Journal of Herbal Medicine最新文献

{"title":"Chemical composition and antimicrobial activity of Plinia rivularis essential oil against multidrug-resistant bacteria","authors":"Gabriela Moessa Louro ,&nbsp;Eduardo João Coutinho ,&nbsp;Maiara Viviane Oliveira dos Santos ,&nbsp;Marcia Soares Mattos Vaz ,&nbsp;Marcia Regina Pereira Cabral ,&nbsp;Michele Castro de Paula ,&nbsp;Simone Simionatto ,&nbsp;Cláudia Andrea Lima Cardoso ,&nbsp;Euclésio Simionatto","doi":"10.1016/j.hermed.2024.100949","DOIUrl":"10.1016/j.hermed.2024.100949","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasingly common occurrences of multidrug-resistant bacteria represent a global health threat and the discovery of new alternative remedies is necessary. The use of essential oils (EOs) in the treatment of many pathogenic bacteria is promising and several examples have already been highlighted regarding their inhibitory action. Among the botanical families, Myrtaceae stands out for presenting important species that supply bioactive products.</div></div><div><h3>Methods</h3><div>In this work we investigate the chemical composition of <em>Plinia rivularis</em> (Myrtaceae) leaf EO and its antibacterial activity against resistant and non-resistant bacteria. The EO was obtained by two methods, hydrodistillation and steam distillation. Gas chromatography-flame ionization detector (GC-FID), gas chromatograph-mass spectrometry (GC-MS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FTIR) were the techniques used in the EO chemical characterization.</div></div><div><h3>Results</h3><div>The EOs were obtained with yields of 0.37 and 0.16% by hydrodistillation and steam distillation methods, respectively. The analyzes revealed the EOs chemical profile showing the compounds 2H-benzocyclohepten-2-one,3,4,4a,5,6,7,8,9-octahydro-4a-methyl (synonym: 4a-methyl-3,4,4a,5,6,7,8,9-octahydro-2H-benzo[7]annulen-2-one), rosifoliol, β-eudesmol and the diterpene kaurene as main constituents. Through preparative thin-layer chromatography (PTLC), it was possible to obtain the diterpene kaurene with a content of 91%, which was also characterized by NMR. The minimum inhibitory concentrations of EO against bacteria ranged from 0.56 to 2.25 mg.ml⁻¹ and 2.25–36 mg.ml⁻¹ for sensitive and resistant bacteria, respectively. Also, EO showed synergistic activity with amikacin and cefotaxime against carbapenem-resistant <em>Pseudomonas aeruginosa</em> (KPC).</div></div><div><h3>Conclusions</h3><div>This is the first report on the chemical composition of <em>P. rivularis</em> EO. Comparison of extraction methods showed variation in yields and small changes in component content. The EO demonstrated activity against resistant and non-resistant bacteria. In addition, the synergistic effect of EO against resistant bacteria may be explored in future studies.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100949"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review article on the antimicrobial and antioxidant essential oils of aromatic plants in Ethiopia","authors":"Destaw Damtie","doi":"10.1016/j.hermed.2024.100948","DOIUrl":"10.1016/j.hermed.2024.100948","url":null,"abstract":"<div><h3>Introduction</h3><div>Ethiopia has eight vegetation types across altitudes (&lt; 400 - 4533 m). Consequently, it is biologically rich (&gt; 6500–7000 plant species) with 12–19% endemicity. While medicinal plant knowledge in Ethiopia is partially documented, much remains unexplored. This study reviews the essential oils (EOs) of aromatic plants in Ethiopia, known for their antimicrobial and antioxidant properties.</div></div><div><h3>Methods</h3><div>From November to December 2022, we retrieved 28 studies from PubMed/Medline, Science Direct, SciVerse, Web of Science, and Google Scholar using boolean operators and terms such as ‘essential oil,’ ‘biological activities,’ ‘bioactivy,’ ‘antioxidant activities,’ ‘antibacterial activities,’ ‘antifungal activities,’ ‘antimicrobial activities,’ and ‘Ethiopia.’