Journal of Stomatology Oral and Maxillofacial Surgery最新文献

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Survival outcomes and prognostic factors in pediatric head and neck squamous cell carcinoma: A population-based study. 儿童头颈部鳞状细胞癌的生存结局和预后因素:一项基于人群的研究。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-17 DOI: 10.1016/j.jormas.2025.102501
Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao
{"title":"Survival outcomes and prognostic factors in pediatric head and neck squamous cell carcinoma: A population-based study.","authors":"Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao","doi":"10.1016/j.jormas.2025.102501","DOIUrl":"10.1016/j.jormas.2025.102501","url":null,"abstract":"<p><strong>Objective: </strong>This population-based cohort study aimed to offer a thorough analysis of head and neck squamous cell carcinoma (HNSCC) in pediatric and adolescent populations.</p><p><strong>Methods: </strong>We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) program, covering the period from 2000 to 2020. We included cases of primary HNSCC in patients aged 0-19 years with documented causes of death. Survival analysis was conducted using Kaplan-Meier methods, and differences in survival rates were assessed with the log-rank test. Cox proportional-hazards regression was applied to identify factors influencing overall survival (OS).</p><p><strong>Results: </strong>A total of 143 pediatric HNSCC cases were identified, with an average age of 15.4 years at diagnosis and a predominance of male patients (65 %). Tumor distribution was nearly equal between the oral cavity (46.8 %) and the nasopharynx (53.2 %). Nasopharyngeal HNSCC was associated with significantly better overall survival compared to oral cavity HNSCC (p = 0.017). Surgical treatment notably improved survival in oral cavity HNSCC cases (p = 0.022). Cox regression analysis revealed tumor site and chemotherapy as independent predictors of survival.</p><p><strong>Conclusions: </strong>Pediatric HNSCC is a rare condition with diverse survival outcomes based on tumor location. Our study highlights the effectiveness of surgical treatment for oral cavity HNSCC and underscores the importance of tumor site in prognostic assessments for overall survival.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102501"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When permanent lip makeup masks vascular occlusion, leading to intra-buccal and skin necrosis: Complications of full-face rejuvenation. 当永久性唇妆掩盖血管闭塞,导致颊内和皮肤坏死:全脸年轻化的并发症。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-17 DOI: 10.1016/j.jormas.2025.102503
M Majzoub, V Moris
{"title":"When permanent lip makeup masks vascular occlusion, leading to intra-buccal and skin necrosis: Complications of full-face rejuvenation.","authors":"M Majzoub, V Moris","doi":"10.1016/j.jormas.2025.102503","DOIUrl":"10.1016/j.jormas.2025.102503","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102503"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The zygomatic implant perforated flap in the reconstruction and early rehabilitation of low-level maxillectomies: A technical note. 颧骨植入穿孔皮瓣在下颌低位切除术重建和早期康复中的应用:技术要点。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-16 DOI: 10.1016/j.jormas.2025.102498
Maxime Lavigogne, Jordan Bouchet, Benjamin Pomes, Gaoussou Toure
{"title":"The zygomatic implant perforated flap in the reconstruction and early rehabilitation of low-level maxillectomies: A technical note.","authors":"Maxime Lavigogne, Jordan Bouchet, Benjamin Pomes, Gaoussou Toure","doi":"10.1016/j.jormas.2025.102498","DOIUrl":"10.1016/j.jormas.2025.102498","url":null,"abstract":"<p><p>The \"Zygomatic Implant Perforated Flap\" (ZIP flap) technique, first described by Butterworth in 2017, combines the closure of bucco-sinusal or bucco-nasal communications using a fasciocutaneous free flap with early implant-based prosthetic rehabilitation via zygomatic implants that perforate the flap. This approach enables rapid dental rehabilitation within weeks of tumor resection, promoting early recovery of oral function. We present the case of a 49-year-old male who underwent delayed ZIP flap reconstruction one year after maxillectomy and radiotherapy. Four zygomatic implants were placed using a surgical guide, followed by inset of a radial forearm free flap perforated over each implant emergence. A prefabricated transitional prosthesis was immediately screwed onto the implants. This technical note highlights the advantages of the ZIP flap in reconstructing Brown Class II maxillectomy defects, offering reduced rehabilitation time, improved prosthesis retention, and enhanced functional and psychological outcomes.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102498"},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of 3D impaction models and surgical plates in mesiodens. 三维嵌顿模型及手术钢板在中牙中的应用。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-16 DOI: 10.1016/j.jormas.2025.102499
Ryosuke Yoshizaki, Arihiro Nakamura, Hiroki Inoue, Atsushi Nakayama, Yuki Aoki, Eriko Nomura, Shunsuke Kako, Ken Miyazawa, Atsushi Abe, Tetsushi Oguma
