Journal of Herbal Medicine最新文献

{"title":"Network Pharmacology and Molecular Docking Analysis Reveal the Therapeutic Potential of Artemisia annua L. in Systemic Lupus Erythematosus","authors":"Wenqin Huang ,&nbsp;Jinhe Xiong","doi":"10.1016/j.hermed.2025.101013","DOIUrl":"10.1016/j.hermed.2025.101013","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Artemisia annua L.</em>, a traditional Chinese herb, has been used to manage inflammatory diseases, including systemic lupus erythematosus (<strong>SLE</strong>). However, its active components and molecular mechanisms in treating SLE remain unclear.</div></div><div><h3>Methods</h3><div>Active compounds were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform with criteria of drug-likeness ≥0.18 and oral bioavailability ≥30%. SLE-related genes were retrieved from DrugBank, Online Mendelian Inheritance in Man, Therapeutic Target Database, and GeneCards using the search term ‘systemic lupus erythematosus.’ Protein–protein interaction networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins, and the Kyoto Encyclopaedia of Genes and Genomes and Gene Ontology enrichment analyses were performed via the DAVID platform. Molecular docking was conducted using AutoDock software.</div></div><div><h3>Results</h3><div>Eight core disease-related genes and five key active compounds were identified through topological analysis. Gene ontology and kyoto encyclopaedia of genes and genomes analyses indicated that the compounds primarily influenced cancer development risk, negative regulation of cell death, and related signalling pathways. Molecular docking confirmed strong binding affinities between key phytochemicals and core SLE targets .</div></div><div><h3>Conclusions</h3><div>The active compounds identified in this study target the following genes: interleukin-6, tumour protein p53, epidermal growth factor receptor, protein kinase B, interleukin-1 beta, tumour necrosis factor, jun proto-oncogene, and B-cell lymphoma 2, which regulate inflammation, T-cell differentiation, and apoptosis. These findings suggest <em>Artemisia annua L.</em> is a source of multitarget therapeutic agents for SLE, warranting further experimental validation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101013"},"PeriodicalIF":2.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Triphalakatakanpathadi Kashaya on glycaemic control and quality of life in type 2 diabetes mellitus in Sri Lankan population – A descriptive observational study","authors":"A.M.H.S. Attanayake ,&nbsp;A. Upadhyay ,&nbsp;R.P. Mendis ,&nbsp;C.P. Kahingalage ,&nbsp;W. Weerapana ,&nbsp;A.K. Sahu ,&nbsp;U.M.G.D. De Silva","doi":"10.1016/j.hermed.2025.101014","DOIUrl":"10.1016/j.hermed.2025.101014","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetes mellitus (DM) presents a significant global health burden, often leading to complications and reduced quality of life. Ayurveda, a traditional system of medicine practiced globally, often uses <em>Kashaya</em> (herbal decoctions) for the management of diabetes.</div></div><div><h3>Aim</h3><div>This article aims to assess the effect of <em>Triphalakatakanpathadi Kashaya</em> (TKPK) on glycemic control and quality of life in patients with type 2 diabetes.</div></div><div><h3>Material and methods</h3><div>A descriptive observational study was conducted involving 46 patients treated with TKPK for six months at Bandaranaike Memorial Ayurveda Research Institute (BMARI), Sri Lanka. Data on glycemic parameters, diabetes related signs and symptoms, and quality of life using the short form of quality of life questionnaire (SF-36) were collected and analyzed using paired t-test, and Wilcoxon signed rank test.</div></div><div><h3>Results</h3><div>TKPK led to significant reduction in mean baseline value of HbAIc from 7.11% to 6.58% (<em>p</em> &lt; 0.05) and mean baseline fasting blood sugar level from 172.4 ± 6.03 mg/dl to 141.4±4.99 mg/dl (<em>p</em> &lt; 0.05) after six months. Significant improvements (<em>p</em> &lt; 0.05) were observed in diabetes related signs and symptoms. Transaminases (AST &amp; ALT) and serum creatinine levels remained within normal ranges throughout the study period reflecting the safety of TKPK. Quality of life was enhanced significantly (<em>p</em> &lt; 0.05) in all the patients.