Neuroscience and Biobehavioral Reviews最新文献

{"title":"A pre-registered scoping review of neuroimaging evidence concerning lexico-semantic processing in multilingual speakers","authors":"Abigail E. Licata,&nbsp;Marion Bouffier,&nbsp;Valentina Borghesani","doi":"10.1016/j.neubiorev.2026.106591","DOIUrl":"10.1016/j.neubiorev.2026.106591","url":null,"abstract":"<div><div>This scoping review examines neuroimaging and neurophysiology methodologies and findings related to lexico-semantic processing in multilingual individuals. To understand what functional neuroimaging and neurophysiology results have been associated with multilingual lexico-semantic processing and to what extent these findings converge, we analyzed 163 studies utilizing fMRI, fNIRS, EEG, and MEG, focusing on the paradigms employed, language assessment approaches, and reported neural correlates. Our review revealed that while lexico-semantic representations in the first language (L1) and second language (L2) become increasingly similar with greater L2 experience, this similarity is modulated by the specific lexico-semantic process under investigation. We highlight the differential role of language experience variables on lexico-semantic processes, including embodied processing. We incorporate studies of unimodal and bimodal signing bilinguals to move beyond the speech modality, combining research populations that have been typically reviewed separately, to summarize evidence on language experience and cross-modal transfer of lexico-semantic processes in multilinguals. Furthermore, we underscore a critical need for increased data and code transparency in the field to enhance reproducibility and facilitate a cumulative understanding of multilingual lexico-semantic processing. This review identifies key gaps in the literature and offers recommendations for future research to advance our understanding of how multilingualism shapes the neural organization of lexico-semantic knowledge.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106591"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Poverty Ecosystem Framework: An integrative review of candidate mechanisms underlying the effects of poverty on neurocognitive development in the first 1000 days of life","authors":"Nadya Ali ,&nbsp;Freek van der Heijden ,&nbsp;Wouter De Baene ,&nbsp;Marion I. van den Heuvel ,&nbsp;Margriet Sitskoorn","doi":"10.1016/j.neubiorev.2026.106605","DOIUrl":"10.1016/j.neubiorev.2026.106605","url":null,"abstract":"<div><div>Early-life poverty has been associated with lasting alterations in brain development, cognitive abilities, health and quality of life. The potential pathways linking poverty to neurocognitive development remain unclear partly because they are scattered across disciplines. This integrative review synthesises multidisciplinary findings pertaining to candidate mechanisms of the relationship between poverty and neurocognitive development into a unified conceptual framework. We systematically searched PubMed, Web of Science, and PsycINFO for articles published between the years 2014 and 2026. The included studies (n = 59) were examined for potential pathways linking poverty to neurocognitive outcomes in the first 2 years of life. Candidate mediating mechanisms were divided into three levels, forming the ‘<em>Poverty Ecosystem Framework’:</em> (1) external level (environment), (2) internal system level (biological pathways), and (3) cellular level (molecular processes). Across studies, poverty was frequently associated with adverse neurocognitive outcomes and increased susceptibility to stressors. Evidence pertaining to the underlying mechanisms was more mixed, however. Our synthesis suggests that poverty's impact is twofold, involving both the direct harm of deprivation and a potential recalibration of developmental sensitivity that primes the brain to respond differently to subsequent stressors. Additionally, parental education emerged as a buffer for the effect of low income and different physiological stressors on child neurocognition. Complementary to the synthesis, an interactive dashboard was created that visualises key findings. This ecosystem perspective demonstrates the necessity of applying consistent indices of poverty and studying interacting risk factors, rather than isolated variables, to fully understand and mitigate poverty's impact on the developing brain.