{"title":"Application of 3D impaction models and surgical plates in mesiodens.","authors":"Ryosuke Yoshizaki, Arihiro Nakamura, Hiroki Inoue, Atsushi Nakayama, Yuki Aoki, Eriko Nomura, Shunsuke Kako, Ken Miyazawa, Atsushi Abe, Tetsushi Oguma","doi":"10.1016/j.jormas.2025.102499","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102499","url":null,"abstract":"<p><p>Supernumerary teeth are often extracted as they cause delayed eruption of permanent teeth, malocclusion, and infection. To avoid complications, such as damage to the permanent tooth embryo and adjacent tooth root, and errant extraction, we utilized digital technology to create a three-dimensional (3D) impaction model of the tooth and a surgical plate based on computed tomography (CT) data and intraoral scans. This study reports three cases of mesiodens extraction under general anesthesia, applying a 3D impaction model and a surgical plate. All patients were male and aged between 6 to 27 years. The extraction approach was palatal in two cases and labial in one; bone cutting was performed using ultrasonic cutting instruments. Mean operative time was 57 min, and bleeding was minimal with no intra- or post-operative complications. Development of 3D impaction models and surgical plates using digital technology and case reports are needed in future.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102499"},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maxillary Rehabilitation using subperiosteal implants associated with a Lefort 1 Osteotomy : a technical note. 采用骨膜下种植体联合Lefort 1截骨术进行上颌康复:技术说明。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-15 DOI: 10.1016/j.jormas.2025.102497
C Debortoli, O Rios, S Latreche, F Afota, R Castro, C Savoldelli
{"title":"Maxillary Rehabilitation using subperiosteal implants associated with a Lefort 1 Osteotomy : a technical note.","authors":"C Debortoli, O Rios, S Latreche, F Afota, R Castro, C Savoldelli","doi":"10.1016/j.jormas.2025.102497","DOIUrl":"10.1016/j.jormas.2025.102497","url":null,"abstract":"<p><strong>Introduction: </strong>With the advent of digital workflows, subperiosteal implants have experienced a resurgence. They offer a valuable solution for rehabilitating patients with severe maxillary atrophy. However, in cases involving an initial skeletal discrepancy, prosthetic compensation is often required. This report aims to minimize such compensation by combining subperiosteal implants with a Le Fort I osteotomy.</p><p><strong>Technical note: </strong>Le Fort I osteotomy and subperiosteal implant placement were performed under general anesthesia. The implants were osteosynthesized following the osteotomy, while maintaining proper occlusion through guided positioning.</p><p><strong>Conclusion: </strong>This technique requires significant surgical expertise. The addition of a Le Fort I osteotomy reduces prosthetic compensation and effectively addresses the sagittal skeletal discrepancy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102497"},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal evaluation of prognostic factors influencing the outcomes of functional appliance therapy in juvenile idiopathic arthritis patients with temporomandibular joint involvement. 影响颞下颌关节受损伤青少年特发性关节炎患者功能矫治器治疗预后因素的纵向评价。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-15 DOI: 10.1016/j.jormas.2025.102496
Dr A Selva Arockiam, Dr Jeroen van Dijk, Dr Sri Ram Venkatachalapathy, Dr Akash Ponnukumar, Dr Praveen Chandrashekaraiah, Dr Nithya Nandhini, Dr Anouk de Vries, Dr Luka Kovač
{"title":"Longitudinal evaluation of prognostic factors influencing the outcomes of functional appliance therapy in juvenile idiopathic arthritis patients with temporomandibular joint involvement.","authors":"Dr A Selva Arockiam, Dr Jeroen van Dijk, Dr Sri Ram Venkatachalapathy, Dr Akash Ponnukumar, Dr Praveen Chandrashekaraiah, Dr Nithya Nandhini, Dr Anouk de Vries, Dr Luka Kovač","doi":"10.1016/j.jormas.2025.102496","DOIUrl":"10.1016/j.jormas.2025.102496","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular joint (TMJ) involvement is a common yet under-recognized manifestation of Juvenile Idiopathic Arthritis (JIA) which can impair craniofacial growth and oral function. While early functional orthopaedic intervention holds promise, evidence from long-term studies evaluating outcomes and predictors of treatment response remains sparse.</p><p><strong>Materials and methods: </strong>This prospective longitudinal study included 84 children (mean age: 12.3 ± 2.1 years) diagnosed with JIA and clinical TMJ involvement. All participants were treated with a standardized modified twin-block appliance over a 2-year period. Clinical, skeletal, inflammatory and quality-of-life assessments were performed at six time points using Maximum Interincisal Opening (MIO), Visual Analog Scale (VAS) for pain, cephalometry (SNB angle), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), autoantibodies (RF, ANA, anti-CCP), cone-beam computed tomography (CBCT) and the OHIP-14 questionnaire. Prognostic factors and relapse were evaluated using multivariate regression and Kaplan-Meier survival analysis.