Neuroscience and Biobehavioral Reviews最新文献

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Classification of neurological and mental health disorders based on multimodal approaches: A comprehensive review 基于多模态方法的神经和精神健康障碍分类综述
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-04 DOI: 10.1016/j.neubiorev.2025.106399
Hivi I. Dino , Masoud M. Hassan
{"title":"Classification of neurological and mental health disorders based on multimodal approaches: A comprehensive review","authors":"Hivi I. Dino ,&nbsp;Masoud M. Hassan","doi":"10.1016/j.neubiorev.2025.106399","DOIUrl":"10.1016/j.neubiorev.2025.106399","url":null,"abstract":"<div><div>Disorders of the nervous system and mental health are among the most prevalent, complex, and devastating health challenges globally, with a significant<!--> <!-->impact on quality of life. Recently, advances in deep learning-based multimodal methodologies have transformed the classification<!--> <!-->and detection of these disorders through the utilization of diverse data types including neuroimaging, bio-signals, and clinical evaluations. These multimodal techniques provide a more holistic understanding of complex conditions, addressing the limitations of traditional unimodal methods, which often fail to capture the multifaceted nature of these disorders. Despite the growing body of research, a comprehensive review focusing on the application of deep learning-based multimodal approaches to both neurological and mental health disorders remains lacking. This review fills this gap by offering an in-depth analysis of recent advancements in machine learning and deep learning-based multimodal classification for ten major disorders: five neurological and five mental health-related. It examined key modalities, explored fusion strategies, and provided insights into the strengths and weaknesses of existing multimodal approaches. Additionally, this review highlighted the challenges associated with multimodal data integration, such as data imbalance, model interpretability, and the need for large-scale, high-quality datasets. Furthermore, the review discussed emerging trends and future directions, emphasizing the potential of advanced fusion and computational techniques to enhance the clinical applicability of these models. By synthesizing the current state of research, this review aims to guide future studies and contribute to the development of more accurate, reliable, and accessible diagnostic tools for neurological and mental health disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"179 ","pages":"Article 106399"},"PeriodicalIF":7.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of eye-tracking to find objective outcome measures of early intervention strategies for children with autism: a systematic review. 使用眼动追踪寻找自闭症儿童早期干预策略的客观结果测量:系统回顾。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-04 DOI: 10.1016/j.neubiorev.2025.106391
Chloé Peter, Maria-Paraskevi Antoniou, Evelyne Antonietti, Joana Almeida Osório, Joëlle Rosselet Amoussou, Nadia Chabane, Borja Rodríguez-Herreros
{"title":"The use of eye-tracking to find objective outcome measures of early intervention strategies for children with autism: a systematic review.","authors":"Chloé Peter, Maria-Paraskevi Antoniou, Evelyne Antonietti, Joana Almeida Osório, Joëlle Rosselet Amoussou, Nadia Chabane, Borja Rodríguez-Herreros","doi":"10.1016/j.neubiorev.2025.106391","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106391","url":null,"abstract":"<p><strong>Objective: </strong>Early intervention strategies are recommended for children with autism to improve cognitive and social communication skills. However, there is a persistent challenge to identify objective outcome measures of intervention efficacy. Eye-tracking (ET) is a safe and well-tolerated technology able to detect differences in visual attention through gaze behavior. This systematic review aims to identify, appraise and summarize the existing literature using ET to track response to early intervention in autism clinical trials.</p><p><strong>Method: </strong>A comprehensive literature search was conducted in December 2024 in several bibliographic databases, including Medline ALL Ovid, Embase.com, APA PsycInfo Ovid, the Cochrane Library Wiley and PubMed Central. Additionally, we searched trial registries and we performed citation tracking strategies. We retained randomized controlled trials (RCTs) incorporating an ET outcome measure to evaluate the effect of direct, parent-mediated and pharmacological early interventions. Quality was assessed using Risk of Bias 2 and GRADE.</p><p><strong>Results: </strong>Out of 1'726 reports screened, eleven articles from nine unique studies met inclusion criteria, with overall low-to-moderate risk of bias. Six out of the nine intervention approaches showed improvements in several indices of visual attention measured with different ET paradigms. We also identified 24 RCTs registered with an ET outcome measure yet without published results.</p><p><strong>Conclusion: </strong>ET proved to be a clinically relevant measure sensitive to change in several interventional contexts. However, not all ET paradigms measured change over time reliably, compromising interpretability. Further research is needed to ensure that ET potentially becomes an accessible and accurate tool for widespread adoption in clinical practice.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106391"},"PeriodicalIF":7.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging mechanistic heterogeneity and goal-directed regulation in substance use disorders: Commentary on Guerrin et al. (2025) 弥合物质使用障碍的机制异质性和目标导向调节:对Guerrin等人的评论(2025)。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-04 DOI: 10.1016/j.neubiorev.2025.106394
