{"title":"Letter to editor: artificial intelligence in face transplantation: a promising tool for objectivity, with cautions on scope and scalability.","authors":"Parth Aphale, Shashank Dokania, Himanshu Shekhar","doi":"10.1016/j.jormas.2025.102506","DOIUrl":"10.1016/j.jormas.2025.102506","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102506"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ningchang Zhu, Jin Yang, Jun Sun, Yingying Jiang, Jiwei Zheng
{"title":"Analysis of the diagnostic value of preoperative blood indicators NLR, PLR and AAR in cervical lymph node metastasis of head and neck squamous cell carcinoma.","authors":"Ningchang Zhu, Jin Yang, Jun Sun, Yingying Jiang, Jiwei Zheng","doi":"10.1016/j.jormas.2025.102504","DOIUrl":"10.1016/j.jormas.2025.102504","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the clinical significance of preoperative blood test indicators in diagnosing cervical lymph node metastasis in patients with head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>A total of 97 HNSCC patients who underwent surgical treatment at the Affiliated Hospital of Xuzhou Medical University between October 2023 and January 2025 were included in the study. Based on postoperative pathological results, the patients were categorized into two groups: those with cervical lymph node metastasis and those without. Preoperative blood routine examination indicators, including neutrophils, platelets, and lymphocytes, as well as biochemical examination indicators such as aspartate aminotransferase and albumin, were collected. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-albumin ratio (AAR) were calculated. The diagnostic value of preoperative NLR, PLR and AAR for cervical lymph node metastasis in HNSCC patients was subsequently analyzed.</p><p><strong>Results: </strong>The NLR and AAR values in the cervical lymph node metastasis group were significantly higher than those in the non-cervical lymph node metastasis group. The optimal cut-off values and areas under the curve for NLR and AAR in diagnosing cervical lymph node metastasis among patients with HNSCC were 0.687 and 0.682 for NLR, and 3.3433 and 0.6338 for AAR, respectively. Results from multivariate logistic regression analysis indicated that AAR may serve as a potential blood indicator for evaluating cervical lymph node metastasis in HNSCC patients.</p><p><strong>Conclusion: </strong>Preoperative NLR, PLR and AAR have significant clinical value for the initial screening and diagnosis of lymph node metastasis in HNSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102504"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bone-Remodeling-Related Gene Expression in Oral Squamous Cell Carcinoma: Impact on Mandibular Invasion and Overall Survival.","authors":"Érica Fernanda Patricio, Gustavo Davi Rabelo, Carlos Henrique Horst Bianchin, Claudia Malheiros Coutinho-Camillo, Luiz Paulo Kowalski, Clovis Antônio Lopes Pinto, Fabio Abreu Alves","doi":"10.1016/j.jormas.2025.102505","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102505","url":null,"abstract":"<p><strong>Objectives: </strong>Bone invasion by oral squamous cell carcinoma (OSCC) activates the remodeling process with the participation of RANK/RANKL/OPG and Interleukin 6 (IL-6) genes. This study aimed to evaluate gene expressions of RANK, RANKL, OPG, and IL-6 in OSCC associated with mandibular invasion (MI) and to identify their influence on patients' overall survival (OS).</p><p><strong>Materials and methods: </strong>A cross-sectional study selected patients treated with mandibulectomy for OSCC in a reference center, resulting in two hundred and twenty individuals. Forty age-match patients with material for molecular analysis were included in the study to evaluate RANK, RANKL, OPG, and IL6 expression analysis, divided into 2 groups: MI (n=20) and no invasion (NI, n=20). Tumor mRNA expression of the selected genes was determined by real-time polymerase chain reaction (calibrated by endogenous GAPDH and a control pool of non-neoplastic RNA).</p><p><strong>Results: </strong>Gene expression analysis revealed 16 of 36 cases (44%) presenting downregulation for RANK; 28 of 37 samples (75%) with overexpression for RANKL; 19 of 35 samples (54%) with downregulation for IL-6; and 16 of 37 samples (43%) with normal expression for OPG. IL-6 expression was associated with MI, and all the genes were correlated with each other (p<0.05). Multivariate Cox regression revealed an association of MI and perineural invasion with OS, and higher OS rate was associated with IL-6 downregulation (p=0.053, 108.5 months).</p><p><strong>Conclusions: </strong>Mandibular invasion may impact overall survival and is associated with IL-6 tumor expression. Downregulation of IL-6 by malignant cells is associated with higher overall survival.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102505"},"PeriodicalIF":2.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Maly, Renaat Coopman, Hugo De Bruyn, Luc Van Doorne
