Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Application of recombinant human epidermal growth factor in oral and maxillofacial trauma and its impact on healing time","authors":"Xuming Wang,&nbsp;Xiaoli Ji","doi":"10.1016/j.jormas.2025.102326","DOIUrl":"10.1016/j.jormas.2025.102326","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the role of recombinant human epidermal growth factor<span> (rhEGF) in promoting the healing of oral and maxillofacial (OMF) trauma, analyze its specific impact on healing time, and explore the biological mechanisms of rhEGF in facilitating wound recovery.</span></div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 135 patients with OMF trauma treated at our hospital from May 2023 to May 2024. Patients were divided into an observation group (72 cases) receiving rhEGF treatment and a control group (63 cases) receiving conventional therapy. Clinical efficacy, inflammatory responses, perioperative indicators, and other outcomes were compared between the two groups.</div></div><div><h3>Results</h3><div>The observation group demonstrated a higher treatment efficacy rate (94.46 %) compared to the control group (77.78 %) (χ² = 16.151, <em>P</em><span> &lt; 0.001). In the perioperative period, the observation group exhibited shorter healing time (</span><em>t</em> = 6.038, <em>P</em><span> &lt; 0.001), reduced incision edema duration (</span><em>t</em> = 12.330, <em>P</em><span> &lt; 0.001), and lower post-treatment VAS scores (</span><em>t</em> = 10.400, <em>P</em> &lt; 0.001), though surgical duration was slightly longer (<em>t</em> = -24.145, <em>P</em><span> &lt; 0.001). Inflammatory marker analysis revealed that EGF levels were higher (</span><em>t</em> = -13.969, <em>P</em> &lt; 0.001), while IL-6 (<em>t</em> = 10.458, <em>P</em><span> &lt; 0.001) and CRP levels (</span><em>t</em> = 14.092, <em>P</em><span> &lt; 0.001) were lower in the observation group than in the control group. Scar hyperplasia occurred in only 2 cases in the observation group compared to 13 cases in the control group (χ² = 10.848, </span><em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div><span>rhEGF promotes wound healing in OMF trauma, accelerating recovery, shortening healing time, reducing inflammatory responses, and minimizing scar </span>hyperplasia.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102326"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based multimodal CT/MRI image fusion and segmentation strategies for surgical planning of oral and maxillofacial tumors: A pilot study","authors":"Bin-Zhang Wu ,&nbsp;Lei-Hao Hu ,&nbsp;Si-Fan Cao ,&nbsp;Ji Tan ,&nbsp;Nian-Zha Danzeng ,&nbsp;Jing-Fan Fan ,&nbsp;Wen-Bo Zhang ,&nbsp;Xin Peng","doi":"10.1016/j.jormas.2025.102324","DOIUrl":"10.1016/j.jormas.2025.102324","url":null,"abstract":"<div><h3>Purpose</h3><div>This pilot study aims to evaluate the feasibility and accuracy of deep learning-based multimodal computed tomography/magnetic resonance imaging (CT/MRI) fusion and segmentation strategies for the surgical planning of oral and maxillofacial tumors.</div></div><div><h3>Materials and methods</h3><div>This study enrolled 30 oral and maxillofacial tumor patients visiting our department between 2016 and 2022. All patients underwent enhanced CT and MRI scanning of the oral and maxillofacial region. Furthermore, three fusion models (Elastix, ANTs, and NiftyReg) and three segmentation models (nnU-Net, 3D UX-Net, and U-Net) were combined to generate nine hybrid deep learning models that were trained. The performance of each model was evaluated <em>via</em> the Fusion Index (FI), Dice similarity coefficient (Dice), 95th-percentile Hausdorff distance (HD95), mean surface distance (MSD), precision, and recall analysis.</div></div><div><h3>Results</h3><div>All three image fusion models (Elastix, ANTs, and NiftyReg) demonstrated satisfactory accuracy, with Elastix exhibiting the best performance. Among the tested segmentation models, the highest degree of accuracy for segmenting the maxilla<span> and mandible was achieved by combining NiftyReg and nnU-Net. Furthermore, the highest overall accuracy of the nine hybrid models was observed with the Elastix and nnU-Net combination, which yielded a Dice coefficient of 0.89 for tumor segmentation.