</p><p><strong>Results: </strong>Over 24 months, patients demonstrated statistically significant improvement in MIO (+7.6 mm), VAS pain score (-3.9), SNB angle (+3.6°), ESR (-14.7 mm/hr) and CRP (-6.9 mg/L) (p < 0.001). Poorer outcomes were associated with RF/anti-CCP positivity, elevated baseline ESR/CRP, severe TMJ changes on CBCT and extra-articular involvement. In contrast, children aged ≤12 years with overjet ≤5 mm, SNB angle ≥76° and mild radiographic findings showed better therapeutic response. The 2-year relapse-free survival rate was 63.1 %.</p><p><strong>Conclusion: </strong>Modified twin-block therapy appears to be a promising adjunct for managing TMJ involvement in JIA. Early intervention, mild radiographic pathology and absence of seropositivity were strong predictors of sustained improvement highlighting the need for timely diagnosis and individualized orthopaedic planning.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102496"},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative complications in preseptal versus retroseptal transconjunctival approaches: A systematic review and meta-analysis. 间隔前与间隔后经结膜入路的术后并发症:一项系统回顾和荟萃分析。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-12 DOI: 10.1016/j.jormas.2025.102495
Amanjot Kaur, Karthik Sennimalai, Aparna Ganesan, Khalid Alotaibi, Essam Al-Moraissi
{"title":"Postoperative complications in preseptal versus retroseptal transconjunctival approaches: A systematic review and meta-analysis.","authors":"Amanjot Kaur, Karthik Sennimalai, Aparna Ganesan, Khalid Alotaibi, Essam Al-Moraissi","doi":"10.1016/j.jormas.2025.102495","DOIUrl":"10.1016/j.jormas.2025.102495","url":null,"abstract":"<p><p>Surgical correction of orbital fractures demands precise anatomical dissection with minimal complications. Transconjunctival incisions (TI) offer superior cosmetic outcomes, with two main techniques-preseptal (PS) and retroseptal (RS)-differing in anatomical pathways and associated risks. This systematic review and meta-analysis aimed to compare postoperative complications between PS and RS approaches. A comprehensive search of PubMed, Scopus, Ovid SP, Embase, Cochrane Library, and grey literature up to December 31, 2024, identified relevant studies. Inclusion criteria followed PICOT: adult patients with orbital fractures undergoing TI, comparing PS and RS techniques, with ≥1-month follow-up. Three studies (one RCT-split face design, two retrospective) involving 305 patients (PS: 245, RS: 253) were included. Data extraction and risk of bias assessment were independently performed by two reviewers using Cochrane RoB 2 and ROBINS-I. Meta-analysis with a random-effects model showed no significant differences between PS and RS in overall complications (OR = 0.93, 95 % CI: 0.51-1.71), ectropion (OR = 0.50, 95 % CI: 0.04-5.53), or entropion (OR = 3.02, 95 % CI: 0.12-74.49). Both techniques demonstrate comparable safety. Due to the limited number of studies and small sample size, findings should be considered preliminary. Surgical approach should be individualised, guided by anatomy, function, and the surgeon's expertise. Further high-quality RCTs are needed to strengthen surgical recommendations.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102495"},"PeriodicalIF":2.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic search and assessment of quality indicators in dental implantology. 种植牙学质量指标的系统检索与评价。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-09 DOI: 10.1016/j.jormas.2025.102494
L Verstraete, T-M Croonenborghs, P-J Verhelst, E Coeckelberghs, K Vanhaecht, C Politis, J Meeus
{"title":"Systematic search and assessment of quality indicators in dental implantology.","authors":"L Verstraete, T-M Croonenborghs, P-J Verhelst, E Coeckelberghs, K Vanhaecht, C Politis, J Meeus","doi":"10.1016/j.jormas.2025.102494","DOIUrl":"10.1016/j.jormas.2025.102494","url":null,"abstract":"<p><p>Measuring quality in healthcare is essential to improve the best practices and optimizing the use of resources. Despite some Quality of Care (QoC) initiatives in other medical specialties, little is known about this topic in Dental Implantology (DI). The aim of this study was to identify and evaluate quality indicators (QIs) by performing an importance-performance analysis (IPA) for DI. Identification of QIs was done based on a systematic search. Importance was assessed by experts through an online survey and performance was evaluated with a monocenter, retrospective study. Finally, importance-perfomance plots were constructed to identify quality improvement targets with cut-offs for level of importance (>75 %) and performance (>80 %). A total of 12 QIs were selected varying between structure, process and outcome variables. 5 indicators met the cut-off levels indicating high levels of importance as well as performance. However, there is still a need for further research to validate these possible indicators and to evaluate their final effect on the QoC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102494"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of absorbable internal fixation system in secondary rhinoplasty of patients with unilateral cleft lip. 可吸收内固定系统在单侧唇裂患者二次鼻整形中的应用。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-09 DOI: 10.1016/j.jormas.2025.102493
