Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"LncRNA HNF1A-AS1 inhibits ferroptosis in oral squamous cell carcinoma cells through the miR-124/ PKM2 axis.","authors":"Lu Deng, Qiang Tang, Huiqin Lv, Zhe Liu","doi":"10.1016/j.jormas.2025.102522","DOIUrl":"10.1016/j.jormas.2025.102522","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to illustrate the molecular mechanism of lncRNA HNF1A-AS1 in ferroptosis in OSCC, providing novel therapeutic implications for OSCC treatment.</p><p><strong>Methods: </strong>Human OSCC cell lines (CAL-27, SCC-15, HSC-3, WSU-HN12) and normal human oral keratinocytes (NHOK) were used for in vitro experiments. The function of lncRNA HNF1A-AS1 on ferroptosis in OSCC was evaluated through measurement of cell proliferation, gene expression, protein expression levels, and ferroptosis-related indicators. The binding relationships between miR-124 and HNF1A-AS1, as well as between miR-124 and the 3'UTR of PKM2, were verified using dual-luciferase reporter gene assays and RIP assays. miR-124 inhibition or PKM2 overexpression was combined with silencing of HNF1A-AS1 for functional verification. Statistical analysis was performed to compare changes in the indicators among different treatments.</p><p><strong>Results: </strong>In OSCC cells, HNF1A-AS1 and PKM2 were overexpressed, while miR-124 expression was downregulated. Silencing HNF1A-AS1 suppressed cell proliferation, elevated contents of ROS, MDA and Fe²⁺, reduced GSH content, enhanced ACSL4 expression and diminished GPX4 expression. Mechanistically, HNF1A-AS1 bound to and sequestered miR-124, and miR-124 bound to and inhibited PKM2 expression. Both miR-124 inhibition and PKM2 overexpression partially reversed the promotive effect of HNF1A-AS1 silencing on OSCC cell ferroptosis.</p><p><strong>Conclusion: </strong>HNF1A-AS1 inhibits OSCC cell ferroptosis by binding to miR-124 to relieve the transcriptional inhibition of PKM2. Our study offers a potential therapeutic strategy for OSCC treatment.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102522"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two typical and one atypical presentation of TUGSE: Case series and literature review.","authors":"Mikyung Gong, Min-Ji Kim, Seung-Yong Han, Hyun Sil Kim, Woong Nam","doi":"10.1016/j.jormas.2025.102525","DOIUrl":"10.1016/j.jormas.2025.102525","url":null,"abstract":"<p><strong>Background: </strong>Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare, reactive oral mucosal lesion characterized by dense eosinophilic infiltration. Although often linked to trauma, immune-mediated mechanisms may also contribute. Clinically, TUGSE can mimic malignancy or infection.</p><p><strong>Case presentation: </strong>We report three cases of TUGSE with variable presentations. The first two cases involved classic ulcerative lesions on the lateral tongue, both of which healed spontaneously following biopsy. The third case presented as a deep cold abscess extending from the lingual cortex to the mandibular base following third molar extraction-an uncommon presentation. All lesions were histopathologically diagnosed as TUGSE.</p><p><strong>Conclusion: </strong>These cases demonstrate the clinical spectrum of TUGSE and highlight the importance of early biopsy and histopathological evaluation in persistent oral ulcers to ensure diagnostic accuracy and guide appropriate management. Recognizing atypical presentations may help avoid misdiagnosis and unnecessary interventions.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102525"},"PeriodicalIF":2.0,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding OSCC prognosis: Insights into age-linked patterns and survival dynamics using AJCC 8th edition and CAP protocols.","authors":"Sandhya Sundar, Suganya Paneerseelvam, Pratibha Ramani, Lakshmi Trivandrum Anandapadmanabhan, Ramya Ramadoss","doi":"10.1016/j.jormas.2025.102527","DOIUrl":"10.1016/j.jormas.2025.102527","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) is the most common oral cancer, with rising incidence rates due to several risk factors. In this study, the clinicopathological characteristics and disease-free survival (DFS) of OSCC patients are explored, emphasising age-related prognostic differences. A retrospective analysis was conducted on cases diagnosed in 2022 at an exclusive oral cancer hospital, using the College of American Pathologists (CAP) protocol and AJCC 8th edition staging. Demographic, clinical, and histopathological parameters were compared between patients ≤50 years and >50 years. Among the group, 57.8 % were older than 50 years, with a male predominance. While the younger group had a greater proportion of stage II cancers, the older patients presented more frequently with advanced stage III/IV disease. Lymph node involvement (p = 0.036) and invasion of adjacent structures (p = 0.048) were significantly higher in older patients. Interestingly, the mean depth of invasion (DOI) was greater in younger patients (p = 0.009). There was no discernible difference in DFS or recurrence rates between the groups. Age over 50, lymph node involvement, and DOI were all substantially linked to advanced stage in univariate binary logistic regression. However, in multivariate analysis, only DOI (OR = 