Journal of Herbal Medicine最新文献

{"title":"Clinical outcomes of hospitalised COVID-19 Omicron patients treated with traditional Chinese Medicine: A Retrospective Studymedicine: a retrospective study of a large medical centre in Shanghai, China","authors":"Yafang Guo ,&nbsp;Hong Lu ,&nbsp;Jialin Zhu ,&nbsp;Jianjun Feng ,&nbsp;Yonggang Gu ,&nbsp;Li Ma ,&nbsp;Yunsheng Huang ,&nbsp;Chengxing Xu ,&nbsp;Xinge Feng ,&nbsp;Zhongqiu Wen ,&nbsp;Lili Gao ,&nbsp;Wujun Xiong ,&nbsp;Xuhui Bao ,&nbsp;Changming Zhang ,&nbsp;Yipeng Zeng","doi":"10.1016/j.hermed.2024.100971","DOIUrl":"10.1016/j.hermed.2024.100971","url":null,"abstract":"<div><h3>Introduction</h3><div>The efficacy of Chinese herbal medicine (CHM) in treating infection with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be investigated. This study aimed to assess the efficacy of CHM in COVID-19 Omicron patients.</div></div><div><h3>Methods</h3><div>Inpatients aged 18 years or older were divided into two groups based on their treatment: Western medicine group (WMG) and CHM group (CHMG). Demographic and COVID-19-related outcome data of the inpatients were collected. We analyzed negative conversion time, hospital stay, and clinical outcomes.</div></div><div><h3>Results</h3><div>The Asymptomatic Type: Negative conversion time significantly decreased in the CHMG compared with that in the WMG (3.0 [range: 2.0–7.0] days vs 5.0 [range: 3.0–9.0] days, <em>P</em> &lt; 0.01). The hospital stay of the CHMG significantly decreased compared with that of the WMG (6.0 [range: 3.0–11.0] days vs 9.0 [range: 6.0–13.0] days, <em>P</em> &lt; 0.01). The group was independently associated with negative conversion time (<em>P</em> &lt; 0.01). The Mild/Moderate type: Negative conversion time significantly decreased in the CHMG compared with the WMG (6.0 [range: 2.0–11.0] days vs 8.0 [range: 3.0–12.0] days, <em>P</em> &lt; 0.01). The hospital stay of the CHMG significantly decreased compared with that of the WMG (9.0 [range: 5.0–14.0] days vs 11.0 [range: 7.0–16.0] days, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>We found that the use of the JingYinGuBiao formula in Asymptomatic type patients and the JingYinQinHua formula in Mild/Moderate type patients is one of the most effective ways of treating SARS-CoV-2 Omicron infection because it could shorten negative conversion time and hospital stay.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100971"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress and modern application analysis of chemical constituents and pharmacological effects of volatile oils in acrid Chinese medicines","authors":"Xinwen Zhu ,&nbsp;Xue Geng ,&nbsp;Qi Gao ,&nbsp;Ping Wang ,&nbsp;Dianhua Shi ,&nbsp;Yuecheng Liu ,&nbsp;Qiang Zhang ,&nbsp;Yanpeng Dai ,&nbsp;Qian Zhou","doi":"10.1016/j.hermed.2024.100970","DOIUrl":"10.1016/j.hermed.2024.100970","url":null,"abstract":"<div><h3>Introduction</h3><div>This review aims to provide a systematic summary of the chemical constituents, pharmacological effects, traditional use, clinical applications and quality control of acrid Chinese medicines to provide a reference for in-depth research and product development of acrid Chinese medicinal volatile oils.</div></div><div><h3>Methods</h3><div>In this study, the database of CNKI, Web of Science and PubMed were used to search for information on acrid Chinese medicines using the name (Latin name) and ‘volatile oil’.</div></div><div><h3>Results</h3><div>This review summarises and analyzes the chemical composition and pharmacological effect of 126 kinds of eight types of acrid Chinese medicines. The results show that the main components of the volatile oils used in acrid Chinese medicines are terpenoids and terpenes, followed by alcohols and esters. These components have been used in medicine because of their pharmacological activities.</div></div><div><h3>Conclusions</h3><div>Volatile oils have a broad spectrum of pharmacological activities. However, due to the complex composition and unstable quality of volatile oils, the wider application of volatile oils is limited; the current quality specifications at all levels lack research on the composition limits and standards of volatile oils. Therefore, establishing corresponding quality control standards should be the key research direction for volatile oils in the future.