Understanding human embryogenesis by building programmable stem cell-based models.

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-09-02 DOI:10.1016/j.tcb.2025.08.003

Carly Guiltinan, Gerrald A Lodewijk, Sayaka Kozuki, S Ali Shariati

引用次数: 0

Abstract

Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.

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通过建立基于可编程干细胞的模型来理解人类胚胎发生。

基于干细胞的胚胎模型为研究一个难以捉摸的发育时期提供了另一种系统。程序化小鼠胚胎模型最近通过表观基因组编辑激活两个内源性调控元件产生。在这篇论坛文章中，我们讨论了这一成就以及将其转化为人类胚胎发生工程模型的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.