1.18; p = 0.002) and nodal status (OR = 4.02; p < 0.001) remained independent predictors, while age lost statistical significance (p = 0.305). The model showed high predictive accuracy (AUC = 0.90). In conclusion, although age correlates with disease extent, DOI and lymph node status are stronger independent predictors, reinforcing the need for personalised risk-based management in OSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102527"},"PeriodicalIF":2.0,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends of teaching methodologies in oral and maxillofacial surgery education: A 30-Year bibliometric analysis.","authors":"Youming Luo, Yilin She, Zhen Li, Nan Jiang","doi":"10.1016/j.jormas.2025.102523","DOIUrl":"10.1016/j.jormas.2025.102523","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze 30-year global trends in Oral and Maxillofacial Surgery(OMS) education research through bibliometrics, assessing publication patterns, key contributors, and emerging teaching methodologies.</p><p><strong>Methods: </strong>The study analyzed publications on teaching methodologies in oral and maxillofacial surgery within the Web of Science Core Collection, covering the period from 1994 to 2024. A systematic compilation methodology was employed, including rigorous literature retrieval with specific inclusion and exclusion criteria, data cleaning using CiteSpace software to eliminate redundant entries, and comprehensive analysis using multiple tools such as Microsoft Excel for data management, Bibliometric Online Analysis Platform for inter-country collaboration visualization, R software for geospatial data visualization, CiteSpace for constructing visual networks of various elements, and Origin for annual publication analysis. Using these tools, we conducted a bibliometric analysis and visualization of teaching methodologies in this surgical field.</p><p><strong>Results: </strong>The number of relevant publications in this research area demonstrates a fluctuating yet overall upward trend, totaling 248 articles and 15 reviews. These contributions originate from 37 countries, 41 institutions, and involve 1,306 authors. The USA, UK, and Germany are the leading contributors. Most articles were published in the \"Journal of Oral and Maxillofacial Surgery.\" Key authors include Robert Sader, Lukas B. Seifert, and Jasmina Sterz, while Frank Hoelzle has the most influence. The predominant keywords are \"skills,\" \"experience,\" and \"competence.\"</p><p><strong>Conclusion: </strong>The bibliometric analysis of oral and maxillofacial surgery education highlights a dynamic field with a rising global scholarly interest. The USA, UK, and Germany lead in research contributions, and diverse teaching methods, from traditional lectures to cutting-edge simulations, -playing a crucial role in student development. Despite the challenges, such as resource constraints and the need for technological advancement, the integration of these methods and the adoption of innovative technologies are pivotal for advancing OMS education. This comprehensive approach is essential for equipping future surgeons with the competencies required to thrive in the complex and evolving field of oral and maxillofacial surgery.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102523"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of persistent pain and overall quality of life after temporomandibular joint replacement.","authors":"Bernardo Correia Lima, Bruno Alvarez Quinta Reis, Leonardo Brigido Metello Neves, Ricardo Grillo, Mariana Aparecida Brozoski, Fernando Melhem-Elias","doi":"10.1016/j.jormas.2025.102524","DOIUrl":"10.1016/j.jormas.2025.102524","url":null,"abstract":"<p><strong>Objective: </strong>Temporomandibular joint disorders (TMD) sheds light on the multifaceted nature of conditions affecting the jaw joint and surrounding structures, which significantly impairs overall quality of life (OQoL). In addressing end-stage TMD, temporomandibular alloplastic total joint replacement (TMJR) surgery has emerged as a viable intervention, offering the potential for improved OQoL, reduced pain, and enhanced oral function and mandibular form. Custom TMJR devices have gained prominence due to their ability to mimic natural joint anatomy, optimizing functional outcomes and reducing complications.</p><p><strong>Study design: </strong>This study intended to make a narrative review of literature over chronic pain post-TMJR and overall quality of life.</p><p><strong>Results: </strong>A total of 37 articles were identified that met the screening criteria, with a total of 1194 patients evaluated, with a mean of post-TMJR follow-up of 54.66 months. Psychological factors, such as catastrophizing and depression, play significant roles in pain persistence, emphasizing the importance of holistic patient care. Additionally, extrinsic factors like prior misdiagnosis and complex regional pain syndrome contribute to postoperative pain, necessitating comprehensive management approaches.</p><p><strong>Conclusions: </strong>Despite challenges, long-term studies consistently highlight the successful outcomes of TMJR surgeries, underscoring the need for continued research to optimize outcomes and enhance patient well-being.