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106605"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prenatal omega-3 fatty acids supplementation on cognitive outcomes: A systematic review with meta-analysis","authors":"Chiara Musillo,&nbsp;Marianna Samà,&nbsp;Marta Borgi,&nbsp;Francesca Cirulli","doi":"10.1016/j.neubiorev.2026.106589","DOIUrl":"10.1016/j.neubiorev.2026.106589","url":null,"abstract":"<div><div>The beneficial effects of omega-3 polyunsaturated fatty acids (PUFA) supplementation during pregnancy have been associated with reduced risk of preterm birth and low birthweight. However, inconsistent findings have been reported regarding their impact on children’s neurodevelopmental trajectories. We performed a comprehensive systematic review with meta-analysis of preclinical studies to assess the effects of prenatal omega-3 supplementation on long-term outcomes in offspring and to identify key relevant neurodevelopmental domains to guide the design and prioritization of future clinical follow-up studies. The databases consulted included PubMed/Medline, Scopus and Web of Science. Thirty-five studies were included in the systematic review, and 19 studies were included in the meta-analysis. Relevant information such as characteristics of nutritional interventions, maternal conditions, offspring characteristics and article attributes were extracted. Sample sizes, means, and standard deviation or standard error for the outcome measures were also extracted. The search yielded 3198 articles; 35 met inclusion criteria, with 11 included in a random-effects meta-analysis of memory retention, and 8 in a meta-analysis of brain-derived neurotrophic factor (BDNF) levels. Our findings show that maternal omega-3 PUFA supplementation during pregnancy improves memory retention (SMD=0.671; CI 95 %: 0.163–1.179; p = 0.010) and increases levels of BDNF (SMD=0.838; CI 95 %: 0.369–1.307; p = 0.000) in the offspring. These effects are more pronounced in offspring exposed to prenatal adversities. Maternal omega-3 supplementation shows promise in mitigating oxidative stress and inflammation, although findings remain heterogeneous. Maternal omega-3 supplementation appears as a safe and effective means to improve offspring neurodevelopment, with stronger effects under adverse gestational conditions, highlighting its potential for at-risk populations.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106589"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of acute hypoxia and cognition: Domain-specific effects and the role of barometric pressure and carbon dioxide","authors":"Peter Michael Bloomfield ,&nbsp;Charlotte Joy Waikauri Connell ,&nbsp;David M. Shaw ,&nbsp;Jui-Lin Fan ,&nbsp;James P. Fisher ,&nbsp;Nicholas Gant","doi":"10.1016/j.neubiorev.2026.106603","DOIUrl":"10.1016/j.neubiorev.2026.106603","url":null,"abstract":"<div><div>This systematic review and meta-analysis examined the effects of acute hypoxia, barometric pressure and supplemental carbon dioxide on cognition. Five databases were searched, yielding 137 eligible records and 458 effect sizes. Risk of bias was assessed using the Rosendal score; mean (SD) score was 48 (15) %, indicating moderate study quality. Random effects meta-analyses assessed the effect of hypoxia on all effect sizes, on the speed and accuracy components of attention, memory, information processing, crystallised intelligence (learned knowledge and skills), executive function and reaction time, and the effect of supplemental carbon dioxide on performance. Effects of hypoxia on response speed and accuracy and of barometric pressure on cognition were investigated by meta-regression. When combining all effect sizes, cognition was impaired by hypoxia (Hedges’ g: −0.48, 95 % confidence interval [CI]: −0.62 to −0.33) and was worse under normobaric than hypobaric conditions (Hedges’ g difference: −0.58, 95 % CI: −0.87 to −0.30). Response accuracy was impaired more than response speed (Hedges’ g difference: −0.38, 95 % CI: −0.09 to −0.67). Accuracy was impaired in the attention, crystallised intelligence, executive function and memory domains. Speed was impaired in the attention domain only. Seventeen effect sizes investigated the effect of supplemental carbon dioxide. Cognition was worse under poikilocapnic than isocapnic or hypercapnic hypoxia (Hedges’ g: −1.55, 95 % CI: −2.59 to −0.53). These findings are important for groups at risk of low oxygen exposure, as they enhance understanding of how hypoxia impairs cognition and can improve hypoxia recognition and recovery training in operational settings.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106603"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different dietary restriction regimens on cognitive function and pathological markers in Alzheimer's disease mouse models: A systematic review and meta-analysis","authors":"Lirui Sun ,&nbsp;Xinyi Xu ,&nbsp;Zihan Wang ,&nbsp;Yuhan Meng ,&nbsp;Ye Li ,&nbsp;Yumeng Hou ,&nbsp;Xiaohui Gao ,&nbsp;Huixian Cui ,&nbsp;Yan Li","doi":"10.1016/j.neubiorev.2026.106601","DOIUrl":"10.1016/j.neubiorev.2026.106601","url":null,"abstract":"<div><div>Dietary restriction (DR) has emerged as a promising non-pharmacological intervention for Alzheimer’s disease (AD). This systematic review and meta-analysis provides the first comprehensive comparison of five dietary restriction regimens in Alzheimer's disease mouse models. Analysis of 23 studies demonstrates that caloric restriction yields the most consistent benefits. While intermittent fasting exhibits model-dependent efficacy—improving recognition memory but exacerbating neuroinflammation in 5 ×FAD models. The fasting-mimicking diet showed the largest effect size. From a geroscience perspective, these findings support a precision nutrition framework for Alzheimer's disease, suggesting that future interventions should be tailored to individual pathological profile, inflammatory status, and impaired cognitive subdomains to optimize therapeutic efficacy.