Journal of Stomatology Oral and Maxillofacial Surgery最新文献

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Skeletal, dentoalveolar and soft tissue effects of different maxillary expansion appliances in cleft lip/palate patients: A systematic review and frequentist network meta-analysis.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-10 DOI: 10.1016/j.jormas.2025.102312
Maged S Alhammadi, Fady Fahim, Reem Hassan Kelani, Areej Ali Alsaeedi, Basmah Hakam Mahdi, Najah Alhashimi, Esam Halboub, Abeer A Almashraqi
{"title":"Skeletal, dentoalveolar and soft tissue effects of different maxillary expansion appliances in cleft lip/palate patients: A systematic review and frequentist network meta-analysis.","authors":"Maged S Alhammadi, Fady Fahim, Reem Hassan Kelani, Areej Ali Alsaeedi, Basmah Hakam Mahdi, Najah Alhashimi, Esam Halboub, Abeer A Almashraqi","doi":"10.1016/j.jormas.2025.102312","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102312","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the available evidence regarding the skeletal, dentoalveolar and soft tissue effects of different maxillary expansion appliances in cleft lip/palate patients.</p><p><strong>Methods: </strong>We assessed the effects of different maxillary expansion appliances on skeletal structure and dentoalveolar and soft tissue in cleft lip/palate patients. We searched the PubMed, Science Direct, Web of Science, Cochrane, and LILACS databases through September 2024; that investigation was augmented by a manual search. We focused on clinical trials, either retrospective or prospective trials. The outcomes of interest included skeletal, dentoalveolar, and soft tissue changes obtained from study models, cephalometric radiographs, or cone beam computed tomography.</p><p><strong>Results: </strong>Of the 430 screened articles, only six satisfied our eligibility criteria and were included in the quantitative synthesis. These articles exhibited a moderate overall risk of bias. None of the appliances conferred better forward skeletal maxillary movement than the hyrax. The iMini-M was the most effective appliance for increasing maxillary skeletal width (mean: 0.89 mm [range: 0.01-1.78 mm]), with the hyrax following closely behind. The Haas appliance exhibited the largest inter-molar distance (mean: 4.76 mm [range: 2.53-6.99 mm]), followed by the EDO, iMini-M and the hyrax. The fan-type appliance was the least effective at resisting maxillary premolar tipping (14.46° [2.60-26.32]), and the iMini-P was the most effective at reducing molar tipping (-3.54° [-6.06- -1.02]).</p><p><strong>Conclusions: </strong>Considering the limited and moderate risk of bias, the iMini-M was the most effective appliance at increasing maxillary skeletal width compared with the hyrax; the Haas achieved the largest inter-molar distance. The fan-type appliance excelled at resisting premolar tipping, and the iMini-P offered the best control for molar tipping.</p><p><strong>Registration: </strong>The protocol for this systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO, No.: CRD42023489536).</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102312"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ki67 as a proliferation marker: a study on odontogenic keratocysts and radicular cysts.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-10 DOI: 10.1016/j.jormas.2025.102313
Maurizio D'Amario, Tommaso Pizzolante, Claudio Magnacca, Ilaria Mariani, Mario Capogreco, Ettore Lupi
{"title":"Ki67 as a proliferation marker: a study on odontogenic keratocysts and radicular cysts.","authors":"Maurizio D'Amario, Tommaso Pizzolante, Claudio Magnacca, Ilaria Mariani, Mario Capogreco, Ettore Lupi","doi":"10.1016/j.jormas.2025.102313","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102313","url":null,"abstract":"<p><p>Ki67 as a proliferation marker plays a critical role in assessing cellular activity in various pathological tissues, including cystic lesions. Odontogenic keratocysts (OKCs) and radicular cysts (RCs) are two common types of jaw cysts that exhibit distinct biological behaviors, particularly in their proliferative patterns. OKCs are known for their aggressive nature and high recurrence rate, while RCs are typically less aggressive and exhibit lower recurrence risk. By evaluating the expression of Ki67, a nuclear protein linked to cell proliferation, researchers can gain valuable insights into the growth potential and recurrence tendencies of these cysts. The study involved analyzing 32 biopsy samples from patients with OKCs and RCs, using immunohistochemical techniques to assess Ki67 expression levels. These samples were surgically removed and prepared for histological examination, with Ki67-positive cells quantified in both basal and suprabasal layers of the cystic epithelium. The findings revealed that OKCs exhibited a higher concentration of Ki67-positive cells in the basal layers, while RCs showed proliferative activity in both basal and suprabasal layers. This differential pattern highlights the more aggressive proliferative behavior of OKCs. The statistical analysis confirmed significant differences in Ki67 expression between the two cyst types, underscoring the importance of this marker in differentiating OKCs from RCs. The confined expression of Ki67 in the basal layer of OKCs, as opposed to the broader distribution in RCs, suggests that OKCs have a higher proliferative potential, contributing to their increased recurrence rates.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102313"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An innovative corrective method: Reutilization of auricular fistula in microtia reconstruction.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-08 DOI: 10.1016/j.jormas.2025.102311
