Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Survival study of cervico-facial melanomas at 3 years without recurrence: impact of non-analysis of the sentinel lymph node.","authors":"Pauline Tschamber, Elise Boudousq, Leila Essid, Bertille Bonniaud, Géraldine Jeudy, Anne Fevre, Karine Goueslard, David Guillier","doi":"10.1016/j.jormas.2025.102536","DOIUrl":"10.1016/j.jormas.2025.102536","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of melanoma of the head and neck has been steadily increasing over the last decades. Until now, sentinel lymph node analysis has been the most important prognostic factor for survival in the management of melanoma. The cervicofacial region has a complex lymphatic drainage system and sentinel node biopsy in this region is still the subject of debate. The main objective of this study was to compare the 3-year recurrence-free survival of patients who had undergone a successful sentinel node procedure with that of patients who had not undergone sentinel node analysis.</p><p><strong>Method: </strong>The observational and retrospective study focused on patients with cervicofacial melanoma who were treated at the Dijon University Hospital for a surgical and technical revision of the sentinel lymph node between January 2005 and December 2021.</p><p><strong>Results: </strong>Sixty-eight patients were included, 47 of whom were able to undergo surgery and benefit from the sentinel node technique. The main reason for the failure of this technique was the impossibility of locating the sentinel node during preoperative lymphoscintigraphy (52.4 %). No statistically significant difference (p = 0.87) in 3-year recurrence-free survival was observed between the group of patients who did not undergo a successful sentinel node procedure and the group of patients who were able to fully benefit from it.</p><p><strong>Conclusion: </strong>Three-year recurrence-free survival was not affected by the absence of sentinel node analysis in cases of melanoma of the head and neck when indicated, compared to sentinel node removal and analysis.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102536"},"PeriodicalIF":2.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric analysis of maxillary sinus, sphenod sinus and pterygopalatin fossa in different skeletal malocclusions.","authors":"Merve Kucuk Kurtgoz, Zarif Ece Hammudioglu, Ceren Aktuna Belgin","doi":"10.1016/j.jormas.2025.102535","DOIUrl":"10.1016/j.jormas.2025.102535","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the changes in maxillary sinus volume (MSV), sphenoid sinus volume (SSV), and pterygopalatine fossa volume (PPFV) in different skeletal malocclusions using cone beam computed tomography (CBCT) images.</p><p><strong>Methods: </strong>CBCT images of 600 patients (318 females and 282 males) aged between 18 and 73 years (mean: 31.3 ± 12.9 years) were evaluated. Firstly, all patients were divided into classes according to their skeletal malocclusion. A threshold range between -1024 HU and -526 HU was applied for making paranasal sinuses. In all sections in all three planes, it was checked that MS, SS, and PPF were separated from other anatomical landmarks and the airway.</p><p><strong>Results: </strong>All MSV, SSV, and PPFV values ​​were found to be significantly higher in males than in females (p > 0.05). MSV was statistically significantly higher in Class III malocclusion than in Class I and II malocclusion (p < 0.05), whereas there was no significant difference between Class I and II malocclusion (p > 0.05). No statistically significant correlation was found between SSV and skeletal malocclusion classes (p > 0.05). PPFV had the highest value in Class I malocclusion, followed by Class III and Class II, and there was a statistically significant difference between them (p < 0.05).</p><p><strong>Conclusion: </strong>MSV, SSV, and PPFV have been observed to show significant changes depending on sexual dimorphism; MSV in Class III skeletal malocclusion, and PPFV in Class I skeletal malocclusion. Knowing the dimensions of the anatomy and anatomical structures specific to the individual before surgical interventions in these regions will also reduce the risk of complications.