Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Expression and correlation of the long noncoding RNA PDIA3P and FAK/TGF-β pathway in oral submucous fibrosis rats","authors":"Fan di Zhu ,&nbsp;Yu Xuan Li ,&nbsp;Ru Qian Guo ,&nbsp;Yun Xu","doi":"10.1016/j.jormas.2025.102214","DOIUrl":"10.1016/j.jormas.2025.102214","url":null,"abstract":"<div><div>Oral Submucous Fibrosis constitutes a severe condition affecting the lining of the mouth, which carries a risk of developing into oral squamous cell carcinoma, and seriously threaten individuals' lives. Currently, no specific treatment has been utilized to prevent OSF. The detailed mechanism of OSF is still elusive, and this study aims to clarify the mechanism of OSF. Methods: This study was conducted to elucidate the molecular mechanisms of the long noncoding RNA PDIA3P (lncRNA PDIA3P) and FAK/TGF-β pathway in OSF. The OSF mice model was established by injecting with injected with 1000 mg/L arecoline solution, then the blood samples and oral submucosal tissues were collected from all groups of rats for further testing. HE staining, immunofluorescence, Western blot, and qRT-PCR were then used to elucidate the molecular mechanisms of the molecular mechanisms of the lncRNA PDIA3P and FAK/TGF-β pathway in OSF. Results: The results showed that upregulation of the FAK/TGF-β signaling pathway can accelerate OSF process, while the downregulation of the FAK/TGF-β signaling pathway can prevent the OSF process. Similarly, enhanced activity of the lncRNA PDIA3P is implicated with OSF process, while reducing its level can served as a preventative method against the OSF development. Conclusion: Upregulating the lncRNA PDIA3P and FAK/TGF-β pathway can accelerate the process of OSF.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102214"},"PeriodicalIF":1.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of a large plunging ranula: A case report and review of diagnostic challenges","authors":"Abdul Karim Sharif ,&nbsp;Hedayatullah Ehsan ,&nbsp;Abdul Wahab Abri ,&nbsp;Sayed Wahabuddin Mirzad ,&nbsp;Khujasta Amin","doi":"10.1016/j.jormas.2025.102219","DOIUrl":"10.1016/j.jormas.2025.102219","url":null,"abstract":"<div><h3>Introduction</h3><div>Ranulas are mucous cysts that arise from the sublingual gland due to ductal obstruction or trauma. Plunging ranulas, a rare variant, extend into the neck and often present diagnostic challenges. Definitive surgical management is necessary to prevent recurrence and ensure successful outcomes.</div></div><div><h3>Case presentation</h3><div>A 20-year-old female presented with a slowly enlarging, painless mass in the floor of her mouth extending into the submandibular region and anterior neck. The mass had progressively increased in size over five years, affecting her appearance and mastication. MRI confirmed a large plunging ranula. The patient underwent complete surgical excision of the cyst and the sublingual gland under general anesthesia. She recovered well, with no immediate postoperative complications. Follow-up at 12 months showed no recurrence, and the patient reported full resolution of symptoms.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of early recognition and accurate diagnosis of plunging ranulas to guide appropriate surgical intervention. Complete excision of the sublingual gland remains the treatment of choice for preventing recurrence. In line with similar cases in the literature, this approach resulted in a successful outcome with no evidence of recurrence during follow-up. The findings underscore the clinical significance of individualized treatment strategies based on the extent of anatomical involvement.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102219"},"PeriodicalIF":1.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated overview of orthognathic surgery practices in France","authors":"Noémie Vanden Haute ,&nbsp;Emma Bach ,&nbsp;Pierre Bouletreau ,&nbsp;Alice Prevost ,&nbsp;Pierre Corre ,&nbsp;Louis Brochet ,&nbsp;Nicolas Graillon ,&nbsp;Andrea Varazzani","doi":"10.1016/j.jormas.2024.102210","DOIUrl":"10.1016/j.jormas.2024.102210","url":null,"abstract":"<div><h3>Introduction</h3><div>Orthognathic surgery is a fundamental component of a maxillofacial surgeon's practice. In France, 510 specialists actively practice oral and maxillofacial surgery. In OMFs, despite the existence of evidence-based recommendation that address diagnosis, treatment planning, and operating methods, each surgeon/institution has developed an individual approach towards clinical management. This study comprehensively overviews the current practices of French orthognathic surgeons.