Neuroscience and Biobehavioral Reviews最新文献

{"title":"Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans","authors":"Lucie Berkovitch ,&nbsp;Baptiste Fauvel ,&nbsp;Katrin H. Preller ,&nbsp;Raphaël Gaillard","doi":"10.1016/j.neubiorev.2025.106239","DOIUrl":"10.1016/j.neubiorev.2025.106239","url":null,"abstract":"<div><div>Psilocybin is a psychedelic serotonergic compound that is renowned for its potent psychoactive effects. Over the past 15 years, an increasing number of controlled clinical trials showed that it has a fast-acting and sustainable efficacy in treating various psychiatric disorders. Neuroimaging studies have been conducted with the objective of elucidating the neurobiological mechanisms underlying the subjective and therapeutic effects of psilocybin. However, the diversity of neuroimaging techniques, tasks, and analytical approaches makes it difficult to gain a comprehensive overview of psilocybin's effects on the brain. To address this gap in the literature, we conducted a systematic review in the Medline, Psychinfo and Cochrane databases between January 1, 1990, and May 9, 2025, following PRISMA recommendations. A total of 81 articles met the inclusion criteria. A variety of neuroimaging techniques were employed in small samples of healthy volunteers and patients with medical conditions. The studies investigated the effects of psilocybin on brain activity and connectivity, both at rest and during cognitive tasks. They revealed that psilocybin reproducibly impacted neuronal networks such as the default mode network. However, other findings were more inconsistent. Psilocybin effects on the brain were associated with acute alterations in self-experience, sensory and emotional processing, and sustained effects on mood, personality, and social functioning. In patients with depression, clinical outcomes correlated with brain changes. This review indicates that psilocybin induces acute and long-lasting functional brain changes. While these neuroimaging data require confirmation and further expansion, they shed light on the mechanisms of psilocybin's acute subjective and therapeutic effects in humans.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106239"},"PeriodicalIF":7.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darwin in medicine and the neurosciences","authors":"Stefano Parmigiani,&nbsp;Paola Palanza,&nbsp;Martin Brüne","doi":"10.1016/j.neubiorev.2025.106238","DOIUrl":"10.1016/j.neubiorev.2025.106238","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106238"},"PeriodicalIF":7.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cognitive and neural bases of creative thought: A cross-domain systematic review and meta-analysis of transcranial direct current stimulation studies","authors":"Melody M.Y. Chan ,&nbsp;Eugene Cho ,&nbsp;Matthew A. Lambon Ralph ,&nbsp;Gail A. Robinson","doi":"10.1016/j.neubiorev.2025.106237","DOIUrl":"10.1016/j.neubiorev.2025.106237","url":null,"abstract":"<div><div>Creative thought enables humans to flexibly generate, evaluate and select novel and adaptive ideas across different contexts. Decades of research indicates that it involves two key aspects: retrieval of previously acquired knowledge and manipulation of that knowledge. However, the cognitive processes underpinning these aspects remain underspecified. The broader clinical-cognitive neuroscience literature suggests these functions rely on general-purpose cognitive mechanisms supporting semantic cognition, controlled episodic memory retrieval, and executive mechanisms. Transcranial direct current stimulation (tDCS) is a neuromodulation technique widely used in creativity and cognitive neuroscience research to examine causal brain-behaviour relationships. To identify converging evidence toward a unifying neurocognitive account of creative thought, we reviewed and meta-analysed 145 sham-controlled tDCS studies (involving 8399 healthy participants aged 18–40), drawn from electronic databases and previous reviews, across creativity and relevant cognitive neuroscience literatures. The results revealed that, only left lateral frontal anodal tDCS promotes creativity (p &lt; .01). In parallel, anodal tDCS over the same region also promotes improvement in many other cognitive processes, including more efficient processing of semantic knowledge (p &lt; .05), more accurate episodic memory retrieval (p &lt; .05), better and more efficient manipulation of buffered knowledge (all p &lt; .001), better self-initiated response generation (i.e., energization; p &lt; .05), and more efficient response selection amongst competing options (i.e., task-setting; p &lt; .01). By merging these previously separate literatures, tDCS studies – although heavily biased toward frontal montages – support the notion that creative thought arises from general-purpose cognitive mechanisms including controlled retrieval and temporary storage of semantic and episodic information, as well as executive mechanisms.