Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Diagnosis and management strategies of infectious and chronic diffuse sclerosing osteomyelitis: a retrospective study.","authors":"Meriaux Océane, Preuss Pauline, Dugast Sophie, Helios Bertin, Corre Pierre, LE Goff Benoit","doi":"10.1016/j.jormas.2025.102513","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102513","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic diffuse sclerosing osteomyelitis (CDSO) is a rare, non-suppurative mandibular condition that often mimics infectious osteomyelitis (IO), making diagnosis and management challenging. This study aimed to identify key clinical, radiological, histopathological, and therapeutic features distinguishing CDSO from IO and to propose a diagnostic and treatment strategy.</p><p><strong>Materials and methods: </strong>We conducted a retrospective descriptive study of 43 patients treated for mandibular osteomyelitis at Nantes University Hospital between 2007 and 2020. Clinical records, imaging, histological and microbiological data, and treatment outcomes were analyzed and compared between patients diagnosed with CDSO and those with IO.</p><p><strong>Results: </strong>CDSO affected mainly middle-aged women and showed a high recurrence rate despite prolonged antibiotic use. It was characterized by mononuclear infiltrates, medullary fibrosis, and bone condensation without abscess formation. In contrast, IO showed neutrophilic infiltrates, bacterial clusters, and osteolysis often with soft tissue abscesses. Antibiotics were effective in IO but frequently failed in CDSO. Anti-inflammatory and rheumatologic treatments, including NSAIDs, corticosteroids, bisphosphonates, and biotherapies, showed variable but encouraging responses in CDSO. Imaging differences, particularly on CBCT and CT, helped differentiate the two entities.</p><p><strong>Discussion: </strong>This study highlights the need for a multidisciplinary approach, including rheumatologic expertise, in the management of CDSO. The lack of gold standard diagnostic criteria complicates classification, yet histopathology and radiology provide helpful orientation. Larger prospective studies are warranted to validate our findings and optimize treatment protocols for CDSO.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102513"},"PeriodicalIF":2.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive approach for the surgical treatment of Rhinophyma: the effectiveness of Microdebrider.","authors":"Stefania Troise, Emanuele Carraturo, Rebecca Napolitano, Paola Bonavolontà, Antonio Romano, Pasquale Piombino","doi":"10.1016/j.jormas.2025.102512","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102512","url":null,"abstract":"<p><strong>Background: </strong>Rhinophymas are disfiguring disorders of the face that represent the end-stage of sebaceous gland hyperplasia in patients with rosacea. The literature reports different surgical approaches to treat this pathology, but the Microdebrider have proved to be successful in sinonasal surgery as it enables precise control of tissue that needs to be removed, proving to be a safe approach, with good aesthetic results.</p><p><strong>Objective: </strong>The aim of this paper is to conduct a pilot study on 10 patients with rhinophyma treated with the use of microdebrider, comparing our results with the most recent articles in literature, carrying out a narrative review.</p><p><strong>Methods: </strong>10 cases of rhinophyma were presented. All patients underwent mininvasive surgical treatment based on the use of the Microdebrider and different long-term medications with Fitostimoline gauzes or Condress in the postoperative management. All patients underwent periodic outpatient follow-ups, with a minimum follow-up of 12 months. The aesthetic results were compared with the use of the Vancouver scar scale.</p><p><strong>Results: </strong>In all cases, the cosmetic outcomes, at 1 year follow-up, were satisfactory, regardless of the postoperative used medication. The mean of the total VSS values for patients treated with the combination of Fitostimoline gauze and gentamicin was 2.29±1.03SD, while for patients treated with Condress gauze the mean was 2.33±0.47SD. The literature review also confirms these results.</p><p><strong>Conclusions: </strong>Microdebrider is a valuable tool for precise and effective surgical treatment of rhinophyma, ensuring good aesthetic results, regardless of the type of dressing used in post-operative management.