Journal of Herbal Medicine最新文献

{"title":"Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking","authors":"Raden Bayu Indradi ,&nbsp;Muhaimin Muhaimin ,&nbsp;Melisa Intan Barliana ,&nbsp;Alfi Khatib ,&nbsp;Intan Timur Maisyarah ,&nbsp;Dian Ayu Eka Pitaloka ,&nbsp;Muhammad Fadhil Pratomo","doi":"10.1016/j.hermed.2025.101021","DOIUrl":"10.1016/j.hermed.2025.101021","url":null,"abstract":"<div><h3>Introduction</h3><div>Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as <em>Physalis angulata</em>, need to be studied for their claimed efficacy to treat malaria.</div></div><div><h3>Methods</h3><div>In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of <em>P. angulata</em> to alleviate malaria, as confirmed by molecular docking.</div></div><div><h3>Results</h3><div>The result revealed that 25 compounds of <em>P. angulata</em> interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that withangulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4.</div></div><div><h3>Conclusion</h3><div>We predict that <em>P. angulata</em> alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101021"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Screening of Four Medicinal Lamiaceae Plants, Two of Which Are Endemic to Türkiye: Apoptotic and Cytotoxic Characteristics","authors":"Arzu KASKA ,&nbsp;Mücahit SEÇME","doi":"10.1016/j.hermed.2025.101020","DOIUrl":"10.1016/j.hermed.2025.101020","url":null,"abstract":"<div><h3>Introduction</h3><div>Lamiaceae plants possess anticancer, antioxidant, and antimicrobial activities due to their phytochemical constituents. The aim of this study is to investigate the effects of the hydroethanolic extracts of four medicinal Lamiaceae plants (<em>Thymus zygioides, Teucrium sandrasicum, Origanum sipyleum, Nepeta italica</em> subsp. <em>cadmea</em>) to apoptosis and cell cycle on MDA-MB-231 breast cancer cell line.</div></div><div><h3>Methods</h3><div>The cytotoxic effects of hydroethanolic extracts of these medicinal Lamiaceae plants on cell viability in the MDA-MB-231 cell line were determined by XTT assay. mRNA expression changes of apoptosis and cell-cycle checkpoint regulators (Bax, Bcl-2, H19, RNU43, caspase-3, caspase-8, caspase-9, cyclin D1, CDK 4, CDK 6) were evaluated by real-time PCR.</div></div><div><h3>Results</h3><div>The hydroethanolic extracts from four medicinal Lamiaceae plants have exhibited high antiproliferative activity in MDA-MB-231 breast cancer cells according to time and concentration-dependent manner.</div></div><div><h3>Conclusions</h3><div>The potential application of these Lamiaceae medicinal plants as an antiproliferative agent is an important step in understanding the medicinal use of plants in Türkiye.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101020"},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study on Practitioners Participating in the COVID-19 Telemedicine Centre of Korean Medicine","authors":"Hye-Young Jang ,&nbsp;Seung-Yeon Jeong ,&nbsp;Eun-Kyoung Lee ,&nbsp;Song-Yi Kim","doi":"10.1016/j.hermed.2025.101017","DOIUrl":"10.1016/j.hermed.2025.101017","url":null,"abstract":"<div><h3>Introduction</h3><div>This qualitative study explored the integration of Korean medicine, particularly herbal medicine, in non-face-to-face care during the rapid increase in coronavirus disease 2019 patients in South Korea. This initiative was implemented voluntarily without governmental support.</div></div><div><h3>Methods</h3><div>We conducted in-depth interviews with twelve Korean medicine doctors from the Korean Medicine Telemedicine Centres in Daegu and Seoul, analysing the data using qualitative content analysis.</div></div><div><h3>Results</h3><div>The findings were categorised into four themes: (1) establishment of the Korean Medicine Telemedicine Centre amidst the conflict between Korean and Western medicine and a strong internal motivation; (2) patients as viewed by Korean medicine doctors and what patients want from Korean medicine treatment; (3) hope and the value of Korean medicine found again through new experience; (4) changes to be prepared for future Korean medicine to take a step forward.