Journal of Herbal Medicine最新文献

{"title":"The prevalence of gingival recession among miswak (Salvadora persica L.) chewing stick users: a systematic review","authors":"Nadia Suleman ,&nbsp;Miriam Sidrak ,&nbsp;Julie Noussair ,&nbsp;Ana-Maria Stevans ,&nbsp;Bishoy Bakhoum ,&nbsp;Rodrigo Rodrigues Amaral ,&nbsp;João Martins de Mello-Neto","doi":"10.1016/j.hermed.2025.101003","DOIUrl":"10.1016/j.hermed.2025.101003","url":null,"abstract":"<div><h3>Background</h3><div>Miswak, a natural chewing stick from <em>Salvadora persica L., is traditionally used for oral hygiene in Africa, Asia, and the Middle East. Despite evidence of its effectiveness in plaque reduction and periodontal health improvement, its relationship with gingival recession remains understudied.</em></div></div><div><h3>Aim of the study</h3><div>This systematic review evaluates existing literature to determine whether miswak use is associated with gingival recession compared to conventional toothbrush use.</div></div><div><h3>Materials and methods</h3><div>Literature was retrieved from Web of Science, Scopus, PubMed, Ovid MEDLINE, Ovid Emcare, CINAHL, and LILACS to analyse studies evaluating gingival recession prevalence among miswak users from 1983 to 2024. The Joanna Briggs Institute Critical Appraisal tool was used for quality assessment.</div></div><div><h3>Results</h3><div>Analysis of studies including 6<!--> <!-->315 individuals showed varying results. Seven studies reported higher gingival recession prevalence (9.88–67.85%) among miswak users compared to conventional toothbrush users, while two studies reported no recession. Additional findings included increased anterior tooth wear, clinical attachment loss, and tooth loss. Usage frequency, technique, fibre texture, and user age influenced outcomes.</div></div><div><h3>Conclusion</h3><div>The lack of standardised miswak usage techniques contributed to variable outcomes across studies. Some studies suggest increased tooth wear, gingival recession, and abrasion with miswak use, while others report no difference or positive effects on oral health. Miswak's overall impact on periodontal health remains inconclusive, requiring standardised methods and controlled studies to better understand miswak's long-term effects and develop evidence-based usage recommendations.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101003"},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of different traditional Chinese medicine treatment for Corona Virus Disease 2019: systematic review and meta-analysis","authors":"Su Youzhu,&nbsp;Su Rui,&nbsp;Wang Shuo,&nbsp;Liu Mifeng,&nbsp;Fan Jie,&nbsp;Liu Qingquan","doi":"10.1016/j.hermed.2025.101001","DOIUrl":"10.1016/j.hermed.2025.101001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of different treatment methods currently used for COVID-19 infection, providing evidence-based support for treatment decision-making.</div></div><div><h3>Methods</h3><div>Effective drugs for COVID-19 were selected through literature research. Based on the pharmacological effects of the drugs, they were categorised into three treatment methods: Dispersing lung qi and detoxification; Dispersing lung qi, detoxification and eliminating dampness; Dispersing lung qi, detoxification, eliminating dampness and activating qi. Meta-analysis was conducted to evaluate the efficacy of these three treatment methods, clarifying the advantages of different treatment methods.</div></div><div><h3>Results</h3><div>All three treatment methods showed advantages in various aspects such as shortening fever duration, time to nucleic acid conversion, reducing the rate of severe cases, increasing the recovery rate of chest CT scans, and disappearance rate of cough. Dispersing lung qi and detoxification method showed significant advantages in shortening sore throat duration (<em>P</em> &lt; 0.01), while the other two methods showed significant advantages in improving the disappearance rate of chest tightness, shortening the duration of fatigue, and cough duration.</div></div><div><h3>Conclusion</h3><div>All three treatment methods have shown significant efficacy, providing evidence for the comprehensive treatment of epidemic diseases in traditional Chinese medicine. Dispersing lung qi and detoxification method is suitable for patients with obvious heat symptoms, while Dispersing lung qi, detoxification and eliminating dampness and Dispersing lung qi, detoxification, eliminating dampness and activating qi method can regulate the spleen to remove dampness, dredge and regulate the three jiao qi mechanism, fitting the core pathogenesis of COVID-19 involves dampness, toxin, stagnation and closure.