Journal of Herbal Medicine最新文献

{"title":"Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial","authors":"Vahirezad Lalezari ,&nbsp;Vajiheh Aghamollaii ,&nbsp;Ahmadreza Moslehi ,&nbsp;Amir Najafi ,&nbsp;Mohammadamin Parsaei ,&nbsp;Alireza Beikmarzehei ,&nbsp;Hossein Sanjari Moghaddam ,&nbsp;Amir Hossein Abdolghaffari ,&nbsp;Shahin Akhondzadeh","doi":"10.1016/j.hermed.2024.100968","DOIUrl":"10.1016/j.hermed.2024.100968","url":null,"abstract":"<div><h3>Aim</h3><div>Evidence has highlighted neuroprotective effects of saffron in animal models of Parkinson’s disease (PD). The present study investigated the efficacy and safety of add-on saffron on motor and depressive symptoms of patients with PD.</div></div><div><h3>Methods</h3><div>This study was an 8-week, randomized, double-blind, and parallel-group clinical trial. Known cases of PD with depression were randomized to receive either a routine treatment (levodopa or levodopa-equivalent dose of a dopamine agonist) plus saffron capsule (15 mg bid) or routine treatment plus placebo. All participants were assessed using the Hamilton Depression Rating Scale (HAMD), Geriatric Depression Scale-30 (GDS-30), item 3 of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 1, MDS-UPDRS part 3, and H and Y scale at baseline and at week 8.</div></div><div><h3>Results</h3><div>A total of 52 patients (25 in saffron and 27 in placebo groups) were included. Our results demonstrated that saffron could not improve motor symptoms of PD patients (F=0.53, df=1, p=0.424). However, repeated-measures analysis showed a significant effect of time <span><math><mo>×</mo></math></span> treatment (F=8.24, df=1, p=0.006) on HAMD scores, indicating a greater improvement of depressive symptoms in saffron compared to placebo groups. Our study showed nonsignificant findings regarding the secondary outcome measures (GDS-30, item 3 of MDS-UPDRS part 1, and H and Y scale). We showed that treatment with saffron is safe in PD.</div></div><div><h3>Conclusion</h3><div>We substantiated that add-on treatment with saffron significantly improved depression, but not motor symptoms, in PD. Further trials with larger sample sizes and longer follow-ups are needed to confirm our findings.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial","authors":"Nahid Nazari ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Hassan Rakhshandeh ,&nbsp;Seyed Reza Mazloom ,&nbsp;Ramin Azarhoush","doi":"10.1016/j.hermed.2024.100964","DOIUrl":"10.1016/j.hermed.2024.100964","url":null,"abstract":"<div><h3>Introduction</h3><div>Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.</div></div><div><h3>Methods</h3><div>In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.</div></div><div><h3>Results</h3><div>Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P&lt;0.001).</div></div><div><h3>Conclusions</h3><div>After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical examination of Cistus laurifolius extract and its impact on cytotoxicity, apoptosis and oxidative stress in colorectal and breast cancer cell lines","authors":"Fatma Yildiz ,&nbsp;Hamiyet Eciroglu Sarban ,&nbsp;Fatma Gonca Kocanci ,&nbsp;Meltem Gungor ,&nbsp;Ersin Yucel ,&nbsp;Dilge Yucel","doi":"10.1016/j.hermed.2024.100966","DOIUrl":"10.1016/j.hermed.2024.100966","url":null,"abstract":"<div><h3>Introduction</h3><div>Colon and breast cancer are the most common types of cancer worldwide. This study investigate<del>s</del>d the anticancer properties of <em>Cistus laurifolius</em> L. leaf extract on breast cancer (MCF-7) and human colon cancer (Caco-2) cell lines.</div></div><div><h3>Methods</h3><div>The research involved meticulous collection, drying and processing of <em>C. laurifolius</em> leaves to extract bioactive compounds, subsequently analyzed for phenolic content using advanced LC-MS/MS technology. Cell viability of the extract on MCF-7 and Caco-2 cells was demonstrated by MTT test. Levels of critical apoptotic markers (Bad, Bax/Bcl-2, Bax/Bcl-xl, Caspase-9) and Total Antioxidant Capacity (TAC) and Total Oxidant Capacity (TOC), which affect the antioxidant system, were evaluated by the ELISA method. Identification of phenolic compounds, including quercetin and rutin, through target prediction analysis enriches our understanding of bioactive molecules.