Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Artificial intelligent recognition for multiple supernumerary teeth in periapical radiographs based on faster R-CNN and YOLOv8.","authors":"Jiajia Zheng, Hong Li, Quan Wen, Yuan Fu, Jiaqi Wu, Hu Chen","doi":"10.1016/j.jormas.2025.102293","DOIUrl":"10.1016/j.jormas.2025.102293","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to compare the effectiveness of automated supernumerary tooth (ST) detection systems on periapical radiographs using Faster R-CNN and YOLOv8 with detection by 8 dental residents.</p><p><strong>Methods: </strong>This was a diagnostic accuracy study of 469 periapical radiographs (419 training vs. 50 test datasets). The primary predictor variables were detectors (dental residents/Faster R-CNN/YOLOv8). The main outcome variables included the diagnostic performance of the model's using precision, recall and intersection over union (IoU). Appropriate statistics were calculated.</p><p><strong>Results: </strong>In the test dataset, the precision of Faster R-CNN and YOLOv8 was 0.95 and 0.99, and their average precision was 0.90 and 0.97, respectively. A significant difference was observed between the two models in these metrics, with YOLOv8 outperforming Faster R-CNN in both precision and average precision (P<0.05). Both AI systems outperformed human subjects.</p><p><strong>Conclusions: </strong>Based on our findings, both YOLOv8 and Faster R-CNN are highly effective in the automated detection of ST in periapical radiographs and could, for example, assist humans in resource-limited situations.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102293"},"PeriodicalIF":2.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified workflow for dynamic navigation implant surgery in fully edentulous patients utilizing a customized patient tracking module.","authors":"Yufei Yao, Renli Yang, Waishan Lam, Xianglong Han, Xingmei Yang","doi":"10.1016/j.jormas.2025.102292","DOIUrl":"10.1016/j.jormas.2025.102292","url":null,"abstract":"<p><p>A refined navigated implant workflow for the edentulous patients is introduced utilizing a patient-customized tracking module. This technique initiates with the placement of an incisor implant to anchor the tracking module, enabling real-time tracing of the edentulous arch while eliminating the need for additional insertions. This approach optimizes surgical procedures, reduces trauma, and mitigates the risk of potential implant placement site occupation.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102292"},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary combination therapy of precision autotransplantation in complex impacted teeth based on CAD/CAM digital navigation.","authors":"Zun Yang, Ya Wang, Leilei Zheng, Jinlin Song","doi":"10.1016/j.jormas.2024.102144","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102144","url":null,"abstract":"<p><p>This study aimed to evaluate the efficiency and accuracy of autotransplantation of complex impacted teeth by CAD/CAM digital navigation technology. An 11-year-old girl with complex impacted second premolars bilaterally in the maxilla was selected. CAD/CAM digital dynamic navigation was utilized to ensure the precision and success of the procedure. A comprehensive accuracy analysis was conducted to compare the preoperative digital simulation design with the postoperative positions of the transplanted teeth. The transplanted teeth functioned well after 1 year of follow-up. Postoperative CBCT clinical data, combined with Mimics 21.0 and 3-Matic 13.0 software, revealed that the depth and buccolingual deviations of the bilateral autotransplantation were within 2.0 millimeters, with a mesiodistal deviation of approximately 1.0 millimeter. This case demonstrates the high efficiency, precision, and stabilization provided by digital navigation technology, highlighting its potential as a viable option for the treatment of complex impacted teeth.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102144"},"PeriodicalIF":2.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of ferroptosis-related genes in periodontitis through bioinformatics analysis and experimental validation.","authors":"Kecong Zhou, Huiwen Chen, Jiachen Dong, Zhongchen Song, Mengjun Sun","doi":"10.1016/j.jormas.2025.102291","DOIUrl":"10.1016/j.jormas.2025.102291","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a multifactorial chronic inflammatory disease of periodontal tissues. Ferroptosis is a form of regulated cell death, which is characterized by iron-dependent lipid peroxidation and involved in various inflammatory diseases. This study aims to identify ferroptosis-related genes associated with periodontitis and further validate their relevance through in vitro experiments.