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101001"},"PeriodicalIF":2.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers in rheumatoid arthritis patients and effect of Unani herbal formulation Qurs-e-Hudar on these biomarkers suggesting the anti-IL-6 effect","authors":"Towseef Amin Rafeeqi ,&nbsp;Riyaz Ahmed Pandith ,&nbsp;Humma ,&nbsp;Arjumand Shah ,&nbsp;Mohammad Zakir ,&nbsp;Nighat Anjum ,&nbsp;Irfat Ara ,&nbsp;N. Zaheer Ahmed","doi":"10.1016/j.hermed.2025.100999","DOIUrl":"10.1016/j.hermed.2025.100999","url":null,"abstract":"<div><h3>Introduction</h3><div>One of the herbal formulations known as Qurs-e-Hudar used in the Unani medicine for the treatment of rheumatoid arthritis (RA), has no known mechanism of action. In this endeavour, the effect of Qurs-e-Hudar on serum biomarkers in RA patients was evaluated.</div></div><div><h3>Methods</h3><div>In an open-label, single-centric clinical study, 26 RA patients were assessed for 6-week treatment by Qurs-e-Hudar in a dose of 250 mg twice a day. The serum was evaluated quantitatively for biomarkers including rheumatoid factor (RF), anti–cyclic citrullinated peptide (anti-CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM1), interleukin 6 (IL-6), and chemokine ligand 13 (CXCL13) before and after treatment in RA patients and 26 healthy participants at once.</div></div><div><h3>Results</h3><div>The ESR, CRP, TNFR1, IL-6 and CXCL13 values were significantly high (<em>P</em> &lt; 0.05) in RA patients comparing healthy controls. There was a significant reduction in (<em>P</em> &lt; 0.05) in ESR and IL-6 values after treatment in RA patients. Although non-significant, a reduction in TNFR1 and CXCL13 was also observed. The results for efficacy assessed by reduction in disease activity score-28 (DAS-28) and remission assessed by the ACR-EULAR classification show a significant decrease (P &lt; 0.01) after treatment in RA patients.</div></div><div><h3>Conclusion</h3><div>The significant clinical efficacy response obtained here is likely to be related to a significant reduction of IL-6 and ESR suggesting the role of Qurs-e-Hudar through IL-6 pathway. Larger systematic and comparative trials are warranted for further evaluation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100999"},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticariogenic efficacy of Indian Costus mouthwash in children","authors":"Ghada Salem ,&nbsp;Maryam ElMansy ,&nbsp;Eman Allam ,&nbsp;Asem Anter ,&nbsp;Rehab Abdelmonem ,&nbsp;Mohamed Rashed","doi":"10.1016/j.hermed.2025.100997","DOIUrl":"10.1016/j.hermed.2025.100997","url":null,"abstract":"<div><h3>Introduction</h3><div>Herbal mouthwashes have become more popular in recent years as a countermeasure to the side effects of conventional mouthwashes. The aim of this study was to investigate the anti-bacterial effect of different concentrations of newly formulated Indian Costus mouthwash against <em>Streptococcus mutans</em> bacteria (<em>S. mutans</em>).</div></div><div><h3>Methods</h3><div>A total of 75 children (6–13 years old) were randomly divided into five groups (n = 15) according to the type and concentration of the mouthwash as follows: group 1: negative control, tap water; group 2: positive control, chlorhexidine; group 3: 5% Indian Costus; group 4: 10% Indian Costus; group 5: 15% Indian Costus. Patients were instructed to rinse with 5 ml of the given mouthwash twice per day for 1 week. Non-stimulated saliva sample was collected before (baseline) and after 1 week of using the mouthwash. Microbiological examination was performed to assess <em>S. mutans</em> count in all samples. One-way ANOVA followed by Tukey post hoc test were used for statistical analysis and the significance level was set at <em>P</em> ≤ 0.05.</div></div><div><h3>Results</h3><div>Statistically significant differences were detected between baseline and post-rinse counts in all groups except for the negative control samples. The highest mean percentage of bacterial reduction was detected in group 5 (Costus 15%), whereas the lowest mean percentage of bacterial reduction was seen in group 1 (negative control, tap water).