</span></div></div><div><h3>Conclusion</h3><div>In this study, deep learning models capable of automatic multimodal CT/MRI image fusion and segmentation of oral and maxillofacial tumors were successfully trained with a high degree of accuracy. The results demonstrated the feasibility of using deep learning-based image fusion and segmentation to establish a basis for virtual surgical planning.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102324"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of external incision in correcting bulbous nasal tip caused by skin thickness in East Asian patients","authors":"Hongli Zhao ,&nbsp;Xiancheng Wang,&nbsp;Jiandong Ye,&nbsp;Pei Zou,&nbsp;Kai Yang,&nbsp;Weiliang Zeng,&nbsp;Zhihua Qiao,&nbsp;Yikun Ju","doi":"10.1016/j.jormas.2025.102327","DOIUrl":"10.1016/j.jormas.2025.102327","url":null,"abstract":"<div><h3>Background</h3><div>Bulbous nasal tips in East Asian patients are often caused by thick skin and soft tissue hypertrophy, presenting challenges in rhinoplasty. This study evaluates the efficacy and safety of supratip excision combined with cartilage reshaping to address nasal tip hypertrophy and minimize scarring.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on patients who underwent bulbous nasal tip correction from January 2021 to October 2023. The surgical approach involved midline elliptical supratip excision, cartilage grafting (from septum, rib, or ear), and lateral crural adjustments. Outcomes were assessed using anthropometric measurements (nasal length, tip projection [NTP], nasolabial angle [NLA]), the Rhinoplasty Outcome Evaluation (ROE) score, and the Patient and Observer Scar Assessment Scale (POSAS).</div></div><div><h3>Results</h3><div>Thirteen East Asian patients (mean age: 29.23 years) met the inclusion criteria. Postoperative results showed a 20 % reduction in nasal length (7.29 cm to 5.83 cm, <em>p</em> &lt; 0.001), 8.3 % increase in NTP (18.98 mm to 20.56 mm, <em>p</em> &lt; 0.001), and 7.2° improvement in NLA (82.59° to 88.64°, <em>p</em> &lt; 0.001). ROE scores improved significantly (<em>p</em> &lt; 0.001). Scar satisfaction was 96.16 %, with minimal irregularities noted in 15.38 % of cases.</div></div><div><h3>Conclusion</h3><div>Supratip excision effectively corrects bulbous nasal tips in East Asian patients, resulting in refined nasal contours and high patient satisfaction. Careful patient selection and scar management are paramount to ensure the success of the procedure. Further studies with larger cohorts are needed to confirm long-term outcomes.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102327"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of bisphosphonates in the treatment of diffuse sclerosing osteomyelitis: A case report with systematic review of the literature","authors":"Rayssa Nunes Villafort ,&nbsp;Luiza Vale Coelho ,&nbsp;Gustavo Henrique Martins ,&nbsp;Guilherme Veloso Ramos ,&nbsp;Marcio Bruno Figueiredo Amaral","doi":"10.1016/j.jormas.2025.102386","DOIUrl":"10.1016/j.jormas.2025.102386","url":null,"abstract":"<div><div><span>Diffuse sclerosing osteomyelitis is an uncommon and poorly understood chronic </span>inflammatory disease<span><span>, for which many etiological theories and treatment modalities have been suggested. Recurrent swelling and pain in the lower jaw are typical symptoms, often accompanied by trismus<span><span>. The management of diffuse sclerosing osteomyelitis<span> is a challenging and often long term with several drug therapies being reported in the literature, including anti-resorptive therapies. This study aimed to investigate the effects of </span></span>bisphosphonates therapy in diffuse sclerosing osteomyelitis patients and report an atypical case in a young patient. A </span></span>systematic review<span><span> of the literature was performed including 130 patients with diffuse sclerosing osteomyelitis treated with bisphosphonates. Complete resolution of the clinical symptoms, with regression of pain and swelling were reported in 105 (80,76 %) patients. </span>Pamidronate IV was the most frequent medication applied with stable and satisfactory long-term results. In this study, the patient was treated with intravenous administration of 45 mg of pamidronate disodium, once a day, for three continues days. The follow-up was uneventful with complete regression of the clinical symptoms. Bisphosphonates seem to be a good option in the treatment of diffuse sclerosing osteomyelitis in the jaw, especially pamidronate IV.