Yiwen Deng, Jianguo Chen, Ben Wang, Yanlong Yang, Xiaobo Yu, Haiyue Jiang
{"title":"An innovative corrective method: Reutilization of auricular fistula in microtia reconstruction.","authors":"Yiwen Deng, Jianguo Chen, Ben Wang, Yanlong Yang, Xiaobo Yu, Haiyue Jiang","doi":"10.1016/j.jormas.2025.102311","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102311","url":null,"abstract":"<p><strong>Background: </strong>Auricular fistulas, typically excised due to infection risk, consist of intact skin and soft tissue when uninfected. A large fistula cavity with sufficient tissue coverage over cartilage and no infection during stable periods may be viable for reuse. This article explores using non-infected fistulas as soft tissue sources for microtia reconstruction.</p><p><strong>Method: </strong>Between January 2020 and October 2023, a total of 24 patients diagnosed with concha-type microtia were enrolled in this retrospective study. The correction of ear deformities is achieved by utilizing tissue harvested from the ear fistulas.Summarize the characteristic information of auricular fistula and the information on postoperative complications of auricular fistula. The ear morphology data(ear length and ear width) collected pre- and post-surgery, along with the Visual Analog Scale (VAS) satisfaction scores and Aesthetic Outcomes Scale(AOS) ear aesthetic evaluations, were assessed for the patients.</p><p><strong>Results: </strong>The mean follow-up duration for this study was 13.1 months.All patients included in this study were diagnosed with concha-type microtia. The auricular fistula was situated in the upper region of the auricle and opened onto the skin surface. The skin tissue surrounding the auricular fistula was abundant, and cartilage was present within the structure of the fistula. Postoperative follow-up indicated the absence of infection, flap necrosis, or any abnormal secretions. The postoperative measurements of ear length, width, and the difference in ear length and width between the two sides were all significantly improved compared to the preoperative measurements. The average preoperative AOS score was 1.2±0.4, and the average postoperative AOS score was 3.6±0.4. The preoperative VAS satisfaction score was 2.1±0.6, and the postoperative VAS score significantly increased to 8.0±0.8.</p><p><strong>Conclusion: </strong>The larger preauricular fistula tissue in a stable, non-infected state can be used as a valuable skin source for microtia reconstruction. Utilizing auricular fistula tissue in concha-type microtia correction enhances the auricular aesthetics, reduces secondary local trauma, and improves patient satisfaction with the surgical outcome.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102311"},"PeriodicalIF":2.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of skeletal Class II adolescents with favorable facial attractiveness outcomes based on 3D photos after Twin-block treatment.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-07 DOI: 10.1016/j.jormas.2025.102310
Jieqiong Hu, Chunhong Wang, Qingyi Li
{"title":"Characteristics of skeletal Class II adolescents with favorable facial attractiveness outcomes based on 3D photos after Twin-block treatment.","authors":"Jieqiong Hu, Chunhong Wang, Qingyi Li","doi":"10.1016/j.jormas.2025.102310","DOIUrl":"10.1016/j.jormas.2025.102310","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the hard tissue and soft tissue characteristics related to favorable facial attractiveness outcomes of Class II Twin-block treatment to select suitable patients for this therapy.</p><p><strong>Material and methods: </strong>A total of 86 skeletal Class II patients who had undergone Twin-block treatment were included in this study. Post-treatment facial attractiveness was assessed by seven orthodontists using visual analog scale (VAS) scores based on 3D photographs. Patients were ranked according to their VAS scores, with the top 26 individuals classified as the favorable group and the bottom 26 as the unfavorable group. Soft tissue and hard tissue measurements were obtained from their 3D photos and lateral cephalograms, and intergroup comparisons were conducted using the independent t-test and Mann-Whitney test.</p><p><strong>Results: </strong>The favorable group exhibited significantly lower values for Co-pog, FH-MP, L1-APog, Li-H Line, and Total Convexity Angle before treatment, according to independent t-tests and Mann-Whitney tests. Conversely, the favorable group demonstrated significantly higher values for the Wits appraisal, Pog-NB, S-Go/N-Me, Si-H and Ch_R-Li-Ch_L were larger(P < 0.05).</p><p><strong>Conclusions: </strong>Patients with low divergent skeletal patterns, a well-developed chin, upright lower incisors, a flat lower lip, and a large amount of skeletal discrepancy between the maxillary and the mandibular are likelier to achieve favorable facial attractiveness outcomes following Twin-block treatment.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102310"},"PeriodicalIF":2.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Submental island flap reconstruction in oral cavity cancer patients with pathological level I lymph node metastasis: Flap site recurrence and survival analysis.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-06 DOI: 10.1016/j.jormas.2025.102309