</div></div><div><h3>Results</h3><div>The results of the study showed that <em>C. laurifolius</em> extract inhibited cell proliferation time and dose-dependent on Caco-2 and MCF-7 cells (P&lt;0.05). TAC, Bax/Bcl-2 and Bax/Bcl-xl ratios in MCF-7 and Caco-2 cells increased in a dose-dependent manner compared to the control group. In MCF-7 cells, TAC (p&lt;0.05; p&lt;0.01), Bax/Bcl-2 (p&lt;0.001; p&lt;0.0001) and Bax-Bcl-xl (p&lt;0.01) ratios increased at 24 h compared to the control group. In Caco-2 cells, TAC (p&lt;0.001), Bax/Bcl-2 ratios increased at 48 h (p&lt;0.05), while Bax-Bcl-xl ratios decreased (p&lt;0.01; p&lt;0.001) compared to the control group.</div></div><div><h3>Conclusion</h3><div><em>C. laurifolius</em> leaf extracts emerge as a promising anticancer candidate, hindering cell proliferation and inducing apoptosis in colon and breast cancer cells. The classification of bioactive molecules may facilitate further clinical therapeutic interventions targeting colon and breast cancer.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional use of medicinal plants in Brazil to treat mycosis, antifungal activity, and their nanomaterials against Trichophyton rubrum","authors":"José Jailson Lima Bezerra ,&nbsp;Viviane Bezerra da Silva ,&nbsp;Douglas Dourado","doi":"10.1016/j.hermed.2024.100961","DOIUrl":"10.1016/j.hermed.2024.100961","url":null,"abstract":"<div><h3>Introduction</h3><div>Mycosis are health problems that affects the global population. Current treatments have used synthetic drugs with several side effects. To overcome these drawbacks, medicinal plants have been investigated as a promising alternative to this problem, and these can be associated with nanotechnology. Thus, this study brought together, for the first time, information from the literature on the traditional use of plants to treat mycosis in Brazil, antifungal potential against <em>Trichophyton rubrum</em>, phytochemistry, nanomaterials, and toxicity.</div></div><div><h3>Methods</h3><div>We reviewed the literature since the first report in 2002 on the traditional use of medicinal plants to treat mycosis in Brazil until May 2024.</div></div><div><h3>Results</h3><div>According to the scientific documents analyzed, traditional communities in Brazil use 87 plant species distributed in 43 families to treat mycosis. Among these 87 species, only 29 have been evaluated for <em>in vitro</em> antifungal efficacy against <em>T. rubrum</em>. Citral, ethyl cinnamate, eugenol, linalool, thymol, and ricinine isolated from Brazilian medicinal plants were effective against this dermatophyte. Furthermore, we noted that seven species were associated with nanomaterials (nine nanoparticles and one nanoemulsion).</div></div><div><h3>Conclusion</h3><div>The development of new antifungals to treat onychomycosis caused by <em>T. rubrum</em> based on medicinal plants should be explored since these phytochemicals show advantages over synthetic treatments. Moreover, when associated with nanotechnological strategies, these natural products can have improved physicochemical and biological properties, proving to be promising tools against onychomycosis.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Herbal Bath for Eczema: A Systematic Review and Meta-analysis of 39 Randomised Controlled Trials","authors":"Yiran Chen ,&nbsp;Xiaoxuan Ma ,&nbsp;Xiaoya Fei ,&nbsp;Ying Luo ,&nbsp;Yue Luo ,&nbsp;Xin Ma ,&nbsp;Le Kuai ,&nbsp;Bin Li ,&nbsp;Bin Fan ,&nbsp;Xiaojie Ding","doi":"10.1016/j.hermed.2024.100959","DOIUrl":"10.1016/j.hermed.2024.100959","url":null,"abstract":"<div><h3>Introduction</h3><div>Chinese herbal bath (<strong>CHB</strong>) shows promise in treating eczema, but high-grade clinical evidence is lacking. This review aims to systematically evaluate the efficacy and safety of CHB in the treatment of eczema.