{"title":"A mixed methods systematic review of assistance dogs for people with autism","authors":"Melissa Mulraney , Orlando Rincones , Chloe Bryant , Dimitrios Saredakis , Erica Ghezzi , Amit Lampit","doi":"10.1016/j.neubiorev.2025.106160","DOIUrl":"10.1016/j.neubiorev.2025.106160","url":null,"abstract":"<div><h3>Objectives</h3><div>To critically examine and synthesise the available evidence regarding the impact of assistance dogs on individuals with autism.</div></div><div><h3>Study design</h3><div>Mixed methods systematic review with meta-analysis of quantitative data and meta-aggregation of qualitative data. Studies were eligible for inclusion if they included participants with autism and data describing the impact, effectiveness, or participant experience with an assistance dog or a companion dog.</div></div><div><h3>Data sources</h3><div>CENTRAL, Embase, MEDLINE, and PsycINFO.</div></div><div><h3>Data synthesis</h3><div>Fourteen studies (one randomised controlled trial, three cohort, seven cross-sectional, and three single-arm studies) were included in the meta-analysis and 13 studies (eight cross-sectional, three longitudinal, and two case studies) were included in the meta-aggregation. There was some quantitative evidence that assistance dogs may be associated with benefit, but the pooled effect sizes are similar to those associated with companion dogs. The qualitative data suggested that parents perceived a broad range of benefits of assistance dogs but may be unprepared for the challenges associated with owning an assistance dog.</div></div><div><h3>Conclusion</h3><div>There is a lack of compelling evidence to suggest that assistance dogs confer unique benefits for individuals with autism. The evidence base is limited and of poor quality thus the potential benefits identified need to be interpreted with caution. Interpreting the quantitative and qualitative studies together, the findings indicate many potential benefits of assistance dogs for people with autism could be achieved by a companion dog.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106160"},"PeriodicalIF":7.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measuring interoception from infancy to childhood: A scoping review","authors":"Margaret Addabbo , Luca Milani","doi":"10.1016/j.neubiorev.2025.106161","DOIUrl":"10.1016/j.neubiorev.2025.106161","url":null,"abstract":"<div><h3>Background</h3><div>Interoception is the ability to perceive, understand, and respond to internal bodily signals. Despite its importance, our knowledge of interoceptive abilities in the early stages of development remains limited. Delays or atypical patterns in interoceptive development may serve as early indicators of potential developmental psychopathology. Thus, assessing interoception in infancy and early childhood is essential for advancing our understanding of both typical and atypical developmental pathways.</div></div><div><h3>Objective</h3><div>This scoping review summarises existing evidence regarding interoception from infancy to childhood and identifies the most common methods for assessing interoception in neurotypical pediatric populations.</div></div><div><h3>Design</h3><div>A literature review was performed through a robust search of three scientific databases.</div></div><div><h3>Results</h3><div>Among 663 studies, 24 articles met the inclusion criteria. The most commonly used methods in infancy were looking-time paradigms and brain-based implicit measures, such as Heart-Evoked Potentials (HEP). Researchers predominantly used child-adapted versions of Heart Tracking Tasks (HTT) for preschool-aged children. The primary methods for investigating interoceptive abilities among school-aged children included HTTs and self-report measures. Only one study used fMRI to examine mind-body connections in childhood, while two relied on parent reports.</div></div><div><h3>Conclusions</h3><div>This review offers a comprehensive overview of past and current methods for measuring interoception in the literature. It highlights the strengths and limitations of existing methodologies and presents recommendations to enhance our understanding of interoception in early human development.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106161"},"PeriodicalIF":7.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shakila Meshkat , Gunjan Malik , Richard J. Zeifman , Jennifer Swainson , Krishna Balachandra , Amy C. Reichelt , Yanbo Zhang , Lisa Burback , Olga Winkler , Andrew Greenshaw , Eric Vermetten , Leah M. Mayo , Robert Tanguay , Rakesh Jetly , Venkat Bhat
