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POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer. POGK 是一种驯化的含 KRAB 结构域的转座元件，在乳腺癌中具有肿瘤抑制功能。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-14 DOI: 10.1016/j.tcb.2024.11.002
Karen M Mann
{"title":"POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer.","authors":"Karen M Mann","doi":"10.1016/j.tcb.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.11.002","url":null,"abstract":"<p><p>Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central role of the ER proteostasis network in healthy aging. ER蛋白稳态网络在健康老龄化中的核心作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-14 DOI: 10.1016/j.tcb.2024.10.003
Claudio Hetz, Andrew Dillin
{"title":"Central role of the ER proteostasis network in healthy aging.","authors":"Claudio Hetz, Andrew Dillin","doi":"10.1016/j.tcb.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.003","url":null,"abstract":"<p><p>Aging trajectories vary among individuals, characterized by progressive functional decline, often leading to disease states. One of the central hallmarks of aging is the deterioration of proteostasis, where the function of the endoplasmic reticulum (ER) is dramatically affected. ER stress is monitored and adjusted by the unfolded protein response (UPR); a signaling pathway that mediates adaptive processes to restore proteostasis. Studies in multiple model organisms (yeast, worms, flies, and mice) in addition to human tissue indicates that adaptive UPR signaling contributes to healthy aging. Strategies to improve ER proteostasis using small molecules and gene therapy reduce the decline of organ function during normal aging in mammals. This article reviews recent advances in understanding the significance of the ER proteostasis network to normal aging and its relationship with other hallmarks of aging such as senescence.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TFEB links the cGAS-STING pathway to lysosome biogenesis. TFEB 将 cGAS-STING 通路与溶酶体生物生成联系起来。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-14 DOI: 10.1016/j.tcb.2024.10.011
Yaping Meng, Xinran Li, Haoxing Xu
{"title":"TFEB links the cGAS-STING pathway to lysosome biogenesis.","authors":"Yaping Meng, Xinran Li, Haoxing Xu","doi":"10.1016/j.tcb.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.011","url":null,"abstract":"<p><p>The cGAS-STING pathway senses the level of double-stranded (ds)DNA in the cytosol, and is required for innate immunity through its effector, TBK1. A recent study by Lv et al. reports that STING activation also simultaneously promotes lysosomal biogenesis by inducing nuclear translocation of the transcription factors TFEB/TFE3 independent of TBK1.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The culture and application of circulating tumor cell-derived organoids. 循环肿瘤细胞衍生有机体的培养和应用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-09 DOI: 10.1016/j.tcb.2024.10.004
Can Pan, Xueping Wang, Chuan Yang, Kai Fu, Fang Wang, Liwu Fu
{"title":"The culture and application of circulating tumor cell-derived organoids.","authors":"Can Pan, Xueping Wang, Chuan Yang, Kai Fu, Fang Wang, Liwu Fu","doi":"10.1016/j.tcb.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.004","url":null,"abstract":"<p><p>Circulating tumor cells (CTCs), which have the heterogeneity and histological properties of the primary tumor and metastases, are shed from the primary tumor and/or metastatic lesions into the vasculature and initiate metastases at remote sites. In the clinic, CTCs are used extensively in liquid biopsies for early screening, diagnosis, treatment, and prognosis. Current research focuses on using CTC-derived models to study tumor heterogeneity and metastasis, with 3D organoids emerging as a promising tool in cancer research and precision oncology. However, isolating and enriching CTCs from blood remains challenging due to their scarcity, exacerbated by the lack of an optimized culture medium for CTC-derived organoids (CTCDOs). In this review, we summarize the origin, isolation, enrichment, culture, validation, and clinical application of CTCs and CTCDOs.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of palmitoylation in pyroptosis. 棕榈酰化在高温变态反应中的新作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-08 DOI: 10.1016/j.tcb.2024.10.005
Na Zhang, Yuanxin Yang, Daichao Xu
{"title":"Emerging roles of palmitoylation in pyroptosis.","authors":"Na Zhang, Yuanxin Yang, Daichao Xu","doi":"10.1016/j.tcb.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.005","url":null,"abstract":"<p><p>Pyroptosis is a lytic, proinflammatory type of programmed cell death crucial for the immune response to pathogen infections and internal danger signals. Gasdermin D (GSDMD) acts as the pore-forming protein in pyroptosis following inflammasome activation. While recent research has improved our understanding of pyroptosis activation and execution, many aspects regarding the molecular mechanisms controlling inflammasome and GSDMD activation remain to be elucidated. A growing body of literature has shown that S-palmitoylation, a reversible post-translational modification (PTM) that attaches palmitate to cysteine residues, contributes to multi-layered regulation of pyroptosis. This review summarizes the emerging roles of S-palmitoylation in pyroptosis research with a focus on mechanisms that regulate NLRP3 inflammasome and GSDMD activation.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MDM4 exon skipping upon dysfunctional ribosome assembly. 核糖体组装失调时的 MDM4 外显子跳转。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-07 DOI: 10.1016/j.tcb.2024.10.006
