Neuroscience and Biobehavioral Reviews最新文献

{"title":"Selective attention and eccentricity: A comprehensive review","authors":"Christian N.L. Olivers","doi":"10.1016/j.neubiorev.2025.106368","DOIUrl":"10.1016/j.neubiorev.2025.106368","url":null,"abstract":"<div><div>Human vision deals with two major limitations. First, vision is strongly foveated and deteriorates with eccentricity. Second, visual attention selectively prioritizes some stimuli over others. I review the functional and neurophysiological links between attention and eccentricity across a range of protocols including spatial cueing, crowding, dual tasking, and visual search, for both spatial and feature-based attention. The main conclusions are: 1) Attention and eccentricity are intrinsically intertwined. Functionally, attention partially compensates for peripheral vision’s limits, effectively expanding the functional visual field. Neurophysiologically, attention appears tightly linked to receptive field properties across eccentricity and the visual hierarchy. 2) We must distinguish between attention as a mechanism and attention as an effect. Whereas its effects may vary, attention as a mechanism appears overall remarkably stable across eccentricity. 3) Eccentricity ranges have been severely limited. We know little about attention further into the periphery and findings beyond the effective oculomotor range have been ambiguous. 4) The spatial profile of the attentional distribution and how this is achieved remains to be determined, with evidence for gradients, Mexican hats, and rings. By default attention appears biased towards the center, but whether and in what way cognitive load aggravates this ‘tunnel vision’ remains unclear. 5) Research on feature-based attention as a function of eccentricity has been markedly underrepresented. The scarce findings suggest that it operates globally across the visual field, but to what extent it does so uniformly and how this changes the functional visual field remains unknown. Future empirical and modeling directions are suggested.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106368"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the insula in the Takotsubo Cardiomyopathy: A scoping review","authors":"Laura Catalano ,&nbsp;Laura Sagliano ,&nbsp;Alessia Salzillo ,&nbsp;Ekaterina Ivanova ,&nbsp;Maria Pennacchio ,&nbsp;Martina Mancano ,&nbsp;Costanza Papagno ,&nbsp;Luigi Trojano","doi":"10.1016/j.neubiorev.2025.106369","DOIUrl":"10.1016/j.neubiorev.2025.106369","url":null,"abstract":"<div><div>Takotsubo cardiomyopathy (TC) is a transient cardiomyopathy secondary to emotional and/or physical stress. While its precise aetiology remains unclear, some evidence suggests a possible role for the insular cortex (IC), which modulates cardiovascular responses to stress. The IC is a key viscerosensory and visceromotor hub with widespread connections, and is implicated in interoceptive processing, emotional regulation, and autonomic control. Considering the strong link between stress and TC, and the insula involvement in stress and autonomic regulation, this scoping review aimed at exploring the role of the IC in the onset and modulation of TC. To this end, we examined the evidence derived from both lesional and neuroimaging studies. The results showed that TC can be related to strokes involving the IC, and is associated with structural and functional IC alterations, particularly in the left hemisphere and in female patients. Neuroimaging studies revealed abnormal IC connectivity during stress induction and in resting-state in patients with TC. These findings support the hypothesis that IC dysfunction contributes to autonomic changes in TC, beyond the effects of stress alone.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106369"},"PeriodicalIF":7.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic changes and neurogenesis associated with socio-sexual behaviors","authors":"GD Rivera-Bautista ,&nbsp;DM Arzate ,&nbsp;D. Ávila-González ,&nbsp;AE Castro ,&nbsp;ER Vázquez-Martínez ,&nbsp;NF Díaz ,&nbsp;W. Portillo","doi":"10.1016/j.neubiorev.2025.106359","DOIUrl":"10.1016/j.neubiorev.2025.106359","url":null,"abstract":"<div><div>Epigenetic mechanisms are essential in neurogenesis during development and adulthood. DNA methylation, histone post-translational modifications, and non-coding RNAs regulate gene expression to maintain the neural stem cell pool and direct the fate of newborn neurons by modulating cell proliferation, migration, differentiation, maturation, and survival. Adult neurogenesis exhibits bidirectional interactions with non-social and socio-sexual factors such as sexual behavior, mate recognition, pair bonding, parental behavior, and offspring recognition. Epigenetic mechanism disruption has been implicated in metabolic diseases, cancer, and neurodegenerative disorders. Nevertheless, the precise role of these mechanisms in adult neurogenesis and their subsequent effects on behavior are not fully understood, particularly in the context of social interactions. This review examines emerging evidence that links epigenetic mechanisms and neurogenesis to the complex interplay between biological processes and socio-sexual behaviors, focusing specifically on socially monogamous prairie voles.