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102535"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual effects of bisphosphonates on bone metabolism and implant osseointegration: mechanisms, risks and clinical strategies.","authors":"Hongqi Liu, Xinjing Wang, Yueyi Shi, Yanmei Yang, Pengli Li, Qi Chen, Yawen Hu, Jian Wang, Bin Gu","doi":"10.1016/j.jormas.2025.102534","DOIUrl":"10.1016/j.jormas.2025.102534","url":null,"abstract":"<p><p>Osseointegration is the fundamental mechanism facilitating the direct bonding between implants and bone tissue, which significantly influences the success and long-term stability of the implant. Bisphosphonates, potent antiresorptive agents, are widely utilized in the treatment of osteoporosis and other bone metabolic disorders due to their capacity to inhibit osteoclast activity. However, their effects on implant osseointegration present a 'double-edged sword.' Bisphosphonates inhibit mitochondrial ADP/ATP translocase through an interaction with class II aminoacyl-tRNA synthetase, leading to osteoclast apoptosis. Conversely, they also inhibit the prenylation of small GTPases, disrupting cytoskeletal integrity and vesicular transport, ultimately resulting in osteoclast apoptosis. In osteoblasts, low concentrations of bisphosphonates promote differentiation and bone formation, while high concentrations hinder bone metabolism. Animal experiments and clinical studies have demonstrated that the local application of bisphosphonates, such as through implant coatings, significantly enhances the strength of osseointegration and reduces marginal bone resorption. Furthermore, synergistic effects can be achieved when bisphosphonates are combined with parathyroid hormone or basic fibroblast growth factor (bFGF). However, systemic prolonged use of bisphosphonates, particularly through intravenous administration, may excessively inhibit bone remodeling. This can lead to increased rates of osseointegration failure, a heightened risk of jaw necrosis, and impaired soft-tissue healing. Current challenges focus on regulating the drug concentration window, resolving jawbone-specific sensitization mechanisms, and optimizing both systemic and local drug delivery strategies. In the future, it will be essential to integrate the regulation of the bone immune microenvironment, the development of novel coating materials, and multicenter clinical studies to balance efficacy and risk, thereby promoting the establishment of individualized implant treatment strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102534"},"PeriodicalIF":2.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of the m6A modulator ELF3 and its impact on carcinogenesis and prognosis in oral squamous cell carcinoma.","authors":"Karpakavinayakam Gopalakrishnan, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam","doi":"10.1016/j.jormas.2025.102532","DOIUrl":"10.1016/j.jormas.2025.102532","url":null,"abstract":"<p><strong>Objective: </strong>Oral squamous cell carcinoma (OSCC) is a prevalent and invasive cancer with poor prognosis, demanding the identification of innovative biomarkers and therapeutic targets. Currently, there is a growing concern on the role of novel m6A reader E74-like factor 3 (ELF3) in tumorigenesis. This study investigated the oncogenic role of ELF3 in OSCC.</p><p><strong>Methods: </strong>Expression of ELF3 in OSCC tissues was analyzed using a comprehensive approach, including RT-qPCR, western blotting, and IHC. The Cancer Genome Atlas (TCGA-HNSCC) dataset and clinicopathological features along with immune signatures in patients with HNSCC were analyzed. The survival rate of patients with HNSCC was studied with Kaplan-Meier analysis. Moreover, bioinformatic strategies were used to analyze ELF3 protein networks and functional pathways involved in oral carcinogenesis.</p><p><strong>Results: </strong>ELF3 is downregulated in OSCC tumor tissues and is associated with advanced clinicopathologic features, nodal metastasis and poorer survival outcome. From the functional enrichment analysis, ELF3 participates in core pathways such as DNA transcription, transcriptional dysregulation in cancer, NOTCH translation and oral carcinoma pathways. Additionally, a negative correlation exists between ELF3 expression levels and immune cell infiltration, as well as immune gene modulation in the tumor microenvironment.</p><p><strong>Conclusion: </strong>Our findings imply that ELF3 can be used as a promising biomarker for OSCC prognosis along with a therapeutic target to reduce cancer metastasis and enhance patient outcomes. Additional research is required to corroborate these findings and investigate the molecular pathways associated with ELF3 function in OSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102532"},"PeriodicalIF":2.