Neuroscience and Biobehavioral Reviews最新文献

{"title":"The double-edged sword of stress: A systematic meta-analysis on how stress impacts creativity","authors":"Yi Huang ,&nbsp;Rongjun Yu","doi":"10.1016/j.neubiorev.2025.106113","DOIUrl":"10.1016/j.neubiorev.2025.106113","url":null,"abstract":"<div><div>The present study provides up-to-date meta-analytical estimates of the impact of experimentally induced stress on individuals’ creative performance. Using a three-level meta-analytic model, we observed an overall negative effect of stress on creativity (d = −0.20). Our analysis reveals that this relationship is nuanced, and influenced by a variety of factors. Social-evaluative threats (SETs) did not significantly affect creativity overall (d = −0.08). Specifically, tests significantly reduced creativity, while competition showed a non-significant positive trend and (expected) performance evaluation showed a non-significant negative trend. Furthermore, results showed that mild SETs (one element) slightly but not significantly increased creativity, whereas severe SETs (three elements) significantly decreased it, indicating a curvilinear relationship. Non-social stressors, including time pressure and physical stress, significantly hindered creative performance (d = −0.45), with challenging tasks also showing a negative but non-significant effect. Additionally, the impact of stress on creativity varied by age group. Children’s creativity was notably reduced by competition, physical stress, and challenging tasks, whereas adults and adolescents’ creativity appeared to benefit from competition. Adults’ creative performance was most negatively impacted by time pressure and remained relatively stable across other stressors. These findings underscore the complex and multifaceted nature of the effects of stress on creativity. The theoretical and practical implications are discussed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106113"},"PeriodicalIF":7.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humanized rodent models of neurodegenerative diseases and other brain disorders","authors":"Xinru Zhang ,&nbsp;Jianxiang Wang ,&nbsp;Jiewen Zhang ,&nbsp;Chao Jiang ,&nbsp;Xuezhong Liu ,&nbsp;Shuaijiang Wang ,&nbsp;Zhenhua Zhang ,&nbsp;Yousef Rastegar-Kashkooli ,&nbsp;Fatemeh Dialameh ,&nbsp;Qinfeng Peng ,&nbsp;Jin Tao ,&nbsp;Ruoqi Ding ,&nbsp;Junyang Wang ,&nbsp;Nannan Cheng ,&nbsp;Menglu Wang ,&nbsp;Fushun Wang ,&nbsp;Nan Li ,&nbsp;Na Xing ,&nbsp;Xuemei Chen ,&nbsp;Xiaochong Fan ,&nbsp;Jian Wang","doi":"10.1016/j.neubiorev.2025.106112","DOIUrl":"10.1016/j.neubiorev.2025.106112","url":null,"abstract":"<div><div>Central Nervous System (CNS) diseases significantly affect human health. However, replicating the onset, progression, and pathology of these diseases in rodents is challenging. To address this issue, researchers have developed humanized animal models. These models introduce human genes or cells into rodents. As a result, rodents become more suitable for studying human CNS diseases and their therapies <em>in vivo</em>. This review explores the preparation protocols, pathological and behavioral characteristics, benefits, significance, and limitations of humanized rodent models in researching various CNS diseases, particularly Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, glial cells-related CNS diseases, N-methyl-D-aspartic acid receptor encephalitis, and others. Humanized rodent models have expanded the opportunities for <em>in vivo</em> exploration of human neurodegenerative diseases, other brain disorders, and their treatments. We can enhance translational research on CNS disorders by developing, investigating, and utilizing these models.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106112"},"PeriodicalIF":7.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive coding and dimension-selective attention enhance the lateralization of spoken language processing","authors":"Basil C. Preisig ,&nbsp;Martin Meyer","doi":"10.1016/j.neubiorev.2025.106111","DOIUrl":"10.1016/j.neubiorev.2025.106111","url":null,"abstract":"<div><div>Hemispheric lateralization in speech and language processing exemplifies functional brain specialization. Seminal work in patients with left hemisphere damage highlighted the left-hemispheric dominance in language functions. However, speech processing is not confined to the left hemisphere. Hence, some researchers associate lateralization with auditory processing asymmetries: slow temporal and fine spectral acoustic information is preferentially processed in right auditory regions, while faster temporal information is primarily handled by left auditory regions. Other scholars posit that lateralization relates more to linguistic processing, particularly for speech and speech-like stimuli. We argue that these seemingly distinct accounts are interdependent. Linguistic analysis of speech relies on top-down processes, such as predictive coding and dimension-selective auditory attention, which enhance lateralized processing by engaging left-lateralized sensorimotor networks. Our review highlights that lateralization is weaker for simple sounds, stronger for speech-like sounds, and strongest for meaningful speech. Evidence shows that predictive speech processing and selective attention enhance lateralization. We illustrate that these top-down processes rely on left-lateralized sensorimotor networks and provide insights into the role of these networks in speech processing.