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Innate versus adoptive competence: the controlled distribution of signalling receptors extends the concept of competence. 先天与适应性能力：信号受体的控制分布扩展了能力的概念。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-01-06 DOI: 10.1016/j.tcb.2024.12.005
Jessica L Bamsey, Lucy Brunt, Steffen Scholpp
{"title":"Innate versus adoptive competence: the controlled distribution of signalling receptors extends the concept of competence.","authors":"Jessica L Bamsey, Lucy Brunt, Steffen Scholpp","doi":"10.1016/j.tcb.2024.12.005","DOIUrl":"10.1016/j.tcb.2024.12.005","url":null,"abstract":"<p><p>Cellular communication through the dissemination of signal molecules is vital for tissue organisation and homeostasis. The mechanisms of signal spreading can include binding-protein-assisted transport, long membrane protrusions known as cytonemes, and exovesicles. Recent research indicates that cytonemes and exovesicles can not only transport ligands but also facilitate the regulated distribution of receptors, thereby enabling signal transduction in cells lacking endogenous receptors. This mechanism allows non-responsive cells to temporarily acquire the ability to respond to specific ligands. This review explores our understanding of ligand and receptor dispersal, offering fresh insights into the fundamental concept of cellular competence. Notably, these findings may have significant implications for diseases and their associated therapeutic targets, highlighting the urgency and importance of this research area.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":"35 9","pages":"773-781"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy-dependent versus autophagy-independent ferroptosis. 自噬依赖性与自噬非依赖性铁下垂。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-03-05 DOI: 10.1016/j.tcb.2025.01.005
Ye Zhu, Motoki Fujimaki, David C Rubinsztein
{"title":"Autophagy-dependent versus autophagy-independent ferroptosis.","authors":"Ye Zhu, Motoki Fujimaki, David C Rubinsztein","doi":"10.1016/j.tcb.2025.01.005","DOIUrl":"10.1016/j.tcb.2025.01.005","url":null,"abstract":"<p><p>Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which cell contexts determine the roles of autophagy in ferroptosis. This opinion article addresses this question by summarizing the contexts and/or diseases in which autophagy is a driver or suppressor of ferroptosis. The execution of ferroptosis depends on levels of (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that the cell context in which these three factors and/or their upstream pathways are differentially regulated dictates whether autophagy positively or negatively regulates ferroptosis.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"745-760"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Communicating science in Latin America: insights, challenges, and future directions. 在拉丁美洲传播科学：见解、挑战和未来方向。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.tcb.2025.06.003
Cecilia Rosen
{"title":"Communicating science in Latin America: insights, challenges, and future directions.","authors":"Cecilia Rosen","doi":"10.1016/j.tcb.2025.06.003","DOIUrl":"10.1016/j.tcb.2025.06.003","url":null,"abstract":"<p><p>This article reviews public science communication (SC) in Latin America, highlighting advances and challenges. It emphasizes the need to foster inclusive policies, interdisciplinary approaches, and effective evaluation to enhance public engagement, address social inequalities, and foster informed decision-making. Improving this field would strengthen science-society relationships, benefiting both professional communicators and scientific communities.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"717-719"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the signaling potential of GPI-anchored proteins through lipolytic cleavage. 通过脂溶裂解解锁gpi锚定蛋白的信号潜能。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-01-22 DOI: 10.1016/j.tcb.2024.12.010
Razvan Borza, Elisa Matas-Rico, Anastassis Perrakis, Wouter H Moolenaar
{"title":"Unlocking the signaling potential of GPI-anchored proteins through lipolytic cleavage.","authors":"Razvan Borza, Elisa Matas-Rico, Anastassis Perrakis, Wouter H Moolenaar","doi":"10.1016/j.tcb.2024.12.010","DOIUrl":"10.1016/j.tcb.2024.12.010","url":null,"abstract":"<p><p>Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) regulate numerous biological processes through interaction with signaling effectors at the cell surface. As a unique feature, GPI-APs can be released from their anchors by multi-pass GPI-specific phospholipases (types A2, C, and D) to impact signaling networks, phenotype, and cell fate; however, many questions remain outstanding. Here, we discuss and expand our current understanding of the distinct GPI-specific phospholipases, their substrates, effector pathways, and emerging physiological roles, with a focus on the six-transmembrane ecto-phospholipases GDE2 (GDPD5) and GDE3 (GDPD2). We provide structural insight into their AlphaFold-predicted inner workings, revealing how transmembrane (TM) domain plasticity may enable GPI-anchor binding and hydrolysis. Understanding lipolytic cleavage of GPI-APs adds a new dimension to their signaling capabilities and biological functions.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"732-744"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology. 利用计算模型探索上皮和内皮细胞单层力学生物学。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-01-20 DOI: 10.1016/j.tcb.2024.12.014
