Neuroscience and Biobehavioral Reviews最新文献_第3页

Cognitive, psychological, and pharmacological correlates of susceptibility to (mis)information: Why we believe and how we resist 对（错误）信息的易感性的认知、心理和药理学相关：我们为什么相信以及我们如何抵制。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-14 DOI: 10.1016/j.neubiorev.2025.106339

Rafal Rygula, Michal Piksa, Agata Cieslik-Starkiewicz

{"title":"Cognitive, psychological, and pharmacological correlates of susceptibility to (mis)information: Why we believe and how we resist","authors":"Rafal Rygula, Michal Piksa, Agata Cieslik-Starkiewicz","doi":"10.1016/j.neubiorev.2025.106339","DOIUrl":"10.1016/j.neubiorev.2025.106339","url":null,"abstract":"<div><div>Misinformation is not a new challenge, but in the digital age, it spreads faster and reaches further than ever before, engaging a complex interplay of cognitive, psychological, and neurobiological mechanisms. This review explores how cognitive factors, personality traits, and environmental influences shape the way people engage with information. It is a narrative review that synthesizes the authors’ previously published empirical work, extended and contextualized in light of relevant findings from the broader literature. Consequently, we present an emerging four-phenotype model of misinformation susceptibility (Consumers, Doubters, Knowers, Duffers), highlighting distinct cognitive, psychological and behavioral profiles. Beyond cognition and psychology, we describe the neurobiological underpinnings of misinformation engagement, including recent findings that serotonergic modulation via selective serotonin reuptake inhibitors (SSRIs) can influence digital behavior without impairing truth discernment. We also evaluate strategies designed to counter misinformation, from cognitive debiasing techniques to interventions that reshape online environments. Finally, we propose future research directions, integrating psychiatry, neuroscience, and behavioral sciences to refine misinformation resistance strategies and explore its potential classification as a psychiatric phenomenon.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106339"},"PeriodicalIF":7.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of risk for adolescent self-harm and suicide: a systematic review and diagram of shared and unique factors in non-clinical samples 青少年自残和自杀风险的决定因素：非临床样本中共同和独特因素的系统回顾和图表。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-13 DOI: 10.1016/j.neubiorev.2025.106323

Bruno Santos , Bibiana Pedra Cruz Bettin , Rosa Maria Martins de Almeida

{"title":"Determinants of risk for adolescent self-harm and suicide: a systematic review and diagram of shared and unique factors in non-clinical samples","authors":"Bruno Santos , Bibiana Pedra Cruz Bettin , Rosa Maria Martins de Almeida","doi":"10.1016/j.neubiorev.2025.106323","DOIUrl":"10.1016/j.neubiorev.2025.106323","url":null,"abstract":"<div><div>Suicide ranks as the second leading cause of death among individuals aged 10–19. Estimates suggest that one-quarter of adolescents have self-harmed at least once, with 1 in 25 of them dying by suicide within 10 years of their initial self-harm presentation. Despite these alarming statistics, most risk assessment tools are designed for adults in clinical settings; a gap in the understanding of shared and unique risk factors for self-injurious behaviours (SIBs) in community adolescents. To address this, we systematically reviewed observational studies examining risk factors for self-harming and suicidal behaviours in non-clinical adolescents. Our protocol adhered to PRISMA guidelines and was registered in PROSPERO (CRD42023463134), with the research question structured using the PICOS framework. We systematically searched EMBASE, Scopus, PubMed, PsycINFO, and Web of Science, supplemented by snowball sampling, and evaluated quality with the Newcastle-Ottawa Scale. Two reviewers independently screened and extracted data, with a senior researcher resolving conflicts. Data were analysed through narrative synthesis. From 1651 articles identified, 8 were included, with sample sizes ranging from 70 to 73,648. Thirty-seven risk factors were identified and visually conveyed through a Sankey diagram. Key factors include female sex, history of SIBs, and vulnerabilities across psychological, neural, familial and social domains. Although many of the studies were cross-sectional and lacked robust ethnic representation, our findings reinforce previous literature linking adolescent SIB to specific individual and contextual factors, contributing a systematic overview that underscores non-clinical adolescent risk and the need for both early identification and tailored prevention and treatment strategies.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106323"},"PeriodicalIF":7.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of MDMA administration on oxytocin concentration levels: systematic review and a multilevel meta-analysis in humans MDMA给药对催产素浓度水平的影响：系统评价和人类多水平荟萃分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-12 DOI: 10.1016/j.neubiorev.2025.106324