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106237"},"PeriodicalIF":7.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic and phonological processes in Williams Syndrome: A systematic review and meta-analysis","authors":"A. Hippolyte ,&nbsp;S. Majerus ,&nbsp;M. Ponthot ,&nbsp;D.N. Fernandez ,&nbsp;L. Ibernon","doi":"10.1016/j.neubiorev.2025.106236","DOIUrl":"10.1016/j.neubiorev.2025.106236","url":null,"abstract":"<div><div>This meta-analysis focuses on acoustic, phonetic and phonological aspects of language processing in Williams syndrome (WS), a rare neurodevelopmental genetic disorder. Based on N = 51 papers, we aimed at identifying the status of these languages processes in WS relative to different types of control groups and we examined possible sources of variability of results through moderator analyses. At the acoustic level, evidence for hearing loss and impaired acoustic discrimination was observed. At the phonetic and sublexical phonological level, results were inconclusive due to limited literature. At the metaphonological level, WS individuals demonstrated better phonological awareness than nonverbal age-matched peers but performed below typically developing (TD) peers matched for verbal mental age. For phonological working memory WS performed worse than mental age matched TD peers but outperformed participants with other disabilities. At the lexical phonological level, WS demonstrated better phonological fluency skills than younger mental age matched peers. A wide range of heterogeneity was observed (I²=0–92.26 %). In some cases, the heterogeneity was partly explained by differences in control groups, but the largest part of heterogeneity could not be accounted for by the moderator variables included in the analysis. Future research needs to address sublexical phonological levels, to consider developmental trajectories and WS group variability, and to examine how impaired acoustic processes impact linguistic processes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106236"},"PeriodicalIF":7.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulating the rhythms of cognition","authors":"Jelena Trajkovic,&nbsp;Alexander T. Sack","doi":"10.1016/j.neubiorev.2025.106232","DOIUrl":"10.1016/j.neubiorev.2025.106232","url":null,"abstract":"<div><div>Rhythmic non-invasive brain stimulation (rh-NIBS) allows to modulate neural oscillations and study the functional role of these brain rhythms for cognition. We hope to draw attention to often neglected aspects of this field that limit the interpretations of the findings and their translational potential. We here review current rh-NIBS trends and propose to conceptually differentiate oscillatory synchronization, aimed at enhancing an intrinsic oscillatory amplitude, from frequency-shifting, designed to speed-up or slow-down a given oscillatory rhythm. At the same time, we offer a precise mechanistic account of these two rh-NIBS protocols that accounts for inter-individual differences in stimulation outcomes. Finally, we gap the bridge between entrainment, understood as an online manipulation of neural oscillations via rh-NIBS, versus plasticity, defined as the aftereffects of the TMS offline protocols. Specifically, we bring forward a promising possibility that the aftereffects of rh-NIBS protocols, preferably tuned to the dominant oscillatory frequency, might produce the desired outcome through a successful online oscillatory tuning, understood as a prerequisite for the generation of synaptic plasticity reflecting enduring aftereffects. This conceptual and mechanistic framework aims to provide a deeper theoretical understanding of recommended rh-NIBS best practices for noninvasively studying dynamic oscillation-cognition relationships in cognitive and clinical research.