</div></div><div><h3>Conclusion</h3><div>TKPK demonstrates the efficacy to lower blood glucose and improve the quality of life in type 2 DM patients. Scientific evidence of TKPK’s ingredients, suggest anti-inflammatory and anti-oxidant properties as contributing factors for its hypoglycemic effect. However, observational study imposes limitations, and warrant further clinical trials to establish the efficacy of this formulation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101014"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Pueraria lobata radix-containing traditional Chinese medicine in the treatment of essential hypertension: a systematic review","authors":"Xiangmin Deng ,&nbsp;Qiuyun Xue ,&nbsp;Xianjie Feng ,&nbsp;Haoyu Wang ,&nbsp;Ping Luo ,&nbsp;Yaqi Tian ,&nbsp;Rui Zhang ,&nbsp;Gaochuan Zhang ,&nbsp;Dongmei Yan ,&nbsp;Xu Zhou","doi":"10.1016/j.hermed.2025.101010","DOIUrl":"10.1016/j.hermed.2025.101010","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to systematically review the efficacy and safety of <em>Pueraria lobata radix</em> (Chinese name: Ge Gen) prescriptions (GGPs) of traditional Chinese medicine in treating hypertension.</div></div><div><h3>Methods</h3><div>We searched seven databases for randomised controlled trials (RCTs) comparing GGPs plus antihypertensive drugs versus antihypertensive drugs alone for essential hypertension. Primary outcomes were changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP), while secondary outcomes included 24hSBP, 24hDBP, responses to antihypertensive treatment, control of hypertensive symptoms, blood glucose and lipid indicators, and incidence of adverse events.</div></div><div><h3>Results</h3><div>Thirty-one RCTs involving 2<!--> <!-->501 patients were included. Compared with antihypertensive drugs alone, GGP adjuvant therapy significantly reduced SBP (mmHg) (mean difference [MD] −10.70, 95% confidence interval [CI] −12.75 to −8.65), DBP (MD −6.78, 95% CI −8.51 to −5.05), and 24hSBP (MD −7.13, 95% CI −10.78 to −3.47), increased the response to antihypertensive treatment (risk ratio 1.21, 95% CI 1.13–1.30) and hypertensive symptom control, and improved levels of total and low-density lipoprotein cholesterol, triglycerides, and blood glucose indicators. However, GGPs had no significant impact on high-density lipoprotein cholesterol (HDL-C) or 24hDBP, although the trial sequential analysis suggested false negatives for these outcomes.</div></div><div><h3>Conclusion</h3><div>GGPs, when used as complementary therapy, may improve various parameters related to blood pressure, blood lipids, and blood glucose in patients with essential hypertension and show good safety. However, the impact of GGPs on 24hDBP, hypertensive symptoms, and HDL-C remains uncertain due to the limited quality of evidence.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101010"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicinal survey of antidiabetic plants used by six indigenous communities in Sarawak, Borneo","authors":"Keeren Sundara Rajoo ,&nbsp;Philip Lepun ,&nbsp;Beatrice Lyeja Anak Kayok ,&nbsp;Nurul Azwany Umayrah ,&nbsp;Nazariena Abdullah","doi":"10.1016/j.hermed.2025.101011","DOIUrl":"10.1016/j.hermed.2025.101011","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarawak, located in one of the planet's most ecologically diverse regions, hosts over 30 distinct sub-ethnic groups, each with its own set of cultural, linguistic, and lifestyle distinctions. This has fostered the development of numerous, unique ethnobotanical traditions. Thus, this study aimed to document the antidiabetic ethnomedicinal knowledge of six indigenous communities and to examine how their cultural practices and beliefs influenced their respective approaches to managing diabetes.</div></div><div><h3>Methods</h3><div>Fieldwork was carried out between 2021 and 2024, engaging 231 herbal medicine practitioners from six Sarawak indigenous groups: Kenyah (n = 24), Melanau Igan (n = 71), Kayan (n = 30), Iban (n = 81), Punan (n = 13), and Baketan (n = 12). Ethnobotanical information was gathered using face-to-face interviews through both unstructured and semi-structured methods.</div></div><div><h3>Results</h3><div>The study documented 34 plant species utilised for diabetes treatment across five of the six communities, with 127 total use-reports. <em>Annona muricata</em> emerged as the most frequently cited species, with 22 use-reports spanning four communities, followed by <em>Orthosiphon aristatus</em> with 14 use-reports from two communities. Substantial differences were noted in traditional knowledge transmission, with rates ranging from 25% in the Kenyah to 91.5% in the Melanau Igan. Plant knowledge similarity between communities ranged from 0% to 35.29%, the highest similarity observed between the Kenyah and Iban.</div></div><div><h3>Discussion/Conclusions</h3><div>This study documents the distribution and transmission of antidiabetic plant knowledge within Sarawak's indigenous populations, with significant variations in species utilisation and knowledge preservation across communities. The quantified differences in knowledge transmission rates and practitioner expertise indicate varying levels of traditional knowledge preservation among the studied groups.