Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Spontaneous Bone Regeneration of Post-Enucleation Defects of Osteolytic Lesions in the Mandible: A Digital Three-Dimensional Morphometric Analysis.","authors":"Pierluigi Mariani, Diana Russo, Lucio Lo Russo, Gabriele Liberti, Dardo Menditti, Luigi Laino","doi":"10.1016/j.jormas.2025.102411","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102411","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous bone regeneration after enucleation of osteolytic lesions in the mandible is crucial for healing bone defects. understanding when spontaneous bone regeneration suffices can help clinicians make informed decisions.</p><p><strong>Purpose: </strong>This study aimed to assess the extent of spontaneous bone regeneration in post-enucleation mandibular osteolytic lesion cavities using a 3D digital approach. Secondary objectives included identifying factors like age, lesion size, and anatomical site that could influence regeneration.</p><p><strong>Study design: </strong>The study included patients aged 18-65 years who underwent enucleation of an osteolytic mandibular lesion, with available pre-treatment and follow-up CBCT scans.</p><p><strong>Main outcomes: </strong>The primary outcome was the percentage of regenerated bone volume (%RBV), calculated using 3D-volumetric analysis. Secondary outcomes included age, gender, lesion volume and site, number of extracted teeth, bone-wall involvement, and follow-up.</p><p><strong>Results: </strong>The study involved 20 patients, with a mean age of 40.1 ± 16.06 years. %RBV ranged from 32% to 97%, with a mean of 66.95%. Significant predictors of regeneration included age, lesion site, and bone wall involvement.</p><p><strong>Conclusions: </strong>Spontaneous bone regeneration can often achieve significant healing even in large defects; understanding the factors influencing this process can guide treatment strategies and improve clinical outcomes.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102411"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of nasal tip using auricular cartilage to prevent depression following midline partial maxillectomy: A report of two cases.","authors":"Akinori Takeshita, Kazuhide Matsunaga, Yoshihiro Morita, Yuka Matsumiya, Masashi Okumura, Himeka Sakake, Narikazu Uzawa","doi":"10.1016/j.jormas.2025.102417","DOIUrl":"10.1016/j.jormas.2025.102417","url":null,"abstract":"<p><p>Midline partial maxillectomy involving anterior nasal spine and septum in patients with maxillary carcinoma can result in postoperative depression of the nasal column and apex, even when a maxillary prosthesis is used. We encountered patients who developed significant nasal column and tip depression following surgery. To address this issue, we performed nasal septum reconstruction using auricular cartilage. Auricular cartilage was harvested bilaterally, and two grafts were stacked and transplanted into the nasal septal defect. After surgery, the transplanted cartilage became covered with mucosa, and the nasal column and apex were maintained without any signs of depression. This reconstruction technique represents a useful method for preventing nasal deformity in patients undergoing midline partial maxillectomy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102417"},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachytherapy efficacy and safety in the treatment of primitive tongue carcinomas: experience from the Oscar Lambret Center.","authors":"Aziliz Dreszer, Cécile Olejnik, Estelle Aymes, Maël Barthoulot, Xavier Liem, Abel Cordoba","doi":"10.1016/j.jormas.2025.102416","DOIUrl":"10.1016/j.jormas.2025.102416","url":null,"abstract":"<p><strong>Purpose: </strong>The study aim was to evaluate efficacy and safety of brachytherapy for the treatment of early-stage tongue carcinoma and identify factors associated with the risk of local recurrence. The interest is to discuss the contribution of brachytherapy among therapeutics of tongue tumors treatments.</p><p><strong>Patients and methods: </strong>Between January 2010 and December 2020, 55 patients with T1T2N0 tongue primitive squamous cell carcinomas were treated with interstitial low-dose-rate, pulsed-dose-rate, or high-dose-rate brachytherapy, with or without neck dissection, at the Centre Oscar Lambret of Lille. The primary objective was to evaluate the efficacy of brachytherapy in terms of local recurrence-free survival (LRFS). The secondary objectives were to estimate regional recurrence-free survival (RRFS), overall survival (OS), and to describe toxicities of brachytherapy.</p><p><strong>Results: </strong>Local recurrence-free survival (LRFS) rates at 1-year, 3-years, and 5-years follow-up were 90.9 %, 62.9 %, and 49.4 %, respectively. The cumulative incidences of local recurrence at 1-year, 3-years, and 5-years follow-up were 1.8 %, 10.2 %, and 12.3 %, respectively; Overall survival (OS) rates at 1-year, 3-years, and 5-years follow-up were 90.9 %, 71.2 %, and 53.4 %, respectively, with a 95 % confidence interval (CI). We identified 14 (25.5 %) grade 3 complications and 10 (29.1 %) grade 2 complications. Age at diagnosis (p < 0.001), smoking (p = 0.018), and tumor stage (p = 0.009) were found to be significant prognostic factors (p < 0.05) for LRFS.