</div></div><div><h3>Methods</h3><div>A questionnaire was electronically sent to 500 oral and maxillofacial surgeons in France, some of whom practiced orthognathic surgery and some of whom did not. The answers were anonymous.</div></div><div><h3>Results</h3><div>We obtained 52 responses. With consensus on 12 of the practical, economic, and peri-operative questions. We didn't find difference on any topics where the surgeon has his residence or the age of the surgeon. Management and correction of occlusal disorders were the primary indications for osteotomy. Of all responders, 42 % were in private practice. Both virtual and conventional planning methods were used, with no clear preference for either method. During bimaxillary surgery, 76 % of surgeons initially osteotomised and stabilised the maxilla; 69 % used an intermediate splint. ERAS protocols are not used.</div></div><div><h3>Conclusion</h3><div>This study is an update and it provides new information compared a 2002 report on orthognathic surgery in France. It highlights a consensus on conventional planning but no significant influence from academic centers, age, or experience on surgical practices. New technologies and ERAS protocols are underused despite their benefits for safer surgeries. There is a lack of standardized procedures, leading to varied practices despite a national teaching program. More data and practitioner involvement are needed to develop French and European guidelines.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102210"},"PeriodicalIF":1.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective and automated facial palsy grading and outcome assessment after facial palsy reanimation surgery – A prospective observational study","authors":"Leonard Knoedler ,&nbsp;Cosima C. Hoch ,&nbsp;Thomas Schaschinger ,&nbsp;Tobias Niederegger ,&nbsp;Samuel Knoedler ,&nbsp;Christian Festbaum ,&nbsp;Iman Ghanad ,&nbsp;Rainer Pooth ,&nbsp;Barbara Wollenberg ,&nbsp;Steffen Koerdt ,&nbsp;Christian Doll ,&nbsp;Max Heiland ,&nbsp;Andreas Kehrer","doi":"10.1016/j.jormas.2024.102211","DOIUrl":"10.1016/j.jormas.2024.102211","url":null,"abstract":"<div><h3>Background</h3><div>Facial palsy (FP) is a widespread condition affecting over 3 million people annually, with a complex etiology requiring tailored, multidisciplinary management. Despite advancements, there remains a lack of reliable, automated tools for objective pre- and postoperative assessment, limiting progress in treatment optimization. This study introduces the AI Research Metrics Model (CAARISMA ® ARMM) to evaluate FP severity and outcomes following microsurgical gracilis muscle transfer.</div></div><div><h3>Methods</h3><div>We analyzed pre- and postoperative images of 20 FP patients using CAARISMA ® ARMM, which identifies 17 facial landmarks and evaluates 1,030 parameters. CAARISMA ® ARMM calculates three indices: Facial Youthfulness Index (FYI), Facial Aesthetic Index (FAI), and Skin Quality Index (SQI). All surgical procedures were performed by the senior author. Statistical analysis compared preoperative and postoperative scores using independent <em>t</em>-tests and Wilcoxon-Mann-Whitney tests, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Significant improvements were observed in the FAI scores post-surgery (<em>p</em> &lt; 0.001). In contrast, FYI and SQI scores did not show significant postoperative changes (<em>p</em> = 0.39 and <em>p</em> = 0.60, respectively). Significant gender differences emerged: females showed increased FYI scores postoperatively, while males exhibited a decline (<em>p</em> = 0.0065). Age-related variations were also significant, with younger patients showing improved SQI and older patients experiencing declines (<em>p</em> = 0.040).