Neuroscience and Biobehavioral Reviews最新文献_第2页

Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer’s disease 在阿尔茨海默病的发生和发展过程中，补体 3a 通过线粒体依赖性 NLRP3 激活机制中的 C3aR 诱导突触丧失。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-30 DOI: 10.1016/j.neubiorev.2024.105868

{"title":"Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer’s disease","authors":"","doi":"10.1016/j.neubiorev.2024.105868","DOIUrl":"10.1016/j.neubiorev.2024.105868","url":null,"abstract":"<div><p>As a central molecule in complement system (CS), complement (C) 3 is upregulated in the patients and animal models of Alzheimer’s disease (AD). C3 will metabolize to iC3b and C3a. iC3b is responsible for clearing β-amyloid protein (Aβ). In this scenario, C3 exerts neuroprotective effects against the disease via iC3b. However, C3a will inhibit microglia to clear the Aβ, leading to the deposition of Aβ and impair the functions of synapses. To their effects on AD, activation of C3a and C3a receptor (C3aR) will impair the mitochondria, leading to the release of reactive oxygen species (ROS), which activates the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasomes. The overloading of NLRP3 inflammasomes activate microglia, leading to the formation of inflammatory environment. The inflammatory environment will facilitate the deposition of Aβ and abnormal synapse pruning, which results in the progression of AD. Therefore, the current review will decipher the mechanisms of C3a inducing the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms, which facilitates the understanding the AD.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interoception, network physiology and the emergence of bodily self-awareness 互感、网络生理学和身体自我意识的出现。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-30 DOI: 10.1016/j.neubiorev.2024.105864

{"title":"Interoception, network physiology and the emergence of bodily self-awareness","authors":"","doi":"10.1016/j.neubiorev.2024.105864","DOIUrl":"10.1016/j.neubiorev.2024.105864","url":null,"abstract":"<div><p>The interplay between the brain and interoceptive signals is key in maintaining internal balance and orchestrating neural dynamics, encompassing influences on perceptual and self-awareness. Central to this interplay is the differentiation between the external world, others and the self, a cornerstone in the construction of bodily self-awareness. This review synthesizes physiological and behavioral evidence illustrating how interoceptive signals can mediate or influence bodily self-awareness, by encompassing interactions with various sensory modalities. To deepen our understanding of the basis of bodily self-awareness, we propose a network physiology perspective. This approach explores complex neural computations across multiple nodes, shifting the focus from localized areas to large-scale neural networks. It examines how these networks operate in parallel with and adapt to changes in visceral activities. Within this framework, we propose to investigate physiological factors that disrupt bodily self-awareness, emphasizing the impact of interoceptive pathway disruptions, offering insights across several clinical contexts. This integrative perspective not only can enhance the accuracy of mental health assessments but also paves the way for targeted interventions.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003336/pdfft?md5=dcf80a4ff30ca582e1069d46a4c7eeaf&pid=1-s2.0-S0149763424003336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial attention in three-dimensional space: A meta-analysis for the near advantage in target detection and localization 三维空间中的空间注意力：目标检测和定位中近距离优势的元分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-29 DOI: 10.1016/j.neubiorev.2024.105869

{"title":"Spatial attention in three-dimensional space: A meta-analysis for the near advantage in target detection and localization","authors":"","doi":"10.1016/j.neubiorev.2024.105869","DOIUrl":"10.1016/j.neubiorev.2024.105869","url":null,"abstract":"<div><p>Studies have explored how human spatial attention appears allocated in three-dimensional (3D) space. It has been demonstrated that target distance from the viewer can modulate performance in target detection and localization tasks: reaction times are shorter when targets appear nearer to the observer compared to farther distances (i.e., near advantage). Times have reached to quantitatively analyze this literature. In the current meta-analysis, 29 studies (n = 1260 participants) examined target detection and localization across 3-D space. Moderator analyses included: detection vs localization tasks, spatial cueing vs uncued tasks, control of retinal size across depth, central vs peripheral targets, real-space vs stereoscopic vs monocular depth environments, and inclusion of in-trial motion. The analyses revealed a near advantage for spatial attention that was affected by the moderating variables of controlling for retinal size across depth, the use of spatial cueing tasks, and the inclusion of in-trial motion. Overall, these results provide an up-to-date quantification of the effect of depth and provide insight into methodological differences in evaluating spatial attention.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003385/pdfft?md5=66e6d1044a63a76e5debf26d1ad2c0df&pid=1-s2.0-S0149763424003385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics 脂滴在神经退行性疾病中的作用：从发病机制到治疗方法