</p><p><strong>Methods: </strong>Iron accumulation and localization were detected using Prussian blue staining. Differentially expressed genes in periodontitis were identified from GSE16134 and GSE10334, and intersected with ferroptosis genes to obtain differentially expressed ferroptosis genes (FerDEGs). Functional enrichment analyses of FerDEGs were performed by GO and KEGG. Hub genes were screened through PPI network analysis. The expression of these hub genes in gingival tissues and in lipopolysaccharide (LPS)-stimulated human gingival fibroblasts (HGFs) with/without ferrostatin-1 (Fer-1) detected by qRT-PCR and Western Blot.</p><p><strong>Results: </strong>Ferroptosis was observed in gingival tissues affected by periodontitis. A total of 24 FerDEGs involved in periodontitis were identified. GO analysis and KEGG analysis highlighted the intrinsic apoptotic signaling pathway and ferroptosis as the top enriched pathways. PPI network analysis identified five hub genes. The mRNA expression levels of hub genes were significantly higher in inflammatory gingival tissues and HGFs stimulated with LPS (P < 0.05). The upregulated expression of PTGS2 and IL6 in HGFs were reversed by Fer-1 (P < 0.05).</p><p><strong>Conclusion: </strong>This study highlights five ferroptosis-related genes as potential targets for future research into the pathogenesis of periodontitis.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102291"},"PeriodicalIF":2.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of mixed lineage kinase domain-like pseudokinase (MLKL) in oral squamous cell carcinoma: A comparative evaluation between young and old patients.","authors":"Reshma Poothakulath Krishnan, Deepak Pandiar, Selvaraj Jayaraman, Pratibha Ramani","doi":"10.1016/j.jormas.2025.102279","DOIUrl":"10.1016/j.jormas.2025.102279","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is characterized by dysregulation of multiple cell signaling pathways, including the necroptotic pathway. Recently, the incidence of OSCC is increasing among the young population (below the age of 40 years). These patients exhibit differences in the pathobiological characteristics and treatment response compared to the older cohorts. There is a notable lack of research exploring the role of necroptotic proteins in younger OSCC patients.</p><p><strong>Aim: </strong>To investigate the expression of Mixed Lineage Kinase domain Like Pseudokinase (MLKL), a key necroptotic protein, in young and old patients with OSCC.</p><p><strong>Methodology: </strong>The study included sixty histopathologically confirmed cases of OSCC, categorized into two groups; Group I - 30 patients aged > 40 years and Group II - 30 patients aged ≤ 40 years. Each of these groups consisted of 10 cases each of well differentiated, moderately differentiated and poorly differentiated OSCC. The samples were evaluated for the MLKL gene expression using Real time PCR and the results were analyzed using the 2-ΔΔCT method.</p><p><strong>Results: </strong>The real-time PCR analysis showed a 31 % decrease in MLKL gene expression in the younger age group (Group II) compared to the older group. A decrease of 40 % in WDSCC, 67 % in MDSCC, and 38 % in PDSCC was observed in the younger group compared to the older age group.</p><p><strong>Conclusion: </strong>Our findings suggest age-related differences in necroptotic cell death regulation through MLKL, with decreased MLKL expression observed in younger patients compared to older patients. Modulating necroptotic cell death pathways in OSCC can promote switching between different cell death pathways and provide effective therapeutic strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102279"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental implants in solid organ transplant recipients: A systematic review and meta-analysis.","authors":"Yongying Chen, Liang Tang, Chufang Liao","doi":"10.1016/j.jormas.2025.102278","DOIUrl":"10.1016/j.jormas.2025.102278","url":null,"abstract":"<p><strong>Purpose: </strong>It remains to be determined whether dental implantation treatment in solid organ transplant (SOT) recipients and non-organ transplant patients yields similar clinical outcomes. This review summarizes related data for existing cases and presents a meta-analysis of the outcomes of dental implants in SOT recipients and non-organ transplant patients.</p><p><strong>Material and methods: </strong>An electronic literature search was conducted in the PubMed, Web of Sciences, Cochrane Library and China National Knowledge Infrastructure databases covering articles published from inception to December 2024. This study was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was designed based on the Population, Intervention, Comparison, Outcome and Study design (PICOS) framework. The risk of bias was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist or the Newcastle-Ottawa Scale (NOS). The certainty of findings was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Meta-analysis was performed using a fixed effects model to estimate the combined performance measures and 95 % confidence intervals for the implant survival rate, marginal bone loss (MBL), and probing depth (PD).