</div></div><div><h3>Conclusion</h3><div>The CAARISMA ® ARMM effectively captures aesthetic improvements post-reanimation. Gender and age significantly influence outcomes, underscoring the key role of personalized and adaptable assessment tools. Future studies should integrate dynamic assessments and validate the CAARISMA ® ARMM across additional patient populations. CAARISMA ® ARMM holds promise as a standardized tool in FP outcome evaluation.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102211"},"PeriodicalIF":1.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucoepidermoid carcinoma: Enhancing diagnostic accuracy and treatment strategy through machine learning models and web-based prognostic tool","authors":"Sakhr Alshwayyat ,&nbsp;Hanan M. Qasem ,&nbsp;Lina Khasawneh ,&nbsp;Mustafa Alshwayyat ,&nbsp;Mesk Alkhatib ,&nbsp;Tala Abdulsalam Alshwayyat ,&nbsp;Hamza Al Salieti ,&nbsp;Ramez M. Odat","doi":"10.1016/j.jormas.2024.102209","DOIUrl":"10.1016/j.jormas.2024.102209","url":null,"abstract":"<div><h3>Background</h3><div>Oral cancer, particularly mucoepidermoid carcinoma (MEC), presents diagnostic challenges due to its histological diversity and rarity. This study aimed to develop machine learning (ML) models to predict survival outcomes for MEC patients and pioneer a clinically accessible prognostic tool.</div></div><div><h3>Methods</h3><div>Using the SEER database (2000–2020), we constructed predictive models with five ML algorithms: Random Forest Classifier (RFC), Gradient Boosting Classifier (GBC), Logistic Regression (LR), K-Nearest Neighbors (KNN), and Multilayer Perceptron (MLP). Predictive variables were identified via Cox regression, and Kaplan-Meier analysis assessed survival trends. Model performance was validated through the area under the curve (AUC) of receiver operating characteristic (ROC) curves.</div></div><div><h3>Results</h3><div>This study included 1314 patients diagnosed with MEC of the oral cavity. The RFC demonstrated the highest predictive accuracy (AUC = 0.55), followed by the GBC and RFC (AUC = 0.53). The most affected primary site was the hard palate, followed by the retromolar and cheek mucosa. Survival rates varied with the treatment modality, with the highest rates observed in patients undergoing surgery alone. ML models have identified age, sex, and metastasis as significant prognostic factors influencing survival outcomes, underscoring the complexity and heterogeneity of MEC.</div></div><div><h3>Conclusions</h3><div>This study highlights ML's potential to enhance survival predictions and personalize treatment for MEC patients. We developed the first web-based prognostic tool, providing a novel, accessible solution for improving clinical decision-making in MEC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102209"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific postural alignment alterations due to long-face deformity in patients with maxillo-mandibular deformities","authors":"A. Kerbrat ,&nbsp;I. Rivals ,&nbsp;P. Rouch ,&nbsp;R. Valentin ,&nbsp;V. Attali ,&nbsp;T. Schouman","doi":"10.1016/j.jormas.2024.102200","DOIUrl":"10.1016/j.jormas.2024.102200","url":null,"abstract":"<div><h3>Background</h3><div>A specific pathological postural adaptation is suspected in patients exhibiting maxillo-mandibular deformity (MMD); however, none study reported a correlation between facial dimensions and posture.</div><div>In this study, we hypothesized that pathological postural adaptations are related to long-face deformity and subsequent oral breathing in patients with MMD</div></div><div><h3>Methods</h3><div>Thirty patients with MMD and 20 healthy subjects. Breathing mode, postural alignment and cephalometry were analyzed through a biplanar X-ray (EOS imaging®) of the skeleton in an upright position, followed by three-dimensional reconstruction.</div></div><div><h3>Results</h3><div>Patients with MMD exhibited hyperkyphosis of the lower region of the cervical spine (C3-C7 angle: 10.6° [3.9; 17.5] vs. 3.2° [-6.4; 7.6], <em>p</em> &lt; 0.01), forward head posture (OD-C7 angle: 10.5° [8.5; 15.1] vs. 6.2° [3.0; 8.4], <em>p</em> &lt; 0.01), and backward sagittal balance compared with controls (sagittal vertical axis:15.7 mm [-25.9; -5.2] vs. -1.4 mm [-17.8; 7.0], <em>p</em> = 0.014). Cervical hyperkyphosis, the forward head posture, and the backward sagittal balance were related to higher values of the Frankfort-mandibular plane angle (a cephalometric variable used to assess face length). In patient with MMD, oral breathing was correlated to the FMA angle.