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of manipulation and therapeutic exercise applied to the neck region of patients with temporomandibular disorders: A systematic review and meta-analysis.","authors":"Jianing Qu, Yingqiu Qian, Yi Zhang, Bocheng Chen, Ruohan Wang, Jie Bao, Xi Huang, Yunhang Lu","doi":"10.1016/j.jormas.2025.102530","DOIUrl":"10.1016/j.jormas.2025.102530","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate comprehensively and quantitatively the efficacy of manipulation and therapeutic exercise acting on the neck region of patients with myogenous temporomandibular joint disorders (TMD) using meta-analysis.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) in regard to this issue were searched in electronic databases. The timeframe was from the starting year of inclusion in each database to 25 December 2024 for all searches. The eligible literature was screened according to the inclusion criteria, and meta-analysis of the eligible studies was performed using Review Manager 5.4. The primary outcome measure was the degree of pain, reported on a visual analog scale (VAS), the numerical pain rating scale (NPRS), biting muscle pressure pain thresholds (PPT) and the maximum mouth opening (MMO). Pooled effect sizes were calculated using random effects models and 95 % confidence interval (95 % CI).</p><p><strong>Results: </strong>Fourteen RCTs comprising 825 patients were included. Meta-analysis showed that manipulative therapy and therapeutic exercise acting on the neck region had a significant effect in NPRS (SMD = -0.49; 95 % CI = [-0.93, -0.04]; p = 0.03), VAS (SMD = -0.64; 95 % CI = [-1.20, -0.08]; p = 0.002), and PPT (SMD = 0.40; 95 % CI = [0.21, 0.58]; p < 0.0001). No significant effect was observed in improving MMO in patients with TMD (SMD = 0.41; 95 % CI = [-0.45, 1.28]; p = 0.32), but in subgroup analyses based on the type of intervention, manipulative therapy combined with therapeutic neck exercises was effective in improving the MMO in patients with TMD (SMD = 0.45; 95 % CI = [0.12, 0.78]; p < 0.008).</p><p><strong>Conclusion: </strong>Manipulation and therapeutic exercise in the neck region can effectively improve the maxillofacial pain intensity and muscle-related PPT in patients with TMD. Manipulation alone has a negligible effect on improving MMO, but the combination of manipulation and therapeutic exercise in the neck can effectively improve MMO in patients with myogenous TMD. However, many manipulative treatments and therapeutic exercises can be used for the treatment of TMD with varying effects, and more well-designed large-sample RCTs are needed for further validation.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102530"},"PeriodicalIF":2.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of disc-condyle movement following disc repositioning operation by arthroscopic for Bi-ADD patients.","authors":"Chenxi Jin, Wei Shen, Na Li, Jianfeng Sun, Dongyu Hou, Chi Yang, Jing Guo","doi":"10.1016/j.jormas.2025.102533","DOIUrl":"10.1016/j.jormas.2025.102533","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the location of disc and the movement characteristic of disc-condyle following disc repositioning operation by bilateral arthroscopic (Bi-ADRO).</p><p><strong>Methods: </strong>The consecutive patients enrolled, who received magnetic resonance imaging (MRI), 84 patients were included. 31 patients distributing in group N diagnosed as non-ADD. 53 patients, with 87 joints diagnosed with anterior disc displacement without reduction (ADDWoR) assigned to the surgical group (group A), who underwent the Bi-ADRO, with postoperative follow-ups at 1 (A_1M), 3 (A_3M), and 6 (A_6M) months. The statistical analysis was IBM SPSS Statistics v.27.0, p<0.05 was considered significant.</p><p><strong>Results: </strong>1. The group N showed a significant increase in painless maximum vertical opening (MVO) compared to baseline measurements (p < 0.05). The group A₀ demonstrated significantly lower MVO than the group N (p < 0.001). Statistically significant differences in MVO were observed across all A_0-6M follow-up intervals compared to baseline (p < 0.05). 2. 1) In the coronal view, rare disc displacement was showed in group N, whereas discs were invisible in A₀; partially visible in A_6M, with lateral displacement 11/42, which can be seen at the disc-condyle angle of -29.14°±32.49°. 2) In the sagittal view, disc-condyle angles between group N and A₀, A_6M in both closed and opening were significantly different (p < 0.001). 3) Significant differences were observed in mobility between group N and A₀, A_6M (p < 0.001). 3. Postoperative changes in disc-condyle angles and mobility over time: 1) In the coronal view, disc visibility improved, with persistent lateral displacement. 2) In the sagittal view, disc-condyle angles increased over time, while the rate of increase diminished. 