</div></div><div><h3>Conclusions</h3><div>This study highlights the potential of Korean medicine telemedicine as a viable healthcare model beyond the coronavirus disease 2019 pandemic, addressing both its opportunities and challenges in infectious disease management. To ensure its long-term integration, future efforts should focus on developing standardised treatment protocols, advancing telemedicine technologies, and fostering collaboration between Korean medicine and Western medicine within a more inclusive healthcare system.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101017"},"PeriodicalIF":2.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aloe ferox, Agathosma betulina, and Bulbine frutescens Extracts Show Antifungal Activity at Concentrations Favourable to the Proliferation of Epidermal Cells","authors":"Banele Ndlovu ,&nbsp;Jeremy Klaasen ,&nbsp;Pedro Abrantes ,&nbsp;Charlene Africa ,&nbsp;Farzana Fisher (née Rahiman)","doi":"10.1016/j.hermed.2025.101019","DOIUrl":"10.1016/j.hermed.2025.101019","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasing prevalence of antifungal resistance presents an enormous challenge to healthcare professionals. The adverse effects and resistance of current antifungal drugs have prompted the need for alternate antifungal therapy in the form of natural products. Although anecdotal reports have suggested that <em>Aloe ferox</em>, <em>Agathosma betulina,</em> and <em>Bulbine frutescens</em> have been used to successfully treat fungal skin infections, little scientific evidence is available to validate these claims. Therefore, this study aimed to determine whether the concentrations of <em>A ferox</em>, <em>A betulina,</em> and <em>B frutescens</em> hydroethanolic extracts showing antifungal activity against skin-related <em>Candida</em> species are cytotoxic to normal human epidermal cells.</div></div><div><h3>Methods</h3><div>Crystal violet and lactate dehydrogenase assays were employed to determine cell viability and cytotoxicity on the human epidermal cells. Broth microdilutions were performed to evaluate the susceptibility of <em>Candida</em> species to plant extracts.</div></div><div><h3>Results</h3><div><em>Candida</em> spp. inhibition was observed at a concentration of 200 µg/ml, while optimum extract concentrations for cell proliferation ranged between 200 and 400 µg/ml for <em>B frutescens</em> and 200 µg/ml for <em>A ferox</em> and <em>A betulina</em>. This suggests that these plants could prove to be effective as antifungal agents at a dosage of 200 µg/ml while still supporting the growth of epidermal cells at the same concentration, which is an important process in maintaining healthy skin.</div></div><div><h3>Conclusions</h3><div>These findings from this study lay a foundation for further studies confirming the applicability of these medicinal plants as safe alternative antifungal treatments that promote skin cell proliferation, regeneration, and enhance tissue repair.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101019"},"PeriodicalIF":2.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Vaccination and Herbal Supplement Usage Preferences Among African Populations During Coronavirus Disease 2019 Pandemic: A Scoping Review","authors":"A.A. Onyeaghala ,&nbsp;A.F. Anyiam ,&nbsp;D.C. Husaini ,&nbsp;J.H. Chiroma ,&nbsp;O.C. Arinze-Anyiam","doi":"10.1016/j.hermed.2025.101016","DOIUrl":"10.1016/j.hermed.2025.101016","url":null,"abstract":"<div><h3>Introduction</h3><div>The coronavirus disease 2019 (<strong>COVID-19</strong>) pandemic has driven global mitigation efforts, including vaccination campaigns and the exploration of herbal supplements. In Africa, where diverse cultural and healthcare landscapes vary, understanding the preferences and perceptions surrounding the use of vaccination and herbal supplements is crucial for effective public health interventions. This study aims to examine vaccination and herbal supplement usage preferences among African populations during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A scoping review synthesised literatures on vaccination and herbal supplement preferences. Searches were conducted in Google Scholar, PubMed, ResearchGate, and Embase for studies published in English between January 2020 and December 2023. Relevant themes and patterns were identified through data extraction and synthesis</div></div><div><h3>Results</h3><div>Attitudes