Journal of Herbal Medicine最新文献

{"title":"Ethnobotanical study of plants used in treating skin ailments and dermato-cosmetics among population of Sidi Kacem, Northeast of Morocco","authors":"Mostafa El Khomsi ,&nbsp;Anouar Hmamou ,&nbsp;Nor El houda Tahiri ,&nbsp;Najoua Soulo ,&nbsp;Meryem Doubi ,&nbsp;Driss Hmouni","doi":"10.1016/j.hermed.2025.101045","DOIUrl":"10.1016/j.hermed.2025.101045","url":null,"abstract":"<div><h3>Introduction</h3><div>To address the threat of the disappearance of oral knowledge of traditional medicinal and cosmetic plants, an ethnobotanical study of plants used in treating skin diseases and dermato-cosmetics was carried out in the Sidi Kacem region.</div></div><div><h3>Methods</h3><div>A total of 530 local residents took part in the study. The method adopted was based on semi-structured interviews with open-ended questions. The data collected were analysed using basic statistical tools and quantitative indices such as use value of botanical family (FUV), species use value (SUV), Fidelity level (FL), informant agreement ratio (IAR) and part of the plant value (PPV).</div></div><div><h3>Results</h3><div>A total of 84 plant species in 41 botanical families were recorded, with a marked predominance of the Lamiaceae family, represented by 11 species (FUV = 0,18). Among these plants, <em>Rosmarinus officinalis</em> L. has the highest use value (SUV = 0,63). In terms of conditions treated, cosmetic uses and viral infections have the highest index of informant agreement ratio (IAR = 0,97). The maximum fidelity level reached 100, indicating a high degree of consistency in plant use. Leaves are the most frequently used part (PPV = 0,478), while powder form is the most common method of preparing remedies.</div></div><div><h3>Discussion/Conclusion</h3><div>The survey highlighted the diversity of plant species and the strength of traditional knowledge associated with medicinal and cosmetic plants. Based on these results, the researchers encourage the scientific community to further investigate the phytochemical and pharmacological properties of local medicinal plants.</div></div><div><h3>Data and model availability statement</h3><div>The datasets used and/or analyzed during the current study are available in the manuscript.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"53 ","pages":"Article 101045"},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural comparison of antidiabetic medicinal plants used in Algeria and Morocco","authors":"Sarra Maamri ,&nbsp;Mourad Djeziri ,&nbsp;Souhila Mendil ,&nbsp;Lydia Terfi","doi":"10.1016/j.hermed.2025.101043","DOIUrl":"10.1016/j.hermed.2025.101043","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetes is a chronic endocrine disease of global concern. The aim of this study is to provide a comparative analysis of ethnomedical practice used for diabetes management in Algeria and Morocco, offering a scientific basis for the development of alternative therapies and innovative drug discovery.</div></div><div><h3>Methods</h3><div>Ethnomedical information was normalised from quantitative ethnobotanical studies. Principal component analysis (PCA) was used to compare regional data, complemented by hierarchical ascending classification (HAC) to identify similarity in plant use, plant parts, and preparation methods.</div></div><div><h3>Results</h3><div>A total of 225 species (68 families) in Algeria and 222 species (64 families) in Morocco were identified, with 95 species common to both countries (around 30%). PCA revealed interregional variabilities of 42.60% (Algeria) and 43.43% (Morocco). HAC subdivided the heterogeneous dataset into homogeneous groups based on plant usage, plant parts, and preparation modes. These groupings reflect both a shared ethnomedicinal heritage and region-specific adaptations, highlighting the balance between redundancy and divergence within the phytotherapeutic practice, which underpins its stability and therapeutic diversity.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that ethnobotanical knowledge is a dynamic and valuable resource, transcending cultural boundaries and providing a robust foundation for the discovery of novel antidiabetic formulations. The nuanced balance between common frameworks and unique phytotherapeutic specificities supports the development of complementary or synergistic therapies.