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102512"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D soft tissue segmentation for guided botulinum toxin injection in lateral pterygoid muscle.","authors":"Nourhan Raafa, Aya A Sakr, Lydia N Melek","doi":"10.1016/j.jormas.2025.102510","DOIUrl":"10.1016/j.jormas.2025.102510","url":null,"abstract":"<p><p>The botulinum toxin administration into the lateral pterygoid muscle has shown promising outcomes in anterior disc displacement with reduction. The deep location of the muscle and its proximity to vital structures and interindividual variation necessitate the use of guidance techniques. This technical report describes a new guidance technique which provides lateral pterygoid muscle segmentation using CT with soft tissue window for 3D augmented environment of the muscle together with its surrounding skeletal and dental structures.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102510"},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and dimensions of the nasopalatine duct according to facial biotype in Peruvian adults with cone beam computed tomography. An observational study.","authors":"Lissette Lourdes Santos-Soto, Luis Ernesto Arriola-Guillén, Roxana Patricia López-Ramos","doi":"10.1016/j.jormas.2025.102509","DOIUrl":"10.1016/j.jormas.2025.102509","url":null,"abstract":"<p><strong>Introduction: </strong>The nasopalatine duct (NPD) is an important anatomical structure during maxillary surgical planning. Its characteristics are influenced by craniofacial development, which defines the facial biotype. This study aimed to determine the relationships between the dimensions and morphologies of the nasalopalatine canal and facial biotype in adults.</p><p><strong>Materials and methods: </strong>This observational and retrospective study analysed 150 cone beam computed tomography (CBCT) scans from adult patients at a radiology center. The dimensions and morphology of the nasopalatine duct (NPD) were assessed via ProMax 3D Mid® equipment and Romexis® Viewer Software, version 6.4.1. Descriptive and inferential statistical analyses were performed to examine the study variables, and multiple linear regression analyses were conducted (significance level set at p < 0.05).</p><p><strong>Results: </strong>The mean length of the NPD in the sagittal section was 10.9 ± 2.8 mm in dolichofacial subjects, 10.6 ± 2.6 mm in mesofacial subjects, and 11.4 ± 2.9 mm in brachyfacial subjects. No statistically significant differences in NPD dimensions or morphology were found among the different facial biotypes (>0.05). However, at the level of the incisive foramen, males presented a significantly larger NPD than females did, with a mean difference of 2.64 mm (95 % CI: 0.34-4.94 mm).</p><p><strong>Conclusion: </strong>This study revealed no relationship between facial biotype and NPD characteristics, except for a larger duct in males. However, it provides region-specific data for a Peruvian adult population, which has been underrepresented in previous research.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102509"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Role of Interleukin-37 in Oral Lichen Planus: Regulation of Jurkat Cell Glycolysis through the mTOR Pathway.","authors":"Tingting Wu, Yang Bai, Fangchun Chen","doi":"10.1016/j.jormas.2025.102511","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102511","url":null,"abstract":"<p><strong>Objectives: </strong>Oral lichen planus (OLP), a potential malignant disease of the oral mucosa, is a chronically inflamed condition that impacts the quality of life of patients. Interleukin-37 (IL-37) is a potent innate and acquired immunosuppressive factor in autoimmune diseases, but its specific role in OLP remains unclear. The aim of the present study was to demonstrate the anti-inflammatory role of IL-37 in OLP.</p><p><strong>Materials and methods: </strong>Tissue, plasma, and saliva samples were collected from patients with OLP. Immunohistochemical (IHC) staining was performed on tissue sections for histological analysis. Expression levels of IL-37 in plasma and saliva were quantified using enzyme-linked immunosorbent assay (ELISA). Jurkat cells were given a human recombinant IL-37 protein pretreatment and analysed for their ability to proliferate. Through the use of RT-qPCR and immunofluorescence, the expression of glycolytic mammalian target of rapamycin (mTOR) -related genes and proteins in T cells was identified. The migration rate of HOK cells was measured in the co-culture system using the wound healing test, and the T cell apoptosis rate was determined using flow cytometry.</p><p><strong>Results: </strong>[1] ELISA analysis revealed no significant differences in salivary IL-37 levels between groups; however, plasma IL-37 levels were significantly elevated in OLP patients compared with controls (p<0.05). IHC staining of tissue samples from OLP patients revealed that IL-37 was down-regulated in the epithelial layer [2]. The effect of IL-37 on T cells alone could promote cell proliferation in the resting state and inhibit cell proliferation in the activated state, both of which could be reversed by MHY 1485, with statistically significant differences(P<0.05). Immunofluorescence showed that mTOR phosphorylation and lactate dehydrogenase A (LDHA) expression were down-regulated in the activated T cells by IL-37, with statistically significant differences(P<0.05). The results of the lactate assay suggested that IL-37 caused a decrease in total LDH release and down-regulation of glycolysis levels in T cells [3]. In the in vitro co-culture, flow cytometry results suggested that IL-37 up-regulated the apoptosis level of activated T cells, and cell scratch assay showed that IL-37 increased the migration level of HOK cells and the difference was statistically significant(P<0.05).