Neuroscience and Biobehavioral Reviews最新文献_第3页

Utilizing blood inflammatory markers in alcohol studies: Considerations and recommendations for study design, sample collection, and data analysis 在酒精研究中利用血液炎症标志物：对研究设计、样本收集和数据分析的考虑和建议

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-09 DOI: 10.1016/j.neubiorev.2025.106142

Erica N. Grodin , Hollis Karoly , Brittney D. Browning , Leon Coleman , Mehdi Farokhnia , Lindsay A. Kryszak , Lindsay R. Meredith , Lindsay M. Squeglia

{"title":"Utilizing blood inflammatory markers in alcohol studies: Considerations and recommendations for study design, sample collection, and data analysis","authors":"Erica N. Grodin , Hollis Karoly , Brittney D. Browning , Leon Coleman , Mehdi Farokhnia , Lindsay A. Kryszak , Lindsay R. Meredith , Lindsay M. Squeglia","doi":"10.1016/j.neubiorev.2025.106142","DOIUrl":"10.1016/j.neubiorev.2025.106142","url":null,"abstract":"<div><div>A large body of evidence suggests that heavy alcohol use is associated with dysregulated immune function, and that immune dysfunction in turn contributes to the pathophysiology of alcohol use disorder (AUD). As such, alcohol researchers have increasingly begun to include measurements of immune function—primarily peripheral circulating cytokines—in human studies, with the goal of testing associations with clinically-relevant behavioral measures. To date, findings and implications from these studies have been inconsistent and difficult to interpret, likely due to methodological challenges related to study design and implementation. In particular, the existing literature has demonstrated sample processing concerns, differences in assay methods, limited selection of analytes, and sample selection biases, all of which may contribute to inconsistent results. We briefly review the field, discuss these and other challenges, and propose guidance for designing studies on inflammation among heavy-drinking human participants. We note that conducting such studies requires appreciable consideration and planning, and ideally should involve an interdisciplinary team of experts, including immunologists, physiologists, and technical experts in bioassays, alongside experts in the field of interest (e.g., AUD). We highlight the importance of considering participant selection, analyte selection, sample collection, sample handling and storage, and assay methods, and suggest that the field move towards standardization of procedures and reporting. We propose that undertaking these changes in study design and implementation should produce consilience in findings and aid in our overall understanding of the complex relationship between alcohol exposure and immune function.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106142"},"PeriodicalIF":7.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced and long-term meditation and the autonomic nervous system: A review and synthesis 高级和长期冥想与自主神经系统：综述和综合

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-09 DOI: 10.1016/j.neubiorev.2025.106141

Idil Sezer , Matthew D. Sacchet

{"title":"Advanced and long-term meditation and the autonomic nervous system: A review and synthesis","authors":"Idil Sezer , Matthew D. Sacchet","doi":"10.1016/j.neubiorev.2025.106141","DOIUrl":"10.1016/j.neubiorev.2025.106141","url":null,"abstract":"<div><div>Meditation has become prominent in both clinical and non-clinical applications for its effects on psychological and physical well-being. Long-term meditators, who have dedicated extensive time to their practice, present a unique opportunity to explore the effects of prolonged meditation training on the autonomic nervous system. Research has reported concomitant activation of both sympathetic (aroused) and parasympathetic (relaxed) branches of the autonomic nervous system during some forms of meditation, leading to the term ‘relaxed alertness.’ However, findings are not consistent, with reports of both sympathetic and parasympathetic activation, sympathetic-only, parasympathetic-only, or temporally variable activations, depending on several factors. This review synthesizes these heterogeneous and seemingly inconsistent results in relation to three explanatory factors: (1) specific classification of style or type of meditation; (2) specific definition of the level of expertise of the meditators; and (3) intra-individual variations within a given meditation practice. When these factors are considered, convergent and meaningful patterns emerge, allowing for a shift from the broad notion of 'long-term' meditation to a more precise characterization of 'advanced' meditation, highlighting skills, states, and stages of mastery developed over time. Our synthesis is particularly useful for understanding both long-term and advanced meditation, as it reveals specific heart rate variability patterns, including very low and low-frequency spectral power peaks, along with cardiac and respiratory coupling. Better characterization of the role of the autonomic nervous system in the context of advanced meditation promises to inform improved meditation training, including training assisted by technology, toward more impactful outcomes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106141"},"PeriodicalIF":7.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological mechanisms underpinning change in intolerance of uncertainty across anxiety-related disorders: New insights for translational research 焦虑相关障碍中不确定性耐受变化的心理机制：转化研究的新见解