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106359"},"PeriodicalIF":7.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroactive steroids role in mood disorders and PTSD","authors":"Rainer Rupprecht","doi":"10.1016/j.neubiorev.2025.106361","DOIUrl":"10.1016/j.neubiorev.2025.106361","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106361"},"PeriodicalIF":7.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Machine Learning predict therapeutic outcomes in affective and not affective psychosis? A systematic review and meta-analysis","authors":"Monopoli Camilla ,&nbsp;Colombo Federica ,&nbsp;Cazzella Tommaso ,&nbsp;Fortaner-Uyà Lidia ,&nbsp;Raffaelli Laura ,&nbsp;Calesella Federico ,&nbsp;Mario Gennaro ,&nbsp;Maccario Melania ,&nbsp;Pigoni Alessandro ,&nbsp;Maggioni Eleonora ,&nbsp;Brambilla Paolo ,&nbsp;Benedetti Francesco ,&nbsp;Vai Benedetta","doi":"10.1016/j.neubiorev.2025.106357","DOIUrl":"10.1016/j.neubiorev.2025.106357","url":null,"abstract":"<div><div>Machine learning (ML) could be useful in identifying reliable predictors of treatment response in affective and not affective psychoses, potentially helping to propose personalized interventions. In this systematic review and meta-analysis, we evaluated studies exploiting ML algorithms to predict the improvement of psychotic symptoms, cognition and quality of life in psychoses related to different treatments. We searched MEDLINE (PubMed), Web of Science, and PsycINFO databases updated until February 2024, identifying 64 articles published in English in peer-reviewed journals. We modelled a random-effects meta-analysis to estimate the overall accuracy reached in 51 studies. Subgroup analyses and meta regressions were performed to compare predictive accuracy across different predicted target class (i.e., improvers or responders <em>versus</em> not responders or treatment-resistant), diagnosis, input features, type and duration of treatments, ML algorithms, sample size, year of publication and quality assessment, evaluated with the PROBAST tool. ML models predicted a treatment response with a total accuracy of 80 % (95 %CI [0.76;0.83]), despite detecting a high heterogeneity (I²=0.89). Significant differences were observed between input features (<em>p</em> = .004) and treatments (<em>p</em> = .01). The best predictor was electroencephalography data (88 % of accuracy, 95 %CI [0.82;0.93], I²=0.50), followed by the combined treatments (85 % of accuracy, 95 %CI [0.82;0.87], I²=0.51). We identified a general low quality of studies, with 44 having a high risk of bias. Overall, ML seems a promising tool for predicting therapeutic outcomes in affective and not affective psychoses. However, specific attention should be paid to enhancing reproducibility and improving study methodology to better translate results into clinical practice.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106357"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does unfairness evoke anger or disgust? A quantitative neurofunctional dissection based on 25 years of neuroimaging","authors":"Xianyang Gan ,&nbsp;Ran Zhang ,&nbsp;Zihao Zheng ,&nbsp;Lan Wang ,&nbsp;Xi Yang ,&nbsp;Benjamin Klugah-Brown ,&nbsp;Ting Xu ,&nbsp;Nan Qiu ,&nbsp;Keith M. Kendrick ,&nbsp;Klaus Mathiak ,&nbsp;Justin Tiwald ,&nbsp;Dezhong Yao ,&nbsp;Benjamin Becker","doi":"10.1016/j.neubiorev.2025.106356","DOIUrl":"10.1016/j.neubiorev.2025.106356","url":null,"abstract":"<div><div>Over the last decades, the traditional ‘Homo economicus’ model has been increasingly challenged by converging evidence highlighting the critical impact of emotions on decision-making. A classic example is the perception of unfairness in the Ultimatum Game, where humans willingly sacrifice personal gains to punish fairness norm violators. While emotional mechanisms underlying such costly punishment are widely acknowledged, the distinct contributions of moral emotions, particularly anger and disgust, remain debated, partly due to methodological limitations in conventional experiments. Here, we leverage a quantitative neurofunctional dissection approach that integrates recent advances in neuroimaging meta-analyses, behavioral-level, network-level, and neurochemical-level decoding, drawing on data from 3266 participants from functional neuroimaging studies to determine the common