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100970"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group B Strep During Pregnancy and Allium sativum L.","authors":"Kátia Andrea de Menezes Torres ,&nbsp;Sônia Maria Rolim Rosa Lima ,&nbsp;Maria Thereza Gamberini ,&nbsp;Domingos Sávio Rodrigues ,&nbsp;Pedro Ismael Silva Junior","doi":"10.1016/j.hermed.2024.100965","DOIUrl":"10.1016/j.hermed.2024.100965","url":null,"abstract":"<div><h3>Introduction</h3><div>Maternal colonisation with <em>Streptococcus agalactiae</em>, or Group B <em>Streptococcus</em> (<strong>GBS</strong>), during pregnancy increases the risk of neonatal infection through vertical transmission from the mother to the foetus, either before or during labour. This study aimed to evaluate the antimicrobial activity of the Sep-Pak 80% (<strong>SP80</strong>) fraction derived from <em>Allium sativum</em> L. and its synergistic potential with antibiotics against GBS strains.</div></div><div><h3>Methods</h3><div>Antimicrobial activity and potential synergism were assessed via broth microdilution and disk diffusion assays. Fifty-five clinical isolates and one American type culture collection (ATCC) strain of GBS were tested with the disk diffusion method to assess the combination of the SP80 fraction with ampicillin and penicillin G. A broth microdilution assay was performed on one ATCC strain.</div></div><div><h3>Results</h3><div>The minimum inhibitory concentrations of SP80, ampicillin, and penicillin G against <em>Streptococcus agalactiae</em> (ATCC 12386) were 5 mg/mL, 0.01 µg/mL, and 0.06 µg/mL, respectively. The combination of SP80 with antibiotics, assessed through broth microdilution, demonstrated an additive effect. Statistical analysis revealed that the mean inhibition zone for ampicillin, when combined with the SP80 fraction using the disk diffusion method, was greater than that for ampicillin alone, although the difference was not statistically significant. For penicillin G, the mean remained unchanged when it was combined with SP80. The inhibition zones of the isolated antibiotics revealed that the tested strains were more resistant to penicillin G than to ampicillin.</div></div><div><h3>Conclusions</h3><div>The SP80 fraction exhibits antimicrobial activity against GBS. When combined with antibiotics, it has an additive effect, suggesting that this approach could be promising for combating GBS infections.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100965"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of flaxseed oil on non-alcoholic fatty liver disease: a randomised controlled trial","authors":"Ali Beheshti Namdar ,&nbsp;Delaram Omidvar ,&nbsp;Forouzan Amerizadeh ,&nbsp;Mona Kabiri ,&nbsp;Hediyeh Beheshti Namdar ,&nbsp;Sahar Ravanshad","doi":"10.1016/j.hermed.2024.100967","DOIUrl":"10.1016/j.hermed.2024.100967","url":null,"abstract":"<div><h3>Introduction</h3><div>Non-Alcoholic Fatty Liver Disease (NAFLD) is a prevalent liver disorder and a leading cause of elevated liver enzymes. Previous research indicates that a diet rich in polyunsaturated fatty acids (PUFAs) can alleviate liver insulin resistance. This study investigates the therapeutic effects of flaxseed oil, a primary PUFA source, on NAFLD treatment.</div></div><div><h3>Methods</h3><div>In a randomized clinical trial comprising 60 NAFLD patients diagnosed with NAFLD of grades 1, 2, and 3, participants were assigned to either a flaxseed oil capsule or a placebo group, for a total duration of 2 months.</div></div><div><h3>Results</h3><div>Before the intervention, both groups showed no significant differences in examined parameters. However, after the intervention, the flaxseed oil group exhibited significant improvements in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), fasting blood sugar (FBS), and total bilirubin, compared to the placebo group. Specifically, reductions were observed in AST (<em>P</em> = 0.010), ALT (<em>P</em> = 0.047), ALP (<em>P</em> &lt; 0.001), FBS (<em>P</em> = 0.016), and total bilirubin (<em>P</em> = 0.004).