Xavier Noël
{"title":"Bridging mechanistic heterogeneity and goal-directed regulation in substance use disorders: Commentary on Guerrin et al. (2025)","authors":"Xavier Noël","doi":"10.1016/j.neubiorev.2025.106394","DOIUrl":"10.1016/j.neubiorev.2025.106394","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106394"},"PeriodicalIF":7.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A NEUROECOLOGICAL PERSPECTIVE ON THE PREFRONTAL CORTEX. 前额皮质的神经生态学观点。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-04 DOI: 10.1016/j.neubiorev.2025.106400
Rogier B Mars, Richard E Passingham
{"title":"A NEUROECOLOGICAL PERSPECTIVE ON THE PREFRONTAL CORTEX.","authors":"Rogier B Mars, Richard E Passingham","doi":"10.1016/j.neubiorev.2025.106400","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106400","url":null,"abstract":"<p><p>The anthropoids, that is monkeys, apes and humans, are highly adaptable. This enhanced adaptability depends on the development of new areas in the prefrontal cortex. In the human brain these regions support reasoning and decision-making. We need to explain how the prefrontal regions of our ancestors were co-opted to allow this. We take up this challenge by adopting a neuroecological perspective. We take advantage of three lines of evidence: evolutionary biology elucidating the foraging niches of early anthropoid primates; comparative neuroscience comparing the human brain with that of other living primates; and computational neuroscience detailing the computations underlying free-ranging behaviour. We demonstrate that the enhanced adaptability of anthropoids depends on their ability to understand abstract concepts such as number, order, and identity. The selective advantage is that when foraging they can solve problems rapidly if they have an abstract similarity to ones they have met previously. We show which prefrontal areas are homologous in humans and monkeys. Though the human prefrontal cortex is especially expanded, it has the same fundamental organisation as in macaques. We conclude that, through our common ancestry, humans have co-opted the abilities that macaques use for foraging to support reasoning and decision-making.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106400"},"PeriodicalIF":7.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeys lack humanlike behavioral and neural inversion costs in face identity recognition 猴子在人脸识别方面缺乏人类的行为和神经反转成本。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-03 DOI: 10.1016/j.neubiorev.2025.106397
Bruno Rossion
{"title":"Monkeys lack humanlike behavioral and neural inversion costs in face identity recognition","authors":"Bruno Rossion","doi":"10.1016/j.neubiorev.2025.106397","DOIUrl":"10.1016/j.neubiorev.2025.106397","url":null,"abstract":"<div><div>There is long-standing confusion in the scientific literature as to whether macaque monkeys show, like humans, a large decrease of performance for recognizing the identity of faces presented upside-down. Clarifying this issue is important because performance decrease for inverted faces is a hallmark of our species’ expertise at face identity recognition (FIR), and the macaque monkey is widely considered as the reference animal model to clarify the neural mechanisms of this function. Here I report a theoretically-oriented critical review of behavioral and neural studies regularly cited as having tested the effect of inversion on FIR in macaque monkeys. I show that the confusion originates essentially from studies in macaques showing a mere behavioral or neural preference for upright over inverted faces independently of identity recognition, or confounding effects of stimulus inversion with training and stimulation constancy. Considering studies that properly tested the effect of inversion on FIR makes it clear that there is no behavioral or neural cost of such stimulus manipulation in macaques. This conclusion is congruent with a wide source of neurofunctional evidence indicating that the macaque monkey is not a valid animal model for human face identity recognition.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"179 ","pages":"Article 106397"},"PeriodicalIF":7.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of mindfulness-based meditation on the immune function of breast cancer patients: A systematic review and three-level meta-analysis 正念冥想对乳腺癌患者免疫功能的影响:系统综述和三水平荟萃分析。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-02 DOI: 10.1016/j.neubiorev.2025.106396
Meng Yu , Yuchang Jin , Junxiu An , Peixuan Zheng
