Acta Paediatrica最新文献_第6页

Cephalhaematoma in Sweden, a Population-Based Register Study. 瑞典的脑血肿，一项基于人群的登记研究。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-21 DOI: 10.1111/apa.70110

Ulf Högberg, Vineta Fellman, Waney Squier, Knut Wester, Ingemar Thiblin

{"title":"Cephalhaematoma in Sweden, a Population-Based Register Study.","authors":"Ulf Högberg, Vineta Fellman, Waney Squier, Knut Wester, Ingemar Thiblin","doi":"10.1111/apa.70110","DOIUrl":"https://doi.org/10.1111/apa.70110","url":null,"abstract":"Aim: The primary aim was to investigate the incidence, birth characteristics, and timing of diagnosis of cephalhaematoma (CH). The secondary aim was to explore associations between CH and complications during the neonatal period and infancy.Methods: This is a nationwide population-based register study of infants (< 12 months) born in Sweden from 1997 to 2018. Information was retrieved from health registers of the Swedish National Board of Health and Welfare. Cases were infants with a diagnosis of birth-related CH.Results: The study comprises 2930 infants with CH. The incidence was 2.2 per 1000 births and increased during the study period. Most CH cases had a spontaneous vaginal delivery. Risk factors were ventouse, born preterm, large-for-gestational age, and occiput posterior presentation. Two-thirds were diagnosed before 7 days of life. A delayed diagnosis during later infancy became more common from the year 2000. Newborn infants had an increased risk of jaundice (10%). CH was associated with hypoxic encephalopathy (2.5%), convulsions (3.5%), skull fractures (0.6%), intraventricular haemorrhage (0.2%), subdural haemorrhage (0.5%) and stroke (0.2%).Conclusion: A substantial number of CH cases had a delayed diagnosis. A minority displayed symptoms of serious head trauma. CH was associated with intracranial haemorrhage.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary: Reassessing INSURE: Is Lung Recruitment Necessary? EBNEO评论：重新评估保险：肺补充是必要的吗？

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-21 DOI: 10.1111/apa.70100

David M Rub, Elizabeth E Foglia

引用次数: 0

Use of Antibiotics and Severe Bacterial Infections Within the First 6 Months of Life-A Population-Based Cohort Study From East Denmark. 生命前6个月内抗生素的使用和严重细菌感染——来自丹麦东部的一项基于人群的队列研究

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-21 DOI: 10.1111/apa.70103

Anna Bjerager Arnesen, Nini Møller, Louise Dyrberg Vibede, Kristian Vestergaard, Sara Krøis Holm, Cæcilie Trier, Hristo Stanchev, Gholamreza Dayani, Ulrikka Nygaard, Emma Malchau Carlsen, Bo Mølholm Hansen

{"title":"Use of Antibiotics and Severe Bacterial Infections Within the First 6 Months of Life-A Population-Based Cohort Study From East Denmark.","authors":"Anna Bjerager Arnesen, Nini Møller, Louise Dyrberg Vibede, Kristian Vestergaard, Sara Krøis Holm, Cæcilie Trier, Hristo Stanchev, Gholamreza Dayani, Ulrikka Nygaard, Emma Malchau Carlsen, Bo Mølholm Hansen","doi":"10.1111/apa.70103","DOIUrl":"https://doi.org/10.1111/apa.70103","url":null,"abstract":"Aim: To investigate antibiotic exposure and the incidence of severe bacterial infections during the first 6 months of life in preterm infants born between 28 and 37 weeks of gestation.Methods: Retrospective population-based study of preterm infants in East Denmark, 2019-2021. Participants were identified based on dispensed antibiotics through the joint electronic health system. Infectious episodes were defined as suspected (≤ 4 days of treatment), probable (≥ 5 days of treatment) or proven if blood culture positive.Results: During the first 6 months of life, 557 of 5128 (11%) preterm infants received 635 courses. Two-thirds of all antibiotic courses were administered within the first 72 h of life, with 12 proven infections, that is, 2.3 per 1000 live births. Beyond 72 h of age, nearly all bacterial infection episodes were hospital acquired, with 24 proven infections, that is, 4.7 per 1000 live births. Three infants had sepsis-related mortality, that is, 0.58 per 1000 live births.Conclusion: In preterm Danish infants aged 28-37 weeks of gestation, antibiotic treatment for suspected or probable infections was 15 times higher than for confirmed infections. Antibiotic exposure was high in this group of preterm infants, while confirmed infections were low.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodevelopmental Outcomes of Very Low Birth Weight Infants Following Extrauterine Placental Perfusion: A Follow-Up Study. 极低出生体重儿子宫外胎盘灌注后的神经发育结局：一项随访研究。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-18 DOI: 10.1111/apa.70101

