) and changes in body weight percentage (SMD = -0.981, 95% CI = -1.657 to -0.305, p = 0.004), with a moderate-to-large effect size. Conversely, opioid antagonists didn't significantly improve BE severity (Hedges' g = -0.210, 95% CI = -0.431 to 0.011, p = 0.063) or depressive symptoms (Hedges' g = -0.190, 95% CI = -0.434 to 0.053, p = 0.125). Meta-regression analysis revealed that the dosage of naltrexone served as a moderator in reducing BE frequency and body weight percentage.</p><p><strong>Conclusion: </strong>The present meta-analysis indicated that opioid antagonists effectively alleviate BE frequency and reduce percentage loss in body weight.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106108"},"PeriodicalIF":7.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastability in the Wild: A Scoping Review of Empirical Neuroimaging Studies in Humans.","authors":"Maria Teresa Wijaya, Sammi T S T Mabel-Kenzie, Guang Ouyang, Tatia M C Lee","doi":"10.1016/j.neubiorev.2025.106106","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106106","url":null,"abstract":"<p><p>Metastability is proposed as the mechanism supporting our adaptive responses to the environment. While extensive research has characterized brain metastability during rest and task performance, prior studies have mainly focused on understanding underlying mechanisms, with limited exploration of its application in mental processes and behaviors. This scoping review offers an overview of the existing empirical literature in this area. Through a systematic search that included 36 articles, our results reveal a predominance of resting-state fMRI studies, variability in how metastability is defined, and a lack of consideration for common confounds in neuroimaging data. The review concludes with suggestions for future research directions to address crucial unresolved issues in the field.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106106"},"PeriodicalIF":7.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value-based decision-making in non-suicidal self-injury: A systematic review and mini meta-analysis.","authors":"Yuhan Jiang, Ying Zeng, Mengli Zhang, Hongshuo Wang, Wei He, Pengfei Xu, Hui Ai","doi":"10.1016/j.neubiorev.2025.106107","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106107","url":null,"abstract":"<p><p>Non-suicidal self-injury (NSSI) is a significant global mental health issue. However, whether the deficit in value-based decision-making processing is the consistently key mechanisms of NSSI across studies with heterogeneous decision-making tasks remains uncertain. Hence, we reviewed literature on value-based decision-making and its moderating factors in NSSI, and then conducted a meta-analysis on studies in NSSI, specifically with Iowa Gambling Task. In total, 31 studies with 8417 participants aged from 8 to 50 were included in the systematic review of and 8 studies with 657 participants aged from 10 to 37 included in the meta-analysis. We found consistent impairments in value-based decision-making processing among individuals who engage in NSSI. Importantly, age is a significant moderator, with adolescents with NSSI performance worse, exhibiting increased reward sensitivity and preference for immediate rewards compared to other age groups. These results suggest the important role of value-based decision making in NSSI behaviors, especially during the development of adolescents. Our work provides new insights and integrative evidence for decision-making based prevention and intervention of NSSI.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106107"},"PeriodicalIF":7.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception and mental health in middle-aged and elderly adults: A systematic review and meta-analysis","authors":"Meiling Qi,&nbsp;Xiaona Shen,&nbsp;Yue Zeng,&nbsp;Xiaohe Lin,&nbsp;Muhammad Suliman,&nbsp;Ping Li","doi":"10.1016/j.neubiorev.2025.106104","DOIUrl":"10.1016/j.neubiorev.2025.106104","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies have identified interoceptive dysfunction as a critical biomarker for emotional disorders. It is well-established that aging correlates with a deterioration in interoceptive capabilities, which consequently affects emotional processing dynamics.</div></div><div><h3>Methods</h3><div>This study performed a systematic review and meta-analysis to evaluate the associations between interoceptive variants and mental health in middle-aged and elderly adults. Three English databases, including PubMed, Web of Science, and Medline (via EBSCO), were electronically searched from inception through December 2023. The study quality and meta-analysis were performed using the MMAT and RevMan 5.4 software.</div></div><div><h3>Results</h3><div>A total of 21 studies were included in this systematic review, and data from 14 studies were used in the meta-analysis. Favorable associations were seen between interoception and depression (pooled <em>r</em> = -0.11 (95CI%: −0.19 to −0.03), <em>z</em> = 2.72, <em>p</em> = 0.006, <em>I</em>^<em>2</em>= 0 %), alexithymia (pooled <em>r</em> = -0.25 (95CI%: −0.35 to −0.16), <em>z</em> = 4.84, <em>p</em> &lt; 0.001, <em>I</em>^<em>2</em>= 31 %), and emotion regulation (pooled <em>r</em> = 0.30 (95CI%: 0.18–0.41), <em>z</em> = 4.63, <em>p</em> &lt; 0.001, <em>I</em>^<em>2</em>= 33 %). Interoception showed no significant correlation with other mental health outcomes.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis underscore the importance of interoception in understanding the underlying neural mechanisms of depression, alexithymia, and emotion regulation in middle-aged and older adults. Interoceptive training could also potentially serve as an effective strategy for promoting mental health within this demographic.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106104"},"PeriodicalIF":7.