POGK 是一种驯化的含 KRAB 结构域的转座元件，在乳腺癌中具有肿瘤抑制功能。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-11-14 DOI:10.1016/j.tcb.2024.11.002

Karen M Mann

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引用次数: 0

摘要

可转座元件（TEs）占人类基因组的 50%，具有基因启动子的基本功能。可转座元件的一个子集在正常细胞中表达，而在癌症中则有不同表达，但它们的生物学意义还未得到充分研究。在最近的一篇文章中，Tu 等人描述了具有 KRAB 结构域的表达 TE POGK 的肿瘤抑制功能，以及它与 TRIM28 合作抑制三阴性乳腺癌（TNBC）中核糖体基因转录的功能。

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POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer.

Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.