3) Mobility progressively increased in the groups A_1M∼6M, with significant intergroup differences (p < 0.05). 4. The changes of disc-condyle angle over time were negatively correlated with the surgical disc position: closed: p < 0.001, r=-0.508; p < 0.001, r=-0.522; opening: p < 0.05, r=-0.212; p < 0.05, r=-0.232.</p><p><strong>Conclusions: </strong>Following ADRO, progressive restoration of MVO was observed. Bi-ADRO improved disc position, with sagittal repositioning being more pronounced than coronal. Sagittal disc position exhibited anterior displacement over time; disc movement was predominantly vertical, while condylar primarily sagittal. The most pronounced changes in disc-condyle mobility occurred at 3 months. The 0°∼-60° are favorable disc-repositioned because of optimal mobility and have the potential to be recommended.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102533"},"PeriodicalIF":2.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of invisible mandibular advancement appliances in treating adolescent skeletal class II malocclusion and their impact on temporomandibular joint morphology.","authors":"Yi Sun, Xiaoan Luo, Liping Huang, Jing Zhou, Jianlu Shi, Zhisheng Zhang","doi":"10.1016/j.jormas.2025.102529","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102529","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze the clinical efficacy of invisible mandibular advancement appliances in treating adolescent skeletal Class II malocclusion and their impact on temporomandibular joint (TMJ) morphology.</p><p><strong>Methods: </strong>Seventy-two adolescent patients with skeletal Class II malocclusion were divided into a control group treated with straight wire appliances and a study group treated with invisible mandibular advancement appliances. Changes in TMJ-related angles, facial height parameters, such as SNA, SNB, ANB, MP-FH, N-Me, N-ANS, ANS-Me, joint space measurements, condylar dimensions, lip parameters, including ULP, ULEP, LLEP, Z-angle, upper airway parameters, including Ba-PNS, Ad1-PNS, Ad2-PNS, Mc1Mc2, SPP-SPPW, UMPW, PAS, VLPW, and clinical efficacy were compared between the two groups before and after treatment.</p><p><strong>Results: </strong>After treatment, the study group exhibited significantly higher values in ANB, MP-FH, ANS-Me, joint spaces, condylar mediolateral width, and Z-angle, while showing lower values in N-Me, N-ANS, condylar height, condylar anteroposterior diameter, ULP, ULEP, and LLEP compared to the control group. For upper airway parameters, the study group had higher values in Ad1-PNS, Ad2-PNS, Mc1Mc2, and SPP-SPPW. The study group also demonstrated superior clinical efficacy, achieving a total effective rate of 94.44%.</p><p><strong>Conclusion: </strong>The invisible mandibular advancement appliance demonstrates significant clinical efficacy in treating adolescent skeletal Class II malocclusion, effectively improving TMJ morphology while simultaneously optimizing facial profile and airway function.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102529"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of TP53 and EZH2 with salivary adenoid cystic carcinoma.","authors":"Yongbin Di, Haolei Zhang, Bohao Zhang, Dan Li","doi":"10.1016/j.jormas.2025.102526","DOIUrl":"10.1016/j.jormas.2025.102526","url":null,"abstract":"<p><strong>Background: </strong>Adenoid cystic carcinoma of the salivary gland is a rare salivary gland carcinoma that originates from salivary duct cells and is characterized by local invasion. The relationship between TP53, EZH2 and salivary adenoid cystic carcinoma is still unclear.</p><p><strong>Methods: </strong>Salivary adenoid cystic carcinoma datasets GSE153002 and GSE153283 were downloaded from gene expression omnibus (GEO). Differentially expressed genes (DEGs) were screened. Weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, gene set enrichment analysis (GSEA), construction and analysis of protein protein interaction (PPI) network, Comparative Toxicogenomics Database (CTD) analysis were performed. Gene expression heatmap was drawn. Using RT-qPCR and WB assays to validate the expression of core genes.