{"title":"Predictive value of Periotest® assessment for failure of Mini Dental Implants supporting maxillary overdentures: a pilot study.","authors":"Thomas Maly, Renaat Coopman, Hugo De Bruyn, Luc Van Doorne","doi":"10.1016/j.jormas.2025.102502","DOIUrl":"10.1016/j.jormas.2025.102502","url":null,"abstract":"<p><strong>Objective: </strong>This prospective cohort study assesses the long-term (5 years) clinical outcome of mini dental implants (MDIs) supporting maxillary overdentures with Periotest® and explores the applicability of Periotest® values (PTV) to predict implant failure.</p><p><strong>Materials and methods: </strong>Included patients were edentulous in the maxilla, dissatisfied with their conventional dentures, and reluctant to undergo augmentation procedures. Per patient, 5 to 8 MDIs (ILZ, Southern Implants Inc., Irene, South Africa) were placed flaplessly. Provisional loading occurred after one week, functional loading after 4-6 months. Periodical assessment up to 5 years after placement was performed with Periotest® (Gulden Medizintechnik, Bensheim an der Bergstraβe, Germany). Statistical analysis compared subgroups nonparametrically, while Pearson correlation analyzed covariance of continuous variables. Linear regression analysis identified predictors for MDI failure. Significance level was set at p < 0.05.</p><p><strong>Results: </strong>Placement of 204 MDIs in 31 patients resulted in a 5 years cumulative failure rate of 23.2%. Successful implants yielded a PTV of 5.87 (SD 5.717) at baseline and 5.37 (SD 6.294) at 5 years respectively (p = 0.336). Failed implants demonstrated elevated last Periotest® measurement 3 months (21.55; SD 8.694; p = 0.007) and 12 months (18.86; SD 10.612; p = 0.007) before failure. A regression analysis with survival time as the dependent factor, identified the last available PTV as a significant predictor of implant failure (p < 0.001; R²=0.451).</p><p><strong>Conclusion: </strong>MDIs are a viable treatment option for supporting maxillary overdentures in last-resort cases with severe atrophy. Periotest® measurements aid monitoring long-term stability in MDIs and attribute to prediction of implant failure.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102502"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Relationship between insertion torque and ISQ of 600 implants placed in soft bone with different surgical techniques.\" IN VITRO STUDY.","authors":"Clarisse Brunel, Sonnica Galan-Gil, Celia Carrillo Garcia, Sonia Sánchez Carilla","doi":"10.1016/j.jormas.2025.102500","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102500","url":null,"abstract":"<p><strong>Background: </strong>Primary stability plays a crucial role in implant success as it is influenced by bone characteristics, surgical techniques and implant design. The aim of this study was to determine the correlation between implant stability quotient (ISQ) and insertion torque (IT) in dental implants.</p><p><strong>Materials and methods: </strong>An in vitro, cross-sectional, analytical study was carried out. For the study, polyurethane blocks simulating type IV bone were used, in which dental implants from 5 different commercial brands were placed. 600 osteotomies were performed, divided into three groups of 200 samples each. The 3 groups corresponded to three different surgical techniques: underdrilling, osteotomes, and osseodensification. Implants of the five brands were equally distributed in each group. ISQ and IT were measured.</p><p><strong>Results: </strong>An inverse relationship was observed between IT and ISQ, indicating that higher insertion torque was associated with lower ISQ values. However, this relationship was weak. Furthermore, there was no statistically significant difference that the ISQ values of the three groups of surgical techniques were significantly different. Regarding the analysis of the macro-design of the implants, it was found that implants with conical design, and threads with variable depths had a significantly higher ISQ than those with hybrid design and threads with constant depths.</p><p><strong>Conclusions: </strong>The correlation between IT and ISQ is inverse, but the relationship is weak; is due to the fact that ISQ and IT measure different aspects of stability, so are considered complementary parameters for assessing the primary stability of the implant. The surgical placement technique has no significant impact on primary stability, but the type of implant macro-design has a significant influence on it.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102500"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao
{"title":"Survival outcomes and prognostic factors in pediatric head and neck squamous cell carcinoma: A population-based study.","authors":"Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao","doi":"10.1016/j.jormas.2025.102501","DOIUrl":"10.1016/j.jormas.2025.102501","url":null,"abstract":"<p><strong>Objective: </strong>This population-based cohort study aimed to offer a thorough analysis of head and neck squamous cell carcinoma (HNSCC) in pediatric and adolescent populations.</p><p><strong>Methods: </strong>We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) program, covering the period from 2000 to 2020. We included cases of primary HNSCC in patients aged 0-19 years with documented causes of death. Survival analysis was conducted using Kaplan-Meier methods, and differences in survival rates were assessed with the log-rank test. Cox proportional-hazards regression was applied to identify factors influencing overall survival (OS).