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Inter-membrane control of junctional InsP3 receptors by PIP2. PIP2对结合部InsP3受体的膜间调控。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1016/j.tcb.2024.11.004
Yandong Zhou, Youjun Wang, Donald L Gill
{"title":"Inter-membrane control of junctional InsP<sub>3</sub> receptors by PIP<sub>2</sub>.","authors":"Yandong Zhou, Youjun Wang, Donald L Gill","doi":"10.1016/j.tcb.2024.11.004","DOIUrl":"10.1016/j.tcb.2024.11.004","url":null,"abstract":"<p><p>Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca<sup>2+</sup> signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) reaches across plasma membrane (PM)-endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca<sup>2+</sup> signals mediating a spectrum of fundamental cellular responses.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"1-3"},"PeriodicalIF":13.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique architectural features of mammalian mitochondrial protein synthesis. 哺乳动物线粒体蛋白质合成的独特结构特征。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-06-08 DOI: 10.1016/j.tcb.2024.05.001
Oliver Rackham, Martin Saurer, Nenad Ban, Aleksandra Filipovska
{"title":"Unique architectural features of mammalian mitochondrial protein synthesis.","authors":"Oliver Rackham, Martin Saurer, Nenad Ban, Aleksandra Filipovska","doi":"10.1016/j.tcb.2024.05.001","DOIUrl":"10.1016/j.tcb.2024.05.001","url":null,"abstract":"<p><p>Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique and idiosyncratic features of the mtDNA and its expression machinery that can be specific to different organisms. In animals, the mitochondrial protein synthesis machinery has acquired many new components and mechanisms over evolution. These include several new ribosomal proteins, new stop codons and ways to recognise them, and new mechanisms to deliver nascent proteins into the mitochondrial inner membrane. Here we describe the mitochondrial protein synthesis machinery in mammals and its unique mechanisms of action elucidated to date and highlight the technologies poised to reveal the next generation of discoveries in mitochondrial translation.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"11-23"},"PeriodicalIF":13.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer. POGK 是一种驯化的含 KRAB 结构域的转座元件，在乳腺癌中具有肿瘤抑制功能。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1016/j.tcb.2024.11.002
Karen M Mann
{"title":"POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer.","authors":"Karen M Mann","doi":"10.1016/j.tcb.2024.11.002","DOIUrl":"10.1016/j.tcb.2024.11.002","url":null,"abstract":"<p><p>Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"4-5"},"PeriodicalIF":13.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADAR1: from basic mechanisms to inhibitors. ADAR1：从基本机制到抑制剂。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-07-18 DOI: 10.1016/j.tcb.2024.06.006
Jan Rehwinkel, Parinaz Mehdipour
{"title":"ADAR1: from basic mechanisms to inhibitors.","authors":"Jan Rehwinkel, Parinaz Mehdipour","doi":"10.1016/j.tcb.2024.06.006","DOIUrl":"10.1016/j.tcb.2024.06.006","url":null,"abstract":"<p><p>Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in humans and mice results in profound inflammatory diseases characterised by the spontaneous induction of innate immunity. In cells lacking ADAR1, unedited RNAs activate RNA sensors. These include melanoma differentiation-associated gene 5 (MDA5) that induces the expression of cytokines, particularly type I interferons (IFNs), protein kinase R (PKR), oligoadenylate synthase (OAS), and Z-DNA/RNA binding protein 1 (ZBP1). Immunogenic RNAs 'defused' by ADAR1 may include transcripts from repetitive elements and other long duplex RNAs. Here, we review these recent fundamental discoveries and discuss implications for human diseases. Some tumours depend on ADAR1 to escape immune surveillance, opening the possibility of unleashing anticancer therapies with ADAR1 inhibitors.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"59-73"},"PeriodicalIF":13.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifarious astrocyte-neuron dialog in shaping neural circuit architecture. 塑造神经回路结构的星形胶质细胞与神经元的多重对话
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-01-01 Epub Date: 2024-06-08 DOI: 10.1016/j.tcb.2024.05.002
Khai H Ngoc, Younghyeon Jeon, Jaewon Ko, Ji Won Um