Jennifer Jansen, Matthias Dobbelstein
{"title":"MDM4 exon skipping upon dysfunctional ribosome assembly.","authors":"Jennifer Jansen, Matthias Dobbelstein","doi":"10.1016/j.tcb.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.006","url":null,"abstract":"<p><p>Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22). Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53. This forum article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate decisions.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation. 在病理生理细胞激活过程中，O-GlcNAcylation 的增加将代谢与转录重编程联系起来。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-07 DOI: 10.1016/j.tcb.2024.10.007
Ninon Very, Bart Staels, Jérôme Eeckhoute
{"title":"Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation.","authors":"Ninon Very, Bart Staels, Jérôme Eeckhoute","doi":"10.1016/j.tcb.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.007","url":null,"abstract":"<p><p>Increased protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) has emerged as a hallmark of mammalian cell activation, contributing to Warburg-like metabolic rewiring allowing the acquisition of new functionalities. Recent advances indicate that O-GlcNAcylation promotes the activity of transcriptional regulators driving gene expression reprogramming. This may offer new therapeutic opportunities in a broad spectrum of pathological conditions.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic rRNA modifications as a source of ribosome heterogeneity. 动态 rRNA 修饰是核糖体异质性的来源。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-04 DOI: 10.1016/j.tcb.2024.10.001
Ivan Milenkovic, Eva Maria Novoa
{"title":"Dynamic rRNA modifications as a source of ribosome heterogeneity.","authors":"Ivan Milenkovic, Eva Maria Novoa","doi":"10.1016/j.tcb.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.10.001","url":null,"abstract":"<p><p>Ribosomal RNAs (rRNA) are the most abundant RNA molecules in almost all cell types. The general consensus in the field is that rRNA modifications are largely species-specific, with most previous works and databases solely stratifying modifications by the species of origin, without taking other levels of complexity into account. However, new evidence has emerged suggesting dynamic rRNA modifications may have additional layers of complexity and might play an important role in development and disease. In this review article, we summarize recent evidence supporting heterogeneity and dynamics in rRNA modifications in diverse biological contexts, challenging the simplistic view of 'one-species-one-rRNA-modification-pattern'. Moreover, we highlight how rRNA modification dynamics have been studied to date and how long-read sequencing methods can significantly improve our understanding of this largely unexplored yet highly abundant RNA family, across tissues, developmental stages, and diseases.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing is everything: advances in quantifying splicing kinetics. 时间就是一切：量化剪接动力学的进展。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tcb.2024.03.007
Hope E Merens, Karine Choquet, Autum R Baxter-Koenigs, L Stirling Churchman
{"title":"Timing is everything: advances in quantifying splicing kinetics.","authors":"Hope E Merens, Karine Choquet, Autum R Baxter-Koenigs, L Stirling Churchman","doi":"10.1016/j.tcb.2024.03.007","DOIUrl":"10.1016/j.tcb.2024.03.007","url":null,"abstract":"<p><p>Splicing is a highly regulated process critical for proper pre-mRNA maturation and the maintenance of a healthy cellular environment. Splicing events are impacted by ongoing transcription, neighboring splicing events, and cis and trans regulatory factors on the respective pre-mRNA transcript. Within this complex regulatory environment, splicing kinetics have the potential to influence splicing outcomes but have historically been challenging to study in vivo. In this review, we highlight recent technological advancements that have enabled measurements of global splicing kinetics and of the variability of splicing kinetics at single introns. We demonstrate how identifying features that are correlated with splicing kinetics has increased our ability to form potential models for how splicing kinetics may be regulated in vivo.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"968-981"},"PeriodicalIF":13.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytoplasmic mtDNA clearance suppresses inflammatory immune responses. 细胞质 mtDNA 清除抑制炎症免疫反应。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-11-01 Epub Date: 2024-10-07 DOI: 10.1016/j.tcb.2024.09.002
Chenghao Yan, Xu Liu, Haodong Xu, Liming Wang
{"title":"Cytoplasmic mtDNA clearance suppresses inflammatory immune responses.","authors":"Chenghao Yan, Xu Liu, Haodong Xu, Liming Wang","doi":"10.1016/j.tcb.2024.09.002","DOIUrl":"10.1016/j.tcb.2024.09.002","url":null,"abstract":"<p><p>Upon various stresses, mtDNA leaks from mitochondria into the cytoplasm, leading to cellular dysfunction and inflammation, thereby exacerbating disease progression. The autophagy-lysosome pathway has emerged as a pivotal quality control mechanism for eliminating abnormal cytoplasmic mtDNA. This article summarizes the mechanisms underlying mtDNA-triggered inflammation and how cytoplasmic mtDNA is eliminated.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"897-900"},"PeriodicalIF":13.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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