Endosome-ER contact sites in phagophore formation.

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI:10.1016/j.tcb.2025.07.002

Mengnan Xu, Pingping Wang, Xian-Ping Dong

引用次数: 0

Abstract

Autophagy is a crucial 'self-eating' mechanism used by eukaryotic cells to degrade and recycle cytosolic materials. A recent study by Da Graça et al. reports that the dynamic mobilization of endosome-endoplasmic reticulum (ER) contact sites (EERCS) in response to starvation creates a confined environment that facilitates Ca²⁺-dependent phagophore biogenesis.

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吞噬体形成中的内核体-内质网接触位点。

自噬是真核细胞降解和循环利用胞质物质的一种重要的“自噬”机制。Da grarada等人最近的一项研究报告称，在饥饿反应中，内体-内质网（ER）接触位点（EERCS）的动态动员创造了一个受限的环境，促进了Ca2+依赖性吞噬细胞的生物发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.