Neuroscience and Biobehavioral Reviews最新文献

{"title":"High rates of Parkinson’s disease diagnosis in the autistic population: True co-occurrence or a product of overlapping traits?","authors":"Lydia J. Hickman ,&nbsp;Jennifer L. Cook","doi":"10.1016/j.neubiorev.2025.106261","DOIUrl":"10.1016/j.neubiorev.2025.106261","url":null,"abstract":"<div><div>Older autistic adult literature is sparse, and little is known about the aging autistic population. However, recent evidence suggests an increased prevalence of Parkinson’s disease (PD) diagnosis in the autistic population. It may initially be assumed that autistic individuals are genetically more likely to develop PD, but extant genetic studies do not provide strong evidence for a link between the two conditions. An underappreciated body of evidence may shed light upon why autistic individuals score highly on PD diagnostic criteria: movement differences in autism have been likened to PD. Given that PD diagnosis is primarily movement-based, if it is the case that autistic movement appears parkinsonian, this may facilitate autistic individuals meeting diagnostic criteria for PD. If validated, this theory could have serious implications for the specificity of the PD diagnostic process. Here, we set out the evidence for high rates of PD diagnosis and parkinsonism in the autistic population and subsequently question why this might be the case, making reference to genetic and behavioural similarities between autism and PD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106261"},"PeriodicalIF":7.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin in clinical settings: A three-stage roadmap for responsible translation","authors":"Madelon M.E. Riem ,&nbsp;Marinus H. van IJzendoorn ,&nbsp;Marian J. Bakermans-Kranenburg","doi":"10.1016/j.neubiorev.2025.106257","DOIUrl":"10.1016/j.neubiorev.2025.106257","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106257"},"PeriodicalIF":7.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of light exposure on vagally-mediated heart rate variability: A systematic review","authors":"Vanessa Martins ,&nbsp;Mark S. Allen ,&nbsp;Uirassu Borges ,&nbsp;Pauline Laterza ,&nbsp;Marko Jackovič ,&nbsp;Emma Mosley ,&nbsp;Florian Javelle ,&nbsp;Sylvain Laborde","doi":"10.1016/j.neubiorev.2025.106241","DOIUrl":"10.1016/j.neubiorev.2025.106241","url":null,"abstract":"<div><h3>Background</h3><div>Light therapy is increasingly used to address disorders such as depression, anxiety, sleep disturbances, and seasonal affective disorder. Autonomic dysfunction, common in these conditions, may be modulated by light through its effects on cardiac vagal activity, indexed by vagally-mediated heart rate variability (vmHRV).</div></div><div><h3>Objective</h3><div>This systematic review synthesized evidence on the effects of ocular exposure to visible light (illuminance and color) on vmHRV in healthy and clinical populations.</div></div><div><h3>Method</h3><div>Following PRISMA guidelines, an electronic search of MEDLINE (via PubMed), Web of Science, Cochrane, and ProQuest was conducted in June 2024. Using the PICOS criteria, 24,673 records were screened, with 25 studies included. Risk of bias was assessed with the Cochrane Risk of Bias 2 tool.</div></div><div><h3>Results</h3><div>All included studies were rated as high risk of bias. High-illuminance blue light was generally associated with reduced vmHRV, likely due to its arousal-promoting effects. Conversely, lower-illuminance warm-colored light (e.g., red or dim white light) showed potential to increase vmHRV, indicating a calming effect. However, findings were inconsistent due to methodological heterogeneity, including variability in populations, exposure protocols, and control conditions.</div></div><div><h3>Conclusion</h3><div>While ocular light exposure shows promise for modulating vmHRV, the high risk of bias and variability across studies limit clinical application. Future research should adopt standardized protocols, account for confounding variables, and explore long-term interventions to better evaluate light’s therapeutic potential for autonomic regulation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106241"},"PeriodicalIF":7.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"My personal goodbye to all the NBR community.","authors":"Giovanni Laviola","doi":"10.1016/j.neubiorev.2025.106256","DOIUrl":"10.1016/j.neubiorev.2025.106256","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106256"},"PeriodicalIF":7.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Associations of microbiome pathophysiology with social activity and behavior are mediated by epigenetic modulations: Avenues for designing innovative therapeutic strategies” [Neurosci. Biobehav. Rev. 174 (2025) 106208]","authors":"Shabnam Nohesara ,&nbsp;Hamid Mostafavi Abdolmaleky ,&nbsp;Faith Dickerson ,&nbsp;Adrian A. Pinto-Tomas ,&nbsp;Dilip V. Jeste ,&nbsp;Sam Thiagalingam","doi":"10.1016/j.neubiorev.2025.106240","DOIUrl":"10.1016/j.neubiorev.2025.106240","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106240"},"PeriodicalIF":7.