发布求助
文献互助 智能选刊 最新文献

Trends in Cell Biology最新文献

筛选
英文 中文
Metabolic control of replisome plasticity in genome surveillance.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-12 DOI: 10.1016/j.tcb.2025.01.006
Mikkel Bo Petersen, Gita Chhetri, Kumar Somyajit
{"title":"Metabolic control of replisome plasticity in genome surveillance.","authors":"Mikkel Bo Petersen, Gita Chhetri, Kumar Somyajit","doi":"10.1016/j.tcb.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.006","url":null,"abstract":"<p><p>Metabolic pathways and DNA replication are both adaptable and essential for early development and cancer progression. While each process is well understood individually, the mechanisms coordinating them are just beginning to emerge. Nucleotide biosynthesis serves as a crucial link, with fluctuating nucleotide pools leading to imbalanced deoxyribonucleotide (dNTP) and increased ribonucleotide (rNTP) levels, impairing DNA synthesis and triggering replication stress; ultimately driving developmental disorders and cancer. To counter these challenges, the replisome - the core machinery of DNA replication - continuously adjusts its architecture and speed in response to physiological changes, including nucleotide fluctuations. This review outlines recent insights into how the replisome aligns its function with metabolic changes in nucleotide levels and explores emerging links between metabolism and genome stability, and their roles in development and disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclase-associated protein: an actin regulator with multiple neuronal functions.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-10 DOI: 10.1016/j.tcb.2025.01.007
Marco B Rust, Sharof Khudayberdiev
{"title":"Cyclase-associated protein: an actin regulator with multiple neuronal functions.","authors":"Marco B Rust, Sharof Khudayberdiev","doi":"10.1016/j.tcb.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.007","url":null,"abstract":"<p><p>Studies of the past decade established cyclase-associated protein (CAP) as a key regulator of actin dynamics and associated its dysregulation with human brain disorders. However, its neuronal functions remained unknown until recent studies deciphered CAP-dependent mechanisms relevant for neuron differentiation or synapse morphogenesis, which are summarized and discussed in this forum article.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-07 DOI: 10.1016/j.tcb.2025.01.003
Michael J Clague, Sylvie Urbé
{"title":"Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import.","authors":"Michael J Clague, Sylvie Urbé","doi":"10.1016/j.tcb.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.003","url":null,"abstract":"<p><p>The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are strongly linked to mitochondrial dysfunction and hypoxia, respectively. Both are regulated by ubiquitylation and mitochondrial import. Recent studies have elucidated how the ubiquitin kinase PINK1 acts as a sensor of mitochondrial import stress through stable interaction with a mitochondrial import supercomplex. The stability of BNIP3 and NIX is regulated by the SCF<sup>FBXL4</sup> ubiquitin ligase complex. Substrate recognition requires an adaptor molecule, PPTC7, whose availability is limited by mitochondrial import. Unravelling the functional implications of each mode of mitophagy remains a critical challenge. We propose that mitochondrial import stress prompts a switch between these two pathways.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-04 DOI: 10.1016/j.tcb.2025.01.002
Shuangcheng Alivia Wu, Zexin Jason Li, Ling Qi
{"title":"Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.","authors":"Shuangcheng Alivia Wu, Zexin Jason Li, Ling Qi","doi":"10.1016/j.tcb.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.002","url":null,"abstract":"<p><p>Protein misfolding and aggregation in the endoplasmic reticulum (ER) have been causally linked to a variety of human diseases. Two key pathways for eliminating misfolded proteins and aggregates in the ER are ER-associated degradation (ERAD) and ER-phagy, respectively. While both pathways have been well characterized biochemically, our understanding of their physiological relevance and significance remains limited. In recent years, significant advances have been made, including the generation and characterization of various knockout and knockin mouse models, the identification of human disease-associated or -causing variants, and insights into the coordination between ERAD and autophagy in physiological contexts. In this review, we summarize these advancements, highlighting the key roles of a highly conserved suppressor of lin-12-like-hydroxymethyl glutaryl-coenzyme A reductase degradation 1 (SEL1L-HRD1) protein complex of ERAD and ER-phagy in health and disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhythmic forces shaping the zebrafish cardiac system. 形成斑马鱼心脏系统的节律力。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.tcb.2024.10.012
Hajime Fukui, Renee Wei-Yan Chow, Choon Hwai Yap, Julien Vermot
{"title":"Rhythmic forces shaping the zebrafish cardiac system.","authors":"Hajime Fukui, Renee Wei-Yan Chow, Choon Hwai Yap, Julien Vermot","doi":"10.1016/j.tcb.2024.10.012","DOIUrl":"10.1016/j.tcb.2024.10.012","url":null,"abstract":"<p><p>The structural development of the heart depends heavily on mechanical forces, and rhythmic contractions generate essential physical stimuli during morphogenesis. Cardiac cells play a critical role in coordinating this process by sensing and responding to these mechanical forces. In vivo, cells experience rhythmic spatial and temporal variations in deformation-related stresses throughout heart development. What impact do these mechanical forces have on heart morphogenesis? Recent work in zebrafish (Danio rerio) offers important insights into this question. This review focuses on endocardial (EdCs) and myocardial cells (cardiomyocytes, CMs), key cell types in the heart, and provides a comprehensive overview of forces and tissue mechanics in zebrafish and their direct influence on cardiac cell identity.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"166-176"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of H3K4 methylation in biology and disease. H3K4 甲基化在生物学和疾病中的作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-06-21 DOI: 10.1016/j.tcb.2024.06.001