</p><p><strong>Conclusion: </strong>Brachytherapy is a moderate effective treatment option for early-stage tongue carcinoma. Despite the frequent toxicities generated this approach offers several notable advantages, including preservation of oral anatomy and functions, ultimately leading to an improved quality of life for patients.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102416"},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AlphaFold: An Emerging Tool for Drug Development in Oral Cancer.","authors":"Lucas Alves da Mota Santana, Lara Góis Floresta, Rajiv Gandhi Gopalsamy, Bernardo Ferreira Brasileiro, Cleverson Luciano Trento, Lysandro Pinto Borges","doi":"10.1016/j.jormas.2025.102414","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102414","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102414"},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filler migration mimicking lymphatic malformation in the maxillary vestibular groove: Questioning the role of hyaluronic acid versus permanent fillers.","authors":"Dongpo Li, Meng Wang, Lin Wang, Yubo Wei, Shuangyi Wang","doi":"10.1016/j.jormas.2025.102413","DOIUrl":"10.1016/j.jormas.2025.102413","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102413"},"PeriodicalIF":2.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers and knowledge map of macrophage in wound healing: a scientometric and visualization analysis.","authors":"Chongqing Yu, Chi Xu, Tao Wang, Jie Xu","doi":"10.1016/j.jormas.2025.102410","DOIUrl":"10.1016/j.jormas.2025.102410","url":null,"abstract":"<p><strong>Background: </strong>The skin is a protective barrier against environmental elements. Given its position as the body's outermost layer, the skin is vulnerable to injury, often leading to what we commonly refer to as wounds. Wound healing presents a substantial and intricate challenge in both clinical practice and scientific investigation. Among the key players in wound healing, macrophages hold a central role as primary inflammatory cells. Therefore, this study aims to portray the knowledge landscape in the realm of macrophages in wound healing through bibliometric analysis.</p><p><strong>Methods: </strong>Publications concerning macrophages in wound healing were comprehensively searched and selected from the Web of Science Core Collection(WOSCC) database.</p><p><strong>Results: </strong>A total of 1998 publications from 71 countries/regions, focusing on macrophages in wound healing, were identified and published between 1987 and 2023. China and the USA ranked as the top two contributors in this field. Leading institutions included Shanghai Jiaotong University, the University System of OHIO, the University of California System, the University of Illinois System, and the University of Manchester. Chen L emerged as the most prolific author with the highest number of citations, while Werner S ranked in the top one in the average citations. Among journals, the Journal of Investigative Dermatology had the most publications, while Wound Repair and Regeneration was the most cited. Noteworthy keywords in this area encompass antibacterial, nanoparticles, hydrogel, and antioxidant. The research focus has shifted from traditional mechanisms of wound healing to the advanced application of biomaterials. Emerging hotspots in research center around biomaterials, with keywords like 'hydrogel,' 'nanoparticles,' 'inflammation,' 'macrophage polarization,' and 'antibacterial' gaining prominence.</p><p><strong>Conclusion: </strong>Collectively, hydrogel stands out as a promising treatment approach for wound healing. This study offers an extensive overview of research on macrophages in wound healing from 1987 to 2023, utilizing bibliometric analysis, providing readers with a valuable reference to steer future research endeavors.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102410"},"PeriodicalIF":2.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of a class III patient with maxillary retrognathia and amelogenesis imperfecta using a surgery-only orthognathic approach.","authors":"Sezai Çiftçi, Mehmet Sait Şimşek, Samet Özden","doi":"10.1016/j.jormas.2025.102409","DOIUrl":"10.1016/j.jormas.2025.102409","url":null,"abstract":"<p><p>Amelogenesis imperfecta (AI) is a rare disorder characterized by structural irregularities of enamel and may be associated with various oral-craniofacial features. The compromised surface of the teeth creates an unsuitable area for the application of orthodontic appliances. The aim of this study is to present the prosthetic rehabilitation of an 18-year-old male patient diagnosed with amelogenesis imperfecta and skeletal Class III malocclusion due to maxillary retrognathia, following a surgery-only approach (SOA) with virtually planned Le Fort I and bilateral sagittal split ramus osteotomies (BSSRO).</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102409"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel model for predicting prognosis in patients with metastatic major salivary gland carcinoma.","authors":"Shuyi Liu, Ziwen Wen, Haodong Li, Zhibao Geng, Shifeng Li, Xiaopeng Sun, Dan Bai, Yu Li","doi":"10.1016/j.jormas.2025.102412","DOIUrl":"10.1016/j.jormas.2025.102412","url":null,"abstract":"<p><strong>Background: </strong>Patients with metastatic major salivary gland carcinoma (SGCs) always end with a poor prognosis, and survival time is a major concern for clinicians and patients, but effective predictive tools are lacking in clinical practice.