</div></div><div><h3>Conclusions</h3><div>This study offers preliminary evidence supporting the significant antimicrobial efficacy of Indian Costus extract mouthwash against <em>S. mutans</em>, a key biofilm-forming bacterium in the oral cavity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100997"},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of traditional Chinese medicine combined with conventional western medicine on metabolic syndrome: a Bayesian network meta-analysis","authors":"Yi Zhang,&nbsp;Yixuan Fang,&nbsp;Nannan Xing,&nbsp;Pengling Ge","doi":"10.1016/j.hermed.2025.100998","DOIUrl":"10.1016/j.hermed.2025.100998","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic syndrome (MetS) is a cluster of multiple risk factors. The combination of traditional Chinese medicine (TCM) and conventional western medicine (CWM) shows promise in treating MetS. However, the effectiveness of different integrated treatments combining TCM and CWM for MetS remains a subject of ongoing debate.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, Embase, Web of Science, and four Chinese databases were searched. We evaluated the risk of bias and quality in the included studies, and performed a Bayesian multiple network meta-analysis.</div></div><div><h3>Results</h3><div>We included 30 randomised controlled trials. Meta-analysis based on Bayesian network demonstrated that the combination of Dachaihu decoction and CWM exhibited the most excellent clinical treatment efficacy on MetS. The combination of HuanglianWendan decoction + Dachaihu decoction and CWM demonstrated the most favourable impact on improving patient body mass index (BMI); the combination of Gegen Qinlian decoction + Pingwei San and CWM exhibited a significant effect in reducing patient waist circumference; among various treatment measures, Wuling San combined with CWM had been proven to be more effective in enhancing high-density lipoprotein cholesterol (HDL-c) levels in patients.</div></div><div><h3>Conclusion</h3><div>The combination of TCM and CWM exhibits a pronounced therapeutic efficacy in the management of MetS, surpassing the use of CWM alone. This study identified the optimal intervention strategies for different outcome indicators by combining TCM and CWM in a comprehensive manner. However, due to the limitations of this study, more high-quality studies are needed to provide robust evidence in the future.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100998"},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated review on ethnobotanical insights, phytochemistry and pharmacological potentials of Homalomena aromatica Schott.: an important medicinal aromatic plant","authors":"Raghu Tamang ,&nbsp;Tanmita Gupta ,&nbsp;Twahira Begum ,&nbsp;Mohan Lal","doi":"10.1016/j.hermed.2025.100995","DOIUrl":"10.1016/j.hermed.2025.100995","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Homalomena aromatica</em> Schott., a member of Araceae family, is considered pivotal in both medicinal and aromatic purposes used by aromatic and perfumery industries throughout world. In the present review we have highlighted the ethnobotany, phytochemistry as well as biological activities with future pharmacological aspects of this medicinal species.</div></div><div><h3>Methods</h3><div>An extensive literature review was searched from Google Scholar, PubChem, Sciencedirect, Wiley online library and followed the PRISMA (2020) guidelines. The key words searched include <em>H. aromatica</em>, essential oil, pharmacological properties, biological activity and ethnobotany.</div></div><div><h3>Results</h3><div><em>H. aromatica</em> essential oil contains many important chemical constituents which includes linalool followed by terpinene-4 ol, α-terpinol, γ-terpine, α-cadinol, τ-cadinol, spathulenol, geraniol, nerol, etc. The residual material remaining after extracting essential oil finds extensive use in the production of incense (dhup). In addition to its aromatic qualities, the plant harbours medicinal attributes beneficial for treating a myriad of ailments. The rhizomes and leaves are frequently employed to alleviate pain and combat skin infections. Furthermore, the plant boasts diverse pharmacological properties including antispasmodic, antifungal, analgesic, antidepressant, sedative, anti-inflammatory activities.</div></div><div><h3>Conclusion</h3><div>This review offers a summary of the chemical composition and pharmacological applications of <em>H. aromatica</em>. Additionally, it sheds light on the plant's ethnobotanical uses, economic prospects, and potential avenues for future research in its diverse pharmacological applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100995"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urtica dioica for benign prostatic hyperplasia","authors":"Pawel Posadzki ,&nbsp;Chuenjid Kongkaew ,&nbsp;Edzard Ernst","doi":"10.1016/j.hermed.2025.100996","DOIUrl":"10.1016/j.hermed.2025.100996","url":null,"abstract":"<div><h3>Introduction</h3><div>As of 2019, globally, there were 94 million prevalent cases of benign prostatic hyperplasia. This systematic review evaluates the effectiveness of <em>Urtica dioica</em> as a treatment of benign prostatic hyperplasia (BPH).