and distinct neural representations between unfairness and the two moral emotions. Our results reveal that experiencing unfairness engages a widespread bilateral network encompassing insular, cingulate, and frontal regions, with dorsal striatal regions mediating the decision to reject unfair offers. Disgust engages a defensive-avoidance circuit encompassing amygdalar, occipital, and frontal regions, while anger engages non-overlapping systems including mid-cingulate, thalamic, and frontal regions. Unfairness shares common activation with both anger and disgust, respectively, in the anterior and mid-insula, while the latter additionally shows common recruitment of ventrolateral prefrontal and orbitofrontal cortices. Multimodal network, behavioral, and serotonergic decoding provide a more refined dissection of these results. Collectively, our results suggest a shared neuroaffective foundation through which emotions impact unfairness-induced punishment behavior, supporting the existence of a core brain circuit evolutionarily shaped to protect individuals from personal harm and enforce social norms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106356"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review: Biopsychosocial Factors Related to Attention-Deficit/Hyperactivity Disorder in Children/Adolescents with Neurofibromatosis Type 1.","authors":"Yang Hou, Liyan Yu, Matthew R Jamnik, Dan Liu, Emma Wilson-Lemoine, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, Luke Spoto, Michael Peper, Jonathan M Payne","doi":"10.1016/j.neubiorev.2025.106355","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106355","url":null,"abstract":"<p><p>This systematic review was conducted to provide a comprehensive summary of biopsychosocial factors associated with attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with Neurofibromatosis Type 1 (NF1), and identify key limitations and gaps in the current literature. Systematic literature searches were conducted in Scopus, PsycINFO, Web of Science, PubMed, and ProQuest Dissertations and Theses Global in March 2024. The searches identified 2,345 unique articles. Two researchers independently screened articles and extracted data. Inclusion criteria were met by 68 articles. We synthesized results across studies in a narrative format, following the Guidance on the Conduct of Narrative Synthesis in Systematic Reviews. Based on the biopsychosocial model of mental health, we grouped study findings on factors associated with ADHD into broad categories of biological (n = 33), psychological (n = 47), and social factors (n = 13), which were further divided into subcategories. Findings varied across biopsychosocial factors, ADHD-related variables (inattention, hyperactivity, impulsivity symptoms, or ADHD diagnosis), measurement methods, study designs, and statistical approaches. Psychological factors (e.g., executive functioning, IQ) were most commonly studied. Findings revealed consistent evidence for the link between informant-reported executive functioning problems and ADHD, whereas performance-based cognitive measures generally showed no significant associations. Most studies are cross-sectional and have small and nonrepresentative samples. Methodological limitations in previous studies hinder definitive conclusions on biopsychosocial factors associated with ADHD in NF1. Future research should use larger samples and longitudinal or experimental designs, explore understudied biological and social factors, and incorporate new technologies to improve understanding and interventions.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106355"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of motor dysfunction in functional neurological disorder: A narrative review","authors":"Alfred Pak-Kwan Lo ,&nbsp;Maryam Homayoun ,&nbsp;Alec J. Jamieson ,&nbsp;Ben J. Harrison ,&nbsp;Richard A. Kanaan","doi":"10.1016/j.neubiorev.2025.106358","DOIUrl":"10.1016/j.neubiorev.2025.106358","url":null,"abstract":"<div><div>One of the characteristic presentations of functional neurological disorder (FND) is with motor symptoms, such as weakness and tremor. While these symptoms are both common and disabling, how they arise at a mechanistic level remains unclear. This review provides an up-to-date account of the underpinnings of motor dysfunction in FND by integrating findings from neuroimaging, physiology, genetic, brain stimulation, and behavioral studies. A literature search was conducted systematically in MEDLINE and PsycINFO, resulting in 168 studies that met our inclusion criteria. Results generally suggest that patients, compared to healthy controls, have difficulties in predicting their own actions and detecting their bodily cues, limiting their capability for action inference. The literature also shows that patients tend to be hypersensitive to stress, accompanied by heightened linkage between their emotion and motor systems, when compared to healthy controls. It is also evident that, relative to controls, patients exhibit distorted action selection and excessive self-monitoring, implying abnormalities in top-down control. We discuss how these abnormal information processing patterns relate to specific motor symptoms experienced by patients with FND, thereby offering a framework that may facilitate the treatment of these symptoms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106358"},"PeriodicalIF":7.