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of hyperscanning in clinical encounters","authors":"Lena Adel ,&nbsp;Lisane Moses ,&nbsp;Elisabeth Irvine ,&nbsp;Kyle T. Greenway ,&nbsp;Guillaume Dumas ,&nbsp;Michael Lifshitz","doi":"10.1016/j.neubiorev.2025.106248","DOIUrl":"10.1016/j.neubiorev.2025.106248","url":null,"abstract":"<div><div>Therapeutic alliance is defined as the collaborative relationship between patient and therapist. Strong therapeutic alliances have been associated with positive clinical outcomes, but much remains unknown about alliance and its physiological basis. Interpersonal neural synchrony (INS) – the synchronization of neural signals between interacting individuals – is emerging as a novel lens for studying interactions with relatively objective and time-sensitive neuroimaging techniques. We searched four databases to identify studies of INS in clinical encounters. Our search yielded 161 articles, 46 met criteria for full-text review and 11 were included. The included articles reported INS across a total of 160 dyads, all published since 2018. Despite diverse methodologies, INS was observed in all studies and was often related to therapeutic outcomes. However, results were mixed regarding associations between INS and therapeutic alliance. These results highlight that, while promising, additional research is needed to elucidate the relationship between INS, therapeutic alliance and clinical outcomes. Future studies should aim to standardize methodologies, explore temporal dynamics (e.g., through longitudinal assessments), and include larger sample sizes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106248"},"PeriodicalIF":7.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data interoperability for a systems approach to developmental conditions","authors":"Féline Mollerus ,&nbsp;Cecil Lynch ,&nbsp;Hilgo Bruining","doi":"10.1016/j.neubiorev.2025.106245","DOIUrl":"10.1016/j.neubiorev.2025.106245","url":null,"abstract":"<div><div>The rising prevalence of developmental conditions such as autism, ADHD, and learning disorders underscores the urgent need for an integrated approach to account for the dynamic interaction between genetic, environmental, and societal factors. At present, the information on these factors is scattered and fragmented across a wide range of caregivers using different systems, structures and semantics. As a result, healthcare providers often face excessive administrative burdens to gather relevant information from disparate sources, and in many cases, must repeat diagnostic tests due to a lack of accessible prior records. This fragmentation also has a significant impact on patients and families, who may experience delays in care, repeated procedures, inconsistent treatment, and ultimately poorer health outcomes, which highlights the urgent need for an interoperable foundation.</div><div>In this perspective, we emphasize the transformative potential of data interoperability as a prerequisite for adopting a complex systems approach to developmental conditions. We discuss key concepts, implementation barriers, and strategies for achieving interoperability, including standards like FHIR and SNOMED CT, while addressing security and regulatory concerns. Our research proposes crucial steps to realize interoperability that require collaborative efforts across healthcare providers, technology developers, policymakers, and researchers. Through practical case examples, we demonstrate how interoperability enhances cross-disciplinary collaboration, reduces duplicative data entry, and provides a more comprehensive view of patient health trajectories, particularly valuable for complex conditions requiring multiple specialists and long-term care. Furthermore, our research shows that interoperable systems lay the foundation for advanced analytics and artificial intelligence initiatives, enabling more accurate diagnoses, personalized treatment plans, and improved prediction of clinical outcomes for developmental conditions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106245"},"PeriodicalIF":7.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The exposome from neurodevelopment to neurodegeneration: A narrative review","authors":"Sveva Dallere ,&nbsp;Daniela Maria Rasà ,&nbsp;Gianna Pavarino ,&nbsp;Roberta Schellino ,&nbsp;Alessandro Vercelli ,&nbsp;Marina Boido","doi":"10.1016/j.neubiorev.2025.106247","DOIUrl":"10.1016/j.neubiorev.2025.106247","url":null,"abstract":"<div><div>Inspired from the historical debate “nature” versus “nurture”, the concept “exposome” recently emerged as a comprehensive framework encompassing the totality of exposures individuals experience, from conception onward, over a complete lifetime, and how they can affect human health. In this narrative review, we present an overview of current knowledge on the exposome, with a particular focus on its impact on brain health across different life stages, highlighting its role during neurodevelopment/childhood, adulthood, physiological aging and neurodegenerative conditions. We explore the three main exposome domains (general external, specific external, internal), underpinning their interconnection. We also provide examples of how specific factors, ranging from chemicals to lifestyle habits, can either positively or negatively influence the CNS structure and function. To this aim, we included articles (mostly between 2005 and 2024) found in open-access databases, selected using the following search terms: “exposome”, “central nervous system” and “pregnancy” or “childhood” or “adulthood” or “aging” or “neurodegeneration”. Second, we analyzed the relationships between specific exposome domains and each stage of life. Only articles addressing a given risk factor across all life stages were included in the review. In each chapter, we review findings from both human and experimental studies, when available, with an insight on biological mechanisms, in order to link exposure to phenotype. This work highlights the potential of the exposomics’ framework to support public health policies and facilitate the prevention and treatment of multifactorial neurological disorders, while underscoring the importance of interdisciplinary efforts to address the multifaceted environmental determinants endangering the CNS health.