{"title":"Efficacy and safety of psilocybin for the treatment of substance use disorders: A systematic review","authors":"Shakila Meshkat , Gunjan Malik , Richard J. Zeifman , Jennifer Swainson , Krishna Balachandra , Amy C. Reichelt , Yanbo Zhang , Lisa Burback , Olga Winkler , Andrew Greenshaw , Eric Vermetten , Leah M. Mayo , Robert Tanguay , Rakesh Jetly , Venkat Bhat","doi":"10.1016/j.neubiorev.2025.106163","DOIUrl":"10.1016/j.neubiorev.2025.106163","url":null,"abstract":"<div><div>Psilocybin, a serotonergic psychedelic, may have therapeutic benefits for Substance Use Disorders (SUDs), but its overall efficacy and safety remain uncertain. This systematic review assessed the safety and efficacy of psilocybin for SUDs through a systematic database search conducted via OVID on May 22, 2024, and summarized 26 ongoing clinical trials registered on clinicaltrials.gov. Among 16 published included studies, 7 (43.75 %) focused on Alcohol Use Disorder (AUD), 5 (31.25 %) on Tobacco Use Disorder (TUD), and the remainder on Cocaine Use Disorder (CUD) (1, 6.25 %), Opioid Use Disorder (1, 6.25 %), Nicotine Use Disorder (1, 6.25 %), and multiple SUDs (1, 6.25 %). Study designs included open-label trials (5, 31.25 %), cross-sectional observational studies (6, 37.5 %), qualitative analyses (2, 12.5 %), one double-blind RCT (6.25 %), one pilot fMRI study (6.25 %), and one long-term follow-up (6.25 %). Psilocybin-assisted psychotherapy (PAP) was used in 10 studies (62.5 %), with doses ranging from microdosing to 20–40 mg/70 kg. PAP was associated with significant reductions in alcohol consumption, smoking cessation, and related psychological improvements. AUD studies reported fewer heavy drinking days, increased abstinence rates, and neuroimaging data indicating normalization of brain activity. TUD studies demonstrated high smoking abstinence rates, with mystical experiences predicting long-term outcomes. Findings for other SUDs were mixed, though psilocybin showed potential in reducing opioid dependence and nicotine use. Preliminary evidence supports psilocybin’s efficacy and safety for AUD and TUD, particularly with psychotherapy, but larger clinical trials are needed to confirm these findings.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106163"},"PeriodicalIF":7.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander J. Cook , Hee Yeon Im , Deborah E. Giaschi
{"title":"Large-scale functional networks underlying visual attention","authors":"Alexander J. Cook , Hee Yeon Im , Deborah E. Giaschi","doi":"10.1016/j.neubiorev.2025.106165","DOIUrl":"10.1016/j.neubiorev.2025.106165","url":null,"abstract":"<div><div>Attention networks are loosely defined as the regions of the brain which interact to control behaviour during attentional tasks, but the specific definition of attention networks varies between research programs based on task demands and modalities. The Attention Network Task was designed to exemplify three aspects of attention, alerting, orienting, and executive control, using a visual cueing paradigm. Its proponents propose a system of networks which underlies these aspects. It is debated whether there exists a unified system of networks which underlies attention independently of other cognitive and sensory processing systems. We review the evidence for an attention system within the domain of visual attention. Neuroimaging research using fMRI, EEG, MEG, and others across a variety of tasks attributed to attention, visual cueing, visual search, and divided attention, is compared. This concludes with a discussion on the limitations of an independent “attention system” for describing how the brain flexibly controls many abilities attributed to visual attention.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106165"},"PeriodicalIF":7.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Nasir , Maryam Afridi , Ome Kalsoom Afridi , Muhammad Arif Khan , Amir Khan , Jun Zhang , Bai Qian
{"title":"The persistent pain enigma: Molecular drivers behind acute-to-chronic transition","authors":"Abdul Nasir , Maryam Afridi , Ome Kalsoom Afridi , Muhammad Arif Khan , Amir Khan , Jun Zhang , Bai Qian","doi":"10.1016/j.neubiorev.2025.106162","DOIUrl":"10.1016/j.neubiorev.2025.106162","url":null,"abstract":"<div><div>The transition from acute to chronic pain is a complex and multifactorial process that presents significant challenges in both diagnosis and treatment. Key mechanisms of peripheral and central sensitization, neuroinflammation, and altered synaptic plasticity contribute to the amplification of pain signals and the persistence of pain. Glial cell activation, particularly microglia and astrocytes, is pivotal in developing chronic pain by releasing pro-inflammatory cytokines that enhance pain sensitivity. This review explores the molecular, cellular, and systemic mechanisms underlying the transition from acute to chronic pain, offering new insights into the molecular and neurobiological mechanisms involved, which are often underexplored in existing literature. It also addresses emerging therapeutic strategies beyond traditional pain management, offering valuable perspectives for future research and clinical applications.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106162"},"PeriodicalIF":7.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Tröger , Pietro Carmellini , Dimosthenis Tsapekos , Joachim Gross , Allan H. Young , Rebecca Strawbridge , Philipp Ritter
