Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Optimal age for mandibular distraction osteogenesis in craniofacial microsomia: A systematic review and meta-analysis.","authors":"Chen Li, Anna Liu, Wei Liu, Xiaojun Tang","doi":"10.1016/j.jormas.2025.102255","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102255","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to determine the optimal timing for mandibular distraction osteogenesis in children with craniofacial microsomia based on long-term outcomes and relapse rates.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science was conducted for studies published up to September 2024. Eligible studies included children aged ≤16 years with CFM who underwent MDO, with follow-up duration exceeding one year. The included population was divided into two groups based on age: children younger than 6 years and those aged 6-16 years. The primary outcome was the relapse rate measured by ramus height ratio, and secondary outcome was occlusal cant. Statistical analyses included heterogeneity assessment, random-effects modeling, and subgroup analysis based on follow-up duration.</p><p><strong>Results: </strong>Ten studies, comprising 175 patients, were included. The pooled relapse rate based on ramus height ratio was 67.8% (CI: 35.8-93.4%) for children under 6 years and 72.5% (CI: 10.5-94.4%) for those aged 6 years or older, with no statistically significant difference. Subgroup analysis showed that relapse rates increased significantly after five years of follow-up, suggesting progressive asymmetry due to slower growth on the affected side. When occlusal cant was used as a metric, higher relapse rates were observed in children over 6 years 95.6% (CI: 28.9-65.1%) compared to younger patients 46.8% (CI: 83.9-100%).</p><p><strong>Conclusions: </strong>Despite early MDO providing psychosocial and developmental benefits, relapse rates remain high across all age groups, complicating the determination of an optimal timing. Long-term monitoring, individualized treatment plans, and refined severity grading systems are essential for improving outcomes in CFM patients. Future research should include standardized methodologies, larger groups, and advanced imaging techniques to optimize treatment strategies.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102255"},"PeriodicalIF":2.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which is the fastest and safest approach? A comparison of time and complications of transparotid and anteroparotid retromandibular approach in management of mandibular subcondylar fractures: A prospective randomized controlled trial.","authors":"Pareeksit Bagchi, Sunil Sidana, Padmakar Baviskar, Srivalli Natarajan, Suraj Ahuja, Ruchita Balkawade","doi":"10.1016/j.jormas.2025.102235","DOIUrl":"10.1016/j.jormas.2025.102235","url":null,"abstract":"<p><strong>Introduction: </strong>Mandibular condylar fractures are among the most common facial fractures and its incidence has been rising since the past few decades. Although various approaches for management of mandibular condylar fractures have been described in literature there is a gap in the published literature when it comes to comparison of these approaches. There have only been a handful of studies which have compared use of Retromandibular Transparotid against Retromandibular anteroparotid approach in management of mandibular condylar fractures with conflicting results. The aim of this study was to aid in decision making regarding the choice of approach between the Retromandibular Transparotid and Anteroparotid Transmasseteric approach based on the ease of surgical access and incidence of complications.</p><p><strong>Materials and methods: </strong>A total of 24 patients were registered in the study under two treatment groups, Transparotid (Group A) and Anteroparotid (Group B). Data collection was done by a single blinded observer for measurement of exposure time, facial nerve weakness, facial oedema, presence of a sialocele, presence of a parotid fistula (and presence of various complications).</p><p><strong>Results: </strong>The average time required for exposure of fracture site in group A was 11 min ± 2.73 min and in group B was 9 min ±1.91 min. Facial nerve injury (Grade III House Brackmann scale) was noted in one patient in group A. There was no significant difference in quality of reduction, occlusion and mandibular mobility.</p><p><strong>Conclusion: </strong>The results of this study indicate that the rate of complications and time required to access the fracture site was comparable in both the approaches. It can be said that both the anteroparotid and transparotid approaches are reasonably safe and convenient in management of mandibular condylar fractures.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102235"},"PeriodicalIF":2.