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106601"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCL12/CXCR4 axis as a modulator of neurotransmission in depression: A neuroimmune perspective.","authors":"Kinga Grzybowska, Piotr Czarny, Łukasz Kołodziej, Paulina Wigner-Jeziorska, Janusz Szemraj, Piotr Gałecki, Kuan-Pin Su, Tomasz Śliwiński","doi":"10.1016/j.neubiorev.2026.106717","DOIUrl":"10.1016/j.neubiorev.2026.106717","url":null,"abstract":"<p><p>Major Depressive Disorder (MDD) is characterized by heterogeneous pathogenesis that extends beyond traditional monoamine deficits. A paradigm shift is recognizing neuroinflammation as a central, critical driver of both illness onset and resistance to treatment. The CXCL12/CXCR4 system is traditionally associated with immune cell trafficking, but increasing evidence reveals its powerful regulatory role in neuropsychiatric disorders. We performed a comprehensive synthesis demonstrating that CXCL12/CXCR4 axis acts as a direct molecular modulator of neurotransmission, neuroplasticity, and glial cell signaling. Specifically, this axis can modulate a multiple molecular pathways linked with the glutaminergic, GABAergic, and serotonergic systems, and mediating neuroplasticity and glial cell function. Functionally, CXCL12/CXCR4 axis has twofold character - it can strengthen neurotoxic processes through overactivation of NMDAR and excessive Ca2 + influx. On the other hand, it can also play protective role by preventing excitotoxicity, supporting neurogenesis, enhancing GABA synthesis, and dendritic spines stabilization. This review focuses on identifying potential mechanisms across in vitro, animal, and human studies to establish the CXCL12/CXCR4 axis as a powerful biomarker and, critically, an unexploited therapeutic target.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106717"},"PeriodicalIF":7.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the Link Between Cognitive Control and Emotion Regulation: A Meta-Analytic Review.","authors":"Katrin Schulze, Ilka Mueller, Daniel V Holt, Sam Putz, Sven Barnow, Luise Pruessner","doi":"10.1016/j.neubiorev.2026.106708","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106708","url":null,"abstract":"<p><p>Emotion regulation is essential for adaptive behavior and mental health. Dominant theoretical frameworks, together with influential neuroscientific accounts, suggest that emotion regulation is closely linked to cognitive control processes; however, behavioral evidence supporting this link remains inconsistent. To quantify these associations, a comprehensive meta-analysis was conducted to examine the relationship between individual differences in cognitive control (updating, inhibition, shifting) and four emotion regulation strategies: reappraisal (k = 70 studies, N = 10,524), suppression (k = 45, N = 5,104), rumination (k = 109, N = 10,637), and worry (k = 36, N = 3,385). Individuals with stronger cognitive control abilities showed more frequent and more effective use of reappraisal and engaged less in rumination and worry, whereas suppression showed no consistent relation. Component-level analyses suggested associations with inhibition and updating, but not shifting, with stronger effects for regulation ability than for strategy use frequency. While all notable effects were conceptually consistent, their magnitudes (rs < |.15|) were small and substantially lower than those implied by prior theoretical frameworks and influential empirical studies. Moreover, the effects showed considerable heterogeneity and substantial uncertainty. Overall, these results challenge the widely held assumption that cognitive control and emotion regulation are closely linked, indicating instead that their associations are weaker and more specific than commonly assumed. They further suggest that dominant theoretical frameworks may overestimate the strength of this link at the behavioral level, highlighting the need for more ecologically valid assessments of both cognitive control and emotion regulation.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106708"},"PeriodicalIF":7.