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101011"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Chinese Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-analysis","authors":"Jiaqian Zuo ,&nbsp;Peipei Yang ,&nbsp;Xiaotao Niu ,&nbsp;Qiurong Li ,&nbsp;Wenqin Ren ,&nbsp;Yujie Huang ,&nbsp;Peng Shu","doi":"10.1016/j.hermed.2025.101009","DOIUrl":"10.1016/j.hermed.2025.101009","url":null,"abstract":"<div><h3>Introduction</h3><div>It is estimated that about 30% of patients who received chemotherapy will develop chemotherapy-induced peripheral neuropathy (<strong>CIPN</strong>). Chinese herbal medicine is widely used to treat CIPN in China, but its efficacy has not been investigated. Our study aims to review the current literature on the effectiveness of oral herbal medicine in controlling the symptoms of CIPN.</div></div><div><h3>Methods</h3><div>Up until July 2024, relevant international databases were searched. Chemotherapy-induced peripheral neuropathy treated with oral Chinese herbal medicine in randomised controlled trials was included. The effective rate of the improving grade of peripheral nerve injury, nerve conduction velocity, Karnofsky performance score (<strong>KPS</strong>), and traditional Chinese medicine (<strong>TCM</strong>) syndrome efficiency were the outcomes; the increase in ALT, AST, and the incidence of vomiting were used as safety indicators.</div></div><div><h3>Results</h3><div>This review included 14 articles. The overall effect of oral Chinese herbal medicine on CIPN is statistically significant, suggesting that herbal medicine can benefit patients suffering from CIPN. The intervention group shows significant differences in the effective rate of improving the grade of peripheral nerve injury (<em>P</em>＜0.05), sensory nerve conduction velocity (<em>P</em> ≤ 0.05), KPSs (<em>P</em>＜0.05), and the TCM syndrome efficiency (<em>P</em>＜0.05) when compared with the control groups. However, the motor nerve conduction velocity (<em>P</em>＞0.05) shows no statistically significant difference.</div></div><div><h3>Conclusions</h3><div>Oral Chinese herbal medicine is an effective method to relieve CIPN symptoms and can increase the effective rate of improving the grade of peripheral nerve injury, sensory nerve conduction velocity, KPSs, and TCM syndrome efficiency, and it has a good security.</div></div><div><h3>Prospero</h3><div>CRD42023493091.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101009"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and anti-inflammatory effects of Thunbergia laurifolia Lindl., Moringa oleifera Lam. and Phyllanthus amarus Schumach. & Thonn. extracts","authors":"Atittaya Rocejanasaroj,&nbsp;Potjaman Pumeesat,&nbsp;Julaluk Noiphung,&nbsp;Piya Wongyanin","doi":"10.1016/j.hermed.2025.101007","DOIUrl":"10.1016/j.hermed.2025.101007","url":null,"abstract":"<div><h3>Introduction</h3><div>There is increasing evidence suggesting that chronic inflammation in the gastrointestinal tract may be caused by pathogenic infections, leading to destructive inflammatory conditions such as periodontal disease. This study aimed to investigate the antimicrobial and anti-inflammatory properties of ethanolic extracts from <em>Thunbergia laurifolia</em> Lindl. (TLE), <em>Phyllanthus amarus</em> Schumach. &amp; Thonn. (PAE), and <em>Moringa oleifera</em> Lam. (MOE).</div></div><div><h3>Methods</h3><div>The antimicrobial activity of crude ethanol extracts was assessed using disk diffusion and broth dilution methods against <em>Bacillus cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa</em>, and <em>Vibrio cholerae</em>. The anti-inflammatory properties of herbal extracts by measuring the level of interleukin-6 (IL-6), tumour necrosis factor-alpha, and monocyte chemoattractant protein-1 (MCP-1) secretion in THP-1 macrophage cells over 24 hours, both in the absence and presence of lipopolysaccharide.</div></div><div><h3>Results</h3><div>All herbal extracts exhibited antibacterial activity against <em>B. cereus</em>, <em>S. aureus</em>, and <em>V. cholerae</em>, but were ineffective against <em>E. coli</em> and <em>P. aeruginosa</em>. The inhibitory effects were dose-dependent, with minimum inhibitory concentration (MIC) values ranging from 625 to 5<!--> <!-->000 µg/ml and minimum bactericidal concentration values ranging from 625 to 10<!--> <!-->000 µg/ml. MOE showed the highest antibacterial activity against <em>V. cholerae</em> (MIC = 625 µg/ml), while PAE exhibited the most inhibitory effects against <em>B. cereus</em> (MIC = 625 µg/ml). Additionally, PAE and TLE as low as 200 µg/ml completely inhibit IL-6 secretion and reduce Tumor Necrosis Factor-alpha (TNF-α) and MCP-1 secretion in a concentration-dependent manner.