Two typical and one atypical presentation of TUGSE: Case series and literature review.

IF 2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-08-10 DOI:10.1016/j.jormas.2025.102525

Mikyung Gong, Min-Ji Kim, Seung-Yong Han, Hyun Sil Kim, Woong Nam

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引用次数: 0

Abstract

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare, reactive oral mucosal lesion characterized by dense eosinophilic infiltration. Although often linked to trauma, immune-mediated mechanisms may also contribute. Clinically, TUGSE can mimic malignancy or infection.

Case presentation: We report three cases of TUGSE with variable presentations. The first two cases involved classic ulcerative lesions on the lateral tongue, both of which healed spontaneously following biopsy. The third case presented as a deep cold abscess extending from the lingual cortex to the mandibular base following third molar extraction-an uncommon presentation. All lesions were histopathologically diagnosed as TUGSE.

Conclusion: These cases demonstrate the clinical spectrum of TUGSE and highlight the importance of early biopsy and histopathological evaluation in persistent oral ulcers to ensure diagnostic accuracy and guide appropriate management. Recognizing atypical presentations may help avoid misdiagnosis and unnecessary interventions.

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TUGSE的两种典型和一种非典型表现：病例系列和文献综述。

背景：创伤性溃疡性肉芽肿伴间质嗜酸性粒细胞增多（TUGSE）是一种罕见的反应性口腔黏膜病变，其特征是密集的嗜酸性粒细胞浸润。虽然通常与创伤有关，但免疫介导的机制也可能起作用。临床上，TUGSE可模拟恶性肿瘤或感染。病例表现：我们报告三例不同表现的TUGSE病例。前两个病例涉及舌侧的典型溃疡性病变，两者在活检后自发愈合。第三个病例表现为深冷脓肿，从舌皮质延伸到下颌基部，这是一个不寻常的表现。所有病变经组织病理学诊断为TUGSE。结论：这些病例展示了TUGSE的临床特征，强调了早期活检和组织病理学评估对持续性口腔溃疡的重要性，以确保诊断的准确性和指导适当的治疗。识别非典型表现可能有助于避免误诊和不必要的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.