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106111"},"PeriodicalIF":7.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis\" Neurosci. Biobehav. Rev. 161 (2024) 105690.","authors":"Jessica Ahrens, Farida Zaher, Rachel A Rabin, Clifford M Cassidy, Lena Palaniyappan","doi":"10.1016/j.neubiorev.2025.106102","DOIUrl":"https://doi.org/10.1016/j.neubiorev.2025.106102","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":" ","pages":"106102"},"PeriodicalIF":7.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of opioid antagonist in patients with binge eating behavior: A systemic review and meta-analysis","authors":"Yi-Ya Fang ,&nbsp;Yi-Chun Yeh ,&nbsp;Tai-Ling Liu ,&nbsp;Hsu Tien-Wei ,&nbsp;Chih-Hung Ko","doi":"10.1016/j.neubiorev.2025.106108","DOIUrl":"10.1016/j.neubiorev.2025.106108","url":null,"abstract":"<div><h3>Background</h3><div>Binge eating (BE) involves consuming unusually large amounts of food within a short period and feeling a loss of control. Neurobiological mechanisms underlying BE involve dysregulation of reward and inhibitory control systems, with the endogenous opioid system playing a key role. Opioid antagonists and the combination therapies with bupropion may have potential to reduce BE by affecting the reward system, but evidence regarding their effectiveness remains inconclusive. This meta-analysis reviewed randomized controlled trials (RCTs) exploring the effects of opioid antagonists on BE frequency, BE severity, body weight, and mood.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, Cochrane CENTRAL, Web of Science, and ClinicalTrials.gov to identify RCTs published before May 14, 2023,. The primary outcomes were BE severity and frequency. The secondary outcomes were percentage change in body weight and depressive symptoms.</div></div><div><h3>Results</h3><div>Eight RCTs were included in our analysis. Opioid antagonists significantly reduced BE frequency (standard difference in means [SMD] = −0.624, 95 % confidence interval [CI] = −1.181 to −0.067, p = 0.028) and changes in body weight percentage (SMD = −0.981, 95 % CI = −1.657 to −0.305, p = 0.004), with a moderate-to-large effect size. Conversely, opioid antagonists didn’t significantly improve BE severity (Hedges’ g = −0.210, 95 % CI = −0.431 to 0.011, p = 0.063) or depressive symptoms (Hedges’ g = −0.190, 95 % CI = −0.434 to 0.053, p = 0.125). Meta-regression analysis revealed that the dosage of naltrexone served as a moderator in reducing BE frequency and body weight percentage.</div></div><div><h3>Conclusion</h3><div>The present meta-analysis indicated that opioid antagonists effectively alleviate BE frequency and reduce percentage loss in body weight.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106108"},"PeriodicalIF":7.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastability in the wild: A scoping review of empirical neuroimaging studies in humans","authors":"Maria Teresa Wijaya ,&nbsp;Sammi T.S.T. Mabel-Kenzie ,&nbsp;Guang Ouyang ,&nbsp;Tatia M.C. Lee","doi":"10.1016/j.neubiorev.2025.106106","DOIUrl":"10.1016/j.neubiorev.2025.106106","url":null,"abstract":"<div><div>Metastability is proposed as the mechanism supporting our adaptive responses to the environment. While extensive research has characterized brain metastability during rest and task performance, prior studies have mainly focused on understanding underlying mechanisms, with limited exploration of its application in mental processes and behaviors. This scoping review offers an overview of the existing empirical literature in this area. Through a systematic search that included 36 articles, our results reveal a predominance of resting-state fMRI studies, variability in how metastability is defined, and a lack of consideration for common confounds in neuroimaging data. The review concludes with suggestions for future research directions to address crucial unresolved issues in the field.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106106"},"PeriodicalIF":7.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value-based decision-making deficits in non-suicidal self-injury: A systematic review and meta-analysis","authors":"Yuhan Jiang ,&nbsp;Ying Zeng ,&nbsp;Mengli Zhang ,&nbsp;Hongshuo Wang ,&nbsp;Wei He ,&nbsp;Pengfei Xu ,&nbsp;Hui Ai","doi":"10.1016/j.neubiorev.2025.106107","DOIUrl":"10.1016/j.neubiorev.2025.106107","url":null,"abstract":"<div><div>Non-suicidal self-injury (NSSI) is a significant global mental health issue. However, whether the deficit in value-based decision-making processing is the consistently key mechanisms of NSSI across studies with heterogeneous decision-making tasks remains uncertain. Hence, we reviewed literature on value-based decision-making and its moderating factors in NSSI, and then conducted a meta-analysis on studies in NSSI, specifically with Iowa Gambling Task. In total, 31 studies with 8417 participants aged from 8 to 50 were included in the systematic review of and 8 studies with 657 participants aged from 10 to 37 included in the meta-analysis. We found consistent impairments in value-based decision-making processing among individuals who engage in NSSI. Importantly, age is a significant moderator, with adolescents with NSSI performance worse, exhibiting increased reward sensitivity and preference for immediate rewards compared to other age groups. These results suggest the important role of value-based decision making in NSSI behaviors, especially during the development of adolescents. Our work provides new insights and integrative evidence for decision-making based prevention and intervention of NSSI.