{"title":"Multifarious astrocyte-neuron dialog in shaping neural circuit architecture.","authors":"Khai H Ngoc, Younghyeon Jeon, Jaewon Ko, Ji Won Um","doi":"10.1016/j.tcb.2024.05.002","DOIUrl":"10.1016/j.tcb.2024.05.002","url":null,"abstract":"<p><p>Astrocytes are multifaceted glial cell types that perform structural, functional, metabolic, and homeostatic roles in the brain. Recent studies have revealed mechanisms underlying the diversity of bidirectional communication modes between astrocytes and neurons - the fundamental organizing principle shaping synaptic properties at tripartite synapses. These astrocyte-neuron interactions are critical for the proper functioning of synapses and neural circuits. This review focuses on molecular mechanisms that direct these interactions, highlighting the versatile roles of multiple adhesion-based paths that likely modulate them, often in a context-dependent manner. It also describes how astrocyte-mediated processes go awry in certain brain disorders and provides a timely insight on the pivotal roles of astrocyte-neuron interactions in synaptic integrity and their relevance to understanding and treating neurological disorders.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"74-87"},"PeriodicalIF":13.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley. 非兴奋细胞中的钠通道：超越霍奇金和赫胥黎的强大作用和治疗目标。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-12-31 DOI: 10.1016/j.tcb.2024.11.009
Dmytro V Vasylyev, Chuan-Ju Liu, Stephen G Waxman
{"title":"Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.","authors":"Dmytro V Vasylyev, Chuan-Ju Liu, Stephen G Waxman","doi":"10.1016/j.tcb.2024.11.009","DOIUrl":"10.1016/j.tcb.2024.11.009","url":null,"abstract":"<p><p>Voltage-gated sodium channels (VGSCs) are best known for their role in the generation and propagation of action potentials in neurons, muscle cells, and cardiac myocytes, which have traditionally been labeled as 'excitable'. However, emerging evidence challenges this traditional perspective. It is now clear that VGSCs are also expressed in a broad spectrum of cells outside the neuromuscular realm, where they regulate diverse cellular functions. In this review, we summarize current knowledge on the expression, regulation, and function of VGSCs in non-neuromuscular cells, highlighting their contributions to physiological processes and pathological conditions. Dynamic expression patterns of VGSCs in different cell types, involvement of VGSCs in cellular functions, such as phagocytosis, motility, and cytokine release, and their potential as therapeutic targets for diseases that include inflammatory disorders, osteoarthritis (OA), and cancer, are discussed. This new understanding of VGSCs and their effects on cells outside the neuromuscular realm opens new avenues for research and therapeutic interventions.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulating cell-free DNA biology as the next frontier in liquid biopsies. 调节无细胞DNA生物学是液体活检的下一个前沿。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-12-26 DOI: 10.1016/j.tcb.2024.11.007
Shervin Tabrizi, Carmen Martin-Alonso, Kan Xiong, Sangeeta N Bhatia, Viktor A Adalsteinsson, J Christopher Love
{"title":"Modulating cell-free DNA biology as the next frontier in liquid biopsies.","authors":"Shervin Tabrizi, Carmen Martin-Alonso, Kan Xiong, Sangeeta N Bhatia, Viktor A Adalsteinsson, J Christopher Love","doi":"10.1016/j.tcb.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.11.007","url":null,"abstract":"<p><p>Technical advances over the past two decades have enabled robust detection of cell-free DNA (cfDNA) in biological samples. Yet, higher clinical sensitivity is required to realize the full potential of liquid biopsies. This opinion article argues that to overcome current limitations, the abundance of informative cfDNA molecules - such as circulating tumor DNA (ctDNA) - collected in a sample needs to increase. To accomplish this, new methods to modulate the biological processes that govern cfDNA production, trafficking, and clearance in the body are needed, informed by a deeper understanding of cfDNA biology. Successful development of such methods could enable a major leap in the performance of liquid biopsies and vastly expand their utility across the spectrum of clinical care.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The endoplasmic reticulum as a cradle for virus and extracellular vesicle secretion. 内质网是病毒和细胞外囊泡分泌的摇篮。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-12-26 DOI: 10.1016/j.tcb.2024.11.008
