Guava (Psidium guajava) leverages platelets in dengue haemorrhagic fever in Indonesia: Bayesian and Frequentist ANCOVA recovered meta-analyses

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-07-02 DOI:10.1016/j.hermed.2025.101037

Jonathan, Theodorus Samuel Rahardja, Dede Fatmawati, Maudy Rahmi, Indah Ridhoila

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引用次数: 0

Abstract

Background

Tropical countries with humid climates and large populations, such as Indonesia, have a high prevalence of dengue haemorrhagic fever (DHF). The symptoms can range from mild fever to shock or even death. Spontaneous bleeding due to thrombocytopenia is one such example. Therefore, restoring thrombocyte levels is a key factor in DHF recovery. Contradictory evidence exists regarding the effects of guava (Psidium guajava) on thrombocytes in patients with DHF. In this study, we resolved this debate using Frequentist and Bayesian meta-analyses.

Methods

A comprehensive systematic review and meta-analysis of 972 articles from six databases, one registry, and a citation search from conception to 2024 identified seven studies after rigorous inclusion-exclusion filtration. All studies passed the quality assessment using the Risk of Bias 2 tool, Newcastle Ottawa Scale, and the risk of bias in non-randomised studies of interventions. Statistical analysis was performed using R version 4.4.2, analysis of covariance recovered effect size, Bayesmeta, and Metafor packages. Additionally, the authors used a DOI plot and the Luis Furuya-Kanamori index to assess publication bias.

Results

The current meta-analysis included seven studies with 234 subjects for the pre- and post-difference in platelet count with a control group contrast. Guava adequately increased the platelet count in DHF patients (63.21 [57.20–69.26] x 10³) in both adult and paediatric patients.

Conclusion

We summarise the role of guava in enhancing platelet counts in Indonesia. Guava fruit should be considered a complementary treatment alongside standard medicine for treating adult Indonesian patients with DHF in healthcare facilities and homes.

查看原文本刊更多论文

番石榴（Psidium guajava）在印度尼西亚登革热出血热中利用血小板：Bayesian和Frequentist ANCOVA恢复荟萃分析

气候潮湿、人口众多的热带国家，如印度尼西亚，登革热出血热（DHF）的流行率很高。症状从轻度发烧到休克甚至死亡。血小板减少症引起的自发性出血就是这样一个例子。因此，恢复血小板水平是DHF恢复的关键因素。关于番石榴（Psidium guajava）对DHF患者血小板的影响，存在相互矛盾的证据。在本研究中，我们使用频率分析和贝叶斯元分析解决了这一争论。方法对来自6个数据库、1个注册库和引文检索的972篇文章进行综合系统评价和meta分析，经过严格的纳入排除过滤，筛选出7篇研究。所有研究均通过了使用偏倚风险2工具、纽卡斯尔渥太华量表和干预措施的非随机研究的偏倚风险的质量评估。采用R 4.4.2进行统计分析，协方差分析恢复效应大小，Bayesmeta和Metafor软件包。此外，作者使用DOI图和Luis Furuya-Kanamori指数来评估发表偏倚。目前的荟萃分析包括7项研究，共234名受试者，与对照组相比，血小板计数前后的差异。番石榴可充分提高成人和儿童DHF患者的血小板计数（63.21 [57.20-69.26]× 103）。结论总结了番石榴在印度尼西亚提高血小板计数的作用。番石榴应被视为在卫生保健机构和家庭中治疗印度尼西亚成年登革出血热患者的补充药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.