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of anterolateral thigh flap from polio-affected lower limb: A safe surgical option that preserves patient's motor function.","authors":"Zi-Jie Yuan, Lei Chen, Xiao-Xia Cheng, Xing-Chi Liu, Liang Mao, Jing Li, Zi-Li Yu, Jun Jia","doi":"10.1016/j.jormas.2025.102233","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102233","url":null,"abstract":"<p><p>The anterolateral thigh (ALT) flap is a commonly used donor site for reconstructive surger, especially in head and neck reconstructions. The flap's success is primarily determined by the quality and quantity of its perforating vessels, which is why clinicians typically prefer harvesting from a healthy leg with intact vascular anatomy. Poliomyelitis typically causes unilateral lower limb paralysis, resulting in muscle atrophy and deformities. Harvesting the ALT flap from the paralyzed leg could preserve the function of the unaffected limb, but this approach is complicated by the atrophy and deformities present in the affected leg, creating substantial challenges. We here report the successful ALT flap harvesting from the polio-affected leg in a 55-year-old male patient for the reconstruction of a tongue defect. The patient diagnosed with Left tongue squamous cell carcinoma, and underwent tongue cancer excision and a modified radical neck dissection. The flap survived and healed well with the patient's tongue tissue. The wound at the donor site on the thigh also healed well. There were no complications observed in either the flap or the donor site. Our experience suggests that harvesting from the paralyzed leg is a safe and feasible procedure that preserves the function of the unaffected limb and may enhance the postoperative quality of life for polio survivors.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102233"},"PeriodicalIF":2.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Y-shaped venous anastomosis combined with free flap for the treatment of complex craniofacial trauma.","authors":"Chenglan Yang, Lingli Jiang, Dapeng Zhou, Qi Wang, Zairong Wei","doi":"10.1016/j.jormas.2024.102203","DOIUrl":"https://doi.org/10.1016/j.jormas.2024.102203","url":null,"abstract":"<p><strong>Background: </strong>Complex craniofacial trauma is defined as those traumatic injuries that are not responding to initial treatment and may involve chronic infection, tissue exposure, and soft tissue contusions. Typical reconstruction using a Y-shaped microvascular venous anastomotic free flap is labor intensive. Although free flap grafts have been used in many applications, their use for combined microvascular anastomotic therapy remains an unexplored but attractive possibility.</p><p><strong>Purpose: </strong>Correcting facial contour trauma is challenging because it requires careful planning of flap design, composition, and ancillary procedures METHODS: This study analyzed a retrospective cohort of 28 craniofacial trauma patients (18 males; 10 females) who underwent Y-shaped microvascular venous anastomosis free flap grafting for treatment of the defects between January 2020 and January 2022, and were followed up for more than 6 months after the procedure.</p><p><strong>Results: </strong>The causes of defects were high-voltage electrical injuries (n = 12), after excision of scalp malignant tumors (n = 8), grade III burns (n = 6), and trauma (n = 2). By adjusting the height of the tissue and the different tissue components, the flaps were designed in three dimensions by contour mapping so that they had different thicknesses depending on the defect. Custom-sized flaps with a reliable envelope were taken while minimizing the loss of overlying skin. 6 flaps were based on two perforators, and another 19 were based on one perforator. Nine flaps were harvested in an inlay fashion. All flaps were fully viable and no donor lesions were present in any case. Contour and symmetry were improved in all patients, and all grafted patients were evaluated for pre- and postoperative aesthetic restoration.</p><p><strong>Conclusions: </strong>Our findings suggest that the Y-shaped microvascular venous anastomosis free flap approach may be a reliable alternative for aesthetic reconstruction of facial contour trauma.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102203"},"PeriodicalIF":2.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the guide hole height on the accuracy of implant placement: An in-vitro study.","authors":"Soohyeon Kim, Jin-Yong Cho, Jaeyoung Ryu","doi":"10.1016/j.jormas.2025.102232","DOIUrl":"https://doi.org/10.1016/j.jormas.2025.102232","url":null,"abstract":"<p><strong>Objective: </strong>Guided implant surgery using three-dimensional (3-D) planning software and 3-D printed surgical guides has become a critical tool for enhancing accuracy. This study aims to determine the minimum guide hole height necessary to maintain implant placement accuracy.</p><p><strong>Materials and methods: </strong>Ten maxillary models with edentulous areas were created using CT and optical scan data. Six sites (for each model) were prepared for implant placement with surgical guides fabricated using a 3-D printer. Sixty implants were placed using these guides and divided into five groups according to the guide hole height (1 to 5 mm). After the placement, digital impressions were taken to assess the accuracy of implant positioning. Deviations between planned and actual implant positions were investigated using computer software, and data were statistically analyzed using ANOVA and Kruskal-Wallis tests.</p><p><strong>Results: </strong>Guide holes with 1 mm height (Group Ⅰ) resulted in the highest 3-D deviations (1.12 ± 0.36 and 1.99 ± 0.74 mm at the coronal and apical positions, respectively), with significant errors at the implant apical position compared to groups with taller guide holes (Groups Ⅳ and Ⅴ) (p = 0.005). There were no significant deviations between the 3 mm and 5 mm guide hole heights, with no statistical differences between groups at the x, y, and z-axis in the implant position.