Yonis Bare, Kyra Defourny, Marine Bretou, Guillaume Van Niel, Esther Nolte-'t Hoen, Raphael Gaudin
{"title":"The endoplasmic reticulum as a cradle for virus and extracellular vesicle secretion.","authors":"Yonis Bare, Kyra Defourny, Marine Bretou, Guillaume Van Niel, Esther Nolte-'t Hoen, Raphael Gaudin","doi":"10.1016/j.tcb.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.11.008","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are small membranous carriers of protein, lipid, and nucleic acid cargoes and play a key role in intercellular communication. Recent work has revealed the previously under-recognized participation of endoplasmic reticulum (ER)-associated proteins (ERAPs) during EV secretion, using pathways reminiscent of viral replication and secretion. Here, we present highlights of the literature involving ER/ERAPs in EV biogenesis and propose mechanistic parallels with ERAPs exploited during viral infections. We propose that ERAPs play an active role in the release of EVs and viral particles, and we present views on whether viruses hijack or enhance pre-existing ERAP-dependent secretory machineries or whether they repurpose ERAPs to create new secretory pathways.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing nanoengineered CAR-T cell strategies to advance solid tumor immunotherapy. 利用纳米工程CAR-T细胞策略推进实体瘤免疫治疗。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-12-24 DOI: 10.1016/j.tcb.2024.11.010
Xiaoxiao Wang, Rangrang Fan, Min Mu, Liangxue Zhou, Bingwen Zou, Aiping Tong, Gang Guo
{"title":"Harnessing nanoengineered CAR-T cell strategies to advance solid tumor immunotherapy.","authors":"Xiaoxiao Wang, Rangrang Fan, Min Mu, Liangxue Zhou, Bingwen Zou, Aiping Tong, Gang Guo","doi":"10.1016/j.tcb.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.11.010","url":null,"abstract":"<p><p>The efficacy and safety of chimeric antigen receptor (CAR) T cell therapy is still inconclusive in solid tumor treatment. Recently, nanotechnology has emerged as a potent strategy to reshape CAR-T cell therapy with promising outcomes. This review aims to discuss the significant potential of nano-engineered CAR-T cell therapy in addressing existing challenges, including CAR-T cell engineering evolution, tumor microenvironment (TME) modulation, and precise CAR-T cell therapy (precise targeting, monitoring, and activation), under the main consideration of clinical translation. It also focuses on the growing trend of technological convergence within this domain, such as mRNA therapeutics, organoids, neoantigen, and artificial intelligence. Moreover, safety management of nanomedicine is seriously emphasized to facilitate clinical translation.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-associated changes in transcriptional elongation and their effects on homeostasis. 年龄相关的转录延伸变化及其对体内平衡的影响。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-12-19 DOI: 10.1016/j.tcb.2024.11.005
Argyris Papantonis, Adam Antebi, Linda Partridge, Andreas Beyer
{"title":"Age-associated changes in transcriptional elongation and their effects on homeostasis.","authors":"Argyris Papantonis, Adam Antebi, Linda Partridge, Andreas Beyer","doi":"10.1016/j.tcb.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.11.005","url":null,"abstract":"<p><p>Cellular homeostasis declines with age due to the declining fidelity of biosynthetic processes and the accumulation of molecular damage. Yet, it remains largely elusive how individual processes are affected during aging and what their specific contribution to age-related functional decline is. This review discusses a series of recent publications that has shown that transcription elongation is compromised during aging due to increasing DNA damage, stalling of RNA polymerase II (RNAPII), erroneous transcription initiation in gene bodies, and accelerated RNAPII elongation. Importantly, several of these perturbations likely arise from changes in chromatin organization with age. Thus, taken together, this work establishes a network of interlinked processes contributing to age-related decline in the quantity and quality of RNA production.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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