Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Multidisciplinary combination therapy of precision autotransplantation in complex impacted teeth based on CAD/CAM digital navigation.","authors":"Zun Yang, Ya Wang, Leilei Zheng, Jinlin Song","doi":"10.1016/j.jormas.2024.102144","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102144","url":null,"abstract":"<p><p>This study aimed to evaluate the efficiency and accuracy of autotransplantation of complex impacted teeth by CAD/CAM digital navigation technology. An 11-year-old girl with complex impacted second premolars bilaterally in the maxilla was selected. CAD/CAM digital dynamic navigation was utilized to ensure the precision and success of the procedure. A comprehensive accuracy analysis was conducted to compare the preoperative digital simulation design with the postoperative positions of the transplanted teeth. The transplanted teeth functioned well after 1 year of follow-up. Postoperative CBCT clinical data, combined with Mimics 21.0 and 3-Matic 13.0 software, revealed that the depth and buccolingual deviations of the bilateral autotransplantation were within 2.0 millimeters, with a mesiodistal deviation of approximately 1.0 millimeter. This case demonstrates the high efficiency, precision, and stabilization provided by digital navigation technology, highlighting its potential as a viable option for the treatment of complex impacted teeth.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102144"},"PeriodicalIF":2.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of ferroptosis-related genes in periodontitis through bioinformatics analysis and experimental validation.","authors":"Kecong Zhou, Huiwen Chen, Jiachen Dong, Zhongchen Song, Mengjun Sun","doi":"10.1016/j.jormas.2025.102291","DOIUrl":"10.1016/j.jormas.2025.102291","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a multifactorial chronic inflammatory disease of periodontal tissues. Ferroptosis is a form of regulated cell death, which is characterized by iron-dependent lipid peroxidation and involved in various inflammatory diseases. This study aims to identify ferroptosis-related genes associated with periodontitis and further validate their relevance through in vitro experiments.</p><p><strong>Methods: </strong>Iron accumulation and localization were detected using Prussian blue staining. Differentially expressed genes in periodontitis were identified from GSE16134 and GSE10334, and intersected with ferroptosis genes to obtain differentially expressed ferroptosis genes (FerDEGs). Functional enrichment analyses of FerDEGs were performed by GO and KEGG. Hub genes were screened through PPI network analysis. The expression of these hub genes in gingival tissues and in lipopolysaccharide (LPS)-stimulated human gingival fibroblasts (HGFs) with/without ferrostatin-1 (Fer-1) detected by qRT-PCR and Western Blot.</p><p><strong>Results: </strong>Ferroptosis was observed in gingival tissues affected by periodontitis. A total of 24 FerDEGs involved in periodontitis were identified. GO analysis and KEGG analysis highlighted the intrinsic apoptotic signaling pathway and ferroptosis as the top enriched pathways. PPI network analysis identified five hub genes. The mRNA expression levels of hub genes were significantly higher in inflammatory gingival tissues and HGFs stimulated with LPS (P < 0.05). The upregulated expression of PTGS2 and IL6 in HGFs were reversed by Fer-1 (P < 0.05).</p><p><strong>Conclusion: </strong>This study highlights five ferroptosis-related genes as potential targets for future research into the pathogenesis of periodontitis.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102291"},"PeriodicalIF":2.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of mixed lineage kinase domain-like pseudokinase (MLKL) in oral squamous cell carcinoma: A comparative evaluation between young and old patients.","authors":"Reshma Poothakulath Krishnan, Deepak Pandiar, Selvaraj Jayaraman, Pratibha Ramani","doi":"10.1016/j.jormas.2025.102279","DOIUrl":"10.1016/j.jormas.2025.102279","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is characterized by dysregulation of multiple cell signaling pathways, including the necroptotic pathway. Recently, the incidence of OSCC is increasing among the young population (below the age of 40 years). These patients exhibit differences in the pathobiological characteristics and treatment response compared to the older cohorts. There is a notable lack of research exploring the role of necroptotic proteins in younger OSCC patients.</p><p><strong>Aim: </strong>To investigate the expression of Mixed Lineage Kinase domain Like Pseudokinase (MLKL), a key necroptotic protein, in young and old patients with OSCC.</p><p><strong>Methodology: </strong>The study included sixty histopathologically confirmed cases of OSCC, categorized into two groups; Group I - 30 patients aged > 40 years and Group II - 30 patients aged ≤ 40 years. Each of these groups consisted of 10 cases each of well differentiated, moderately differentiated and poorly differentiated OSCC. The samples were evaluated for the MLKL gene expression using Real time PCR and the results were analyzed using the 2-ΔΔCT method.