</div></div><div><h3>Conclusions</h3><div>These findings suggest that flaxseed oil may hold promise as a therapeutic intervention for NAFLD, highlighting its potential in managing liver disease and metabolic parameters.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100967"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial","authors":"Vahirezad Lalezari ,&nbsp;Vajiheh Aghamollaii ,&nbsp;Ahmadreza Moslehi ,&nbsp;Amir Najafi ,&nbsp;Mohammadamin Parsaei ,&nbsp;Alireza Beikmarzehei ,&nbsp;Hossein Sanjari Moghaddam ,&nbsp;Amir Hossein Abdolghaffari ,&nbsp;Shahin Akhondzadeh","doi":"10.1016/j.hermed.2024.100968","DOIUrl":"10.1016/j.hermed.2024.100968","url":null,"abstract":"<div><h3>Aim</h3><div>Evidence has highlighted neuroprotective effects of saffron in animal models of Parkinson’s disease (PD). The present study investigated the efficacy and safety of add-on saffron on motor and depressive symptoms of patients with PD.</div></div><div><h3>Methods</h3><div>This study was an 8-week, randomized, double-blind, and parallel-group clinical trial. Known cases of PD with depression were randomized to receive either a routine treatment (levodopa or levodopa-equivalent dose of a dopamine agonist) plus saffron capsule (15 mg bid) or routine treatment plus placebo. All participants were assessed using the Hamilton Depression Rating Scale (HAMD), Geriatric Depression Scale-30 (GDS-30), item 3 of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 1, MDS-UPDRS part 3, and H and Y scale at baseline and at week 8.</div></div><div><h3>Results</h3><div>A total of 52 patients (25 in saffron and 27 in placebo groups) were included. Our results demonstrated that saffron could not improve motor symptoms of PD patients (F=0.53, df=1, p=0.424). However, repeated-measures analysis showed a significant effect of time <span><math><mo>×</mo></math></span> treatment (F=8.24, df=1, p=0.006) on HAMD scores, indicating a greater improvement of depressive symptoms in saffron compared to placebo groups. Our study showed nonsignificant findings regarding the secondary outcome measures (GDS-30, item 3 of MDS-UPDRS part 1, and H and Y scale). We showed that treatment with saffron is safe in PD.</div></div><div><h3>Conclusion</h3><div>We substantiated that add-on treatment with saffron significantly improved depression, but not motor symptoms, in PD. Further trials with larger sample sizes and longer follow-ups are needed to confirm our findings.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100968"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial","authors":"Nahid Nazari ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Hassan Rakhshandeh ,&nbsp;Seyed Reza Mazloom ,&nbsp;Ramin Azarhoush","doi":"10.1016/j.hermed.2024.100964","DOIUrl":"10.1016/j.hermed.2024.100964","url":null,"abstract":"<div><h3>Introduction</h3><div>Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.</div></div><div><h3>Methods</h3><div>In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.</div></div><div><h3>Results</h3><div>Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P&lt;0.001).</div></div><div><h3>Conclusions</h3><div>After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100964"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical examination of Cistus laurifolius extract and its impact on cytotoxicity, apoptosis and oxidative stress in colorectal and breast cancer cell lines","authors":"Fatma Yildiz ,&nbsp;Hamiyet Eciroglu Sarban ,&nbsp;Fatma Gonca Kocanci ,&nbsp;Meltem Gungor ,&nbsp;Ersin Yucel ,&nbsp;Dilge Yucel","doi":"10.1016/j.hermed.2024.100966","DOIUrl":"10.1016/j.hermed.2024.100966","url":null,"abstract":"<div><h3>Introduction</h3><div>Colon and breast cancer are the most common types of cancer worldwide. This study investigate<del>s</del>d the anticancer properties of <em>Cistus laurifolius</em> L. leaf extract on breast cancer (MCF-7) and human colon cancer (Caco-2) cell lines.