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How are mitochondrial nucleoids trafficked?
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI: 10.1016/j.tcb.2024.12.007
Josefa Macuada, Isidora Molina-Riquelme, Verónica Eisner
{"title":"How are mitochondrial nucleoids trafficked?","authors":"Josefa Macuada, Isidora Molina-Riquelme, Verónica Eisner","doi":"10.1016/j.tcb.2024.12.007","DOIUrl":"10.1016/j.tcb.2024.12.007","url":null,"abstract":"<p><p>Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (IMM), according to the 'sphere of influence' theory. mtDNA is compacted into nucleoids, which are tethered to the IMM and distributed throughout the mitochondrial network. Some nucleoid subpopulations present distinct intramitochondrial positioning during fission and their correct positioning is associated with mtDNA segregation and selective degradation. This opinion article focuses on different mechanisms that could control nucleoid positioning through intramitochondrial trafficking, either by cristae reshaping or by intercompartment-driven mechanisms involving the mitochondrial membranes and extramitochondrial elements. Understanding nucleoid trafficking promises insights into mitochondrial dysfunction in pathologies with mtDNA distribution and segregation issues.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"194-204"},"PeriodicalIF":13.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting YTHDF2 impacts the epitranscriptome and overcomes tumor therapy resistance.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI: 10.1016/j.tcb.2025.02.003
Zhicong Zhao, Li Han, Qiwei Ge
{"title":"Targeting YTHDF2 impacts the epitranscriptome and overcomes tumor therapy resistance.","authors":"Zhicong Zhao, Li Han, Qiwei Ge","doi":"10.1016/j.tcb.2025.02.003","DOIUrl":"10.1016/j.tcb.2025.02.003","url":null,"abstract":"<p><p>Dysregulation of RNA modifiers is common across cancer types and has essential roles in tumor therapy resistance. Chen and colleagues reported that YTHDF2 played dual roles in B cell malignancies by enhancing cell proliferation and promoting immune evasion. Targeting YTHDF2 with inhibitors offers an approach to tumor treatment by regulating the epitranscriptome.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"177-179"},"PeriodicalIF":13.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and future perspectives of lysine lactylation in cancer. 赖氨酸乳酸化在癌症中的现状和未来展望。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-03-01 Epub Date: 2025-01-20 DOI: 10.1016/j.tcb.2024.12.015
Sijia Li, Lixia Dong, Kui Wang
{"title":"Current and future perspectives of lysine lactylation in cancer.","authors":"Sijia Li, Lixia Dong, Kui Wang","doi":"10.1016/j.tcb.2024.12.015","DOIUrl":"10.1016/j.tcb.2024.12.015","url":null,"abstract":"<p><p>Lactate, a glycolytic intermediate, has a crucial role in cancer metabolism and microenvironment remodeling. Recently, researchers found that lactate mediates lysine lactylation, a novel protein post-translational modification (PTM). Here, we summarize the mechanism and role of lysine lactylation in cancer, and discuss the potential of targeting lysine lactylation in cancer therapy.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"190-193"},"PeriodicalIF":13.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate. 肿瘤微环境中细胞外囊泡介导的串扰主导着肿瘤的命运。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.1016/j.tcb.2024.08.008
Xinyu Dou, Chunyu Feng, Ji Li, Erhui Jiang, Zhengjun Shang
{"title":"Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate.","authors":"Xinyu Dou, Chunyu Feng, Ji Li, Erhui Jiang, Zhengjun Shang","doi":"10.1016/j.tcb.2024.08.008","DOIUrl":"10.1016/j.tcb.2024.08.008","url":null,"abstract":"<p><p>The tumor microenvironment (TME) is a complex and heterogeneous system containing various cells cooperating and competing with each other. Extracellular vesicles (EVs) differing in form and content are important intercellular communication mediators in the TME. Previous studies have focused on the cargoes within EVs rather than on the donors from which they originate and the recipient cells that exert their effects. Therefore, we provide here a detailed overview of the important roles of EVs in shaping tumor fate, highlighting their various mechanisms of intercellular dialog within the TME. We evaluate recent advances and also raise unresolved challenges to provide new ideas for clinical treatment strategies using EVs.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"230-247"},"PeriodicalIF":13.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The migrasome, an organelle for cell-cell communication. 移行体，一种用于细胞间通讯的细胞器。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-03-01 Epub Date: 2024-06-11 DOI: 10.1016/j.tcb.2024.05.003
Dong Jiang, Jinzhao He, Li Yu
{"title":"The migrasome, an organelle for cell-cell communication.","authors":"Dong Jiang, Jinzhao He, Li Yu","doi":"10.1016/j.tcb.2024.05.003","DOIUrl":"10.1016/j.tcb.2024.05.003","url":null,"abstract":"<p><p>Migrasomes, newly identified extracellular organelles produced by migrating cells, are observed widely across both in vivo and in vitro studies. These organelles, rich in signaling and bioactive molecules, are pivotal in a range of physiological functions. This opinion summarizes current understanding of migrasomes, highlighting their importance as a versatile mechanism for cell-cell communication. Furthermore, it examines their roles in health and disease and potential diagnostic and therapeutic applications, and addresses the emerging challenges and open questions in this developing field.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"205-216"},"PeriodicalIF":13.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding melanoma's cellular mosaic to unlock immunotherapy potential.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-28 DOI: 10.1016/j.tcb.2025.01.009