Donyarat Ruenmarkkaew, Orapan Sangiamporn, Hanpon Klibngern, Tapanut Ariyanon, Weerachai Watcharatsiriyuth, Pichit Sittitrai
{"title":"Submental island flap reconstruction in oral cavity cancer patients with pathological level I lymph node metastasis: Flap site recurrence and survival analysis.","authors":"Donyarat Ruenmarkkaew, Orapan Sangiamporn, Hanpon Klibngern, Tapanut Ariyanon, Weerachai Watcharatsiriyuth, Pichit Sittitrai","doi":"10.1016/j.jormas.2025.102309","DOIUrl":"10.1016/j.jormas.2025.102309","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to determine flap site recurrence rate in oral squamous cell carcinoma patients who had undergone reconstruction with submental island flap, to evaluate factors affecting flap site recurrence, particularly pathological level I lymph node status, and assess survival outcomes.</p><p><strong>Methods: </strong>Fifty-six patients with squamous cell carcinoma of the oral cavity who underwent surgical resection and submental island flap reconstruction between October 2012 and February 2024 were enrolled onto the study. Tumor recurrence and survival outcomes were analyzed. A Kaplan-Meier estimate of locoregional recurrence-free survival (LRRFS), disease-specific survival (DSS), and overall survival (OS) was calculated. Factors affecting flap site recurrence and survival outcomes were assessed.</p><p><strong>Results: </strong>Most patients (78.57 %) were in the advanced stage (stage III-IV), and 21.43 % had pathological level I lymph node metastasis. Flap site recurrence rate was observed in 5.36 % of cases, without any identifiable factors predicting the recurrence, including pathological level I lymph node metastasis. The 5-year LRRFS, DSS, and OS rates were 60.28 %, 84.55 %, and 67.38 %, respectively. Positive resection margin, perineural invasion, and extranodal extension adversely affected LRRFS.</p><p><strong>Conclusions: </strong>Submental island flap reconstruction in selected oral squamous cell carcinoma patients is oncologically safe regarding low flap site recurrence rate, satisfactory survival outcomes, and pathological level I lymph node metastasis did not affect the flap site recurrence.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102309"},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D model construction and biomechanical analysis of temporomandibular joint disc perforation based on arthrography.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-04 DOI: 10.1016/j.jormas.2025.102308
Yichun Wang, Wentong Gao, Jie Lu, Xia Lan, Jie Xu
{"title":"3D model construction and biomechanical analysis of temporomandibular joint disc perforation based on arthrography.","authors":"Yichun Wang, Wentong Gao, Jie Lu, Xia Lan, Jie Xu","doi":"10.1016/j.jormas.2025.102308","DOIUrl":"10.1016/j.jormas.2025.102308","url":null,"abstract":"<p><strong>Objectives: </strong>Disc perforation (DP) is a severe type of temporomandibular joint (TMJ) disorder. Arthrography-assisted CBCT can visually detect the location and size of DPs. This study aims to use imaging modeling software to construct a three-dimensional (3D) visual model of DP, simulating its biomechanical impact on the TMJ to provide a scientific basis for diagnosis and treatment.</p><p><strong>Materials and methods: </strong>TMJ imaging data were obtained through arthrography and CBCT scans. Imaging modeling software was used to reconstruct and measure the DICOM files in 3D. The model was imported into biomechanical analysis software to simulate the static occlusal state of the mandibular muscles on the TMJ. The effects of DP on the mechanical properties of the TMJ were assessed via von Mises stress and total deformation analysis.</p><p><strong>Results: </strong>(1) The maximum von Mises stress (MVMS) on the affected side of the disc was significantly greater than that on the unaffected side. This stress was negatively correlated with the height of the condylar head and positively correlated with the perforation volume. (2) The maximum total deformation (MTD) of the affected side's disc was significantly greater and negatively correlated with the condylar head height. (3) The MVMS of the condyle was markedly greater on the affected side than on the unaffected side.</p><p><strong>Conclusion: </strong>(1) DPs may increase stress on bilateral TMJs, with the affected side experiencing significantly greater stress. (2) A larger perforation volume can result in greater stress on the affected side's disc. (3) The height of the affected condylar head can have an adverse effect on the stress and deformation of bilateral TMJs.