</div></div><div><h3>Methods</h3><div>MEDLINE, Embase, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and ClinicalTrials.gov were searched from databases inceptions to February 2024. Randomized clinical trials (RCTs) investigating <em>Urtica dioica</em> (with or without usual care) for treating BPH in human subjects were considered. The GRADE approach was used to evaluate the certainty of evidence.</div></div><div><h3>Results</h3><div>Six RCTs with a total of 1210 patients met the inclusion criteria. Risk of bias of the included studies was mostly unclear or high. Meta-analyses showed that, compared with controls (placebo, usual care), <em>Urtica dioica</em> improved slightly BPH symptoms measured with the International Prostate Symptom Score (IPSS) at follow-ups of up to 12 months (standardized mean difference [SMD] -2.06, 95% confidence intervals [CI] [-3.22, -0.91] very low certainty evidence), reduced prostate specific antigen (PSA) levels (mean difference [MD] -0.37 ng/ml, 95% CI [-0.50, -0.23] low certainty evidence) but the interventions had little effect on quality of life (SMD -0.59, 95% CI [-1.57, 0.38] very low certainty evidence). The main reasons for downgrading the evidence were study limitations, inconsistency, and imprecision. All six studies reported adverse-effects; stating that none had occurred.</div></div><div><h3>Conclusions</h3><div>There is some promising evidence to support the effectiveness of <em>Urtica</em> in reducing the symptoms of BPH. Future, larger and more rigorous studies might reduce the existing uncertainties.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100996"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of herbal medicine for cancer therapy in Indonesia: a prospective cohort study","authors":"Zulvikar Syambani Ulhaq ,&nbsp;Delima ,&nbsp;Lucie Widowati ,&nbsp;Pramita Andarwati ,&nbsp;Elga Renjana ,&nbsp;Elok Firdiana ,&nbsp;Lola Ayu Istifiani ,&nbsp;Syafrizal Aji Pamungkas","doi":"10.1016/j.hermed.2025.100991","DOIUrl":"10.1016/j.hermed.2025.100991","url":null,"abstract":"<div><h3>Introduction</h3><div>Herbal medicine is widely used in Indonesia, including for cancer treatment, but data on its effectiveness is limited. This study aimed to assess the effectiveness of herbal medicine in cancer patients by evaluating their wellness index (WI), compliance, and herb usage patterns.</div></div><div><h3>Methods</h3><div>Data were obtained from the <em>Jamu Registry</em> for the period from 2014 to 2018. The improvement in patients' health status was assessed by quantifying the WI score, a modification of the World Health Organization's (WHO’s) quality of life (QoL) measure. Additionally, drug compliance and patterns of commonly used herbs were also evaluated.</div></div><div><h3>Results</h3><div>This study involved 130 participants, 82.3% of whom were female, with 33% diagnosed with breast cancer. Preference for herbal medicine alone was associated with older age, lower education, and rural residence. The six most commonly prescribed herbs were <em>Andrographis paniculata</em>, <em>Catharanthus roseus</em>, <em>Curcuma zanthorrhiza</em>, <em>Gynura divaricata</em>, <em>Physalis angulata</em>, and <em>Centella asiatica</em>. Overall, 75.4% of patients improved their WI score, with greater improvement in those using only herbal medicine (81.9%) compared to complementary therapies (48%) (<em>P</em> = 0.001). Drug compliance was good, with 72.3% adhering to their regimen. <em>In silico</em> analysis highlighted anti-cancer properties in these herbs, with α-tocopherol from <em>P. angulata</em> and kaempferol-3-O-β-D-glucopyranoside from <em>G. divaricata</em> showing potent effects, modulated by ERα and MDM2, both linked to breast cancer.</div></div><div><h3>Conclusion</h3><div>Herbal medicine is widely regarded as a complementary and alternative treatment option for cancer patients in Indonesia. Our study further demonstrates that the use of herbal medicine contributes to an improvement in the overall well-being of these patients.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 100991"},"PeriodicalIF":2.