</p><p><strong>Conclusions: </strong>IL-37 was abnormally expressed in OLP and inhibited the activities of mTOR and LDHA in Jurkat cells, thereby inhibiting the conversion of pyruvate to lactate, the last link in aerobic glycolysis. IL-37 showed inhibition of the proliferative activation capacity of Jurkat cells in the co-culture system as well as increased cell viability in HOK, suggesting that IL-37 may play a protective role in OLP.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102511"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF CHANGES IN PERI-IMPLANT BONE ARCHITECTURE AT DIFFERENT STAGES OF IMPLANT TREATMENT WITH FRACTAL ANALYSİS.","authors":"Damla Torul, Muhammed Furkan Yilmaz, Zerrin Ünal Erzurumlu, Mehmet Melih Omezli","doi":"10.1016/j.jormas.2025.102508","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102508","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the changes in the trabecular bone surrounding the implants after loading in patients with implant-supported prosthetic restorations using fractal analysis on panoramic radiographs.</p><p><strong>Method: </strong>Medical records of patients who underwent implants at Maxillofacial Surgery Clinic of Ordu University between January 2017 and October 2023 were retrospectively reviewed. Demographic data and characteristics of the implants were recorded. Bone quality in the mesial, distal and apical regions of the implants was evaluated by the box counting method using fractal analysis (FA) on panoramic radiographs taken postoperatively (T0), before loading (T1) and after loading (T2).</p><p><strong>Result: </strong>A total of 56 implants of 14 patients (7 females, 7 males) with a mean age of 54.64 ± 11.20 were included. When the fractal dimension (FD) values ​​measured for different regions of the implants were evaluated postoperatively, before loading and after loading, a statistically significant decrease was observed for all 3 regions (p<0.05).</p><p><strong>Conclusion: </strong>FD analysis using panoramic radiographs is an economical, promising, useful and non-invasive method for the evaluation of peri-implant bone changes at different periods in patients with implants. However, more clinical studies with larger sample sizes and longer follow-up periods are needed.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102508"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there predictive factors of complications of surgery for benign orbital tumors? A systematic review.","authors":"Marie Béret, Mathilde De Massary, Romain Nicot","doi":"10.1016/j.jormas.2025.102507","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102507","url":null,"abstract":"<p><strong>Introduction: </strong>Benign tumors account for 64-68 % of orbital tumors, with a wide variety of etiologies. The indication for surgical resection of a benign tumor is not systematic and depends mainly on the functional and esthetic clinical consequences. Surgical management presents risk of serious complications which can lead to major functional disorders and even blindness. The aim of this review is to identify the potential predictive factors of complications in benign orbital tumor surgery and assist therapeutic decision-making.</p><p><strong>Material and methods: </strong>A systematic review was performed, by searching on PubMed for articles published from January 2000 to July 2023 on surgical management in benign intraorbital tumors and their complications.</p><p><strong>Results: </strong>Of the 231 studies identified, 15 studies were included with 331 patients, including 183 cavernous hemangiomas, 52 dermoid cysts and 32 schwannomas. The main initial symptoms were exophthalmos or proptosis (83.3 %), decreased vision (21.9 %), and diplopia (11.6 %). 169 intraconal tumors, 50 extraconal tumors and two both intra and extraconal tumors were reported. Most of the studies reported a transconjunctival or transpalpebral approach (72.2 %). The included studies described 87 postoperative complications: severe postoperative visual deterioration (SPVD) (1.2 %), enophthalmos, transient diplopia, and ptosis.</p><p><strong>Discussion: </strong>This risk of SPVD seems increased in schwannomas and intraconal tumors, especially those close to the orbital apex. The intraconal location is also a risk factor for other complications (diplopia, enophthalmos, ptosis). Nevertheless, it cannot be concluded on the role of the surgical approach on the risk of complications.