</p><p><strong>Results: </strong>A total of 12 articles were included in the systematic review. The implant survival rate of 290 implants in 110 SOT recipients was 99.3 %. The meta-analysis of four case-control studies revealed no significant differences in the implant survival rate and PD between SOT recipients and non-organ transplant patients (P = 0.45 and P = 0.49, respectively), while there was slightly less MBL in SOT recipients (P = 0.02), possibly caused by confounding factors and bias.</p><p><strong>Conclusions: </strong>Organ transplantation does not impair implant survival in the short and mid-long term. Dental implantation can serve as a treatment option for tooth loss in SOT recipients.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102278"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National survey on implantation practices for free bone flaps: Key findings and insights.","authors":"Sophie Dugast, Leonor Guilmault, Isabelle Bouhier, Olivier Airaudo, Julie Longis, Helios Bertin","doi":"10.1016/j.jormas.2025.102271","DOIUrl":"10.1016/j.jormas.2025.102271","url":null,"abstract":"<p><strong>Background: </strong>In cervico-facial oncology, reconstructive procedures aim to ensure patient survival, restore orofacial functions, and maintain esthetic outcomes. The ultimate goal of these interventions is to provide functional rehabilitation. However, dental rehabilitation following bone-free flap reconstructions remains underutilized. This study evaluates current practices in France and identify the challenges reconstructive surgeons face in implementing dental implant rehabilitation after free bone flap reconstruction in an oncological setting.</p><p><strong>Methods: </strong>A nationwide survey was conducted across 52 French hospitals to assess practices related to free bone flap reconstructions and dental implant rehabilitation. An online questionnaire collected data on the epidemiology, rehabilitation practices, team organization, and willingness towards increasing the number of rehabilitated patients following oncological surgeries.</p><p><strong>Results: </strong>Nineteen centers responded, highlighting diverse practices. While most centers perform over 20 free bone flap reconstructions annually, the number of patients receiving implants post-reconstruction was relatively low, with most centers reporting between one and five implant procedures in the past year. Key obstacles to implant rehabilitation included patient irradiation (61 %), lack of financial support (61 %), absence of a practitioner network (50 %), insufficiently trained team members (33 %), risk of oncological recurrence (28 %), extended operating times for primary implantations (22 %), and difficulties with radiological follow-up due to artifacts (17 %) CONCLUSION: Despite its potential to enhance patient quality of life, dental implant rehabilitation in oncological patients remains marginal in France. This study highlights the need for standardized protocols and improved collaboration between reconstructive surgeons and dental specialists to increase the rate of rehabilitation following free bone flap reconstructions.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102271"},"PeriodicalIF":2.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of miR-141 overexpression on apoptosis and proliferation in Tscca and Tca8113 Cell Lines.","authors":"Tao Huang, Bo Shao, Zhong-Cheng Gong","doi":"10.1016/j.jormas.2025.102270","DOIUrl":"10.1016/j.jormas.2025.102270","url":null,"abstract":"<p><p>This study investigates the effect of miR-141 overexpression on the proliferation and apoptosis of tongue squamous cell carcinoma (TSCC) cell lines (Tscca and Tca8113). TSCC cells were stably transfected with a miR-141 lentivirus (Ubi-miR-141-SV40-EGFP-IRES-puromycin, miR-141 group) or an empty vector (Ubi-MCS-SV40-EGFP-IRES-puromycin, miR-NC group), with untreated cells serving as the Blank group. miR-141 expression was evaluated by rt-qPCR, transfection efficiency and apoptosis were assessed by flow cytometry, and cell proliferation was measured using the CCK-8 assay. Western blot and rt-qPCR were used to analyze the protein and mRNA expression of phosphatase and tensin homolog (PTEN) and B-cell lymphoma-2 (BCL2). Results: Flow cytometry confirmed successful establishment of stably transfected cell lines. The CCK-8 assay showed no significant difference in proliferation between the miR-NC and Blank groups (P > 0.05), while proliferation was significantly reduced in the miR-141 group. Apoptosis was significantly higher in the miR-141 group compared to both