</p><p><strong>Clinical relevance: </strong>TMJ arthrography can assist clinicians in accurately determining the location, morphology, and size of the disc perforation, enabling early diagnosis and intervention to prevent further enlargement. Additionally, the restoration and protection of the condylar head height contribute to maintaining the stability of the intra-articular stresses within the TMJ.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102308"},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaction of third molars and localized cancer of the oral cavity: A simple occasional finding? A retrospective case series and literature review.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-03-03 DOI: 10.1016/j.jormas.2025.102307
Zotti M, Bussani R, Maglione M
{"title":"Impaction of third molars and localized cancer of the oral cavity: A simple occasional finding? A retrospective case series and literature review.","authors":"Zotti M, Bussani R, Maglione M","doi":"10.1016/j.jormas.2025.102307","DOIUrl":"10.1016/j.jormas.2025.102307","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to analyze, through a literature review and the description of four clinical cases, whether prolonged tooth impaction may represent a trigger for the onset of oral carcinoma.</p><p><strong>Materials e methods: </strong>In this report, four cases of patients needing the extraction of third molars in complete mucosal or bone impaction are described, which, due to the presence of an unusual radiographic and/or clinical aspect, were found to represent cases of oral carcinomas on histologic analysis. Patients were then referred to the ENT department for further care. A review of the literature has been performed as well.</p><p><strong>Results: </strong>Literature analysis revealed the presence of only few case reports on the topic, suggesting therefore a lack of evidence on the correlation between tooth impaction and the onset of oral carcinomas.</p><p><strong>Conclusions: </strong>Further studies are needed in order to give valid hypotheses. The concept of inflammation, that is at the base of oral carcinogenesis mechanism and tooth-related pathologies, such as pericoronitis, may be a common substrate to link these two phenomena.</p><p><strong>Clinical relevance: </strong>A thorough analysis of the radiographic and clinical signs is strongly recommended prior and during surgical procedures, such as tooth extraction.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102307"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of accuracy between two different drill designs for static computer-assisted implant surgery: An in vitro study.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-02-23 DOI: 10.1016/j.jormas.2025.102303
Mengyun Mao, Ting Wei, Mingxing Fan, Haisong Pan, Fudong Zhu
{"title":"Comparison of accuracy between two different drill designs for static computer-assisted implant surgery: An in vitro study.","authors":"Mengyun Mao, Ting Wei, Mingxing Fan, Haisong Pan, Fudong Zhu","doi":"10.1016/j.jormas.2025.102303","DOIUrl":"10.1016/j.jormas.2025.102303","url":null,"abstract":"<p><strong>Background: </strong>Although several different design methods have been proposed, limited research is available regarding how design features impact accuracy and performance. The purpose of this study was to compare the accuracy of implant site location between two different drilling systems for static computer-assisted implant surgery (sCAIS) in vitro study, each featuring a unique drill stabilization configuration.</p><p><strong>Materials and methods: </strong>Sixty models were fabricated simulating a patient with maxillary partial tooth missing. Each model included two single-tooth gap (STG) situations; two extraction socket sites; and a distal extension situation. Experimental models were categorized into two distinct groups, group A: a sleeve-in-sleeve system with a metal sleeve embedded in the surgical guide; group B: an integrated sleeve-on-drill system without a metal sleeve. The deviations in shoulder, tip, depth, and angular were measured. Date were analyzed using the Scheirer-Ray-Hare test (P ≤ 0.05).</p><p><strong>Results: </strong>The deviation of shoulder, tip and angular in group B were significantly lower than group A. When using an integrated sleeve-on-drill system, the remaining deviation values in extraction sockets were significantly higher than those in the STG situation and the distal extension situation, with the exception of depth deviation. However, there is no significant difference between STG situation and distal extension situation.</p><p><strong>Conclusion: </strong>In comparison to the sleeve-in-sleeve system with a metal sleeve in the surgical guide, the accuracy of an integrated sleeve-on-drill system without a metal sleeve was higher. The accuracy of implantation in extracted sockets was significantly lower than that in healing sites.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102303"},"PeriodicalIF":2.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic brain injury in patients with facial fracture - A challenge for the clinician?