Wen Du, Changjiang Du, Lian Ma, Xia Zhou
{"title":"Application of absorbable internal fixation system in secondary rhinoplasty of patients with unilateral cleft lip.","authors":"Wen Du, Changjiang Du, Lian Ma, Xia Zhou","doi":"10.1016/j.jormas.2025.102493","DOIUrl":"10.1016/j.jormas.2025.102493","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nasal asymmetry is a common secondary deformity following correction of unilateral cleft lip, with insufficient structural reinforcement along the nasal midline representing a key etiological factor.</p><p><strong>Purpose: </strong>To address the clinical challenge of nasal asymmetry in unilateral cleft lip patients caused by insufficient midline nasal support, this study proposes the use of an absorbable internal fixation system for nasal scaffold reconstruction and evaluates its therapeutic efficacy.</p><p><strong>Methods: </strong>This retrospective study included patients with unilateral cleft lip nose. An absorbable internal fixation system was used in combination with the nasal septal cartilage to reconstruct the nasal cartilage framework. The participants were assessed preoperatively (T0), 1 week postoperatively (T1), and 6 months postoperatively (T2). The four measurements evaluated in this study were the nasal deviation angle (∠α), nasal height ratio (NH/NH'), nasal prominence angle (∠Al-Ns-Prn), and nasolabial angle (∠Cm-Sn-UL). One-way analysis of variance was used for the statistical analyses of the measurement results.</p><p><strong>Results: </strong>The sample was composed of 21 consecutive patients with a mean age of 19.04 ± 4.72, 11 (52.38 %) were male and 13 (61.9 %) had right cleft lip nose. No complications were observed during the follow-up period. The ∠α decreased significantly from T0 to T1 (P < 0.05), whereas the NH/NH' (P < 0.001), ∠Cm-Sn-UL (P < 0.001), and ∠Al-Ns-Prn (P < 0.01) increased significantly from T0 to T1. No statistical differences were observed between T2 and T1 in any measurements, except in the ∠Cm-Sn-UL (P < 0.001).</p><p><strong>Conclusion: </strong>The novel method proposed in this study effectively corrected the unilateral cleft lip nose and maintained stability during the follow-up period.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102493"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a prognostic tool using machine learning to identify high-risk mucoepidermoid carcinoma patients across diverse anatomical sites. 使用机器学习识别不同解剖部位的高危粘液表皮样癌患者的预后工具的开发。
IF 2.2 3区 医学
Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-09 DOI: 10.1016/j.jormas.2025.102490
Yun Lei, Wan-Shan Li
{"title":"Development of a prognostic tool using machine learning to identify high-risk mucoepidermoid carcinoma patients across diverse anatomical sites.","authors":"Yun Lei, Wan-Shan Li","doi":"10.1016/j.jormas.2025.102490","DOIUrl":"10.1016/j.jormas.2025.102490","url":null,"abstract":"<p><strong>Objective: </strong>Mucoepidermoid carcinoma (MEC), typically arising in the salivary glands, has been documented in various anatomical locations. This study aimed to develop machine learning models for efficient prognosis prediction in patients with MEC across different anatomical sites and to create a novel tool for identifying high-risk patients in clinical settings.</p><p><strong>Methods: </strong>A retrospective cohort study involving 6280 patients with MEC from diverse anatomical sites was conducted. COX regression analysis identified prognostic variables. Five machine learning models-Support Vector Machine (SVM), Random Forest (RF), Generalized Additive Model (GAM), Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM)-were constructed. Model performance was assessed using accuracy, recall, precision, and the area under the curve (AUC) of receiver operating characteristic (ROC) curves. However, the external validation was not performed. The best-performing model was developed into a prognostic tool.</p><p><strong>Results: </strong>The GAM outperformed the other models, and a web-based tool was developed for identifying patients with varying prognostic risks across MEC cases from different anatomical locations, supporting clinical decision-making, personalizing therapeutic strategies based on clinical characteristics, ensuring tailored treatment schedules and optimizing resource allocation. Extension, age, pathological grade, clinical stage, and N-stage were the most significant variables in the final model.</p><p><strong>Conclusion: </strong>This study established an online tool utilizing GAM to aid in identifying high-risk patients with MEC and enhancing prognostic accuracy in clinical practice. The anatomical site did not significantly influence survival outcomes, offering valuable insights into the shared pathogenesis of MEC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102490"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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