ATRX缺失诱导谱系可塑性和鳞状样表型，促进结直肠癌转移。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-08-01 Epub Date: 2025-07-24 DOI:10.1016/j.tcb.2025.07.003

Yali Chen, Gaili Ji, Peishan Hu, Rong Xiang

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引用次数: 0

摘要

结直肠癌（CRC）的转移是由典型上皮-间质转化（EMT）以外的表型可塑性驱动的，包括非典型谱系，如鳞状样表型。其调控机制和临床意义尚不清楚。在最新一期的《自然》杂志上，Cammareri等人发现ATRX缺失是多谱系可塑性的驱动因素，包括鳞状样特征，与CRC转移增加和临床预后差有关。

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ATRX loss induces lineage plasticity and squamous-like phenotype to promote colorectal cancer metastasis.

Colorectal cancer (CRC) metastasis is driven by phenotypic plasticity beyond classic epithelial-mesenchymal transition (EMT), including non-canonical lineages such as squamous-like phenotypes. Their regulatory mechanisms and clinical significance remain unclear. In the current issue of Nature, Cammareri et al. identified ATRX loss as a driver of multilineage plasticity, including squamous-like characteristics, linked to increased metastasis and poor clinical outcomes in CRC.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.