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of milk thistle (Silybum marianum) phytochemicals as curative agents of retinoblastoma using in-silico approach","authors":"Ayesha Yasmin ,&nbsp;Muhammad Naveed Shahid ,&nbsp;Usman Arif ,&nbsp;Adil Jamal","doi":"10.1016/j.hermed.2025.100992","DOIUrl":"10.1016/j.hermed.2025.100992","url":null,"abstract":"<div><h3>Introduction</h3><div>Retinoblastoma is a malignant tumour that primarily affects children under the age of five. This cancer arises from retinoblasts, leading to a distinctive symptom known as leukocoria, which is a white reflection visible when light shines on the retina. Retinal cells proliferate uncontrollably as a result of mutations in the allele of the retinoblastoma gene (RB1) which indirectly cause overexpression of CDK4 and CDK6 proteins. Milk thistle has the ability to inhibit cancer cell growth, prevent angiogenesis, halt metastasis, induce apoptosis, and enhance effectiveness of chemotherapy and radiation treatments.</div></div><div><h3>Methods</h3><div>In this study, ligands were retrieved to investigate potential of milk thistle in treating retinoblastoma and it’s <em>in silico</em> interaction with CDK4, CDK6, and pRb proteins were assessed through molecular docking techniques. The drug-likeness of all ligands was assessed by Lipinski rule of five. The PyMOL program was used to convert PDB format of the CDK4, CDK6, and pRb receptors into PDBQT format, and to identify active sites on the proteins. The drug-ability, lead likeness, pharmacokinetics, and physicochemical properties of ligands were assessed using SwissADME.</div></div><div><h3>Results</h3><div>The drug-likeness of all ligands followed Lipinski's rule with no violations of any of the five parameters. The binding affinity of milk thistle ligands to CDK4, CDK6, and pRB proteins was found to be high ranging from −3 to −9.9 kcal/mol, suggesting the potential of milk thistle as a treatment for retinoblastoma. Milk thistle is a useful treatment option for cancer, because of its anti-proliferative, anti-angiogenisis, anti- metastasis and induce apoptosis properties. ADMET analysis provided insights into the oral bioavailability, pharmacokinetics, water solubility, and physicochemical properties of the ligands.</div></div><div><h3>Conclusions</h3><div>The findings indicated that phytochemicals derived from milk thistle hold promising potential as a therapeutic option for retinoblastoma due to its diverse mechanisms of action, positive safety profile, and prospective synergistic effects with conventional therapies.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100992"},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Puping Qinghua in the management of patients infected with SARS-CoV-2: a prospective, randomised, case-control study","authors":"Chenyang Liu ,&nbsp;Bin Chen ,&nbsp;Youhua Wang ,&nbsp;Wei Zhai ,&nbsp;Qixiang Song ,&nbsp;Hai Li ,&nbsp;Lei Qiu ,&nbsp;Duan Zhou ,&nbsp;Yingen Wu ,&nbsp;Min Cao","doi":"10.1016/j.hermed.2024.100977","DOIUrl":"10.1016/j.hermed.2024.100977","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese medicine (TCM) has demonstrated considerable clinical efficacy in treating coronavirus disease 2019 (COVID-19). Puping Qinghua prescription (PPQH), a traditional Chinese medicine formulation, was found to be effective against clinical symptoms in patients with Omicron variant virus infection, Nonetheless, its safety and mechanism are unclear.</div></div><div><h3>Purpose</h3><div>To provide evidence of validity and adverse events associated with PPQH in treating SARS-CoV-2 Omicron variants infection.</div></div><div><h3>Methods</h3><div>Four hundred and eighty patients diagnosed with COVID-19 were randomised into the PPQH group (n = 240) and the LLQW group (n = 240). Basic information such as age, sex, vaccination status, symptoms, etc were registered. Laboratory tests for 142 patients, including cytokine levels and lymphocyte counts, liver and kidney function.</div></div><div><h3>Results</h3><div>After intervention, levels of NK cells, IFN-α, IL-5, IL-6, and IL-12p70 were reduced in the PPQH group, whereas the levels of TNF-α, IL-1β, IL-4, IL-6, and IL-17A were reduced in the Lianhua Qingwen (LHQW) group (P &lt; 0.05). PPQH was more effective in shortening duration of fever and reducing degree of cough compared with LHQW (P &lt; 0.05). Liver and kidney functions remained unimpaired before and after intervention in both groups (P &gt; 0.05). In addition, the incidence of adverse reactions such as palpitations, dizziness and sweating was lower in the PPQH group (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The efficacy of PPQH is comparable to LHQW in patients infected with Omicron variant virus. More excitingly, PPQH demonstrates a higher level of security.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"49 ","pages":"Article 100977"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}