Mating duration of male Drosophila melanogaster – A novel genetic model to study interval timing function of human brain

Time perception is essential for survival, enabling animals to estimate and control intervals between events, which underlies complex behaviors. While the brain efficiently processes temporal information across various timescales, the neural and genetic mechanisms governing this ability remain poorly understood. Although research has identified brain regions involved in timing information, genetic exploration of temporal perception lags behind, particularly outside circadian rhythms. Advances in neuroscience now allow genetic manipulation of neurotransmitters and neuropeptides to study neural circuits, but a comprehensive understanding of the molecular basis of timing remains elusive. This gap persists due to the lack of a model system that integrates behavioral, neural, and genetic data. In this context, we propose male mating duration as a novel interval timing model, as it provides a unique framework to study the interplay between genetic factors and temporal processing. Establishing such a system requires multidisciplinary efforts across computational neuroscience, molecular genetics, and behavioral genetics to uncover unifying principles of timing processes.