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-09 DOI: 10.1016/j.neubiorev.2025.106138

Jayne Morriss

{"title":"Psychological mechanisms underpinning change in intolerance of uncertainty across anxiety-related disorders: New insights for translational research","authors":"Jayne Morriss","doi":"10.1016/j.neubiorev.2025.106138","DOIUrl":"10.1016/j.neubiorev.2025.106138","url":null,"abstract":"<div><div>Intolerance of uncertainty (IU), the tendency to find uncertainty negative, is a fundamental transdiagnostic dimension across anxiety-related disorders. Over the past two decades, there has been an increase in both clinical and experimental research on the role of IU in the maintenance and treatment of anxiety-related disorders. However, there has been a lack of integration of research findings from a mechanistic perspective, which has slowed progress in translational research. This review seeks to fill this gap by synthesising the clinical (e.g. randomised controlled trials) and experimental (e.g. lab-based) literature on the psychological mechanisms that drive change in IU across anxiety-related disorders. The review highlighted that: (1) cognitive restructuring, supported by mechanisms such as cognitive appraisal, modify IU-related cognitions, (2) behavioural exposures, supported by mechanisms such as inhibitory learning, alter IU-related cognitions and physiological arousal, and (3) mindfulness techniques underpinned by mechanisms such as attentional monitoring, decentering, and acceptance, change IU-related cognitions. Across the different therapeutic techniques reviewed, there was a lack of evidence for how different mechanisms change IU-related emotions and behaviours. Directions for further research include directly comparing the effectiveness of different mechanisms that produce change in IU across anxiety disorders and other mental health disorders, and examining the specificity of change in IU over other anxious traits. Overall, the findings provide a foundation for future translational research efforts to build upon maximising existing treatment interventions and/or to develop novel treatment interventions to target dispositional IU and situational uncertainty-related distress in anxiety-related disorders and beyond.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106138"},"PeriodicalIF":7.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gap of brain and experience – Converging Neurophenomenology with Spatiotemporal Neuroscience 弥合脑与经验的鸿沟——神经现象学与时空神经科学的融合

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-07 DOI: 10.1016/j.neubiorev.2025.106139

Georg Northoff , Bianca Ventura

{"title":"Bridging the gap of brain and experience – Converging Neurophenomenology with Spatiotemporal Neuroscience","authors":"Georg Northoff , Bianca Ventura","doi":"10.1016/j.neubiorev.2025.106139","DOIUrl":"10.1016/j.neubiorev.2025.106139","url":null,"abstract":"<div><div>Neuroscience faces the challenge of connecting brain and mind, with the mind manifesting in first-person experience while the brain’s neural activity can only be investigated in third-person perspective. To connect neural and mental states, Neurophenomenology provides a methodological toolkit for systematically linking first-person subjective experience with third-person objective observations of the brain’s neural activity. However, beyond providing a systematic methodological strategy (‘disciplined circularity’), it leaves open how neural activity and subjective experience are related among themselves, independent of our methodological strategy. The recently introduced Spatiotemporal Neuroscience suggests that neural activity and subjective experience share a commonly underlying feature as their “common currency”, notably analogous spatiotemporal dynamics. Can Spatiotemporal Neuroscience inform Neurophenomenology to allow for a deeper and more substantiative connection of first-person experience and third-person neural activity? The goal of our paper is to show how Spatiotemporal Neuroscience and Neurophenomenology can be converged and integrated with each other to gain better understanding of the brain-mind connection. We describe their convergence on theoretical grounds which, subsequently, is illustrated by empirical examples like self, meditation, and depression. In conclusion, we propose that the integration of Neurophenomenology and Spatiotemporal Neuroscience can provide complementary insights, enrich both fields, allows for deeper understanding of brain-mind connection, and opens the door for developing novel methodological approaches in their empirical investigation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106139"},"PeriodicalIF":7.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analyses of executive function deficits in chemotherapy-treated rodent models 化疗啮齿动物模型执行功能缺陷的元分析。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-05 DOI: 10.1016/j.neubiorev.2025.106131