</div></div><div><h3>Results</h3><div>Promising antibacterial EOs include <em>Mentha aquatica</em>, <em>Apium leptophyllum</em>, <em>Citrus reticulata</em>, <em>Mentha arvensis</em>, <em>Mentha longifolia, Mentha piperita, Mentha spicata, Olea europaea</em>, <em>Otostegia integrifolia, Phytolacca dodecandra</em>, <em>Plectranthus marrubatus</em>, <em>Salvia nilotica</em>, <em>Salvia officinalis</em>, and <em>Salvia schimperi</em> (MICs &lt; 0.005 to 0.064 mg/mL). For antifungal activity, notable EOs include <em>Acokanthera schimperi, Cinnamomum zeylanicum, C. reticulata, C. reticulata, O. europaea, O. integrifolia, P. dodecandra, P. marrubatus, Satureja paradoxa,</em> and <em>Thymus schimperi</em> (MICs &lt; 1 mg/mL). Antioxidant essential oils were those of <em>Artemisia absinthium</em> L., <em>Artemisia abyssinica</em>, <em>Artemisia afra, Coriandrum sativum, Curcuma domestica, Juniperus procera</em>, <em>Lippia adoensis</em>, <em>Ocimum basilicum</em>, <em>O. europaea</em>, <em>Rosmarinus officinalis</em>, <em>S. officinalis</em>, <em>Satureja abyssinica</em>, and <em>S. paradoxa.</em> The IC₅₀ of all these essential oils was &lt; 0.05 mg/mL.</div></div><div><h3>Conclusion</h3><div>The present review identified the EOs of many Ethiopian aromatic plants with promising antimicrobial and antioxidant activities that demand more enquiry for preclinical testing, and eventually, clinical applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100948"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Lippia multiflora in the management of stage I hypertension: outcomes of a randomised controlled trial","authors":"Ama Kyeraa Thomford ,&nbsp;Kwesi Prah Thomford ,&nbsp;Andrews Ebo Tetteh ,&nbsp;Rosemary Sorkpor ,&nbsp;Joseph Yorke","doi":"10.1016/j.hermed.2024.100947","DOIUrl":"10.1016/j.hermed.2024.100947","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertension is a growing public health problem in the developing world. The chronic nature of the disease has been a driver for the use of traditional medicines. Clinical validation of such products for their safety and efficacy is thus of public health importance. We report on the clinical safety and effectiveness of a <em>Lippia multiflora-</em>based herbal antihypertensive <em>(LMT-19)</em>.</div></div><div><h3>Methods</h3><div>A randomised controlled study was conducted among 80 volunteers clinically diagnosed, per the WHO criteria, with stage I hypertension. Participants received either an aqueous infusion of <em>LMT-19</em> plus a standard lifestyle and dietary recommendation based on a Dietary Approaches to Stop Hypertension (DASH) diet or the lifestyle and dietary recommendation alone.</div></div><div><h3>Results</h3><div>The use of <em>LMT-19</em> resulted in a significant decline of blood pressure over a 60-day period. Diastolic blood pressure in the <em>LMT-19</em> group was found to be significantly lower compared to the control (<em>mean diff</em>: 8.25 (±1.50); <em>P</em> ≤ 0.001). Systolic blood pressure was also significantly better compared to the control group (<em>mean diff:</em> 12.70 ± 2.02; <em>P</em> ≤ 0.001). The product was also well tolerated as no adverse drug reactions were also recorded during the study.</div></div><div><h3>Conclusion</h3><div>These outcomes suggest <em>LMT-19</em> as a potential alternative remedy for management of stage I hypertension.</div></div><div><h3>Clinical trial registration</h3><div>Pan-African Clinical Trial Registry, PACTR202107733803271.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100947"},"PeriodicalIF":2.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of compound xueshuantong capsule in reducing cardiovascular diseases and associated ophthalmic complications: a multi-centre retrospective study","authors":"Boshi Liu ,&nbsp;Min Zhu ,&nbsp;Fei Gao ,&nbsp;Shaolin Du ,&nbsp;Minyu Chen ,&nbsp;Shuo Chen ,&nbsp;Richeng Yu ,&nbsp;Long Pang ,&nbsp;Juping Liu ,&nbsp;Xiaorong Li","doi":"10.1016/j.hermed.2024.100943","DOIUrl":"10.1016/j.hermed.2024.100943","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to explore the effectiveness and value of compound xueshuantong capsule (CXC) in the treatment of diseases by evaluating its potential to reduce cardiovascular diseases (CVDs) and ophthalmic complications.