</p><p><strong>Results: </strong>The real-time PCR analysis showed a 31 % decrease in MLKL gene expression in the younger age group (Group II) compared to the older group. A decrease of 40 % in WDSCC, 67 % in MDSCC, and 38 % in PDSCC was observed in the younger group compared to the older age group.</p><p><strong>Conclusion: </strong>Our findings suggest age-related differences in necroptotic cell death regulation through MLKL, with decreased MLKL expression observed in younger patients compared to older patients. Modulating necroptotic cell death pathways in OSCC can promote switching between different cell death pathways and provide effective therapeutic strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102279"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental implants in solid organ transplant recipients: A systematic review and meta-analysis.","authors":"Yongying Chen, Liang Tang, Chufang Liao","doi":"10.1016/j.jormas.2025.102278","DOIUrl":"10.1016/j.jormas.2025.102278","url":null,"abstract":"<p><strong>Purpose: </strong>It remains to be determined whether dental implantation treatment in solid organ transplant (SOT) recipients and non-organ transplant patients yields similar clinical outcomes. This review summarizes related data for existing cases and presents a meta-analysis of the outcomes of dental implants in SOT recipients and non-organ transplant patients.</p><p><strong>Material and methods: </strong>An electronic literature search was conducted in the PubMed, Web of Sciences, Cochrane Library and China National Knowledge Infrastructure databases covering articles published from inception to December 2024. This study was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was designed based on the Population, Intervention, Comparison, Outcome and Study design (PICOS) framework. The risk of bias was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist or the Newcastle-Ottawa Scale (NOS). The certainty of findings was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Meta-analysis was performed using a fixed effects model to estimate the combined performance measures and 95 % confidence intervals for the implant survival rate, marginal bone loss (MBL), and probing depth (PD).</p><p><strong>Results: </strong>A total of 12 articles were included in the systematic review. The implant survival rate of 290 implants in 110 SOT recipients was 99.3 %. The meta-analysis of four case-control studies revealed no significant differences in the implant survival rate and PD between SOT recipients and non-organ transplant patients (P = 0.45 and P = 0.49, respectively), while there was slightly less MBL in SOT recipients (P = 0.02), possibly caused by confounding factors and bias.</p><p><strong>Conclusions: </strong>Organ transplantation does not impair implant survival in the short and mid-long term. Dental implantation can serve as a treatment option for tooth loss in SOT recipients.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102278"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of miR-141 overexpression on apoptosis and proliferation in Tscca and Tca8113 Cell Lines.","authors":"Tao Huang, Bo Shao, Zhong-Cheng Gong","doi":"10.1016/j.jormas.2025.102270","DOIUrl":"10.1016/j.jormas.2025.102270","url":null,"abstract":"<p><p>This study investigates the effect of miR-141 overexpression on the proliferation and apoptosis of tongue squamous cell carcinoma (TSCC) cell lines (Tscca and Tca8113). TSCC cells were stably transfected with a miR-141 lentivirus (Ubi-miR-141-SV40-EGFP-IRES-puromycin, miR-141 group) or an empty vector (Ubi-MCS-SV40-EGFP-IRES-puromycin, miR-NC group), with untreated cells serving as the Blank group. miR-141 expression was evaluated by rt-qPCR, transfection efficiency and apoptosis were assessed by flow cytometry, and cell proliferation was measured using the CCK-8 assay. Western blot and rt-qPCR were used to analyze the protein and mRNA expression of phosphatase and tensin homolog (PTEN) and B-cell lymphoma-2 (BCL2). Results: Flow cytometry confirmed successful establishment of stably transfected cell lines. The CCK-8 assay showed no significant difference in proliferation between the miR-NC and Blank groups (P > 0.05), while proliferation was significantly reduced in the miR-141 group. Apoptosis was significantly higher in the miR-141 group compared to both the miR-NC and Blank groups. Western blot and rt-qPCR analyses revealed upregulation of pten gene and PTEN protein expression, as well as downregulation of bcl2 gene and BCL2 protein expression in the miR-141 group relative to the miR-NC and Blank groups. Conclusion: In TSCC cells with high miR-141 expression, pten gene and PTEN protein levels were elevated, while bcl2 gene and BCL2 protein levels were reduced. These findings indicate that miR-141 may regulate the expression of PTEN and BCL2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. To our knowledge, this is the first study to explore the effects of miR-141 transfection in TSCC, providing valuable insights into its role in tumor progression and potential regulatory targets.