Benjamin Kuehne, Martin Hellmich, Eva Heine, Angela Kribs, Katrin Mehler, André Oberthuer

{"title":"Neurodevelopmental Outcomes of Very Low Birth Weight Infants Following Extrauterine Placental Perfusion: A Follow-Up Study.","authors":"Benjamin Kuehne, Martin Hellmich, Eva Heine, Angela Kribs, Katrin Mehler, André Oberthuer","doi":"10.1111/apa.70101","DOIUrl":"https://doi.org/10.1111/apa.70101","url":null,"abstract":"Aim: Extrauterine placental perfusion (EPP) may be a feasible cord clamping strategy in very low birth weight (VLBW) infants to support neonatal transition. However, the impact of EPP on neurodevelopment remains unclear. The study aimed to compare the effects of EPP with time-based delayed cord clamping (DCC) on neurodevelopmental outcomes.Methods: This follow-up study of the randomised controlled EXPLAIN (Extrauterine Placental Transfusion in Resuscitation of Very Low Birth Weight Infants) trial (ClinicalTrials.gov Identifier: NCT03916159) was conducted at a tertiary perinatal centre from 2021 to 2023. Antenatally randomised VLBW infants received either EPP or DCC (> 30 s). Neurodevelopment was assessed at 24 months of corrected age using the Bayley Scales of Infant and Toddler Development, Third Edition. Data analysis was intention-to-treat.Results: Of 59 infants enrolled, 54 (92%) participated in the follow-up (27 EPP, 27 DCC). Median age at assessment was 24.3 months (range 23.5-25.0); 28 (52%) were male. Infant characteristics and short-term outcomes were similar between groups. No relevant differences were observed in median cognitive, motor or language scores or in rates of cerebral palsy, hearing, or visual impairment.Conclusion: The neurodevelopment of the VLBW infants who received EPP and DCC was comparable, suggesting that EPP may be a viable alternative.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary: Is Therapeutic Hypothermia Beneficial to Infants Born Between 33 and 35 Weeks Gestation? EBNEO评论：治疗性低温对妊娠33 - 35周出生的婴儿有益吗？

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-18 DOI: 10.1111/apa.70098

Harisa Spahic, Sandra P Zoubovsky, Robert M Dietz

引用次数: 0

Infant Reference Intervals-Steps Towards Improving the Supportive Data for Result Interpretation. 婴儿参考间隔-改善结果解释支持数据的步骤。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-18 DOI: 10.1111/apa.70095

Sara Marie Larsson

{"title":"Infant Reference Intervals-Steps Towards Improving the Supportive Data for Result Interpretation.","authors":"Sara Marie Larsson","doi":"10.1111/apa.70095","DOIUrl":"https://doi.org/10.1111/apa.70095","url":null,"abstract":"Aim: To fully take advantage of blood test results, comparative data are required. Today, the reference interval is a commonly used concept. This review aims to summarise the current state of reference intervals, focusing on infants.Methods: Literature on reference percentiles (birth to 12 months of age) published from January 1950 until November 2024 was reviewed. Search terms comprised paediatric, infant, or neonatal reference intervals and similar terminology. Furthermore, reference interval data in current clinical use were investigated by searching 7 Nordic laboratory websites for three routinely used biomarkers.Results: During infancy, the levels of several biomarkers change rapidly with development and growth. Conventionally used techniques for deriving reference intervals have limitations and require extensive blood samplings. New approaches basing reference limits on mathematically trimmed data from laboratory systems have emerged. Due to the risk of modelling pathological data, the results of these studies need verification. Recently published Nordic reference interval data, based on healthy infants and defined on specified time points, could present new opportunities.Conclusion: Infant reference interval methodology requires particular consideration. The currently observed heterogeneity in this area calls for further methodological investigations, improved concepts, harmonisation activities, and software development.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary on 'Physiological Versus Time Based Cord Clamping in Very Preterm Infants (ABC3): A Parallel-Group, Multicentre, Randomised, Controlled Superiority Trial'. EBNEO关于“非常早产儿（ABC3）的生理性与时间型脐带夹紧：一项平行组、多中心、随机、对照的优势试验”的评论。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-17 DOI: 10.1111/apa.70099