</span></span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102386"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of craniofacial bone density based on embryonic origin and ossification patterns","authors":"Seok Woo Hong ,&nbsp;Kyung Jae Yoon ,&nbsp;Jeong-Hyun Kang","doi":"10.1016/j.jormas.2025.102388","DOIUrl":"10.1016/j.jormas.2025.102388","url":null,"abstract":"<div><h3>Objective</h3><div>Bones develop from various embryonic origins and are formed through either endochondral or intramembranous ossification. This study aimed to explore how bone density varies across bones with different embryonic origins and ossification processes.</div></div><div><h3>Materials and methods</h3><div><span><span>A total of 43 participants (12 males; mean age 68.3 ± 9.9 years) with a history of falls and suspected facial and wrist fractures were included. Participants were subsequently divided into three groups based on levels of </span>osteoporosis based on the T-score of the areal bone density (aBMD) at the </span>femoral neck<span><span>. aBMD was measured using dual-energy x-ray absorptiometry<span><span> (DEXA) of the total hip, femoral neck, and lumbar spine. Bone densities of the </span>distal radius<span>, hyoid, and craniofacial bones, including mandible, </span></span></span>maxilla<span>, frontal, parietal, zygomatic, and temporal bones<span> were assessed using 3D reconstructed computed tomography images.</span></span></span></div></div><div><h3>Results</h3><div>The average Hounsfield Unit of the reconstructed distal radius model varies significantly across osteoporosis levels. However, no significant differences were found in the craniofacial bones or hyoid bone<span> models. Significant correlations were identified between bone densities of the axial and appendicular skeletons. In contrast, the craniofacial bones exhibited strong internal correlations but minimal associations with those of axial or appendicular bones, revealing distinct bone density patterns influenced by embryonic origin and ossification processes.</span></div></div><div><h3>Conclusion</h3><div>Different embryonic origins and ossification processes give rise to distinct bone density patterns. These results underscore the importance of careful considerations beyond DEXA outcomes when predicting fracture risk or planning the procedures involving bone preparation, particularly in craniofacial regions.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102388"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of human telomerase reverse transcriptase (hTERT) expression in cancer progression and as a diagnostic biomarker in oral squamous cell carcinoma","authors":"Vasanthi V ,&nbsp;Kavitha Sanjeev ,&nbsp;Rajkumar Krishnan","doi":"10.1016/j.jormas.2025.102433","DOIUrl":"10.1016/j.jormas.2025.102433","url":null,"abstract":"<div><h3>Background</h3><div><span><span>Telomerase is composed of a rate-limiting </span>telomerase reverse transcriptase<span> catalytic subunit<span> and an RNA </span></span></span>template<span><span> component. Telomerase reverse transcriptase (hTERT) is an essential unit of telomerase. The study aimed to immunohistochemically analyze the expression of hTERT in different grades of </span>oral squamous cell carcinoma in relation to the clinicopathological findings.</span></div></div><div><h3>Methodology</h3><div><span><span>Tissues procured from 60 histopathologically confirmed cases of oral squamous cell carcinoma were subjected to </span>immunohistochemistry to determine the expression of hTERT. Statistical significance was set at </span><em>p</em> &lt; 0.05. Chi-square test was employed to compare the staining intensity between the groups. Kappa analysis was done to measure the interobserver agreement (κ = 0.84).