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"53 ","pages":"Article 101043"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacological survey of medicinal plants used in the treatment of female infertility in two localities of Melong subdivision-Cameroon","authors":"Rose Winny Ebong Eyango ,&nbsp;Landry Lienou Lienou ,&nbsp;Marie Stephanie Chekem Goka ,&nbsp;Richard Tagne Simo ,&nbsp;Fabrice Fabien Dongmo Dongho ,&nbsp;Leonce Martin Tchiffo Noubosse ,&nbsp;Rosalie Anne Ngono Ngane ,&nbsp;Bruno Phélix Telefo","doi":"10.1016/j.hermed.2025.101042","DOIUrl":"10.1016/j.hermed.2025.101042","url":null,"abstract":"<div><h3>Introduction</h3><div>The scarcity of conventional infertility treatments and the erosion of traditional medicinal knowledge pose significant challenges. This study aims to document and preserve herbal remedies of Moungo’s division against female infertility, leveraging the rich heritage of ancestral healing practices.</div></div><div><h3>Methods</h3><div>An ethnopharmacological survey was conducted on twenty traditional healers in Mbouroukou and Mouanguel, localities of the Melong sub-division (Littoral-Cameroon). A structured questionnaire collected data on plant-based treatments, supplemented by a comprehensive literature review on the botanical and therapeutic properties of these plants.</div></div><div><h3>Results</h3><div>The survey identified 50 plant species belonging to 35 families, utilised in 31 recipes. The majority of these recipes (19) combined multiple plants, while 12 were single-plant preparations. The Leaf was the most commonly used plant part (37.15%), with decoction being the primary preparation method (55.20%). Water was the mostly used solvent (75.85%) and treatments were predominantly administered via the anal route (54.84%), with dosages ranging from one to twelve purge bulbs per day over various treatment durations. Notably, <em>Solanum aculeastrum, Musa parasidiaca, Ageratum conyzoides,</em> and <em>Commelina benghalensis</em> were the plants most frequently mentioned by the interviewees.</div></div><div><h3>Conclusion</h3><div>The study reveals a rich diversity of therapeutic knowledge among traditional healers in Melong subdivision for treating female infertility. Acknowledging and integrating this ethnobotanical knowledge is essential for the conservation of medicinal plant species and the optimisation of therapeutic interventions aimed at improving women's reproductive health outcomes.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"53 ","pages":"Article 101042"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Anti-inflammatory Potential of Mitragyna parvifolia: A Mechanistic and Data-Driven Approach to Herbal Medicine","authors":"Sukanya Pote ,&nbsp;Preeti Salve ,&nbsp;Sachin Gudasi ,&nbsp;Shailendra Gurav","doi":"10.1016/j.hermed.2025.101038","DOIUrl":"10.1016/j.hermed.2025.101038","url":null,"abstract":"<div><h3>Introduction</h3><div>Inflammation is a protective physiological response, but its chronic manifestation leads to adverse health outcomes. Current anti-inflammatory treatments often have significant side effects, necessitating safer alternatives. <em>Mitragyna parvifolia</em>, a medicinal plant, has demonstrated anti-inflammatory potential, though its mechanisms remain underexplored. The current study was designed to explore the anti-inflammatory mechanisms of <em>M parvifolia</em>, emphasising its potential as therapeutic agent for inflammatory diseases.</div></div><div><h3>Methods</h3><div>This study employed <em>in silico</em> approaches, including network pharmacology, molecular docking, and molecular dynamic simulations, to identify interactions between <em>M parvifolia</em> phytocompounds and inflammatory targets. Experimental validation was conducted using supercritical CO₂ leaf extract, evaluated for cytotoxicity, protein denaturation, COX-2 inhibition, and HRBC membrane stabilisation and phytochemical profiling using LC-QTOF-MS analysis.</div></div><div><h3>Results</h3><div>Thirteen phytocompounds of <em>M parvifolia</em> were found to modulate 97 inflammatory targets, significantly impacting Interleukin-17 and TNF signalling pathways. Molecular docking revealed strong binding of compounds to key targets, including MMP9 and PTGS2, with the MMP9-Corynan-17-ol complex showing the highest stability in simulations. LC-QTOF-MS analysis identified 10 major bioactive constituents, supporting <em>in silico</em> predictions. Experimental assays confirmed low cytotoxicity (&gt;90% cell viability) and demonstrated potent anti-inflammatory effects: 73.71% ± 1.5% inhibition of COX-2 activity, 73.9% ± 0.4% inhibition of protein denaturation, and 75.5% ± 0.83% HRBC membrane stabilisation at maximum concentrations.</div></div><div><h3>Conclusions</h3><div><em>M parvifolia</em> exhibits significant anti-inflammatory properties through modulation of key pathways and targets, combined with strong experimental validation of its efficacy and safety. These findings position <em>M parvifolia</em> as a promising candidate for developing natural, safer anti-inflammatory therapies.