{"title":"长链非编码RNA作为口腔鳞状细胞癌的潜在诊断生物标志物：一项系统综述和荟萃分析。","authors":"Xingyu Liu, Jing Qiao, Han Qin","doi":"10.1016/j.jormas.2025.102581","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to assess the diagnostic accuracy of long non-coding RNAs (lncRNAs) in differentiating patients with oral squamous cell carcinoma (OSCC), and to explore their potential role in early detection.</p><p><strong>Methods: </strong>A literature search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library for studies published updated to 1 December 2024. Studies that explored the diagnostic accuracy of lncRNAs in OSCC were included. The risk of bias was assessed using the QUADAS-2. Diagnostic accuracy was calculated using indicators such as sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) by random effects modeling.</p><p><strong>Results: </strong>A total of eight studies were included in this meta-analysis, comprising 532 patients diagnosed with OSCC and 446 controls. The pooled sensitivity was 0.87 (95% CI: 0.61 to 0.97), and the specificity was 0.87 (95% CI: 0.76 to 0.93). The pooled PLR was 6.75 (95% CI: 3.12 to 14.58), and the NLR was 0.14 (95% CI: 0.04 to 0.57). The overall DOR was 46.87 (95% CI: 6.20 to 354.18). A higher diagnostic value was found for salivary and/or blood lncRNAs (DOR: 123.22; 95% CI: 9.79 to 1550.8) than for tissue lncRNAs (DOR: 6.24; 95% CI: 3.29 to 11.86).</p><p><strong>Conclusions: </strong>This study has demonstrated that lncRNAs were found to achieve high diagnostic accuracy for OSCC. lncRNAs expressed in body fluids have higher diagnostic value than those in tissues, and can be effectively utilized as potential biomarkers for OSCC detection.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102581"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long non-coding RNA as a potential diagnostic biomarker in oral squamous cell carcinoma: A systematic review and meta-analysis.\",\"authors\":\"Xingyu Liu, Jing Qiao, Han Qin\",\"doi\":\"10.1016/j.jormas.2025.102581\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study was conducted to assess the diagnostic accuracy of long non-coding RNAs (lncRNAs) in differentiating patients with oral squamous cell carcinoma (OSCC), and to explore their potential role in early detection.</p><p><strong>Methods: </strong>A literature search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library for studies published updated to 1 December 2024. Studies that explored the diagnostic accuracy of lncRNAs in OSCC were included. The risk of bias was assessed using the QUADAS-2. Diagnostic accuracy was calculated using indicators such as sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) by random effects modeling.</p><p><strong>Results: </strong>A total of eight studies were included in this meta-analysis, comprising 532 patients diagnosed with OSCC and 446 controls. The pooled sensitivity was 0.87 (95% CI: 0.61 to 0.97), and the specificity was 0.87 (95% CI: 0.76 to 0.93). The pooled PLR was 6.75 (95% CI: 3.12 to 14.58), and the NLR was 0.14 (95% CI: 0.04 to 0.57). The overall DOR was 46.87 (95% CI: 6.20 to 354.18). A higher diagnostic value was found for salivary and/or blood lncRNAs (DOR: 123.22; 95% CI: 9.79 to 1550.8) than for tissue lncRNAs (DOR: 6.24; 95% CI: 3.29 to 11.86).</p><p><strong>Conclusions: </strong>This study has demonstrated that lncRNAs were found to achieve high diagnostic accuracy for OSCC. lncRNAs expressed in body fluids have higher diagnostic value than those in tissues, and can be effectively utilized as potential biomarkers for OSCC detection.</p>\",\"PeriodicalId\":56038,\"journal\":{\"name\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"volume\":\" \",\"pages\":\"102581\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jormas.2025.102581\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology Oral and Maxillofacial Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jormas.2025.102581","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
Long non-coding RNA as a potential diagnostic biomarker in oral squamous cell carcinoma: A systematic review and meta-analysis.
Objective: This study was conducted to assess the diagnostic accuracy of long non-coding RNAs (lncRNAs) in differentiating patients with oral squamous cell carcinoma (OSCC), and to explore their potential role in early detection.
Methods: A literature search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library for studies published updated to 1 December 2024. Studies that explored the diagnostic accuracy of lncRNAs in OSCC were included. The risk of bias was assessed using the QUADAS-2. Diagnostic accuracy was calculated using indicators such as sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) by random effects modeling.
Results: A total of eight studies were included in this meta-analysis, comprising 532 patients diagnosed with OSCC and 446 controls. The pooled sensitivity was 0.87 (95% CI: 0.61 to 0.97), and the specificity was 0.87 (95% CI: 0.76 to 0.93). The pooled PLR was 6.75 (95% CI: 3.12 to 14.58), and the NLR was 0.14 (95% CI: 0.04 to 0.57). The overall DOR was 46.87 (95% CI: 6.20 to 354.18). A higher diagnostic value was found for salivary and/or blood lncRNAs (DOR: 123.22; 95% CI: 9.79 to 1550.8) than for tissue lncRNAs (DOR: 6.24; 95% CI: 3.29 to 11.86).
Conclusions: This study has demonstrated that lncRNAs were found to achieve high diagnostic accuracy for OSCC. lncRNAs expressed in body fluids have higher diagnostic value than those in tissues, and can be effectively utilized as potential biomarkers for OSCC detection.
期刊介绍：
J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics.
Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.
All manuscripts submitted to the journal are subjected to peer review by international experts, and must:
Be written in excellent English, clear and easy to understand, precise and concise;
Bring new, interesting, valid information - and improve clinical care or guide future research;
Be solely the work of the author(s) stated;
Not have been previously published elsewhere and not be under consideration by another journal;
Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed.
Under no circumstances does the journal guarantee publication before the editorial board makes its final decision.
The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.
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