Weiye Chen, Ian N. Johnston

{"title":"Meta-analyses of executive function deficits in chemotherapy-treated rodent models","authors":"Weiye Chen, Ian N. Johnston","doi":"10.1016/j.neubiorev.2025.106131","DOIUrl":"10.1016/j.neubiorev.2025.106131","url":null,"abstract":"<div><div>People diagnosed with cancer who undergo chemotherapy commonly encounter cognitive changes, particularly in executive functions (EFs). EFs support goal-directed behaviours, with EF deficits implicated in various neurocognitive impairments. We conducted five meta-analyses of the rodent models to investigate the impact of chemotherapy across five EF domains. A systematic search across PubMed, Web of Science, Scopus, and PsycINFO yielded 56 eligible papers. Our findings supported the clinical literature suggesting the selective impact of chemotherapy on different EF domains. Specifically, chemotherapy-treated animals performed significantly more poorly than controls in tasks assessing working memory, behavioural flexibility, and problem-solving, with no significant group differences in inhibition or attention. Subgroup analyses revealed that alkylating agents, antitumor antibiotics, and combination therapies were strongly associated with working memory deficits, whereas mitotic inhibitors were not. Rodent species, strain, age, sex, number of treatments, and time of behavioural assessment since the end of treatment did not moderate the drug effect on any assessed EF domains. To increase the generalisability and translational validity of the results, the overall reporting quality of animal studies needs to be improved with more details on randomisation, blinding, sample sizes, and criteria for animal exclusions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106131"},"PeriodicalIF":7.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Fear and safety learning in anxiety- and stress-related disorders: An updated meta-analysis” [Neurosci. Biobehav. Rev. 169 (2025) 105983] “焦虑和压力相关障碍中的恐惧和安全学习：一项更新的荟萃分析”的更正[神经科学]。Biobehav。Rev. 169(2025) 105983]。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-04 DOI: 10.1016/j.neubiorev.2025.106123

F.M. Kausche, H.P. Carsten, K.M. Sobania, A. Riesel

引用次数: 0

Priors, Evidence, and Memory: Dynamics of Predictive Processing (POEM). 先验、证据与记忆：预测处理的动态。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-03 DOI: 10.1016/j.neubiorev.2025.106137

Sophie Nolden, Oded Bein, Yee Lee Shing

引用次数: 0

Non-neuronal brain biology and its relevance to animal welfare 非神经元大脑生物学及其与动物福利的相关性。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-02 DOI: 10.1016/j.neubiorev.2025.106136

Alistair B. Lawrence , Sarah M. Brown , Barry M. Bradford , Neil A. Mabbott , Vincent Bombail , Kenny M.D. Rutherford