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, VIP Chinese Journal Service Platform, and Wan Fang Database were searched for Randomised controlled trials comparing CHB with non-CHB interventions for eczema. RevMan5.4 software was used to calculate the 95% confidence interval (<strong>CI</strong>) risk ratio (<strong>RR</strong>) and perform meta-analysis.</div></div><div><h3>Results</h3><div>Our meta-analysis incorporated data from 39 randomised controlled trials, demonstrating CHB's enhanced efficacy over conventional therapy (RR, 1.15; 95% CI, 1.11–1.20; <em>P</em> &lt; 0.00001) and improved outcomes when used in conjunction with conventional therapy (RR, 1.14; 95% CI, 1.09–1.19; <em>P</em> &lt; 0.00001). Significant improvements were observed in Eczema Area Severity Index scores (mean difference [MD], −1.04; 95% CI, −1.50 to −0.59; <em>P</em> &lt; 0.00001), visual analogue scale scores (MD, −0.61; 95% CI, −0.64 to −0.58; <em>P</em> &lt; 0.00001), and Dermatology Life Quality Index scores (MD, −1.15; 95% CI, −1.68 to −0.61; <em>P</em> &lt; 0.00001), alongside a lower recurrence rate (RR, 0.24; 95% CI, 0.14–0.41; <em>P</em> &lt; 0.00001) without an increased risk of adverse events. Additionally, immunological marker analysis revealed significant modulatory effects on the immune response.</div></div><div><h3>Conclusions</h3><div>Chinese herbal bath represents a safe and effective alternative for eczema treatment, offering significant clinical improvements and potential immunological benefits. Future research should focus on larger, high-quality randomised controlled trials and detailed biochemical analyses of CHB formulations to further validate these findings and explore the mechanisms of action.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of ginger in reducing post-spinal puncture shivering in cesarean section patients: a randomised clinical trial","authors":"Banafsheh Mashak ,&nbsp;Zahra Ataie ,&nbsp;Fatemeh Bayat ,&nbsp;Masomeh Farahani ,&nbsp;Niloofar Khoshnam Rad ,&nbsp;Mansoureh Yazdkhasti","doi":"10.1016/j.hermed.2024.100962","DOIUrl":"10.1016/j.hermed.2024.100962","url":null,"abstract":"<div><h3>Introduction</h3><div>Postoperative shivering is a common and unpleasant complication of spinal puncture. Various pharmacologic and non-pharmacologic options have been studied to control shivering. This study aimed to evaluate the effectiveness of ginger in treating post-spinal puncture shivering in patients undergoing cesarean section.</div></div><div><h3>Methods</h3><div>A placebo-controlled, single-blinded, randomised controlled trial was conducted. A total of 242 eligible participants were assigned to the ginger or placebo suppository groups using block randomisation. Suppositories were administered immediately after the operation. The shivering scores were recorded for both groups at six time points (20, 35, 50, 65, 80, and 95 minutes) after the intervention. The participants' shivering scores were analysed using a repeated-measures analysis of variance (ANOVA) test.</div></div><div><h3>Results</h3><div>The results showed significant differences between the two groups in the mean shivering scores at 20, 35, 50, 65, and 80 minutes (<em>P</em> &lt; 0.05), with no significant difference at 90 minutes. The trend of changes at six time points demonstrated that shivering intensity significantly differed between the two groups over time (<em>P</em> &lt; 0.001). No significant side effects were observed in patients in the two groups.</div></div><div><h3>Conclusion</h3><div>Ginger suppository reduces shivering after spinal puncture in patients undergoing cesarean section (CS). Due to the lack of side effects and lower cost of ginger suppositories, it can be considered as an option for post-CS shivering.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pomegranate versus chlorhexidine mouthwash or gel on periodontal disease: a systematic review and meta-analysis","authors":"Roghayeh Javan ,&nbsp;Zahra Baghani ,&nbsp;Elaheh Foroumandi","doi":"10.1016/j.hermed.2024.100955","DOIUrl":"10.1016/j.hermed.2024.100955","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of current systematic review and meta-analysis study was to evaluate the effect of pomegranate (POM) versus Chlorhexidine (CHX) mouthwashes or gels on periodontal disease.