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102507"},"PeriodicalIF":2.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor: artificial intelligence in face transplantation: a promising tool for objectivity, with cautions on scope and scalability.","authors":"Parth Aphale, Shashank Dokania, Himanshu Shekhar","doi":"10.1016/j.jormas.2025.102506","DOIUrl":"10.1016/j.jormas.2025.102506","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102506"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the diagnostic value of preoperative blood indicators NLR, PLR and AAR in cervical lymph node metastasis of head and neck squamous cell carcinoma.","authors":"Ningchang Zhu, Jin Yang, Jun Sun, Yingying Jiang, Jiwei Zheng","doi":"10.1016/j.jormas.2025.102504","DOIUrl":"10.1016/j.jormas.2025.102504","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the clinical significance of preoperative blood test indicators in diagnosing cervical lymph node metastasis in patients with head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>A total of 97 HNSCC patients who underwent surgical treatment at the Affiliated Hospital of Xuzhou Medical University between October 2023 and January 2025 were included in the study. Based on postoperative pathological results, the patients were categorized into two groups: those with cervical lymph node metastasis and those without. Preoperative blood routine examination indicators, including neutrophils, platelets, and lymphocytes, as well as biochemical examination indicators such as aspartate aminotransferase and albumin, were collected. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-albumin ratio (AAR) were calculated. The diagnostic value of preoperative NLR, PLR and AAR for cervical lymph node metastasis in HNSCC patients was subsequently analyzed.</p><p><strong>Results: </strong>The NLR and AAR values in the cervical lymph node metastasis group were significantly higher than those in the non-cervical lymph node metastasis group. The optimal cut-off values and areas under the curve for NLR and AAR in diagnosing cervical lymph node metastasis among patients with HNSCC were 0.687 and 0.682 for NLR, and 3.3433 and 0.6338 for AAR, respectively. Results from multivariate logistic regression analysis indicated that AAR may serve as a potential blood indicator for evaluating cervical lymph node metastasis in HNSCC patients.</p><p><strong>Conclusion: </strong>Preoperative NLR, PLR and AAR have significant clinical value for the initial screening and diagnosis of lymph node metastasis in HNSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102504"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone-remodeling-related gene expression in oral squamous cell carcinoma: impact on mandibular invasion and overall survival.","authors":"Érica Fernanda Patricio, Gustavo Davi Rabelo, Carlos Henrique Horst Bianchin, Claudia Malheiros Coutinho-Camillo, Luiz Paulo Kowalski, Clovis Antônio Lopes Pinto, Fabio Abreu Alves","doi":"10.1016/j.jormas.2025.102505","DOIUrl":"10.1016/j.jormas.2025.102505","url":null,"abstract":"<p><strong>Objectives: </strong>Bone invasion by oral squamous cell carcinoma (OSCC) activates the remodeling process with the participation of RANK/RANKL/OPG and Interleukin 6 (IL-6) genes. This study aimed to evaluate gene expressions of RANK, RANKL, OPG, and IL-6 in OSCC associated with mandibular invasion (MI) and to identify their influence on patients' overall survival (OS).</p><p><strong>Materials and methods: </strong>A cross-sectional study selected patients treated with mandibulectomy for OSCC in a reference center, resulting in two hundred and twenty individuals. Forty age-match patients with material for molecular analysis were included in the study to evaluate RANK, RANKL, OPG, and IL6 expression analysis, divided into 2 groups: MI (n = 20) and no invasion (NI, n = 20). Tumor mRNA expression of the selected genes was determined by real-time polymerase chain reaction (calibrated by endogenous GAPDH and a control pool of non-neoplastic RNA).</p><p><strong>Results: </strong>Gene expression analysis revealed 16 of 36 cases (44%) presenting downregulation for RANK; 28 of 37 samples (75%) with overexpression for RANKL; 19 of 35 samples (54%) with downregulation for IL-6; and 16 of 37 samples (43%) with normal expression for OPG. IL-6 expression was associated with MI, and all the genes were correlated with each other (p < 0.05). Multivariate Cox regression revealed an association of MI and perineural invasion with OS, and higher OS rate was associated with IL-6 downregulation (p = 0.053, 108.5 months).</p><p><strong>Conclusions: </strong>Mandibular invasion may impact overall survival and is associated with IL-6 tumor expression. Downregulation of IL-6 by malignant cells is associated with higher overall survival.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102505"},"PeriodicalIF":2.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}