</div></div><div><h3>Methods</h3><div>A total of 5<!--> <!-->104 patients with fundus vascular diseases including retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR), hypertensive retinopathy, periphlebitis of retina, age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), and anterior ischaemic optic neuropathy (AION) were enroled across seven hospitals from 2002 to 2022. All participants were randomised categorised into two groups: CXC combination group (CXC alone or combined with hypoglycemic, lipid-lowering, or anti-hypertensive drugs, and other microcirculation and fundus angiopathy medications), and non-CXC group (only taking the above-mentioned medicines).</div></div><div><h3>Results</h3><div>Kaplan-Meier curves illustrated a lower incidence of cardio-cerebrovascular events and ophthalmic complications in CXC group compared with other group at a significant difference observed. Further stratification revealed a decreased risk of ophthalmic complications in CXC group, and supported by multivariate analysis through adjusting for baseline confounding factors.</div></div><div><h3>Discussion/Conclusions</h3><div>Our findings further confirmed the potential value of CXC in treating cardio-cerebrovascular diseases and associated ophthalmic complications, and accompanying with less side effects at the same time.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100943"},"PeriodicalIF":2.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemocompatibility and hemorheological activity of aqueous extracts from Phyllanthus sellowianus: effects on in vitro glycated erythrocytes","authors":"Hermano Mascaro Grosso ,&nbsp;Patricia Buszniez ,&nbsp;Bibiana D. Riquelme","doi":"10.1016/j.hermed.2024.100945","DOIUrl":"10.1016/j.hermed.2024.100945","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Phyllanthus sellowianus</em> (Klotzsch) Müll Arg. is an Argentinian and Brazilian native plant used to treat diabetes. In vascular diseases like diabetes, erythrocytes form anomalous aggregates resistant to dissociation, associated with high glucose levels. This work aims to evaluate the hemocompatibility and hemorheological activity of aqueous extracts from <em>P. sellowianus</em> and its anti-diabetic activity using <em>in vitro</em> glycated erythrocytes as occur by hyperglycemia.</div></div><div><h3>Methods</h3><div>For this work, <em>P. sellowianus</em> specimens were collected on the Nogoyá River coast, Argentina, and morphoanatomical identified. Infusion, maceration, digestion, and cooking extracts were prepared with collected leaves and bark using saline as solvent. The osmolality and pH of the extracts were adjusted to an adequate interaction with human cells. Red blood cells (RBCs) from healthy donors (n=3) were used and incubated with glucose solution for <em>in vitro</em> simulation of the hyperglycemia effects. RBCs were incubated with the aqueous extracts to assess their hemocompatibility. Also, glycated RBCs were incubated with the extracts to analyze their anti-diabetic properties. Erythrocyte Rheometer and Optical Chip Aggregameter were used for the hemorheological evaluation.</div></div><div><h3>Results</h3><div>Assays with the different <em>P. sellowianus</em> extracts modified the viscoelasticity and aggregation of RBCs. Moreover, in some cases, <em>P. sellowianus</em> extracts reversed the <em>in vitro</em> glycation effect and hemorheological parameters got nearer control values.</div></div><div><h3>Conclusion</h3><div>These results would be helpful for the development of pharmaceutical formulations using this species or its phytocomponents. They also give relevant information to understand the action mechanisms through which these extracts or their components can be used as anti-diabetics in Phytomedicine.