{"title":"Non-neuronal brain biology and its relevance to animal welfare","authors":"Alistair B. Lawrence , Sarah M. Brown , Barry M. Bradford , Neil A. Mabbott , Vincent Bombail , Kenny M.D. Rutherford","doi":"10.1016/j.neubiorev.2025.106136","DOIUrl":"10.1016/j.neubiorev.2025.106136","url":null,"abstract":"<div><div>Non-neuronal cells constitute a significant portion of brain tissue and are seen as having key roles in brain homeostasis and responses to challenges. This review illustrates how non-neuronal biology can bring new perspectives to animal welfare through understanding mechanisms that determine welfare outcomes and highlighting interventions to improve welfare. Most obvious in this respect is the largely unrecognised relevance of neuroinflammation to animal welfare which is increasingly found to have roles in determining how animals respond to challenges. We start by introducing non-neuronal cells and review their involvement in affective states and cognition often seen as core psychological elements of animal welfare. We find that the evidence for a causal involvement of glia in cognition is currently more advanced than the corresponding evidence for affective states. We propose that translational research on affective disorders could usefully apply welfare science derived approaches for assessing affective states. Using evidence from translational research, we illustrate the involvement of non-neuronal cells and neuroinflammatory processes as mechanisms modulating resilience to welfare challenges including disease, pain, and social stress. We review research on impoverished environments and environmental enrichment which suggests that environmental conditions which improve animal welfare also improve resilience to challenges through balancing pro- and anti-inflammatory non-neuronal processes. We speculate that non-neuronal biology has relevance to animal welfare beyond neuro-inflammation including facilitating positive affective states. We acknowledge the relevance of neuronal biology to animal welfare whilst proposing that non-neuronal biology provides additional and relevant insights to improve animals’ lives.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106136"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models 神经可塑性和致幻剂：经典和非经典化合物在前和临床模型的综合检查

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-02 DOI: 10.1016/j.neubiorev.2025.106132

Claudio Agnorelli , Meg Spriggs , Kate Godfrey , Gabriela Sawicka , Bettina Bohl , Hannah Douglass , Andrea Fagiolini , Hashemi Parastoo , Robin Carhart-Harris , David Nutt , David Erritzoe

{"title":"Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models","authors":"Claudio Agnorelli , Meg Spriggs , Kate Godfrey , Gabriela Sawicka , Bettina Bohl , Hannah Douglass , Andrea Fagiolini , Hashemi Parastoo , Robin Carhart-Harris , David Nutt , David Erritzoe","doi":"10.1016/j.neubiorev.2025.106132","DOIUrl":"10.1016/j.neubiorev.2025.106132","url":null,"abstract":"<div><div>Neuroplasticity, the ability of the nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment target for neuropsychiatric conditions. Psychedelics, a burgeoning category of drugs, are increasingly prominent in psychiatric research, prompting inquiries into their mechanisms of action. Distinguishing themselves from traditional medications, psychedelics demonstrate rapid and enduring therapeutic effects after a single or few administrations, believed to stem from their neuroplasticity-enhancing properties. This review examines how classic psychedelics (e.g., LSD, psilocybin, N,N-DMT) and non-classic psychedelics (e.g., ketamine, MDMA) influence neuroplasticity. Drawing from preclinical and clinical studies, we explore the molecular, structural, and functional changes triggered by these agents. Animal studies suggest psychedelics induce heightened sensitivity of the nervous system to environmental stimuli (meta-plasticity), re-opening developmental windows for long-term structural changes (hyper-plasticity), with implications for mood and behavior. Translating these findings to humans faces challenges due to limitations in current imaging techniques. Nonetheless, promising new directions for human research are emerging, including the employment of novel positron-emission tomography (PET) radioligands, non-invasive brain stimulation methods, and multimodal approaches. By elucidating the interplay between psychedelics and neuroplasticity, this review informs the development of targeted interventions for neuropsychiatric disorders and advances understanding of psychedelics' therapeutic potential.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"172 ","pages":"Article 106132"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Priors, evidence, and memory: Dynamics of predictive processing in a hierarchical visual system 先验、证据和记忆：分层视觉系统中的预测处理动态。

IF 7.5 1区医学

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-02 DOI: 10.1016/j.neubiorev.2025.106134

Lars F. Muckli

引用次数: 0