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review of brain entropy as a biomarker of the psychedelic state.","authors":"Bruno Moses, Manoj K Doss, Enzo Tagliazucchi","doi":"10.1016/j.neubiorev.2026.106720","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106720","url":null,"abstract":"<p><p>Serotonergic psychedelics induce profound alterations in consciousness, giving rise to an altered state commonly referred to as the psychedelic state. The entropic brain hypothesis proposes that brain entropy (i.e., the degree of uncertainty in the distribution of brain states) is elevated during the psychedelic state, as well as in other states characterized by an expanded breadth of phenomenal consciousness, whereas the opposite pattern is observed in states of diminished or absent consciousness. Given the numerous neuroimaging studies reporting heightened entropy under psychedelics, a substantial portion of the field has embraced entropy as a reliable biomarker of the psychedelic state. We argue that this view may be inherently oversimplified and offer a more nuanced and comprehensive perspective. We first review evidence supporting the use of entropy metrics and discuss their potential utility. We then identify key empirical, methodological, and conceptual challenges associated with using brain entropy as a psychedelic biomarker, organized into four themes: (1) entropy alterations are not specific to psychedelics or other states of heightened phenomenal richness; (2) current entropy-based approaches do not accommodate multidimensional operationalizations of conscious states; (3) multiple entropy metrics exist, each with distinct interpretations and varying levels of mutual consistency; and (4) limited evidence supports the neurophenomenological equivalence between brain entropy and phenomenal richness. Although substantial questions remain about the validity of entropy-based biomarkers of the psychedelic state, we conclude that the concept warrants further investigation and offer practical suggestions for future research to address these limitations.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"186 ","pages":"106720"},"PeriodicalIF":7.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The amygdala and perirhinal cortex sometimes cooperate but often compete during information processing in rats, cats, and people.","authors":"Nathan M Holmes, Melie Talaron, A Simon Killcross, Vincent Laurent, Nura Lingawi, Fred Westbrook","doi":"10.1016/j.neubiorev.2026.106705","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2026.106705","url":null,"abstract":"<p><p>The amygdala is a medial temporal lobe (MTL) structure that processes emotionally significant information. It is strongly interconnected with other MTL regions, including the perirhinal cortex (PRh) which is a site of convergence for different types of sensory information, e.g., auditory, visual, olfactory, gustatory and tactile. The amygdala and PRh have been shown to cooperate when processing emotional and sensory information via the amygdala modulating or facilitating sensory processing in the PRh. However, the two regions have also been shown to compete during some types of tasks, raising questions about the nature of their interaction. This paper reviews theories of amygdala and perirhinal cortex function derived from studies in monkeys, cats and rats. It also reviews findings from a sensory preconditioning protocol which has been used to study how these regions encode and integrate different types of information in rats, and a selection of neuroimaging studies that have produced analogous results in people. It concludes with a perspective on amygdala-rhinal interactions that addresses how and why the amygdala and PRh sometimes cooperate and often compete when processing different types of information.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106705"},"PeriodicalIF":7.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of pharmacological effects on human aversive memory","authors":"Yanfang Xia ,&nbsp;Boris B. Quednow ,&nbsp;Dominik R. Bach","doi":"10.1016/j.neubiorev.2026.106548","DOIUrl":"10.1016/j.neubiorev.2026.106548","url":null,"abstract":"<div><div>A large body of work has investigated the effect of various pharmacological compounds on aversive memory formation, retrieval, and modification in humans. A broad overview across signalling pathways and memory models is currently lacking. Here, we systematically review publications that tested the impact of acute pharmacological interventions on aversive memory in healthy humans, following PRISMA-2020. We identified 215 candidate compounds from 17 systems and searched PubMed, Web of Science and Scopus, until 14 June 2024. We identified 100 publications with 36 compounds targeting 13 systems. Three compounds were used by the majority of studies: hydrocortisone (n = 25), propranolol (n = 19), and <span>D</span>-cycloserine (n = 8), while many of the remaining 33 compounds were investigated in single studies only. We summarise the effect of each investigated compound across memory models, according to the targeted memory stage. Solid evidence emerges for an impact of propranolol on reconsolidation, and weak evidence for an impact of propranolol, 3,4-methylenedioxymethamphetamine (MDMA), benzodiazepines, yohimbine, reboxetine, and <span>D</span>-cycloserine on aversive memory encoding/consolidation, and valproic acid on extinction encoding/consolidation. Furthermore, 15 compounds showed significant effects in individual studies with no published replication attempts to date. We discuss potential research directions and suggest steps for greater comparability of findings between compounds, memory models, and laboratories.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106548"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}