</div></div><div><h3>Results</h3><div>The size of the tumor ranged from 1.5 cm to 5.5 cm approximately. Regional lymph node metastasis<span> was noted in 2 patients with poorly differentiated OSCC. Distant metastasis was not identified in any of the enrolled patients. 54/60 OSCC patients showed hTERT expression.</span></div></div><div><h3>Conclusion</h3><div>Though we did not find a significant difference in hTERT expression in our study, the role of hTERT in cancer progression and the increase in expression from well-differentiated OSCC to poorly differentiated OSCC suggests that hTERT can serve as a diagnostic biomarker in early stages of OSCC.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102433"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telescopic Genioplasty: A novel technique for chin feminization in facial feminization surgery","authors":"Javier Gutiérrez Santamaría,&nbsp;Jorge Masiá Gridilla,&nbsp;Miguel Pérez de Perceval Tara,&nbsp;Carlos Bailón Berrio,&nbsp;Luis Capitán,&nbsp;Daniel Simon","doi":"10.1016/j.jormas.2025.102445","DOIUrl":"10.1016/j.jormas.2025.102445","url":null,"abstract":"<div><div><span>Chin modification plays a critical role in Facial Feminization Surgery (FFS) due to its impact on gender perception. Current techniques, including high-speed burring and </span>osteotomies<span><span>, may leave some patients with an undesired round chin appearance. This study introduces the combination of telescopic genioplasty and chin feminization, a novel, minimally invasive approach designed to feminize the chin by reducing its dimensions, adjusting its sagittal position, and creating a more tapered appearance. This study involved 22 transgender women who underwent either isolated telescopic genioplasty or a combination of chin feminization and telescopic genioplasty from January to December 2023. Virtual surgical planning, 3D-printed cutting guides, and customized titanium miniplates were used. Outcomes were assessed based on surgical time, chin advancement, and complication rates. Telescopic genioplasty offers a safe, effective, and </span>minimally invasive technique for chin feminization, with favorable aesthetic outcomes and low complication rates.</span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102445"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress distribution in implant-supported conometric single crown restorations: A finite element analysis","authors":"Sinem Vural ,&nbsp;Buket Evren ,&nbsp;Coşkun Yıldız","doi":"10.1016/j.jormas.2025.102484","DOIUrl":"10.1016/j.jormas.2025.102484","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of the present study was to evaluate the effect of connection, restorative material type<span>, and loading forces on the stress distribution in implant-supported conometric single crown restorations using a three-dimensional finite element analysis method.</span></div></div><div><h3>Methods</h3><div>Restorations are produced using two different all-ceramic materials used in maxillary right premolar<span> conometric abutments and caps (Conometeric abutment EV, Conometeric Final Cap, Dentsply Implants, Sweden) on implants with three different types of connection: morse taper connection (MTC) (Ankylos, Dentsply Implants, Sweden), conical connection (CC) (Astra-Tech OsseoSpeed EV, Dentsply Implants, Sweden), and internal flat connection (IFC) (Xive, Dentsply, Sweden). Three-dimensional finite element analysis was used to evaluate the amount and distribution of stress around implants under different vertical and oblique loading conditions.</span></div></div><div><h3>Results</h3><div><span>The maximum stress distribution in the implant abutment contact area in the IFC was </span><u>565.44</u> MPa and screw peak stress values were determined to be <u>518.96</u><span> MPa in the transition zone for MTC. MTC caused the lowest bone stress, although there was no significant difference between the connection systems in terms of material type. The LDS material exhibited the greatest stress on the conometric cap for IFC (447.52 MPa) under oblique loading conditions.</span></div></div><div><h3>Conclusion</h3><div>Stress on the bone surface and implant abutment contact was higher in the IFC group. IFC has a disadvantage in term of increases the possibility of bone destruction.