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102524"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instant loading of a prefabricated definitive zirconia prosthesis in an all-on-four rehabilitation with pterygoid implants using the full-arch surgery technique protocol.","authors":"Solène Chanteux, Rémi Lafon, Roxane Gares, Dimitri Pascual","doi":"10.1016/j.jormas.2025.102518","DOIUrl":"10.1016/j.jormas.2025.102518","url":null,"abstract":"<p><strong>Introduction: </strong>Immediate rehabilitation of severely atrophic maxillae is often complicated by the need for extensive surgical procedures, such as zygomatic or subperiosteal implants, when conventional techniques are no longer feasible. Incorporating pterygoid implants into the All-on-Four concept offers an attractive alternative by leveraging the dense cortical bone of the pterygomaxillary complex while eliminating posterior cantilevers.</p><p><strong>Technical note: </strong>Building upon the Full-Arch Surgery Technique (FAST) approach, we present an innovating protocol that combines guided implant placement with instant loading of a prefabricated zirconia definitive prosthesis in a single surgical session. Rigorous digital planning, the use of rigid metal surgical guides, and low-speed drilling techniques contribute to surgical accuracy and predictable prosthetic outcomes. In our initial experience with 11 patients, all pterygoid implants remained functional at 15 months. One prosthetic fracture occurred and was successfully managed.</p><p><strong>Conclusion: </strong>This protocol reduces morbidity, avoids complex and multiple surgeries (grafts, zygomatic implants, or delayed steps) and offers a reliable, efficient solution for fixed rehabilitation of atrophic maxillae.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102518"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Burden of Orofacial Clefts (1990-2021): Trends, inequalities and prediction to 2040.","authors":"Zhiyan Wang, Yuanxi Luo, Zhichao Zhai, Tao Song","doi":"10.1016/j.jormas.2025.102517","DOIUrl":"10.1016/j.jormas.2025.102517","url":null,"abstract":"<p><strong>Background: </strong>Orofacial clefts (OFCs) are prevalent congenital anomalies, affecting approximately 1 in 700 live births globally. Despite surgical advancements reducing mortality, individuals face lifelong challenges.</p><p><strong>Methods: </strong>We analyzed Global Burden of Disease (GBD) data (1990-2021) across 204 countries and territories, focusing on age-standardized incidence, disability-adjusted life years (DALYs), and mortality. Joinpoint regression identified temporal trends, spatial analysis with Getis-Ord Gi* statistics mapped hotspots, and health inequality was evaluated using Slope Index of Inequality and Concentration Index. Autoregressive Integrated Moving Average models projected burden to 2040.</p><p><strong>Results: </strong>Global age-standardized incidence dropped from 3.80 to 2.96 per 100,000, with DALYs decreasing from 20.78 to 5.78 per 100,000 and mortality from 0.19 to 0.028 per 100,000. Low Socio-demographic Index regions had the highest 2021 DALY rate (8.65 per 100,000) compared to 2.23 in high Socio-demographic Index areas, with hotspots in Central Asia and the Horn of Africa. Absolute disparities worsened (Slope Index of Inequality:3.61 to -7.52), though relative inequality improved (Concentration Index: 0.192 to 0.147). By 2040, incidence is projected to fall to 2.25 per 100,000.</p><p><strong>Discussion: </strong>Despite a global reduction in OFCs burden, socioeconomic disparities remain pronounced. Targeted interventions in hotspot regions and equitable healthcare strategies are essential to address persistent inequalities.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102517"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parotidectomy in outpatient surgery: Retrospective analysis of selection criteria.","authors":"Xavier Vanden Eynden, Koyenzi Lebikaza, Antoine Yanni, Alexandra Rodriguez, Cyril Bouland, Rokneddine Javadian, Edward Boutremans, Didier Dequanter","doi":"10.1016/j.jormas.2025.102516","DOIUrl":"10.1016/j.jormas.2025.102516","url":null,"abstract":"<p><strong>Objective: </strong>Outpatient surgery is in full expansion, because it allows hospital resources to be optimized. Although parotidectomy, often performed in hospital, it is possible to perform this procedure on an outpatient basis thanks to recent advances, but a rigorous selection of patients is necessary. This study aims to evaluate the results of conventional parotidectomies, analyze postoperative complications and propose criteria to identify patients suitable for outpatient care.</p><p><strong>Methods: </strong>After approval by the ethics committee, this retrospective study included 90 patients who underwent parotidectomy between January 2018 and September 2024. The variables analyzed included demographic, clinical, operative and postoperative data. Statistical analyses were performed with IBM® SPSS®, using appropriate tests (Shapiro-Wilk, Mann-Whitney, Student, Chi-square) according to the data, with a significance threshold set at p < 0.05.