the miR-NC and Blank groups. Western blot and rt-qPCR analyses revealed upregulation of pten gene and PTEN protein expression, as well as downregulation of bcl2 gene and BCL2 protein expression in the miR-141 group relative to the miR-NC and Blank groups. Conclusion: In TSCC cells with high miR-141 expression, pten gene and PTEN protein levels were elevated, while bcl2 gene and BCL2 protein levels were reduced. These findings indicate that miR-141 may regulate the expression of PTEN and BCL2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. To our knowledge, this is the first study to explore the effects of miR-141 transfection in TSCC, providing valuable insights into its role in tumor progression and potential regulatory targets.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102270"},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital evaluation of the zygomatic buttress intra-oral donor site dimensions in different vertical facial growth types.","authors":"Ronald Younes, Bachar Husseini, Joseph Ryan Younes, Nabil Ghosn, Joe Najjar, Pia El Sayegh, Paul Fawaz, Joseph Bouserhal","doi":"10.1016/j.jormas.2025.102268","DOIUrl":"10.1016/j.jormas.2025.102268","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the influence of vertical facial growth patterns on the morphology of the zygomatic buttress (ZB) donor site and its implications for preoperative planning in bone grafting.</p><p><strong>Materials and methods: </strong>A total of 100 adult Cone beam computed tomography (CBCT) scans were analyzed and categorized into hypodivergent, normodivergent, and hyperdivergent groups based on SN-GoGn angles. Three-dimensional ZB models were created using semi-automatic segmentation, with key parameters-volume, surface area, thickness, and anteroposterior protrusion-measured using stable anatomical landmarks. Statistical analyses included descriptive statistics, one-way analysis of variance (ANOVA), Tukey's post-hoc tests, and Kruskal-Wallis H tests where necessary. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>ZB morphology varied significantly across facial growth types. Hypodivergent faces exhibited the highest bone volume (533.25 ± 129.58 mm³), surface area (560.70 ± 99.76 mm²), total thickness (4.68 ± 1.91 mm), and bulge thickness (9.75 ± 2.51 mm). Normodivergent faces showed intermediate values for bone volume (394.39 ± 141.62 mm³), surface area (504.27 ± 108.54 mm²), and thickness (2.79 ± 1.05 mm total, 5.42 ± 2.45 mm bulge). Hyperdivergent faces had the lowest bone volume (259.00 ± 86.28 mm³), surface area (422.64 ± 95.59 mm²), total thickness (1.70 ± 0.49 mm), and bulge thickness (3.57 ± 1.66 mm). Anteroposterior protrusion also differed significantly, with hypodivergent faces showing the largest protrusion (21.56 ± 3.24 mm).</p><p><strong>Conclusion: </strong>The ZB is a reliable donor site with morphology influenced by facial growth patterns. Preoperative radiographic assessment facilitates optimized surgical planning and tailored grafting strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102268"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgically assisted maxillary expansion: Influence of piezosurgery on the complications linked to the midline osteotomy.","authors":"Nuffer A, Veyssière A, Chatellier A, Preud'homme R, Bénateau H","doi":"10.1016/j.jormas.2025.102258","DOIUrl":"10.1016/j.jormas.2025.102258","url":null,"abstract":"<p><p>Transverse maxillary deficiency requires surgical maxillary expansion when the midpalatal suture is closed. The midline osteotomy of the maxilla can lead to significant dental, gingival and bone complications. Technically, this osteotomy is usually performed using osteotomes, a burr or an oscillating saw, but is increasingly being replaced by piezosurgery. There are no published studies on the impact of piezoelectric devices on complications. This study tries to evaluate complications after median inter-incisors osteotomy (gingival recession, tooth loss, bone loss) with piezosurgery, and then to compare them with complications associated with osteotomes. A single-center retrospective study of 57 patients who underwent surgical maxillary expansion was conducted. Dental complications (mobility, color and loss), gingival and papilla recession and bone defect were assessed before and at least 6 months after surgery. Two groups were compared: the piezosurgery P group (49 patients) and the osteotomes O group (8 patients). In piezosurgery group, 16.3 % of patients developed central papilla recession and 8 % bone defect, against 12.5 % and 0 % respectively in osteotomes group. No statistically significant difference was found between both groups in the incidence of gingival or bone complications.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102258"},"PeriodicalIF":2.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}