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-27 DOI: 10.1016/j.neubiorev.2024.105867

{"title":"Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics","authors":"","doi":"10.1016/j.neubiorev.2024.105867","DOIUrl":"10.1016/j.neubiorev.2024.105867","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDDs) are a series of disorders characterized by the progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs affect millions of patients worldwide but lack effective treatments. Dysregulation of lipids, particularly the accumulation of lipid droplets (LDs), is strongly implicated in the pathogenesis of NDDs. How LDs contribute to the occurrence and development of NDDs, and their potential as therapeutic targets remain to be addressed. In present review, we first introduce the processes of LDs formation, transportation and degradation. We then highlight how the accumulation of LDs contributes to the pathogenesis of NDDs in a cell type-specific manner. Moreover, we discuss currently available methods for detecting LDs and elaborate on LDs-based therapeutic strategies for NDDs. Lastly, we identify gaps that need to be filled to better leverage LD-based theranostics in NDDs and other diseases. We hope this review could shed light on the role of LDs in NDDs and facilitate the development of novel therapeutic strategies for NDDs.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003361/pdfft?md5=2beb34dd61d451f214d9079f652bc67b&pid=1-s2.0-S0149763424003361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time fMRI-based neurofeedback to restore brain function in substance use disorders: A systematic review of the literature 基于实时 fMRI 的神经反馈，用于恢复药物使用障碍患者的大脑功能：文献系统回顾。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-27 DOI: 10.1016/j.neubiorev.2024.105865

{"title":"Real-time fMRI-based neurofeedback to restore brain function in substance use disorders: A systematic review of the literature","authors":"","doi":"10.1016/j.neubiorev.2024.105865","DOIUrl":"10.1016/j.neubiorev.2024.105865","url":null,"abstract":"<div><h3>Introduction</h3><p>Real-time functional magnetic resonance based-neurofeedback (fMRI-neurofeedback) is a neuromodulation tool where individuals self-modulate brain function based on real-time feedback of their brain activity. fMRI-neurofeedback has been used to target brain dysfunction in substance use disorders (SUDs) and to reduce craving, but a systematic synthesis of up-to-date literature is lacking.</p></div><div><h3>Method</h3><p>Following PRISMA guidelines, we conducted a systematic review of all the literature that examined the effects of fMRI-neurofeedback on individuals with regular psychoactive substance use (PROSPERO pre-registration = CRD42023401137).</p></div><div><h3>Results</h3><p>The literature included 16 studies comprising 446 participants with SUDs involving alcohol, tobacco, and cocaine. There is consistent <em>between-condition</em> (e.g., fMRI-neurofeedback versus control), less consistent <em>pre-to-post</em> fMRI-neurofeedback, and little <em>intervention-by-time</em> effects on brain function in prefrontal-striatal regions and craving.</p></div><div><h3>Conclusion</h3><p>The evidence for changes in brain function/craving was early and inconsistent. More rigorous experiments including repeated measure designs with placebo control conditions, are required to confirm the efficacy of fMRI-neurofeedback in reducing brain alterations and craving in SUDs.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003348/pdfft?md5=834f476923b080e12c674981a79a33a1&pid=1-s2.0-S0149763424003348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulation and meditation: A review and synthesis toward promoting well-being and understanding consciousness and brain 神经调节与冥想：回顾与综述：促进福祉，了解意识与大脑。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-24 DOI: 10.1016/j.neubiorev.2024.105862