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102270"},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital evaluation of the zygomatic buttress intra-oral donor site dimensions in different vertical facial growth types.","authors":"Ronald Younes, Bachar Husseini, Joseph Ryan Younes, Nabil Ghosn, Joe Najjar, Pia El Sayegh, Paul Fawaz, Joseph Bouserhal","doi":"10.1016/j.jormas.2025.102268","DOIUrl":"10.1016/j.jormas.2025.102268","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the influence of vertical facial growth patterns on the morphology of the zygomatic buttress (ZB) donor site and its implications for preoperative planning in bone grafting.</p><p><strong>Materials and methods: </strong>A total of 100 adult Cone beam computed tomography (CBCT) scans were analyzed and categorized into hypodivergent, normodivergent, and hyperdivergent groups based on SN-GoGn angles. Three-dimensional ZB models were created using semi-automatic segmentation, with key parameters-volume, surface area, thickness, and anteroposterior protrusion-measured using stable anatomical landmarks. Statistical analyses included descriptive statistics, one-way analysis of variance (ANOVA), Tukey's post-hoc tests, and Kruskal-Wallis H tests where necessary. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>ZB morphology varied significantly across facial growth types. Hypodivergent faces exhibited the highest bone volume (533.25 ± 129.58 mm³), surface area (560.70 ± 99.76 mm²), total thickness (4.68 ± 1.91 mm), and bulge thickness (9.75 ± 2.51 mm). Normodivergent faces showed intermediate values for bone volume (394.39 ± 141.62 mm³), surface area (504.27 ± 108.54 mm²), and thickness (2.79 ± 1.05 mm total, 5.42 ± 2.45 mm bulge). Hyperdivergent faces had the lowest bone volume (259.00 ± 86.28 mm³), surface area (422.64 ± 95.59 mm²), total thickness (1.70 ± 0.49 mm), and bulge thickness (3.57 ± 1.66 mm). Anteroposterior protrusion also differed significantly, with hypodivergent faces showing the largest protrusion (21.56 ± 3.24 mm).</p><p><strong>Conclusion: </strong>The ZB is a reliable donor site with morphology influenced by facial growth patterns. Preoperative radiographic assessment facilitates optimized surgical planning and tailored grafting strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102268"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of professional oral hygiene in enhancing outcomes of maxillofacial trauma surgery.","authors":"Giuseppe Consorti, Giulio Cirignaco, Gabriele Monarchi, Lisa Catarzi, Mariagrazia Paglianiti, Enrico Betti, Umberto Committeri, Lucrezia Togni, Marco Mascitti, Paolo Balercia, Andrea Santarelli","doi":"10.1016/j.jormas.2025.102269","DOIUrl":"10.1016/j.jormas.2025.102269","url":null,"abstract":"<p><strong>Background: </strong>The oral cavity poses challenges in surgical interventions due to its microbial flora. Maxillofacial trauma surgeries are vulnerable to infections, complicating recovery. Traditional methods, including antibiotic prophylaxis, have limitations, highlighting the need for complementary strategies.</p><p><strong>Objective: </strong>This study evaluated the impact of professional oral hygiene protocol on infection rates, mucosal health, and pain levels in maxillofacial trauma patients.</p><p><strong>Material and methods: </strong>A retrospective study analyzed 529 patients treated for maxillofacial trauma at the Maxillo-Facial Surgery Unit of \"Azienda Ospedaliera Ospedali Riuniti\" in Ancona, Italy, from 2018 to 2023. Patients were divided into two groups: Period 1 (2018-2020, no protocol) and Period 2 (2021-2023, protocol implemented). All patients were in good general health, with no systemic diseases compromising immunity or influencing surgical outcomes. The protocol included supragingival scaling 48 h preoperatively, chlorhexidine 0.20 % three times daily postoperatively, and standardized antibiotic and analgesic regimens. Data included infection rates, modified Beck Oral Assessment Scores and Numerical Rating Scale pain scores. Statistical analyses included independent t-tests and Chi-square tests, with significance set at p < 0.05.</p><p><strong>Results: </strong>Period 2 showed significantly lower infection rates (13.44 % vs. 19.48 %, p = 0.023), reduced pain scores (mean NRS: 4.6 vs. 5.4, p < 0.01) and improved mucosal health (mean BOAS: 2.91 vs. 3.75, p < 0.001).</p><p><strong>Discussion: </strong>The professional oral hygiene protocol reduced postoperative complications, improved oral health, and enhanced patient comfort. These findings support the integration of structured oral hygiene measures into standard maxillofacial surgical care to optimize outcomes and quality of life.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102269"},"PeriodicalIF":2.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of staging system and treatment guideline for diagnostically challenging primary intra-osseous carcinoma: A retrospective single-center case series and literature review.","authors":"Dong-Ho Cho, Hoon Myoung, Mi Hyun Seo","doi":"10.1016/j.jormas.2025.102259","DOIUrl":"10.1016/j.jormas.2025.102259","url":null,"abstract":"<p><p>The objective of this retrospective study is to examine the clinical, imaging and pathologic features of 10 patients diagnosed with 'primary intraosseous carcinoma (PIOC)' at a single institution and to identify factors affecting the prognosis of PIOC patients. By proposing a new staging system based on tumor size, cortical bone deformation, neck metastasis and histologic grade, the study aims to address the lack of a distinct staging system, which has led to the mixed use of the classification for oral squamous cell carcinoma (OSCC). Furthermore, the study intends to suggest a treatment guideline based on the newly proposed staging system. By sharing the accumulated experience of treating PIOC patients at a single institution, the study seeks to contribute to more accurate diagnosis and appropriate treatment.