</div></div><div><h3>Conclusions</h3><div>All three herbal extracts have the potential to attenuate the secretion of inflammatory cytokines and exhibit antibacterial activity that may prevent foodborne infections.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101007"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-analysis of Randomised Controlled Trials on Curcumin-Piperine Supplementation: A Promising Strategy for Managing Lipid Profiles and Liver Health in Non-alcoholic Fatty Liver Disease","authors":"Maryam Gholami Shahrebabak ,&nbsp;Seyed Payam Shahabi Haghighi ,&nbsp;Mahdi Ravankhah ,&nbsp;Alireza Zare ,&nbsp;Vahid Bazyari ,&nbsp;Bahareh Izadi","doi":"10.1016/j.hermed.2025.101006","DOIUrl":"10.1016/j.hermed.2025.101006","url":null,"abstract":"<div><h3>Introduction</h3><div>NAFLD, including simple fatty liver and steatohepatitis, is a widespread condition, driving research into its treatment. This meta-analysis assesses curcumin and piperine effects on lipids and liver enzymes in adults with fatty liver.</div></div><div><h3>Methods</h3><div>A comprehensive search of various databases (Cochrane, Pubmed, Scopus, Web of Science, Embase) identified a total of 1 419 articles up to September 1, 2024. We used subgroup and sensitivity analyses to detect the source of heterogeneity.</div></div><div><h3>Results</h3><div>Six studies met the inclusion criteria after thorough screening. Primary outcomes assessed included lipid levels (low-density lipoprotein, triglycerides, high-density lipoprotein, total cholesterol) and liver enzymes (aspartate aminotransferase, alanine aminotransferase), alongside the severity of NAFLD. The result of meta-analysis indicated that curcumin-piperine supplementation led to significant reductions in triglycerides (weighted mean difference [<strong>WMD</strong>] = −8.27 mg/dl, <em>P</em> &lt; 0.05) and elevated high-density lipoprotein-C levels (WMD = 2.14 mg/dl, <em>P</em> &lt; 0.05). Although non-significant reductions were observed for total cholesterol and low-density lipoprotein-C, aspartate aminotransferase levels significantly decreased (WMD = −1.73 IU/L, <em>P</em> &lt; 0.05), while alanine aminotransferase showed a non-significant decline. Notably, the severity of NAFLD significantly decreased in grade 3 patients (odds ratio = 0.34; 95% CI: 0.14–0.83).</div></div><div><h3>Conclusions</h3><div>Curcumin-piperine supplementation shows promise in managing liver impairment and lipid abnormalities in NAFLD patients. However, limitations such as the small number of studies and heterogeneity in protocols highlight the need for larger, well-designed trials. While no universally approved pharmacotherapy for NAFLD exists, curcumin-piperine may serve as a complementary or alternative option, warranting further investigation to optimise its therapeutic potential.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101006"},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicinal Plants Used for Skin Care in Sirmour District of Himachal Pradesh (India)","authors":"Parul Singhal ,&nbsp;Preeti Dobhal","doi":"10.1016/j.hermed.2025.101004","DOIUrl":"10.1016/j.hermed.2025.101004","url":null,"abstract":"<div><h3>Introduction</h3><div>The study aimed to explore the Indigenous knowledge regarding the utilisation of medicinal plants for curing skin diseases in rural pockets of Sirmour district of Himachal Pradesh as the study area was unexplored till date. The main purpose of the study is to unfold the asset of traditional medicinal plants and make it accessible to others for further usage.</div></div><div><h3>Methods</h3><div>Facts on ethnomedicinal plants were recorded after the intensive field visits and surveys of 390 households of 69 villages using semistructured interviews and group discussions by standard questionnaires. All the collected data were analysed by informant consensus factor, fidelity level, use value, and relative frequency citation.</div></div><div><h3>Results</h3><div>The current research reported 73 ethnomedicinal plants of 39 families being utilised in skin cure. Maximum used method of preparation includes poultice (44.16%) while the utmost plants are used for curing injuries, cuts, and wounds (27%). The highest informant consensus factor value 0.93 was reported for ringworm disease. The highest fidelity level was reported for <em>Euphorbia hirta</em> (77.63%). In the study, 18 plants for curing skin ailments were reported for the first time.