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100945"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of herbal medicine in relieving complications related to cancer treatments: an evidence-based systematic review","authors":"Hamed Delam ,&nbsp;Zahra Moradi Kouchi ,&nbsp;Hamed Safari","doi":"10.1016/j.hermed.2024.100944","DOIUrl":"10.1016/j.hermed.2024.100944","url":null,"abstract":"<div><h3>Introduction</h3><div>Today, cancer patients suffer from acute or chronic complications related to these treatments due to the use of common cancer treatments, including chemotherapy and radiation therapy. Some people use complementary medicine such as herbal medicine to reduce or eliminate these side effects. Therefore, the current study was designed with the aim of determining the effects of herbal medicines on complications related to cancer treatments in 2023.</div></div><div><h3>Methods</h3><div>This study is an evidence-based systematic review designed in 2023. Studies of randomised controlled trials that were published in four reliable databases PubMed/Medline, Scopus, ISI and Google Scholar were selected for review. Finally, 43 articles were selected for final review and data extraction. The herbal medicines considered for the present study included Senna, ginger, lavender, chamomile, ginseng, mint, Rikkunshito, Aloe vera and ginseng.</div></div><div><h3>Results</h3><div>The results of most of the trials showed the favourable effects of herbal medicines in reducing the complications associated with cancer treatments. Also, no serious side effects were reported after taking this class of drugs. Although a large number of people use complementary treatments, especially medicinal plants, and know it as a safe treatment, but patients and medical staff have little information about the effect of medicinal plants on the symptoms of diseases. This situation can lead to improper use of herbal medicines.</div></div><div><h3>Conclusions</h3><div>In general, the results of the study showed that medicinal plants as a complementary treatment can have a positive effect on the improvement of symptoms and complications related to cancer treatments. Clinicians can suggest the use of medicinal plants along with other standard drugs or even alone to patients and reduce the side effects and costs of patients to a great extent.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100944"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-Blind, Randomised, Placebo-Controlled Study Evaluating the Efficacy of an Early Treatment Using Herbal Supplement in the Prevention of Post-traumatic Stress Disorder in the Emergency Department (PHYTéS Study)","authors":"R. Boukef ,&nbsp;I. Trabelsi ,&nbsp;R. Youssef ,&nbsp;H. Yaakoubi ,&nbsp;A. Sekma ,&nbsp;R. Jaballah ,&nbsp;K.B. Ali ,&nbsp;H. Ben Salah ,&nbsp;S. Mabsout ,&nbsp;F. Boukadida ,&nbsp;Z. Dhifaoui ,&nbsp;F. Graa ,&nbsp;S. Nouira ,&nbsp;L. Boukadida ,&nbsp;A. Zorgati","doi":"10.1016/j.hermed.2024.100946","DOIUrl":"10.1016/j.hermed.2024.100946","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-traumatic stress disorder (PTSD) poses a major challenge to mental health. Current treatments primarily address PTSD symptoms after their onset, and there is a critical need for effective early intervention strategies. While several studies have explored various therapies, including pharmacological and psychotherapeutic approaches, there is a notable gap in research regarding preventive interventions. This study investigates the efficacy of Aleozen®, a herbal supplement, in preventing PTSD among high-risk individuals. Aleozen® contains a blend of plant extracts such as Griffonia simplicifolia, Rhodiola rosea, Gentiana lutea, Crataegus oxyacantha, Eschscholtzia californica, and Melissa officinalis, which have shown promise in mitigating stress and anxiety.</div></div><div><h3>Methods</h3><div>In a randomized controlled trial, high-risk participants who experienced recent trauma were administered Aleozen® or a placebo over a 12-week period. Participants were assessed using standardized PTSD symptom scales and physiological markers of stress at baseline, mid-point, and end of the study. The primary outcome was the reduction in PTSD symptoms compared to the placebo group.