</div></div><div><h3>Methods</h3><div>An electronic search on PubMed, Scopus, Science direct, and Cochrane, as well as manual search was conducted on the studies that were published up until August 2023. Randomised controlled trials studies that had examined the effect of POM versus CHX mouthwash or gel on plaque (PI), gingival (GI), and bleeding (BI) indices after 7 and 14–15 days follow up with 95% confidence interval (CI) were pooled. To assess the heterogeneity of the findings, the I² test was applied and also publication bias was evaluated by visual examination of the funnel plot symmetry.</div></div><div><h3>Results</h3><div>Seven studies with 330 participants were analyzed. The meta-analysis showed that there was a significant difference between the effects of CHX intervention on PI compared to POM intervention, when the duration of intervention was 14–15 days (standard mean differences [SMD]: −2.25; 95% CI: −4.18 to −0.32, <em>P</em> <!-->=<!--> <!-->0.02). There was not any significant difference among the effects of CHX and POM intervention on PI when the study duration was up to 7 days. Further, there was not seen any significant differences between the effects of POM and CHX on BI or GI of the subjects.</div></div><div><h3>Conclusion</h3><div>The findings indicated that POM mouthwashes or gel were effective in reducing PI, BI, and GI in patients with periodontal disease. Therefore, it can be suggested as a suitable alternative of CHX for inflammation control.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical composition and anti-oxidant, anti-Alzheimer and anti-inflammatory activities of pomegranate fruit as function of variety and ripening","authors":"Jalila Bekir,&nbsp;Mohamed Mars","doi":"10.1016/j.hermed.2024.100960","DOIUrl":"10.1016/j.hermed.2024.100960","url":null,"abstract":"<div><h3>Introduction</h3><div>Medicinal plants are considered as rich resources of secondary metabolites and have been used for treating diseases. Pomegranate (<em>Punica granatum</em>) is considered ‘a pharmacy unto itself’. The current study aimed to evaluate the effect of ripening and variety factors on the antioxidant activity of pomegranate fruits and their capacity to inhibit three enzymes involved in degenerative diseases.</div></div><div><h3>Methods</h3><div>The fruits were collected from four Tunisian pomegranate varieties (Espagnoule, Rafrafi, Zaghwani and Zehri) during three maturity stages. Phytochemical content, the antioxidant activity by DPPH and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays and acetylcholinesterase, butyrylcholinesterase and 15-lipoxygenase inhibition activities were carried out.</div></div><div><h3>Results</h3><div>The unripe fruits were found to be the richest in terms of total phenolic content. Total flavonoids, tannins, anthocyanins and acetylcholinesterase, butyrylcholinesterase and 15-lipoxygenase inhibition activities varied greatly during ripening process and within varieties. It was found that unripe fruits of Zehri (IC₅₀ = 2.2 µg/ml by 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay) and Rafrafi (IC₅₀ = 73.4 µg/ml by 2, 2-diphenyl-l-picrylhydrazyl assay) varieties exhibited the highest antioxidant capacities. The strongest extract against acetylcholinesterase and butyrylcholinesterase was found to be the unripe fruit extract of Espagnoule variety with IC₅₀ values of 86.7 and 58.0 µg/ml, respectively. The ethanolic extract from the unripe fruit of Zehri pomegranate variety inhibited moderately 15-lipoxygenase activity with an IC₅₀ value of 63.0 µg/ml.</div></div><div><h3>Conclusion</h3><div>The current study supported the popular use of pomegranate fruits, and highlighted also the potential effect of variety and ripening factors on their chemical composition and <em>in vitro</em> biological activities.