{"title":"EEG markers of cognitive performance in bipolar disorder – A systematic review","authors":"Anna Tröger , Pietro Carmellini , Dimosthenis Tsapekos , Joachim Gross , Allan H. Young , Rebecca Strawbridge , Philipp Ritter","doi":"10.1016/j.neubiorev.2025.106157","DOIUrl":"10.1016/j.neubiorev.2025.106157","url":null,"abstract":"<div><h3>Background</h3><div>People with bipolar disorder (BD) may experience impairing cognitive deficits, even in remission. Electroencephalographic (EEG) measures can depict neurophysiological activity with high temporal resolution. They could therefore be an adequate method to pinpoint the cognitive impairments in BD, facilitating understanding of when exactly the cognitive processing is disrupted and what neurophysiological systems are involved. In the absence of a previous literature examination, this systematic review aimed to synthesize the evidence of associations between EEG and cognitive measures to identify electrophysiological markers of cognitive performance in BD.</div></div><div><h3>Methods</h3><div>A systematic search across PubMed, EMBASE, APA PsycInfo and Cochrane Library until November 2023 was undertaken to identify studies in which a direct correlation between any continuous EEG measure and any continuous cognitive measure in participants with BD was reported. A narrative synthesis approach was used to present the identified correlations, across five cognitive (attention and processing speed, working memory, episodic memory, executive function, and intellectual capacity) and four EEG domains (event-related potentials (ERP), spectral, connectivity and other measures).</div></div><div><h3>Results</h3><div>A total of 16 articles describing 15 studies were included in the review. Six studies identified significant correlations. Most significant correlations were reported between ERP measures and attention and processing speed performance, several between ERP measures and executive functioning and one within the working memory and the intellectual capacity domain respectively. However, most of the identified significant correlations were conflicting within (different measures or mood states) and across studies with no consistent significant correlation across studies. The majority of identified correlations were non-significant.</div></div><div><h3>Conclusions</h3><div>As yet no robust EEG markers of cognitive performance in people with BD are known. This review highlights the heterogeneity in measures and participant characteristics between studies and the need for standardization. Further studies with homogeneous methods and participant groups may help to establish consistent associations.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106157"},"PeriodicalIF":7.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Lo Presti , M. Bonavita , V. Piga , S. Lozito , F. Doricchi , S. Lasaponara
{"title":"\"Don’t stop believing” - Decoding belief dynamics in the brain: An ALE meta-analysis of neural correlates in belief formation and updating","authors":"S. Lo Presti , M. Bonavita , V. Piga , S. Lozito , F. Doricchi , S. Lasaponara","doi":"10.1016/j.neubiorev.2025.106153","DOIUrl":"10.1016/j.neubiorev.2025.106153","url":null,"abstract":"<div><div>Understanding how individuals form and update their beliefs is a fundamental question in cognitive and social psychology. Belief formation (BF) refers to the initial development of an individual's belief, while belief updating (BU) pertains to the revision of existing beliefs in response to contradictory evidence. Although these two processes are often interwoven, they might operate through different neural mechanisms. This meta-analysis aims to synthesize the existing functional magnetic resonance imaging (fMRI) literature on BF and BU, with a particular focus on how BF is investigated. Approaches based on Theory of Mind paradigms, such as False Belief tasks, are often opposed to other approaches, emphasizing the role of individual or situational factors in belief formation. Notably, we propose that this differentiation might reflect the engagement of social and non-social dynamics within belief formation. Activation likelihood estimation (ALE) analysis revealed shared involvement of the Precuneus (PCu) in both BF and BU, while BF specifically engaged the bilateral activation of the Temporo-Parietal Junctions (TPJ). Additionally, social and non-social BF exhibited distinct neural correlates: social BF was associated with activity in the right TPJ, whereas non-social BF relied on the left dorsolateral prefrontal cortex (DLPFC). These findings support the hypothesis that BF and BU operate via partially dissociable neural networks and highlights the role of TPJ and PCu as essential hubs to build-up neural templates and enabling shifts in viewpoint necessary to adapt beliefs.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106153"},"PeriodicalIF":7.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simone Rehn , Joel S. Raymond , Robert A. Boakes , Michael D. Kendig , Cathalijn H.C. Leenaars
{"title":"Behavioural and physiological effects of binge eating: a systematic review and meta-analysis of animal models","authors":"Simone Rehn , Joel S. Raymond , Robert A. Boakes , Michael D. Kendig , Cathalijn H.C. Leenaars","doi":"10.1016/j.neubiorev.2025.106135","DOIUrl":"10.1016/j.neubiorev.2025.106135","url":null,"abstract":"<div><div>Binge eating is defined as eating abnormally large amounts in a brief period of time. Many animal studies have examined the behavioural and physiological effects of binge eating of high-fat, high-sugar foods to model the consequences of human binge eating. The present systematic review of 199 rodent studies sought to identify the behavioural and physiological consequences of binge eating and determine whether changes were specific to binge eating or to general effects of exposure to a palatable diet. A meta-analysis of 18 rodent studies revealed that binge eating produces