</div></div><div><h3>Conclusion</h3><div>MMD is associated with a specific pathological postural adaptation which is correlated with Long-face deformity and oral breathing. Our results suggest that the altered posture originates from the upper airways.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102200"},"PeriodicalIF":1.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway","authors":"Wei Xu ,&nbsp;Shengwen Liu ,&nbsp;Wenjun Yang","doi":"10.1016/j.jormas.2024.102204","DOIUrl":"10.1016/j.jormas.2024.102204","url":null,"abstract":"<div><h3>Background</h3><div>UL16-binding protein 2 (ULBP2) is significantly overexpressed in diverse cancers, it may also serve as a potential prognostic factor. Nonetheless, the mechanism of action and functions associated with ULBP2 in head and neck squamous cell carcinoma(HNSCC) are unexplored. This study aims to clarify the role and mechanism of ULBP2 in HNSCC and determine whether this molecule promotes tumor progression through modulation multiple downstream MAPK signaling.</div></div><div><h3>Materials and methods</h3><div>The Cancer Genome Atlas (TCGA) database was used to find out the mRNA transcript levels of ULBP2 in people with HNSCC. Here, the impact of ULBP2 on proliferation, migration and invasion abilities was evaluated in HNSCC cell lines using multi-methods. To understand the effect of ULBP2 on tumor-related signaling pathways, Genomic Enrichment Analysis (GSEA) was performed. We did an in vivo cancer study to learn more about the part ULBP2 plays in the growth of tumors. Moreover, Western blot was used to determine the signaling pathways influenced by ULBP2.</div></div><div><h3>Results</h3><div>ULBP2 is highly expressed in HNSCC cells. In addition, we saw that HNSCC patients who had high levels of ULBP2 had a poor prognosis. Silencing ULBP2 expression reduces invasive and metastatic abilities of HNSCC cells Mechanistic experiments showed the function of ULBP2 in vitro and in vivo tumorigenic assays potentially associated with MAPK pathway.</div></div><div><h3>Conclusion</h3><div>We validated that ULBP2 promotes HNSCC cell progression by regulating the MAPK pathway. These findings are crucial for understanding the process of HNSCC pathogenesis and progression caused by ULBP2.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102204"},"PeriodicalIF":1.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of onodera's prognostic nutritional in predicting the prognosis of tongue squamous cell carcinoma","authors":"Satoshi Fukuzawa,&nbsp;Kenji Yamagata,&nbsp;Ryo Takasaki,&nbsp;Fumihiko Uchida,&nbsp;Naomi Ishibashi-Kanno,&nbsp;Hiroki Bukawa","doi":"10.1016/j.jormas.2024.102201","DOIUrl":"10.1016/j.jormas.2024.102201","url":null,"abstract":"<div><h3>Purpose</h3><div>To clarify the effects of preoperative nutritional evaluation on the prognosis of patients with tongue squamous cell carcinoma.</div></div><div><h3>Methods</h3><div>This retrospective cohort study involves 126 consecutive patients who underwent radical surgery as their initial treatment and received treatment for &gt;3 years. The markers considered in this study are GGT (γ-GTP), CAR (C-reactive protein (CRP)-to-Alb Ratio), GLR (GGT-to-Lymphocytes Ratio), GPR (GGT-to-Platelet ratio), GNR (GGT-to-Neutrophil ratio), NLR (Neutrophil-to-Lymphocyte ratio), PLR (platelet-to-lymphocytes ratio), OPNI (Onodera`s prognostic nutritional index), PINI (Prognostic Immune and Nutritional Index) and Albumin (Alb). Each marker was calculated from blood test results up to one month before the initial surgery to assess overall survival (OS) and disease-free survival (DFS).</div></div><div><h3>Results</h3><div>Univariate analysis of OS identified the depth of invasion (DOI <em>P</em> = 0.004), stage classification (<em>P</em> &lt; 0.001), Body mass index (BMI) (<em>P</em> = 0.007), OPNI (<em>P</em> = 0.005), prognostic inflammatory and nutritional indices (PINI, <em>P</em> = 0.011), and albumin (Alb) (<em>P</em> = 0.006) as significant predictors. Cox regression analysis revealed significant differences in BMI, pathological grade, and OPNI. The OPNI cut-off value was 51.05, indicating its effectiveness in predicting tongue cancer prognosis. With regard to DFS, only BMI showed a significant difference, with no notable difference among other markers. Conclusion: The OPNI may be a useful prognostic factor for tongue cancer.