Hua Wang, Kristian Helin
{"title":"Roles of H3K4 methylation in biology and disease.","authors":"Hua Wang, Kristian Helin","doi":"10.1016/j.tcb.2024.06.001","DOIUrl":"10.1016/j.tcb.2024.06.001","url":null,"abstract":"<p><p>Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease. In this review, we focus on recent studies that have yielded insights into how levels and patterns of H3K4me3 are regulated, how H3K4me3 contributes to the regulation of specific phases of transcription such as RNA polymerase II initiation, pause-release, heterogeneity, and consistency. The conclusion from these studies is that H3K4me3 by itself regulates gene expression and its precise regulation is essential for normal development and preventing disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"115-128"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins. 羟基类固醇脱氢酶蛋白对脂滴动力学和脂质稳态的调控
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI: 10.1016/j.tcb.2024.10.010
Bin Liang, Lin Fu, Pingsheng Liu
{"title":"Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins.","authors":"Bin Liang, Lin Fu, Pingsheng Liu","doi":"10.1016/j.tcb.2024.10.010","DOIUrl":"10.1016/j.tcb.2024.10.010","url":null,"abstract":"<p><p>The superfamily of hydroxysteroid dehydrogenases (HSDs) has been well-characterized as enzymes in lipid metabolism, and especially in steroid hormone metabolism from bacteria to mammals. Recently, a subset of HSDs members, including 3β-HSD, 11β-HSD, and 17β-HSD, have been shown to be lipid droplet (LD)-associated proteins that are involved in LD dynamics beyond their canonical functions. This review summarizes current understanding of these LD-associated HSD proteins, focusing on how they regulate different LDs with respect to distinct neutral lipids including triacylglycerols (TAGs), cholesterol esters (CEs), and retinyl esters (REs), the evolutionally conserved role of some LD-associated 17β-HSDs in preventing lipolysis, and specific targeting of HSDs for the treatment of metabolic diseases and viral infections.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"153-165"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper and iron orchestrate cell-state transitions in cancer and immunity. 铜和铁协调癌症和免疫中的细胞状态转变
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-07-29 DOI: 10.1016/j.tcb.2024.07.005
Sebastian Müller, Tatiana Cañeque, Stéphanie Solier, Raphaël Rodriguez
{"title":"Copper and iron orchestrate cell-state transitions in cancer and immunity.","authors":"Sebastian Müller, Tatiana Cañeque, Stéphanie Solier, Raphaël Rodriguez","doi":"10.1016/j.tcb.2024.07.005","DOIUrl":"10.1016/j.tcb.2024.07.005","url":null,"abstract":"<p><p>Whereas genetic mutations can alter cell properties, nongenetic mechanisms can drive rapid and reversible adaptations to changes in their physical environment, a phenomenon termed 'cell-state transition'. Metals, in particular copper and iron, have been shown to be rate-limiting catalysts of cell-state transitions controlling key chemical reactions in mitochondria and the cell nucleus, which govern metabolic and epigenetic changes underlying the acquisition of distinct cell phenotypes. Acquisition of a distinct cell identity, independently of genetic alterations, is an underlying phenomenon of various biological processes, including development, inflammation, erythropoiesis, aging, and cancer. Here, mechanisms that have been uncovered related to the role of these metals in the regulation of cell plasticity are described, illustrating how copper and iron can be exploited for therapeutic intervention.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"105-114"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Filopodia: integrating cellular functions with theoretical models. 丝状体：细胞功能与理论模型的结合。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1016/j.tcb.2024.05.005
Victoria Thusgaard Ruhoff, Natascha Leijnse, Amin Doostmohammadi, Poul Martin Bendix
{"title":"Filopodia: integrating cellular functions with theoretical models.","authors":"Victoria Thusgaard Ruhoff, Natascha Leijnse, Amin Doostmohammadi, Poul Martin Bendix","doi":"10.1016/j.tcb.2024.05.005","DOIUrl":"10.1016/j.tcb.2024.05.005","url":null,"abstract":"<p><p>Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell-cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"129-140"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Universities should standardize faculty application process.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2025-01-06 DOI: 10.1016/j.tcb.2024.12.003
Kif Liakath-Ali
{"title":"Universities should standardize faculty application process.","authors":"Kif Liakath-Ali","doi":"10.1016/j.tcb.2024.12.003","DOIUrl":"10.1016/j.tcb.2024.12.003","url":null,"abstract":"<p><p>Building a faculty job application package is a crucial step for academic career advancement, yet early career researchers (ECRs) often face significant time and emotional challenges during this process. The varying application systems across institutions create unnecessary complexity and waste time. Standardizing these procedures would save time, reduce burdens, and enhance fairness in recruitment.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":"35 2","pages":"89-91"},"PeriodicalIF":13.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信