</p><p><strong>Results: </strong>The study included 90 patients who underwent parotidectomy, mostly partial (90 %). Tumors were benign in 90 % of cases, with a mean size of 2.5 cm. The median operative time was 132.5 min, and 72.2 % of patients had a hospital stay of ≤ 2 days. A significant association was observed between operative time ≥ 120 min and prolonged hospital stay (p < 0.001). Quantities drained (≥ 30 mL for 86.7 % of patients) were related to longer operative time, but without correlation with comorbidities, tumor size or malignancy. No significant association was established with postoperative complications.</p><p><strong>Conclusions: </strong>Ambulatory parotidectomy offers advantages, but requires rigorous patient selection, based on well-defined factors such as tumor size, histological type and operating time. In outpatient surgery, post-operative monitoring is essential to ensure the success of the procedure.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102516"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Custom 3D-printed decompression valve with protective cap for managing large mandibular lesion.","authors":"Lázaro da Silva Caixeta Neto, Bruno Alvarez Quinta Reis, Ricardo Grillo, Fernando Melhem-Elias","doi":"10.1016/j.jormas.2025.102515","DOIUrl":"10.1016/j.jormas.2025.102515","url":null,"abstract":"<p><strong>Objectives: </strong>Decompression is a well-established technique for managing large cysts, aiming to reduce osmotic pressure and lesion size, thereby facilitating subsequent surgical intervention with reduced risk and avoiding extensive maxillofacial reconstructions. This technical note presents a custom-designed decompression valve with a protective cap to address common challenges in traditional decompression techniques.</p><p><strong>Technical note: </strong>A 24-year-old male presented with facial swelling, significant edema in the left mandibular region, and an osteolytic lesion identified via CT scan. The lesion was hypothesized to be an odontogenic cyst. A two-stage surgical approach was implemented. The first stage involved biopsy and placement of a custom-designed decompression valve. Using 3D Slicer® and Blender ® software, a patient-specific valve was fabricated with four suture holes for secure placement and a screwable protective cap to prevent foreign material ingress and facilitate irrigation. The valve was 3D-printed using Poly-Lactic-Acid (PLA). Post-procedure, the diagnosis was confirmed as an odontogenic keratocyst. The valve remains in place, awaiting sufficient lesion size reduction before proceeding with the second surgical stage.</p><p><strong>Conclusion: </strong>The described custom decompression valve represents an innovative, patient-centered approach that enhances traditional decompression techniques. Its accessibility, affordability, and effectiveness make it a valuable tool in managing large odontogenic cysts, especially in resource-constrained environments. Further studies may explore broader applications and long-term outcomes of this technology.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102515"},"PeriodicalIF":2.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive elastin-like-recombinamer (ELR) membranes guide bone regeneration in rabbit critical size calvarial defects.","authors":"Vasiliki P Koidou, Shakeel Shahdad, Mital Patel, Stuart Lanham, Shaun Peggrem, Richard Oreffo, José Carlos Rodriguez-Cabello, Alvaro Mata, Sherif Elsharkawy","doi":"10.1016/j.jormas.2025.102514","DOIUrl":"10.1016/j.jormas.2025.102514","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the effectiveness of non-mineralised and pre-mineralised elastin-like recombinamer (ELR) membranes in guided bone regeneration (GBR) in a pre-clinical rabbit model.</p><p><strong>Materials and methods: </strong>Three pre-mineralised ELR membranes (D1, D2 and D8) and a non-mineralised (D0) membrane, along with a collagen membrane (C+) and an empty defect were randomly allocated in rabbit calvarial defects of critical size. Four weeks post-implantation the animals were euthanized and bone fill was assessed using micro CT and histological evaluation.</p><p><strong>Results: </strong>Using micro CT, all ELR membranes led to similar bone density, as unassisted healing and healing using a resorbable collagen membrane. A trend for superior bone fill with the D2 pre-mineralised ELR membrane was observed. Histologically, at this early time-point the ELR membranes successfully guided GBR in the defects, similarly to the control collagen membrane, and additionally led to the formation of a thin woven bone layer at the top of the cranial defect bridging between the margins of the defect.</p><p><strong>Conclusions: </strong>As early as 4 weeks post-implantation, the ELR membranes successfully guided bone regeneration in this rabbit critical size calvarial model and a trend for superior regeneration was observed with pre-mineralised for 2 days ELR membranes. The ELR membranes led to the formation of a bony bridge parallel to the membrane suggesting bioactivity beyond occlusion of the defect.</p><p><strong>Clinical relevance: </strong>These bioactive alloplastic membranes may succesfully serve as alternatives to allogenic membranes in guided bone regeneration.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102514"},"PeriodicalIF":2.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}