Anup C Katheria, Henry C Lee

引用次数: 0

Immune Thrombocytopenia in Finnish Children and Adolescents: A Population-Based Cohort Study. 芬兰儿童和青少年的免疫性血小板减少症：一项基于人群的队列研究

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-16 DOI: 10.1111/apa.70090

Lauri-Matti Kulmala, Henri Aarnivala, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Riitta Niinimäki

{"title":"Immune Thrombocytopenia in Finnish Children and Adolescents: A Population-Based Cohort Study.","authors":"Lauri-Matti Kulmala, Henri Aarnivala, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Riitta Niinimäki","doi":"10.1111/apa.70090","DOIUrl":"https://doi.org/10.1111/apa.70090","url":null,"abstract":"Aim: Immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia in children. This study aimed to describe the diagnostics, patient characteristics, and treatment strategies regarding children with ITP, as well as identify risk factors for chronic disease.Methods: This study included 403 Finnish children aged under 16 years at diagnosis, who were first diagnosed with ITP between 2006 and 2020.Results: Of the 367/403 patients with complete follow-up data, 242 (65.9%) recovered within three months. Chronic ITP developed in 25.9% of the children. Severe bleeding events occurred in 3.7% of them, with no intracranial bleeding events or deaths reported. Pharmacological treatment was administered to 40.2% of the patients. An elevated risk of chronic ITP was found in the children presenting with an insidious disease onset, female gender, higher age, higher platelet counts, and an absence of recent viral infections. As many as 83.3% of the patients with an insidious disease onset and no recent infections developed chronic ITP.Conclusion: Most of the children with ITP experienced short and uncomplicated disease courses. Chronic illness was more likely when the disease onset was insidious, the platelet count was not extremely low, and there was no recent history of an infection.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: "A Systematic Review: Sports and High-Grade Kidney Injuries in Children With Solitary Kidneys". 评论：“一项系统综述：孤立肾儿童的运动和高度肾损伤”。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-15 DOI: 10.1111/apa.70097

Shubham Kumar, Rachana Mehta, Ranjana Sah

引用次数: 0

Development and Validation of POCOKIDS-Q-A Questionnaire to Assess Post COVID-19 Symptoms in Children. POCOKIDS-Q-A问卷用于评估儿童COVID-19后症状的编制与验证

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-04-13 DOI: 10.1111/apa.70094

C Angelhoff, M Jedenfalk, E Fernlund, E Svensson, K Duchen, P Ertzgaard

{"title":"Development and Validation of POCOKIDS-Q-A Questionnaire to Assess Post COVID-19 Symptoms in Children.","authors":"C Angelhoff, M Jedenfalk, E Fernlund, E Svensson, K Duchen, P Ertzgaard","doi":"10.1111/apa.70094","DOIUrl":"https://doi.org/10.1111/apa.70094","url":null,"abstract":"Aim: To identify the symptom burden in children and adolescents with post COVID-19, a validated and reliable instrument is needed, particularly to assess symptoms and their impact on the child. The aim of this study was to describe the development, validation, and reliability of the Post COVID-19 in Kids Questionnaire (POCOKIDS-Q), which was designed to assess post COVID-19 symptoms in children and adolescents.Methods: The POCOKIDS-Q was developed based on literature, clinical experience, and questionnaires for adults with post COVID-19. The linguistic validation involved 9- to 17-year-old children. Children and adolescents with the onset of post COVID-19 symptoms were asked to complete the final version through a web link. Exploratory and confirmatory factor analyses were performed to identify a factor structure that explains the covariances between the variables.Results: The link to the POCOKIDS-Q was opened 324 times and fully completed by 213 (66%) children and young adults (median age 14 years) with post COVID-19 symptoms. Confirmatory factor analyses revealed four significant and correlated factors: brain fatigue, cognitive impact, physical impact, and emotional impact. The explanatory power of the factor model is high.Conclusion: The POCOKIDS-Q is applicable for assessing post COVID-19 symptoms in children and young adults.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0