</p><p><strong>Conclusion: </strong>A comparison between the group with a guide hole height of 5 mm on one side and the group with a height of 1 mm on both sides revealed a significant difference in implant placement accuracy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102232"},"PeriodicalIF":2.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic preconditioning in arterialized venous flap: Temperature effects and monitoring.","authors":"Rani Septrina, Ronny Lesmana, Reno Rudiman, Rizky Abdullah, Irra R Widarda, Ita N Kusmayadi, Stevy C Suoth, Caroline Dewi","doi":"10.1016/j.jormas.2025.102231","DOIUrl":"10.1016/j.jormas.2025.102231","url":null,"abstract":"<p><strong>Introduction: </strong>Arterialized venous flap, like any other flap, will undergo an ischemic reperfusion injury during its transfer process. To overcome this, ischemic preconditioning can be done to provide protection and enhanced flap survival. One of the reliable parameters of flap survival is its temperature. However, there was no recorded data regarding AVF's temperature or its monitoring. This research aimed to demonstrate the temperature effect of ischemic preconditioning on arterialized venous flap.</p><p><strong>Method: </strong>Male Wistar Rats were randomly divided into 4 groups, consisting of 6 negative control groups, 8 positive control group (PS) rats that underwent an anastomosis of the superficial epigastric artery to the superficial epigastric vein, 8 experimental rat group 1 (EX1) that underwent 3 cycles of 5 minutes pre-anastomosis clamping with 3 cycles of 5 minutes each, and 8 experimental rats' group 2 (EX2) with 3 cycles of 10 minutes. Flap's temperature was observed preoperatively and postoperatively from day 1 to day 7, day 14, and day 21 with an android-based thermal camera and recorded in Celsius degrees.</p><p><strong>Results: </strong>All the flaps (N= 26) were vital. The temperature drop was seen in all anastomosed flaps compared to the negative control (30.37 vs. 25.08 vs. 23.77 vs. 25.27, p<0.05). A significant increase in temperature occurred on days 4 to 6 in Ex1 (33.62±1.820, 33.62±1.820, 32.40±1.627; p<0.05). As in the temperature trend, Ex2 is shown to have a stable temperature from day 2 until 21.</p><p><strong>Conclusion: </strong>This study has recorded an increase in temperature in the early days of the creation of the arterialized venous flap at various timings of ischemic preconditioning. The flap's monitoring was easily observed with a thermal camera that can be implemented in humans.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102231"},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictor of diplopia in pure orbital blowout fracture: A 14-year retrospective analysis.","authors":"Mohd Ferdaus Isa, Abd Jabar Nazimi, Roszalina Ramli","doi":"10.1016/j.jormas.2025.102230","DOIUrl":"10.1016/j.jormas.2025.102230","url":null,"abstract":"<p><strong>Introduction: </strong>Orbital fractures are common among maxillofacial injuries. The primary objective of this study was to investigate the clinical and radiographic characteristics of pure orbital blowout fractures (OBFs) and their association with post-traumatic diplopia. The secondary objective was to identify predictors of diplopia in pure OBFs.</p><p><strong>Method: </strong>This retrospective cross-sectional study analysed the clinical records and computed tomography (CT) data of patients with pure OBFs, treated between 1st January 2008 and 28th February 2022 at a single tertiary trauma centre in Klang Valley, Kuala Lumpur, Malaysia. Data collected included demographic characteristics and the aetiology of OBFs. Specific factors such as fracture site, size, type, and soft tissue involvement were assessed using CT images, which were converted to DICOM format and analysed with the OsiriX v4.1.2 software. Diplopia was measured using the Hess area ratio percentage (HAR%).</p><p><strong>Results: </strong>The analysis included records of 70 patients. Motor vehicle accidents (MVAs) accounted for 61.4 % of pure OBFs. The largest fracture observed involved both the orbital floor and the medial wall, with a mean size of 6.40 ± 3.05 cm². Among the patients, 41.6 % had Type 3 fractures, and 50 % (n = 35) had 2-point muscle-soft tissue contact. Fracture size, site, type, and muscle contact were all significantly associated with HAR92 % (p < 0.05). Logistic regression revealed that Type 3 fracture was the significant predictor of diplopia (HAR < 92 %), with an odds ratio of 19.80 (95 % CI: 5.76-68.07, p < 0.001).</p><p><strong>Conclusion: </strong>Fracture site, size, type, and muscle involvement were important factors associated with diplopia. Among these, Type 3 fractures were identified as the primary predictor of HAR < 92 %.