</p><p><strong>Methods: </strong>Clinical information on patients diagnosed with metastatic major SGCs was extracted from the SEER database. Cox analysis was applied to identify clinicopathological characteristics associated with patient overall survival (OS). A random survival forest (RSF) algorithm was used to establish an accurate prognostic prediction model for these patients.</p><p><strong>Results: </strong>Cox analysis revealed that age, T stage, N stage, pathology type, bone and liver metastasis, primary tumor surgery, chemotherapy, and radiotherapy were independent factors for OS among patients with metastatic major SGCs. Our RSF model has a C-index of 0.657 in the test set and 0.701 in the external validation set, and the area under the curve (AUC) values at 1, 3, and 5 years range from 0.715-0.802 in the test set and 0.655-0.918 in the external validation set. Patients were divided into high-risk and low-risk groups based on the risk score of the RSF model, and patients in the low-risk group had significantly better OS than those in the high-risk group, and chemotherapy did not benefit patients in the low-risk group.</p><p><strong>Conclusion: </strong>In this study, a prognostic prediction model was constructed for patients with metastatic major SGCs using RSF algorithm, and the validation results indicate that the model has the potential to be a useful tool for clinicians in predicting survival and designing individualized treatment.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102412"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of stromal mucin expression in oral submucous fibrosis and its progression to oral squamous cell carcinoma.","authors":"Sujitha A, Pratibha Ramani, Suvarna K Nair","doi":"10.1016/j.jormas.2025.102408","DOIUrl":"10.1016/j.jormas.2025.102408","url":null,"abstract":"<p><strong>Introduction: </strong>Oral potentially malignant conditions (OPMDs) are abnormalities in the oral mucosa linked to a higher chance of developing oral cancer. Oral submucous fibrosis (OSMF) is a chronic condition causing tissue fibrosis, collagen deposition, and scar tissue production. The highest prevalence of OSMF is reported in Southeast Asian countries, with areca nut consumption being a significant factor.</p><p><strong>Materials and methods: </strong>This retrospective study involved 20 histopathologically confirmed cases: 10 of oral submucous fibrosis (OSMF) and 10 of oral squamous cell carcinoma (OSCC) arising in the background of OSMF. Alcian blue staining was used to evaluate stromal mucin expression. The Pearson Chi-Square test assessed the relationship between mucin expression and disease progression.</p><p><strong>Results: </strong>A progressive increase in mucin expression was observed in OSMF-OSCC cases compared to OSMF. Alcian Blue staining revealed 35 % no expression and 15 % low expression in OSMF, while 35 % had low expression and 15 % had moderate expression in OSMF-OSCC cases. The chi-square test yielded a value of 13.3 (df = 2), with a corrected p-value of 0.003, indicating statistical significance.</p><p><strong>Conclusion: </strong>Alcian Blue staining suggests a trend of increasing mucin expression during malignant transformation. While not a definitive malignancy marker, it may serve as a useful adjunct in histopathological grading. Further studies with larger cohorts and standardized mucin quantification are recommended.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102408"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive surgically assisted miniscrew anchored rapid palatal expansion (sa-MARPE) technique: avoiding conventional horizontal maxillary osteotomies - a technical note.","authors":"Andrea Balercia, Giulio Cirignaco, Paolo Balercia","doi":"10.1016/j.jormas.2025.102415","DOIUrl":"10.1016/j.jormas.2025.102415","url":null,"abstract":"<p><p>In skeletally mature patients, transverse maxillary deficiency poses a significant challenge due to the rigidity of craniofacial sutures. This technical note describes a minimally invasive, surgically assisted MARPE (sa-MARPE) protocol designed to overcome these limitations while avoiding complete Le Fort I osteotomies. The technique involves three small mucosal incisions and limited piezosurgical osteotomies targeting the midpalatal suture, canine pillars, and pterygomaxillary junctions. By preserving mucosal integrity and vascular supply, this approach reduces postoperative morbidity and enhances recovery. A case involving a 35-year-old woman treated with this protocol using a bone-borne expander (HIMAME) demonstrated stable skeletal expansion and crossbite correction at a 3-year follow-up, with no complications or relapse. This method offers predictable skeletal outcomes with minimal dentoalveolar side effects, making it a viable outpatient alternative to conventional SARPE in adults. Further studies are warranted to validate long-term stability and to compare outcomes with other assisted expansion techniques.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102415"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}