Pradeep Keshavanarayana, Raul Aparicio-Yuste, Fabian Spill, Maria Jose Gomez-Benito, Effie E Bastounis
{"title":"Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology.","authors":"Pradeep Keshavanarayana, Raul Aparicio-Yuste, Fabian Spill, Maria Jose Gomez-Benito, Effie E Bastounis","doi":"10.1016/j.tcb.2024.12.014","DOIUrl":"10.1016/j.tcb.2024.12.014","url":null,"abstract":"<p><p>Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Computational models have emerged as powerful tools to elucidate how mechanical cues impact the behavior of these monolayers in health and disease. Herein, the importance of mechanics in regulating ENC and EPC monolayer behavior is established, highlighting similarities and differences in various biological contexts. Concurrently, computational approaches and their importance in accelerating mechanobiology studies are discussed, emphasizing their limitations and suggesting future directions. The aim is to inspire further synergies between cell biologists and modelers, which are crucial for accelerating cell mechanobiology research.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"799-813"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing nanoengineered CAR-T cell strategies to advance solid tumor immunotherapy. 利用纳米工程CAR-T细胞策略推进实体瘤免疫治疗。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2024-12-24 DOI: 10.1016/j.tcb.2024.11.010
Xiaoxiao Wang, Rangrang Fan, Min Mu, Liangxue Zhou, Bingwen Zou, Aiping Tong, Gang Guo
{"title":"Harnessing nanoengineered CAR-T cell strategies to advance solid tumor immunotherapy.","authors":"Xiaoxiao Wang, Rangrang Fan, Min Mu, Liangxue Zhou, Bingwen Zou, Aiping Tong, Gang Guo","doi":"10.1016/j.tcb.2024.11.010","DOIUrl":"10.1016/j.tcb.2024.11.010","url":null,"abstract":"<p><p>The efficacy and safety of chimeric antigen receptor (CAR) T cell therapy is still inconclusive in solid tumor treatment. Recently, nanotechnology has emerged as a potent strategy to reshape CAR-T cell therapy with promising outcomes. This review aims to discuss the significant potential of nano-engineered CAR-T cell therapy in addressing existing challenges, including CAR-T cell engineering evolution, tumor microenvironment (TME) modulation, and precise CAR-T cell therapy (precise targeting, monitoring, and activation), under the main consideration of clinical translation. It also focuses on the growing trend of technological convergence within this domain, such as mRNA therapeutics, organoids, neoantigen, and artificial intelligence. Moreover, safety management of nanomedicine is seriously emphasized to facilitate clinical translation.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"782-798"},"PeriodicalIF":18.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polysome sorting controls mRNA localization and protein fate. 多聚体分选控制mRNA定位和蛋白质命运。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-08-30 DOI: 10.1016/j.tcb.2025.08.005
Adham Safieddine, Jonathan Bizarro, Soha Salloum, Hervé Le Hir, Edouard Bertrand
{"title":"Polysome sorting controls mRNA localization and protein fate.","authors":"Adham Safieddine, Jonathan Bizarro, Soha Salloum, Hervé Le Hir, Edouard Bertrand","doi":"10.1016/j.tcb.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.08.005","url":null,"abstract":"<p><p>RNA localization and local translation are widespread phenomena that play key roles in a plethora of cellular processes ranging from embryo patterning to general cellular functions. The traditional paradigm assigns localization elements to cis-acting RNA sequences which assemble into complexes that regulate mRNA transport and translation, and the mRNA is generally transported while remaining translationally silent. However, recent evidence has shown that the nascent protein can also play an essential role in RNA localization and can enable polysomes to control their own transport and be delivered where and when they are needed. Two such examples are reviewed: translation factories and centrosomal mRNAs. Their comparison highlights the key role of cotranslational interactions in the spatiotemporal control of protein synthesis and protein fate.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":18.1,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological aging in three dimensions. 三维生理衰老。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-08-30 DOI: 10.1016/j.tcb.2025.08.002