towards vaccination varied and were influenced by factors such as vaccine hesitancy, mistrust in healthcare systems, cultural beliefs, and misinformation. Additionally, the use of herbal supplements was widespread, driven by cultural practices, accessibility, and perceived efficacy in COVID-19 prevention or treatment</div></div><div><h3>Conclusions</h3><div>This study highlights the complex interplay of factors shaping vaccination and herbal supplement preferences in Africa during the COVID-19 pandemic. Insights from this analysis can inform tailored interventions and policies to address COVID-19 and future public health challenges in Africa.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101016"},"PeriodicalIF":2.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eladi Churna and Draksharishta Improve Clinical Features and Functional Status of Lungs in Patients With Stable Chronic Bronchitis","authors":"H. Singh ,&nbsp;B. Yadav ,&nbsp;R.K. Ravte ,&nbsp;S. Baheti ,&nbsp;P.G. Nair ,&nbsp;B.C.S. Rao ,&nbsp;R. Rana ,&nbsp;R. Singhal ,&nbsp;N. Srikanth ,&nbsp;R. Acharya","doi":"10.1016/j.hermed.2025.101015","DOIUrl":"10.1016/j.hermed.2025.101015","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic bronchitis (<strong>CB</strong>) is a common pulmonary disease that is a significant cause of morbidity and mortality worldwide, and better healthcare approaches are still needed. As such, <em>Ayurvedic</em> therapies must be explored to manage CB. The purpose of this trial was to examine and validate the clinical efficacy and safety of <em>Eladi Churna</em> and <em>Draksharishta</em> for the management of stable CB.</div></div><div><h3>Methods</h3><div>A total of 130 participants with stable CB were registered in this study, out of which 110 participants completed the trial. <em>Eladi Churna</em> was given orally in a dose of 3 g thrice a day with honey after food. <em>Draksharishta</em> was administered orally in a dose of 20 ml twice daily for 84 days with an equal quantity of water after food.</div></div><div><h3>Results</h3><div>The effectiveness and safety of Ayurvedic therapy were assessed using clinical characteristics, the forced expiratory volume in 1 s score and the peak expiratory flow rate, the Leicester cough questionnaire score, the St George's respiratory questionnaire score, and hematological and biochemical investigations which were measured at the initiation of the trial and after completion of the trial. Clinical characteristics, forced expiratory volume in 1 s score, peak expiratory flow rate, Leicester cough questionnaire score, and St George's respiratory questionnaire scores were improved significantly with these trial medicines. The results showed that the participants who consumed these medicines had no adverse side effects.</div></div><div><h3>Conclusions</h3><div><em>Eladi Churna</em> and <em>Draksharishta</em> is beneficial and safe in long-term use to improve the clinical features and functional status of the lungs of patients with CB.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101015"},"PeriodicalIF":2.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology and Molecular Docking Analysis Reveal the Therapeutic Potential of Artemisia annua L. in Systemic Lupus Erythematosus","authors":"Wenqin Huang ,&nbsp;Jinhe Xiong","doi":"10.1016/j.hermed.2025.101013","DOIUrl":"10.1016/j.hermed.2025.101013","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Artemisia annua L.</em>, a traditional Chinese herb, has been used to manage inflammatory diseases, including systemic lupus erythematosus (<strong>SLE</strong>). However, its active components and molecular mechanisms in treating SLE remain unclear.</div></div><div><h3>Methods</h3><div>Active compounds were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform with criteria of drug-likeness ≥0.18 and oral bioavailability ≥30%. SLE-related genes were retrieved from DrugBank, Online Mendelian Inheritance in Man, Therapeutic Target Database, and GeneCards using the search term ‘systemic lupus erythematosus.’ Protein–protein interaction networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins, and the Kyoto Encyclopaedia of Genes and Genomes and Gene Ontology enrichment analyses were performed via the DAVID platform. Molecular docking was conducted using AutoDock software.