{"title":"The effect of mindfulness-based meditation on the immune function of breast cancer patients: A systematic review and three-level meta-analysis","authors":"Meng Yu ,&nbsp;Yuchang Jin ,&nbsp;Junxiu An ,&nbsp;Peixuan Zheng","doi":"10.1016/j.neubiorev.2025.106396","DOIUrl":"10.1016/j.neubiorev.2025.106396","url":null,"abstract":"<div><div>Mindfulness-based meditation has been proposed as a complementary approach to support immune function in cancer patients, yet its biological effects remain unclear and heterogeneous across biomarkers. This study systematically reviewed and quantitatively synthesized empirical evidence using a three-level random-effects meta-analysis to account for statistical dependence among multiple effect sizes. A systematic search through December 2024 identified 11 reports (9 unique studies) with 110 effect sizes (<em>N</em> = 991). Eligible studies involved cancer patients (primarily breast cancer, &gt;87 %) undergoing mindfulness-based meditation interventions and reporting immune-related biomarkers. Hedges’ g was used to calculate effect sizes. In the first-round analysis, based on RCT post-test data, mindfulness-based meditation showed a small but significant effect on immune function (<em>g</em> = 0.100, <em>p</em> = .026, 95 % <em>CI</em> [0.012, 0.188]). The second-round analysis, incorporating pre–post data from both RCTs and single-group studies, yielded a non-significant effect (<em>g</em> = 0.067, <em>p</em> = .114, 95 % <em>CI</em> [–0.016, 0.150]). Among tested moderators, only country significantly influenced effect sizes, whereas intervention duration, intervention type, and biomarker type did not. These findings suggest that mindfulness-based meditation may modestly regulate immune function in cancer patients by reducing inflammation, increasing immune cell counts and activity, and potentially promoting telomere length and activity. More rigorously designed studies with standardized biomarker reporting and more diverse populations are needed to clarify its therapeutic potential.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"179 ","pages":"Article 106396"},"PeriodicalIF":7.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How pain fools everyone: An inference to the best explanation. 痛苦如何愚弄所有人:一个最佳解释的推论。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106317
Brian Key, Deborah J Brown
{"title":"How pain fools everyone: An inference to the best explanation.","authors":"Brian Key, Deborah J Brown","doi":"10.1016/j.neubiorev.2025.106317","DOIUrl":"10.1016/j.neubiorev.2025.106317","url":null,"abstract":"<p><p>There is a commonly held assumption that feelings such as pain are causes of behaviour. We say we withdrew our hand from the hotplate because it hurt or that we flinched at the needle because it stung. The causal role of pain is widely implicated in theories of learning and decision-making. But what if this commonsense idea that feelings cause behaviour is just wrong? To date, there is no known mechanism for how subjectively experienced pain directly modulates neural activity and it is hard to see how there could be. There is no known mechanism by which pain could directly gate ion channels. On this basis, we contend that the real cause of behaviour is neural activity and that feelings of pain have no known causal role. This raises the question of whether pain has any function at all-i.e., whether it has causal powers or is merely epiphenomenal. Epiphenomenalism faces the intractable problem of explaining how such an attention-consuming feeling as pain could be epiphenomenal and yet still have survived evolutionary selection. In response, we infer from the available neuroscientific evidence that the best explanation is that pain has a novel, non-causal function and that decisions to act are instead caused by an internal decoding process involving threshold detection of accumulated evidence of pain rather than by pain per se. Because pain is necessarily implicated in the best explanation of subsequent decision-making, we do not conclude that pain is epiphenomenal or functionless even if it has no causal influence over decisions or subsequent actions. On this view, pain functions to mark neural pathways that are the causes of behaviour as salient, serving as a ground but not a cause of subsequent decision-making and action. This perspective has far-reaching implications for diverse fields including neuropsychiatry, biopsychosocial modelling, robotics, and brain-computer interfaces.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106317"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation manipulation and a complement-centered reboot of the Toxoplasma gondii model of schizophrenia. 炎症操纵和以补体为中心的刚地弓形虫精神分裂症模型的重启。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106313
Jianchun Xiao, Emily G Severance
{"title":"Inflammation manipulation and a complement-centered reboot of the Toxoplasma gondii model of schizophrenia.","authors":"Jianchun Xiao, Emily G Severance","doi":"10.1016/j.neubiorev.2025.106313","DOIUrl":"10.1016/j.neubiorev.2025.106313","url":null,"abstract":"<p><p>The protozoan parasite, Toxoplasma gondii, has evolved a creative skillset to engage and sustain itself within a diversity of warm-blooded hosts. Progression to adulthood requires residence in the definitive host, Felidae, a taxonomic family encompassing the beloved, sometimes maligned, housecat. Humans are intermediate hosts, primarily infected following ingestion of foodstuffs containing T. gondii tissue cysts or T. gondii oocysts shed by cats. Although most human cases are asymptomatic, acute inflammation and deadly encephalopathies can result if the infection is congenital, or the host is immunocompromised. Increasingly, presumably benign asymptomatic infections are being investigated for behavioral outcomes and complex brain disorders such as schizophrenia. While not typically considered an inflammatory disorder, reports of muted idiopathic inflammation-like comorbidities in schizophrenia persist and cannot be discounted by the usual covariants, medications and metabolic factors. T. gondii's survival success may depend on its ability to regulate host inflammation and satisfy its own life-stage requirements for both motility and quiescence. Within the setting of this fluctuating inflammatory environment putatively controlled by T. gondii, other gene and environmental forces are also at work. We consider a model of schizophrenia centered on complement gene variants and the unique capacity for this set of immune pathways to perpetrate and perpetuate neurobiological dysfunction. We examine T. gondii's connections to the gut, to chronic stress, how its relationship with schizophrenia has matured, and how the boundaries between what qualifies as gene and environment have become blurred as we enter a new era of the microbiome and more personalized medicine.