Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao
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Cox proportional-hazards regression was applied to identify factors influencing overall survival (OS).</p><p><strong>Results: </strong>A total of 143 pediatric HNSCC cases were identified, with an average age of 15.4 years at diagnosis and a predominance of male patients (65 %). Tumor distribution was nearly equal between the oral cavity (46.8 %) and the nasopharynx (53.2 %). Nasopharyngeal HNSCC was associated with significantly better overall survival compared to oral cavity HNSCC (p = 0.017). Surgical treatment notably improved survival in oral cavity HNSCC cases (p = 0.022). Cox regression analysis revealed tumor site and chemotherapy as independent predictors of survival.</p><p><strong>Conclusions: </strong>Pediatric HNSCC is a rare condition with diverse survival outcomes based on tumor location. Our study highlights the effectiveness of surgical treatment for oral cavity HNSCC and underscores the importance of tumor site in prognostic assessments for overall survival.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102501"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Survival outcomes and prognostic factors in pediatric head and neck squamous cell carcinoma: A population-based study.\",\"authors\":\"Chaojiao Guan, Fengping Meng, Aifen Chen, Ying Yao\",\"doi\":\"10.1016/j.jormas.2025.102501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This population-based cohort study aimed to offer a thorough analysis of head and neck squamous cell carcinoma (HNSCC) in pediatric and adolescent populations.</p><p><strong>Methods: </strong>We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) program, covering the period from 2000 to 2020. We included cases of primary HNSCC in patients aged 0-19 years with documented causes of death. Survival analysis was conducted using Kaplan-Meier methods, and differences in survival rates were assessed with the log-rank test. Cox proportional-hazards regression was applied to identify factors influencing overall survival (OS).</p><p><strong>Results: </strong>A total of 143 pediatric HNSCC cases were identified, with an average age of 15.4 years at diagnosis and a predominance of male patients (65 %). Tumor distribution was nearly equal between the oral cavity (46.8 %) and the nasopharynx (53.2 %). Nasopharyngeal HNSCC was associated with significantly better overall survival compared to oral cavity HNSCC (p = 0.017). Surgical treatment notably improved survival in oral cavity HNSCC cases (p = 0.022). Cox regression analysis revealed tumor site and chemotherapy as independent predictors of survival.</p><p><strong>Conclusions: </strong>Pediatric HNSCC is a rare condition with diverse survival outcomes based on tumor location. Our study highlights the effectiveness of surgical treatment for oral cavity HNSCC and underscores the importance of tumor site in prognostic assessments for overall survival.</p><p><strong>Level of evidence: 3: </strong></p>\",\"PeriodicalId\":56038,\"journal\":{\"name\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"volume\":\" \",\"pages\":\"102501\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jormas.2025.102501\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology Oral and Maxillofacial Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jormas.2025.102501","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
Survival outcomes and prognostic factors in pediatric head and neck squamous cell carcinoma: A population-based study.
Objective: This population-based cohort study aimed to offer a thorough analysis of head and neck squamous cell carcinoma (HNSCC) in pediatric and adolescent populations.
Methods: We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) program, covering the period from 2000 to 2020. We included cases of primary HNSCC in patients aged 0-19 years with documented causes of death. Survival analysis was conducted using Kaplan-Meier methods, and differences in survival rates were assessed with the log-rank test. Cox proportional-hazards regression was applied to identify factors influencing overall survival (OS).
Results: A total of 143 pediatric HNSCC cases were identified, with an average age of 15.4 years at diagnosis and a predominance of male patients (65 %). Tumor distribution was nearly equal between the oral cavity (46.8 %) and the nasopharynx (53.2 %). Nasopharyngeal HNSCC was associated with significantly better overall survival compared to oral cavity HNSCC (p = 0.017). Surgical treatment notably improved survival in oral cavity HNSCC cases (p = 0.022). Cox regression analysis revealed tumor site and chemotherapy as independent predictors of survival.
Conclusions: Pediatric HNSCC is a rare condition with diverse survival outcomes based on tumor location. Our study highlights the effectiveness of surgical treatment for oral cavity HNSCC and underscores the importance of tumor site in prognostic assessments for overall survival.
期刊介绍：
J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics.
Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.
All manuscripts submitted to the journal are subjected to peer review by international experts, and must:
Be written in excellent English, clear and easy to understand, precise and concise;
Bring new, interesting, valid information - and improve clinical care or guide future research;
Be solely the work of the author(s) stated;
Not have been previously published elsewhere and not be under consideration by another journal;
Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed.
Under no circumstances does the journal guarantee publication before the editorial board makes its final decision.
The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.
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