</p><p><strong>Results: </strong>98 intersection DEGs were obtained. According to Gene Ontology (GO), in Biological Process (BP) analysis, they are primarily enriched in inflammatory response, cell cycle, cell migration. In Cellular Component (CC) analysis, they mainly enrich in protein kinase complex and protein-containing complex. In Molecular Function (MF) analysis, they are concentrated in protein kinase activity and signal receptor binding. In Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, they mainly enrich in cancer pathways, MAPK, P53, PI3K-Akt signaling pathway, transcriptional dysregulation in cancer. Twenty-eight significant modules were identified, core genes (TP53, EZH2) were obtained. The gene expression heatmap reveals high expression of TP53, EZH2 in salivary adenoid cystic carcinoma samples. CTD analysis indicates the association of TP53, EZH2 with salivary gland neoplasms, adenocarcinoma, adenoid cystic carcinoma, and inflammation. Results from RT-qPCR and WB assays showed that TP53 and EZH2 were highly expressed in salivary gland tumor tissues.</p><p><strong>Conclusion: </strong>TP53 and EZH2 are highly expressed in salivary adenoid cystic carcinoma, which may serve as their molecular targets.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102526"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable machine learning for the prognostication of salivary duct carcinoma: Development and deployment of a web-based prediction tool.","authors":"Junxu Chen, Derong Zou, Dongwook Kim, Hyung Jun Kim","doi":"10.1016/j.jormas.2025.102528","DOIUrl":"10.1016/j.jormas.2025.102528","url":null,"abstract":"<p><strong>Background: </strong>Salivary duct carcinoma (SDC) is a rare but aggressive malignancy often associated with lymph node metastasis and poor prognosis. Therefore, although accurate prognostication is crucial, traditional models are often inadequate because of linear assumptions and limited interpretability. In contrast, machine learning (ML) offers a flexible, interpretable framework for improving survival prediction and supporting individualized care planning.</p><p><strong>Method: </strong>Overall, 552 patients with SDC (2004-2021) were identified from the Surveillance, Epidemiology, and End Results database and stratified by cancer-specific survival (CSS) and overall survival (OS) status, before being split into the training and testing sets (7:3). Three prognostic models were developed: Cox proportional hazards, random survival forest (RSF), and DeepSurv. Model performance was evaluated using the concordance index (C-index), integrated Brier score, time-dependent area under the curve (AUC), calibration curves, and decision curve analysis. Shapley additive explanations (SHAP) values were applied to enhance model interpretability and quantify the contribution of individual features to risk prediction.</p><p><strong>Result: </strong>All three models demonstrated favorable predictive performance, with the RSF model showing the best discrimination and calibration (C-index: 0.785 in training and 0.768 in testing). For CSS prediction, the 1-, 3-, and 5-year AUCs in the testing set were 0.781, 0.810, and 0.818, respectively. SHAP analysis identified positive lymph node ratio, TNM stage, and excision surgery as key prognostic predictors. The RSF model was selected for deployment as an interactive web-based tool.</p><p><strong>Conclusion: </strong>This study established an interpretable ML-based model that reliably predicts CSS and OS in patients with SDC. Its successful deployment as a web-based tool underscores its potential to enhance personalized prognostic assessment and support evidence-based clinical management.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102528"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary bone lymphoma: A rare case of mandibular diffuse large B-cell lymphoma in a background of osteomyelitis.","authors":"Océane Mériaux, Eric Lagrue, Marion Morcel, Chloé Antier, Philippe Lesclous","doi":"10.1016/j.jormas.2025.102521","DOIUrl":"10.1016/j.jormas.2025.102521","url":null,"abstract":"<p><p>Primary bone lymphoma is a rare and extra nodal type of non-Hodgkin lymphoma. It accounts for less than 1% of all lymphomas. It can affect various bones, most commonly the femur or humerus. However, it rarely affects the jawbone, especially the mandible. Diffuse large B-cell lymphoma is a subtype of non-Hodgkin lymphoma. This case report describes a 59-year-old woman who presented with worsening swelling of the symphyseal region of the mandible. Initially, she was diagnosed for an acute osteomyelitis in the context of previous periodontitis and treated accordingly. However, the patient did not respond to two courses of amoxicillin therapy. Ultimately, a biopsy revealed diffuse large B-cell lymphoma. The cases's strength lies in its potential to establish a link between local inflammatory disease and the onset of a DBCL. Furthermore, long-term clinical and imaging follow-up has demonstrated a favorable prognosis with standard chemotherapy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102521"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}