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101038"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Silver Nanoparticles Using Mangifera indica Leaves and Their Antibacterial Efficacy Against Multidrug-Resistant Bacteria","authors":"Mohammed Alissa","doi":"10.1016/j.hermed.2025.101039","DOIUrl":"10.1016/j.hermed.2025.101039","url":null,"abstract":"<div><div>The rise of multidrug-resistant bacteria presents a critical challenge to healthcare, prompting the need for alternative antimicrobial strategies. This study explores the potential of <em>Mangifera indica</em> (mango leaves) combined with silver nanoparticles (<strong>AgNPs</strong>) as a solution due to their bioactive properties. Phytochemical screening confirmed the presence of key bioactive compounds, including terpenoids, steroids, phenols, flavonoids, tannins, and biomolecules such as magniferin and benzoquinone di-tert-butyl derivative. Silver nanoparticles were synthesised using both aqueous and ethanolic extracts, with the antibacterial efficacy tested against methicillin-resistant <em>Escherichia coli</em>, oxacillin-resistant <em>Klebsiella spp</em>, methicillin-resistant <em>Pseudomonas aeruginosa</em>, and methicillin-resistant <em>Staphylococcus aureus</em>. The ethanolic extract demonstrated superior antibacterial activity, with inhibition zones of 19.7 mm against <em>E coli</em>, 26.8 mm against <em>Klebsiella spp</em>, 22.9 mm against <em>P aeruginosa</em>, and 24.1 mm against <em>S aureus</em> at 100 mg/ml. The ethanolic extract also exhibited lower minimum inhibitory concentration and minimum bactericidal concentration values, indicating greater potency compared to the aqueous extract. These results align with previous research, where plant-derived AgNPs, particularly from ethanolic extracts, have shown stronger antimicrobial activity due to better solubility of bioactive compounds. Overall, <em>M indica</em> extracts synthesised with AgNPs, especially using ethanol, offer significant potential in combating multidrug-resistant bacteria and provide an eco-friendly alternative to traditional antibiotics. Further research into clinical applications is recommended.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101039"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guava (Psidium guajava) leverages platelets in dengue haemorrhagic fever in Indonesia: Bayesian and Frequentist ANCOVA recovered meta-analyses","authors":"Jonathan,&nbsp;Theodorus Samuel Rahardja,&nbsp;Dede Fatmawati,&nbsp;Maudy Rahmi,&nbsp;Indah Ridhoila","doi":"10.1016/j.hermed.2025.101037","DOIUrl":"10.1016/j.hermed.2025.101037","url":null,"abstract":"<div><h3>Background</h3><div>Tropical countries with humid climates and large populations, such as Indonesia, have a high prevalence of dengue haemorrhagic fever (DHF). The symptoms can range from mild fever to shock or even death. Spontaneous bleeding due to thrombocytopenia is one such example. Therefore, restoring thrombocyte levels is a key factor in DHF recovery. Contradictory evidence exists regarding the effects of guava (<em>Psidium guajava</em>) on thrombocytes in patients with DHF. In this study, we resolved this debate using Frequentist and Bayesian meta-analyses.</div></div><div><h3>Methods</h3><div>A comprehensive systematic review and meta-analysis of 972 articles from six databases, one registry, and a citation search from conception to 2024 identified seven studies after rigorous inclusion-exclusion filtration. All studies passed the quality assessment using the Risk of Bias 2 tool, Newcastle Ottawa Scale, and the risk of bias in non-randomised studies of interventions. Statistical analysis was performed using R version 4.4.2, analysis of covariance recovered effect size, Bayesmeta, and Metafor packages. Additionally, the authors used a DOI plot and the Luis Furuya-Kanamori index to assess publication bias.</div></div><div><h3>Results</h3><div>The current meta-analysis included seven studies with 234 subjects for the pre- and post-difference in platelet count with a control group contrast. Guava adequately increased the platelet count in DHF patients (63.21 [57.20–69.26] x 10³) in both adult and paediatric patients.</div></div><div><h3>Conclusion</h3><div>We summarise the role of guava in enhancing platelet counts in Indonesia. Guava fruit should be considered a complementary treatment alongside standard medicine for treating adult Indonesian patients with DHF in healthcare facilities and homes.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101037"},"PeriodicalIF":1.