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106247"},"PeriodicalIF":7.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of mental disorder symptoms among university students: An umbrella review","authors":"Ursula Paiva ,&nbsp;Samuele Cortese ,&nbsp;Martina Flor ,&nbsp;Andrés Moncada-Parra ,&nbsp;Arturo Lecumberri ,&nbsp;Luis Eudave ,&nbsp;Sara Magallón ,&nbsp;Sara García-González ,&nbsp;Ángel Sobrino-Morras ,&nbsp;Isabella Piqué ,&nbsp;Gemma Mestre-Bach ,&nbsp;Marco Solmi ,&nbsp;Gonzalo Arrondo","doi":"10.1016/j.neubiorev.2025.106244","DOIUrl":"10.1016/j.neubiorev.2025.106244","url":null,"abstract":"<div><div>This umbrella review synthesizes data on the prevalence of mental disorder symptoms among university students worldwide. A systematic search of seven databases (inception–July 23, 2023) followed PRISMA guidelines. We included meta-analyses assessing the prevalence of mental disorder symptoms, evaluating methodological quality with AMSTAR-2. A random-effects meta-analysis was conducted, along with meta-regression and subgroup analyses for moderators (percentage of females, publication date, healthcare-related degrees, COVID-19 pandemic). We included 1,655 primary studies from 62 meta-analyses, encompassing 8,706,185 participants. AMSTAR-2 ratings classified 35 % of meta-analyses as low quality and 65 % as critically low. Pooled prevalence estimates were: depression—mild (35.41 %, CI=33.9–36.93) and severe (13.42 %, CI=8.03–19.92; k=952; n=2,108,813); anxiety—mild (40.21 %, CI=37.39–43.07) and severe (16.79 %, CI=7.21–29.29; k=433; n=1,579,780); sleep disorders (41.09 %, CI=35.7–46.58); eating disorders (17.94 %, CI=15.79–20.20); gambling disorder (6.59 %, CI=5.52–7.75); post-traumatic stress disorder (25.13 %, CI=20.55–30.02); stress (36.34 %, CI=29.36–43.62); and suicide-related outcomes (ideation past 12 months: 10.76 %, CI=9.53–12.06; lifetime ideation: 20.33 %, CI=16.15–24.86; suicide attempt past 12 months: 1.37 %, CI=0.67–2.29; lifetime attempt: 3.44 %, CI=2.48–4.54). Meta-regression analyses identified statistically significant moderators of prevalence such as healthcare academic degrees and the pandemic in the case of depression and studies with more females in the case of sleep disorders. This is the most comprehensive synthesis on the prevalence of mental disorder symptoms in university students, providing crucial insights for clinicians, policymakers, and stakeholders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106244"},"PeriodicalIF":7.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary interventions targeting the neurolipidome in epilepsy: From preclinical models to clinical applications and future therapeutic approaches","authors":"Hasti Fadakar ,&nbsp;Priyanka Rudra ,&nbsp;Apil Adhikari ,&nbsp;Galhenage Kethmi Perera ,&nbsp;Vichari Sirimanne ,&nbsp;Dayajyot Kaur ,&nbsp;Huon Wong ,&nbsp;Kwan Yiu Yiu ,&nbsp;Daniel Schweitzer ,&nbsp;Isaac Oluwatobi Akefe","doi":"10.1016/j.neubiorev.2025.106242","DOIUrl":"10.1016/j.neubiorev.2025.106242","url":null,"abstract":"<div><div>Epilepsy is a neurological disorder affecting approximately 50 million people globally and is characterised by recurrent, unprovoked seizures resulting from abnormal, excessive synchronised firing of neurons. Developing new therapeutic targets and biomarkers is key to improving the diagnosis, treatment, and management. This scoping review examines the current literature on the preclinical and clinical applications of dietary interventions that target the neurolipidome in epilepsy. Specifically, it investigates the role of lipids in the underlying pathogenesis of epilepsy. A comprehensive search of databases was conducted to identify peer-reviewed articles published in the past ten years. Original research articles focusing on both adult and paediatric epilepsy and disrupted lipid metabolism were included, resulting in a total of 101 papers. Our review identified several key lipids implicated in the pathogenesis of epilepsy, including sphingolipids, free fatty acids, endocannabinoids, cholesterol, triglycerides, and phospholipids, and also explores the complex interactions between these lipids and their roles in the disease process. Furthermore, our study highlighted that the Ketogenic Diet (KD) and Modified Atkins Diet (MAD) have proven effective adjunctive or alternative treatments in paediatric and adult populations, improving patient quality of life and reducing seizure frequency. Additionally, treatment with lipid-based supplements, such as eicosapentaenoic acid, docosahexaenoic acid, fish oil, and cannabidiol, has been associated with a reduction in seizure rates in patients with drug-resistant epilepsy. In summary, findings from this study indicate that KD and MAD lipid-based supplements are effective for managing epilepsy in paediatrics, adults, and animal models. However, further research is necessary to elucidate the pathophysiological mechanisms underlying the role of lipids in the development and progression of epilepsy.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106242"},"PeriodicalIF":7.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}