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102230"},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"HAT-TRICK\" technique: A modification of soft tissue grafting using volume stable collagen matrix and cross-linked hyaluronic acid. Part B: Clinical applications in the esthetic zone.","authors":"Bachar Husseini, Anton Friedmann, Marwan El Mobadder, Nabil Ghosn, Karim Senni, Ranim Abou Chakra, Patrick El Sayegh, Ronald Younes","doi":"10.1016/j.jormas.2025.102229","DOIUrl":"10.1016/j.jormas.2025.102229","url":null,"abstract":"<p><p>Soft tissue deficiency around dental implants can negatively impact outcomes in terms of esthetics and long-term stability. While autogenous connective tissue grafting is still considered the gold standard treatment, alternative approaches are being proposed primarily to enhance patient comfort and avoid invasive procedures such as two-sites surgeries using xenogeneic collagen matrices. Despite the advantages, the quality of the regenerated tissues remains unpredictable and, in many cases, questionable, highlighting the need for alternative and innovative approaches. After introducing in a previous technical note, the \"HAT-TRICK\" technique, to address these challenges in pontic sites, the present study highlights the \"HAT-TRICK\" technique for thickening the keratinized gingiva in both immediate and delayed implant placement sites within the esthetic zone. The \"HAT-TRICK\" technique is demonstrated through two clinical cases, accompanied by a digital comparison conducted at baseline and after one year of follow-up in order to assess and quantify the augmented areas.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102229"},"PeriodicalIF":2.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the greater palatine foramen, the greater palatine artery, and palatal fibromucosa: A cross-sectional ultrasonographic clinical study.","authors":"Kubra Torenek Agirman, Fatma Caglayan","doi":"10.1016/j.jormas.2025.102228","DOIUrl":"10.1016/j.jormas.2025.102228","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate with ultrasonography (US) the location of GPF, the course of the GPA, and to measure palatal fibromucosa thickness.</p><p><strong>Materials and methods: </strong>This in vivo experiment was conducted on a group of healthy, young Turkish subjects. Using the US, the localization of the GPF, its diameter and opening type, maximum flow velocity (Vmax) and collateral branches (CB) of the GPA, and the thickness of the palatine mucosa were evaluated. The distance between the probe and the gingival margin (GM-P) was also measured to determine the course of GPA. Statistical analyses were performed using the chi-square test and the independent sample t-test, with the significance level set at 0.05.</p><p><strong>Results: </strong>The study included 31 participants (16 females, 15 males; mean age, 23.77±0.92). GPF predominantly showed between the second and third molars (n = 15;48.4 %) and exhibited an anterior opening type(n = 25;80.6 %). The average diameter of GPF measured 5.52±1.76 mm, with a Vmax value of GPA at 14.39±5.07 cm/sec. Collateral branches were primarily observed at the first molar level (n = 23; 74.2 %). No statistically significant gender differences were noted in localization or opening type. However, GM-P at the second molar level was significantly greater in men than women(p < 0.05).</p><p><strong>Conclusion: </strong>In understanding the anatomical structure of the palate, the US provides important clinical results regarding the anatomical measurement of the GPF, the GPA, and adjacent fibromucosa.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102228"},"PeriodicalIF":2.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the repair function of radiation-induced salivary gland injury using human amniotic mesenchymal stem cells pre treated with hypoxia.","authors":"Yingxin Wang, Nana Liu, Xin Zhang, Min Dai, Nini Zhang, Guilin Huang","doi":"10.1016/j.jormas.2025.102223","DOIUrl":"10.1016/j.jormas.2025.102223","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the reparative effect of hypoxia pretreated hAMSCs on radiation-induced damage to salivary gland function in mice.</p><p><strong>Methods: </strong>hAMSCs were separated from human amniotic tissues by mechanical and enzymatic digestion methods and a 15 Gy electron beam was used to locally irradiate the neck of mouse to create a salivary gland injury model. The mouse models were randomly divided into four groups: control group, IR+PBS group, IR+Nor group and IR+HP group.</p><p><strong>Result: </strong>Two months after hAMSCs injection, the saliva flow of mice in the IR+PBS group was significantly lower than that of the control group (P < 0.05). The saliva flow of mice in the IR+Nor group and IR+HP group were significantly increased compared to the IR+PBS group (P < 0.05). The cell apoptosis rate of the IR+PBS group was sensibly higher than that of the blank control group (P < 0.05). The cell apoptosis rates of the IR+Nor group and the IR+HP group were lower than that of the IR+PBS group. In addition, the apoptosis rate of the IR+HP group was lower than that of the IR+Nor group (P < 0.05). The changes of IOD of α-Amy in each group showed that the expression of α - Amy in the IR+PBS group was significantly lower than that in the blank control group (P < 0.05). Compared with the IR+PBS group, the IR+Nor group and the IR+HP group showed an obvious increase in the expression of α-Amy (P < 0.05).</p><p><strong>Conclusion: </strong>Low oxygen pretreatment of hAMSCs could more effectively repair the function of radiation-induced salivary gland compared to normoxic cultivation.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102223"},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}