</div></div><div><h3>Methods</h3><div>The research involved meticulous collection, drying and processing of <em>C. laurifolius</em> leaves to extract bioactive compounds, subsequently analyzed for phenolic content using advanced LC-MS/MS technology. Cell viability of the extract on MCF-7 and Caco-2 cells was demonstrated by MTT test. Levels of critical apoptotic markers (Bad, Bax/Bcl-2, Bax/Bcl-xl, Caspase-9) and Total Antioxidant Capacity (TAC) and Total Oxidant Capacity (TOC), which affect the antioxidant system, were evaluated by the ELISA method. Identification of phenolic compounds, including quercetin and rutin, through target prediction analysis enriches our understanding of bioactive molecules.</div></div><div><h3>Results</h3><div>The results of the study showed that <em>C. laurifolius</em> extract inhibited cell proliferation time and dose-dependent on Caco-2 and MCF-7 cells (P&lt;0.05). TAC, Bax/Bcl-2 and Bax/Bcl-xl ratios in MCF-7 and Caco-2 cells increased in a dose-dependent manner compared to the control group. In MCF-7 cells, TAC (p&lt;0.05; p&lt;0.01), Bax/Bcl-2 (p&lt;0.001; p&lt;0.0001) and Bax-Bcl-xl (p&lt;0.01) ratios increased at 24 h compared to the control group. In Caco-2 cells, TAC (p&lt;0.001), Bax/Bcl-2 ratios increased at 48 h (p&lt;0.05), while Bax-Bcl-xl ratios decreased (p&lt;0.01; p&lt;0.001) compared to the control group.</div></div><div><h3>Conclusion</h3><div><em>C. laurifolius</em> leaf extracts emerge as a promising anticancer candidate, hindering cell proliferation and inducing apoptosis in colon and breast cancer cells. The classification of bioactive molecules may facilitate further clinical therapeutic interventions targeting colon and breast cancer.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100966"},"PeriodicalIF":2.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jing-Si herbal tea attenuates oral cancer cell viability, migration, and invasion by regulating epithelial-to-mesenchymal transition and reactive oxygen species accumulation","authors":"Po-Chih Hsu ,&nbsp;Chia-Chen Hsu ,&nbsp;Yi-Jan Hsia ,&nbsp;Chan-Yen Kuo","doi":"10.1016/j.hermed.2024.100969","DOIUrl":"10.1016/j.hermed.2024.100969","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral cancer is the sixth most common cancer worldwide and can be life-threatening if not diagnosed and treated in its early stages. Jing-Si herbal tea (JSHT), containing eight traditional Chinese medicine-based herbs, is known to suppress the malignancy, growth, and metastasis of several tumour cells, including breast, lung, and colon cancer cells. However, the pharmacological effect of JSHT on oral cancer progression is still unclear.</div></div><div><h3>Methods</h3><div>In this study, we evaluated the potential of JSHT to arrest the development of oral cancer via induction of cell death by reactive oxygen species (ROS) accumulation and inhibition of migration, invasion, and epithelial-to-mesenchymal transition (EMT). For this purpose, we employed the human tongue squamous cell carcinoma human tongue squamous carcinoma cell line, which we treated with different JSHT concentrations for 24 hours, and assessed cell viability, migration, and wound healing capabilities, together with western blotting for measuring expression levels of EMT markers.</div></div><div><h3>Results</h3><div>Survival, migration/invasion ability, EMT, and ROS production in the human tongue squamous carcinoma human tongue squamous carcinoma and FaDu human pharynx squamous cell carcinoma cell line were decreased by JSHT treatment via Lon protease-independent mechanisms.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that JSHT could be regarded as a candidate new supplement to existing anticancer therapies and an alternative, orally administered healthcare product for treating oral squamous cell carcinoma.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100969"},"PeriodicalIF":2.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional use of medicinal plants in Brazil to treat mycosis, antifungal activity, and their nanomaterials against Trichophyton rubrum","authors":"José Jailson Lima Bezerra ,&nbsp;Viviane Bezerra da Silva ,&nbsp;Douglas Dourado","doi":"10.1016/j.hermed.2024.100961","DOIUrl":"10.1016/j.hermed.2024.100961","url":null,"abstract":"<div><h3>Introduction</h3><div>Mycosis are health problems that affects the global population. Current treatments have used synthetic drugs with several side effects. To overcome these drawbacks, medicinal plants have been investigated as a promising alternative to this problem, and these can be associated with nanotechnology. Thus, this study brought together, for the first time, information from the literature on the traditional use of plants to treat mycosis in Brazil, antifungal potential against <em>Trichophyton rubrum</em>, phytochemistry, nanomaterials, and toxicity.