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106232"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls in people with Alzheimer’s disease: Exploring the role of inhibitory control","authors":"Marlee Wells ,&nbsp;Jane Alty ,&nbsp;Mark R. Hinder ,&nbsp;Rebecca J. St George","doi":"10.1016/j.neubiorev.2025.106228","DOIUrl":"10.1016/j.neubiorev.2025.106228","url":null,"abstract":"<div><div>On average, people with dementia fall more often than their age-matched peers, with serious consequences, yet the underlying reasons remain poorly understood. This narrative review explores relevant psychological, physiological and neuroimaging studies to discuss whether diminished inhibitory control contributes to poor balance and falls in people with Alzheimer’s Disease (AD), the most common form of dementia. <em>Inhibitory control</em>, a component of executive function, plays a vital role in suppressing dominant impulses or actions and regulating attention in favour of a desired outcome. Although objective tests of inhibitory control are not routinely used in clinical settings, research suggests inhibitory control declines early, and progressively, in AD. Postural tasks that require inhibitory control can improve the accuracy of distinguishing fallers from non-fallers beyond known factors. Neuroimaging studies link the prefrontal cortex to both inhibitory and postural control, and this region exhibits neuronal loss early in AD. Thus, emerging evidence suggests that accurately assessing inhibitory control could not only improve falls risk predictions but also aid AD detection.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106228"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the LC-NE system in attention: From cells, to systems, to sensory-motor control","authors":"Alexis S. Torres ,&nbsp;Matthew K. Robison ,&nbsp;Gene A. Brewer","doi":"10.1016/j.neubiorev.2025.106233","DOIUrl":"10.1016/j.neubiorev.2025.106233","url":null,"abstract":"<div><div>Attention control is a fundamental cognitive function that enables individuals to sustain focus, shift attention flexibly, and filter distractions in a goal-directed manner. The locus coeruleus-norepinephrine (LC-NE) system plays a pivotal role in this process by dynamically regulating arousal, prioritizing salient stimuli, and optimizing cognitive performance. This review synthesizes evidence from molecular, cellular, systems, cognitive neuroscience, and behavioral studies to elucidate the LC-NE system’s role in attention control. We first examine the neurophysiological mechanisms of the LC, highlighting its distinct firing patterns—tonic and phasic activity—and their impact on attention. Next, we integrate findings from animal models, human neuroimaging, electrophysiology, and computational modeling, demonstrating how LC-NE activity influences sensory processing, cognitive flexibility, and executive function. We interpret these findings through the lens of three major theoretical frameworks: Adaptive Gain Theory (AGT), which describes how LC activity optimizes task engagement, the Network Reset Hypothesis (NRH), which describes how optimizes network connectivity, and the Glutamate Amplifies NE Effects (GANE) model, which explains how NE enhances neural selectivity and suppresses irrelevant signals. Collectively, the evidence underscores the LC-NE system’s role in modulating the signal-to-noise ratio in cortical and subcortical circuits, thereby shaping attention and behavior. We conclude by discussing implications for individual differences, age-related cognitive decline, and emphasizing the need for interdisciplinary research that integrates emerging technologies to further unravel the complexities of LC function.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106233"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular basis of music-induced neuroplasticity in humans: A systematic review","authors":"Kirthana Kunikullaya U ,&nbsp;Marija Pranjić ,&nbsp;Alison Rigby ,&nbsp;Irene Pallás-Ferrer ,&nbsp;Harshini Anand ,&nbsp;Radhika Kunnavil ,&nbsp;Artur C. Jaschke","doi":"10.1016/j.neubiorev.2025.106219","DOIUrl":"10.1016/j.neubiorev.2025.106219","url":null,"abstract":"<div><div>Neuroscientific research on music-based activities has grown rapidly, shedding light on the health benefits of music across various domains. However, the molecular mechanisms by which music influences neuroplasticity in humans remain largely unexplored. This review aimed to synthesize and critically appraise existing research on molecular neuroplasticity in humans, with a specific focus on the effects of receptive and active music-based interventions (MBIs) and musical training. Following the PRISMA guidelines, a systematic search was conducted across four databases (MEDLINE, Embase, PsycINFO, and Scopus), for articles published between 2000 and December 2023. From an initial return of 3239 records, 15 studies met the inclusion criteria and were synthesized into three categories of music experiences: (1) receptive MBIs, (2) active MBIs, and (3) musical training. Both active and receptive MBIs were found to enhance neuroplasticity. Specifically, music listening was associated with