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential oil of Cleome coluteoides (Boiss.): phytochemical constituents, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, enzymatic inhibition, and xanthine oxidase inhibitory properties","authors":"Majid Sharifi-Rad ,&nbsp;Jibanjyoti Panda ,&nbsp;Yugal Kishore Mohanta ,&nbsp;Pawel Pohl ,&nbsp;Gokhan Zengin ,&nbsp;Mark G. Moloney","doi":"10.1016/j.hermed.2025.101036","DOIUrl":"10.1016/j.hermed.2025.101036","url":null,"abstract":"<div><h3>Introduction</h3><div>Plant based natural products are well known for their therapeutic potential as they are used to treat many diseases, but these plants need to be validated through the scientific study. Therefore, the present investigation was carried out to evaluate the usefulness of the bioactive compounds present in the essential oils of the <em>Cleome coluteoides.</em></div></div><div><h3>Methods</h3><div>Different parts of the plant, including leaves, flowers, fruits, stems and roots, were used to extract the essential oils. The chemical composition of essential oils was analysed by gas-chromatography mass spectrometry (GC-MS). Their antimicrobial properties were evaluated against several human pathogens (three fungi and four bacteria). The enzyme inhibition activity (α-amylase, tyrosinase, butyrylcholinesterase, acetylcholinesterase inhibitory tests) of the essential oils was evaluated, along with, their antioxidant activity (DPPH, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) tests), xanthine oxidase inhibitory activity, antiproliferative activity (against MCF-7 and Hep-G2), anti-arthritic activity (protein denature assay), and anti-inflammatory activity.</div></div><div><h3>Results</h3><div>Phytol, sclareol, 7-α-hydroxy manool, and piperitone were found to be the main compounds of the studied essential oils. Notable antibacterial, antifungal, enzyme inhibition, antioxidant, xanthine oxidase inhibitory, antiproliferative, anti-arthritic, and inflammatory activities were found form the essential oils. The best activity was found in the case of the essential oils made from leaves.</div></div><div><h3>Discussion<em>/</em>Conclusions</h3><div>These potential biological activities along with the chemical constitutes present in the essential oils of <em>C. coluteoides</em> can make them potentially utilisable in different biomedical and therapeutic applications in the future. Additionally, the studied plant and their essential oils can serve as a natural remedy for a variety of lifestyle diseases.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101036"},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting NAFLD and NASH with Tinospora crispa: insights from network pharmacology and molecular dynamics","authors":"Shuvam Sar ,&nbsp;Nurul Hassan Mondal ,&nbsp;Tanmoy Banerjee ,&nbsp;Amit Kumar Halder ,&nbsp;Nilanjan Ghosh","doi":"10.1016/j.hermed.2025.101035","DOIUrl":"10.1016/j.hermed.2025.101035","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Tinospora crispa</em> (TC), also known as ‘Petawali,’ is an Indian medicinal plant renowned in folk medicine and Ayurveda for its extensive therapeutic properties. Despite its known benefits, the hepatoprotective potential of TC, particularly against Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), remains unexplored scientifically. This study aims to identify phytocompounds in TC that may be effective against NAFLD/NASH-related targets and elucidate their mechanisms of action.</div></div><div><h3>Method</h3><div>We utilised fingerprint-based similarity search analyses to predict targets for each phytocompound. Network pharmacology, facilitated by ‘Cytoscape’ and its ‘Cytohubba’ plugins, was employed to establish connections between specific phytocompounds of TC and potential targets of NAFLD. Molecular docking followed by MM/GB(PB)SA scoring analyses were performed with these phytochemicals against a range of crystal structures and homology models of biological target proteins. Around 500 ns molecular dynamics simulations were conducted for the selected biological targets and docked phytoconstituents to understand dynamic behaviours of the complexes.</div></div><div><h3>Result</h3><div>Molecular docking and MM/GB(PB)SA scoring revealed that 3′-O-methylluteolin, diosmetin, genkwanin, and luteolin may show promising activity whereas molecular dynamics simulation highlighted that 3′-O-methylluteolin might be the most suitable phytochemical for NAFLD treatment.</div></div><div><h3>Conclusion</h3><div>Overall, these four compounds may modulate key proteins such as CYP3A4, MMP1, PPARδ, PPARγ, AKT1, CYP1A2, and STAT3. This study provides a scientific basis for the potential use of TC in managing NAFLD and NASH, encouraging further research and development in this domain.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101035"},"PeriodicalIF":2.