</div></div><div><h3>Results</h3><div>Participants receiving Aleozen® exhibited a statistically significant reduction in PTSD symptom severity compared to the placebo group. The mean reduction in PTSD symptom scores was 35% in the Aleozen® group versus 12% in the placebo group (p &lt; 0.01). Additionally, Aleozen® was associated with improvements in secondary outcomes, including reduced anxiety and better sleep quality. There were no significant adverse effects reported, suggesting that Aleozen® is both effective and well-tolerated.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that Aleozen® significantly reduces PTSD symptoms and related distress in high-risk individuals when administered early after trauma.</div></div><div><h3>Clinical registration Number</h3><div>It was recorded in the ClinicalTrials.gov register (NCT03724448) on June 26, 2018.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100946"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity and molecular docking analysis of Salsola kali: investigating potent biological interactions and chemical composition","authors":"Erdi Can Aytar ,&nbsp;Betül Aydın ,&nbsp;Emine Incilay Torunoğlu ,&nbsp;Alper Durmaz","doi":"10.1016/j.hermed.2024.100942","DOIUrl":"10.1016/j.hermed.2024.100942","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the antioxidant, phenolic, and antimicrobial properties of Salsola kali and examines the molecular binding interactions of its biologically active compounds with various proteins.</div></div><div><h3>Methods</h3><div>Ethanol extract from the aerial parts of <em>Salsola kali</em> was analyzed for DPPH free radical scavenging activity, iron chelating activity, total phenolic content, and total flavonoid content. Antimicrobial activity was tested against several bacterial strains, and the active components of the extract were identified through chemical analysis. Molecular docking studies assessed the binding interactions of these compounds with different protein targets.</div></div><div><h3>Results</h3><div>The ethanol extract exhibited strong antioxidant activity, with a DPPH IC₅₀ value of 0.12 ± 0.02 μg/mL and an iron chelating IC₅₀ value of 3.96 ± 0.19 mg/ml. The total phenolic content was measured at 153.61 ± 5.41 mg GAE/g extract, while the total flavonoid content was 303.25 ± 12.68 mg QE/g extract. Significant antimicrobial activity was observed against <em>E. coli</em> (MIC = 25 μg/ml) and <em>S. aureus</em> (MIC = 6.25 μg/ml). The analysis identified 15 biologically active compounds, with 2-methoxy-1,3-dioxolane and Nonane, 3-methyl-5-propyl as the most abundant. Molecular docking studies revealed strong binding affinities with various proteins, with binding energies ranging from -4.9 to -6.7 kcal/mol.</div></div><div><h3>Conclusion</h3><div>The phenolic and flavonoid content of <em>S. kali</em> indicates significant antioxidant and antimicrobial activities. The identified compounds show promising binding interactions with proteins, suggesting potential pharmacological applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100942"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential cytotoxic effects of Garcinia mangostana pericarp extract on leukaemic versus normal human cell lines: insights into selective anticancer activity","authors":"Sabrina D. Zeppa ,&nbsp;Matteo Micucci ,&nbsp;Fabio Ferrini ,&nbsp;Anna M. Gioacchini ,&nbsp;Giovanni Piccoli ,&nbsp;Lucia Potenza ,&nbsp;Alessia Bartolacci ,&nbsp;Giosuè Annibalini ,&nbsp;Asher A. Rehman ,&nbsp;Cinzia Calcabrini ,&nbsp;Vilberto Stocchi ,&nbsp;Piero Sestili","doi":"10.1016/j.hermed.2024.100937","DOIUrl":"10.1016/j.hermed.2024.100937","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Garcinia mangostana L.</em> is widely recognised for its traditional medicinal uses and growing relevance in the nutraceutical sector. This research endeavour is designed to scrutinise the phytochemical composition and cytotoxic effects of an alcoholic extract derived from the pericarps of <em>G. mangostana</em> (ME) on leukaemic cell lines.