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102201"},"PeriodicalIF":1.8,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of postoperative radiation therapy in early-stage tongue carcinoma: A systematic review and meta-analysis","authors":"Shiwang Yuan ,&nbsp;Jiayi Chen ,&nbsp;Guangyi Cheng ,&nbsp;Sijia Deng ,&nbsp;Jiang Wang ,&nbsp;Bo Wang ,&nbsp;Liantao Li","doi":"10.1016/j.jormas.2024.102192","DOIUrl":"10.1016/j.jormas.2024.102192","url":null,"abstract":"<div><div>Although the overall prognosis for early-stage oral tongue squamous cell carcinoma is good, a significant portion of patients still experience locoregional recurrence and affect the disease-specific survival. At present, whether more aggressive postoperative radiation therapy in this particular patient population should be taken is still controversial. The analysis exhibited that disease-free survival (OR = 0.53, 95 % CI:0.35–0.81; <em>P</em> = 0.003) and locoregional recurrence-free survival (OR = 0.59, 95 % CI:0.38–0.93; <em>P</em> = 0.022) was significant improved in patients received radiotherapy compared to surgery alone. However, radiotherapy failed to improve overall survival (HR = 1.06 95 % CI:0.42–2.64, <em>P</em> = 0.901). Furthermore, two studies reported overall survival based on depth of invasion as well. The pooled OR was 1.65 (95 % CI:0.31–8.91, <em>P</em> = 0.221) and no survival benefit was observed for early-stage patients underwent adjuvant radiotherapy according to depth of invasion. Current evidence is insufficient to independently support the depth of invasion as an effective indication for radiotherapy of early tongue cancer.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 3","pages":"Article 102192"},"PeriodicalIF":1.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate oral feeding after free-flap reconstruction of the oral cavity","authors":"Hugo Poncet,&nbsp;Franck Delanoë,&nbsp;Frédéric Lauwers,&nbsp;Chris Passalboni,&nbsp;Pierre Molla-de-Testa,&nbsp;Alice Prevost","doi":"10.1016/j.jormas.2024.102196","DOIUrl":"10.1016/j.jormas.2024.102196","url":null,"abstract":"<div><h3>Aim</h3><div>There remains no consensus on the definition or value of early oral feeding after head and neck surgery. The main objective of this study was to determine how immediate oral feeding (IOF) with soft diet within 2 days following free-flap reconstruction of the oral cavity affected severe post-operative morbidity within 30 days and length of hospital stay (LoS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study was carried out in 2021–2023 in our tertiary hospital center. The associations between severe post-operative morbidity and LoS with the independent variable of IOF were analyzed by multivariate regression analysis. We also examined the factors associated with delayed oral feeding (DOF); lack of oral feeding within 10 post-operative days. The confounding variables adjusted for were demographic-related (age, sex), comorbidity-related (ASA score, undernutrition, prior history), and surgery-related (substance loss type/location, flap type).</div></div><div><h3>Results</h3><div>Inclusion was 132 patients: <em>n</em> = 29/132 (22 %) IOF patients versus <em>n</em> = 103/132 (78 %) patients undergoing oral feeding after ≥3 post-operative days. IOF was found independently associated with reduced severe post-operative morbidity within 30 days (AOR 0.3[0.1–0.8], <em>p</em> = 0.01) and shorter length of stay (AEE -6.7 [-11.8–-1.6], <em>p</em> = 0.01) compared to oral feeding after ≥3 post-operative days. DOF was found positively associated with cardiovascular history (AOR 2.7[1.1–7.3], <em>p</em> = 0.04) but negatively associated with a history of head and neck surgery with radiotherapy (AOR 0.4[0.1–0.8], <em>p</em> = 0.05).</div></div><div><h3>Conclusion</h3><div>Protocols for post-operative oral feeding should consider IOF. Criteria for good candidates for IOF require further definition for surgeons to implement IOF more widely.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102196"},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}