</div></div><div><h3>Results</h3><div>Eight core disease-related genes and five key active compounds were identified through topological analysis. Gene ontology and kyoto encyclopaedia of genes and genomes analyses indicated that the compounds primarily influenced cancer development risk, negative regulation of cell death, and related signalling pathways. Molecular docking confirmed strong binding affinities between key phytochemicals and core SLE targets .</div></div><div><h3>Conclusions</h3><div>The active compounds identified in this study target the following genes: interleukin-6, tumour protein p53, epidermal growth factor receptor, protein kinase B, interleukin-1 beta, tumour necrosis factor, jun proto-oncogene, and B-cell lymphoma 2, which regulate inflammation, T-cell differentiation, and apoptosis. These findings suggest <em>Artemisia annua L.</em> is a source of multitarget therapeutic agents for SLE, warranting further experimental validation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101013"},"PeriodicalIF":2.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Triphalakatakanpathadi Kashaya on glycaemic control and quality of life in type 2 diabetes mellitus in Sri Lankan population – A descriptive observational study","authors":"A.M.H.S. Attanayake ,&nbsp;A. Upadhyay ,&nbsp;R.P. Mendis ,&nbsp;C.P. Kahingalage ,&nbsp;W. Weerapana ,&nbsp;A.K. Sahu ,&nbsp;U.M.G.D. De Silva","doi":"10.1016/j.hermed.2025.101014","DOIUrl":"10.1016/j.hermed.2025.101014","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetes mellitus (DM) presents a significant global health burden, often leading to complications and reduced quality of life. Ayurveda, a traditional system of medicine practiced globally, often uses <em>Kashaya</em> (herbal decoctions) for the management of diabetes.</div></div><div><h3>Aim</h3><div>This article aims to assess the effect of <em>Triphalakatakanpathadi Kashaya</em> (TKPK) on glycemic control and quality of life in patients with type 2 diabetes.</div></div><div><h3>Material and methods</h3><div>A descriptive observational study was conducted involving 46 patients treated with TKPK for six months at Bandaranaike Memorial Ayurveda Research Institute (BMARI), Sri Lanka. Data on glycemic parameters, diabetes related signs and symptoms, and quality of life using the short form of quality of life questionnaire (SF-36) were collected and analyzed using paired t-test, and Wilcoxon signed rank test.</div></div><div><h3>Results</h3><div>TKPK led to significant reduction in mean baseline value of HbAIc from 7.11% to 6.58% (<em>p</em> &lt; 0.05) and mean baseline fasting blood sugar level from 172.4 ± 6.03 mg/dl to 141.4±4.99 mg/dl (<em>p</em> &lt; 0.05) after six months. Significant improvements (<em>p</em> &lt; 0.05) were observed in diabetes related signs and symptoms. Transaminases (AST &amp; ALT) and serum creatinine levels remained within normal ranges throughout the study period reflecting the safety of TKPK. Quality of life was enhanced significantly (<em>p</em> &lt; 0.05) in all the patients.</div></div><div><h3>Conclusion</h3><div>TKPK demonstrates the efficacy to lower blood glucose and improve the quality of life in type 2 DM patients. Scientific evidence of TKPK’s ingredients, suggest anti-inflammatory and anti-oxidant properties as contributing factors for its hypoglycemic effect. However, observational study imposes limitations, and warrant further clinical trials to establish the efficacy of this formulation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101014"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Pueraria lobata radix-containing traditional Chinese medicine in the treatment of essential hypertension: a systematic review","authors":"Xiangmin Deng ,&nbsp;Qiuyun Xue ,&nbsp;Xianjie Feng ,&nbsp;Haoyu Wang ,&nbsp;Ping Luo ,&nbsp;Yaqi Tian ,&nbsp;Rui Zhang ,&nbsp;Gaochuan Zhang ,&nbsp;Dongmei Yan ,&nbsp;Xu Zhou","doi":"10.1016/j.hermed.2025.101010","DOIUrl":"10.1016/j.hermed.2025.101010","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to systematically review the efficacy and safety of <em>Pueraria lobata radix</em> (Chinese name: Ge Gen) prescriptions (GGPs) of traditional Chinese medicine in treating hypertension.