{"title":"Neuromodulation and meditation: A review and synthesis toward promoting well-being and understanding consciousness and brain","authors":"","doi":"10.1016/j.neubiorev.2024.105862","DOIUrl":"10.1016/j.neubiorev.2024.105862","url":null,"abstract":"<div><p>The neuroscience of meditation is providing insight into meditation’s beneficial effects on well-being and informing understanding of consciousness. However, further research is needed to explicate mechanisms linking brain activity and meditation. Non-invasive brain stimulation (NIBS) presents a promising approach for causally investigating neural mechanisms of meditation. Prior NIBS-meditation research has predominantly targeted frontal and parietal cortices suggesting that it might be possible to boost the behavioral and neural effects of meditation with NIBS. Moreover, NIBS has revealed distinct neural signatures in long-term meditators. Nonetheless, methodological variations in NIBS-meditation research contributes to challenges for definitive interpretation of previous results. Future NIBS studies should further investigate core substrates of meditation, including specific brain networks and oscillations, and causal neural mechanisms of advanced meditation. Overall, NIBS-meditation research holds promise for enhancing meditation-based interventions in support of well-being and resilience in both non-clinical and clinical populations, and for uncovering the brain-mind mechanisms of meditation and consciousness.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003312/pdfft?md5=34ab1e9fafeda5a5689aa27a259a72da&pid=1-s2.0-S0149763424003312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A meta-analysis on the neuropsychological correlates of Borderline Personality Disorder: An update 关于边缘型人格障碍神经心理学相关因素的荟萃分析：最新进展。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-22 DOI: 10.1016/j.neubiorev.2024.105860

{"title":"A meta-analysis on the neuropsychological correlates of Borderline Personality Disorder: An update","authors":"","doi":"10.1016/j.neubiorev.2024.105860","DOIUrl":"10.1016/j.neubiorev.2024.105860","url":null,"abstract":"<div><p>Previous research on Borderline Personality Disorder (BPD) demonstrated dysfunction across a broad range of cognitive domains. However, the limited number of neuropsychological studies on BPD and their occasionally conflicting results have precluded a clear characterization of the neuropsychological features associated with this personality disorder. Therefore, the main aim of the present study is to provide an updated overview of neuropsychological functions related to BPD. A meta-analysis of 36 studies was performed, comparing the performance of BPD patients and healthy controls (HCs) across several cognitive domains. Significant differences between BPD patients and HCs in multiple cognitive domains were found. The smallest effect size was observed for general executive function, while the largest effect sizes were found in the long-term spatial memory and inhibition domains. In conclusion, the neuropsychological profile of BPD, characterized by deficits in inhibition as well as attention, memory, and executive functions, can result in difficulties in performing everyday activities. Accordingly, assessing neuropsychological functions could assist clinicians in developing more targeted non-pharmacological treatments.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003294/pdfft?md5=b8c054fa89ab83c1474847a2a31af5fb&pid=1-s2.0-S0149763424003294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harmony of Wnt pathway in Alzheimer's: Navigating the multidimensional progression from preclinical to clinical stages 阿尔茨海默氏症中 Wnt 通路的和谐：驾驭从临床前到临床阶段的多维进展。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-22 DOI: 10.1016/j.neubiorev.2024.105863