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102259"},"PeriodicalIF":2.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NKAP: A new m6A RNA binding protein predicts prognosis and immunotherapy response in head and neck squamous cell carcinoma.","authors":"Paramasivam Arumugam, Jeevitha Manicka Vasagam, Vijayashree Priyadharsini Jayaseelan","doi":"10.1016/j.jormas.2025.102265","DOIUrl":"10.1016/j.jormas.2025.102265","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether NKAP (nuclear factor κB activating protein) serves as a prognostic marker and predictive biomarker for immunotherapy response in head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>A retrospective cohort study combined with in vitro analyses was conducted. NKAP mRNA expression levels were assessed in 520 HNSCC tumor tissues and 44 normal tissues from the TCGA dataset and validated in a clinical cohort (n = 32). Clinical correlations with overall survival and immunotherapy outcomes were analyzed. The key pathological variables included tumor stage, grade, HPV status, and TP53 mutation. Appropriate statistics were calculated at a significant level (P<0.05).</p><p><strong>Results: </strong>In this study, we have collected tissue samples from HNSCC patients (mean age: 52.65 ± 7.76; males 66%, females 34%). NKAP was upregulated in HNSCC tissues compared to adjacent normal tissues (P < 0.001). The high expression of NKAP correlated with advanced tumor stage, grade, and reduced survival (P < 0.05). High expression levels of NKAP were also associated with anti-PD-L1 therapy response (P < 0.05). Functional enrichment analysis revealed NKAP involvement in cell cycle regulation, mRNA processing, and chromatin remodeling pathways critical for cancer progression.</p><p><strong>Conclusion: </strong>NKAP represents a promising prognostic marker and therapeutic target for immunotherapy in HNSCC. Prospective studies are warranted to confirm these findings.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102265"},"PeriodicalIF":2.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additively manufactured subperiosteal implants for the rehabilitations of Lateral Incisors Agenesis - A case series.","authors":"Marco Roy, Mauro Cerea, Wieslaw Hedzelek, Luigi Angelo Vaira, Barbara Dorocka-Bobkowska","doi":"10.1016/j.jormas.2025.102263","DOIUrl":"10.1016/j.jormas.2025.102263","url":null,"abstract":"<p><strong>Background: </strong>Tooth agenesis, particularly the absence of upper lateral incisors, presents substantial challenges for clinicians due to the associated bone atrophy, which limits the use of traditional implant solutions. Current options, such as endosseous implants combined with guided bone regeneration (GBR), often fail due to insufficient osseointegration in atrophic bone. This study aims to evaluate the effectiveness of custom-made, additively manufactured subperiosteal implants in addressing these challenges METHODS: This retrospective study assessed 16 custom-made subperiosteal implants used in 12 patients (10 females, 2 males; mean age 25 ± 2.3 years) with lateral incisor agenesis who had previously experienced early implant failure with conventional endosseous implants. The protocol included subperiosteal implants combined with bovine bone grafts and PRF membranes, allowing for immediate loading and correct prosthetic alignment. Clinical evaluations focused on implant stability, peri-implant tissue health and esthetic (including probing depths and bleeding on probing), and prosthetic success over time.</p><p><strong>Results: </strong>During a follow-up period of 18 to 64 months (mean 48 ± 6.7 months), all patients maintained stable implants, with no implant failures reported. Biological outcomes demonstrated stable peri-implant health, with probing depths averaging 3 mm and minimal signs of inflammation. The mean pink esthetic score was 12.3 ± 1.1 (range: 10 to 14). Prosthetic complications were limited to minor adjustments, with two cases requiring recementing of crowns after three years.</p><p><strong>Conclusions: </strong>The results indicate that this new protocol provides a reliable, single-procedure solution for the rehabilitation of lateral incisor agenesis in patients with significant bone atrophy, achieving a 100 % success rate in this study. Despite promising outcomes, the study is limited by a small sample size and the need for longer follow-up to assess durability. This approach offers a viable alternative for patients where traditional implants are not feasible due to bone deficiencies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102263"},"PeriodicalIF":2.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}