</div></div><div><h3>Methods</h3><div>We reviewed the literature since the first report in 2002 on the traditional use of medicinal plants to treat mycosis in Brazil until May 2024.</div></div><div><h3>Results</h3><div>According to the scientific documents analyzed, traditional communities in Brazil use 87 plant species distributed in 43 families to treat mycosis. Among these 87 species, only 29 have been evaluated for <em>in vitro</em> antifungal efficacy against <em>T. rubrum</em>. Citral, ethyl cinnamate, eugenol, linalool, thymol, and ricinine isolated from Brazilian medicinal plants were effective against this dermatophyte. Furthermore, we noted that seven species were associated with nanomaterials (nine nanoparticles and one nanoemulsion).</div></div><div><h3>Conclusion</h3><div>The development of new antifungals to treat onychomycosis caused by <em>T. rubrum</em> based on medicinal plants should be explored since these phytochemicals show advantages over synthetic treatments. Moreover, when associated with nanotechnological strategies, these natural products can have improved physicochemical and biological properties, proving to be promising tools against onychomycosis.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100961"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Herbal Bath for Eczema: A Systematic Review and Meta-analysis of 39 Randomised Controlled Trials","authors":"Yiran Chen ,&nbsp;Xiaoxuan Ma ,&nbsp;Xiaoya Fei ,&nbsp;Ying Luo ,&nbsp;Yue Luo ,&nbsp;Xin Ma ,&nbsp;Le Kuai ,&nbsp;Bin Li ,&nbsp;Bin Fan ,&nbsp;Xiaojie Ding","doi":"10.1016/j.hermed.2024.100959","DOIUrl":"10.1016/j.hermed.2024.100959","url":null,"abstract":"<div><h3>Introduction</h3><div>Chinese herbal bath (<strong>CHB</strong>) shows promise in treating eczema, but high-grade clinical evidence is lacking. This review aims to systematically evaluate the efficacy and safety of CHB in the treatment of eczema.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, VIP Chinese Journal Service Platform, and Wan Fang Database were searched for Randomised controlled trials comparing CHB with non-CHB interventions for eczema. RevMan5.4 software was used to calculate the 95% confidence interval (<strong>CI</strong>) risk ratio (<strong>RR</strong>) and perform meta-analysis.</div></div><div><h3>Results</h3><div>Our meta-analysis incorporated data from 39 randomised controlled trials, demonstrating CHB's enhanced efficacy over conventional therapy (RR, 1.15; 95% CI, 1.11–1.20; <em>P</em> &lt; 0.00001) and improved outcomes when used in conjunction with conventional therapy (RR, 1.14; 95% CI, 1.09–1.19; <em>P</em> &lt; 0.00001). Significant improvements were observed in Eczema Area Severity Index scores (mean difference [MD], −1.04; 95% CI, −1.50 to −0.59; <em>P</em> &lt; 0.00001), visual analogue scale scores (MD, −0.61; 95% CI, −0.64 to −0.58; <em>P</em> &lt; 0.00001), and Dermatology Life Quality Index scores (MD, −1.15; 95% CI, −1.68 to −0.61; <em>P</em> &lt; 0.00001), alongside a lower recurrence rate (RR, 0.24; 95% CI, 0.14–0.41; <em>P</em> &lt; 0.00001) without an increased risk of adverse events. Additionally, immunological marker analysis revealed significant modulatory effects on the immune response.</div></div><div><h3>Conclusions</h3><div>Chinese herbal bath represents a safe and effective alternative for eczema treatment, offering significant clinical improvements and potential immunological benefits. Future research should focus on larger, high-quality randomised controlled trials and detailed biochemical analyses of CHB formulations to further validate these findings and explore the mechanisms of action.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100959"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}