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102484"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stensen’ s duct penetration and sialolith formation: a rare complication of thread lifting surgery","authors":"Dan-Ni Zheng ,&nbsp;Xiao-Yun Xu ,&nbsp;Xiao-Tong Ling ,&nbsp;Deng-Gao Liu","doi":"10.1016/j.jormas.2025.102489","DOIUrl":"10.1016/j.jormas.2025.102489","url":null,"abstract":"<div><div><span>Sialolithiasis is a relatively frequent occurrence, but the etiology of </span>sialoliths<span><span> remains unclear. Foreign bodies might enter the salivary duct and induce sialoliths by retrograde migration or penetrating trauma. Several reports have involved salivary duct stones formed around a foreign body, such as fishbone, vegetable seed, grass blade, et al. However, an iatrogenic foreign body-induced sialolith is scarcely reported. Thread lifting is a </span>minimally invasive technique<span> for facial rejuvenation<span> with the advantages of short recovery, good-lifting and high satisfaction rate. The injury of the Stensen’s duct was scarcely found in the complications of thread lifting. This paper reports three cases of sialoliths formed by the thread penetrating the Stensen’s duct after facial thread lifting. These cases were treated successfully under endoscopy, though the lifting thread was not extracted in one case. The etiology of sialoliths is reviewed, and the complications of thread lifting are discussed.</span></span></span></div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 5","pages":"Article 102489"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOTCH gene pattern predicts prognosis, immune infiltration, and drug response in Head and Neck squamous cell carcinoma","authors":"Shanliang Ye ,&nbsp;Lin Huang ,&nbsp;Liyu Ma ,&nbsp;Lingli Xu ,&nbsp;Liehui Liu ,&nbsp;Jiezhuang Li ,&nbsp;Yufang Zhang ,&nbsp;Baojuan Gao ,&nbsp;Yuran Ji ,&nbsp;Zhongwen Zheng ,&nbsp;Hanguo Guo","doi":"10.1016/j.jormas.2025.102582","DOIUrl":"10.1016/j.jormas.2025.102582","url":null,"abstract":"<div><h3>Background</h3><div>Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer with poor prognosis. Although NOTCH signaling is frequently inactivated in HNSCC, the prognostic significance of NOTCH-related genes and their link to the tumor microenvironment remain unclear.</div></div><div><h3>Methods</h3><div>NOTCH-related genes were identified in HNSCC patients through univariate Cox regression and differential expression analyses. A prognostic risk model (NOTCH score) was constructed using LASSO regression. The association between the NOTCH score and clinical outcomes, immune infiltration, therapy response sensitivity was comprehensively evaluated. Single-cell RNA sequencing and immunohistochemistry were used to assess the cellular and tissue distribution of risk genes.</div></div><div><h3>Results</h3><div>Seven candidate genes (COL28A1, EFEMP1, FGF9, FMOD, ITGA5, ROBO1, and THBS1) were selected to construct the NOTCH-based prognostic model. Patients were stratified into high- and low-risk groups based on the median NOTCH score. High-risk patients exhibited significantly worse survival compared to the low-risk group. ROC analysis demonstrated robust prognostic performance, with AUC values exceeding 0.7 for 3-year survival in both training and validation cohorts. High NOTCH scores were associated with an immunosuppressive tumor microenvironment and poor response to immunotherapy. Drug sensitivity analysis revealed that high-risk patients were more sensitive to agents such as CMK, Parthenolide, and Thapsigargin. At both the single-cell and protein levels, the seven genes were predominantly expressed in fibroblasts and endothelial cells, suggesting their potential involvement in tumor stromal remodeling and microenvironment regulation.</div></div><div><h3>Conclusion</h3><div>We developed and validated a NOTCH-based prognostic model with strong predictive power in HNSCC. The NOTCH score may help assess immune status, predict treatment response, and guide personalized therapy.</div></div>","PeriodicalId":55993,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":"126 6","pages":"Article 102582"},"PeriodicalIF":2.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}