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106107"},"PeriodicalIF":7.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception and mental health in middle-aged and elderly adults: A systematic review and meta-analysis","authors":"Meiling Qi,&nbsp;Xiaona Shen,&nbsp;Yue Zeng,&nbsp;Xiaohe Lin,&nbsp;Muhammad Suliman,&nbsp;Ping Li","doi":"10.1016/j.neubiorev.2025.106104","DOIUrl":"10.1016/j.neubiorev.2025.106104","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies have identified interoceptive dysfunction as a critical biomarker for emotional disorders. It is well-established that aging correlates with a deterioration in interoceptive capabilities, which consequently affects emotional processing dynamics.</div></div><div><h3>Methods</h3><div>This study performed a systematic review and meta-analysis to evaluate the associations between interoceptive variants and mental health in middle-aged and elderly adults. Three English databases, including PubMed, Web of Science, and Medline (via EBSCO), were electronically searched from inception through December 2023. The study quality and meta-analysis were performed using the MMAT and RevMan 5.4 software.</div></div><div><h3>Results</h3><div>A total of 21 studies were included in this systematic review, and data from 14 studies were used in the meta-analysis. Favorable associations were seen between interoception and depression (pooled <em>r</em> = -0.11 (95CI%: −0.19 to −0.03), <em>z</em> = 2.72, <em>p</em> = 0.006, <em>I</em>^<em>2</em>= 0 %), alexithymia (pooled <em>r</em> = -0.25 (95CI%: −0.35 to −0.16), <em>z</em> = 4.84, <em>p</em> &lt; 0.001, <em>I</em>^<em>2</em>= 31 %), and emotion regulation (pooled <em>r</em> = 0.30 (95CI%: 0.18–0.41), <em>z</em> = 4.63, <em>p</em> &lt; 0.001, <em>I</em>^<em>2</em>= 33 %). Interoception showed no significant correlation with other mental health outcomes.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis underscore the importance of interoception in understanding the underlying neural mechanisms of depression, alexithymia, and emotion regulation in middle-aged and older adults. Interoceptive training could also potentially serve as an effective strategy for promoting mental health within this demographic.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106104"},"PeriodicalIF":7.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating neural substrates, diabetes self-management, and behavior change for tailored lifestyle interventions in type-2 diabetes: A neurobehavioral perspective","authors":"Danylo F. Cabral ,&nbsp;Marcelo Bigliassi ,&nbsp;Timothy P. Morris ,&nbsp;Joyce R. Gomes-Osman ,&nbsp;Peter J. Fried","doi":"10.1016/j.neubiorev.2025.106103","DOIUrl":"10.1016/j.neubiorev.2025.106103","url":null,"abstract":"<div><div>Understanding the neural mechanisms that underlie behavior change is critical for improving lifestyle management in type 2 diabetes. Individuals with type 2 diabetes face unique challenges in adopting and maintaining healthy behaviors, which can be influenced by alterations in brain function and plasticity, potentially leading to cognitive impairment. Diabetes self-management education and support (DSMES) programs aim to enhance lifestyle changes and promote better health outcomes while reducing cognitive decline. However, complex neural disruptions in critical regions for cognitive processes like the prefrontal cortex and parietal lobe present significant challenges. Given the likely role of neural mechanisms in behavioral choices, understanding how type 2 diabetes affects these neural substrates is crucial for developing effective interventions. Despite considerable research efforts aimed at testing lifestyle interventions, a critical gap remains in understanding the cognitive and behavioral components of successful diabetes self-management, the neural substrates of those components, and the impact of diabetes on those neural substrates. Bridging this gap necessitates a comprehensive examination integrating neural processes, DSMES strategies, and behavior change models. Thus, this perspective review highlights the urgent need to address the knowledge gaps surrounding the neural correlates of diabetes self-management and the integration of behavioral models into intervention frameworks. We propose a hypothesis-generating question and present preliminary findings comparing neural plasticity, executive functions, and lifestyle behavior among individuals with type 2 diabetes, pre-diabetes, and healthy controls. By elucidating the neural substrates underpinning diabetes and exploring their implications for DSMES and readiness to change, we can pave the way for more effective, personalized approaches to diabetes care.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106103"},"PeriodicalIF":7.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social and affective neuroscience and the emergence of the study of empathy related behaviors in rodents","authors":"M.L. Smith","doi":"10.1016/j.neubiorev.2025.106105","DOIUrl":"10.1016/j.neubiorev.2025.106105","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106105"},"PeriodicalIF":7.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}