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the clinical efficacy of triple therapy and the addition use of TCM in treating Helicobacter pylori-associated gastritis","authors":"Mengli Xiao ,&nbsp;Liying Zhang ,&nbsp;Beihua Zhang ,&nbsp;Liqun Bian ,&nbsp;Zhenhua Li ,&nbsp;Junxiang Li ,&nbsp;Wei Wei ,&nbsp;Min Liu ,&nbsp;Li Liu ,&nbsp;Chuijie Wang ,&nbsp;Shaohong Shi ,&nbsp;Jinkang Xu ,&nbsp;Sheng Xie ,&nbsp;Hong Shen ,&nbsp;Qiang Yang ,&nbsp;Guangjun Yan ,&nbsp;Mingqi Wen ,&nbsp;Fang Lu ,&nbsp;Xudong Tang","doi":"10.1016/j.hermed.2025.101034","DOIUrl":"10.1016/j.hermed.2025.101034","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese Medicine (TCM) has been found to be effective in the treatment of Helicobacter pylori (<em>H. pylori</em>). However, the quality of evidence is limited and there are few studies on TCM of <em>H. pylor</em>i. This trials aimed to examine whether additional use of TCM can lead to better efficacy in the eradication rate of <em>H. pylori</em>.</div></div><div><h3>Methods</h3><div>This study consisted of a multicenter randomized controlled trial and a nonrandomized cohort. Subjects from TCM hospitals were allocated to a treatment group that received triple therapy or a combination group that received triple therapy combined with 2 weeks of herbal bulk or 2 weeks of herbal soup or 4 weeks of herbal soup. Patients in western hospitals received triple therapy (non-randomized control group). The eradication rate of <em>H. pylori</em>, the recurrence rate, the TCM symptom score, the patient-reported outcome scale (PRO), and safety indicators were observed and compared.</div></div><div><h3>Results</h3><div>960 patients screened, 768 were randomly assigned to the randomized treatment group, and 192 were assigned to the non-randomized group. No difference in the <em>H. pylori</em> eradication rate between the combination group compared with triple therapy (<em>P &gt;</em> 0.05). Significant improvements were observed in TCM symptom scores, the quality of life in the combination group (<em>P</em> &lt; 0.05). Moreover, it had a lower incidence of adverse reactions and rates of <em>H. pylori</em> recurrence (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The additional use of TCM in triple therapy improves the quality of life, reduces adverse effects, and recurrence rates.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101034"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring antiepileptic phytochemicals of Ferula assafoetida and underlying molecular mechanism using a combined approach of network pharmacology and molecular docking","authors":"Naman Kapoor ,&nbsp;Harsh Kashyap ,&nbsp;Deepak Ganjewala ,&nbsp;Hina Bansal","doi":"10.1016/j.hermed.2025.101033","DOIUrl":"10.1016/j.hermed.2025.101033","url":null,"abstract":"<div><h3>Introduction</h3><div>Epilepsy is a prevalent and devastating neurological disorder that affects 1–2% of the global population particularly in low- and middle-income countries. There is a growing interest in exploring plant-based alternative therapies for epilepsy as none of the available anti-epileptic drugs provide complete prevention. This study aimed to investigate the bioactive compounds from <em>Ferula assafoetida</em> using computational approach to assess their potential antiepileptic activity and elucidate the mechanisms involved.</div></div><div><h3>Methods</h3><div>First, phytochemical data was extracted from IMPPAT database and mapped with PubChem. Then obtained their absorption and distribution patterns using SwissADME. Therapeutic targets associated with epilepsy were recognised using Swiss Target Prediction and GeneCards database. The target-network was constructed and performed topological, gene ontology and pathway enrichment analysis. Finally, molecular docking was performed.</div></div><div><h3>Results</h3><div>Three key bioactive constituents ferocolicin, luteolin, and farnesiferol with potential anti-epileptic activities were identified. These compounds influenced epileptogenesis by targeting proteins GABRA1, GABRA5, GRIN2B, MTOR, PTPRB, and CHRNA4. Molecular docking revealed stable binding of key constituents with three target proteins related to epileptogenesis. The order of binding affinities of the top three compounds to their respective targets was ferocolicin &gt; farnesiferol &gt; luteolin. This suggested a potentially higher therapeutic efficacy and target specificity of these compounds as compared to standard, valproic acid.</div></div><div><h3>Conclusion</h3><div><em>F. assafoetida</em> could be utilised in the treatment of epilepsy by modulating epileptogenesis pathways. The study endorsed the importance of the efficacy of multicomponent, multi-target compound therapies decoding new therapeutic targets for epilepsy and related conditions.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101033"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}