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106313"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the motor system in action imagination and comprehension 运动系统在动作想象和理解中的作用
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-01 DOI: 10.1016/j.neubiorev.2025.106392
W. Dupont , C. Madden-Lombardi , M. Perrone-Bertolotti , R. Palluel-Germain , F. Lebon
{"title":"The role of the motor system in action imagination and comprehension","authors":"W. Dupont ,&nbsp;C. Madden-Lombardi ,&nbsp;M. Perrone-Bertolotti ,&nbsp;R. Palluel-Germain ,&nbsp;F. Lebon","doi":"10.1016/j.neubiorev.2025.106392","DOIUrl":"10.1016/j.neubiorev.2025.106392","url":null,"abstract":"<div><div>Covert actions encompass cognitive processes such as motor imagery, action observation, and action language. These processes ignite motor simulations within the mind and engage neural circuits underlying sensorimotor functions, offering promising potential for optimizing motor performance and rehabilitation strategies. Yet, despite broad consensus on the motor system’s involvement, its precise role — whether a dynamic embodiment mechanism or a mere epiphenomenon — remains a matter of intense debate. In this review, we present a comprehensive analysis of motor system engagement across motor imagery, action observation, and action language. First, we examine correlational evidence derived from functional magnetic resonance imaging and transcranial magnetic stimulation studies in healthy individuals, including those with impaired mental simulation abilities. This evidence helps elucidate whether, and to what extent, these cognitive processes recruit the motor system, particularly the primary motor cortex. We then turn to causal evidence, which allows us to infer the functional role of the motor system in these processes. Specifically, we review findings from studies investigating behavioral changes, patients with lesions, and artificial lesions in healthy participants created using neuromodulation techniques. By integrating these perspectives, we seek to clarify this ongoing debate by illuminating the functional role of the motor system in motor imagery, action observation, and action language.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106392"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the flexibility of working memory: Compositionality, generative processing, anchors and holistic representations 理解工作记忆的灵活性:组合性、生成处理、锚点和整体表征。
IF 7.9 1区 医学
Neuroscience and Biobehavioral Reviews Pub Date : 2025-10-01 DOI: 10.1016/j.neubiorev.2025.106387
Brad Wyble , Joyce Tam , Ian Deal , Howard Bowman
{"title":"Understanding the flexibility of working memory: Compositionality, generative processing, anchors and holistic representations","authors":"Brad Wyble ,&nbsp;Joyce Tam ,&nbsp;Ian Deal ,&nbsp;Howard Bowman","doi":"10.1016/j.neubiorev.2025.106387","DOIUrl":"10.1016/j.neubiorev.2025.106387","url":null,"abstract":"<div><div>The typical conception of working memory is a mechanism to temporarily hold multiple discrete objects in service of other cognitive tasks in an item-based representation. In this paper, we expand the conventional idea that working memory represents objects into a more flexible framework that uses compositional and generative mechanisms to code and then re-code visual input according to task demands. Compositionality allows complex scenes or objects to be mentally decomposed into constituents that can be individually manipulated or recombined to form new representations. Generative processing allows purely conceptual information to be reconstructed in a format akin to visual sensory representations that can be manipulated and re-processed by perceptual mechanisms. Together, compositional and generative mechanisms would enable a wide range of cognitive functions including the basis of visual imagery. In our view, working memory items do not need to correspond to discrete objects, but could serve as pointers or anchors to clusters of features that form parts of objects, or alternatively, multiple objects could be encoded as one holistic item depending on the task. We conclude with a conceptual account of such a memory system that can build and re-use information by moving it between different levels of abstraction within a perceptual hierarchy. This model is linked to experimental results from the memory and visual imagery literatures that illustrate the flexibility of such a system for performing cognitive tasks.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"179 ","pages":"Article 106387"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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