{"title":"Harmony of Wnt pathway in Alzheimer's: Navigating the multidimensional progression from preclinical to clinical stages","authors":"","doi":"10.1016/j.neubiorev.2024.105863","DOIUrl":"10.1016/j.neubiorev.2024.105863","url":null,"abstract":"<div><p>The Wnt pathway stands out as a pivotal signal transduction pathway, operating through two distinct modes of signaling: the canonical/β-catenin pathway and the non-canonical pathway. Among these, the canonical pathway assumes a paramount role in various physiological and pathological processes within the human body. Particularly in the brain, Wnt exhibits involvement in fundamental physiological events including neuronal differentiation/survival, axonogenesis, neural stem cell regulation, synaptic plasticity, and cell cycle modulation. Notably, scientific evidence underscores the critical role of the Wnt pathway in the pathogenesis of Alzheimer's disease (AD), correlating with its involvement in key pathological features such as tau tangles, Amyloid-β plaques, synaptic dysfunction, oxidative stress, mitochondrial dysfunction, cognitive impairments, and disruption of the blood-brain barrier integrity. This review aims to comprehensively explore the involvement and significance of Wnt signaling in Alzheimer's. Furthermore, it delves into recent advancements in research on Wnt signaling, spanning from preclinical investigations to clinical trials.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the neurobiology of social behavior through exploring brain-wide dynamics of neural activity 通过探索全脑神经活动动态，了解社会行为的神经生物学。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-17 DOI: 10.1016/j.neubiorev.2024.105856

{"title":"Understanding the neurobiology of social behavior through exploring brain-wide dynamics of neural activity","authors":"","doi":"10.1016/j.neubiorev.2024.105856","DOIUrl":"10.1016/j.neubiorev.2024.105856","url":null,"abstract":"<div><p>Social behavior is highly complex and adaptable. It can be divided into multiple temporal stages: detection, approach, and consummatory behavior. Each stage can be further divided into several cognitive and behavioral processes, such as perceiving social cues, evaluating the social and non-social contexts, and recognizing the internal/emotional state of others. Recent studies have identified numerous brain-wide circuits implicated in social behavior and suggested the existence of partially overlapping functional brain networks underlying various types of social and non-social behavior. However, understanding the brain-wide dynamics underlying social behavior remains challenging, and several brain-scale dynamics (macro-, meso-, and micro-scale levels) need to be integrated. Here, we suggest leveraging new tools and concepts to explore social brain networks and integrate those different levels. These include studying the expression of immediate-early genes throughout the entire brain to impartially define the structure of the neuronal networks involved in a given social behavior. Then, network dynamics could be investigated using electrode arrays or multi-channel fiber photometry. Finally, tools like high-density silicon probes and miniscopes can probe neural activity in specific areas and across neuronal populations at the single-cell level.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience 全球难民危机的社会心理和神经生物学方面：从脆弱性到复原力。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2024-08-17 DOI: 10.1016/j.neubiorev.2024.105859

{"title":"Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience","authors":"","doi":"10.1016/j.neubiorev.2024.105859","DOIUrl":"10.1016/j.neubiorev.2024.105859","url":null,"abstract":"<div><p>Anisman, H., Doubad, D., Asokumar, A. & Matheson, K. Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience. NEUROSCI BIOBEHAV REV, XXXX. Immigration occurs between countries either to obtain employment, for family reunification or to escape violence and other life-threatening conditions. Refugees and asylum seekers are often obligated to overcome a uniquely challenging set of circumstances prior to and during migration. Settlement following immigration may pose yet another set of stressors related to acculturation to the host country, as well as financial insecurity, discrimination, language barriers, and social isolation. Here we discuss the multiple consequences of immigration experiences, focusing on the health disturbances that frequently develop in adults and children. Aside from the psychosocial influences, immigration-related challenges may cause hormonal, inflammatory immune, and microbiota changes that favor psychological and physical illnesses. Some biological alterations are subject to modification by epigenetic changes, which have implications for intergenerational trauma transmission, as might disruptions in parenting behaviors and family dysfunction. Despite the hardships experienced, many immigrants and their families exhibit positive psychological adjustment after resettlement. We provide information to diminish the impacts associated with immigration and offer strength-based approaches that may foster resilience.</p></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0149763424003282/pdfft?md5=da5c5c33ce22dd6847cff1300877f653&pid=1-s2.0-S0149763424003282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0