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-02-21 DOI: 10.1016/j.jormas.2025.102302
L Kokko, T Puolakkainen, H Thorén, A Piippo-Karjalainen, A L Suominen, J Snäll
{"title":"Traumatic brain injury in patients with facial fracture - A challenge for the clinician?","authors":"L Kokko, T Puolakkainen, H Thorén, A Piippo-Karjalainen, A L Suominen, J Snäll","doi":"10.1016/j.jormas.2025.102302","DOIUrl":"10.1016/j.jormas.2025.102302","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the occurrence and clinical predictors for missed traumatic brain injury (TBI) diagnosis at primary evaluation in facial fracture patients. The specific aim was to compare the risk between adults and elderly patients.</p><p><strong>Materials and methods: </strong>A retrospective study was performed, and data were collected from medical records. All adult facial fracture patients with associated TBI and a primary Glasgow Coma Scale score of 13 or more diagnosed and treated between 2013 and 2018 were included. The elderly group comprised patients aged at least 65 years at the time of injury.</p><p><strong>Results: </strong>Altogether 253 patients with facial fracture and associated TBI were assessed. In 7.1 % of the cases, the diagnosis of TBI was missed in primary evaluation and thus delayed. When the different age groups were compared, the elderly had a 2.8-fold risk of missed TBI diagnosis (95 % CI 1.1-7.2, p=.0349).</p><p><strong>Conclusions: </strong>Facial fracture patients are at significant risk of the diagnosis of associated TBI being missed at primary evaluation. Especially elderly patients with other than high-energy trauma mechanism, such as falling on ground level, are at risk of missed TBI diagnosis. Thus, patients with facial fracture should be carefully evaluated to exclude potential TBI. Assessment should occur in trauma centres where multiprofessional evaluation of these patients is routine.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102302"},"PeriodicalIF":2.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CircPVT1 promotes periodontitis progression by regulating miR-24-3p/HIF1AN pathway.
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-02-20 DOI: 10.1016/j.jormas.2024.102198
Yuting Bian, Jingwen Yu, Yang Liu, Yahong Shi, Yujiao Hou, Xin Liu
{"title":"CircPVT1 promotes periodontitis progression by regulating miR-24-3p/HIF1AN pathway.","authors":"Yuting Bian, Jingwen Yu, Yang Liu, Yahong Shi, Yujiao Hou, Xin Liu","doi":"10.1016/j.jormas.2024.102198","DOIUrl":"10.1016/j.jormas.2024.102198","url":null,"abstract":"<p><strong>Purpose and background: </strong>Periodontitis is a chronic inflammatory oral disease affecting half of the adult population. Circular RNA plays a critical role in periodontitis. CircPVT1(hsa_circ_0085536) was abundant in periodontitis tissues and cells but its mechanism are still unclear. We aim to explore the role of circPVT1 in periodontitis and elucidate how circPVT1 acts.</p><p><strong>Methods: </strong>Gingival tissues from patients with periodontitis(n=20) and health participants(n=20) were collected and the expression of circPVT1 was measured by realtime quantitative PCR(RT-qPCR). Cell model for periodontitis was performed by PDLCs treated lipopolysaccharide(LPS). Cell Counting Kit-8(CCK-8), flow cytometry, enzyme-linked immunoabsorbent assay (ELISA), ALP staining and Alizarin red staining were conducted to detect cell viability, apoptosis, inflammatory and oxidative stress factors and osteogenic differentiation. The targeting microRNA(miRNA)/mRNA axis of circPVT1 was predicted and screened.</p><p><strong>Results: </strong>circPVT1 was upregulated in the gingival tissues of patients with periodontitis. Silencing of circPVT1 inhibited cell viability, decreased inflammatory factors(IL-1β, TNF-α, IL-6) and oxidative stress factors, activated NRF-2 and HO-1 expression and promoted apoptosis and osteoclast differentiation in PDLCs after treated LPS. However, these effects were reversed by transfected miR-24-3p inhibitor and overexpressed of hypoxia-inducible factor 1 subunit alpha inhibitor(HIF1AN) in PDLCs.</p><p><strong>Conclusion: </strong>circPVT1 promotes the progression of periodontitis by modulating NRF-2/HO-1 pathway via the miR-24-3p/HIF1AN axis.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102198"},"PeriodicalIF":2.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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