Joanna Pozniak, Jean-Christophe Marine
{"title":"Decoding melanoma's cellular mosaic to unlock immunotherapy potential.","authors":"Joanna Pozniak, Jean-Christophe Marine","doi":"10.1016/j.tcb.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.009","url":null,"abstract":"<p><p>Cancer evolution is driven by molecular events within cancer cells and their complex interactions with surrounding cells. Intra-tumor heterogeneity - driven by somatic genetic mutations, epigenetic dysregulation, immune cell infiltration, and microenvironmental factors - complicates the identification of reliable biomarkers and therapeutic targets. Single-cell sequencing and spatial multiomics technologies are revolutionizing our comprehension of how each component of the cellular machinery and tissue architecture collaborates to propel cancer progression. Much like how the restoration and interpretation of Pompeii mosaics have enriched our understanding of ancient Roman life, unraveling the intricate mosaic of cancer will transform the way this disease is diagnosed and treated. This review describes how the advent of single-cell multiomics has provided crucial insights into cutaneous melanoma biology and the mechanisms underlying resistance to immunotherapy.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-25 DOI: 10.1016/j.tcb.2025.02.004
Woo Yong Park, Claudia Montufar, Elma Zaganjor
{"title":"Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes.","authors":"Woo Yong Park, Claudia Montufar, Elma Zaganjor","doi":"10.1016/j.tcb.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.02.004","url":null,"abstract":"<p><p>Mitochondrial metabolism, signaling, and dynamics are key regulators of cell fate. While glycolysis supports stemness, mitochondrial expansion and oxidative phosphorylation (OXPHOS) facilitate differentiation. This forum presents emerging evidence that the type of substrate, whether amino acids, carbohydrates, or fatty acids, oxidized by mitochondria significantly influences differentiation outcomes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase separation of p62: roles and regulations in autophagy.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-25 DOI: 10.1016/j.tcb.2025.01.010
Xue Huang, Jinpei Zhang, Jia Yao, Na Mi, Aimin Yang
{"title":"Phase separation of p62: roles and regulations in autophagy.","authors":"Xue Huang, Jinpei Zhang, Jia Yao, Na Mi, Aimin Yang","doi":"10.1016/j.tcb.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.010","url":null,"abstract":"<p><p>The phase separation of the cargo receptor sequestome-1/p62 (SQSTM1/p62) is a critical mechanism for assembling signaling complexes in autophagy. During this process, p62 undergoes phase separation upon binding to polyubiquitin chains, concentrating ubiquitinated substrates within p62 droplets. These droplets further gather membrane sources and core autophagy machineries to facilitate autophagosome formation. The dynamics of p62 droplets are finely tuned in response to autophagy signals triggered by cellular stresses. Recent studies have revealed new regulatory mechanisms that highlight the significance of p62 phase separation in regulating autophagy. This review summarizes and discusses the molecular mechanisms of p62 phase separation and its roles in autophagy, with particular emphasis on the regulation of p62 droplets and their interaction modes with autophagic membranes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ER-mitochondria contact sites: a refuge for mitochondrial mRNAs under ER stress.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-25 DOI: 10.1016/j.tcb.2025.02.002
Philippe Pihán, Lisa M Ellerby, Claudio Hetz
{"title":"ER-mitochondria contact sites: a refuge for mitochondrial mRNAs under ER stress.","authors":"Philippe Pihán, Lisa M Ellerby, Claudio Hetz","doi":"10.1016/j.tcb.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.02.002","url":null,"abstract":"<p><p>Tight mitochondria-endoplasmic reticulum (ER) contacts (MERCS) play essential roles in cellular homeostasis. Brar et al. reveal a novel mechanism where mitochondrial mRNAs escape global translational repression at novel context-specific MERCS during ER stress, uncovering spatially regulated translation as a critical adaptive strategy to cope with cellular stress.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pericentromeric sequences, where a conservation paradox occurs.
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-02-25 DOI: 10.1016/j.tcb.2025.01.011
Runze Ma, Bing Zhu
{"title":"Pericentromeric sequences, where a conservation paradox occurs.","authors":"Runze Ma, Bing Zhu","doi":"10.1016/j.tcb.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.01.011","url":null,"abstract":"<p><p>Pericentromeric sequences are characterized by their tandem repeat structure, heterochromatinization, and rapid evolution. The rapid evolvement creates highly diversified pericentromeric sequences, which facilitate reproductive isolation, as best exemplified in Drosophila studies. Despite their high variability, pericentromeric sequences ranging from fission yeast to humans are heterochromatinized with the same histone modification, H3K9 methylation. These features present a paradox, how highly variable sequences get recognized by conserved machineries. This Opinion discusses how this paradox is resolved and how diversification and conservation get unified at pericentromeric sequences.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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