Anna Vaslavski , Anna Harwood Gross , Salomon Israel , Leehe Peled-Avron

{"title":"The effect of MDMA administration on oxytocin concentration levels: systematic review and a multilevel meta-analysis in humans","authors":"Anna Vaslavski , Anna Harwood Gross , Salomon Israel , Leehe Peled-Avron","doi":"10.1016/j.neubiorev.2025.106324","DOIUrl":"10.1016/j.neubiorev.2025.106324","url":null,"abstract":"<div><div>3,4-Methylenedioxmethamphetamine (MDMA) has been shown to enhance social cognition, partly through its effects on oxytocin, a neuropeptide involved in social cognition. Despite growing evidence linking MDMA to increased oxytocin levels, no study has systematically examined this relationship across different doses, times, and participant characteristics. This systematic review and meta-analysis evaluates the effects of MDMA administration on peripheral oxytocin levels in humans. A systematic search identified ten studies, comprising 39 effect size estimates. Multilevel meta-analyses were conducted using Hedge’s g as the primary outcome, with dose, time of measurement, and sex as moderators. Results revealed that oxytocin levels increased over time, peaking between 150 and 200 min, before declining. The dose did not significantly predict oxytocin changes, and a trend suggested that samples with a higher proportion of female participants exhibited smaller increases in oxytocin levels. These findings suggest that MDMA transiently elevates oxytocin levels in a time-dependent manner, potentially contributing to its prosocial effects. Importantly, these findings may guide oxytocin-informed timing of MDMA-assisted psychotherapy sessions. Standardization of methods and larger sample sizes are needed to clarify these effects and optimize the therapeutic benefits of MDMA.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106324"},"PeriodicalIF":7.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches to map cortical excitability beyond the primary motor cortex – Perspectives from cognitive neuroscience, multimodal imaging and clinical applications 从认知神经科学、多模态成像和临床应用的角度研究初级运动皮层以外的皮层兴奋性。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-12 DOI: 10.1016/j.neubiorev.2025.106338

Anna-Lisa Schuler , Martin Tik , Elisa Kallioniemi , Ana Suller Marti , Zhengchen Cai , Giovanni Pellegrino

{"title":"Approaches to map cortical excitability beyond the primary motor cortex – Perspectives from cognitive neuroscience, multimodal imaging and clinical applications","authors":"Anna-Lisa Schuler , Martin Tik , Elisa Kallioniemi , Ana Suller Marti , Zhengchen Cai , Giovanni Pellegrino","doi":"10.1016/j.neubiorev.2025.106338","DOIUrl":"10.1016/j.neubiorev.2025.106338","url":null,"abstract":"<div><div>Excitability is a neuronal property quantified as the magnitude of neural response to stimuli. It plays a crucial role in information processing and is disrupted in various neuropsychiatric conditions. In humans, non-invasive measurements of brain excitability have been mostly limited to the primary motor cortex. Here, the response to Transcranial Magnetic Stimulation (TMS) is quantified as the magnitude of the muscular contraction. TMS mapping of brain excitability outside the motor cortex, simultaneously across brain areas, and in deep regions is challenging. Indeed, TMS has little depth penetration, and can only probe one cortical point at a time. Furthermore, the measurement of the responses to stimuli outside the motor cortex requires simultaneous neuroimaging, such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Possible solutions include the application of stimulation approaches alternative to TMS, and the investigation of resting state properties of electromagnetic and hemodynamic brain activity. We show that, in combination with TMS or alone, neuroimaging will progressively allow non-invasive and accurate mapping of excitability with high spatio-temporal resolution, across the entire brain, and non-invasively. This will mark a critical advancement for stimulation thresholding in basic neuroscience and clinical medicine, as well as diagnostics of deviant excitability patterns in neuropsychiatric conditions. It is the aim of this review to critically discuss the state-of-the-art of whole brain excitability mapping and provide an outlook on neuroscience and clinical implications.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106338"},"PeriodicalIF":7.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “An ALE meta-analysis of pain processing alterations in fibromyalgia: Toward an evidence-based process model” [Neurosci. Biobehav. Rev. 176 (2025) 106303] “纤维肌痛症疼痛处理改变的ALE荟萃分析：循证过程模型”的更正[神经科学]。Biobehav。Rev. 176(2025) 106303]。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-09 DOI: 10.1016/j.neubiorev.2025.106321