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of a Chinese herb in nonoperative bone fractures in Taiwan: a retrospective multi-central database cohort study","authors":"Chung-Yuan Hsu ,&nbsp;Shin-Yu Huang ,&nbsp;Wei-Jen Cheng","doi":"10.1016/j.hermed.2024.100956","DOIUrl":"10.1016/j.hermed.2024.100956","url":null,"abstract":"<div><h3>Introduction</h3><div>Bone fracture is a critical issue worldwide, affecting daily activities and increasing living expenses. The effect of Chinese herbs on bone union has been evaluated in recent years. However, its clinical efficacy in the unionisation of bone fractures is not completely elucidated. Zheng-Gu-Zi-Jin-Dang (ZGZJD) is a famous formula in Chinese medicine traumatology that has been widely used in patients with fractures in previous studies.</div></div><div><h3>Methods</h3><div>We used the Chang Gung Research Database and retrospectively reviewed patients at Chang Gung Memorial Hospital who suffered from bone fractures to evaluate the efficacy of ZGZJD intervention on bone union within 3 months after bone fractures and we used the frequency matching method in a 1:5 ratio for further analysis.</div></div><div><h3>Results</h3><div>Between 2004 and 2016, 291<!--> <!-->851 fractures were diagnosed at Chang Gung Memorial Hospital. A total of 544 patients received ZGZJD, and 2<!--> <!-->720 patients were match as control which do not use the herbs. However, we adjusted the comorbidities affecting the bone union, sex, age and different body extremities and there were no better healing rate in ZGZJD patient.</div></div><div><h3>Conclusions</h3><div>Although ZGZJD is a common formula used in bone fractures, there is no direct clinical evidence that it enhances bone union. However, according to ingredients analysis in ZGZJD, this famous Chinese traumatology medicine may be useful during the inflammatory phase of bone healing.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the holistic value of Danhong injection for chronic stable angina: a multi-criteria decision analysis in China","authors":"Pengli Su ,&nbsp;Kai Zhi ,&nbsp;Haixia Dang ,&nbsp;Huanhuan Xu ,&nbsp;Jing Xiao ,&nbsp;Jun Liu ,&nbsp;Zhong Wang ,&nbsp;Yanan Yu","doi":"10.1016/j.hermed.2024.100957","DOIUrl":"10.1016/j.hermed.2024.100957","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to assess the holistic value of Danhong injection (DHI) for treating chronic stable angina (CSA) and to identify the therapeutic characteristics of DHI.</div></div><div><h3>Methods</h3><div>The holistic value of DHI was assessed using a well-established evaluation index system including 34 criteria based on the Multi-criteria decision analysis (MCDA) model. Each criterion was rated by seven experts based on an evidence matrix comprising a literature review on DHI for treating CSA. The overall value of DHI for the treatment of CSA was evaluated by aggregating these performance scores and predetermined weights. Additionally, the contributions of each domain and criterion to the overall value estimate were calculated. Uncertainty was explored using an online retest and intra-rater correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>We found that the comprehensive value estimate of DHI for treating CSA was 80.18 points. The domain of “safety and risk management” was the strongest contributor to the final estimated value (30.37), followed by “effectiveness” (23.75). The criteria “size of population affected by disease” (3.79), “risk control of toxic medicinal materials” (4.38), “comparative non-medical costs” (1.14), “clarity of the mechanism of drug action” (0.6), “sustainability of medicinal materials resources” (1.91) and “patient compliance” (4.59) were found to be the most significant contributors to the overall value estimate across the 6 evaluation domains. The initial scores for DHI over the two rounds showed good consistency across panelists (ICC<!--> <!-->=<!--> <!-->0.886 [0.858–0.909]).</div></div><div><h3>Conclusion</h3><div>Compared with standard treatment alone, DHI was perceived as being at a “good level” intervention.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}