Essential oil of Cleome coluteoides (Boiss.): phytochemical constituents, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, enzymatic inhibition, and xanthine oxidase inhibitory properties

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-06-09 DOI:10.1016/j.hermed.2025.101036

Majid Sharifi-Rad , Jibanjyoti Panda , Yugal Kishore Mohanta , Pawel Pohl , Gokhan Zengin , Mark G. Moloney

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引用次数: 0

Abstract

Introduction

Plant based natural products are well known for their therapeutic potential as they are used to treat many diseases, but these plants need to be validated through the scientific study. Therefore, the present investigation was carried out to evaluate the usefulness of the bioactive compounds present in the essential oils of the Cleome coluteoides.

Methods

Different parts of the plant, including leaves, flowers, fruits, stems and roots, were used to extract the essential oils. The chemical composition of essential oils was analysed by gas-chromatography mass spectrometry (GC-MS). Their antimicrobial properties were evaluated against several human pathogens (three fungi and four bacteria). The enzyme inhibition activity (α-amylase, tyrosinase, butyrylcholinesterase, acetylcholinesterase inhibitory tests) of the essential oils was evaluated, along with, their antioxidant activity (DPPH, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) tests), xanthine oxidase inhibitory activity, antiproliferative activity (against MCF-7 and Hep-G2), anti-arthritic activity (protein denature assay), and anti-inflammatory activity.

Results

Phytol, sclareol, 7-α-hydroxy manool, and piperitone were found to be the main compounds of the studied essential oils. Notable antibacterial, antifungal, enzyme inhibition, antioxidant, xanthine oxidase inhibitory, antiproliferative, anti-arthritic, and inflammatory activities were found form the essential oils. The best activity was found in the case of the essential oils made from leaves.

Discussion/Conclusions

These potential biological activities along with the chemical constitutes present in the essential oils of C. coluteoides can make them potentially utilisable in different biomedical and therapeutic applications in the future. Additionally, the studied plant and their essential oils can serve as a natural remedy for a variety of lifestyle diseases.

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丁香精油（Boiss.）：植物化学成分，抗氧化，抗菌，抗增殖，抗炎，酶抑制和黄嘌呤氧化酶抑制特性

基于植物的天然产物以其治疗潜力而闻名，因为它们被用于治疗许多疾病，但这些植物需要通过科学研究来验证。因此，本研究是为了评价其精油中存在的生物活性化合物的有效性。方法采用叶、花、果、茎、根等不同部位提取挥发油。采用气相色谱-质谱法（GC-MS）分析了精油的化学成分。它们对几种人类病原体（三种真菌和四种细菌）的抗菌性能进行了评估。评估了精油的酶抑制活性（α-淀粉酶、酪氨酸酶、丁基胆碱酯酶、乙酰胆碱酯酶抑制试验），以及抗氧化活性（DPPH、2,2'-氮化-二（3-乙基苯并噻唑啉-6-磺酸）试验）、黄嘌呤氧化酶抑制活性、抗增殖活性（抗MCF-7和Hep-G2）、抗关节炎活性（蛋白质变性试验）和抗炎活性。结果所研究精油的主要成分为叶醇、香核醇、7-α-羟基醇和胡椒酮。该精油具有显著的抗菌、抗真菌、酶抑制、抗氧化、黄嘌呤氧化酶抑制、抗增殖、抗关节炎和炎症活性。从树叶中提取的精油的活性最高。讨论/结论这些潜在的生物活性及其所含的化学成分使其在未来的生物医学和治疗领域具有潜在的应用价值。此外，所研究的植物及其精油可以作为各种生活方式疾病的自然疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.