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating neural substrates, diabetes self-management, and behavior change for tailored lifestyle interventions in type-2 diabetes: A neurobehavioral perspective","authors":"Danylo F. Cabral ,&nbsp;Marcelo Bigliassi ,&nbsp;Timothy P. Morris ,&nbsp;Joyce R. Gomes-Osman ,&nbsp;Peter J. Fried","doi":"10.1016/j.neubiorev.2025.106103","DOIUrl":"10.1016/j.neubiorev.2025.106103","url":null,"abstract":"<div><div>Understanding the neural mechanisms that underlie behavior change is critical for improving lifestyle management in type 2 diabetes. Individuals with type 2 diabetes face unique challenges in adopting and maintaining healthy behaviors, which can be influenced by alterations in brain function and plasticity, potentially leading to cognitive impairment. Diabetes self-management education and support (DSMES) programs aim to enhance lifestyle changes and promote better health outcomes while reducing cognitive decline. However, complex neural disruptions in critical regions for cognitive processes like the prefrontal cortex and parietal lobe present significant challenges. Given the likely role of neural mechanisms in behavioral choices, understanding how type 2 diabetes affects these neural substrates is crucial for developing effective interventions. Despite considerable research efforts aimed at testing lifestyle interventions, a critical gap remains in understanding the cognitive and behavioral components of successful diabetes self-management, the neural substrates of those components, and the impact of diabetes on those neural substrates. Bridging this gap necessitates a comprehensive examination integrating neural processes, DSMES strategies, and behavior change models. Thus, this perspective review highlights the urgent need to address the knowledge gaps surrounding the neural correlates of diabetes self-management and the integration of behavioral models into intervention frameworks. We propose a hypothesis-generating question and present preliminary findings comparing neural plasticity, executive functions, and lifestyle behavior among individuals with type 2 diabetes, pre-diabetes, and healthy controls. By elucidating the neural substrates underpinning diabetes and exploring their implications for DSMES and readiness to change, we can pave the way for more effective, personalized approaches to diabetes care.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106103"},"PeriodicalIF":7.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social and affective neuroscience and the emergence of the study of empathy related behaviors in rodents","authors":"M.L. Smith","doi":"10.1016/j.neubiorev.2025.106105","DOIUrl":"10.1016/j.neubiorev.2025.106105","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106105"},"PeriodicalIF":7.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain network alterations in fragile X syndrome","authors":"Flavia Venetucci Gouveia ,&nbsp;Jürgen Germann ,&nbsp;George M. Ibrahim","doi":"10.1016/j.neubiorev.2025.106101","DOIUrl":"10.1016/j.neubiorev.2025.106101","url":null,"abstract":"<div><div>Fragile X syndrome (FXS), caused by <em>FMR1</em> gene mutations, leads to widespread brain alterations significantly impacting cognition and behaviour. Recent advances have provided a deeper understanding of the neural substrates of FXS. This review provides a comprehensive overview of the current knowledge of neuronal network alterations in FXS. We highlight imaging studies that demonstrate network-level disruptions within resting-state networks, including the default mode network, frontoparietal network, salience network, and basal ganglia network, linked to cognitive, emotional and motor deficits in FXS. Next, we link dysregulated network activity in FXS to molecular studies showing neurometabolic imbalances, particularly in GABAergic and glutamatergic systems. Additionally, gene-brain-behavior correlations are explored with gene expression maps to illustrate regional <em>FMR1</em> expression patterns tied to clinical symptoms. A graph analysis and meta-analytic mapping further link these dysfunctional networks to the specific symptoms of FXS. We conclude by highlighting gaps in the literature, including the need for greater global collaboration, inclusion of underrepresented populations, and consideration of transdiagnostic effects in future research to advance neuroimaging and therapeutic approaches for FXS.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106101"},"PeriodicalIF":7.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding play from neurobiological, evolutionary, and comparative perspectives","authors":"Jeffrey C. Schank ,&nbsp;Gordon M. Burghardt ,&nbsp;Elisabetta Palagi ,&nbsp;Sergio M. Pellis","doi":"10.1016/j.neubiorev.2025.106100","DOIUrl":"10.1016/j.neubiorev.2025.106100","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106100"},"PeriodicalIF":7.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embedding emotion concepts in cognitive maps","authors":"Yumeng Ma,&nbsp;Nilofar Vafaie,&nbsp;Philip A. Kragel","doi":"10.1016/j.neubiorev.2025.106089","DOIUrl":"10.1016/j.neubiorev.2025.106089","url":null,"abstract":"<div><div>Emotion knowledge is organized in a two-dimensional space known as the affective circumplex, which is thought to develop from core affective feelings and the co-occurrence of emotional events. Neural studies reveal that emotion concepts and cognitive maps of space and abstract concepts are represented in hippocampal-prefrontal systems. We propose that the circumplex is formed by learning the transitions between emotion concepts, a process mediated by a reciprocal network involving hippocampal cells that encode emotion concepts and grid cells in medial entorhinal and ventral prefrontal cortices that encode the relations between them. We anticipate that testing this hypothesis will shed light on the debate about whether emotions are biologically basic or constructed from core affective dimensions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106089"},"PeriodicalIF":7.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}