{"title":"Application of recombinant human epidermal growth factor in oral and maxillofacial trauma and its impact on healing time.","authors":"Xuming Wang, Xiaoli Ji","doi":"10.1016/j.jormas.2025.102326","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the role of recombinant human epidermal growth factor (rhEGF) in promoting the healing of oral and maxillofacial (OMF) trauma, analyze its specific impact on healing time, and explore the biological mechanisms of rhEGF in facilitating wound recovery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 135 patients with OMF trauma treated at our hospital from May 2023 to May 2024. Patients were divided into an observation group (72 cases) receiving rhEGF treatment and a control group (63 cases) receiving conventional therapy. Clinical efficacy, inflammatory responses, perioperative indicators, and other outcomes were compared between the two groups.</p><p><strong>Results: </strong>The observation group demonstrated a higher treatment efficacy rate (94.46%) compared to the control group (77.78%) (χ² = 16.151, P < 0.001). In the perioperative period, the observation group exhibited shorter healing time (t = 6.038, P < 0.001), reduced incision edema duration (t = 12.330, P < 0.001), and lower post-treatment VAS scores (t = 10.400, P < 0.001), though surgical duration was slightly longer (t = -24.145, P < 0.001). Inflammatory marker analysis revealed that EGF levels were higher (t = -13.969, P < 0.001), while IL-6 (t = 10.458, P < 0.001) and CRP levels (t = 14.092, P < 0.001) were lower in the observation group than in the control group. Scar hyperplasia occurred in only 2 cases in the observation group compared to 13 cases in the control group (χ² = 10.848, P < 0.001).</p><p><strong>Conclusion: </strong>rhEGF promotes wound healing in OMF trauma, accelerating recovery, shortening healing time, reducing inflammatory responses, and minimizing scar hyperplasia.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102326"},"PeriodicalIF":2.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology Oral and Maxillofacial Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jormas.2025.102326","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to investigate the role of recombinant human epidermal growth factor (rhEGF) in promoting the healing of oral and maxillofacial (OMF) trauma, analyze its specific impact on healing time, and explore the biological mechanisms of rhEGF in facilitating wound recovery.
Methods: A retrospective analysis was conducted on 135 patients with OMF trauma treated at our hospital from May 2023 to May 2024. Patients were divided into an observation group (72 cases) receiving rhEGF treatment and a control group (63 cases) receiving conventional therapy. Clinical efficacy, inflammatory responses, perioperative indicators, and other outcomes were compared between the two groups.
Results: The observation group demonstrated a higher treatment efficacy rate (94.46%) compared to the control group (77.78%) (χ² = 16.151, P < 0.001). In the perioperative period, the observation group exhibited shorter healing time (t = 6.038, P < 0.001), reduced incision edema duration (t = 12.330, P < 0.001), and lower post-treatment VAS scores (t = 10.400, P < 0.001), though surgical duration was slightly longer (t = -24.145, P < 0.001). Inflammatory marker analysis revealed that EGF levels were higher (t = -13.969, P < 0.001), while IL-6 (t = 10.458, P < 0.001) and CRP levels (t = 14.092, P < 0.001) were lower in the observation group than in the control group. Scar hyperplasia occurred in only 2 cases in the observation group compared to 13 cases in the control group (χ² = 10.848, P < 0.001).
Conclusion: rhEGF promotes wound healing in OMF trauma, accelerating recovery, shortening healing time, reducing inflammatory responses, and minimizing scar hyperplasia.
期刊介绍：
J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics.
Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.
All manuscripts submitted to the journal are subjected to peer review by international experts, and must:
Be written in excellent English, clear and easy to understand, precise and concise;
Bring new, interesting, valid information - and improve clinical care or guide future research;
Be solely the work of the author(s) stated;
Not have been previously published elsewhere and not be under consideration by another journal;
Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed.
Under no circumstances does the journal guarantee publication before the editorial board makes its final decision.
The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.
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