{"title":"Autophagy-dependent versus autophagy-independent ferroptosis.","authors":"Ye Zhu, Motoki Fujimaki, David C Rubinsztein","doi":"10.1016/j.tcb.2025.01.005","DOIUrl":null,"url":null,"abstract":"<p><p>Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which cell contexts determine the roles of autophagy in ferroptosis. This opinion article addresses this question by summarizing the contexts and/or diseases in which autophagy is a driver or suppressor of ferroptosis. The execution of ferroptosis depends on levels of (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that the cell context in which these three factors and/or their upstream pathways are differentially regulated dictates whether autophagy positively or negatively regulates ferroptosis.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tcb.2025.01.005","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which cell contexts determine the roles of autophagy in ferroptosis. This opinion article addresses this question by summarizing the contexts and/or diseases in which autophagy is a driver or suppressor of ferroptosis. The execution of ferroptosis depends on levels of (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that the cell context in which these three factors and/or their upstream pathways are differentially regulated dictates whether autophagy positively or negatively regulates ferroptosis.
期刊介绍:
Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.