greater anxiety-like behaviour on the Elevated Plus-Maze with a small effect size and significant funnel plot asymmetry, suggesting that the true effect size is overestimated. A history of binge-like access generally increases progressive ratio breakpoint for the binged food, without altering 'liking' as measured by lick microstructure, suggesting that dissociable effects on ‘wanting’ but not ‘liking’ accompany binge eating behaviour and contribute to its persistence. Binge eating appears to enhance compulsive food-seeking behaviour and prevent stress-induced reductions in intake but does not appear to alter depression-like behaviour or locomotor activity. Notably, binge eating may produce comparable metabolic impairments to those observed after extended continuous exposure to a palatable diet despite no overall effects on body weight outcomes in most studies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106135"},"PeriodicalIF":7.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maarten Laroy , Louise Emsell , Mathieu Vandenbulcke , Filip Bouckaert
{"title":"Mapping electroconvulsive therapy induced neuroplasticity: Towards a multilevel understanding of the available clinical literature – A scoping review","authors":"Maarten Laroy , Louise Emsell , Mathieu Vandenbulcke , Filip Bouckaert","doi":"10.1016/j.neubiorev.2025.106143","DOIUrl":"10.1016/j.neubiorev.2025.106143","url":null,"abstract":"<div><div>Since its introduction in 1938, the precise mechanism underlying the efficacy of electroconvulsive therapy (ECT) in treating severe psychiatric disorders remains elusive. This paper presents a comprehensive scoping review aimed to collate and summarize findings from clinical studies on neuroplastic changes induced by ECT. The review categorizes neuroplasticity into molecular, structural, and functional domains, offering a multilevel view of current research and its limitations. Molecular findings detail the varied responses of neurotrophic factors and neurotransmitters post-ECT, highlighting inconsistent evidence on their clinical relevance. Structural neuroplasticity is explored through changes in brain volume, cortical thickness, and white matter properties, presenting ECT as a potent stimulator of brain architecture alterations. Functional plasticity examines ECT's impact on brain function through diverse neuroimaging techniques, suggesting significant yet complex modifications in brain network connectivity and activity. The review emphasizes the multilevel nature of these neuroplasticity levels and their collective role in ECT's therapeutic outcomes. Methodological considerations—including sample size, patient heterogeneity, and variability in assessment timing—emerge as recurring themes in the literature, underscoring the need for more consistent and rigorous research designs. By outlining a cohesive framework of changes in neuroplasticity due to ECT, this review provides initial steps towards a deeper comprehension of ECT's mechanisms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106143"},"PeriodicalIF":7.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconceptualizing the relationship between anxiety, mindfulness, and cognitive control","authors":"Resh S. Gupta , Wendy Heller , Todd S. Braver","doi":"10.1016/j.neubiorev.2025.106146","DOIUrl":"10.1016/j.neubiorev.2025.106146","url":null,"abstract":"<div><div>Prior research has provided initial support for the claim that cognitive control mediates the relationship between anxiety and mindfulness; however, findings are often inconsistent. In this review, we argue that the inconsistency may be due to a lack of both conceptual and methodological precision in terms of how anxiety, cognitive control, and mindfulness are operationalized and assessed, and that this imprecision may be a critical source of study confounds and ambiguous outcomes. We unpack this argument by first decomposing anxiety, cognitive control, mindfulness, and relevant experimental paradigms into key dimensions in order to develop a non-unitary, multi-dimensional taxonomy of these constructs. Subsequently, we review and reinterpret the prior experimental literature, focusing on studies that examine the relationship between anxiety and cognitive control, mindfulness and cognitive control, and the three-way relationship between anxiety, mindfulness, and cognitive control. Across the reviewed studies, there was great variation in the dimensions being examined and the behavioral and/or neural measures employed; therefore, results were often mixed. Based on this review of literature, we propose a conceptually and methodologically precise framework from which to study the effects of mindfulness on cognitive control in anxiety. The framework theoretically aligns anxiety dimensions with specific mindfulness states and interventions, further suggesting how these will impact specific cognitive control dimensions (proactive, reactive). These can be assessed with experimental paradigms and associated behavioral and neural metrics to index the relevant dimensions with high precision. Novel experimental studies and tractable research designs are also proposed to rigorously test this theoretical framework.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106146"},"PeriodicalIF":7.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}