</div></div><div><h3>Conclusions</h3><div>These findings indicate that utilisation of Indigenous traditional herbal medicine is a well-established practice in Sirmour district to explore the original vicinity. However, plants were reported to be used unsustainably. The observation generated by this research creates scientific curiosity regarding further studies to assess the efficacy with modern assays, which will provide substantive benefits to society.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 101004"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional herbal practices associated with malaria and symptoms: Mishmi tribe cohort study from Arunachal Pradesh, Northeast India","authors":"Simi Talukdar","doi":"10.1016/j.hermed.2025.101002","DOIUrl":"10.1016/j.hermed.2025.101002","url":null,"abstract":"<div><h3>Introduction</h3><div>The <em>Miju-Mishmi</em> tribe of Lohit district, Arunachal Pradesh has a long-standing tradition of utilising herbal remedies for treating various ailments, including malaria. This study aimed to explore the antimalarial plants traditionally utilised by the <em>Miju-Mishmi</em> tribe, their preparation methods, and the biological significance of these remedies through phytopharmacological analysis.</div></div><div><h3>Methods</h3><div>The three villages of Karhe, Ziro Basti and Telluliang in Arunachal Pradesh were selected as study sites which spanned from April 2020 to July 2021. A group of people, including knowledgeable elders, traditional healers, herb vendors, and patients, who had been treated, were interviewed using semi-structured interviews and focus groups. In order to measure the efficacy and popularity of medicinal plants, ethnobotanical indices were computed. These included Fidelity Level, Preference Ranking, Use Value, Informant Consensus Factor, and Formulation Score.</div></div><div><h3>Results and discussion</h3><div>A total of 79 medicinal plants from 50 families and 71 genera, with 24 plants being newly identified for their antimalarial properties. Predominantly, leaves (30.38%) of herbaceous species (48.10%) were commonly used, with direct oral consumption being the highest preferred mode of administration (83.54%), primarily through extraction (25.81%) and decoction (22.58%). Notably, <em>Aconitum heterophyllum</em> demonstrated the highest fidelity value (≥80%), while <em>Coptis teeta</em> exhibited the highest Preference Ranking (≥65%). The Use Value index ranged from 0.07 to 0.87. Qualitative phytochemical profiling of selected plants confirmed their therapeutic efficacy against malaria.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 101002"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey Exploration of Some Plants Used in Managing Hypertension in the North Central States of Nigeria","authors":"Otaru Audu Isah ,&nbsp;MacDonald Idu ,&nbsp;Ogunma Benjamin Gabriel","doi":"10.1016/j.hermed.2025.100994","DOIUrl":"10.1016/j.hermed.2025.100994","url":null,"abstract":"<div><h3>Introduction</h3><div>This study entails surveying and documenting information on the traditional management of hypertension using medicinal plants among people in the North Central States of Nigeria.</div></div><div><h3>Methods</h3><div>Ethnomedicinal survey was conducted across the region using questionnaires, tape recorders and interpreters. Questionnaires were administered to 180 respondents in 200 locations. The generic and family names of each plant species were documented following authentication.</div></div><div><h3>Results</h3><div>Seventy-two (72) medicinal plant species belonging to 65 genera and 45 families were cited from 180 respondents of which 107 were traditional healers. Respondents reported that inheritance (104 informants) and apprenticeship (56 informants) were the two modes of indigenous knowledge acquisition. The frequency of use of each plant species as a folkloric antihypertensive agent revealed that <em>Anacardium occidentale</em> has the lowest use value and fidelity level (0.57, 14.29), while <em>Moringa oleifera</em> has the highest use value and fidelity level (0.95, 90.00), respectively. The family Rubiaceae has the highest representation of plant species (7.04%). Most plants were wild (46.48%), and herbs had the most significant representation (42.25%). The preferred mode of administration of traditional medicine was oral, and the dosage regimen was 30 ml three times daily. Most of the respondents were aged between 41 and 50.</div></div><div><h3>Conclusions</h3><div>This study documents antihypertensive plants used among the indigenous communities within the North Central States of Nigeria. The unevaluated plants may be a viable reservoir of alternative sources of antihypertensive drug development.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100994"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}