</p><p><strong>Results: </strong>A total of 143 pediatric HNSCC cases were identified, with an average age of 15.4 years at diagnosis and a predominance of male patients (65 %). Tumor distribution was nearly equal between the oral cavity (46.8 %) and the nasopharynx (53.2 %). Nasopharyngeal HNSCC was associated with significantly better overall survival compared to oral cavity HNSCC (p = 0.017). Surgical treatment notably improved survival in oral cavity HNSCC cases (p = 0.022). Cox regression analysis revealed tumor site and chemotherapy as independent predictors of survival.</p><p><strong>Conclusions: </strong>Pediatric HNSCC is a rare condition with diverse survival outcomes based on tumor location. Our study highlights the effectiveness of surgical treatment for oral cavity HNSCC and underscores the importance of tumor site in prognostic assessments for overall survival.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102501"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When permanent lip makeup masks vascular occlusion, leading to intra-buccal and skin necrosis: Complications of full-face rejuvenation.","authors":"M Majzoub, V Moris","doi":"10.1016/j.jormas.2025.102503","DOIUrl":"10.1016/j.jormas.2025.102503","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102503"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maxime Lavigogne, Jordan Bouchet, Benjamin Pomes, Gaoussou Toure
{"title":"The zygomatic implant perforated flap in the reconstruction and early rehabilitation of low-level maxillectomies: A technical note.","authors":"Maxime Lavigogne, Jordan Bouchet, Benjamin Pomes, Gaoussou Toure","doi":"10.1016/j.jormas.2025.102498","DOIUrl":"10.1016/j.jormas.2025.102498","url":null,"abstract":"<p><p>The \"Zygomatic Implant Perforated Flap\" (ZIP flap) technique, first described by Butterworth in 2017, combines the closure of bucco-sinusal or bucco-nasal communications using a fasciocutaneous free flap with early implant-based prosthetic rehabilitation via zygomatic implants that perforate the flap. This approach enables rapid dental rehabilitation within weeks of tumor resection, promoting early recovery of oral function. We present the case of a 49-year-old male who underwent delayed ZIP flap reconstruction one year after maxillectomy and radiotherapy. Four zygomatic implants were placed using a surgical guide, followed by inset of a radial forearm free flap perforated over each implant emergence. A prefabricated transitional prosthesis was immediately screwed onto the implants. This technical note highlights the advantages of the ZIP flap in reconstructing Brown Class II maxillectomy defects, offering reduced rehabilitation time, improved prosthesis retention, and enhanced functional and psychological outcomes.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102498"},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of 3D impaction models and surgical plates in mesiodens.","authors":"Ryosuke Yoshizaki, Arihiro Nakamura, Hiroki Inoue, Atsushi Nakayama, Yuki Aoki, Eriko Nomura, Shunsuke Kako, Ken Miyazawa, Atsushi Abe, Tetsushi Oguma","doi":"10.1016/j.jormas.2025.102499","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102499","url":null,"abstract":"<p><p>Supernumerary teeth are often extracted as they cause delayed eruption of permanent teeth, malocclusion, and infection. To avoid complications, such as damage to the permanent tooth embryo and adjacent tooth root, and errant extraction, we utilized digital technology to create a three-dimensional (3D) impaction model of the tooth and a surgical plate based on computed tomography (CT) data and intraoral scans. This study reports three cases of mesiodens extraction under general anesthesia, applying a 3D impaction model and a surgical plate. All patients were male and aged between 6 to 27 years. The extraction approach was palatal in two cases and labial in one; bone cutting was performed using ultrasonic cutting instruments. Mean operative time was 57 min, and bleeding was minimal with no intra- or post-operative complications. Development of 3D impaction models and surgical plates using digital technology and case reports are needed in future.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102499"},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Debortoli, O Rios, S Latreche, F Afota, R Castro, C Savoldelli
{"title":"Maxillary Rehabilitation using subperiosteal implants associated with a Lefort 1 Osteotomy : a technical note.","authors":"C Debortoli, O Rios, S Latreche, F Afota, R Castro, C Savoldelli","doi":"10.1016/j.jormas.2025.102497","DOIUrl":"10.1016/j.jormas.2025.102497","url":null,"abstract":"<p><strong>Introduction: </strong>With the advent of digital workflows, subperiosteal implants have experienced a resurgence. They offer a valuable solution for rehabilitating patients with severe maxillary atrophy. However, in cases involving an initial skeletal discrepancy, prosthetic compensation is often required. This report aims to minimize such compensation by combining subperiosteal implants with a Le Fort I osteotomy.</p><p><strong>Technical note: </strong>Le Fort I osteotomy and subperiosteal implant placement were performed under general anesthesia. The implants were osteosynthesized following the osteotomy, while maintaining proper occlusion through guided positioning.</p><p><strong>Conclusion: </strong>This technique requires significant surgical expertise. The addition of a Le Fort I osteotomy reduces prosthetic compensation and effectively addresses the sagittal skeletal discrepancy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102497"},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}