Comparative evaluation of the clinical efficacy of triple therapy and the addition use of TCM in treating Helicobacter pylori-associated gastritis

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-06-02 DOI:10.1016/j.hermed.2025.101034

Mengli Xiao , Liying Zhang , Beihua Zhang , Liqun Bian , Zhenhua Li , Junxiang Li , Wei Wei , Min Liu , Li Liu , Chuijie Wang , Shaohong Shi , Jinkang Xu , Sheng Xie , Hong Shen , Qiang Yang , Guangjun Yan , Mingqi Wen , Fang Lu , Xudong Tang

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引用次数: 0

Abstract

Introduction

Traditional Chinese Medicine (TCM) has been found to be effective in the treatment of Helicobacter pylori (H. pylori). However, the quality of evidence is limited and there are few studies on TCM of H. pylori. This trials aimed to examine whether additional use of TCM can lead to better efficacy in the eradication rate of H. pylori.

Methods

This study consisted of a multicenter randomized controlled trial and a nonrandomized cohort. Subjects from TCM hospitals were allocated to a treatment group that received triple therapy or a combination group that received triple therapy combined with 2 weeks of herbal bulk or 2 weeks of herbal soup or 4 weeks of herbal soup. Patients in western hospitals received triple therapy (non-randomized control group). The eradication rate of H. pylori, the recurrence rate, the TCM symptom score, the patient-reported outcome scale (PRO), and safety indicators were observed and compared.

Results

960 patients screened, 768 were randomly assigned to the randomized treatment group, and 192 were assigned to the non-randomized group. No difference in the H. pylori eradication rate between the combination group compared with triple therapy (P > 0.05). Significant improvements were observed in TCM symptom scores, the quality of life in the combination group (P < 0.05). Moreover, it had a lower incidence of adverse reactions and rates of H. pylori recurrence (P < 0.05).

Conclusion

The additional use of TCM in triple therapy improves the quality of life, reduces adverse effects, and recurrence rates.

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三联疗法与中药加用治疗幽门螺杆菌相关性胃炎的临床疗效比较

中药（TCM）已被发现对治疗幽门螺杆菌（H. pylori）有效。然而，证据质量有限，关于幽门螺杆菌的中医研究很少。本试验旨在检验额外使用中药是否能提高幽门螺杆菌的根除率。方法本研究由多中心随机对照试验和非随机队列组成。将来自中医院的受试者分为三联治疗组和联合治疗组，分别采用三联治疗加2周药汤或2周药汤或4周药汤治疗。西方医院患者采用三联疗法（非随机对照组）。观察并比较两组幽门螺杆菌根除率、复发率、中医症状评分、患者报告结局量表（PRO）及安全性指标。结果960例患者中，768例随机分为随机治疗组，192例随机分为非随机组。联合治疗组与三联治疗组幽门螺杆菌根除率无差异(P >；0.05)。联合用药组患者中医症状评分、生活质量均有显著改善(P <；0.05)。而且不良反应发生率和幽门螺杆菌复发率较低(P <；0.05)。结论在三联疗法中加用中药可提高患者的生活质量，减少不良反应，降低复发率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.