Marco Cavicchioli , Alberto Caruso , Andrea Scalabrini , Alessandro Torelli , Sara Bottiroli , Anna Pichiecchio , Elena Prodi , Martina Cangelosi , Carlo Lai , Paolo Vitali , Luca Maria Sconfienza , Piercarlo Sarzi-Puttini , Federica Galli

引用次数: 0

Linguistic structure as a guiding principle for human neuroscience 语言结构作为人类神经科学的指导原则。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-06 DOI: 10.1016/j.neubiorev.2025.106322

Anna Mai , Andrea E. Martin

引用次数: 0

A systematic review and meta-analysis of sex differences in the relationship between cardiac interoceptive accuracy and emotion 心脏内感受准确度与情绪关系性别差异的系统回顾与meta分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106318

Sarina Afzali Shamsabad , Alexandra Edwards , Rebecca Brewer , Jennifer Murphy

{"title":"A systematic review and meta-analysis of sex differences in the relationship between cardiac interoceptive accuracy and emotion","authors":"Sarina Afzali Shamsabad , Alexandra Edwards , Rebecca Brewer , Jennifer Murphy","doi":"10.1016/j.neubiorev.2025.106318","DOIUrl":"10.1016/j.neubiorev.2025.106318","url":null,"abstract":"<div><div>Interoceptive accuracy, the ability to correctly perceive internal bodily signals, is considered integral to emotional experience. However, surprising evidence suggests that whilst females tend to have poorer interoceptive accuracy than males, they tend to have better emotion processing ability and rate their emotional competence higher. The current systematic review and meta-analysis aimed to investigate sex differences in the relationship between cardiac interoceptive accuracy and emotion. A review of three databases (PsychInfo, Web of Science, PubMed) yielded 2707 abstracts, resulting in 94 eligible studies. Authors of eligible studies were contacted for sex disaggregated summary statistics. 33 and 30 studies were included in the qualitative and quantitative synthesis, respectively. Overall, we found little evidence of a relationship between cardiac interoceptive accuracy and measures of emotion when examining pooled groups and after sex disaggregation. These results question the proposal that cardiac interoceptive accuracy, as routinely measured, relates to emotion. The implications of these results are discussed considering limitations of our current measures of cardiac interoceptive accuracy and emotion.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106318"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights 物质使用障碍的精准医学：整合行为、环境和生物学见解。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106311

Cyprien G.J. Guerrin , Debbie R.M. Tesselaar , Jan Booij , Arnt F.A. Schellekens , Judith R. Homberg