</div></div><div><h3>Methods</h3><div>We searched seven databases for randomised controlled trials (RCTs) comparing GGPs plus antihypertensive drugs versus antihypertensive drugs alone for essential hypertension. Primary outcomes were changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP), while secondary outcomes included 24hSBP, 24hDBP, responses to antihypertensive treatment, control of hypertensive symptoms, blood glucose and lipid indicators, and incidence of adverse events.</div></div><div><h3>Results</h3><div>Thirty-one RCTs involving 2<!--> <!-->501 patients were included. Compared with antihypertensive drugs alone, GGP adjuvant therapy significantly reduced SBP (mmHg) (mean difference [MD] −10.70, 95% confidence interval [CI] −12.75 to −8.65), DBP (MD −6.78, 95% CI −8.51 to −5.05), and 24hSBP (MD −7.13, 95% CI −10.78 to −3.47), increased the response to antihypertensive treatment (risk ratio 1.21, 95% CI 1.13–1.30) and hypertensive symptom control, and improved levels of total and low-density lipoprotein cholesterol, triglycerides, and blood glucose indicators. However, GGPs had no significant impact on high-density lipoprotein cholesterol (HDL-C) or 24hDBP, although the trial sequential analysis suggested false negatives for these outcomes.</div></div><div><h3>Conclusion</h3><div>GGPs, when used as complementary therapy, may improve various parameters related to blood pressure, blood lipids, and blood glucose in patients with essential hypertension and show good safety. However, the impact of GGPs on 24hDBP, hypertensive symptoms, and HDL-C remains uncertain due to the limited quality of evidence.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101010"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicinal survey of antidiabetic plants used by six indigenous communities in Sarawak, Borneo","authors":"Keeren Sundara Rajoo ,&nbsp;Philip Lepun ,&nbsp;Beatrice Lyeja Anak Kayok ,&nbsp;Nurul Azwany Umayrah ,&nbsp;Nazariena Abdullah","doi":"10.1016/j.hermed.2025.101011","DOIUrl":"10.1016/j.hermed.2025.101011","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarawak, located in one of the planet's most ecologically diverse regions, hosts over 30 distinct sub-ethnic groups, each with its own set of cultural, linguistic, and lifestyle distinctions. This has fostered the development of numerous, unique ethnobotanical traditions. Thus, this study aimed to document the antidiabetic ethnomedicinal knowledge of six indigenous communities and to examine how their cultural practices and beliefs influenced their respective approaches to managing diabetes.</div></div><div><h3>Methods</h3><div>Fieldwork was carried out between 2021 and 2024, engaging 231 herbal medicine practitioners from six Sarawak indigenous groups: Kenyah (n = 24), Melanau Igan (n = 71), Kayan (n = 30), Iban (n = 81), Punan (n = 13), and Baketan (n = 12). Ethnobotanical information was gathered using face-to-face interviews through both unstructured and semi-structured methods.</div></div><div><h3>Results</h3><div>The study documented 34 plant species utilised for diabetes treatment across five of the six communities, with 127 total use-reports. <em>Annona muricata</em> emerged as the most frequently cited species, with 22 use-reports spanning four communities, followed by <em>Orthosiphon aristatus</em> with 14 use-reports from two communities. Substantial differences were noted in traditional knowledge transmission, with rates ranging from 25% in the Kenyah to 91.5% in the Melanau Igan. Plant knowledge similarity between communities ranged from 0% to 35.29%, the highest similarity observed between the Kenyah and Iban.</div></div><div><h3>Discussion/Conclusions</h3><div>This study documents the distribution and transmission of antidiabetic plant knowledge within Sarawak's indigenous populations, with significant variations in species utilisation and knowledge preservation across communities. The quantified differences in knowledge transmission rates and practitioner expertise indicate varying levels of traditional knowledge preservation among the studied groups.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"51 ","pages":"Article 101011"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}