</div></div><div><h3>Methods</h3><div><em>G. mangostana</em> L. pericarps were subjected to ethanol extraction, and subsequent compound identification was conducted via Capillary Liquid Chromatography-Electrospray Ionisation-Quadrupole Time-of-Flight Tandem Mass Spectrometry (CapLC-ESI-QTOF-MS/MS). In parallel, the extract was fractionated through High-Performance Liquid Chromatography (HPLC). Furthermore, U937, Jurkat and normal human umbilical vein endothelial cell (HUVEC) lines were exposed to varying concentrations of the extract to assess cell proliferation, viability, cytotoxicity, and apoptotic DNA damage.</div></div><div><h3>Results</h3><div>Investigations confirmed the presence of various xanthones, including β-mangostin, α-mangostin, and garcinone E. Significantly, ME displayed pronounced cytotoxic effects specifically on leukaemic cells, distinguishing its impact on malignant cells as opposed to non-malignant ones, and facilitated apoptotic DNA fragmentation. Moreover, the whole extract consistently displayed greater cytotoxicity compared to individual fractions.</div></div><div><h3>Conclusion</h3><div>According to the results obtained ME selective cytotoxicity against cancer cell lines and greater biological activity than the single compounds in the extract. These findings underscore ME's potential in cancer prevention, complementing dietary strategies ahead of pharmaceutical interventions.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100937"},"PeriodicalIF":2.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidics assisted green synthesis of copper oxide nanoparticles from the aqueous leaf extract of Ipomoea quamoclit L. with its antimicrobial and antioxidant activity","authors":"D. Joanna Magdalene,&nbsp;D. Muthuselvam","doi":"10.1016/j.hermed.2024.100940","DOIUrl":"10.1016/j.hermed.2024.100940","url":null,"abstract":"<div><h3>Introduction</h3><div>Green nanosynthesis of medicinal plants are useful for the development of antibiotic agents. In this work, we have explored the antimicrobial and antioxidant activity of green synthesised copper oxide (CuO) nanoparticles (NPs) from tropical medicinal plant <em>Ipomoea quamoclit</em> L.</div></div><div><h3>Methods</h3><div>With the aid of microfluidic technology, a low-cost, polydimethylsiloxane (PDMS) lab-on-chip micromixer for green nanosynthesis of CuO nanoparticle using <em>Ipomoea quamoclit</em> is presented. The UV–Vis characteristics, Fourier Transform Infra-red (FTIR) spectrum, antimicrobial and antioxidant response using DPPH and hydrogen peroxide (H₂O₂) were reported. The antimicrobial efficacy of the synthesised CuO-NPs is tested against two-gram positive bacteria <em>Staphylococcus aureus, Micrococcus luteus,</em> two gram negative bacteria, <em>Enterobacter cloacae</em>, <em>Klebsiella pneumoniae</em> and two fungi species <em>Candida albicans</em>, <em>Aspergillus niger.</em></div></div><div><h3>Results</h3><div>UV–Vis spectrum for the synthesised CuO-NPs showed the absorbance at 670 nm, scanning electron microscope (SEM) image analysis and dynamic light scattering (DLS) analysis confirmed the presence of spherical shaped nanoparticle sized between 65 and 94.5 nm. The presence of bioactive functional groups of N-H, C-H and C=0 stretching was identified using Fourier Transform Infrared spectroscopy (FTIR). The maximum mean zone of inhibition obtained was 10.45<!--> <!-->±<!--> <!-->0.25 mm for fungi <em>A. niger</em>. The antioxidant activity using DPPH scavenging assay and hydrogen peroxide scavenging assay showed the IC₅₀ value 33.94 μg/ml and 42.54 μg/ml respectively.</div></div><div><h3>Conclusions</h3><div>The obtained results reveal the potential of CuO-NPs synthesised from <em>I. quamoclit</em> L. as a remarkable medicinal entity for wound healing, respiratory infection, fungal infection and urinary tract infection along with the improved antimicrobial and antioxidant activity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100940"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}