{"title":"Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights","authors":"Cyprien G.J. Guerrin , Debbie R.M. Tesselaar , Jan Booij , Arnt F.A. Schellekens , Judith R. Homberg","doi":"10.1016/j.neubiorev.2025.106311","DOIUrl":"10.1016/j.neubiorev.2025.106311","url":null,"abstract":"<div><div>Substance use disorders (SUD) are chronic, relapsing conditions marked by high variability in treatment response and frequent relapse. This variability arises from complex interactions among behavioral, environmental, and biological factors unique to each individual. Precision medicine, which tailors treatment to patient-specific characteristics, offers a promising avenue to address these challenges. This review explores key factors influencing SUD, including severity, comorbidities, drug use motives, polysubstance use, cognitive impairments, and biological and environmental influences. Advanced neuroimaging, such as MRI and PET, enables patient subtyping by identifying altered brain mechanisms, including reward, relief, and cognitive pathways, and striatal dopamine D<sub>2/3</sub> receptor binding. Pharmacogenetic and epigenetic studies uncover how variations in dopaminergic, serotoninergic, and opioidergic systems shape treatment outcomes. Emerging biomarkers, such as neurofilament light chain, offer non-invasive relapse monitoring. Multifactorial models integrating behavioral and neural markers outperform single-factor approaches in predicting treatment success. Machine learning refines these models, while longitudinal and preclinical studies support individualized care. Despite translational hurdles, precision medicine offers transformative potential for improving SUD treatment outcomes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106311"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural bases of meaningful intransitive gestures: A meta-analysis of lesion and fMRI studies 有意义不及物手势的神经基础：损伤和功能磁共振研究的荟萃分析。

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-08-05 DOI: 10.1016/j.neubiorev.2025.106316

Josselin Baumard , Alice Laniepce , Léna Guezouli , François Osiurak , Mathieu Lesourd , Angela Bartolo

{"title":"The neural bases of meaningful intransitive gestures: A meta-analysis of lesion and fMRI studies","authors":"Josselin Baumard , Alice Laniepce , Léna Guezouli , François Osiurak , Mathieu Lesourd , Angela Bartolo","doi":"10.1016/j.neubiorev.2025.106316","DOIUrl":"10.1016/j.neubiorev.2025.106316","url":null,"abstract":"<div><div>Meaningful intransitive (MFI) gestures have long been used by clinicians and researchers to assess gesture production and recognition, especially in the context of neuropsychological disorders like apraxia. Their neural bases, however, remain unclear. The goal of this systematic, theory-driven meta-analysis of 6 lesion studies and 21 fMRI studies was to investigate the cerebral networks of MFI gestures. The results suggested that MFI gesture processing depends on a large, left-lateralized, cortico-subcortical, fronto-temporo-insular and cerebellar neural network also involved in social cognition and skills. A bilateral cluster was also found in medial and cingulate brain regions. The left inferior parietal lobe, typically involved in tool use and imitation skills, was part of this network for gesture production – although it did not survive statistical control. These results challenge traditional neurocognitive models and suggest that MFI gestures, although represented widely in the brain, call for specific socio-cognitive processes. The discussion offers a comprehensive framework of the neural bases of MFI gestures, along with methodological considerations and future directions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"177 ","pages":"Article 106316"},"PeriodicalIF":7.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing neural variability: Implications for brain research and non-invasive brain stimulation 利用神经变异性：对大脑研究和非侵入性脑刺激的影响

IF 7.9 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-07-31 DOI: 10.1016/j.neubiorev.2025.106312

Carlo Miniussi , Marta Bortoletto

{"title":"Harnessing neural variability: Implications for brain research and non-invasive brain stimulation","authors":"Carlo Miniussi , Marta Bortoletto","doi":"10.1016/j.neubiorev.2025.106312","DOIUrl":"10.1016/j.neubiorev.2025.106312","url":null,"abstract":"<div><div>Neural variability, traditionally viewed as a barrier to consistent outcomes across all areas of neuroscience, is increasingly recognized as a critical element of brain function. This manuscript explores the idea that neural variability and neural noise, rather than being detrimental, is essential for enhancing adaptability and robustness in neural systems. By capturing this variability through indices that accurately represent an individual neural state through detailed brain activity recordings and advanced analytical techniques, brain research and more specifically non-invasive brain stimulation protocols can be optimized for individual brain states, thereby improving outcomes. The manuscript emphasizes the importance of capturing individual neural variability for developing more precise and effective neurostimulation/neuromodulation protocols. It also explores the roles of neural variability and noise in relation to excitability, plasticity, and homeostatic regulation, proposing a framework change for understanding NIBS effects on brain function and behaviour. This approach signifies a shift from minimizing neural variability to leveraging it strategically, offering new insights for research and clinical applications.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"176 ","pages":"Article 106312"},"PeriodicalIF":7.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0