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Touch facilitates newborns’ self-regulation: Systematic review of multidimensional arousal outcomes","authors":"Irene Valori ,&nbsp;Jasmin L. Merkel ,&nbsp;Giovanna Furlan ,&nbsp;Tobias Grossmann ,&nbsp;Merle T. Fairhurst","doi":"10.1016/j.neubiorev.2025.106353","DOIUrl":"10.1016/j.neubiorev.2025.106353","url":null,"abstract":"<div><div>During the first month of life, exchanges between newborns and caregivers focus on helping babies regulate their physiological and behavioural states. Touch and bodily contact play a special role in facilitating arousal regulation and are often used to promote bonding, support at-risk babies, and manage pain. Here, we systematically review the extant evidence on the effects of touch interventions for newborns, specifically focusing on self-regulation and arousal as outcome measures. Seventy-two experimental studies met our inclusion criteria, comparing touch and control groups or within-subject conditions across a variety of physiological and behavioural outcomes. The types of touch interventions employed include skin-to-skin care, Kangaroo Care, massage therapy, Gentle Human Touch, and Yakson. Outcome measures include heart rate and heart rate variability, blood oxygenation and respiration rate, body temperature regulation, cortisol levels, and behavioural states (e.g., sleep and crying patterns). Most studies implemented touch interventions on premature babies and measured outcomes within the first month of life. Only a minority monitored the long-term effects of interventions or explored facilitating factors such as multisensory aspects, caregiver satisfaction, and sensitivity to the baby’s signals. Overall, the findings consistently show the benefits of touch in promoting the immediate self-regulation skills of newborns, particularly supporting the use of tactile interventions for premature babies and neonatal pain management in clinical contexts. Future research should further investigate the long-term, cascading effects of touch interventions on broader dimensions of child development and the child-caregiver dyad’s well-being as a whole.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106353"},"PeriodicalIF":7.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response effects of exogenous oxytocin on social cognition: A systematic review","authors":"Simon Barton ,&nbsp;Annika Pruin ,&nbsp;Janna Schulze ,&nbsp;Maximilian Kiebs ,&nbsp;Dirk Scheele ,&nbsp;René Hurlemann","doi":"10.1016/j.neubiorev.2025.106350","DOIUrl":"10.1016/j.neubiorev.2025.106350","url":null,"abstract":"<div><div>Oxytocin, a neuropeptide known for its role in social bonding, has garnered considerable attention for its potential to enhance social cognition in humans. Intranasal administration of oxytocin is the standard method in exogenous oxytocin research. This systematic review critically examines the effects of exogenously administered oxytocin on three core components of social cognition: emotion recognition, empathy, and interpersonal trust. By comparing findings across studies using intranasal oxytocin doses ranging from 1 IU to 48 IU in healthy adult humans, we evaluate evidence for a potential dose-response relationship. The majority of studies administered a standard dose of 24 IU and generally reported significant improvements in emotion recognition, empathy, and trust. However, divergent findings at this dose have also been observed. Evidence for both lower and higher doses remains mixed. Much of the support for the Inverted-U Curve hypothesis - suggesting that oxytocin’s effects follow a nonlinear trajectory with optimal outcomes at moderate doses - comes from studies lacking direct dose comparisons. Furthermore, the effects of oxytocin on social cognition appear to be strongly moderated by individual and contextual factors, raising questions about the generalizability of the Inverted-U model. Additional research is necessary to clarify the conditions under which dose-dependent effects occur.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"178 ","pages":"Article 106350"},"PeriodicalIF":7.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}