最优性作为理解发展稳健性的框架。

IF 18.1 1区 生物学 Q1 CELL BIOLOGY
Prachiti Moghe, Edouard Hannezo, Takashi Hiiragi
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引用次数: 0

摘要

胚胎生长、形态发生和模式形成是细胞动力学、命运规范和多尺度物理力之间协调的复杂过程。尽管基因表达、细胞特性和组织生长存在固有的异质性,但了解胚胎发育的稳健性是如何实现的是一个基本问题。尽管基因表达、信号传导、细胞和组织力学之间的各种反馈已被发现赋予发育系统的稳健性,但从定量角度测量变异性和稳健性通常仍然具有挑战性。此外,在许多发育中的组织中缺乏细胞命运可塑性,这是一种能够赋予细胞健壮性的关键机制。这篇综述强调了生物学定量方法的最新技术和概念进展如何帮助克服这些瓶颈,特别关注机械化学反馈,或者选择性地调整控制参数,如何确保发育稳健性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimality as a framework for understanding developmental robustness.

Embryo growth, morphogenesis, and patterning are complex processes that coordinate between cellular dynamics, fate specification, and multiscale physical forces. Understanding how robustness in embryo development is achieved despite inherent heterogeneities in gene expression, cell properties, and tissue growth is a fundamental question. Although various feedback between gene expression, signaling, and cell and tissue mechanics have been uncovered to confer robustness on developmental systems, measuring variability and robustness from a quantitative perspective often remains challenging. Furthermore, cell fate plasticity, a key mechanism that can confer robustness, is lacking in many developing tissues. This review highlights how recent technological and conceptual advances in quantitative approaches to biology help to overcome these bottlenecks, with a particular focus on how mechanochemical feedback, or alternatively, selectively tuned control parameters, ensure developmental robustness.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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