Fei Ma, Ranjan Sen
{"title":"Physiological aging in three dimensions.","authors":"Fei Ma, Ranjan Sen","doi":"10.1016/j.tcb.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.08.002","url":null,"abstract":"<p><p>Aging is characterized by progressive structural and functional decline, driven partially by epigenetic alterations. While changes in DNA methylation, histone modifications, and chromatin accessibility are well studied, the role of three-dimensional chromatin organization in aging remains underexplored. Advances in chromosome conformation capture technologies have revealed hierarchical chromatin structures, including compartments, topologically associating domains (TADs), and chromatin loops, which are crucial for gene regulation. Emerging evidence suggests that aging changes these structures, leading to altered gene expression and cellular dysfunction. This review summarizes recent findings on age-associated chromatin reorganization, highlighting its impact on transcription and nuclear architecture. It also compares the roles of 3D chromatin organization in aging and senescence, highlighting shared and distinct features in these biological contexts.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":18.1,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TGF-β signaling as an organismal proteostasis regulator. TGF-β信号作为机体蛋白酶抑制因子。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-08-29 DOI: 10.1016/j.tcb.2025.07.008
Huadong Zhu, Qian Zhang, Ye Tian, Ehud Cohen
{"title":"TGF-β signaling as an organismal proteostasis regulator.","authors":"Huadong Zhu, Qian Zhang, Ye Tian, Ehud Cohen","doi":"10.1016/j.tcb.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.07.008","url":null,"abstract":"<p><p>Various mechanisms act in a coordinated manner to maintain proteostasis in different cellular organelles. Nevertheless, with aging, certain proteins escape proteostasis surveillance, misfold, and aggregate. This process can lead to neurodegeneration. Despite the cellular nature of proteostasis, it is regulated by intertissue communication. How these intertissue signaling mechanisms coordinate proteostasis across the organism is largely obscure. Recent studies unveiled that the transforming growth factor (TGF)-β signaling cascade is an organismal proteostasis regulator. Here, we focus on the known roles of the TGF-β pathway as a coordinator of proteostasis and describe the messengers and biological activities that are controlled by this pathway. We also discuss open questions and highlight the potential clinical relevance of these discoveries.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":18.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Wnt-NAD+ axis in cancer, aging, and tissue regeneration. Wnt-NAD+轴在癌症、衰老和组织再生中的作用。
IF 18.1 1区 生物学
Trends in Cell Biology Pub Date : 2025-08-29 DOI: 10.1016/j.tcb.2025.07.006
Jilian Lamprecht, Sundos Abu Sanad, Anjali P Kusumbe, Shukry J Habib
{"title":"The Wnt-NAD<sup>+</sup> axis in cancer, aging, and tissue regeneration.","authors":"Jilian Lamprecht, Sundos Abu Sanad, Anjali P Kusumbe, Shukry J Habib","doi":"10.1016/j.tcb.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.07.006","url":null,"abstract":"<p><p>The intricate interplay between Wnt signaling and nicotinamide adenine dinucleotide (NAD<sup>+)</sup> biosynthesis has emerged as a crucial axis that influences aging and tissue regeneration. Wnt signaling, a key regulator of cellular proliferation, differentiation, and tissue homeostasis, intersects with NAD<sup>+</sup> metabolism, a cornerstone of cellular energy balance and genomic stability. This relationship is mediated through shared regulatory pathways involving sirtuins, poly(ADP-ribose) polymerases (PARPs), and metabolic enzymes which are sensitive to cellular NAD<sup>+</sup> levels. Dysregulation of either pathway is implicated in cancer, age-related decline, and impaired regenerative capacity. This review consolidates current knowledge of the Wnt-NAD<sup>+</sup> axis and highlights its cooperative roles in maintaining tissue integrity and combating the effects of aging. Furthermore, it explores therapeutic approaches targeting this axis to restore tissue health and enhance the capacity for repair, thereby offering promising avenues for addressing age-associated pathologies.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":18.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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