relaxation and improved immune function, marked by the upregulation of genes related to neuroprotection and synaptic plasticity, while active MBIs consistently enhanced peripheral neurotrophic factors in both healthy and patient populations. Among musicians, neurogenetic alterations linked to music perception and production, neurogenesis, and neurotransmission were identified, with multiple studies highlighting the roles of Brain-Derived Neurotrophic Factor (BDNF), Alpha Synuclein (SNCA), and GATA2 (GATA Binding Protein 2) genes. Collectively, both MBIs and musical training induce neuroplastic changes by modulating neurogenetics, enhancing neurotrophins, altering hormonal levels, and reducing stress in humans. These findings highlight the need for further research to elucidate the molecular mechanisms underlying music's effects on the human brain, which could have implications for advancing therapeutic interventions for neuropsychological disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106219"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sleep paradox: The effect of weekend catch-up sleep on homeostasis and circadian misalignment","authors":"Fan-Chi Hsiao ,&nbsp;Yun-Hsin Huang ,&nbsp;Chien-Ming Yang","doi":"10.1016/j.neubiorev.2025.106231","DOIUrl":"10.1016/j.neubiorev.2025.106231","url":null,"abstract":"<div><div>Weekend catch-up sleep involves not only changes in sleep duration between weekdays and weekends but also changes in sleep timing. When people sleep less during the weekdays, they accumulate sleep debt and extend their sleep duration on weekends to compensate, which is related with the homeostatic process. Thus, extend their sleep duration on weekends seems to be a protectively strategy of daytime function, mental and physical health. However, not all studies support this protective effect. Sleep duration changes with sleep timing. The difference in sleep timing between weekdays and weekends might bring social jet lag (SJL). Sleep duration changes with sleep timing. The difference in sleep timing between weekdays and weekends can lead to SJL, representing the discrepancy between the biological clock and the social clock. This makes SJL an indicator of circadian misalignment, which is associated with poor daytime function, reduced nighttime sleep quality, and an increased risk of depression, metabolic disturbances, and other diseases. Paradoxically, the protective effect of weekend catch-up sleep duration on the homeostatic process (compensating for sleep debt) and the potential impact of weekend catch-up sleep timing on the circadian process (circadian misalignment) contradict each other. A more comprehensive understanding of weekend catch-up sleep is essential to investigate its mechanisms using the two-process model and other influencing factors.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106231"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The body intervenes: How active inference explains depression’s clinical presentation","authors":"Christopher G. Davey","doi":"10.1016/j.neubiorev.2025.106229","DOIUrl":"10.1016/j.neubiorev.2025.106229","url":null,"abstract":"<div><div>The low mood that characterises depression is accompanied by changes in bodily processes, manifested in symptoms such as insomnia, reduced appetite and fatigue. The active inference framework provides an explanation as to how mood-related symptoms are linked. It suggests that affective experiences arise from predictions about interoceptive states and their corresponding prediction errors, with the relative influence of each modified by precision weighting. Moods reflect long-term predictions about the state of the body, incorporating parameters related to sleep, appetite and energy levels. Depression emerges from the interplay between reduced confidence in long-term prospects and heightened expectation of shorter-term negative affect, which sees a re-weighting of the precision of interoceptive prediction errors. The ensuing bodily changes contribute to the emergence of depressed mood; and underpin disturbances in shorter-term interoceptive predictions and the experience of emotions such as anxiety and irritability. This framework details how interoceptive processes shape the phenomenological and symptomatic experience of depression, helping us to understand the disorder's multifaceted and often idiosyncratic clinical presentation, and with implications for the way we understand and treat depression and its co-morbidities.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"175 ","pages":"Article 106229"},"PeriodicalIF":7.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}